PROTEIN CITRULLINATION%HUMANCYC%PWY-4921 protein citrullination PADI6 PADI3 PADI2 PADI4 PADI1 METHYLGLYOXAL DEGRADATION III%HUMANCYC%PWY-5453 methylglyoxal degradation III AKR1B10 AKR1B1 CYP2E1 STEARATE BIOSYNTHESIS I (ANIMALS)%HUMANCYC%PWY-5972 stearate biosynthesis I (animals) ELOVL1 ACOT7 ACSL1 ACSL5 ELOVL6 ACSL4 ACSL3 ACOT2 ACOT1 ACSBG1 ACSBG2 SLC27A2 ACOT4 TRYPTOPHAN DEGRADATION X (MAMMALIAN, VIA TRYPTAMINE)%HUMANCYC%PWY-6307 tryptophan degradation X (mammalian, via tryptamine) ALDH3A2 DDC MAOB MAOA AKR1A1 CERAMIDE BIOSYNTHESIS%HUMANCYC%PWY3DJ-12 ceramide biosynthesis SPTLC1 SPTLC2 SPTLC3 KDSR DEGS2 L-SERINE DEGRADATION%HUMANCYC%SERDEG-PWY L-serine degradation SDS SDSL SUPERPATHWAY OF INOSITOL PHOSPHATE COMPOUNDS%HUMANCYC%PWY-6371 superpathway of inositol phosphate compounds PI4K2B MTMR14 INPPL1 PTEN PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP4P2 PIP4P1 PLCZ1 PPIP5K1 PPIP5K2 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C SACM1L ITPK1 IPMK OCRL ITPKB ITPKC MINPP1 PLCB3 PLCB4 PIK3CA ITPKA PIK3C3 PLCB1 PLCB2 PI4K2A IPPK MTMR3 PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 INPP5B INPP5A INPP5D PLCG2 INPP5J PIP5K1A INPP5K PIP5K1B PIP5K1C PLCG1 CDIPT IP6K1 IP6K3 IP6K2 SYNJ2 FIG4 PIKFYVE SYNJ1 PI4KA PLCH1 PI4KB PLCH2 PLCD3 PLCD4 PLCD1 PUTRESCINE DEGRADATION III%HUMANCYC%PWY-0 putrescine degradation III ALDH3A2 ALDH3B2 ALDH3A1 ALDH1B1 MAOB ALDH2 MAOA ALDH3B1 SAT2 SAT1 TETRAHYDROFOLATE SALVAGE FROM 5,10-METHENYLTETRAHYDROFOLATE%HUMANCYC%PWY-6613 tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate MTHFD1 MTHFD2 MTHFD2L GART ANDROGEN BIOSYNTHESIS%HUMANCYC%PWY66-378 androgen biosynthesis AKR1C3 CYP17A1 HSD3B2 SRD5A2 SRD5A1 HSD3B1 HSD17B3 PHENYLALANINE DEGRADATION I (AEROBIC)%HUMANCYC%PHENYLALANINE-DEG1-PWY phenylalanine degradation I (aerobic) QDPR PAH PCBD1 PCBD2 TRYPTOPHAN DEGRADATION III (EUKARYOTIC)%HUMANCYC%TRYPTOPHAN-DEGRADATION-1 tryptophan degradation III (eukaryotic) ACAT1 HADHB GCDH TDO2 KYNU HAAO AFMID KMO ACAA1 ACAT2 ACMSD SULFITE OXIDATION IV%HUMANCYC%PWY-5326 sulfite oxidation IV SUOX MEVALONATE PATHWAY I%HUMANCYC%PWY-922 mevalonate pathway I ACAT1 IDI1 MVK HMGCS1 IDI2 HADHB PMVK MVD HMGCR HMGCS2 ACAA1 ACAT2 XANTHINE AND XANTHOSINE SALVAGE%HUMANCYC%SALVPURINE2-PWY xanthine and xanthosine salvage PNP SERINE BIOSYNTHESIS%HUMANCYC%SERSYN-PWY serine biosynthesis PSAT1 PHGDH PSPH MYO< I>-INOSITOL BIOSYNTHESIS%HUMANCYC%PWY-2301 myo< i>-inositol biosynthesis IMPA2 BPNT2 ISYNA1 IMPA1 ADENINE AND ADENOSINE SALVAGE I%HUMANCYC%P121-PWY adenine and adenosine salvage I APRT D-MYO< I>-INOSITOL-5-PHOSPHATE METABOLISM%HUMANCYC%PWY-6367 D-myo< i>-inositol-5-phosphate metabolism PLCG1 PLCB3 PLCB4 PLCH1 PLCH2 PLCB1 MTMR14 PLCD3 PLCB2 PLCD4 PLCD1 MTMR3 PIP4P2 PIP4P1 PLCZ1 PLCG2 PLCE1 PIP4K2A PIP4K2C PURINE NUCLEOTIDES DEGRADATION II (AEROBIC)%HUMANCYC%PWY-6353 purine nucleotides degradation II (aerobic) GDA NT5C2 ADAT3 NT5C3A NT5C3B NT5E IMPDH1 IMPDH2 NT5C1A NT5C1B XDH ADA PNP HISTAMINE BIOSYNTHESIS%HUMANCYC%PWY-6173 histamine biosynthesis HDC ASPARTATE BIOSYNTHESIS%HUMANCYC%ASPARTATESYN-PWY aspartate biosynthesis GOT1L1 GOT1 GOT2 UDP-D-XYLOSE AND UDP-D-GLUCURONATE BIOSYNTHESIS%HUMANCYC%PWY-4821 UDP-D-xylose and UDP-D-glucuronate biosynthesis UGDH UXS1 GDP-L-FUCOSE BIOSYNTHESIS II (FROM L-FUCOSE)%HUMANCYC%PWY-6 GDP-L-fucose biosynthesis II (from L-fucose) FCSK FPGT D-MYO< I>-INOSITOL (3,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6365 D-myo< i>-inositol (3,4,5,6)-tetrakisphosphate biosynthesis ITPK1 IPMK PHOSPHATIDYLGLYCEROL BIOSYNTHESIS II (NON-PLASTIDIC)%HUMANCYC%PWY4FS-8 phosphatidylglycerol biosynthesis II (non-plastidic) AGPAT3 AGPAT4 PGS1 GPAM LPCAT4 GPAT4 GPD2 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT1 AGPAT2 LCLAT1 NADH REPAIR%HUMANCYC%PWY-6938 NADH repair NAXE NAXD GAPDH INOSINE-5'-PHOSPHATE BIOSYNTHESIS II%HUMANCYC%PWY-6124 inosine-5'-phosphate biosynthesis II PAICS ADSL ATIC PHENYLETHYLAMINE DEGRADATION I%HUMANCYC%2PHENDEG-PWY phenylethylamine degradation I ALDH3A2 AOC3 AOC2 ALDH2 DOLICHOL AND DOLICHYL PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6129 dolichol and dolichyl phosphate biosynthesis SRD5A3 DOLK DHDDS (S)-RETICULINE BIOSYNTHESIS II%HUMANCYC%PWY-6133 (S)-reticuline biosynthesis II TYR FATTY ACID &ALPHA;-OXIDATION II%HUMANCYC%PWY66-387 fatty acid α-oxidation II ACSL1 ACSL5 PHYH ACSL6 ACSL4 HACL1 ACSL3 ACSBG1 ACSBG2 SLC27A2 METHYLGLYOXAL DEGRADATION I%HUMANCYC%PWY-5386 methylglyoxal degradation I GLO1 LDHD HAGH GUANOSINE NUCLEOTIDES DEGRADATION III%HUMANCYC%PWY-6608 guanosine nucleotides degradation III GDA NT5C2 PNP XDH MITOCHONDRIAL L-CARNITINE SHUTTLE PATHWAY%HUMANCYC%PWY-6111 mitochondrial L-carnitine shuttle pathway CPT1A CPT2 CPT1C PYRIDOXAL 5'-PHOSPHATE SALVAGE PATHWAY%HUMANCYC%PLPSAL-PWY pyridoxal 5'-phosphate salvage pathway PDXK PNPO L-DOPA DEGRADATION%HUMANCYC%PWY-6334 L-dopa degradation COMT CMP-N< I>-ACETYLNEURAMINATE BIOSYNTHESIS I (EUKARYOTES)%HUMANCYC%PWY-6138 CMP-N< i>-acetylneuraminate biosynthesis I (eukaryotes) NANP CMAS NANS GNE URIDINE-5'-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5686 uridine-5'-phosphate biosynthesis CAD UMPS ETHANOL DEGRADATION IV%HUMANCYC%PWY66-162 ethanol degradation IV ALDH3A2 ALDH2 ACSS3 ACSS2 TYRP1 CAT ACSS1 GLUTAMINE DEGRADATION I%HUMANCYC%GLUTAMINDEG-PWY glutamine degradation I GLS GLS2 ASNS METHYLMALONYL PATHWAY%HUMANCYC%PROPIONMET-PWY methylmalonyl pathway MCEE PCCA PCCB MMUT SELENOCYSTEINE BIOSYNTHESIS II (ARCHAEA AND EUKARYOTES)%HUMANCYC%PWY-6281 selenocysteine biosynthesis II (archaea and eukaryotes) SEPSECS SARS1 SARS2 SEPHS1 SEPHS2 PSTK GLYCEROL DEGRADATION I%HUMANCYC%PWY-4261 glycerol degradation I GK5 GK3P GK GK2 HEME BIOSYNTHESIS FROM UROPORPHYRINOGEN-III I%HUMANCYC%HEME-BIOSYNTHESIS-II heme biosynthesis from uroporphyrinogen-III I UROD CPOX PPOX FECH DERMATAN SULFATE BIOSYNTHESIS (LATE STAGES)%HUMANCYC%PWY-6568 dermatan sulfate biosynthesis (late stages) DSE UST CHST15 CHST14 ALANINE BIOSYNTHESIS III%HUMANCYC%PWY0-1021 alanine biosynthesis III NFS1 KETOGENESIS%HUMANCYC%REACT_1464.NULL ketogenesis ACAT1 HADHB HMGCL BDH1 HMGCS2 ACAA1 OXIDIZED GTP AND DGTP DETOXIFICATION%HUMANCYC%PWY-6502 oxidized GTP and dGTP detoxification NUDT1 FOLATE POLYGLUTAMYLATION%HUMANCYC%PWY-2161 folate polyglutamylation MTHFD1 MTHFD1L SHMT2 SHMT1 FPGS ZYMOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6074 zymosterol biosynthesis CYP51A1 MSMO1 HSD17B7 LBR TM7SF2 NSDHL N< I>-ACETYLGLUCOSAMINE DEGRADATION II%HUMANCYC%PWY-6517 N< i>-acetylglucosamine degradation II NAGK GNPDA1 GNPDA2 AMDHD2 LANOSTEROL BIOSYNTHESIS%HUMANCYC%PWY-6132 lanosterol biosynthesis LSS GLYCINE DEGRADATION (CREATINE BIOSYNTHESIS)%HUMANCYC%GLYCGREAT-PWY glycine degradation (creatine biosynthesis) GAMT GATM PHOSPHATIDYLCHOLINE BIOSYNTHESIS I%HUMANCYC%PWY3O-450 phosphatidylcholine biosynthesis I CHPT1 CEPT1 PCYT1B PCYT1A CHKB CHKA 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE DEGRADATION TO GLUTARYL-COA%HUMANCYC%PWY-5652 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA ACMSD D-MANNOSE DEGRADATION%HUMANCYC%MANNCAT-PWY D-mannose degradation MPI INOSITOL PYROPHOSPHATES BIOSYNTHESIS%HUMANCYC%PWY-6369 inositol pyrophosphates biosynthesis IPMK IP6K1 IP6K3 IP6K2 PPIP5K1 PPIP5K2 IPPK GLUTARYL-COA DEGRADATION%HUMANCYC%PWY-5177 glutaryl-CoA degradation ACAT1 HADHB GCDH ACAA1 ACAT2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS I%HUMANCYC%PWY-5512 UDP-N< i>-acetyl-D-galactosamine biosynthesis I GALE TRNA CHARGING%HUMANCYC%TRNA-CHARGING-PWY tRNA charging LARS1 TARS2 TARS3 CARS1 FARSA CARS2 TARS1 FARSB AARS1 AARS2 KARS1 PARS2 YARS1 YARS2 FARS2 QARS1 NARS1 NARS2 IARS2 IARS1 VARS2 EARS2 VARS1 RARS2 HARS1 RARS1 MARS2 SARS1 MARS1 SARS2 DARS2 HARS2 WARS1 DARS1 WARS2 GARS1 LARS2 EPRS1 DIPHTHAMIDE BIOSYNTHESIS%HUMANCYC%PWY-6482 diphthamide biosynthesis DPH5 CALCIUM TRANSPORT I%HUMANCYC%PWY-6166 calcium transport I ATP2A3 ATP2A2 ATP2A1 ATP2C2 ATP2C1 SUCROSE DEGRADATION V (MAMMALIAN)%HUMANCYC%PWY66-373 sucrose degradation V (mammalian) GALM ALDOB ALDOA KHK TPI1 SI 4-HYDROXYBENZOATE BIOSYNTHESIS%HUMANCYC%PWY-5754-1 4-hydroxybenzoate biosynthesis TAT S< I>-METHYL-5'-THIOADENOSINE DEGRADATION II%HUMANCYC%PWY-6756 S< i>-methyl-5'-thioadenosine degradation II MTAP ASPARAGINE BIOSYNTHESIS I%HUMANCYC%ASPARAGINE-BIOSYNTHESIS asparagine biosynthesis I ASNS 2-OXOBUTANOATE DEGRADATION I%HUMANCYC%PWY-5130 2-oxobutanoate degradation I MCEE PCCA PCCB MMUT BCKDHA DBT BCKDHB DLD SPERMIDINE BIOSYNTHESIS I%HUMANCYC%BSUBPOLYAMSYN-PWY spermidine biosynthesis I AMD1 SRM DTMP DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY66-385 dTMP de novo< i> biosynthesis DHFR SHMT2 SHMT1 TYMS ACETYL-COA BIOSYNTHESIS III (FROM CITRATE)%HUMANCYC%PWY-5172 acetyl-CoA biosynthesis III (from citrate) ACLY SUPERPATHWAY OF D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE METABOLISM%HUMANCYC%PWY-6358 superpathway of D-myo< i>-inositol (1,4,5)-trisphosphate metabolism INPP5F IMPA2 BPNT2 IPMK OCRL ITPKB SYNJ2 ITPKC MINPP1 SYNJ1 ITPKA INPPL1 PTEN INPP5B INPP5A INPP5D INPP5J INPP5K INPP1 IMPA1 TRIACYLGLYCEROL DEGRADATION%HUMANCYC%LIPAS-PWY triacylglycerol degradation PNLIPRP2 ABHD6 CEL ABHD12 LIPF LIPE LIPC LIPG PNPLA3 PNPLA4 MGLL PNLIPRP3 PNLIP PNPLA2 GLUCOSE AND GLUCOSE-1-PHOSPHATE DEGRADATION%HUMANCYC%GLUCOSE1PMETAB-PWY glucose and glucose-1-phosphate degradation PGM2 PGM5 PGM1 GCK HKDC1 CHOLESTEROL BIOSYNTHESIS I%HUMANCYC%PWY66-341 cholesterol biosynthesis I NSDHL CYP51A1 MSMO1 HSD17B7 LBR DHCR24 TM7SF2 SQLE EBP SC5D DHCR7 LSS FDFT1 HISTIDINE DEGRADATION III%HUMANCYC%PWY-5030 histidine degradation III MTHFD1 MTHFD2 MTHFD2L HAL UROC1 AMDHD1 FTCD SPHINGOMYELIN METABOLISM%HUMANCYC%PWY3DJ-11281 sphingomyelin metabolism SMPD4 SAMD8 SGMS1 SMPD1 SGMS2 ENPP7 SMPD3 SMPD2 TETRAHYDROBIOPTERIN BIOSYNTHESIS I%HUMANCYC%PWY-5663 tetrahydrobiopterin biosynthesis I GCH1 SPR PTS FORMALDEHYDE OXIDATION II (GLUTATHIONE-DEPENDENT)%HUMANCYC%PWY-1801 formaldehyde oxidation II (glutathione-dependent) ESD ADH5 RAPOPORT-LUEBERING GLYCOLYTIC SHUNT%HUMANCYC%PWY-6405 Rapoport-Luebering glycolytic shunt MINPP1 PGAM1 PGAM2 BPGM D-GLUCURONATE DEGRADATION I%HUMANCYC%PWY-5525 D-glucuronate degradation I DCXR CRYL1 NORADRENALINE AND ADRENALINE DEGRADATION%HUMANCYC%PWY-6342 noradrenaline and adrenaline degradation PNMT ALDH3A2 ADH4 LRTOMT MAOB COMT ALDH2 MAOA ADH1B ADH6 ARGININE DEGRADATION I (ARGINASE PATHWAY)%HUMANCYC%ARGASEDEG-PWY arginine degradation I (arginase pathway) ALDH4A1 ARG2 OAT ARG1 PHOSPHOLIPASES%HUMANCYC%LIPASYN-PWY phospholipases PLCB3 PLCB4 PLCB1 PLCB2 PLA2G1B PLA2G3 PLCG2 PLD4 PLD6 PLA2G5 PLD1 PLA2G6 PLD3 PLCG1 PLB1 PLD2 OC90 PLA2G2F PLA2G12A PLA2G2D PLA2G4F PLA2G2E PLA2G4D PNPLA8 PLCH1 PLA2G4E PLA2G4B PLCH2 PLA2G2A PLCD3 PLA2G4C PLCD4 PLA2G4A PLCD1 PLAAT3 PLA2G10 PLCZ1 PLCE1 D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE DEGRADATION%HUMANCYC%PWY-6363 D-myo< i>-inositol (1,4,5)-trisphosphate degradation INPP5F IMPA2 BPNT2 OCRL SYNJ2 SYNJ1 INPPL1 INPP5B INPP5A INPP5J INPP5K INPP1 IMPA1 ADENINE AND ADENOSINE SALVAGE VI%HUMANCYC%PWY-6619 adenine and adenosine salvage VI ADK KETOLYSIS%HUMANCYC%REACT_59.NULL ketolysis ACAT1 BDH2 OXCT1 HADHB BDH1 ACAA1 NAD PHOSPHORYLATION AND DEPHOSPHORYLATION%HUMANCYC%NADPHOS-DEPHOS-PWY NAD phosphorylation and dephosphorylation NNT ACP6 PXYLP1 NADK NAD BIOSYNTHESIS FROM 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde NMNAT1 QPRT NMNAT3 NMNAT2 NADSYN1 L-CYSTEINE DEGRADATION II%HUMANCYC%LCYSDEG-PWY L-cysteine degradation II CTH DOPAMINE DEGRADATION%HUMANCYC%PWY6666-2 dopamine degradation ALDH3A2 SULT1A4 SULT1A2 MAOB COMT MAOA SULT1A1 UREA CYCLE%HUMANCYC%PWY-4984 urea cycle CPS1 ASL ASS1 OTC ARG2 ARG1 GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5120 geranylgeranyldiphosphate biosynthesis GGPS1 ANANDAMIDE DEGRADATION%HUMANCYC%PWY6666-1 anandamide degradation FAAH FAAH2 3-PHOSPHOINOSITIDE DEGRADATION%HUMANCYC%PWY-6368 3-phosphoinositide degradation SACM1L INPP5F OCRL SYNJ2 SYNJ1 TPTE2 INPP4A INPP4B PTPMT1 MTMR14 INPP5E INPPL1 PTEN MTMR3 PIP4P2 INPP5B PIP4P1 INPP5D INPP5J INPP5K PENTOSE PHOSPHATE PATHWAY%HUMANCYC%PENTOSE-P-PWY pentose phosphate pathway TKTL1 G6PD H6PD RPE TALDO1 PGLS TKT PGD TKTL2 RPIA ALL-TRANS< I>-DECAPRENYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5806 all-trans< i>-decaprenyl diphosphate biosynthesis PDSS2 PDSS1 OXIDATIVE ETHANOL DEGRADATION III%HUMANCYC%PWY66-161 oxidative ethanol degradation III ALDH3A2 CYP2E1 ALDH2 ACSS3 CYP2G1P ACSS2 ACSS1 HEME BIOSYNTHESIS II%HUMANCYC%PWY-5920 heme biosynthesis II UROD CPOX PPOX ALAD ALAS2 ALAS1 UROS FECH HMBS GDP-GLUCOSE BIOSYNTHESIS%HUMANCYC%PWY-5661 GDP-glucose biosynthesis PGM2 PGM5 PGM1 GCK HKDC1 L-CYSTEINE DEGRADATION I%HUMANCYC%CYSTEINE-DEG-PWY L-cysteine degradation I CDO1 GOT1 TRYPTOPHAN DEGRADATION TO 2-AMINO-3-CARBOXYMUCONATE SEMIALDEHYDE%HUMANCYC%PWY-5651 tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde TDO2 KYNU HAAO AFMID KMO EUMELANIN BIOSYNTHESIS%HUMANCYC%PWY-6498 eumelanin biosynthesis DCT TRPC1 TYR TYRP1 SPERMINE AND SPERMIDINE DEGRADATION I%HUMANCYC%PWY-6117 spermine and spermidine degradation I AOC3 SMOX PAOX SAT2 SAT1 URATE BIOSYNTHESIS INOSINE 5'-PHOSPHATE DEGRADATION%HUMANCYC%PWY-5695 urate biosynthesis inosine 5'-phosphate degradation NT5C2 NT5C3B NT5E IMPDH1 PNP IMPDH2 NT5C1B XDH 5-AMINOIMIDAZOLE RIBONUCLEOTIDE BIOSYNTHESIS I%HUMANCYC%PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I PPAT PFAS GART SEROTONIN AND MELATONIN BIOSYNTHESIS%HUMANCYC%PWY-6030 serotonin and melatonin biosynthesis DDC TPH2 TPH1 AANAT ASMT ACYL-COA HYDROLYSIS%HUMANCYC%PWY-5148 acyl-CoA hydrolysis ACOT7 ACOT9 ACOT8 HISTAMINE DEGRADATION%HUMANCYC%PWY-6181 histamine degradation AOC2 AOC1 HNMT ALANINE BIOSYNTHESIS II%HUMANCYC%ALANINE-SYN2-PWY alanine biosynthesis II GPT GPT2 ALANINE DEGRADATION III%HUMANCYC%ALANINE-DEG3-PWY alanine degradation III GPT GPT2 MAP KINASE CASCADE%HUMANCYC%REACT_634.NULL MAP kinase cascade YWHAB CHOLINE BIOSYNTHESIS III%HUMANCYC%PWY-3561 choline biosynthesis III CHPT1 PLD3 CEPT1 PLD2 PLD4 PCYT1B PLD6 PCYT1A PLD1 BMP SIGNALLING PATHWAY%HUMANCYC%REACT_12034.NULL BMP Signalling Pathway SKI BMP2 SMAD4 ZFYVE16 UBE2D3 UBE2D1 TETRAPYRROLE BIOSYNTHESIS II%HUMANCYC%PWY-5189 tetrapyrrole biosynthesis II ALAD ALAS2 ALAS1 UROS HMBS LEUKOTRIENE BIOSYNTHESIS%HUMANCYC%15354 leukotriene biosynthesis ALOX5 DPEP2 DPEP1 GGT3P LTA4H LTC4S GGT2 FLAVIN BIOSYNTHESIS IV (MAMMALIAN)%HUMANCYC%11070 flavin biosynthesis IV (mammalian) RFK FLAD1 GLYCOGEN DEGRADATION II%HUMANCYC%PWY-5941 glycogen degradation II PGM2 PYGB PGM5 AGL PGM1 PYGM PYGL 4-HYDROXYPROLINE DEGRADATION I%HUMANCYC%HYDROXYPRODEG-PWY 4-hydroxyproline degradation I ALDH4A1 TRANS, TRANS< I>-FARNESYL DIPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-5123 trans, trans< i>-farnesyl diphosphate biosynthesis IDI1 FDPS IDI2 GGPS1 L-GLUTAMINE BIOSYNTHESIS II (TRNA-DEPENDENT)%HUMANCYC%PWY-5921 L-glutamine biosynthesis II (tRNA-dependent) GATB QRSL1 OLEATE BIOSYNTHESIS II (ANIMALS)%HUMANCYC%PWY-5996 oleate biosynthesis II (animals) FADS2 FADS6 SCD ACOT2 SCD5 ACOT1 FADS1 ACOT4 PYRUVATE FERMENTATION TO LACTATE%HUMANCYC%PWY-5481 pyruvate fermentation to lactate LDHAL6A LDHAL6B LDHC LDHB LDHA D-MYO< I>-INOSITOL (1,4,5)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6351 D-myo< i>-inositol (1,4,5)-trisphosphate biosynthesis PLCB3 PLCB4 PLCB1 PLCB2 PI4K2A PLCG2 PIP5K1A PIP5K1B PIP5K1C PLCG1 CDIPT PI4KA PLCH1 PI4KB PI4K2B PLCH2 PLCD3 PLCD4 PLCD1 PLCZ1 PIP5KL1 PLCE1 PIP4K2A PIP4K2B PIP4K2C GLUTATHIONE-MEDIATED DETOXIFICATION I%HUMANCYC%PWY-4061 glutathione-mediated detoxification I GSTZ1 GSTA5 GSTA4 GSTA3 ANPEP GSTA2 GSTA1 GGT1 GSTT2B GSTM5 GSTM4 GSTK1 GSTM3 GGT7 GSTM2 GGT6 GSTM1 GSTO2 MGST3 GSTP1 MGST1 GGH MGST2 GSTT1 LYSINE DEGRADATION II%HUMANCYC%LYSINE-DEG1-PWY lysine degradation II SCCPDH ALDH7A1 AASS PROLINE BIOSYNTHESIS I%HUMANCYC%PROSYN-PWY proline biosynthesis I ALDH18A1 PYCR1 PYCR2 PYCR3 FATTY ACID &BETA;-OXIDATION I%HUMANCYC%FAO-PWY fatty acid β-oxidation I HADHB ACAA1 ACAA2 ECHS1 ECI1 ECI2 ACSL1 HSD17B10 ACSL5 HADHA EHHADH ACSL6 ACSL4 HADH ACSL3 ACSBG1 ACSBG2 SLC27A2 UDP-N< I>-ACETYL-D-GLUCOSAMINE BIOSYNTHESIS II%HUMANCYC%UDPNACETYLGALSYN-PWY UDP-N< i>-acetyl-D-glucosamine biosynthesis II GFPT2 GFPT1 PGM3 GNPNAT1 UAP1 CDP-DIACYLGLYCEROL BIOSYNTHESIS I%HUMANCYC%PWY-5667 CDP-diacylglycerol biosynthesis I AGPAT3 AGPAT4 GPAM LPCAT4 GPAT4 GPD2 LPCAT3 GPAT3 GPAT2 CDS2 AGPAT5 CDS1 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT1 AGPAT2 LCLAT1 PUTRESCINE BIOSYNTHESIS III%HUMANCYC%PWY-46 putrescine biosynthesis III ODC1 AZIN2 GDP-L-FUCOSE BIOSYNTHESIS I (FROM GDP-D-MANNOSE)%HUMANCYC%PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) GMDS GFUS COLANIC ACID BUILDING BLOCKS BIOSYNTHESIS%HUMANCYC%COLANSYN-PWY colanic acid building blocks biosynthesis GMDS GFUS GPI MPI GALT GALE PMM1 PMM2 GMPPB UGP2 GMPPA GALK1 UGDH SALVAGE PATHWAYS OF PYRIMIDINE DEOXYRIBONUCLEOTIDES%HUMANCYC%PWY0-181 salvage pathways of pyrimidine deoxyribonucleotides CDA TK2 TK1 AICDA TYMP D-MYO< I>-INOSITOL (1,4,5,6)-TETRAKISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6366 D-myo< i>-inositol (1,4,5,6)-tetrakisphosphate biosynthesis ITPK1 IPMK MINPP1 1,25-DIHYDROXYVITAMIN D3< SUB> BIOSYNTHESIS%HUMANCYC%PWY-6076 1,25-dihydroxyvitamin D3< sub> biosynthesis POR CYP2R1 CYP27B1 GALACTOSE DEGRADATION I (LELOIR PATHWAY)%HUMANCYC%PWY-6317 galactose degradation I (Leloir pathway) GALM GALE GALT GALK1 THIOSULFATE DISPROPORTIONATION III (RHODANESE)%HUMANCYC%PWY-5350 thiosulfate disproportionation III (rhodanese) TST METHYLTHIOPROPIONATE BIOSYNTHESIS%HUMANCYC%PWY-5389 methylthiopropionate biosynthesis ADI1 SUPERPATHWAY OF SERINE AND GLYCINE BIOSYNTHESIS I%HUMANCYC%SER-GLYSYN-PWY superpathway of serine and glycine biosynthesis I PSAT1 SHMT2 PHGDH SHMT1 PSPH NAD SALVAGE PATHWAY III%HUMANCYC%PWY3O-4106 NAD salvage pathway III NMRK2 NMRK1 NMNAT1 NMNAT3 NMNAT2 CHONDROITIN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6573 chondroitin sulfate degradation (metazoa) GALNS HYAL1 HEXA HYAL4 ARSB SPAM1 L-DOPACHROME BIOSYNTHESIS%HUMANCYC%PWY-6481 L-dopachrome biosynthesis TYR GLUCONEOGENESIS I%HUMANCYC%GLUCONEO-PWY gluconeogenesis I ENO3 VCAN GPI GAPDHS PGK1 ME1 ME3 ME2 PGK2 PCK1 FBP1 FBP2 PGAM1 PGAM2 BPGM GAPDH ALDOB ALDOA MDH1 MDH2 ENO1 ENO2 GLUTAMATE DEPENDENT ACID RESISTANCE%HUMANCYC%PWY0-1305 glutamate dependent acid resistance GAD1 GAD2 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS V (FROM INS(1,3,4)P3)%HUMANCYC%PWY-6554 1D-myo< i>-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) ITPK1 IPMK IPPK GLYCINE BIOSYNTHESIS III%HUMANCYC%GLYSYN-ALA-PWY glycine biosynthesis III AGXT2 AGXT TYROSINE BIOSYNTHESIS IV%HUMANCYC%PWY-6134 tyrosine biosynthesis IV PAH ADENOSINE NUCLEOTIDES DEGRADATION II%HUMANCYC%SALVADEHYPOX-PWY adenosine nucleotides degradation II NT5C2 ADAT3 NT5C3A NT5E PNP NT5C1A NT5C1B XDH ADA GLUTAMATE DEGRADATION II%HUMANCYC%GLUTDEG-PWY glutamate degradation II GOT1L1 GOT1 GOT2 CARDIOLIPIN BIOSYNTHESIS II%HUMANCYC%PWY-5269 cardiolipin biosynthesis II PGS1 CRLS1 THIAMIN SALVAGE III%HUMANCYC%PWY-6898 thiamin salvage III TPK1 DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE BIOSYNTHESIS%HUMANCYC%MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS dolichyl-diphosphooligosaccharide biosynthesis DPAGT1 DPM1 ALG8 DPM3 ALG6 ALG5 ALG3 ALG13 ALG1 FATTY ACID BIOSYNTHESIS INITIATION II%HUMANCYC%PWY-5966 fatty acid biosynthesis initiation II SLC35G3 OXSM FASN GLUTAMATE BIOSYNTHESIS II%HUMANCYC%GLUTAMATE-SYN2-PWY glutamate biosynthesis II GLUD1 GLUD2 TAURINE BIOSYNTHESIS%HUMANCYC%PWY-5331 taurine biosynthesis CDO1 CSAD FATTY ACID ACTIVATION%HUMANCYC%PWY-5143 fatty acid activation ACSL1 ACSL5 ACSL6 ACSL4 ACSL3 ACSBG1 ACSBG2 SLC27A2 S< I>-METHYL-5-THIO-&ALPHA;-D-RIBOSE 1-PHOSPHATE DEGRADATION%HUMANCYC%PWY-6755 S< i>-methyl-5-thio-α-D-ribose 1-phosphate degradation APIP MRI1 ENOPH1 ADI1 PENTOSE PHOSPHATE PATHWAY (OXIDATIVE BRANCH)%HUMANCYC%OXIDATIVEPENT-PWY pentose phosphate pathway (oxidative branch) G6PD H6PD PGLS PGD FATTY ACID &ALPHA;-OXIDATION III%HUMANCYC%PWY66-388 fatty acid α-oxidation III ALDH3A2 FA2H HACL1 ADENINE AND ADENOSINE SALVAGE III%HUMANCYC%PWY-6609 adenine and adenosine salvage III HPRT1 ADAT3 PNP ADA CATECHOLAMINE BIOSYNTHESIS%HUMANCYC%PWY66-301 catecholamine biosynthesis PNMT DDC DBH THYMINE DEGRADATION%HUMANCYC%PWY-6430 thymine degradation DPYSL4 DPYSL5 DPYSL2 DPYS DPYSL3 DPYD CRMP1 UPB1 4-HYDROXY-2-NONENAL DETOXIFICATION%HUMANCYC%PWY-7112 4-hydroxy-2-nonenal detoxification GSTA5 GSTA4 GSTA3 GSTA1 GSTP1 THIO-MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-5963 thio-molybdenum cofactor biosynthesis MOCOS NAD BIOSYNTHESIS III%HUMANCYC%NAD-BIOSYNTHESIS-III NAD biosynthesis III NMNAT1 NMNAT3 NMNAT2 NAMPT COENZYME A BIOSYNTHESIS%HUMANCYC%COA-PWY coenzyme A biosynthesis PPCS PPCDC COASY GLYCOLYSIS I%HUMANCYC%GLYCOLYSIS glycolysis I ENO3 VCAN GPI GAPDHS PGK1 PGK2 FBP1 FBP2 PGAM1 PGAM2 BPGM GAPDH TPI1 ALDOB ALDOA PKLR PFKL PKM PFKM PFKP ENO1 ENO2 N< I>-ACETYLGLUCOSAMINE DEGRADATION I%HUMANCYC%GLUAMCAT-PWY N< i>-acetylglucosamine degradation I GNPDA1 GNPDA2 AMDHD2 UDP-N< I>-ACETYL-D-GALACTOSAMINE BIOSYNTHESIS II%HUMANCYC%PWY-5514 UDP-N< i>-acetyl-D-galactosamine biosynthesis II GPI GALE GCK GNPDA1 GNPDA2 PGM3 GNPNAT1 UAP1 HKDC1 3-PHOSPHOINOSITIDE BIOSYNTHESIS%HUMANCYC%PWY-6352 3-phosphoinositide biosynthesis SACM1L PIK3CA PIK3C3 PI4K2A PIK3R4 PIK3R3 PIK3R2 PIK3R1 PIK3R6 PIK3R5 PIP5K1A PIP5K1B PIP5K1C CDIPT FIG4 PIKFYVE PI4KA PI4KB PI4K2B PIK3CD PIK3C2G PIK3CB PIK3C2A PIK3CG PIK3C2B PIP5KL1 PIP4K2B PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS III%HUMANCYC%PWY-6273 phosphatidylethanolamine biosynthesis III PTDSS2 SUPERPATHWAY OF GERANYLGERANYLDIPHOSPHATE BIOSYNTHESIS I (VIA MEVALONATE)%HUMANCYC%PWY-5910 superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate) FDPS GGPS1 HADHB ACAA1 ACAT2 ACAT1 IDI1 MVK HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 SORBITOL DEGRADATION I%HUMANCYC%PWY-4101 sorbitol degradation I SORD THYROID HORMONE BIOSYNTHESIS%HUMANCYC%PWY-6241 thyroid hormone biosynthesis TPO CTSD 4-AMINOBUTYRATE DEGRADATION I%HUMANCYC%PWY-6535 4-aminobutyrate degradation I ALDH5A1 ABAT GUANINE AND GUANOSINE SALVAGE I%HUMANCYC%PWY-6620 guanine and guanosine salvage I HPRT1 PNP LACTOSE DEGRADATION III%HUMANCYC%BGALACT-PWY lactose degradation III GLB1 ETHANOL DEGRADATION II%HUMANCYC%PWY66-21 ethanol degradation II ALDH3A2 ALDH2 ADH1B ACSS3 ACSS2 ACSS1 GLUTAMINE BIOSYNTHESIS I%HUMANCYC%GLNSYN-PWY glutamine biosynthesis I GLUL SPHINGOSINE AND SPHINGOSINE-1-PHOSPHATE METABOLISM%HUMANCYC%PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism ACER2 ACER1 ASAH1 ASAH2 SPHK2 SPHK1 PTGR1 SGPP2 SGPP1 CITRULLINE DEGRADATION%HUMANCYC%CITRULLINE-DEG-PWY citrulline degradation OTC SPERMINE BIOSYNTHESIS%HUMANCYC%ARGSPECAT-PWY spermine biosynthesis SMS AMD1 S-ADENOSYL-L-METHIONINE BIOSYNTHESIS%HUMANCYC%SAM-PWY S-adenosyl-L-methionine biosynthesis MAT2A MAT1A MAT2B GLUTATHIONE REDOX REACTIONS I%HUMANCYC%PWY-4081 glutathione redox reactions I GPX3 GPX6 GPX5 GSR GPX8 GPX7 GPX2 GPX1 GPX4 NAD SALVAGE PATHWAY II%HUMANCYC%NAD-BIOSYNTHESIS-II NAD salvage pathway II NT5C3B NT5E NT5C1B NMRK2 NMRK1 ACP6 ENPP1 PXYLP1 ENPP3 NUDT12 NMNAT1 NMNAT3 NMNAT2 ASPARAGINE DEGRADATION I%HUMANCYC%ASPARAGINE-DEG1-PWY asparagine degradation I ASPG ASRGL1 PRPP BIOSYNTHESIS I%HUMANCYC%PWY0-662 PRPP biosynthesis I PRPS2 PRPS1 PRPS1L1 CHOLESTEROL BIOSYNTHESIS III (VIA DESMOSTEROL)%HUMANCYC%PWY66-4 cholesterol biosynthesis III (via desmosterol) NSDHL CYP51A1 MSMO1 HSD17B7 LBR DHCR24 TM7SF2 SQLE EBP SC5D DHCR7 LSS FDFT1 ASPARTATE DEGRADATION II%HUMANCYC%MALATE-ASPARTATE-SHUTTLE-PWY aspartate degradation II GOT1L1 GOT1 GOT2 MDH1 MDH2 PROLINE BIOSYNTHESIS II (FROM ARGININE)%HUMANCYC%PWY-4981 proline biosynthesis II (from arginine) OTC OAT PYCR1 PYCR2 PYCR3 GLUTAMATE DEGRADATION III (VIA 4-AMINOBUTYRATE)%HUMANCYC%GLUDEG-I-PWY glutamate degradation III (via 4-aminobutyrate) GAD1 ALDH5A1 GAD2 ABAT PHOSPHATIDYLETHANOLAMINE BIOSYNTHESIS II%HUMANCYC%PWY4FS-6 phosphatidylethanolamine biosynthesis II ETNK1 CEPT1 SELENOI PCYT2 CHKB ETNK2 PENTOSE PHOSPHATE PATHWAY (NON-OXIDATIVE BRANCH)%HUMANCYC%NONOXIPENT-PWY pentose phosphate pathway (non-oxidative branch) TKTL1 RPE TALDO1 TKT TKTL2 RPIA FATTY ACID &BETA;-OXIDATION III (UNSATURATED, ODD NUMBER)%HUMANCYC%PWY-5137 fatty acid β-oxidation III (unsaturated, odd number) ECI1 ECI2 EHHADH GLUTAMATE REMOVAL FROM FOLATES%HUMANCYC%PWY-2161B glutamate removal from folates GGH NAD BIOSYNTHESIS II (FROM TRYPTOPHAN)%HUMANCYC%NADSYN-PWY NAD biosynthesis II (from tryptophan) TDO2 NMNAT1 KYNU HAAO QPRT AFMID NMNAT3 NMNAT2 KMO NADSYN1 D-MYO< I>-INOSITOL (1,3,4)-TRISPHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6364 D-myo< i>-inositol (1,3,4)-trisphosphate biosynthesis IPMK OCRL ITPKB SYNJ2 ITPKC MINPP1 SYNJ1 ITPKA INPPL1 PTEN INPP5B INPP5A INPP5D INPP5J INPP5K URACIL DEGRADATION II (REDUCTIVE)%HUMANCYC%PWY-3982 uracil degradation II (reductive) DPYSL4 DPYSL5 DPYSL2 DPYS DPYSL3 DPYD CRMP1 UPB1 PURINE NUCLEOTIDES DE NOVO< I> BIOSYNTHESIS II%HUMANCYC%PWY-841 purine nucleotides de novo< i> biosynthesis II PAICS GMPS ADSS1 ADSS2 PPAT PFAS IMPDH1 IMPDH2 GART ADSL ATIC TRIACYLGLYCEROL BIOSYNTHESIS%HUMANCYC%TRIGLSYN-PWY triacylglycerol biosynthesis AGPAT3 AGPAT4 GPAM LPCAT4 PLPPR2 GPAT4 MOGAT3 PLPPR3 LPCAT3 PLPPR4 GPAT3 MOGAT1 GPAT2 DGAT2 DGAT1 PLPP4 PLPP3 PLPP2 PLPP1 AGPAT5 MBOAT7 MBOAT1 MBOAT2 ABHD5 AGPAT1 AGPAT2 LCLAT1 GLUTATHIONE BIOSYNTHESIS%HUMANCYC%GLUTATHIONESYN-PWY glutathione biosynthesis GCLC GSS GCLM PYRIMIDINE RIBONUCLEOTIDES DE NOVO< I> BIOSYNTHESIS%HUMANCYC%PWY0-162 pyrimidine ribonucleotides de novo< i> biosynthesis CAD UMPS CANT1 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME2P1 SUPERPATHWAY OF CHOLESTEROL BIOSYNTHESIS%HUMANCYC%PWY66-5 superpathway of cholesterol biosynthesis FDPS GGPS1 HADHB ACAA1 ACAT2 NSDHL ACAT1 CYP51A1 MSMO1 IDI1 HSD17B7 MVK LBR TM7SF2 HMGCS1 IDI2 PMVK MVD HMGCR HMGCS2 LSS DHCR24 SQLE EBP SC5D DHCR7 FDFT1 SALVAGE PATHWAYS OF PYRIMIDINE RIBONUCLEOTIDES%HUMANCYC%PWY0-163 salvage pathways of pyrimidine ribonucleotides UCKL1 UCK2 UCK1 UPRT UPP2 UPP1 CDA AICDA NME2 NME3 NME4 NME5 NME1 NME6 NME7 NME2P1 GDP-MANNOSE BIOSYNTHESIS%HUMANCYC%PWY-5659 GDP-mannose biosynthesis GPI MPI PMM1 PMM2 GMPPB GMPPA CYSTEINE BIOSYNTHESIS HOMOCYSTEINE DEGRADATION%HUMANCYC%HOMOCYSDEGR-PWY cysteine biosynthesis homocysteine degradation CBS CTH ARGININE DEGRADATION VI (ARGINASE 2 PATHWAY)%HUMANCYC%ARG-PRO-PWY arginine degradation VI (arginase 2 pathway) ARG2 OAT ARG1 PYCR1 PYCR2 PYCR3 4-HYDROXYPHENYLPYRUVATE BIOSYNTHESIS%HUMANCYC%PWY-5886 4-hydroxyphenylpyruvate biosynthesis TAT SEROTONIN DEGRADATION%HUMANCYC%PWY-6313 serotonin degradation ALDH3A2 SULT1A4 SULT1A2 MAOB ALDH2 MAOA ADH1B ADH6 UGT2B10 SULT1A1 L-CARNITINE BIOSYNTHESIS%HUMANCYC%PWY-6100 L-carnitine biosynthesis TMLHE BBOX1 ALDH9A1 DERMATAN SULFATE DEGRADATION (METAZOA)%HUMANCYC%PWY-6576 dermatan sulfate degradation (metazoa) HYAL1 HEXA IDUA SPAM1 &BETA;-ALANINE DEGRADATION I%HUMANCYC%BETA-ALA-DEGRADATION-I-PWY β-alanine degradation I ALDH6A1 ABAT TRNA SPLICING%HUMANCYC%PWY-6689 tRNA splicing TSEN2 TSEN54 TSEN34 TSEN15 TRPT1 EPOXYSQUALENE BIOSYNTHESIS%HUMANCYC%PWY-5670 epoxysqualene biosynthesis SQLE FDFT1 CREATINE-PHOSPHATE BIOSYNTHESIS%HUMANCYC%PWY-6158 creatine-phosphate biosynthesis CKMT2 CKM CKMT1B CKB GLYCEROL-3-PHOSPHATE SHUTTLE%HUMANCYC%PWY-6118 glycerol-3-phosphate shuttle GPD2 GPD1 GLUTAMATE DEGRADATION X%HUMANCYC%PWY-5766 glutamate degradation X GLUD1 GLUD2 PURINE RIBONUCLEOSIDES DEGRADATION TO RIBOSE-1-PHOSPHATE%HUMANCYC%PWY0-1296 purine ribonucleosides degradation to ribose-1-phosphate ADAT3 PNP ADA &ALPHA;-TOCOPHEROL DEGRADATION%HUMANCYC%PWY-6377 α-tocopherol degradation CYP4F2 TYROSINE DEGRADATION I%HUMANCYC%TYRFUMCAT-PWY tyrosine degradation I GSTZ1 TAT HGD FAH HPD THREONINE DEGRADATION II%HUMANCYC%THREONINE-DEG2-PWY threonine degradation II GCAT ACYL CARRIER PROTEIN METABOLISM%HUMANCYC%PWY-6012 acyl carrier protein metabolism AASDHPPT ARGININE BIOSYNTHESIS IV%HUMANCYC%ARGININE-SYN4-PWY arginine biosynthesis IV ASL ASS1 OTC OAT GLUD1 GLUD2 TREHALOSE DEGRADATION II (TREHALASE)%HUMANCYC%PWY0-1182 trehalose degradation II (trehalase) GALM GCK TREH HKDC1 TETRAHYDROBIOPTERIN BIOSYNTHESIS II%HUMANCYC%PWY-5664 tetrahydrobiopterin biosynthesis II GCH1 SPR PTS SUPEROXIDE RADICALS DEGRADATION%HUMANCYC%DETOX1-PWY superoxide radicals degradation SOD1 TYRP1 CAT SOD2 SOD3 &GAMMA;-GLUTAMYL CYCLE%HUMANCYC%PWY-4041 γ-glutamyl cycle OPLAH CNDP2 GGCT DPP8 ANPEP GGT1 GCLC GSS GCLM GGT7 GGT6 GGT3P GGT2 ACETATE CONVERSION TO ACETYL-COA%HUMANCYC%PWY0-1313 acetate conversion to acetyl-CoA ACSS3 ACSS2 ACSS1 L-CYSTEINE DEGRADATION III%HUMANCYC%PWY-5329 L-cysteine degradation III MPST PYRIMIDINE RIBONUCLEOTIDES INTERCONVERSION%HUMANCYC%PWY-5687 pyrimidine ribonucleotides interconversion CANT1 NME2 CTPS2 NME3 CTPS1 NME4 NME5 NME1 NME6 NME7 CMPK1 CMPK2 NME2P1 1D-MYO< I>-INOSITOL HEXAKISPHOSPHATE BIOSYNTHESIS II (MAMMALIAN)%HUMANCYC%PWY-6362 1D-myo< i>-inositol hexakisphosphate biosynthesis II (mammalian) ITPK1 IPMK OCRL ITPKB SYNJ2 ITPKC SYNJ1 ITPKA INPPL1 IPPK INPP5B INPP5A INPP5D INPP5J INPP5K CHOLESTEROL BIOSYNTHESIS II (VIA 24,25-DIHYDROLANOSTEROL)%HUMANCYC%PWY66-3 cholesterol biosynthesis II (via 24,25-dihydrolanosterol) NSDHL CYP51A1 MSMO1 HSD17B7 LBR DHCR24 TM7SF2 SQLE EBP SC5D DHCR7 LSS FDFT1 MOLYBDENUM COFACTOR BIOSYNTHESIS%HUMANCYC%PWY-6823 molybdenum cofactor biosynthesis MOCS2 NFS1 MOCS3 GPHN SULFATE ACTIVATION FOR SULFONATION%HUMANCYC%PWY-5340 sulfate activation for sulfonation PAPSS2 PAPSS1 GLYCINE BIOSYNTHESIS I%HUMANCYC%GLYSYN-PWY glycine biosynthesis I SHMT2 SHMT1 METHYLGLYOXAL DEGRADATION VI%HUMANCYC%MGLDLCTANA-PWY methylglyoxal degradation VI LDHD CERAMIDE DEGRADATION%HUMANCYC%PWY-6483 ceramide degradation ASAH2 GLYCOGEN DEGRADATION III%HUMANCYC%PWY-5767 glycogen degradation III PGM2 PYGB PGM5 AGL PGM1 PYGM PYGL MGAM GAA CITRULLINE-NITRIC OXIDE CYCLE%HUMANCYC%PWY-4983 citrulline-nitric oxide cycle ASL ASS1 NOS2 NOS3 NOS1 ALPHA6BETA4INTEGRIN%IOB%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DSP DST RPSA PRKCA YWHAZ PIK3CA ITGA6 PLEC COL17A1 LAMA5 CD151 SHC1 LAMA1 SRC LAMA3 PIK3R3 PIK3R2 PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA2 CLCA1 FYN SFN EIF4E SMAD2 YES1 LAMB3 BAD LAMB2 DKFZp666O0110 ERBIN LAMB1 PTPN11 MTOR EIF6 ARHA GRB2 TP73 ANDROGENRECEPTOR%IOB%ANDROGENRECEPTOR AndrogenReceptor FOXA1 RB1 hCG_16983 CCNH AHR NR3C1 HEL-S-89n HEL-S-125m UXT CCND3 CCND1 ZMIZ1 ZMIZ2 PP2150 EP300 KAT7 HEL-S-162eP GTF2F1 GTF2F2 PIAS2 RUNX2 PIAS1 RUNX1 CCNE1 CDC37 PRKD1 IL6ST HTATIP ZNF278 PXN PIK3R1 HEL-S-67p FOXO1 BRINP1 BAG1 LPXN MAGEA11 DKFZp686P15142 SMAD4 JUN POU2F1 UBE2I XRCC5 NONO PA2G4 NR0B2 CDK9 CDK7 SP1 MDM2 TCF4 RBAK GSK3B TGFB1I1 PTEN FHL2 BRCA1 EFCAB6 SIN3A DKFZp686G14213 CASP3 TRIM68 RAC3 NELFCD PELP1 APPL1 TGIF1 NCOA1 HEL-S-102 PARP1 PRMT1 NCOA6 HEL-S-72p ETV5 NCOR2 KAT2B SLC25A4 CEBPA DDC TMF1 HDAC1 SRC RNF4 NR2C2 HEL-S-99n RCHY1 RELA EGFR PSMC3IP PLAGL1 NSD2 FLNA PAK6 SRY SPDEF SVIL STAT3 RANBP9 PNRC1 CTNNB1 STUB1 VIP RAN BDNF%IOB%BDNF BDNF MAPK1 SIRPA FYN NCAM1 SH2B2 SH2B1 MAPK3 NTRK1 NGFR NTRK2 CDKL5 BAD KIDINS220 TSC2 FRS2 FRS3 GRIN2B MTOR SYN1 GRIN1 TIAM1 CREB1 RPS6KB1 CAMK4 CTNNB1 RAF1 GABRB3 SHC4 DKFZp434N101 GSK3B PRKAA2 SHC1 IRS1 KCNA3 FOXO3 ACACB RELB MAPK9 MAPK8 MAPK7 EIF4EBP1 IGF2BP1 PTK2B CCR1%IOB%CCR1 CCR1 CCL14 SRC CCL3L3 PXN RELA CCL15-CCL14 GNA14 MAPK9 MAPK8 CCL8 CCL7 CCL5 CCL4 CCL3 MAPK1 PTK2B CCL16 MAPK3 JAK1 CCR1 CCL23 STAT1 STAT3 DKFZp666O0110 MAPK14 NFKB1 CREB3 ZAP70 CCL26 CCR7%IOB%CCR7 CCR7 MAPK10 MAPK9 MAPK8 RPS6KB1 HEL-S- MAPK1 PTK2B CCR7 CCL19 MAPK3 DKFZp434N101 GSK3B MAP2K4 CCL21 ADRB2 MAPK14 FOXO3 MTOR RELA FOXO1 CCR9%IOB%CCR9 CCR9 JAK3 MAPK3 HEL70 CCL25 GSK3B ITGA4 RDX MAPK14 FOXO1 MAPK8 RPS6KB1 MAPK1 MADCAM1 CD226 ITGB7 EZR CD40%IOB%CD40 CD40 PIK3R1 IKBKB MAPK9 MAPK8 MYC PLCG2 MAPK1 FYN STAT6 JAK3 MAPK3 LYN JUN MAP2K1 SYK CHUK STAT1 STAT3 TRAF2 MAPK14 c-fgr NFKBIA TRAF3 LCK BIRC3 CXCR4%IOB%CXCR4 CXCR4 LCP2 RAF1 CRK USP14 SDC4 SRC PXN WAS CXCR4 PIK3R2 PIK3R1 CBL FOXO3 PRKCZ RELA FOXO1 EGFR GNAI1 GNA13 CDC42 SOCS3 PAK1 SOCS1 INPP5D STAT4 PLCG2 PTK2B MAPK1 FYN MAPK3 LYN STAT5B VCAM1 FYB1 BAD STAT1 STAT2 DKFZp666O0110 LIMK1 STAT3 PTPN11 NFKB1 ESR2 NFKBIA CXCL12 PTPRC ARHA RPS6KB1 ACKR3 CTNNB1 PTPN6 NFKBIB ATF1 DKFZp434N101 GSK3B ITK ARRB2 CRKL IKBKB RPS6KA3 HEL-S- RPS6KA2 PIM1 HEL-S-1 RAC1 CCR5 JAK3 JAK1 NCK1 MAP2K3 MAP2K1 MAP2K2 SYK ITGA4 CHUK HEL-S-72p RPS6 TYK2 VAV1 VAV2 ZAP70 DOK1 CREB1 LCK TFF2 EGFR1%IOB%EGFR1 EGFR1 SCAMP3 KIAA1217 GAREM1 ZFYVE16 PRKAR1A PARD3 PRKD1 RBCK1 TLN1 RIN1 PFN1 EPHA1 EPHA2 GRB7 SDC4 CTBP1 STXBP1 SH2D2A SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP DKFZp686J04131 PRKCZ MYL12B SLC5A5 MYO6 PLCG2 CXNK2 COX2 S100A14 STX4A SNX5 S100A10 LYN VASP STAT5B JUN JUND JUP HEL107 INSR SIAH2 SIAH1 BRAF PTK6 CDC2 SMU1 CYLD WNK1 TRIP6 SDC1 GRB2 CALM2 CC2D1A PYGB ARF4 RPLP0 CLTC CLTA AP2A1 PTPRK WASL SHB LIMD1 ARHGAP5 PTPRF PS1TP5BP1 OTUD6B ENSA RAC1 PLEKHN1 HRAS APPL2 JAK1 APPL1 VAV3 SERPINB3 CDV3 ANXA1 ANXA2 PGAM1 ANXA4 MINK1 TYK2 GAB2 EPS15L1 FOS DKFZp686K0257 VAV1 VAV2 PLSCR1 CEACAM1 GPRC5A KIT ARHGEF5 CSTB HEL-S-87p PHLPP1 AHNAK HTT NEDD9 RPS27L PRKX SNX33 RELA EGFR DKFZp686B23205 PAK1 PDZD11 ADRBK1 AP2S1 CD59 FLNB RPS2 LDLR MPZL1 /KNS-.3 MAP3K2 GIT2 MAP3K1 CAVIN1 STAT1 CAVIN2 STAT2 DKFZp686O0451 STAT3 DKFZp666O0110 HUWE1 PLEKHA5 ERBIN PLEKHA6 HIPK2 DCBLD2 ITCH KRT18 ARHA AXL NEDD4 EPPK1 PKN2 FRK SH3GL3 NDUFA13 PRAG1 CTNND1 INPPL1 ARHGAP35 LAPTM4A C11orf52 STK11 CYSRT1 HEL-S- GRB14 CDH2 GRB10 SIRPA hCG_1991735 KRT6A MAGI1 MAP2K3 RALBP1 KIRREL1 MAP2K1 MAP2K2 DYRK1A DYRK1B PRPF4B EEF1A1 DOK1 TOM1L2 ADAM17 HGS EEF1A2 HAT1 PKP2 ELMO2 ADAM9 PKP4 PKP3 RAF1 PHLDB2 STAM2 COL17A1 KHDRBS1 SHC1 HEL-S-132P PXN DAPP1 LPP FOXO1 PLD2 EFNB2 SOCS3 SDCBP ATXN2 SOCS1 UBB HNRNPDL CALD1 CASKIN2 EIF4EBP1 ABL2 RIPK1 MAP2K5 SMAD2 HEL-S-94n CAV2 TNK2 CRIM1 HEL-S-133P RFXANK NFKB1 DKFZp686A13234 PTPRE CDK5 PTPRA SP1 CDK2 ALB BCL2 RAB5A EIF4G1 DKFZp434N101 ITGB1 HEL-S-112 GSK3B DYRK4 DYRK3 GSK3A DOCK4 DDX3X USP31 ITGB4 CALCOCO2 HEL-S-115 PTEN PIK3CD PIK3C2B RBM3 CASP9 NCK2 FLOT1 FLOT2 HEL-S-1 HNRPA1 CCDC50 NCK1 TGIF1 ACTR3 DSP ACTR2 PDCD6IP KSR1 PDPK1 -4 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 PIK3CA LCK PEAK1 MYH9 DSG2 SOS1 CRK SOS2 DOCK1 PLEC SLC25A6 CEBPA PRKAA1 CEBPB RALB PRKAA2 SRC WBP2 HDAC1 MVP RGS16 CAMK2A ITLN2 ASAP1 SRI ATP1A1 TENC1 CBL CDC42 MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 REPS2 SLITRK6 MAPK1 PTK2B FYN CSK RBBP7 MTA2 PDLIM4 MAPK3 SH2B1 SNCA PTPN1 PTPN18 PPP1R14B BAD EGF SPRY4 PTPN11 PPP2R3A MAPK14 BAIAP2 MTOR RPS6KB1 DKFZp451F1115 FAM62A SPRY2 PTPN6 TIEG2 SPRY1 DNCL1 PTPN5 NECTIN1 ZPR1 SPG20 ATF1 ITSN2 USP6NL ERRFI1 APP RPL30 AHCYL1 ZDHHC5 HEL113 ARAF CBLC HEL114 KIAA0142 ANTXR1 CRKL RPS6KA3 DKFZp434G2016 BAIAP2L1 RPS6KA5 SNRPD2 TFG UBASH3B TRIM29 RPS6KA2 MYC RPS6KA1 PLCE1 EPHB2 ANKS1A TNS4 TNS3 RPS10 EPHB1 SLC12A7 EPHB4 TNS1 EPHB3 EPHA4 PRKCI PRKCB ACTN1 KRT7 SCRIB FRS2 PRKCA KRT5 ACTN4 EPO%IOB%EPO EPO CRKL MAPK9 MAPK8 RPS6KA5 BCL2L11 INPP5D H2BC21 PLCG2 MAPK1 SH2B2 PAG1 MAPK3 LYN MAP4K1 STAT5B JUN MAP2K1 MAP2K2 SYK STAT1 BAD DAPK2 STAT3 PTPN11 BRAF GAB2 EPOR VAV1 MTOR NFKBIA HCLS1 RAF1 SGK1 DKFZp434N101 GSK3B GSK3A SHC1 GATA4 PIK3R2 PIK3R1 FOXO4 CBL FOXO3 GATA1 FOXO1 FAS%IOB%FAS Fas CASP6 FASTK CASP3 CASP4 ARHGDIB XPO5 CDC27 RAC1 MAP3K5 CAST HEL-S-102 DFFA MAP2K1 MAP2K2 RFC1 CSNK2A1 PARP1 RIPK2 ANXA4 TRAF2 UBE4B TRAF1 CSNK1E EIF3S1 LCK TRAF3 CSNK2B TCP1 BTK EZR RAF1 PLEC GTF3C3 PARG ROCK1 UBA7 SATB1 DIABLO PRKDC MAX USO1 GLRX STK4 EGFR RELA DEDD2 CDC42 MAPK9 MAPK8 MAPK1 CD59 FYN RIPK1 FADD DEDD EIF4B MAPK3 LYN CASP8AP2 MBD4 TIA1 MAP3K1 UBE2I CSNK1A1 INSR EIF2AK2 HEL103 MAPK14 BMX EIF2S1 HEL-S-283 WEE1 STK24 TNFSF6 NEDD4 BCL2 BAX PTPN6 PKN2 PKN1 BCL2L1 GSK3B hCG_16983 NUMA1 FAF1 HEL113 hCG_20684 PARK2 IGF1R CASP9 TIAL1 AIFM1 CASP10 FLK2 FLT3%IOB%FLK2 FLT3 FLK2 FLT3 STAT3 PTPN11 GAB2 CBL FOXO3 CREB1 INPP5D MAPK1 MAPK3 LYN ATF1 ATF2 CEBPA STAT5B JUN BAD FLT3 SHC1 G-CSF%IOB%G-CSF G-CSF LYN STAT5B PRKCI SYK CISH BAD STAT1 STAT3 PTPN11 TYK2 GAB2 SYP CSNK1E MAPK14 VAV1 TEC LCK CDK2 IL3RA DKFZp434N181 REL GRB2 GSK3B CSF3 GSK3A POM121 NOTCH1 CSF3R CDKN1B SHC1 PLA2G1B CBL SOCS3 HEL-S- FTH1 INPP5D RPS6KA1 MAPK1 MAPK3 JAK1 GDNF%IOB%GDNF GDNF RAF1 CRK ATF1 DKFZp434N101 RET SRC SHC1 PXN PIK3R1 CBL RPS6KA3 MAPK7 MAPK1 PTK2B FYN MAPK3 JUN MAP2K1 MAP2K2 DKFZp666O0110 GAB2 CDC2 NFKBIA DOK1 CREB1 DOK4 RPS6KB1 DOK5 DOK6 GM-CSF%IOB%GM-CSF GM-CSF MAP2K6 LYN STAT5B TGFB1 YES1 BAD STAT1 STAT3 PTPN11 MAPK14 NFKB2 NFKBIA TEC PTPRC RPS6KB1 FES PTPN6 GRB2 MAD2L1 DKFZp434N101 GSK3B GSK3A hCG_16983 CSF2 CRKL IKBKB HEL-S-164nA HEL-S- RPS6KA2 EPHB2 JAK3 JAK1 MAP2K3 MAP2K1 MAP2K2 SYK PARP1 CHUK HEL-S-269 PRKCA YWHAZ VAV1 TGFBR3 CREB1 KIT RAF1 PFN1 EZR STAM2 SHC1 PXN CSF2RB PIK3R2 PIK3R1 FOXO3 CBL HEL-S-67p CSF2RA PRDX3 MAPK9 MAPK8 MAPK7 MAPK1 SH2B2 MAPK3 HEDGEHOG%IOB%HEDGEHOG Hedgehog MED6 KIF27 SKI MED23 CDK8 SMO CTNNB1 GAS1 HEL2 DHH SDC2 HHIP IHH ARRB2 NR2E1 GLI3 MED12 CCNB1 SHH SIN3A ADRBK1 RAB23 SUFU BOC SAP18 CDON MED1 SMAD1 CREBBP PTCH1 PTCH2 DYRK1A KIF7 ID%IOB%ID ID PAX2 ELK3 RBL2 RBL1 IFI16 PSMD4 PAX8 ID2 MYOD1 ID1 CDK2 ID4 MYF6 ID3 HES1 TCF3 ATF3 MYF5 MYOG RB1 TCF7L2 TCF12 PAX5 IFN-ALPHA%IOB%IFN-ALPHA IFN-alpha ARHGAP30 RPS6KB1 PRKCQ CRK IFNAR1 IRS1 CBL FOXO1 CRKL RPS6KA5 ERBB3 STAT4 EIF4EBP1 STAT6 EIF4B JAK1 MAP2K6 MAP2K3 IFNAR2 STAT5B MAP2K4 STAT1 STAT2 STAT3 RPS6 TYK2 MAPK14 MTOR VAV1 TNFRSF10D NFKBIA ZAP70 IFN-GAMMA%IOB%IFN-GAMMA IFN-gamma STAT3 MAPK14 VAV1 MAPK11 CREB1 IRF1 IRF2 IRF8 PRKCQ RAF1 CRK MAP3K11 GSK3B CEBPB SPI1 SRC CBL EGFR CRKL HOXA10 MAPK8 PLCG2 MAPK1 PTK2B STAT6 EIF4B MAPK3 JAK1 STAT5B JUN STAT1 IFNGR1 PRKCE STAT2 RPS6 KITRECEPTOR%IOB%KITRECEPTOR KitReceptor PIK3R1 CBL RELA Pe1Fe6 PAK1 MAPK8 SOCS1 MITF-C INPP5D EIF4EBP1 MAPK1 FYN SOCS6 MPDZ SH2B3 SH2B2 MAPK3 SOCS5 LYN DKFZp686J1568 STAT5B JUN YES1 BAD STAT1 STAT3 NFATC2 PTPN11 TNFRSF10A MAPK14 c-fgr EPOR MTOR KITLG TEC RPS6KB1 FES BRDG1 GRB2 PTPN6 GRAP IL7R LAT MAD2L1 DKFZp434N101 PTPRU GSK3B ATF2 GSK3A WIPF1 CLTC CRKL GYS1 SPRED1 RPS6KA1 GRB10 EP300 JAK3 HRAS ACTR2 MAP2K1 MAP2K2 PRKCB RPS6 MATK PRKCA GAB2 VAV1 DOK1 PIK3CA KIT BTK SOS1 RAF1 CRK GRB7 SHC1 SRC WAS PIK3R2 CSF2RB LEPTIN%IOB%LEPTIN Leptin LEPR MAPK1 ITGAV JAK3 SOCS7 MAPK3 MAP2K6 SH2B1 MAP2K3 HEL-S-102 STAT5B MAP2K1 MAP2K2 STAT1 PRKCE STAT3 HEL-S-269 DKFZp666O0110 RPS6 PTPN11 MAPK14 NFKB1 RPS6KB1 SP1 LEP MAPKAPK2 PDE3A GRB2 RAF1 ATF2 GSK3B KHDRBS1 GSK3A ITGB5 IRS1 PTEN PIK3R2 SLC2A4 PIK3R1 PRKCZ EGFR CFL2 RPS6KA2 M-CSF%IOB%M-CSF M-CSF DKFZp434N101 hCG_16983 CSF1 ITGB3 HEL113 INPPL1 SLA2 ETS2 PSTPIP2 GRAP2 ITGAV JAK1 MAP2K1 SCAP2 MAP2K2 PRKCE RPS6 GAB3 hCG_2011153 GAB2 TYK2 RAF1 SOS1 KHDRBS1 CSF1R SHC1 SRC PXN PIK3R1 CBL PPP2CA MITF-C INPP5D PLCG2 EIF4EBP1 MAPK1 PTK2B RIPK1 FADD MAPK3 LYN STAT5B STAT1 STAT3 DKFZp666O0110 PTPN11 RPS6KB1 RPS6KB2 PTPN6 GRB2 MAJN NGF%IOB%NGF NGF IRAK1 SP1 NCL RPS6KA1 MAPK1 SH2B1 MAPK3 NTRK1 DKFZp434N101 MAP2K1 PRKCI MAP2K2 SHC1 BAD BRAF PTPN11 FRS2 CREB1 NOTCH%IOB%NOTCH Notch BLOC1S1 MAPK1 HES1 HIVEP3 HES5 MAPK3 JAG2 SPEN SMAD1 SMAD4 STAT3 WDR12 NFKB1 ITCH SNW1 CNTN1 TCF3 GSK3B APP MAML2 MAML1 FHL1 DKFZp586H0919 RBPJ YY1 LFNG HEY1 SIN3A POFUT1 HEY2 MAGEA1 EP300 CIR1 SKP2 SKP1 DKFZp762E1511 PSENEN HES6 MEF2C FBXW7 ADAM10 RBX1 SAP30 NCOR2 KAT2B ADAM17 NCOR1 NOV LCK MFNG NUMB DKFZp434N181 NOTCH3 HDAC2 NOTCH1 HDAC1 PSEN2 DTX1 FURIN PIK3R2 PIK3R1 PSEN1 ASCL1 RELA DLL3 DLL4 APH1B TGF_BETA_RECEPTOR%IOB%TGF_BETA_RECEPTOR TGF_beta_Receptor SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 DKFZp781N011 NUP153 SMAD6 CDC2 CDK6 SNW1 COPS5 CDK4 SP1 CDK2 GRB2 DYNLRB2 DCP1A TP73 ACVRL1 CDKN1A CITED1 DKFZp451O0517 BRCA1 CTCF ARRB2 MED15 XPO4 SUMO1 MAP4K1 NCOA1 TGIF1 HEL-S-72p AXIN1 AXIN2 FOS UCHL5 TGFBR1 TGFBR2 PJA1 RBL2 TGFBR3 KAT2B ZEB2 TFDP1 EIF3S2 RBL1 TFDP2 SOS1 CRK CD44 ENG CAMK2D ROCK1 HDAC1 CAMK2A PPP2CA MAPK8 FZR1 PARD6A STAMBPL1 MAPK1 E2F4 E2F5 CAMK2G DYNC1I1 MAPK3 NR1i1 NFYA NFYB NFYC DKFZp666O0110 ERBIN MAPK14 PML FKBP1A SKI MAP3K7IP1 ITCH ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 DKFZp586H0919 UBE2D1 PPP2R2A NR2A1 HOXA9 STK11 CDC23 FNTA CCND1 MYC CDC27 EP300 SNIP1 SOX9 JUNB MAP3K7 RNF111 VPS39 SKP1 MAP2K3 NUP214 MEF2C PRKCB FOXH1 RUNX2 PIAS2 RBX1 PIAS1 DKFZp762H177 EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 PARD3 ANAPC5 RAF1 ATF3 ANAPC1 CSNK1G2 ANAPC2 DDX5 SHC1 SDC2 FOXG1 PXN PIK3R2 FOXO4 PIK3R1 FOXO3 ANAPC10 FOXO1 CCNB2 SNX4 SNX1 SNX2 DVL1 SKIL THROMBOPOIETIN%IOB%THROMBOPOIETIN Thrombopoietin MPL MAPK1 FOXO3 MAPK3 ATXN2L STAT5B MAP2K1 SHC1 STAT3 TIE1 TEK%IOB%TIE1 TEK TIE1 TEK FOXO1 PAK1 FES MAPK1 RAF1 MAPK3 NCK1 STAT5B GRB7 MAP2K1 MAP2K2 SHC1 PXN DKFZp666O0110 BMX MAPK14 TNFALPHA%IOB%TNFALPHA TNFalpha USP2 DOK1 CDC34 TXLNA FANCD2 CDC37 MAPKAPK2 TRIB3 FKBP5 NSMAF COPB2 PSMD12 PSMD13 KIAA0287 TNFRSF11A DKFZp686J04131 PRKCZ GLG1 BAG4 BRINP1 G3BP2 RIPK1 FADD MAP2K5 MAP2K6 CREBBP JUN UBE2I CRADD SEC16A DKFZp781N011 DKFZp566E044 TRAPPC9 MCC NFKB1 NFKB2 SMARCA4 NFKBIA CDK9 IRAK1BP1 COPS5 REL TAB3 ALPL NFKBIE MAP3K11 NFKBIB DDX3X HSP90AB1 MCM7 FAF1 TRADD TNFAIP3 IKBKAP HMGB1 IKBKB PPP6C SUMO1 YWHAQ BCL7A CASP10 NKIRAS1 PPP1R13L NKIRAS2 CASP3 NFKBIZ HEL-S-1 IKBKG IKBKE YWHAG HEL-S-102 SYK RIPK3 CHUK HEL-S-72p ACTL6A -4 TRAF2 COMMD1 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 TRAF4 RASA3 POLR1A TRAF3 MUXA TRAF6 POLR1C TRAF5 POLR1D PFDN2 MCM5 BIRC2 HDAC2 SRC HDAC1 USP11 AKAP8 MTIF2 NR2C2 TANK RELA EGFR RELB MAPK9 MAPK8 TIFA FLNA MAPK1 POLR2H MAPK3 POLR2L SMARCE1 MAP3K2 MAP3K1 RNF25 STAT1 DKFZp666O0110 PTPN11 ZA20D2 MAPK14 LRPPRC PML KTN1 MAP3K7IP1 RPS6KB1 PRC1 TNIP2 PSMC1 BAX TBKBP1 PDCD2 PKN1 RPL4 RB1 hCG_16983 HEL2 RPL30 TNF-alpha UBE2D2 UBE2D3 hCG_20684 MLC1 RPL8 DCAF7 RPL6 HEL-S-89n MYLK FBL PSMD6 RPS6KA5 PSMD7 TBK1 PSMD2 PSMD3 KPNA6 DPF2 PAPOLA PSMD1 TNFRSF8 MAP3K8 AZI2 RPS11 KPNA2 MAP3K7 KPNA3 RPS13 GTF2I SKP1 SMARCC1 MAP2K1 SMARCC2 CSNK2A1 FBXW7 TNFSF1%IOB%TNFSF1 TNFSF1 LTB JUN TNFRSF19 TNFRSF1B RELA NFKB1 RELB NFKB2 TNFRSF1A NFKBIA TRAF3 TRAF5 LTA TNFRSF14 IKBKG LTBR TNFSF3%IOB%TNFSF3 TNFSF3 JUN TRAF2 TNFRSF1B RELA NFKB1 RELB NFKB2 TNFRSF1A NFKBIA TRAF3 TRAF5 LTA LTBR LTB TNFSF8%IOB%TNFSF8 TNFSF8 TRAF5 REL TNFRSF8 MAPK1 TNFSF8 NFKBIB CHUK TRAF2 TRAF1 MAPK14 DKFZp686J04131 RELA NFKB1 RELB NFKB2 IKBKB NFKBIA TRAF3 TRAIL%IOB%TRAIL TRAIL hCG_20684 TNFRSF11B BCL10 CBL RELA MAPK9 MAPK8 AIFM1 CASP10 CHEK2 CASP3 TNFSF10 MAPK1 RIPK1 BAK1 IKBKG FADD MAP3K7 MAPK3 MCL1 JUN APAF1 CSNK2A1 PARP1 DKFZp686N0152 TNFRSF10C TRAF2 TNFRSF10A MAPK14 NFKB1 TNFRSF10D NFKBIA CREB1 CTNNB1 BAX CYCS ATM IRF5 DAP3 DKFZp686A24188 H2AX BEX3 hCG_16983 PRKAA1 DIABLO SRC PRKDC TRADD WNT%IOB%WNT Wnt DIXDC1 DKFZp586H0919 FZD10 DKFZp434G2016 FRAT1 FRAT2 SOX1 HEL-S- CCND1 CDH2 MAP3K7 MAP2K4 PRKCH WNT5B PRKCB PRKCE PRKCA CSNK1D CSNK1E DKK1 SFRP4 SFRP1 DAAM1 PRKCQ ROR1 ROR2 RAF1 PI4K2A CTBP2 CTBP1 NLK DVL1 DVL2 WNT1 WNT3 WNT4 FZD1 SMAD1 FZD3 JUN GCKR YES1 FZD2 JUP SETDB1 FZD5 WNT3A FZD4 FZD7 FZD9 FZD8 NFATC2 DKFZp781N011 BCL9 CDK6 PPP1R1B PIN1 CHRFAM7A TCF4 TCF3 GSK3B GSK3A ARRB2 DKFZp586M1622 STM7 RSPO3 HEL-S-1 RSPO1 RAC1 AXIN1 WNT9B KREMEN1 AXIN2 WNT9A PAX2 PPARG SRC LRP5 MESD LRP6 PPP2CA MAPK8 WNT11 WIF1 FRZB GPC3 MAPK1 MAPK3 TCF7L2 MAP3K1 CSNK1A1 RYK WNT7B WNT7A APC ARHA RPS6KB2 CTNNB1 PID_IL2_PI3K_PATHWAY%MSIGDB_C2%PID_IL2_PI3K_PATHWAY PID_IL2_PI3K_PATHWAY SGMS1 SHC1 PIK3R1 FOXO3 IL2RG PRKCZ RELA UGCG TERT SMPD1 MYC MYB RAC1 JAK3 JAK1 RPS6 PTPN11 GAB2 MTOR IL2 NFKB1 PIK3CA RPS6KB1 LCK IL2RA IL2RB BCL2 GRB2 SOS1 EIF3A BCL2L1 BIOCARTA_TERT_PATHWAY%MSIGDB_C2%BIOCARTA_TERT_PATHWAY BIOCARTA_TERT_PATHWAY MYC SP1 WT1 HDAC1 MAX SP3 ZNF42 PID_E2F_PATHWAY%MSIGDB_C2%PID_E2F_PATHWAY PID_E2F_PATHWAY CCNA2 RBL2 KAT2B KAT2A RBL1 TFDP1 TFDP2 CCNE2 CCNE1 CES8 CES3 CES2 CES1 CEBPA TYMS RBBP4 RBBP8 E2F2 E2F3 E2F4 WASF1 E2F5 E2F6 E2F7 MCL1 RANBP1 CREBBP RRM1 RRM2 CDKN2C CDKN2A HEL25 CDC6 CDC2 DHFR POLA1 RYBP CDK2 ATM TP73 MYC SP1 HDAC1 RB1 CDKN1A CDKN1B ORC1L TRRAP SERPINE1 BRCA1 UXT YY1 CCND3 TRIM28 EP300 MYBL2 TOPBP1 TK1 SULT2A1 APAF1 HEL126 SIRT1 HIC1 PID_P53_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P53_DOWNSTREAM_PATHWAY PID_P53_DOWNSTREAM_PATHWAY TP53INP1 DROSHA BAK1 TIGAR NR1i1 NFYA GDF15 NFYB NFYC ARID3A POU4F1 PML POU4F2 APC RFWD2 CARM1 CCNG1 BAX CEBPZ BCL2 BCL2L1 SP1 RB1 CDKN1A TRRAP SERPINE1 EP300 APAF1 HIC1 KAT2A TFDP1 E2F2 E2F3 MCL1 CREBBP TP73 FOXA1 CCNK STEAP3 HEL-S-130P CD82 PRDM1 PYCARD SESN1 FDXR TP63 BNIP3L S100A2 HGF TSC2 TAP1 PRKAB1 DKK1 MSH2 DDIT4 ATF3 EPHA2 DDX5 TGFA CCNB1 PCBP4 TP53BP2 PMAIP1 SFN SCN3B PLK3 ZNF385 JUN DKFZp686J1569 GADD45A SH2D1A TNFRSF10C LIF TNFRSF10A TNFRSF10D SMARCA4 TADA2B TP53I3 RGCC BCL6 JMY MDM2 SNAI2 BCL2L2 DKFZp686A24188 COL18A1 BTG2 PPP1R13B HEL-S-31 PTEN TRIAP1 CX3CL1 BBC3 PIDD1 CASP10 AIFM2 CASP6 BDKRB2 DGCR8 DUSP5 GPX1 EDN2 PRMT1 MMP2 opn SERPINB5 DDB2 hCG_27697 RNF144B VCAN RRM2B IRF5 HDAC2 PCNA BCL2A1 TYRP1 RPS27L HTT PPM1J NLRC4 AFP RCHY1 EGFR PERP PID_FANCONI_PATHWAY%MSIGDB_C2%PID_FANCONI_PATHWAY PID_FANCONI_PATHWAY H2AX BLM WDR48 FAAP24 BRCA2 BRIP1 CHEK1 USP1 HES1 NBN RFC3 RFC4 FANCM FANCL hCG_37731 RMI1 RFC2 TREX1 XRCC3 FANCA ATM RPA1 HUS1 MRE11A FANCC FANCB FANCE PALB2 FANCG FANCF RAD50 FANCD2 BRCA1 UBE2T RAD17 FAN1 RAD9A CENPS ATR TOPBP1 BIOCARTA_MEF2D_PATHWAY%MSIGDB_C2%BIOCARTA_MEF2D_PATHWAY BIOCARTA_MEF2D_PATHWAY CAPNS1 CAPNS2 MEF2D CALM2 HDAC1 HDAC2 EP300 HEL-S-72 PRKCB NFATC2 NFATC1 PRKCA CABIN1 PPP3CA PPP3CC BIOCARTA_PPARG_PATHWAY%MSIGDB_C2%BIOCARTA_PPARG_PATHWAY BIOCARTA_PPARG_PATHWAY NCOA1 MED1 RXRA LPL EP300 PPARG PPARGC1A CREBBP PID_TGFBR_PATHWAY%MSIGDB_C2%PID_TGFBR_PATHWAY PID_TGFBR_PATHWAY SHC1 PPP1R15A HEL2 PML ZFYVE9 DKFZp451O0517 CAMK2A PPP2R2A ARRB2 CTGF PPP2CA PARD6A DACT2 SKIL MAP3K7 SPTBN1 RNF111 EIF2A SMAD2 SMAD4 TGFB1 SMURF2 RPS6KB1 SMURF1 PDPK1 AXIN1 WWP1 TGFBR1 GRB2 TGFBR2 SOS1 FKBP1A TGFBR3 MAP3K7IP1 ITCH ZFYVE16 ARHA BAMBI CTNNB1 PID_SYNDECAN_4_PATHWAY%MSIGDB_C2%PID_SYNDECAN_4_PATHWAY PID_SYNDECAN_4_PATHWAY TACI ADAM12 FGFR1 RAC1 ARHA ITGB1 SDC4 LAMA1 LAMA3 TNC CXCR4 PLG TFPI THBS1 FGF2 SDCBP FGF6 MDK CCL5 ACTN1 FZD7 DKFZp666O0110 PRKCA NUDT16L1 MMP9 CXCL12 PID_LPA4_PATHWAY%MSIGDB_C2%PID_LPA4_PATHWAY PID_LPA4_PATHWAY RPS6KA5 CREB1 ADCY9 GNAL PRKCE ADCY3 LPAR4 ADCY1 ADCY8 ADCY6 PID_NECTIN_PATHWAY%MSIGDB_C2%PID_NECTIN_PATHWAY PID_NECTIN_PATHWAY PIK3R1 SRC ITGB3 PTPRM F11R CLDN1 CDC42 RAP1A RAC1 CTNNA1 ITGAV PIP5K1C hCG_1991735 FARP2 VAV2 AFDN RAPGEF1 PIK3CA TLN1 CRK NECTIN3 NECTIN2 NECTIN1 CTNNB1 DKFZp666O0110 PID_AURORA_B_PATHWAY%MSIGDB_C2%PID_AURORA_B_PATHWAY PID_AURORA_B_PATHWAY HEL25 HEL113 CDCA8 NCAPG HEL-S-34 KLHL13 AURKC SMC4 CENPA AURKB ARHA MYLK SMC2 AURKA PPP1CC SGOL1 DKFZp686K18126 SEPTIN1 KNTC2 NSUN2 KIF23 PPP2R5D KLHL9 INCENP NCL BIRC5 KIF20A tmp_locus_29 PID_ARF6_TRAFFICKING_PATHWAY%MSIGDB_C2%PID_ARF6_TRAFFICKING_PATHWAY PID_ARF6_TRAFFICKING_PATHWAY ADRB2 SLC2A4 INS PLD2 EDNRB ITGA4 ITGA2 AVPR2 ITGA1 MAPK8IP3 TSHR DKFZp762K123 ACAP1 DKFZp686P1551 BIN1 AGTR1 EXOC4 ITGA7 EXOC6 ITGA6 CTNNA1 EXOC5 ITGAV EXOC2 PIP5K1C VAMP3 EXOC1 ARF6 IL2RA CTNNB1 ITGB1 KNS2 RALA CTNND1 CLTC ASAP2 BIOCARTA_TGFB_PATHWAY%MSIGDB_C2%BIOCARTA_TGFB_PATHWAY BIOCARTA_TGFB_PATHWAY TGFBR1 TGFBR2 MAP3K7IP1 ZFYVE9 APC SKIL MAP3K7 EP300 MAP2K1 SMAD2 CREBBP MAPK3 SMAD4 TGFB1 PID_A6B1_A6B4_INTEGRIN_PATHWAY%MSIGDB_C2%PID_A6B1_A6B4_INTEGRIN_PATHWAY PID_A6B1_A6B4_INTEGRIN_PATHWAY SFN RXRA SHC1 PIK3R1 HEL2 RAC1 ITGA6 COL17A1 LAMA5 PIK3CA ITGB4 RPS6KB1 LAMA4 LAMC2 LAMC1 RXRB YWHAQ GRB2 ERBB3 ERBB2 HEL-S-1 HRAS RXRG YWHAG LAMB3 EGF LAMB2 ITGB1 LAMB1 YWHAZ LAMA1 IL1A LAMA3 PMP22 PRKCA EGFR BIOCARTA_MRP_PATHWAY%MSIGDB_C2%BIOCARTA_MRP_PATHWAY BIOCARTA_MRP_PATHWAY ABCC3 ABCC1 ABCB1 ABCB4 HEL-S-22 ABCB11 PID_EPHB_FWD_PATHWAY%MSIGDB_C2%PID_EPHB_FWD_PATHWAY PID_EPHB_FWD_PATHWAY NRAS EFNB3 RRAS MAPK1 EPHB2 EPHB1 EPHB4 NCK1 SHC1 EPHB3 PIK3R1 TF SYNJ1 KRAS SRC CDC42 RAP1A RAC1 MAP2K1 MAPK3 HEL-S-31 PIK3CA CRK GRB2 HRAS GRB7 ROCK1 PXN ITSN1 WASL EFNA5 KALRN DKFZp666O0110 EFNB2 EFNB1 PAK1 PID_MYC_PATHWAY%MSIGDB_C2%PID_MYC_PATHWAY PID_MYC_PATHWAY AXIN1 KAT2A MAX PML GSK3B TAF12 FBXW7 TAF10 TRRAP ACTL6A PPP2R5A MYC SUPT7L PPP2CA RUVBL2 RUVBL1 PIN1 SKP2 HTATIP CDKN2A BIOCARTA_PLCE_PATHWAY%MSIGDB_C2%BIOCARTA_PLCE_PATHWAY BIOCARTA_PLCE_PATHWAY ADRB2 RAP2B PRKAR1B PTGER1 ADCY1 PRKAR1A PRKACG PLCE1 PID_HIF1_TFPATHWAY%MSIGDB_C2%PID_HIF1_TFPATHWAY PID_HIF1_TFPATHWAY CREB1 TF MCL1 CREBBP CITED2 EPO HEL-S-30 BHLHE41 ADM RORA HK2 NR2A1 CA9 IGFBP1 EDN1 FOS HEL-S-68p ADFP TFF3 ENG ABCG2 HEL-S-87p BHLHB2 FURIN GATA2 HIF1A HEL-S-17 HDAC7 NT5E HMOX1 EGLN1 EGLN3 NOS2 BNIP3 DKFZp686O0451 HEL-S-133P DKFZp686P18130 GCK VEGFA PFKL COPS5 LEP NCOA1 ID2 JUN TERT SMAD4 SP1 SERPINE1 CXCR4 ABCB1 EP300 CXCL12 PID_NFKAPPAB_ATYPICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_ATYPICAL_PATHWAY PID_NFKAPPAB_ATYPICAL_PATHWAY CSNK2A1 SYK CSNK2A2 MAPK14 PIK3R1 IKBKB NFKBIA CSNK2B REL SRC RELA ARRB2 NFKB1 PIK3CA LCK PID_ERBB_NETWORK_PATHWAY%MSIGDB_C2%PID_ERBB_NETWORK_PATHWAY PID_ERBB_NETWORK_PATHWAY ERBB3 ERBB2 EGF NRG1 NRG2 AREG EREG BTC NRG3 ERBB4 NRG4 HBEGF TGFA EGFR BIOCARTA_EPHA4_PATHWAY%MSIGDB_C2%BIOCARTA_EPHA4_PATHWAY BIOCARTA_EPHA4_PATHWAY EPHB1 SELP LYN ACTA1 EPHA4 FYN ITGB1 PID_ENDOTHELIN_PATHWAY%MSIGDB_C2%PID_ENDOTHELIN_PATHWAY PID_ENDOTHELIN_PATHWAY MAPK1 EDNRB ADCY9 GNAL JUN PRKCE ADCY3 MAPK14 ADCY1 ADCY8 ADCY6 SRC CDC42 RAC1 MAP2K1 MAPK3 GNAZ GNAI3 GNAI1 CRK GNA14 MAPK8 EDNRA GNA15 GNA11 KPG_011 PTK2B MAP2K2 HRAS PRKCH TRPC6 EDN1 EDN3 EDN2 FOS GNAO1 ARHA SLC9A3 PLCB3 COL3A1 COL1A2 GNAQ PRKCQ RAF1 PLCB1 PLCB2 PRKCB PRKCA BIOCARTA_FREE_PATHWAY%MSIGDB_C2%BIOCARTA_FREE_PATHWAY BIOCARTA_FREE_PATHWAY HEL-S-64p HEL-75 IL8 TNF-alpha HEL-S-44 GPX1 XDH NFKB1 RELA BIOCARTA_CYTOKINE_PATHWAY%MSIGDB_C2%BIOCARTA_CYTOKINE_PATHWAY BIOCARTA_CYTOKINE_PATHWAY IL4 IL3 IL6 IL5 TXLNA IFNG IL9 IL17A IL1A IL8 TNF-alpha IL10 IFNA1 IL2 IL15 IFNB1 IL13 IL18 IL16 BIOCARTA_STRESS_PATHWAY%MSIGDB_C2%BIOCARTA_STRESS_PATHWAY BIOCARTA_STRESS_PATHWAY JUN MAP2K3 MAPK14 ATF1 IKBKB MAP2K4 NFKBIA MAP4K2 MAP3K1 CRADD RELA CHUK TRADD hCG_20684 TRAF2 DKFZp686J04131 TANK TNFRSF1A RIPK1 TNF-alpha IKBKG MAP2K6 NFKB1 MAPK8 PID_HIF1A_PATHWAY%MSIGDB_C2%PID_HIF1A_PATHWAY PID_HIF1A_PATHWAY COPS5 HIF1A EGLN1 EGLN2 EGLN3 HIF3A RBX1 OS9 ARD1A TCEB1 CDKN2A VHL HIF1AN PID_ANGIOPOIETIN_RECEPTOR_PATHWAY%MSIGDB_C2%PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PID_ANGIOPOIETIN_RECEPTOR_PATHWAY PLD2 MAPK1 NCK1 SHC1 MAPK14 PIK3R1 RELA AGTR1 RAC1 PTPN11 FYN MAPK3 NFKB1 PIK3CA RPS6KB1 CRK MAPK8 FOXO1 GRB14 DKFZp686H0575 GRB2 STAT5B ANGPT4 ANGPT2 ANGPT1 BMX ELF2 FES MMP2 ITGB1 CDKN1A PLG FGF2 GRB7 TNF-alpha PXN DKFZp666O0110 PAK1 PID_RAS_PATHWAY%MSIGDB_C2%PID_RAS_PATHWAY PID_RAS_PATHWAY NRAS RRAS GRB2 SOS1 HRAS PRKCE RASGRF1 DAB2IP KRAS RASAL1 PRKCZ hCG_22119 RASGRP4 RASGRP3 SYNGAP1 RASA4 RASA2 NF1 DKFZp781H1715 RIN1 SOS2 PRKCB PRKCA PLCE1 BIOCARTA_G2_PATHWAY%MSIGDB_C2%BIOCARTA_G2_PATHWAY BIOCARTA_G2_PATHWAY CDC2 YWHAQ ATM GADD45A CDKN1A BRCA1 MDM2 CDKN2D EP300 ATR PRKDC PLK1 CHEK1 MYT1 WEE1 CDC34 DKFZp686G14213 CHEK2 CCNB1 RPS6KA1 BIOCARTA_IL3_PATHWAY%MSIGDB_C2%BIOCARTA_IL3_PATHWAY BIOCARTA_IL3_PATHWAY CSF2RB IL3 IL3RA GRB2 PTPN6 STAT5B SOS1 HRAS SHC1 FOS RAF1 MAP2K1 MAPK3 BIOCARTA_IL2_PATHWAY%MSIGDB_C2%BIOCARTA_IL2_PATHWAY BIOCARTA_IL2_PATHWAY IL2RB GRB2 STAT5B SOS1 CSNK2A1 SYK HRAS JUN SHC1 FOS IL2RG RAF1 JAK3 JAK1 MAP2K1 IL2 MAPK3 LCK MAPK8 IL2RA PID_ERBB2_ERBB3_PATHWAY%MSIGDB_C2%PID_ERBB2_ERBB3_PATHWAY PID_ERBB2_ERBB3_PATHWAY NRAS CHRNA1 MAPK1 DOCK7 PIK3R3 PIK3CD PIK3R2 JUN SHC1 MAPK9 PIK3R1 CHRNE BAD STAT3 KRAS RNF41 SRC NRG1 NFATC4 NRG2 MAPK10 NF2 CDC42 RAC1 PTPN11 MAP2K1 MTOR MAPK3 PIK3CA MAPK8 GRB2 ERBB3 SOS1 ERBB2 MAP2K2 HRAS FOS RAF1 PID_IL2_STAT5_PATHWAY%MSIGDB_C2%PID_IL2_STAT5_PATHWAY PID_IL2_STAT5_PATHWAY IL4 CCNA2 SHC1 PIK3R1 IL2RG PRF1 CCND2 MYC FOXP3 CDK6 JAK3 TNFSF6 JAK1 LTA PTPN11 GAB2 IL2 PIK3CA LCK IL2RA IL2RB BCL2 DKFZp686H0575 GRB2 STAT5B SOS1 BCL2L1 SP1 CCND3 BIOCARTA_AKAP95_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP95_PATHWAY BIOCARTA_AKAP95_PATHWAY CDC2 PPP2CA PRKAG1 AKAP8 PRKACG DDX5 CCNB1 PID_PDGFRA_PATHWAY%MSIGDB_C2%PID_PDGFRA_PATHWAY PID_PDGFRA_PATHWAY GRB2 SOS1 CSNK2A1 IFNG JUN SHC1 PIK3R1 FOS ITGAV JAK1 DKFZp434N101 PDGFRA CAV3 SHB RAPGEF1 CRKL PIK3CA SHF CRK PID_REELIN_PATHWAY%MSIGDB_C2%PID_REELIN_PATHWAY PID_REELIN_PATHWAY CBL GRIN2B LRP8 DAB1 RELN CDK5 MAP1B NCK2 ARHGEF2 PIK3R1 MAP3K11 PAFAH1B1 CDK5R1 ITGB1 GSK3B RAP1A FYN RAPGEF1 CRKL PIK3CA LRPAP1 VLDLR MAPK8 BIOCARTA_P38MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_P38MAPK_PATHWAY BIOCARTA_P38MAPK_PATHWAY RPS6KA5 CREB1 SHC1 MAPK14 MAP2K4 MAP3K1 TRADD MYC TRAF2 CDC42 RAC1 RIPK1 MAP3K7 MAP2K6 TGFB1 TGFBR1 GRB2 HRAS MAX ATF2 HSPB2-C11orf52 MKNK1 MAP3K5 HMGN1 HEL-S-102 STAT1 DDIT3 MAPKAPK2 RAPGEF2 MAPKAPK5 BIOCARTA_RB_PATHWAY%MSIGDB_C2%BIOCARTA_RB_PATHWAY BIOCARTA_RB_PATHWAY CDC2 CDK2 ATM CDK4 CHEK1 MYT1 WEE1 RB1 DKFZp686G14213 BIOCARTA_MET_PATHWAY%MSIGDB_C2%BIOCARTA_MET_PATHWAY BIOCARTA_MET_PATHWAY MAPK1 JUN PIK3R1 STAT3 RAP1A PTPN11 ACTA1 MAP2K1 MAPK3 RAPGEF1 CRKL PIK3CA PTEN CRK MAPK8 GRB2 SOS1 PTK2B MAP2K2 HRAS FOS ITGB1 RAF1 HGF MAP4K1 DOCK1 PAK1 BIOCARTA_ACE2_PATHWAY%MSIGDB_C2%BIOCARTA_ACE2_PATHWAY BIOCARTA_ACE2_PATHWAY COL4A6 COL4A5 REN AGTR2 ACE2 COL4A2 CMA1 COL4A1 COL4A4 COL4A3 AGTR1 PID_P38_ALPHA_BETA_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_PATHWAY PID_P38_ALPHA_BETA_PATHWAY BLK RALB YES1 MAP3K7IP1 DUSP8 MAP2K3 MAPK14 DUSP16 c-fgr MAP2K4 MAPK11 DUSP10 TRAF6 SRC MAP3K12 CDC42 RAC1 RIPK1 LYN MAP2K6 FYN RALA LCK PAK1 BIOCARTA_STATHMIN_PATHWAY%MSIGDB_C2%BIOCARTA_STATHMIN_PATHWAY BIOCARTA_STATHMIN_PATHWAY CDC2 TSG101 CD3G CD3E CD3D UHMK1 HEL-S-89n MAPK13 CD2 RB1CC1 CAMK4 CD247 PRKAR1B PRKAR1A PRKACG CCNB1 BIOCARTA_41BB_PATHWAY%MSIGDB_C2%BIOCARTA_41BB_PATHWAY BIOCARTA_41BB_PATHWAY IL4 IFNG JUN MAPK14 IKBKB NFKBIA ATF2 MAP3K1 RELA CHUK MAP3K5 TRAF2 TNLG5A TNFRSF9 IL2 NFKB1 MAPK8 BIOCARTA_SALMONELLA_PATHWAY%MSIGDB_C2%BIOCARTA_SALMONELLA_PATHWAY BIOCARTA_SALMONELLA_PATHWAY CDC42 RAC1 WASF1 ACTA1 WASL PID_HNF3B_PATHWAY%MSIGDB_C2%PID_HNF3B_PATHWAY PID_HNF3B_PATHWAY INS CREB1 CEBPA CEBPB ACADVL ALAS1 CEBPD SLC2A2 NR3C1 HEL111 UCP2 NKX2-1 ACADM NR2A1 PCK1 CPT1A SP1 IGFBP1 HMGCS1 FOXA1 PKLR ABCC8 FOXF1 PDX1 APOA1 HNF1A CPT1C G6PC1 ALB ALDOB TCF2 NF1 FOXA3 FOXA2 AFP DKFZp686O0451 GCK PID_IL4_2PATHWAY%MSIGDB_C2%PID_IL4_2PATHWAY PID_IL4_2PATHWAY IL4 IL5 ITGB3 CEBPB STAT5B FES TFF3 PIGR SPI1 IRS1 IL13RA2 AID MYBL1 IL13RA1 ARG1 GTF3A OPRM1 FCER2 IRF4 RETNLB CCL11 PTPN6 ALOX15 THY1 SOCS3 SOCS1 STAT6 SHC1 CCL17 MAPK14 PIK3R1 SOCS5 EGR2 IL2RG HMGA1 PARP14 COL1A1 CD40LG CCL26 MYB BCL6 JAK3 JAK1 LTA SELP MTOR PIK3CA RPS6KB1 CBL GRB2 BCL2L1 SP1 COL1A2 IL10 PID_NCADHERIN_PATHWAY%MSIGDB_C2%PID_NCADHERIN_PATHWAY PID_NCADHERIN_PATHWAY FGFR1 PIK3R1 GRIA2 DAGLA LRP5 CDC42 Pe1Fe6 RAC1 DKFZp686I0746 CTNNA1 CDH2 CNR1 PIP5K1C CXNK2 PTPN11 DKFZp434N101 CAMK2G HEL-S-61 PTPN1 JUP GAP43 PIK3CA MYL2 MAPRE1 MAPK8 DAGLB AXIN1 ARHA CTNNB1 ROCK1 CTNND1 BIOCARTA_HIF_PATHWAY%MSIGDB_C2%BIOCARTA_HIF_PATHWAY BIOCARTA_HIF_PATHWAY ASPH VEGFA P4HB COPS5 HIF1A CREB1 JUN EP300 EDN1 HEL-S-133P VHL EPO PID_LYMPH_ANGIOGENESIS_PATHWAY%MSIGDB_C2%PID_LYMPH_ANGIOGENESIS_PATHWAY PID_LYMPH_ANGIOGENESIS_PATHWAY FLT4 GRB2 VEGFC MAPK1 SOS1 VEGFD CREB1 ITGA4 ITGA2 SHC1 ITGA1 MAPK14 PIK3R1 MAP2K4 MAPK11 ITGB1 COL1A1 COL1A2 MAPK3 PIK3CA CRK RPS6KA1 PID_WNT_SIGNALING_PATHWAY%MSIGDB_C2%PID_WNT_SIGNALING_PATHWAY PID_WNT_SIGNALING_PATHWAY FZD1 FZD2 FZD5 FZD4 RYK WNT3A IGFBP4 WNT7B ATP6AP2 FZD9 KREMEN1 WNT7A FZD8 LRP5 FZD10 LRP6 WIF1 ROR2 RSPO1 WNT1 DKK1 WNT3 CTHRC1 FZD7 BIOCARTA_P35ALZHEIMERS_PATHWAY%MSIGDB_C2%BIOCARTA_P35ALZHEIMERS_PATHWAY BIOCARTA_P35ALZHEIMERS_PATHWAY CAPNS1 CAPNS2 PPP2CA CDK5 APP CDK5R1 GSK3B BIOCARTA_BARRESTIN_SRC_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_SRC_PATHWAY BIOCARTA_BARRESTIN_SRC_PATHWAY MAPK1 MAP2K2 HRAS c-fgr ADCY1 RAF1 PLCB1 MAP2K1 MAPK3 KCNA1 KCNA2 KCNA3 ADRBK1 GNAS PID_ALPHA_SYNUCLEIN_PATHWAY%MSIGDB_C2%PID_ALPHA_SYNUCLEIN_PATHWAY PID_ALPHA_SYNUCLEIN_PATHWAY HEL-S-67p PARK2 SLC6A3 UBE2L3 PLD2 MAPK1 BLK KLK6 GRK5 CSNK2A1 SNCA YES1 SYK TH HEL-117 c-fgr STUB1 BAD SRC LYN FYN MAPK3 LCK PTK2B FKBP1A PLCB2 PPP2R5D BIOCARTA_VDR_PATHWAY%MSIGDB_C2%BIOCARTA_VDR_PATHWAY BIOCARTA_VDR_PATHWAY KAT2B NCOA1 NR1i1 MED1 RXRA HDAC1 SMARCE1 PRMT1 SMARCD1 SUPT16H SMARCC1 SMARCC2 ARID1A SMARCA4 CARM1 ACTL6A BAZ1B NCOR1 CHAF1A TSC2 EP300 CREBBP BIOCARTA_PDGF_PATHWAY%MSIGDB_C2%BIOCARTA_PDGF_PATHWAY BIOCARTA_PDGF_PATHWAY GRB2 SOS1 CSNK2A1 HRAS JUN SHC1 PIK3R1 FOS MAP2K4 STAT3 MAP3K1 RAF1 STAT1 PDGFA JAK1 DKFZp434N101 PDGFRA MAP2K1 PRKCB MAPK3 PRKCA PIK3CA MAPK8 BIOCARTA_GRANULOCYTES_PATHWAY%MSIGDB_C2%BIOCARTA_GRANULOCYTES_PATHWAY BIOCARTA_GRANULOCYTES_PATHWAY CSF3 SELPLG IFNG IL8 SELP ITGAM TNF-alpha SELL PECAM1 ICAM2 IL1A PID_AMB2_NEUTROPHILS_PATHWAY%MSIGDB_C2%PID_AMB2_NEUTROPHILS_PATHWAY PID_AMB2_NEUTROPHILS_PATHWAY IL6 BLK THY1 YES1 c-fgr PRKCZ SRC CTGF RAP1A SELPLG ITGAM SELP LYN PLAT FYN HMGB1 NFKB1 APOB TLN1 JAM2 JAM3 LCK PLAUR MYH2 ARHA MMP2 PLG TNF-alpha ROCK1 MMP9 BIOCARTA_BAD_PATHWAY%MSIGDB_C2%BIOCARTA_BAD_PATHWAY BIOCARTA_BAD_PATHWAY CSF2RB IGF1 IL3 IL3RA BCL2 IGF1R KITLG MAPK1 KIT PIK3R1 BAD ADCY1 BAX PRKAR1B MAPK3 PRKAR1A PIK3CA PRKACG RPS6KA1 PID_FOXM1_PATHWAY%MSIGDB_C2%PID_FOXM1_PATHWAY PID_FOXM1_PATHWAY CCNA2 CCNE1 MYC SKP2 BRCA2 MAP2K1 CREBBP LAMA4 CDKN2A CDC2 GSK3A CDK2 ONECUT1 SP1 FOXM1 CENPA CENPB AURKB CKS1B FOS CCNB2 CCND1 MMP2 RB1 NEK2 NFATC3 H2BC1 ETV5 CENPF GAS1 EP300 CDK4 BIRC5 PLK1 DKFZp686G14213 TGFA CHEK2 CCNB1 BIOCARTA_LYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_LYMPHOCYTE_PATHWAY BIOCARTA_LYMPHOCYTE_PATHWAY SELE CD44 ITGA4 SELL PECAM1 ITGB1 BIOCARTA_ARF_PATHWAY%MSIGDB_C2%BIOCARTA_ARF_PATHWAY BIOCARTA_ARF_PATHWAY MYC RAC1 POLR1A POLR1C MDM2 POLR1D TWIST1 TBX2 PIK3R1 RB1 PIK3CA CDKN2A PID_TXA2PATHWAY%MSIGDB_C2%PID_TXA2PATHWAY PID_TXA2PATHWAY PTGDR PTGIR VCAM1 HEL-S-45 BLK RAB11A GNB1 YES1 SYK ARHGEF1 PRKCE GNB5 MAPK14 c-fgr MAPK11 PRKCZ SRC ARRB2 RAC1 LYN FYN GNA14 LCK GNA15 GNA11 PRKCH ARHA EGF GNAQ PRKCQ SELE PLCB2 ROCK1 ARR3 PRKCB PIK3R5 GNA13 SLC9A3R1 PRKCA GRK3 EGFR GNG2 ADRBK1 TBXA2R PID_ERBB4_PATHWAY%MSIGDB_C2%PID_ERBB4_PATHWAY PID_ERBB4_PATHWAY MAPK1 PIK3R3 PIK3CD PIK3R2 SHC1 PRL PIK3R1 LRIG1 WWOX CBFA2T3 PRLR DKFZp451O0517 NRG1 ADAM17 NRG2 DLG4 NEDD4 EREG BTC NCOR1 NRG3 ERBB4 NRG4 MDM2 HBEGF FYN MAPK3 PIK3CA WWP1 GRIN2B GRB2 STAT5B ERBB2 ITCH BIOCARTA_CREB_PATHWAY%MSIGDB_C2%BIOCARTA_CREB_PATHWAY BIOCARTA_CREB_PATHWAY GRB2 RPS6KA5 MAPK1 SOS1 CREB1 HRAS MAPK14 PIK3R1 ADCY1 RAC1 PRKCB PRKAR1B MAPK3 PRKAR1A PRKCA PIK3CA PRKACG RPS6KA1 PID_IL8_CXCR2_PATHWAY%MSIGDB_C2%PID_IL8_CXCR2_PATHWAY PID_IL8_CXCR2_PATHWAY PLD2 RAB11A GNB1 c-fgr ARRB2 IL8RB PPP2R1A PPP2CA VASP ELMO1 DOCK2 RAB5A RAB7A LYN GNA14 PDPK1 CBL GNA15 PLCB3 PLCB1 PLCB2 IL8 PRKCB PRKCA GNG2 BIOCARTA_LIS1_PATHWAY%MSIGDB_C2%BIOCARTA_LIS1_PATHWAY BIOCARTA_LIS1_PATHWAY LRP8 RELN CSNK2A1 CDK5 PAFAH1B1 CDK5R1 DKFZp686I0746 DCTN6 DNAH2 DNAH8 DNAH6 DCTN3 DCX DNCL1 NDEL1 BIOCARTA_EPO_PATHWAY%MSIGDB_C2%BIOCARTA_EPO_PATHWAY BIOCARTA_EPO_PATHWAY GRB2 PTPN6 STAT5B SOS1 CSNK2A1 HRAS JUN SHC1 FOS RAF1 DKFZp434N101 MAP2K1 MAPK3 EPO EPOR MAPK8 BIOCARTA_UCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_UCALPAIN_PATHWAY BIOCARTA_UCALPAIN_PATHWAY CAPNS1 EZR CAPNS2 RAC1 ACTA1 ARHA ACTN1 ITGB1 TLN1 ITGB3 BIOCARTA_ERBB4_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB4_PATHWAY BIOCARTA_ERBB4_PATHWAY PSEN1 NRG3 ERBB4 PRKCB PRKCA ADAM17 NRG2 PID_NEPHRIN_NEPH1_PATHWAY%MSIGDB_C2%PID_NEPHRIN_NEPH1_PATHWAY PID_NEPHRIN_NEPH1_PATHWAY PIK3R3 PIK3CD PIK3R2 NCK1 JUN MAPK9 PIK3R1 MAP2K4 BAD PRKCZ MAPK10 ARRB2 PARD6A RAC1 DKFZp434N101 FYN PIK3CA MAPK8 KIRREL1 GRB2 PRKCI CD2AP DKFZp686A1195 NPHS1 NCK2 TRPC6 NPHS2 F2RL2 WASL PID_CASPASE_PATHWAY%MSIGDB_C2%PID_CASPASE_PATHWAY PID_CASPASE_PATHWAY MAP3K1 CRADD TRADD hCG_20684 PRF1 TRAF2 BAX TNFRSF1A RIPK1 ACTA1 HEL113 PIDD1 BCL2 CASP10 CASP6 hCG_16983 NUMA1 DIABLO SATB1 LMNB2 CASP9 CASP3 CFL2 CASP4 LMNA ARHGDIB TFAP2A DFFB TNF-alpha DFFA PARP1 LIMK1 KRT18 APP MADD GAS2 APAF1 DKFZp666O0110 CYCS BIRC2 BIRC3 BIOCARTA_THELPER_PATHWAY%MSIGDB_C2%BIOCARTA_THELPER_PATHWAY BIOCARTA_THELPER_PATHWAY CD3E CD3D THY1 CD2 CD247 PTPRC CD3G PID_CDC42_PATHWAY%MSIGDB_C2%PID_CDC42_PATHWAY PID_CDC42_PATHWAY ARPC1B KIAA0142 ACTR3 ACTR2 MAPK1 PAX6 TIAM1 IQGAP3 YES1 PRKCE HEL-S-15 MAP2K3 HEL-S-47e HES5 MAP2K4 PAK4 TNK2 GSK3B MAP3K1 LIMK2 SRC BRAF APC ARPC4 CDC42BPA BAIAP2 ARPC2 CDC42 ARPC3 CTNNA1 hCG_1991735 MAP2K6 VAV2 RASGRF1 JUN MAPK9 MAPK14 PIK3R1 PRKCZ DKFZp686P1551 RAC1 PARD6A MTOR MAPK3 PIK3CA MYL2 RPS6KB1 MAPK8 CBL HRAS F2RL2 MAP3K11 CTNNB1 ATF2 RAF1 LIMK1 WASL PAK1 BIOCARTA_VEGF_PATHWAY%MSIGDB_C2%BIOCARTA_VEGF_PATHWAY BIOCARTA_VEGF_PATHWAY VEGFA FLT4 HRAS SHC1 PIK3R1 EIF2B5 HIF1A EIF2B3 FLT1 EIF2B2 EIF1AX DKFZp434N101 EIF2S2 PRKCB SUI1 ELAVL1 EIF2S1 PRKCA EIF2S3 PIK3CA KDR VHL EIF2B1 BIOCARTA_AKT_PATHWAY%MSIGDB_C2%BIOCARTA_AKT_PATHWAY BIOCARTA_AKT_PATHWAY FOXO1 GHR GH1 PIK3R1 IKBKB BAD FOXO3 NFKBIA RELA CHUK CASP9 PPP2CA TNFSF6 IKBKG NFKB1 PIK3CA PDPK1 FOXO4 BIOCARTA_RAB_PATHWAY%MSIGDB_C2%BIOCARTA_RAB_PATHWAY BIOCARTA_RAB_PATHWAY RAB1A RAB6C RAB4A RAB11A RAB3A RAB5A RAB2 RAB7A RAB9A ACTA1 RAB27A RAB8A BIOCARTA_CREM_PATHWAY%MSIGDB_C2%BIOCARTA_CREM_PATHWAY BIOCARTA_CREM_PATHWAY FSHR ADCY1 FSHB CREM FHL5 PID_SYNDECAN_3_PATHWAY%MSIGDB_C2%PID_SYNDECAN_3_PATHWAY PID_SYNDECAN_3_PATHWAY PSEN1 SRC PSENEN SDC3 CASK PTN POMC MC4R APH1B IL8 AgRP CSPG3 FYN EGFR PID_AURORA_A_PATHWAY%MSIGDB_C2%PID_AURORA_A_PATHWAY PID_AURORA_A_PATHWAY RAN KIAA0142 GADD45A NFKBIA GSK3B MDM2 NDEL1 CENPA AURKB AURKA DKFZp686K18126 BRCA1 PPP2R5D HCTP4 OAZ1 BIRC5 FZR1 DLGAP5 TDRD7 CKAP5 DKFZp686G14213 TACC3 AURKAIP1 PAK1 AJUBA PID_MYC_ACTIV_PATHWAY%MSIGDB_C2%PID_MYC_ACTIV_PATHWAY PID_MYC_ACTIV_PATHWAY KAT2A TAF12 TAF10 ACTL6A BAX SUPT7L E2F3 RUVBL2 RUVBL1 HTATIP CREBBP EIF2S1 NBN HEL-S-17 NCL BIRC5 DKFZp686O0451 HEL-S-133P CCNB1 EIF4A1 BMI1 PMAIP1 PEG10 PIM1 ID2 UBTF RCC1 HEL-S-162eP CAD NME2 PTMAP7 BCAT1 HMGA1 SHMT1 RPL11 IREB2 CDCA7 TERT HSPD1 CCND2 MYC MTDH PRDX3 MDIG MYCT1 PDCD10 EIF4E HSPA4 HUWE1 KIR3DL1 FOSL1 SMAD4 LIN28B GPAM POLR3D SNAI1 NDUFAF2 TAF4B SERPINI1 PFKM EIF4G1 MAX TRRAP EP300 CDK4 TK1 MMP9 BIOCARTA_HER2_PATHWAY%MSIGDB_C2%BIOCARTA_HER2_PATHWAY BIOCARTA_HER2_PATHWAY IL6 GRB2 ERBB3 MAPK1 SOS1 GRIP1 ERBB2 IL6ST HRAS IL6R SHC1 PIK3R1 STAT3 CARM1 RAF1 ERBB4 EP300 MAP2K1 MAPK3 PIK3CA EGFR BIOCARTA_PTC1_PATHWAY%MSIGDB_C2%BIOCARTA_PTC1_PATHWAY BIOCARTA_PTC1_PATHWAY CDC2 CDK7 SHH CCNH PTCH1 MNAT1 DKFZp686G14213 CCNB1 PID_TNF_PATHWAY%MSIGDB_C2%PID_TNF_PATHWAY PID_TNF_PATHWAY MAP2K3 IKBKB MAP4K2 PRKCZ MAP3K1 RELA ADAM17 CHUK TRADD SMPD1 TRAF2 TNFRSF1A RIPK1 IKBKG MAP3K7 NFKB1 HEL-S-31 PRKCI MAP3K7IP1 hCG_16983 NRK TNFAIP3 TXN SMPD2 MAP3K5 BAG4 FADD RFFL STAT1 TRAF1 TNFRSF1B CYLD TNF-alpha TNIK SQSTM1 NSMAF MADD BIRC2 BIRC3 PID_P38_MK2_PATHWAY%MSIGDB_C2%PID_P38_MK2_PATHWAY PID_P38_MK2_PATHWAY YWHAQ SFN CREB1 HEL-S-1 TH MAPK14 YWHAG MAPK11 HEL2 YWHAZ RAF1 HEL-S-102 MAPKAPK2 TSC2 MAPKAPK3 TCF3 DKFZp686G14213 BIOCARTA_BIOPEPTIDES_PATHWAY%MSIGDB_C2%BIOCARTA_BIOPEPTIDES_PATHWAY BIOCARTA_BIOPEPTIDES_PATHWAY GNA11 GRB2 MAPK1 AGTR2 SOS1 CALM2 PTK2B MAP2K2 CDK5 HRAS SHC1 MAPK14 STAT3 RAF1 STAT1 HEL-S-72 DKFZp434N101 MAP2K1 PRKCB FYN MAPK3 KNG1 PRKCA MAPK8 BIOCARTA_NOS1_PATHWAY%MSIGDB_C2%BIOCARTA_NOS1_PATHWAY BIOCARTA_NOS1_PATHWAY GRIN2B CALM2 HEL-S-72 PRKAR1B PRKCB PRKAR1A PRKACG PRKCA GRIN1 PPP3CA DLG4 PPP3CC BIOCARTA_TCYTOTOXIC_PATHWAY%MSIGDB_C2%BIOCARTA_TCYTOTOXIC_PATHWAY BIOCARTA_TCYTOTOXIC_PATHWAY CD3E CD3D THY1 CD2 CD247 CD8A PTPRC CD3G PID_GLYPICAN_1PATHWAY%MSIGDB_C2%PID_GLYPICAN_1PATHWAY PID_GLYPICAN_1PATHWAY PLA2G2A VEGFA GPC1 TGFBR1 SLIT2 FGFR1 TGFBR2 TDGF1 BLK YES1 c-fgr SRC NRG1 LAMA1 FLT1 FGF2 LYN SMAD2 APP FYN TGFB1 PRNP LCK SERPINC1 BIOCARTA_NGF_PATHWAY%MSIGDB_C2%BIOCARTA_NGF_PATHWAY BIOCARTA_NGF_PATHWAY GRB2 SOS1 NGFR CSNK2A1 NGF DPM2 HRAS JUN SHC1 PIK3R1 FOS RAF1 DKFZp434N101 MAP2K1 MAPK3 PIK3CA MAPK8 PID_CXCR3_PATHWAY%MSIGDB_C2%PID_CXCR3_PATHWAY PID_CXCR3_PATHWAY NRAS CCL11 MAPK1 PIK3R3 GNB1 PIK3CD CXCL9 PIK3R2 MAPKAP1 MAP2K3 MAPK14 PIK3R1 CXCL13 CXCR3 MAPK11 MLST8 KRAS RICTOR SRC CXCL10 CXCL11 PF4 MAP2K6 MAP2K1 MTOR MAPK3 GNAZ GNAI3 PIK3CA GNAI1 PDPK1 MAP2K2 HRAS GNAO1 RAF1 GNG2 BIOCARTA_TRKA_PATHWAY%MSIGDB_C2%BIOCARTA_TRKA_PATHWAY BIOCARTA_TRKA_PATHWAY NTRK1 GRB2 SOS1 NGF DPM2 HRAS DKFZp434N101 SHC1 PRKCB PIK3R1 PIK3CA PRKCA PID_VEGFR1_PATHWAY%MSIGDB_C2%PID_VEGFR1_PATHWAY PID_VEGFR1_PATHWAY CBL VEGFA MAPK1 CD2AP NCK1 PIK3R1 NRP1 SHC2 VEGFB HIF1A DKFZp686J1169 FLT1 PTPN11 DKFZp434N101 PRKCB MAPK3 PRKCA PIK3CA PDPK1 BIOCARTA_PLK3_PATHWAY%MSIGDB_C2%BIOCARTA_PLK3_PATHWAY BIOCARTA_PLK3_PATHWAY PLK3 ATM ATR CHEK1 CHEK2 BIOCARTA_VIP_PATHWAY%MSIGDB_C2%BIOCARTA_VIP_PATHWAY BIOCARTA_VIP_PATHWAY CALM2 EGR2 NFKBIA MAP3K1 RELA CHUK GNAQ MYC VIPR2 VIP HEL-S-72 DKFZp434N101 PRKAR1B NFATC2 NFATC1 NFKB1 PRKAR1A PRKACG PPP3CA PPP3CC PID_GMCSF_PATHWAY%MSIGDB_C2%PID_GMCSF_PATHWAY PID_GMCSF_PATHWAY CSF2RB NRAS MAPK1 PIM1 SYK SHC1 PIK3R1 IKBKB STAT3 KRAS CSF2 LYN PTPN11 CSF2RA GAB2 CCL2 MAP2K1 MAPK3 CISH OSM PRKACG PIK3CA IRF8 GRB2 STAT5B SOS1 MAP2K2 HRAS FOS YWHAZ RAF1 STAT1 BIOCARTA_BARRESTIN_PATHWAY%MSIGDB_C2%BIOCARTA_BARRESTIN_PATHWAY BIOCARTA_BARRESTIN_PATHWAY PLCB1 ADCY1 KCNA1 KCNA2 KCNA3 NR1C1 ADRBK1 AP2A1 GNAS AP2M1 BIOCARTA_CARDIACEGF_PATHWAY%MSIGDB_C2%BIOCARTA_CARDIACEGF_PATHWAY BIOCARTA_CARDIACEGF_PATHWAY EDNRA ADAM12 AGTR2 EDNRB HRAS JUN EDN1 FOS ARHA EGF RELA MYC DKFZp434N101 PRKCB NFKB1 PRKCA EGFR PID_WNT_NONCANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_NONCANONICAL_PATHWAY PID_WNT_NONCANONICAL_PATHWAY YES1 MAPK9 PPARG PRKCZ CAMK2A MAPK10 ARRB2 CDC42 RAC1 MAP3K7 MAPK8 NLK DKFZp586M1622 DVL1 DVL2 FLNA SETDB1 FZD2 CSNK1A1 MAP3K7IP1 FZD5 DAAM1 ARHA ROR2 ROCK1 CTHRC1 NFATC2 FZD7 BIOCARTA_IL12_PATHWAY%MSIGDB_C2%BIOCARTA_IL12_PATHWAY BIOCARTA_IL12_PATHWAY IFNG JUN TYK2 MAPK14 STAT4 CXCR3 IL12RB1 CCR5 IL18R1 CD3G ETV5 CD3E CD3D MAP2K6 CD247 IL18 MAPK8 BIOCARTA_P27_PATHWAY%MSIGDB_C2%BIOCARTA_P27_PATHWAY BIOCARTA_P27_PATHWAY TFDP1 CDK2 SKP2 CCNE1 CKS1B RBX1 RB1 NEDD8 CDKN1B UBE2M SKP1 BIOCARTA_RELA_PATHWAY%MSIGDB_C2%BIOCARTA_RELA_PATHWAY BIOCARTA_RELA_PATHWAY IKBKB NFKBIA TRAF6 RELA CHUK TRADD FADD TNFRSF1B TNFRSF1A RIPK1 TNF-alpha IKBKG EP300 CREBBP NFKB1 PID_ARF6_PATHWAY%MSIGDB_C2%PID_ARF6_PATHWAY PID_ARF6_PATHWAY ADRB2 NCK1 TSHR ACAP1 SRC ITGB3 AGTR1 ARRB2 ARF6 GNA14 GNA15 GNA11 EGF GNAQ MST051 ITGA2B CYTH3 CYTH2 KIF13B HGF LHCGR USP6 ARAP2 PXN IPCEF1 GULP1 EFNA1 ACAP2 EPHA2 EGFR PID_RXR_VDR_PATHWAY%MSIGDB_C2%PID_RXR_VDR_PATHWAY PID_RXR_VDR_PATHWAY NR1H4 NR1H3 RXRB BCL2 NR1C2 NR1B3 NCOA1 NR1i1 NCOR2 MED1 FAM120B RXRA RARA RARB RXRG PPARG TNF-alpha ABCA1 TGFB1 THRB NR1C1 RPS6KB1 THRA NR1H2 PID_NFKAPPAB_CANONICAL_PATHWAY%MSIGDB_C2%PID_NFKAPPAB_CANONICAL_PATHWAY PID_NFKAPPAB_CANONICAL_PATHWAY RAN ATM RIPK2 UBE2D3 IKBKB NOD2 NFKBIA BCL10 TRAF6 ERC1 TNFAIP3 RELA CHUK TNFRSF1A CYLD TNF-alpha IKBKG NFKB1 PRKCA BIRC2 PID_IL1_PATHWAY%MSIGDB_C2%PID_IL1_PATHWAY PID_IL1_PATHWAY JUN PIK3R1 IKBKB PRKCZ ERC1 TRAF6 HEL-S-71 RELA IL1RN CHUK IRAK1 TICAM2 IL1R1 IL1R2 IRAK3 IRAK4 IL1B IKBKG MAP3K7 UBE2V1 MAP2K6 MYD88 NFKB1 PIK3CA MAPK8 PRKCI MAP3K7IP1 IL1A SQSTM1 BIOCARTA_GCR_PATHWAY%MSIGDB_C2%BIOCARTA_GCR_PATHWAY BIOCARTA_GCR_PATHWAY ADRB2 NR3C1 CALM2 HEL-S-72 ANXA1 NPPA PIK3R1 CORIN NFKB1 PIK3CA RELA GNAS PID_RHOA_REG_PATHWAY%MSIGDB_C2%PID_RHOA_REG_PATHWAY PID_RHOA_REG_PATHWAY ARHGEF1 HEL-S-47e VAV2 ARHGAP9 TRIO ARHGAP8 ARHGEF25 ARHGEF28 ARHGDIG ARHGEF10L ARHGAP5 ARHGAP35 ARHGAP4 OPHN1 MCF2L ECT2 SRGAP1 ARHGEF2 ARHGEF11 ARHA VAV3 FARP1 ARHGEF10 ARHGEF12 CDKN1B ARHGEF15 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B ARHGDIB ARAP1 DEF6 VAV1 NET1 BCR OBSCN ARHGEF3 ARHGEF5 BIOCARTA_CFTR_PATHWAY%MSIGDB_C2%BIOCARTA_CFTR_PATHWAY BIOCARTA_CFTR_PATHWAY ADRB2 EZR PRKAR1B ADCY1 PRKAR1A CFTR SLC9A3R1 PRKACG BIOCARTA_SAM68_PATHWAY%MSIGDB_C2%BIOCARTA_SAM68_PATHWAY BIOCARTA_SAM68_PATHWAY CDC2 MAPK1 HRAS MAPK3 KHDRBS1 PID_LIS1_PATHWAY%MSIGDB_C2%PID_LIS1_PATHWAY PID_LIS1_PATHWAY NUDC HEL-S-303 DYNLT1 PAFAH1B3 CDK5R2 CSNK2A1 HEL2 CDC42 RAC1 hCG_1991735 DCX LRPAP1 NDEL1 VLDLR LRP8 DAB1 RELN CDK5 MAP1B ARHA PAFAH1B1 CDK5R1 PPP2R5D PLA2G7 KATNA1 DYNC1H1 PID_AVB3_OPN_PATHWAY%MSIGDB_C2%PID_AVB3_OPN_PATHWAY PID_AVB3_OPN_PATHWAY MAPK1 ROCK2 PIP5K1A SYK JUN HEL-S-28 PIK3R1 NFKBIA MAP3K1 RELA ITGB3 CHUK DKFZp686J04131 CDC42 RAC1 ITGAV MAPK3 NFKB1 PIK3CA MAPK8 PTK2B FOS ARHA VAV3 MMP2 opn CD44 MMP9 PID_ECADHERIN_KERATINOCYTE_PATHWAY%MSIGDB_C2%PID_ECADHERIN_KERATINOCYTE_PATHWAY PID_ECADHERIN_KERATINOCYTE_PATHWAY PIP5K1A CASR FMN1 PIK3R1 ARHA ZYX CTNNB1 SRC VASP RAC1 CTNNA1 DKFZp434N101 FYN JUP PIK3CA CTNND1 EGFR AJUBA PID_DELTA_NP63_PATHWAY%MSIGDB_C2%PID_DELTA_NP63_PATHWAY PID_DELTA_NP63_PATHWAY SFN NR1i1 TOP2A GSK3B NOTCH1 STXBP4 DKFZp451O0517 NRG1 RRAD FBXW7 DLX5 DLX6 TBXT PPP2R5A HELLS GPX2 TCF7L1 ADRM1 MDM2 KRT5 BRCA2 POU2F2 FOSL2 RUNX1 AXL HES1 FASN KRT14 RAB38 CEBPD CDKN2A ADA WWP1 BDKRB2 ATM ITCH MRE11A CCNB2 IL1A TP63 PERP BIOCARTA_RACCYCD_PATHWAY%MSIGDB_C2%BIOCARTA_RACCYCD_PATHWAY BIOCARTA_RACCYCD_PATHWAY MAPK1 TFDP1 CDK2 HRAS CCNE1 PIK3R1 IKBKB ARHA NFKBIA CCND1 RB1 CDKN1A RELA CDKN1B CHUK RAF1 CDK6 RAC1 IKBKG CDK4 MAPK3 NFKB1 PIK3CA PAK1 BIOCARTA_NKT_PATHWAY%MSIGDB_C2%BIOCARTA_NKT_PATHWAY BIOCARTA_NKT_PATHWAY IFNGR1 IL4 IFNGR2 CCL4 IL5 CCL3 CCR7 IFNG CCR4 CCR3 CXCR3 IL12RB1 CCR5 IL18R1 CD40LG CXCR4 CSF2 IL2 TGFB1 CCR1 PID_IFNG_PATHWAY%MSIGDB_C2%PID_IFNG_PATHWAY PID_IFNG_PATHWAY MAPK1 IFNG SOCS1 PIK3R1 STAT3 MAP3K1 CAMK2A RAP1A JAK1 IL1B PTPN11 CAMK2G MAP2K1 MTOR MAPK3 CREBBP CEBPB RAPGEF1 CRKL PIK3CA CBL IFNGR1 CAMK2D PIAS1 IRF1 MAP3K11 IRF9 STAT1 EP300 PID_INTEGRIN2_PATHWAY%MSIGDB_C2%PID_INTEGRIN2_PATHWAY PID_INTEGRIN2_PATHWAY VCAM1 THY1 FGA SPON2 F10 HEL-S-62p CD40LG ICAM3 ICAM4 F11R GP1BA HEL-S-78p FCGR2A PROC ITGAX ITGAM TGFBI ICAM2 PLAT KNG1 JAM3 PLAUR BIOCARTA_NPP1_PATHWAY%MSIGDB_C2%BIOCARTA_NPP1_PATHWAY BIOCARTA_NPP1_PATHWAY COL4A6 COL4A5 IBSP ALPL ENPP1 COL4A2 opn COL4A1 COL4A4 COL4A3 BIOCARTA_P53_PATHWAY%MSIGDB_C2%BIOCARTA_P53_PATHWAY BIOCARTA_P53_PATHWAY BCL2 CDK2 ATM CCNE1 GADD45A CCND1 RB1 CDKN1A BAX PCNA MDM2 CDK4 TIMP3 APAF1 BIOCARTA_IL4_PATHWAY%MSIGDB_C2%BIOCARTA_IL4_PATHWAY BIOCARTA_IL4_PATHWAY IL4 GRB2 JAK3 JAK1 IRS1 STAT6 SHC1 IL2RG RPS6KB1 BIOCARTA_IRES_PATHWAY%MSIGDB_C2%BIOCARTA_IRES_PATHWAY BIOCARTA_IRES_PATHWAY EIF4A1 EIF4G1 EIF3A EIF4E EIF4A2 AAG1 BIOCARTA_FEEDER_PATHWAY%MSIGDB_C2%BIOCARTA_FEEDER_PATHWAY BIOCARTA_FEEDER_PATHWAY LCT HEL-S-49 TREH PYGM PYGL BIOCARTA_RANKL_PATHWAY%MSIGDB_C2%BIOCARTA_RANKL_PATHWAY BIOCARTA_RANKL_PATHWAY IFNAR2 EIF2AK2 TNFRSF11A TNFSF11 IFNAR1 FOS IRF9 TRAF6 RELA FOSL2 FOSL1 NFKB1 IFNB1 MAPK8 BIOCARTA_DSP_PATHWAY%MSIGDB_C2%BIOCARTA_DSP_PATHWAY BIOCARTA_DSP_PATHWAY DUSP4 DUSP8 DUSP2 MAPK14 DUSP9 MAPK3 MAPK8 BIOCARTA_DC_PATHWAY%MSIGDB_C2%BIOCARTA_DC_PATHWAY BIOCARTA_DC_PATHWAY IL4 IL3 IL5 IFNG CD40 CD5 CD7 TLR7 CD33 CD2 ITGAX CSF2 IL10 IFNA1 IFNB1 IL13 PID_CONE_PATHWAY%MSIGDB_C2%PID_CONE_PATHWAY PID_CONE_PATHWAY CNGA3 LRAT GNB5 SLC24A2 GUCY2D PDE6H DKFZp686E1183 GUCA1C GUCY2F RPE65 GRK1 GNGT2 RDH12 ARR3 GNAT2 RGS9BP GRK7 PDE6C RDH5 CNGB3 GNB3 BIOCARTA_WNT_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_PATHWAY BIOCARTA_WNT_PATHWAY AXIN1 NLK CTBP1 NR1C2 DVL1 DKFZp781N011 FRAT1 FZD1 CSNK2A1 MAP3K7IP1 HDAC1 CCND1 CTNNB1 GSK3B HNF1A APC MYC PPP2CA WIF1 MAP3K7 WNT1 CREBBP SMAD4 PID_THROMBIN_PAR1_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR1_PATHWAY PID_THROMBIN_PAR1_PATHWAY ROCK2 GNB1 ARHGEF1 HEL-S-47e PIK3R1 ZYX VASP GNAZ GNAI3 PIK3CA GNAI1 MYL2 GNA14 GNA15 GNA11 SNX1 SNX2 TRPC6 F2R PKN1 F2RL2 GNAO1 ARHA PLCB3 GNAQ PLCB1 PLCB2 ROCK1 PRKCB GNA13 PRKCA GRK3 GNG2 BIOCARTA_CHREBP_PATHWAY%MSIGDB_C2%BIOCARTA_CHREBP_PATHWAY BIOCARTA_CHREBP_PATHWAY PRKAA1 PRKAB2 ADCY1 PRKAA2 PRKAG2 PRKAG3 MLXIPL PPP2CA PRKAG1 PRKAB1 PRKAR1B PRKAR1A PRKACG GNAS BIOCARTA_ASBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_ASBCELL_PATHWAY BIOCARTA_ASBCELL_PATHWAY IL4 HLA-DRB4 CD80 HLA-DRA HLA-DRB3 TNFSF6 HLA-DRB1 IL10 CD40 IL2 CD40LG HLA-DRB5 PID_MET_PATHWAY%MSIGDB_C2%PID_MET_PATHWAY PID_MET_PATHWAY RANBP9 RANBP10 MUC20 MAPK1 NCK1 MAP2K4 PAK4 MLST8 MAP3K1 SRC APC CDC42 RAP1A CTNNA1 RAPGEF1 CRK HGF JUN SHC1 PIK3R1 BAD PRKCZ RAC1 PARD6A RAB5A EIF4E PTPN11 DKFZp434N101 GAB2 ARF6 MAP2K1 MTOR MAPK3 PTPN1 CRKL PIK3CA SNAI1 PDPK1 MAPK8 CBL GRB2 PRKCI SOS1 MAP2K2 HRAS NCK2 F2RL2 ARHA CTNNB1 RAF1 raptor INPPL1 DKFZp434G2016 DEPTOR PXN HGS WASL AKT1S1 NUMB RIN2 DKFZp666O0110 DKFZp686B23205 EIF4EBP1 PAK1 EGR1 BIOCARTA_NPC_PATHWAY%MSIGDB_C2%BIOCARTA_NPC_PATHWAY BIOCARTA_NPC_PATHWAY RAN RANBP2 NUP214 NUP210 hCG_19665 RCC1 NUTF2 NUP153 KPNA2 PID_PI3KCI_AKT_PATHWAY%MSIGDB_C2%PID_PI3KCI_AKT_PATHWAY PID_PI3KCI_AKT_PATHWAY SLC2A4 SFN MAPKAP1 FOXO3 AKT3 BAD HEL2 MLST8 TBC1D4 GSK3B RICTOR SRC CHUK MTOR FOXO4 PDPK1 FOXO1 YWHAQ GSK3A HEL-S-1 BCL2L1 YWHAG CDKN1A YWHAZ CDKN1B CASP9 MAP3K5 RAF1 PRKDC BIOCARTA_TSP1_PATHWAY%MSIGDB_C2%BIOCARTA_TSP1_PATHWAY BIOCARTA_TSP1_PATHWAY THBS1 JUN MAPK14 FOS FYN CD36 CASP3 BIOCARTA_EGF_PATHWAY%MSIGDB_C2%BIOCARTA_EGF_PATHWAY BIOCARTA_EGF_PATHWAY GRB2 SOS1 CSNK2A1 HRAS JUN SHC1 PIK3R1 FOS MAP2K4 EGF STAT3 MAP3K1 RAF1 STAT1 JAK1 DKFZp434N101 MAP2K1 PRKCB MAPK3 PRKCA PIK3CA EGFR MAPK8 BIOCARTA_RNAPOL3_PATHWAY%MSIGDB_C2%BIOCARTA_RNAPOL3_PATHWAY BIOCARTA_RNAPOL3_PATHWAY SSB TBP GTF3C5 GTF3C1 GTF3C3 HEL-S-76p PID_AR_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_AR_NONGENOMIC_PATHWAY PID_AR_NONGENOMIC_PATHWAY MAPK1 CREB1 GNB1 PIK3R1 SRC CDC42 PLCG2 RAC1 PELP1 GNRH1 SHBG DKFZp434N101 MAP2K1 MAPK3 GNAZ GNAI3 PIK3CA GNAI1 MAP2K2 HRAS FOS GNAO1 PLCB3 RAF1 PLCB1 PLCB2 DKFZp666O0110 GNG2 PID_AR_TF_PATHWAY%MSIGDB_C2%PID_AR_TF_PATHWAY PID_AR_TF_PATHWAY KAT2B NCOA1 RXRA JUN MAPK14 SMARCE1 MAP2K4 GSK3B REL CEBPA SRC SMARCC1 CARM1 MDM2 TMPRSS2 MAP2K6 HTATIP KLK3 NR2C2 HOXB13 CREBBP ZMIZ2 TRIM24 KAT7 SRY MAPK8 SPDEF NR3C1 FOXO1 DKFZp686P15142 RXRB POU2F1 NR0B1 APPBP2 PDE9A RXRG HDAC1 PKN1 GATA2 HDAC7 EP300 RCHY1 SIRT1 EGR1 PID_THROMBIN_PAR4_PATHWAY%MSIGDB_C2%PID_THROMBIN_PAR4_PATHWAY PID_THROMBIN_PAR4_PATHWAY GNA15 GNA11 ROCK2 GNB1 F2RL3 F2RL2 ARHA GNAQ PLCB2 ROCK1 GNA13 MYL2 GNA14 GNG2 BIOCARTA_MTA3_PATHWAY%MSIGDB_C2%BIOCARTA_MTA3_PATHWAY BIOCARTA_MTA3_PATHWAY MBD3 GREB1 HEL-S-162eP HDAC1 PDZK1 TUBA4A TUBA1A HEL-S-130P TUBA2 MTA3 HSPB2-C11orf52 HEL-S-87p HEL-S-102 SNAI2 SNAI1 BIOCARTA_MONOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MONOCYTE_PATHWAY BIOCARTA_MONOCYTE_PATHWAY SELE CD44 ITGA4 SELP ITGAM SELL PECAM1 ITGB1 BIOCARTA_INTEGRIN_PATHWAY%MSIGDB_C2%BIOCARTA_INTEGRIN_PATHWAY BIOCARTA_INTEGRIN_PATHWAY CAPNS1 CAPNS2 MAPK1 JUN SHC1 ZYX RAP1A ACTA1 MAP2K1 FYN MAPK3 RAPGEF1 CRKL TLN1 MAPK8 GRB2 SOS1 MAP2K2 HRAS ARHA ITGB1 HEL114 CSK TNS1 PPP1R12B RAF1 ROCK1 BCR ACTN1 BIOCARTA_ARENRF2_PATHWAY%MSIGDB_C2%BIOCARTA_ARENRF2_PATHWAY BIOCARTA_ARENRF2_PATHWAY MAPK1 CREB1 JUN MAPK14 FOS HEL-S-166mP KEAP1 CRYZ POR FXYD2 MAFF HMOX1 MAFK hCG_1991559 PRKCB NFE2L2 PRKCA MAPK8 BIOCARTA_CSK_PATHWAY%MSIGDB_C2%BIOCARTA_CSK_PATHWAY BIOCARTA_CSK_PATHWAY ADCY1 CSK HLA-DRB5 CD3G HLA-DRB4 CD3E CD3D HLA-DRA HLA-DRB3 HLA-DRB1 CD247 PRKAR1B CREBBP ZAP70 PRKAR1A PRKACG LCK PTPRC BIOCARTA_PAR1_PATHWAY%MSIGDB_C2%BIOCARTA_PAR1_PATHWAY BIOCARTA_PAR1_PATHWAY PTK2B F2RL3 ARHGEF1 F2R PIK3R1 ARHA ADCY1 GNAQ PPP1R12B PLCB1 MAP3K7 ROCK1 PRKCB GNA13 PRKCA PIK3CA BIOCARTA_FXR_PATHWAY%MSIGDB_C2%BIOCARTA_FXR_PATHWAY BIOCARTA_FXR_PATHWAY NR1H4 NR1H3 RXRA FABP6 ABCA1 NR0B2 LDLR PID_ATM_PATHWAY%MSIGDB_C2%PID_ATM_PATHWAY PID_ATM_PATHWAY RNF8 SMC3 TP53BP1 RAP80 SMC1A TERF2 HEL-S-71 RFWD2 RBBP8 H2AX BLM MDM2 HTATIP NBN CTBP1 HEL-S-1 ATM MRE11A RAD50 FANCD2 BRCA1 RAD17 RAD9A TRIM28 MDC1 CHEK2 ABRAXAS1 BIOCARTA_SUMO_PATHWAY%MSIGDB_C2%BIOCARTA_SUMO_PATHWAY BIOCARTA_SUMO_PATHWAY UBE2I SUMO1 SUMO3 SUMO2 UBA2 SAE1 BIOCARTA_ETS_PATHWAY%MSIGDB_C2%BIOCARTA_ETS_PATHWAY BIOCARTA_ETS_PATHWAY NCOR2 RBL1 HRAS JUN FOS HDAC5 CSF1R CSF1 ETV3 ETS2 SIN3B SIN3A E2F4 HDAC2 BIOCARTA_DICER_PATHWAY%MSIGDB_C2%BIOCARTA_DICER_PATHWAY BIOCARTA_DICER_PATHWAY AGO4 AGO1 AGO2 DICER1 PID_INSULIN_GLUCOSE_PATHWAY%MSIGDB_C2%PID_INSULIN_GLUCOSE_PATHWAY PID_INSULIN_GLUCOSE_PATHWAY SLC2A4 INS YWHAQ PRKCI SFN HEL-S-1 YWHAG HEL2 TBC1D4 GSK3B PRKCZ STXBP4 YWHAZ PPP1CC HEL-S-42 INSR ASIP PPP1R3A LNPEP GYS1 TRIP10 STX4A VAMP2 BIOCARTA_CTLA4_PATHWAY%MSIGDB_C2%BIOCARTA_CTLA4_PATHWAY BIOCARTA_CTLA4_PATHWAY ITK CTLA4 GRB2 ICOS PIK3R1 HLA-DRB5 CD3G HLA-DRB4 CD3E CD80 CD3D HLA-DRA HLA-DRB3 HLA-DRB1 PTPN11 CD247 IL2 PIK3CA LCK BIOCARTA_RECK_PATHWAY%MSIGDB_C2%BIOCARTA_RECK_PATHWAY BIOCARTA_RECK_PATHWAY MMP14 TIMP1 RECK HRAS TIMP4 TIMP3 MMP2 MMP9 PID_SMAD2_3PATHWAY%MSIGDB_C2%PID_SMAD2_3PATHWAY PID_SMAD2_3PATHWAY MAPK1 NUP214 UBE2I CTDSP1 CTDSP2 NUP153 CTDSPL KPNA2 SMAD2 MAPK3 SMAD4 MAP3K1 PID_ALK2_PATHWAY%MSIGDB_C2%PID_ALK2_PATHWAY PID_ALK2_PATHWAY SMAD9 AMH BMP7 FKBP1A ACVR1 SMAD1 SMAD4 BMPR2 AMHR2 TLX2 DKFZp781O1323 BIOCARTA_ALK_PATHWAY%MSIGDB_C2%BIOCARTA_ALK_PATHWAY BIOCARTA_ALK_PATHWAY GSK3B APC MAP3K7 NPPA SMAD4 TGFB1 MYL2 AXIN1 DVL1 TGFBR1 TGFBR2 FZD1 TGFBR3 ACVR1 SMAD1 CTNNB1 ATF2 BMPR2 HNF1A DKFZp781O1323 BMP7 BMP10 GATA4 NPPB NKX2-5 WNT1 MEF2C RFC1 NOG SMAD6 BMP5 BMP4 BMP2 BMPR1A BIOCARTA_HDAC_PATHWAY%MSIGDB_C2%BIOCARTA_HDAC_PATHWAY BIOCARTA_HDAC_PATHWAY MYOD1 IGF1 CAMK1 IGF1R AVP CALM2 CAMK1G MAPK14 PIK3R1 HDAC5 MAP2K6 HEL-S-72 INSR NFATC2 NFATC1 PIK3CA CABIN1 PPP3CA MAPK7 PPP3CC BIOCARTA_PML_PATHWAY%MSIGDB_C2%BIOCARTA_PML_PATHWAY BIOCARTA_PML_PATHWAY FLJ00340 PAX3 PRAM1 RARA HRAS SUMO1 PML RB1 TNFRSF1B TNFRSF1A TNFSF6 TNF-alpha CREBBP SIRT1 PID_PI3KCI_PATHWAY%MSIGDB_C2%PID_PI3KCI_PATHWAY PID_PI3KCI_PATHWAY NRAS BLK PIK3R3 PIK3CD YES1 SYK ARF1 PIK3R2 DAPP1 PIK3R1 BLNK c-fgr FOXO3 PLEKHA1 PLEKHA2 KRAS BTK SRC SGK1 ARF5 LAT RAP1A PLCG2 RAC1 LYN DKFZp434N101 ARF6 FYN PIK3CA PTEN LCK PDPK1 ITK HRAS ARHA CYTH3 CYTH2 INPPL1 PIK3R5 ZAP70 BIOCARTA_EIF4_PATHWAY%MSIGDB_C2%BIOCARTA_EIF4_PATHWAY BIOCARTA_EIF4_PATHWAY GHR EIF4A1 MAPK1 EIF4G1 MAPK14 PIK3R1 MKNK1 PABPC1 PDK2 EIF4E IRS1 PRKCB MTOR MAPK3 EIF4A2 PRKCA AAG1 PIK3CA PTEN RPS6KB1 EIF4EBP1 PDPK1 BIOCARTA_KREB_PATHWAY%MSIGDB_C2%BIOCARTA_KREB_PATHWAY BIOCARTA_KREB_PATHWAY CS DKFZp564P2062 FH HEL-S-32 OGDH ACO2 SDHA PID_TAP63_PATHWAY%MSIGDB_C2%PID_TAP63_PATHWAY PID_TAP63_PATHWAY PMAIP1 NR1i1 GDF15 IKBKB GADD45A EGR2 PML CHUK TP53I3 BAX GPX2 MDM2 DICER1 SMARCD3 OGG1 CABL1 NOC2L ITGB4 EVPL CLCA2 CDKN2A ADA FLOT2 BBC3 NQO1 TFAP2C WWP1 YWHAQ DST AEN SSRP1 DHRS3 TRAF4 SP1 ITCH SHH CDKN1A SERPINB5 FDXR TP63 S100A2 EP300 PLK1 PERP BIOCARTA_EFP_PATHWAY%MSIGDB_C2%BIOCARTA_EFP_PATHWAY BIOCARTA_EFP_PATHWAY CDC2 SFN CDK5 CDK2 CDK8 CDK7 CDK3 TRIM25 CCNB2 CDK6 CDK4 SMURF2 SMURF1 CCNB1 BIOCARTA_BOTULIN_PATHWAY%MSIGDB_C2%BIOCARTA_BOTULIN_PATHWAY BIOCARTA_BOTULIN_PATHWAY CHRNA1 SNAP25 CHRM1 STX1A VAMP2 PID_PLK1_PATHWAY%MSIGDB_C2%PID_PLK1_PATHWAY PID_PLK1_PATHWAY NUDC ROCK2 PPP2R1A PPP2CA CDC2 RAB1A ECT2 ARHA AURKA ERCC6L BUB1B SGOL1 seTCTP CDC14B GOLGA2 KNTC2 CDC20 HEL-S-80p FBXO5 CLSPN NINL INCENP HCTP4 CENPU C13orf34 FZR1 PLK1 TUBG1 KIF20A CENPE WEE1 PRC1 GORASP1 DKFZp686G14213 KIZ DKFZp686I05169 PAK1 CCNB1 PID_RB_1PATHWAY%MSIGDB_C2%PID_RB_1PATHWAY PID_RB_1PATHWAY CCNA2 MYOD1 PAX3 TFDP1 CCNE1 MAPK11 CEBPA RBBP4 TBP E2F2 E2F3 E2F4 SKP2 CSF2 CREBBP CEBPB CEBPD CDKN2A DKFZp686H0575 CDK2 CCND1 SPI1 SUV39H1 AATF BRD2 SFTPD RUNX2 RBP2 UBTF ATF7 HDAC3 BGLAP JUN PPARG MAPK9 MITF-C MAPK14 GSC CBX4 PPP2R3B TAF1 SMARCA4 CCND2 PPP2CA CDK6 MDM2 CTBP1 HDAC1 RB1 ATF2 CDKN1A CDKN1B RAF1 CCND3 EP300 MEF2C CDK4 SIRT1 BIOCARTA_CDC25_PATHWAY%MSIGDB_C2%BIOCARTA_CDC25_PATHWAY BIOCARTA_CDC25_PATHWAY CDC2 ATM CHEK1 MYT1 WEE1 DKFZp686G14213 PID_PI3K_PLC_TRK_PATHWAY%MSIGDB_C2%PID_PI3K_PLC_TRK_PATHWAY PID_PI3K_PLC_TRK_PATHWAY NRAS SFN CREB1 NGF SHC1 PIK3R1 FOXO3 BAD HEL2 KRAS GSK3B SRC AGAP2 CAMK2A TRPC3 TRPV1 NTRK1 CAMK4 DKFZp434N101 PIK3CA PDPK1 YWHAQ GRB2 SOS1 HEL-S-1 HRAS YWHAG CCND1 YWHAZ EGR1 BIOCARTA_PGC1A_PATHWAY%MSIGDB_C2%BIOCARTA_PGC1A_PATHWAY BIOCARTA_PGC1A_PATHWAY ESRRA CAMK1 SLC2A4 CALM2 CAMK1G CAMK4 HEL-S-72 PPARGC1A HDAC5 NR1C1 PPP3CA PPP3CC BIOCARTA_CDC42RAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDC42RAC_PATHWAY BIOCARTA_CDC42RAC_PATHWAY CDC42 RAC1 PDGFRA ARHA PIK3R1 WASL PIK3CA PAK1 PID_IGF1_PATHWAY%MSIGDB_C2%PID_IGF1_PATHWAY PID_IGF1_PATHWAY IGF1R GRB2 SOS1 HRAS NCK2 SHC1 PIK3R1 BAD HEL2 PRKCZ YWHAZ RAF1 GRB10 PRKD1 IRS1 PTPN11 PXN PTPN1 DKFZp666O0110 CRKL PIK3CA RPS6KB1 CRK PDPK1 BIOCARTA_CTL_PATHWAY%MSIGDB_C2%BIOCARTA_CTL_PATHWAY BIOCARTA_CTL_PATHWAY PRF1 CD3E CD3D HLA-A TNFSF6 B2M CD247 CD3G BIOCARTA_ETC_PATHWAY%MSIGDB_C2%BIOCARTA_ETC_PATHWAY BIOCARTA_ETC_PATHWAY ZNF183 GPD2 UQCRC1 SDHC SDHA SDHD SLC25A4 HEL-S-123m SDHB SLC25A6 BIOCARTA_ERK_PATHWAY%MSIGDB_C2%BIOCARTA_ERK_PATHWAY BIOCARTA_ERK_PATHWAY IGF1R GRB2 RPS6KA5 MAPK1 SOS1 NGFR MAP2K2 NGF DPM2 HRAS SHC1 STAT3 ITGB1 MKNK1 RAF1 MYC PPP2CA PDGFRA MAP2K1 MAPK3 DKFZp686K0257 EGFR RPS6KA1 GNAS BIOCARTA_SARS_PATHWAY%MSIGDB_C2%BIOCARTA_SARS_PATHWAY BIOCARTA_SARS_PATHWAY GPT EIF4E NCL MAPK14 FBL PID_RETINOIC_ACID_PATHWAY%MSIGDB_C2%PID_RETINOIC_ACID_PATHWAY PID_RETINOIC_ACID_PATHWAY CDC2 RXRB RBP1 KAT2B NR1B3 MAPK1 NCOA1 NR1i1 NCOR2 HDAC3 RXRA RARA CDK7 RARB RXRG HDAC1 MAPK14 CCNH MNAT1 EP300 CREBBP MAPK3 PRKCA MAPK8 BIOCARTA_CALCINEURIN_PATHWAY%MSIGDB_C2%BIOCARTA_CALCINEURIN_PATHWAY BIOCARTA_CALCINEURIN_PATHWAY MARCKS CALM2 SP1 SP3 CDKN1A NFATC3 NFATC4 GNAQ HEL-S-72 DKFZp434N101 PRKCB NFATC2 NFATC1 PRKCA PPP3CA PPP3CC BIOCARTA_EICOSANOID_PATHWAY%MSIGDB_C2%BIOCARTA_EICOSANOID_PATHWAY BIOCARTA_EICOSANOID_PATHWAY PTGIR CYP2J2 KPG_011 PTGER4 PTGFR PTGIS EPHX2 PTGER2 PTGER3 EPHX1 PTGS2 PTGS1 ALOX5 ALOX5AP TBXAS1 PTGES PLCB1 PTGER1 TBXA2R PID_AJDISS_2PATHWAY%MSIGDB_C2%PID_AJDISS_2PATHWAY PID_AJDISS_2PATHWAY PTPN6 TIAM1 SRC CDC42 RAC1 CTNNA1 CDH2 RAB5A RAB7A hCG_1991735 ARF6 FYN PTPN1 CREBBP CABL1 JUP IGF1R SNX1 HRAS EGF CTNNB1 CASP3 RET ROBO1 SLIT1 DSP NTRK2 MMP7 BDNF MMP3 IGF2 HGS ADAM10 GNA13 ZBTB33 GDNF RIN2 CTNND1 MEP1B EGFR PID_ECADHERIN_STABILIZATION_PATHWAY%MSIGDB_C2%PID_ECADHERIN_STABILIZATION_PATHWAY PID_ECADHERIN_STABILIZATION_PATHWAY AQP5 LPP AQP3 LIMA1 MYO6 MGAT3 PLEKHA7 NCK1 CAMSAP3 KIFC3 ZYX DKFZp762K123 EXOC4 VASP CTNNA1 PIP5K1C ARF6 AFDN MYL2 STX4A NECTIN2 IGF1R ARHA EGF CTNNB1 HEL114 HGF ROCK1 ACTN1 EFNA1 EPHA2 CTNND1 CYFIP2 EGFR NCKAP1 BIOCARTA_NOTCH_PATHWAY%MSIGDB_C2%BIOCARTA_NOTCH_PATHWAY BIOCARTA_NOTCH_PATHWAY FURIN PSEN1 RBPJ NOTCH1 ADAM17 BIOCARTA_RANBP2_PATHWAY%MSIGDB_C2%BIOCARTA_RANBP2_PATHWAY BIOCARTA_RANBP2_PATHWAY RAN RANBP2 MDM2 SUMO1 HDAC1 PIAS1 HDAC4 DKFZp566E044 HDAC9 PIAS2 BIOCARTA_TH1TH2_PATHWAY%MSIGDB_C2%BIOCARTA_TH1TH2_PATHWAY BIOCARTA_TH1TH2_PATHWAY IFNGR1 IL4 IFNGR2 IFNG CD40 IL12RB1 IL18R1 NR1i2 CD40LG HLA-DRB5 IL12B HLA-DRB4 IL12A HLA-DRA HLA-DRB3 HLA-DRB1 IL2 IL18 IL2RA BIOCARTA_TALL1_PATHWAY%MSIGDB_C2%BIOCARTA_TALL1_PATHWAY BIOCARTA_TALL1_PATHWAY MAPK14 TRAF6 RELA CHUK TWEAK TRAF2 TNFSF13 DKFZp686J04131 TNFRSF13C TRAF3 TNFRSF17 TNLG7A TNFSF12-TNFSF13 NFKB1 MAPK8 BIOCARTA_CASPASE_PATHWAY%MSIGDB_C2%BIOCARTA_CASPASE_PATHWAY BIOCARTA_CASPASE_PATHWAY CASP10 CASP6 hCG_16983 LMNB2 CASP9 CASP3 PRF1 hCG_20684 CASP4 LMNA ARHGDIB DFFB DFFA PARP1 APAF1 BIRC2 BIRC3 BIOCARTA_IL1R_PATHWAY%MSIGDB_C2%BIOCARTA_IL1R_PATHWAY BIOCARTA_IL1R_PATHWAY IL6 JUN MAP2K3 MAPK14 IKBKB NFKBIA MAP3K1 TRAF6 RELA IL1RN CHUK IRAK1 IL1R1 DKFZp686J04131 IRAK3 IL1B MAP3K7 MAP2K6 MYD88 IRAK2 NFKB1 TGFB1 MAPK8 MAP3K7IP1 IL1A TNF-alpha IFNA1 IFNB1 BIOCARTA_EDG1_PATHWAY%MSIGDB_C2%BIOCARTA_EDG1_PATHWAY BIOCARTA_EDG1_PATHWAY MAPK1 PIK3R1 ARHA ADCY1 ITGB3 SMPD2 SMPD1 PLCB1 PDGFA RAC1 ITGAV PDGFRA SPHKAP PRKCB SPHK1 MAPK3 S1PR1 PRKCA PIK3CA BIOCARTA_MHC_PATHWAY%MSIGDB_C2%BIOCARTA_MHC_PATHWAY BIOCARTA_MHC_PATHWAY HLA-DRB4 HLA-DRA HLA-A HLA-DRB3 B2M HLA-DRB1 TAP1 PSMB6 CD74 TAP2 HLA-DRB5 PSM8 PID_TRAIL_PATHWAY%MSIGDB_C2%PID_TRAIL_PATHWAY PID_TRAIL_PATHWAY MAPK1 PIK3R3 PIK3CD PIK3R2 PIK3R1 IKBKB MAP2K4 TNFRSF10C MAP3K1 TNFRSF10A CHUK TNFRSF10D TRADD SMPD1 TRAF2 RIPK1 IKBKG DKFZp686A24188 MAPK3 PIK3CA MAPK8 TNFSF10 DAP3 CASP10 hCG_16983 FADD BIOCARTA_S1P_PATHWAY%MSIGDB_C2%BIOCARTA_S1P_PATHWAY BIOCARTA_S1P_PATHWAY SREBF2 LIMA1 MBTPS2 HMGCS1 LDLR BIOCARTA_NFKB_PATHWAY%MSIGDB_C2%BIOCARTA_NFKB_PATHWAY BIOCARTA_NFKB_PATHWAY MAP3K7IP1 IKBKB NFKBIA MAP3K1 TRAF6 TNFAIP3 RELA CHUK IL1A TRADD IL1R1 FADD DKFZp686J04131 TNFRSF1B TNFRSF1A RIPK1 TNF-alpha IKBKG MAP3K7 MYD88 NFKB1 PID_CIRCADIAN_PATHWAY%MSIGDB_C2%PID_CIRCADIAN_PATHWAY PID_CIRCADIAN_PATHWAY NONO NR1D1 CSNK1E NPAS2 PER2 PER1 CRY2 WDR5 CRY1 TIMELESS BHLHB2 ATR CHEK1 BIOCARTA_RARRXR_PATHWAY%MSIGDB_C2%BIOCARTA_RARRXR_PATHWAY BIOCARTA_RARRXR_PATHWAY TBP KAT2B NCOR2 NCOA1 RXRA RARA GTF2A1 BIOCARTA_RHO_PATHWAY%MSIGDB_C2%BIOCARTA_RHO_PATHWAY BIOCARTA_RHO_PATHWAY ARHGAP5 ARHGAP4 OPHN1 PIP5K1A ARHGEF1 ARHGEF11 ARHA HEL114 ARHGAP1 BAIAP2 STM7 PPP1R12B PFN1 ROCK1 LIMK1 ARHGEF5 TLN1 MYL2 BIOCARTA_EEA1_PATHWAY%MSIGDB_C2%BIOCARTA_EEA1_PATHWAY BIOCARTA_EEA1_PATHWAY EEA1 RAB5A TF HGS EGF DKFZp686O0451 EGFR PID_S1P_S1P3_PATHWAY%MSIGDB_C2%PID_S1P_S1P3_PATHWAY PID_S1P_S1P3_PATHWAY VEGFA GNA15 GNA11 MAPK1 GNAO1 ARHA AKT3 SRC ITGB3 GNAQ CXCR4 EDG5 RAC1 S1PR3 FLT1 ITGAV MAPK3 GNAZ GNA13 S1PR1 GNAI3 GNAI1 GNA14 BIOCARTA_SPRY_PATHWAY%MSIGDB_C2%BIOCARTA_SPRY_PATHWAY BIOCARTA_SPRY_PATHWAY CBL GRB2 MAPK1 SOS1 HRAS SHC1 EGF RAF1 SPRY4 PTPRB SPRY2 SPRY1 MAP2K1 MAPK3 EGFR BIOCARTA_GLEEVEC_PATHWAY%MSIGDB_C2%BIOCARTA_GLEEVEC_PATHWAY BIOCARTA_GLEEVEC_PATHWAY GRB2 STAT5B SOS1 HRAS JUN PIK3R1 FOS MAP2K4 BAD MAP3K1 RAF1 MYC STAT1 BCR MAP2K1 MAPK3 CRKL PIK3CA MAPK8 BIOCARTA_CCR3_PATHWAY%MSIGDB_C2%BIOCARTA_CCR3_PATHWAY BIOCARTA_CCR3_PATHWAY CCL11 MAPK1 ROCK2 HRAS CCR3 ARHA GNAQ PPP1R12B RAF1 PLCB1 LIMK1 MAP2K1 PRKCB PIK3C2G MAPK3 PRKCA MYL2 GNAS BIOCARTA_MCM_PATHWAY%MSIGDB_C2%BIOCARTA_MCM_PATHWAY BIOCARTA_MCM_PATHWAY CDC6 MCM6 MCM2 KITLG CDK2 CCNE1 CDKN1B ORC1L CDT1 MCM7 ORC2L ORC6L ORC3 MCM5 BIOCARTA_CERAMIDE_PATHWAY%MSIGDB_C2%BIOCARTA_CERAMIDE_PATHWAY BIOCARTA_CERAMIDE_PATHWAY BCL2 AIFM1 MAPK1 hCG_16983 MAP2K4 BAD MAP3K1 RELA TRADD SMPD1 RAF1 TRAF2 BAX FADD TNFRSF1A RIPK1 NSMAF MAP2K1 MAPK3 NFKB1 MAPK8 PID_HDAC_CLASSI_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSI_PATHWAY PID_HDAC_CLASSI_PATHWAY KAT2B RANBP2 HDAC4 DKFZp566E044 HDAC9 RBBP4 NCOR1 TNFRSF1A CREBBP MBD3 GATA2 HDAC7 RAN HDAC10 HDAC11 NCOR2 CHD4 CHD3 HDAC3 UBE2I MBD3L2 SUMO1 SMG5 PPARG SIRT4 SIRT5 NFKBIA SIRT6 STAT3 SIRT7 HDAC5 SIRT2 RELA WDR77 SAP30 SIRT3 SIN3B FKBP3 SIN3A ZFPM1 HDAC8 GATA1 SAP18 RBBP7 MTA2 MBD2 GATAD2B GATAD2A NFKB1 TFCP2 MXD1 SMURF1 HDAC1 MAX YY1 HDAC2 TNF-alpha EP300 SIRT1 BIOCARTA_ARAP_PATHWAY%MSIGDB_C2%BIOCARTA_ARAP_PATHWAY BIOCARTA_ARAP_PATHWAY GBF1 CLTB ASAP1 ARFGAP3 GPLD1 ARF1 CYTH3 ARAP1 CYTH2 ARAP2 ARFGEF1 ARFGEF2 COPA ASAP2 BIOCARTA_IFNA_PATHWAY%MSIGDB_C2%BIOCARTA_IFNA_PATHWAY BIOCARTA_IFNA_PATHWAY IFNAR2 STAT1 STAT2 JAK1 IFNAR1 TYK2 IFNA1 IRF9 IFNB1 BIOCARTA_FCER1_PATHWAY%MSIGDB_C2%BIOCARTA_FCER1_PATHWAY BIOCARTA_FCER1_PATHWAY MAPK1 CALM2 SYK JUN SHC1 PIK3R1 MAP2K4 MAP3K1 BTK NFATC4 LYN DKFZp434N101 MAP2K1 MAPK3 PIK3CA MAPK8 GRB2 SOS1 FCER1A HRAS FCER1G MS4A2 FOS NFATC3 RAF1 VAV1 HEL-S-72 PRKCB NFATC2 NFATC1 PPP3CA PPP3CC PID_TRKR_PATHWAY%MSIGDB_C2%PID_TRKR_PATHWAY PID_TRKR_PATHWAY NRAS DYNLT1 MAPK1 NGFR NGF TIAM1 KRAS NTRK1 SHC2 CDC42 RAP1A RAPGEF1 CRK RASGRF1 CCND1 SHC1 PIK3R1 STAT3 PRKCZ RAC1 ELMO1 PTPN11 DKFZp434N101 GAB2 MAP2K1 MAPK3 CRKL PIK3CA GRB2 PRKCI SOS1 MCF2L HRAS MATK ARHA FRS2 FRS3 FAIM SHC3 MAGED1 NTF5 NTF3 SH2B1 NTRK3 ARHG RIT1 NTRK2 RIT2 SQSTM1 BDNF DOCK1 PID_ERBB1_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ERBB1_DOWNSTREAM_PATHWAY PID_ERBB1_DOWNSTREAM_PATHWAY ARPC1B NRAS MAP3K2 MYLPF ACTR3 PPP5C RPS6KA5 ACTR2 MAPK1 CREB1 MAPKAP1 ATF1 MAP2K4 MLST8 KRAS RICTOR MAP3K1 SRC BRAF ARPC4 BAIAP2 ARPC2 CDC42 ARPC3 hCG_1991735 VAV2 HEL-S-34 FOS RIN1 PRKCA RALA PLD2 SFN PIK3R3 PIK3CD PIK3R2 JUN MAPK9 PIK3R1 BAD HEL2 STAT3 PRKCZ PPP2R2A PPP2R1A PPP2CA RAC1 RAB5A RPS6 MAP2K1 MTOR MAPK3 PIK3CA PDPK1 MAPK8 YWHAQ GRB2 SOS1 HEL-S-1 MAP2K2 BCL2L1 HRAS YWHAG F2RL2 EGF SMAD1 ATF2 YWHAZ RAF1 STAT1 USP6NL ARF4 MEF2C BRK1 RPS6KA4 WASL RPS6KA3 ZFP36 KSR1 SH2D2A CYFIP2 EGFR WASF2 NCKAP1 MAPK7 MAP2K5 EGR1 BIOCARTA_TEL_PATHWAY%MSIGDB_C2%BIOCARTA_TEL_PATHWAY BIOCARTA_TEL_PATHWAY BCL2 IGF1R XRCC5 TNKS TERF1 TEP1 KRAS RB1 TERT MYC PPP2CA PRKCA EGFR BIOCARTA_PCAF_PATHWAY%MSIGDB_C2%BIOCARTA_PCAF_PATHWAY BIOCARTA_PCAF_PATHWAY IRF4 KAT2B JUN IRF3 IRF2 IRF1 IRF7 ATF2 RELA IRF5 CREBBP HMGB1 NFKB1 BIOCARTA_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_MAPK_PATHWAY BIOCARTA_MAPK_PATHWAY MAP3K2 RPS6KA5 MAPK1 CREB1 MAP2K3 DKFZp686M02159 MAP2K4 MAPK11 RPS6KA2 MAP4K2 MAP3K8 MAP3K1 MAP3K6 CEBPA MAP3K12 CHUK MAPK6 TRADD MAPK4 RPS6KB2 TRAF2 MAP3K10 DKFZp686J04131 MAP3K13 MAPK13 RIPK1 MAP2K6 FOS RPS6KA1 JUN SHC1 MAPK9 MAPK14 IKBKB NFKBIA RELA MAPK10 MYC RAC1 MAP3K7 MAP2K1 MAPK3 NFKB1 HEL-S-31 TGFB1 RPS6KB1 MAPK8 TGFBR1 GRB2 MAP2K2 HRAS SP1 MAX MAP3K11 ATF2 MKNK1 MAP3K5 RAF1 STAT1 MAPKAPK2 RAPGEF2 MAPKAPK5 MAP4K1 RPS6KA4 MAPKAPK3 RPS6KA3 PAK1 MAPK7 MAP2K5 PID_FOXO_PATHWAY%MSIGDB_C2%PID_FOXO_PATHWAY PID_FOXO_PATHWAY RAN RBL2 KAT2B SFN RALB MAPK9 IKBKB GADD45A FOXO3 HEL2 SGK1 CHUK MAPK10 DKFZp564M2422 BCL6 BCL2L11 TNFSF6 CSNK1G3 SKP2 CSNK1D FBXO32 ZA20D2 CSNK1G2 CREBBP CSNK1G1 FOXO4 MAPK8 FOXO1 YWHAQ HEL-S-1 CDK2 CSNK1A1 CSNK1E YWHAG CTNNB1 YWHAZ CDKN1B G6PC1 EP300 PLK1 RALA SIRT1 CCNB1 PID_TCR_JNK_PATHWAY%MSIGDB_C2%PID_TCR_JNK_PATHWAY PID_TCR_JNK_PATHWAY JUN MAP2K4 MAP3K1 MAP3K8 LAT MAP3K7 MAP4K1 PRKCB GRAP2 CRKL LCP2 CRK MAPK8 BIOCARTA_ATRBRCA_PATHWAY%MSIGDB_C2%BIOCARTA_ATRBRCA_PATHWAY BIOCARTA_ATRBRCA_PATHWAY hCG_37731 TREX1 FANCA ATM HUS1 MRE11A FANCC FANCE FANCG FANCF RAD50 FANCD2 BRCA1 RAD17 RAD9A BRCA2 ATR CHEK1 NBN RAD51 CHEK2 PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY%MSIGDB_C2%PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY PID_ERBB1_RECEPTOR_PROXIMAL_PATHWAY NRAS PTPN6 MAPK1 PIK3R3 PIK3CD PIK3R2 NCK1 SHC1 PIK3R1 STAT3 KRAS SRC PIP5K1C PTPN11 DKFZp434N101 MAPK3 PTPN1 GNAI3 PIK3CA TLN1 GNAI1 GRB2 SOS1 HRAS NCK2 EGF STAT1 WASL DKFZp666O0110 EGFR PAK1 BIOCARTA_SODD_PATHWAY%MSIGDB_C2%BIOCARTA_SODD_PATHWAY BIOCARTA_SODD_PATHWAY BAG4 TRAF2 FADD TNFRSF1B TNFRSF1A RIPK1 TNF-alpha hCG_16983 BIRC3 TRADD BIOCARTA_TOLL_PATHWAY%MSIGDB_C2%BIOCARTA_TOLL_PATHWAY BIOCARTA_TOLL_PATHWAY EIF2AK2 MAP3K7IP1 JUN MAP2K3 MAPK14 FOS IKBKB MAP2K4 NFKBIA MAP3K1 TRAF6 RELA TLR7 CHUK DKFZp686J04131 IKBKG MAP3K7 MYD88 MAP2K6 NFKB1 NR1C1 PGLYRP1 MAPK8 TLR3 BIOCARTA_BARR_MAPK_PATHWAY%MSIGDB_C2%BIOCARTA_BARR_MAPK_PATHWAY BIOCARTA_BARR_MAPK_PATHWAY RAF1 PLCB1 MAPK1 MAP2K2 MAP2K1 ADCY1 MAPK3 KCNA1 KCNA2 KCNA3 ADRBK1 GNAS BIOCARTA_NKCELLS_PATHWAY%MSIGDB_C2%BIOCARTA_NKCELLS_PATHWAY BIOCARTA_NKCELLS_PATHWAY KLRC2 KLRC3 KLRC4 PTPN6 KLRD1 PTK2B KLRC1 SYK PIK3R1 ITGB1 LAT HLA-A RAC1 B2M VAV1 MAP2K1 MAPK3 PIK3CA IL18 PAK1 BIOCARTA_IGF1MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1MTOR_PATHWAY BIOCARTA_IGF1MTOR_PATHWAY IGF1 IGF1R PIK3R1 GSK3B PDK2 PPP2CA EIF2B5 INPPL1 EIF4E EIF2S2 MTOR EIF2S1 EIF2S3 PIK3CA PTEN RPS6KB1 EIF4EBP1 PDPK1 BIOCARTA_FAS_PATHWAY%MSIGDB_C2%BIOCARTA_FAS_PATHWAY BIOCARTA_FAS_PATHWAY CASP10 CASP6 FAF1 PTPN13 JUN RIPK2 hCG_16983 MAP2K4 RB1 MAP3K1 LMNB2 CASP3 FADD LMNA ARHGDIB TNFSF6 DFFB DFFA MAP3K7 PARP1 PRKDC PAK1 MAPK8 BIOCARTA_GABA_PATHWAY%MSIGDB_C2%BIOCARTA_GABA_PATHWAY BIOCARTA_GABA_PATHWAY GABRA2 GABRA6 GABRA5 GABRA4 GABRA3 UBQLN1 GPHN GABARAP BIOCARTA_NUCLEARRS_PATHWAY%MSIGDB_C2%BIOCARTA_NUCLEARRS_PATHWAY BIOCARTA_NUCLEARRS_PATHWAY NR1H4 ABCG1 NR1H3 NR1C2 NR1B3 NR1i1 RARA RARB PPARG NR1i2 NR1C1 ABCD2 ABCD3 ABCC3 NR1I3 ABCB1 CYP4A22 ABCB4 CYP3A4 CYP27B1 ABCB11 CYP2B6 ABCG5 ABCC2 CYP4A11 CYP4B1 CYP8B1 CYP26A1 ABCA1 NR0B2 CYP2C9 CYP24A1 CYP1A2 CYP2E1 PID_HES_HEY_PATHWAY%MSIGDB_C2%PID_HES_HEY_PATHWAY PID_HES_HEY_PATHWAY MYOD1 MAML2 KDM1A MAML1 RUNX2 GATA6 NCOA1 NCOR2 ASCL1 HEY1 BGLAP HEY2 SPEN RBPJ HES6 GAA STAT3 RCAN1 NOTCH1 ID1 PTF1A NEUROG3 RBBP8 NCOR1 MYB GATA1 CREBBP HES1 KDR GHR CTBP1 CAMK2D HDAC1 RB1 CDKN1B HIF1A GATA4 YY1 TWIST1 EP300 PARP1 TCF3 BIOCARTA_TCRA_PATHWAY%MSIGDB_C2%BIOCARTA_TCRA_PATHWAY BIOCARTA_TCRA_PATHWAY HLA-DRB5 CD3G HLA-DRB4 CD3E CD3D HLA-DRA HLA-DRB3 HLA-DRB1 CD247 ZAP70 FYN LCK PTPRC BIOCARTA_MTOR_PATHWAY%MSIGDB_C2%BIOCARTA_MTOR_PATHWAY BIOCARTA_MTOR_PATHWAY EIF4A1 EIF4G1 EIF3A PIK3R1 MKNK1 TSC1 RHEB PDK2 PPP2CA TSC2 EIF4E MTOR EIF4A2 AAG1 PIK3CA PTEN RPS6KB1 EIF4EBP1 PDPK1 PID_INTEGRIN3_PATHWAY%MSIGDB_C2%PID_INTEGRIN3_PATHWAY PID_INTEGRIN3_PATHWAY VEGFA COL4A6 COL4A5 THY1 COL1A1 ITGB3 F11R VTN EDIL3 L1CAM SDC1 ITGAV CD47 FBN1 PECAM1 SPHK1 HMGB1 KDR LAMA4 PLAUR LAMC1 TGFBR2 FGA LAMB1 opn SDC4 COL1A2 TNC ITGA2B HEL-S-78p THBS1 TGFBI IBSP COL4A1 COL4A4 COL4A3 PID_RAC1_REG_PATHWAY%MSIGDB_C2%PID_RAC1_REG_PATHWAY PID_RAC1_REG_PATHWAY KIAA0142 TIAM1 HEL-S-47e RAC1 ELMO1 DOCK2 ARHGAP17 PREX2 PREX1 VAV2 CHN1 ARHGAP9 RALBP1 TRIO SPATA13 ARHGEF25 SOS1 ARHGEF2 RASGRF1 VAV3 ARHGAP1 DKFZp781H1715 DEF6 VAV1 BCR DOCK1 KALRN PID_TOLL_ENDOGENOUS_PATHWAY%MSIGDB_C2%PID_TOLL_ENDOGENOUS_PATHWAY PID_TOLL_ENDOGENOUS_PATHWAY TLR1 CD14 TLR4 S100A9 S100A8 IKBKB ARHA CHUK IRAK1 HSPD1 VCAN IRAK4 IKBKG MYD88 IRAK2 HMGB1 LY96 TICAM1 TIRAP TLR3 BIOCARTA_HIVNEF_PATHWAY%MSIGDB_C2%BIOCARTA_HIVNEF_PATHWAY BIOCARTA_HIVNEF_PATHWAY NFKBIA MAP3K1 RELA CRADD CHUK TRADD hCG_20684 TRAF2 DKFZp686J04131 TNFRSF1A TNFSF6 RIPK1 MDM2 NFKB1 MAPK8 PSEN1 BCL2 CASP6 PSEN2 ACTG1 CDK11A hCG_16983 NUMA1 RB1 LMNB2 CASP9 CASP3 MAP3K5 BAG4 FADD LMNA ARHGDIB TRAF1 TNFRSF1B DFFB TNF-alpha DFFA PARP1 PRKDC APAF1 BIRC2 BIRC3 BIOCARTA_PKC_PATHWAY%MSIGDB_C2%BIOCARTA_PKC_PATHWAY BIOCARTA_PKC_PATHWAY PLCB1 PRKCB NFKBIA NFKB1 PRKCA RELA GNAQ BIOCARTA_ATM_PATHWAY%MSIGDB_C2%BIOCARTA_ATM_PATHWAY BIOCARTA_ATM_PATHWAY ATM JUN TP73 GADD45A MRE11A NFKBIA CDKN1A RELA RAD50 RBBP8 BRCA1 MDM2 CHEK1 NFKB1 NBN RAD51 CHEK2 MAPK8 PID_HDAC_CLASSII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSII_PATHWAY PID_HDAC_CLASSII_PATHWAY RAN HDAC10 RANBP2 HDAC11 NCOR2 GNB1 HDAC3 UBE2I SUMO1 HDAC4 HEL2 DKFZp566E044 HDAC5 HDAC9 BCL6 GATA1 CAMK4 NR3C1 HEL-S-1 TUBA1B RFXANK TUBB2A BCOR ANKRA2 GATA2 HDAC7 MEF2C GNG2 ADRBK1 BIOCARTA_NEUTROPHIL_PATHWAY%MSIGDB_C2%BIOCARTA_NEUTROPHIL_PATHWAY BIOCARTA_NEUTROPHIL_PATHWAY SELE CD44 ITGAM SELL PECAM1 BIOCARTA_CDK5_PATHWAY%MSIGDB_C2%BIOCARTA_CDK5_PATHWAY BIOCARTA_CDK5_PATHWAY RAF1 MAPK1 NGFR MAP2K2 CDK5 NGF DPM2 HRAS MAP2K1 MAPK3 CDK5R1 EGR1 PID_ILK_PATHWAY%MSIGDB_C2%PID_ILK_PATHWAY PID_ILK_PATHWAY KIAA0142 CREB1 JUN HEL-S-28 ZYX GSK3B RICTOR CDC42 RUVBL2 RAC1 RUVBL1 hCG_1991735 SNAI1 NCK2 CCND1 CTNNB1 AURKA ILKAP PPP1R14A TNS1 GIT2 PPP1R14B PPP1R14C PARVA PARVB ARHG hCG_2016482 PARVG CDC37 PARP1 ELMO2 PXN LIMS1 ACTN1 CKAP5 TACC3 PID_S1P_META_PATHWAY%MSIGDB_C2%PID_S1P_META_PATHWAY PID_S1P_META_PATHWAY GNA15 GNA11 GNAO1 GNAQ ABCC1 EDG5 S1PR3 SPHK2 SPHK1 SGPP1 GNAZ GNA13 SGPL1 S1PR1 GNAI3 S1PR5 GNAI1 S1PR4 GNA14 PID_ARF_3PATHWAY%MSIGDB_C2%PID_ARF_3PATHWAY PID_ARF_3PATHWAY GBF1 USO1 CLTB CLTA ASAP1 PLD2 PIP5K1A ARF1 CYTH2 RAC1 KDELR1 AP2A1 COPA GOSR2 AP2M1 PID_HEDGEHOG_2PATHWAY%MSIGDB_C2%PID_HEDGEHOG_2PATHWAY PID_HEDGEHOG_2PATHWAY STIL DHH HHIP PTCH2 IHH PTHLH SHH SMO PIK3R1 BOC PTCH1 CDON ARRB2 GAS1 PIK3CA LRPAP1 ADRBK1 BIOCARTA_ERYTH_PATHWAY%MSIGDB_C2%BIOCARTA_ERYTH_PATHWAY BIOCARTA_ERYTH_PATHWAY IGF1 IL3 IL6 KITLG CCL3 IL9 IL11 FLT3 IL1A CSF3 CSF2 TGFB1 EPO BIOCARTA_BTG2_PATHWAY%MSIGDB_C2%BIOCARTA_BTG2_PATHWAY BIOCARTA_BTG2_PATHWAY CHAF1A NGF BTG2 PRMT1 CCND1 RB1 CHAF1B BTG1 PID_EPHA_FWDPATHWAY%MSIGDB_C2%PID_EPHA_FWDPATHWAY PID_EPHA_FWDPATHWAY BLK YES1 c-fgr SRC EPHA7 EPHA8 UNQ6114 EFNA3 EFNA2 EPHA1 EPHA3 LYN DKFZp434N101 EPHA4 VAV2 FYN CRKL CRK LCK CBL CDK5 ARHA VAV3 ARHGEF15 ROCK1 PIK3R5 EFNA1 EFNA5 EPHA2 PID_ERB_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERB_GENOMIC_PATHWAY PID_ERB_GENOMIC_PATHWAY NR0B1 NCOA1 UBA3 DDX54 ZNF14 ESR2 SMARCE1 NR0B2 NEDD8 HEL-S-62p UBE2M SMARCA4 BIOCARTA_STAT3_PATHWAY%MSIGDB_C2%BIOCARTA_STAT3_PATHWAY BIOCARTA_STAT3_PATHWAY MAPK1 JAK3 JAK1 TYK2 MTOR MAPK3 STAT3 BIOCARTA_HSP27_PATHWAY%MSIGDB_C2%BIOCARTA_HSP27_PATHWAY BIOCARTA_HSP27_PATHWAY HEL-S-102 BCL2 TNFSF6 MAPKAPK2 TNF-alpha ACTA1 MAPKAPK3 APAF1 HSPB2-C11orf52 CASP9 IL1A CASP3 BIOCARTA_PEPI_PATHWAY%MSIGDB_C2%BIOCARTA_PEPI_PATHWAY BIOCARTA_PEPI_PATHWAY ELANE IL8 GRN CELA2A CELA3B SLPI ELA2B CELA1 PID_HDAC_CLASSIII_PATHWAY%MSIGDB_C2%PID_HDAC_CLASSIII_PATHWAY PID_HDAC_CLASSIII_PATHWAY FOXO1 MYOD1 ACSS2 FHL2 KAT2B MEF2D HOXA10 HIST1H1E HIST1H4J ACSS1 TUBA1B PPARGC1A HDAC4 FOXO3 TUBB2A SIRT7 CDKN1A SIRT2 SIRT3 BAX EP300 CREBBP SIRT1 FOXO4 PID_CD8_TCR_PATHWAY%MSIGDB_C2%PID_CD8_TCR_PATHWAY PID_CD8_TCR_PATHWAY NRAS PTPN6 PRKCE SHC1 IKBKB BCL10 KRAS MAP3K8 TRAF6 CHUK CD3G LAT PRF1 CD3E CD3D DKFZp686J04131 RAP1A HLA-A B2M IKBKG DKFZp434N101 CD247 FYN GRAP2 LCP2 LCK PDPK1 CBL GRB2 SOS1 HRAS FLJ00120 FLJ14466 PAG1 CD8B1 STIM1 CSK PRKCQ CD80 VAV1 PRKCB ZAP70 PRKCA CD8A PTPRC PID_P38_GAMMA_DELTA_PATHWAY%MSIGDB_C2%PID_P38_GAMMA_DELTA_PATHWAY PID_P38_GAMMA_DELTA_PATHWAY MAPK13 MAP2K6 MAP2K3 PKN1 DKFZp686M02159 CCND1 EEF2K SNTA1 BIOCARTA_PTEN_PATHWAY%MSIGDB_C2%BIOCARTA_PTEN_PATHWAY BIOCARTA_PTEN_PATHWAY GRB2 MAPK1 SOS1 HEL-S-28 SHC1 PIK3R1 FOXO3 ITGB1 CDKN1B PDK2 TNFSF6 MAPK3 PIK3CA PTEN EGFR PDPK1 PID_FRA_PATHWAY%MSIGDB_C2%PID_FRA_PATHWAY PID_FRA_PATHWAY CCNA2 IL6 BGLAP JUN LIF CXNK2 FOSL2 CCL2 FOSL1 ITGB4 CDKN2A PLAUR SP1 CCND1 MMP2 NFATC3 COL1A2 TXLNG LAMA3 THBD JUNB JUND USF2 DCN DMTF1 IL8 MGP IVL HMOX1 EP300 ATF4 NFATC2 NFATC1 MMP9 BIOCARTA_AHSP_PATHWAY%MSIGDB_C2%BIOCARTA_AHSP_PATHWAY BIOCARTA_AHSP_PATHWAY GATA1 ALAS2 ERAF UROD UROS HMBS ALAS1 CPOX HBB DKFZp686P18130 HBA2 BIOCARTA_IL7_PATHWAY%MSIGDB_C2%BIOCARTA_IL7_PATHWAY BIOCARTA_IL7_PATHWAY NMI IL7 BCL2 IL7R STAT5B PTK2B PIK3R1 JAK3 JAK1 EP300 CREBBP FYN PIK3CA LCK BIOCARTA_PLATELETAPP_PATHWAY%MSIGDB_C2%BIOCARTA_PLATELETAPP_PATHWAY BIOCARTA_PLATELETAPP_PATHWAY COL4A6 SERPINE1 COL4A5 PLG F11 APP PLAT COL4A2 COL4A1 COL4A4 COL4A3 BIOCARTA_CPSF_PATHWAY%MSIGDB_C2%BIOCARTA_CPSF_PATHWAY BIOCARTA_CPSF_PATHWAY CPSF4 CPSF1 PABPN1 CSTF3 CPSF3 CSTF2 CPSF2 PAPOLA CSTF1 PID_IL12_2PATHWAY%MSIGDB_C2%PID_IL12_2PATHWAY PID_IL12_2PATHWAY IL4 IFNG MAP2K3 CD3G IL12B CD3E IL12A CD3D MAP2K6 CD247 CCL4 CCL3 TYK2 FOS STAT4 CD8B1 IL12RB1 CCR5 IL18R1 NOS2 PPP3CA SOCS1 STAT6 RIPK2 MAPK14 IL2RG STAT3 IL18RAP RELA RELB PPP3R1 HLX IL1R1 TBX21 GADD45B HLA-A GZMA B2M NFKB2 TNFSF6 IL1B GADD45G RAB7A MTOR IL2 NFKB1 LCK IL2RA IL2RB ATF2 STAT1 HLA-DRA SPHK2 CD8A IL18 BIOCARTA_TCR_PATHWAY%MSIGDB_C2%BIOCARTA_TCR_PATHWAY BIOCARTA_TCR_PATHWAY CALM2 JUN SHC1 PIK3R1 MAP2K4 NFKBIA MAP3K1 RELA NFATC4 CD3G LAT CD3E CD3D RAC1 DKFZp434N101 CD247 MAP2K1 FYN MAPK3 NFKB1 PIK3CA LCK MAPK8 GRB2 SOS1 HRAS FOS NFATC3 RAF1 VAV1 HEL-S-72 PRKCB NFATC2 ZAP70 NFATC1 PRKCA PPP3CA PPP3CC BIOCARTA_CTCF_PATHWAY%MSIGDB_C2%BIOCARTA_CTCF_PATHWAY BIOCARTA_CTCF_PATHWAY TGFBR1 TGFBR2 TGFBR3 PIK3R1 SMAD1 CDKN1B DKFZp781O1323 MYC PPP2CA MDM2 CTCF CD79B CD79A MTOR SMAD4 TGFB1 PIK3CA PTEN RPS6KB1 CDKN2A BIOCARTA_MYOSIN_PATHWAY%MSIGDB_C2%BIOCARTA_MYOSIN_PATHWAY BIOCARTA_MYOSIN_PATHWAY PPP1R12B PLCB1 ARHGAP5 ARHGEF1 ROCK1 PKN1 PRKCB GNA13 PRKCA GNAQ PID_PRL_SIGNALING_EVENTS_PATHWAY%MSIGDB_C2%PID_PRL_SIGNALING_EVENTS_PATHWAY PID_PRL_SIGNALING_EVENTS_PATHWAY CCNA2 MAPK1 CDK2 ITGA1 TUBA1B CCNE1 ARHA ITGB1 CDKN1A SRC RAC1 ROCK1 hCG_2043376 RABGGTB MAPK3 RABGGTA PTP4A1 PTP4A2 PTP4A3 EGR1 ATF5 PID_CDC42_REG_PATHWAY%MSIGDB_C2%PID_CDC42_REG_PATHWAY PID_CDC42_REG_PATHWAY ITSN2 DOCK9 KIAA0142 FGD1 DOCK10 DOCK11 ARHGEF9 MCF2L HEL-S-47e VAV3 APC ARHGAP1 CDC42 ARHGAP17 FARP2 DKFZp434N101 ITSN1 VAV2 RALBP1 SPATA13 ARHGEF25 BIOCARTA_FIBRINOLYSIS_PATHWAY%MSIGDB_C2%BIOCARTA_FIBRINOLYSIS_PATHWAY BIOCARTA_FIBRINOLYSIS_PATHWAY SERPINE1 PLG HEL-S-78p CPB2 SERPINB2 F2R F13A1 PLAT FGA PID_NETRIN_PATHWAY%MSIGDB_C2%PID_NETRIN_PATHWAY PID_NETRIN_PATHWAY MAPK1 YES1 NCK1 PIK3R1 SRC AGAP2 CAMK2A CDC42 RAC1 ELMO1 DKFZp434N101 MAP2K1 FYN MAPK3 TRIO PIK3CA MAP2K2 MAP1B HEL-S-36 ARHA NTN1 MYO10 UNC5A UNC5B DCC DOCK1 WASL DKFZp666O0110 PAK1 PID_FCER1_PATHWAY%MSIGDB_C2%PID_FCER1_PATHWAY PID_FCER1_PATHWAY MAPK1 MAP2K4 BTK MAP3K1 CHUK LAT IKBKG SPHK1 S1PR1 LCP2 PTPN13 FOS PRKCB NFATC2 PLD2 SYK JUN SHC1 IKBKB PIK3R1 RELA Pe1Fe6 LYN PTPN11 DKFZp434N101 GAB2 MAP2K1 FYN MAPK3 NFKB1 PIK3CA MAPK8 ITK CBL GRB2 SOS1 MAP2K2 FCER1A HRAS FCER1G MS4A2 WIPF1 LAT2 RAF1 DOK1 PPAP2A HCLS1 PLA2G1B VAV1 FCGR2B PXN DKFZp666O0110 BIOCARTA_COMP_PATHWAY%MSIGDB_C2%BIOCARTA_COMP_PATHWAY BIOCARTA_COMP_PATHWAY C7 C9 MASP2 MASP1 MBL2 HEL-S-62p CFD ADIB C1S ADIA C1R C4B_2 C8A C2 C4A C6 BIOCARTA_SET_PATHWAY%MSIGDB_C2%BIOCARTA_SET_PATHWAY BIOCARTA_SET_PATHWAY PRF1 GZMA DFFB SET DFFA APEX1 HMGB2 CREBBP BIOCARTA_AMAN_PATHWAY%MSIGDB_C2%BIOCARTA_AMAN_PATHWAY BIOCARTA_AMAN_PATHWAY FUT4 FUT6 FUT5 FUT7 MAN2A2 FUT9 MAN1A2 B3GALT2 B3GALT1 ST8SIA4 MAN1A1 MAN2C1 SIAT4C PID_BETA_CATENIN_NUC_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_NUC_PATHWAY PID_BETA_CATENIN_NUC_PATHWAY APC TBXT RUVBL2 TCF7L1 ZCCHC12 CHD8 CBY1 CAMK4 DKFZp586H0919 FGF4 MED12 SALL4 PP2150 PITX2 TLE4 CDKN2A MYOG TLE2 DKFZp586M1622 KRT1 CTNNBIP1 AXIN2 DKK4 MDFIC TBL1XR1 CACNA1G IGF2BP1 COX2 TBL1X CCND1 TCF7L2 CDX4 CDX1 BCL9 SKP1 SP5 TCF4 NEUROG1 MYF5 INCENP DKK1 SFN ID2 JUN MITF-C HEL2 TERT SMARCA4 CCND2 MYC SNAI2 YWHAQ CTBP1 HEL-S-1 YWHAG HDAC1 MMP2 CTNNB1 YWHAZ TRRAP VCAN HDAC2 IL8 TNIK EP300 MMP9 BIOCARTA_GH_PATHWAY%MSIGDB_C2%BIOCARTA_GH_PATHWAY BIOCARTA_GH_PATHWAY GHR SLC2A4 GH1 GRB2 PTPN6 STAT5B MAPK1 SOS1 SOCS1 HRAS SHC1 PIK3R1 HNF1A RAF1 IRS1 DKFZp434N101 INSR MAP2K1 PRKCB MAPK3 PRKCA PIK3CA RPS6KA1 PID_IL5_PATHWAY%MSIGDB_C2%PID_IL5_PATHWAY PID_IL5_PATHWAY CSF2RB GRB2 STAT5B IL5 IL5RA PIM1 SDCBP LYN PTPN11 PIK3R1 CISH PIK3CA BIOCARTA_CLASSIC_PATHWAY%MSIGDB_C2%BIOCARTA_CLASSIC_PATHWAY BIOCARTA_CLASSIC_PATHWAY C7 C9 ADIB C1S ADIA C1R C4B_2 C8A C2 C4A HEL-S-62p C6 BIOCARTA_IL2RB_PATHWAY%MSIGDB_C2%BIOCARTA_IL2RB_PATHWAY BIOCARTA_IL2RB_PATHWAY NMI PTPN6 MAPK1 SOCS3 SOCS1 SYK SHC1 PIK3R1 BAD IL2RG MYC JAK3 TNFSF6 JAK1 MAPK3 CRKL PIK3CA RPS6KB1 IL2RA CBL IL2RB BCL2 GRB2 STAT5B SOS1 HRAS FOS RAF1 IKZF3 HEL-S-69p IRS1 BIOCARTA_HES_PATHWAY%MSIGDB_C2%BIOCARTA_HES_PATHWAY BIOCARTA_HES_PATHWAY DVL1 FZD1 HES7 HEY2 DKFZp434N181 WNT1 RBPJ HES1 GSK3B NOTCH1 HNF1A PID_LKB1_PATHWAY%MSIGDB_C2%PID_LKB1_PATHWAY PID_LKB1_PATHWAY STK11IP STRADB ETV4 SFN STK26 CREB1 SIK1 SNF1LK2 HEL2 MLST8 GSK3B TSC1 MYC PRKAG1 SMARCD3 MTOR SMAD4 EZR YWHAQ PSEN2 HEL-S-1 YWHAG PRKAA1 PRKAA2 HEL-S-130P YWHAZ raptor TSC2 CDC37 PRKAB1 BRSK1 CRTC2 CAB39 AKT1S1 STK11 KIAA0999 MAP2 MARK4 STRADA PID_DNA_PK_PATHWAY%MSIGDB_C2%PID_DNA_PK_PATHWAY PID_DNA_PK_PATHWAY XRCC5 CSNK2A1 POLM PNKP CSNK2A2 PRKDC APLF DNTT APTX CSNK2B NHEJ1 PID_TCR_PATHWAY%MSIGDB_C2%PID_TCR_PATHWAY PID_TCR_PATHWAY NRAS NCK1 PRKCE KRAS MAP3K8 TRAF6 CHUK CD3G LAT CD3E CD3D DKFZp686J04131 CDC42 RAP1A IKBKG CD247 GRAP2 LCP2 FLNA FLJ00120 FLJ14466 PAG1 STIM1 CSK PRKCB ZAP70 PRKCA PTPN6 SHC1 IKBKB BCL10 SLA2 WAS STK39 FYB1 PTPN11 DKFZp434N101 GAB2 FYN PTEN LCK PDPK1 ITK CBL GRB2 SOS1 HRAS PRKCQ CD80 HLA-DRA VAV1 MAP4K1 PTPRC PID_TCR_RAS_PATHWAY%MSIGDB_C2%PID_TCR_RAS_PATHWAY PID_TCR_RAS_PATHWAY NRAS RAF1 MAPK1 HRAS MAP2K1 PRKCB FOS MAPK3 KRAS PRKCA MAP3K8 BRAF BIOCARTA_LEPTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LEPTIN_PATHWAY BIOCARTA_LEPTIN_PATHWAY LEPR ACACA LEP CPT1A PRKAG1 PRKAB1 PRKAA1 PRKAB2 PRKAA2 PRKAG2 PRKAG3 BIOCARTA_TOB1_PATHWAY%MSIGDB_C2%BIOCARTA_TOB1_PATHWAY BIOCARTA_TOB1_PATHWAY IL4 TGFBR1 TGFBR2 TGFBR3 IFNG CD3G CD3E CD3D TOB2 TOB1 CD247 IL2 SMAD4 TGFB1 IL2RA PID_S1P_S1P4_PATHWAY%MSIGDB_C2%PID_S1P_S1P4_PATHWAY PID_S1P_S1P4_PATHWAY CDC42 MAPK1 DKFZp434N101 GNAO1 ARHA MAPK3 GNA13 GNAZ GNAI3 S1PR5 S1PR4 GNAI1 BIOCARTA_FOSB_PATHWAY%MSIGDB_C2%BIOCARTA_FOSB_PATHWAY BIOCARTA_FOSB_PATHWAY GRIA2 JUND PPP1R1B CDK5 FOSB BIOCARTA_LECTIN_PATHWAY%MSIGDB_C2%BIOCARTA_LECTIN_PATHWAY BIOCARTA_LECTIN_PATHWAY C7 C9 MASP2 MASP1 MBL2 C4B_2 C8A C2 C4A HEL-S-62p C6 BIOCARTA_GHRELIN_PATHWAY%MSIGDB_C2%BIOCARTA_GHRELIN_PATHWAY BIOCARTA_GHRELIN_PATHWAY GH1 IGF1 IGFBP5 IGFBP1 SST DKFZp667A016 GHRH IGFBP2 IGFBP4 GHRL IGFALS IGFBP6 BIOCARTA_IL6_PATHWAY%MSIGDB_C2%BIOCARTA_IL6_PATHWAY BIOCARTA_IL6_PATHWAY IL6 GRB2 SOS1 CSNK2A1 IL6ST HRAS IL6R JUN SHC1 FOS STAT3 RAF1 JAK3 JAK1 PTPN11 MAP2K1 MAPK3 CEBPB PID_IL27_PATHWAY%MSIGDB_C2%PID_IL27_PATHWAY PID_IL27_PATHWAY GATA3 IL27RA IL6 STAT2 IFNG IL6ST IL17A TYK2 STAT4 IL12RB1 STAT3 IL12B IL12A TBX21 STAT1 IL1B JAK1 TNF-alpha IL2 TGFB1 EBI3 IL18 IL27 BIOCARTA_DREAM_PATHWAY%MSIGDB_C2%BIOCARTA_DREAM_PATHWAY BIOCARTA_DREAM_PATHWAY OPRK1 CREB1 JUN PRKAR1B FOS MAPK3 PRKAR1A PRKACG CREM BIOCARTA_ECM_PATHWAY%MSIGDB_C2%BIOCARTA_ECM_PATHWAY BIOCARTA_ECM_PATHWAY ARHGAP5 MAPK1 HRAS SHC1 PIK3R1 ARHA ITGB1 RAF1 PFN1 ROCK1 MAP2K1 FYN MAPK3 PIK3CA TLN1 MYL2 BIOCARTA_PTDINS_PATHWAY%MSIGDB_C2%BIOCARTA_PTDINS_PATHWAY BIOCARTA_PTDINS_PATHWAY PFKL PFKM PFKP GSK3A ARF1 PRKCE ARHGEF2 BAD GSK3B PRKCZ BTK EEA1 RAC1 RAB5A LYN DKFZp434N101 VAV2 RPS6KB1 AP2A1 PDPK1 AP2M1 PID_INTEGRIN_A9B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A9B1_PATHWAY PID_INTEGRIN_A9B1_PATHWAY VEGFA ADAM12 VCAM1 VEGFC HEL-S-45 KCNJ15 VEGFD ADAM2 ADAM15 ADAM8 F13A1 PAOX ITGB1 opn SRC TNC RAC1 CSF2 PXN CSF2RA NOS2 BIOCARTA_CK1_PATHWAY%MSIGDB_C2%BIOCARTA_CK1_PATHWAY BIOCARTA_CK1_PATHWAY PLCB1 PPP2CA PPP1R1B CDK5 CSNK1D PRKAR1B DRD1 DRD2 PRKAR1A CDK5R1 PRKACG PPP3CA PID_IL23_PATHWAY%MSIGDB_C2%PID_IL23_PATHWAY PID_IL23_PATHWAY IL6 SOCS3 IFNG CXCL9 IL17A PIK3R1 NFKBIA STAT3 RELA IL18RAP IL12B CD3E IL1B CCL2 IL2 NFKB1 PIK3CA TYK2 STAT4 IL12RB1 IL23R IL24 IL18R1 ALOX12B CXCL1 MPO IL19 IL23A STAT1 IL17F TNF-alpha NOS2 IL18 BIOCARTA_IL10_PATHWAY%MSIGDB_C2%BIOCARTA_IL10_PATHWAY BIOCARTA_IL10_PATHWAY IL6 STAT1 HEL-S-10 IL10RB IL10RA JAK1 TNF-alpha HMOX1 IL10 STAT3 IL1A PID_INTEGRIN4_PATHWAY%MSIGDB_C2%PID_INTEGRIN4_PATHWAY PID_INTEGRIN4_PATHWAY LAMC1 ITGA6 LAMB3 LAMB2 LAMA5 LAMB1 ITGB4 LAMA1 LAMA3 LAMC2 BIOCARTA_AMI_PATHWAY%MSIGDB_C2%BIOCARTA_AMI_PATHWAY BIOCARTA_AMI_PATHWAY COL4A6 COL4A5 F2R FGA F10 PLG HEL-S-78p TFPI PROC PROS1 F7 ERAF PLAT COL4A2 COL4A1 COL4A4 SERPINC1 COL4A3 PID_TCR_CALCIUM_PATHWAY%MSIGDB_C2%PID_TCR_CALCIUM_PATHWAY PID_TCR_CALCIUM_PATHWAY IL4 IL3 IFNG JUN RCAN1 CD40LG PPP3R1 TNFSF6 CSF2 IL2 FOSL1 IL2RA POU2F1 FKBP1A FOS PTGS2 NFATC3 JUNB AKAP5 CHP1 BATF3 NFATC2 NFATC1 CABIN1 PPP3CA BIOCARTA_LDL_PATHWAY%MSIGDB_C2%BIOCARTA_LDL_PATHWAY BIOCARTA_LDL_PATHWAY IL6 LPL CCL2 ACAT1 LDLR CSF1 BIOCARTA_CACAM_PATHWAY%MSIGDB_C2%BIOCARTA_CACAM_PATHWAY BIOCARTA_CACAM_PATHWAY CAMK1 CALM2 CAMK1G CREB1 CAMK4 HEL-S-72 CAMKK1 CAMKK2 PID_ERA_GENOMIC_PATHWAY%MSIGDB_C2%PID_ERA_GENOMIC_PATHWAY PID_ERA_GENOMIC_PATHWAY DKFZp761B2210 SRA1 PHB2 PDIA2 DSCAM LMO4 SET AP1B1 SAFB LCOR PGR TRIM59 HDAC4 POU4F1 TFF1 PRDM15 POU4F2 ATP5J CHUK HSF2 NDUFV3 XBP1 NCOR1 ABCA3 EBAG9 UBA3 DDX54 ESR2 CEBPB KLRC3 NR0B1 AXIN2 GREB1 HEL-S-130P CCND1 CD82 NEDD8 HEL-S-62p UBE2M NR0B2 NCOA1 NCOR2 MED1 JUN PRL MYC COL18A1 SMAD4 HDAC1 BRCA1 PCNA EP300 HEL-S-44 CALCOCO1 MPG PID_ATR_PATHWAY%MSIGDB_C2%PID_ATR_PATHWAY PID_ATR_PATHWAY CCNA2 MCM2 PPP2R1A PPP2CA SMARCAL1 CEP164 PPP2R2B MDM2 BRCA2 CHEK1 NBN RFC3 RAD51 RFC4 CDC6 hCG_37731 RFC2 TREX1 HEL-S-1 CDK2 RPA1 HUS1 YWHAZ TIMELESS FANCD2 RAD17 CLSPN RAD9A ATR TOPBP1 PLK1 MCM7 BIOCARTA_CD40_PATHWAY%MSIGDB_C2%BIOCARTA_CD40_PATHWAY BIOCARTA_CD40_PATHWAY IKBKB CD40 NFKBIA MAP3K1 TRAF6 TNFAIP3 RELA CHUK CD40LG DKFZp686J04131 TRAF3 IKBKAP IKBKG NFKB1 PID_AVB3_INTEGRIN_PATHWAY%MSIGDB_C2%PID_AVB3_INTEGRIN_PATHWAY PID_AVB3_INTEGRIN_PATHWAY COL4A6 COL4A5 MAPK1 HEL-S-28 SRC ITGB3 F11R ITGAV COL16A1 COL14A1 COL12A1 PIK3C2A COL10A1 TEM5 TLN1 KDR COL2A1 COL6A1 ANGPTL3 COL8A2 COL8A1 IGF1R COL13A1 COL11A2 PIK4CA COL5A2 COL9A1 COL9A3 PI4KB COL9A2 HEL114 IRS1 VEGFA PIK3R1 CSF1R COL1A1 CSF1 VTN EDIL3 RAC1 SDC1 PTPN11 MAPK3 COL17A1 PIK3CA RPS6KB1 CBL TGFBR2 PTK2B hCG_16983 ARHA VAV3 opn COL3A1 COL1A2 CDKN1B FGF2 ROCK1 PXN DKFZp666O0110 COL4A1 COL4A4 COL4A3 PID_EPHA2_FWD_PATHWAY%MSIGDB_C2%PID_EPHA2_FWD_PATHWAY PID_EPHA2_FWD_PATHWAY CBL GRB2 ARHGAP35 TIAM1 SHC1 PIK3R1 ARHA VAV3 SRC RAC1 INPPL1 VAV2 EFNA1 DKFZp666O0110 PIK3CA EPHA2 PAK1 BIOCARTA_AGPCR_PATHWAY%MSIGDB_C2%BIOCARTA_AGPCR_PATHWAY BIOCARTA_AGPCR_PATHWAY PRKAR1B PRKCB GRK4 PRKAR1A PRKACG PRKCA GNAS PID_INSULIN_PATHWAY%MSIGDB_C2%PID_INSULIN_PATHWAY PID_INSULIN_PATHWAY INS NCK1 SHC1 PIK3R1 FOXO3 DKFZp762K123 PRKCZ DKFZp686P1551 SGK1 EXOC4 GRB10 EXOC6 PARD6A EXOC5 EXOC2 HEL-S-42 PTPN11 EXOC1 INSR PTPN1 RAPGEF1 PIK3CA RPS6KB1 TRIP10 CRK PDPK1 CBL GRB14 GRB2 PRKCI SOS1 HRAS NCK2 F2RL2 SH2B2 PTPRA DOK1 IRS1 EIF4EBP1 BIOCARTA_PARKIN_PATHWAY%MSIGDB_C2%BIOCARTA_PARKIN_PATHWAY BIOCARTA_PARKIN_PATHWAY UBE2G2 SNCAIP SEPT5 SNCA SUMO1 UBE2F GPR37 UBE2G1 BIOCARTA_VITCB_PATHWAY%MSIGDB_C2%BIOCARTA_VITCB_PATHWAY BIOCARTA_VITCB_PATHWAY COL4A6 COL4A5 P4HB SLC23A2 SLC23A1 SLC2A3 COL4A2 COL4A1 COL4A4 COL4A3 PID_IL8_CXCR1_PATHWAY%MSIGDB_C2%PID_IL8_CXCR1_PATHWAY PID_IL8_CXCR1_PATHWAY CBL GNA15 GNB1 PRKCE c-fgr PLCB3 ARRB2 PLCB1 PLCB2 IL8 RAB5A CXCR1 LYN PRKCB PRKCA GNA14 GNG2 ADRBK1 PDPK1 PID_BETA_CATENIN_DEG_PATHWAY%MSIGDB_C2%PID_BETA_CATENIN_DEG_PATHWAY PID_BETA_CATENIN_DEG_PATHWAY AXIN1 DKFZp586M1622 DVL1 AXIN2 DVL2 GSK3A CSNK1A1 CSNK1E FZD5 WNT3A CTNNB1 GSK3B APC SKP1 LRP6 CSNK1D PID_IL3_PATHWAY%MSIGDB_C2%PID_IL3_PATHWAY PID_IL3_PATHWAY CSF2RB IL3 IL3RA GRB2 STAT5B PIM1 BCL2L1 SHC1 HDAC1 YWHAG PIK3R1 ID1 YWHAZ PTPN11 SRP9 GAB2 CNKSR1 CISH CEBPB OSM PIK3CA PRKACG PID_AP1_PATHWAY%MSIGDB_C2%PID_AP1_PATHWAY PID_AP1_PATHWAY IL4 IL6 IL5 CREB1 IFNG TH BCL2L11 CSF2 FOSL2 CCL2 CDKN2A NR3C1 CDC2 DKFZp686H0575 EDN1 FOS CCND1 TCF7L2 NFATC3 JUNB JUND GATA2 HIF1A DMTF1 hCG_1991559 CRTC1 DMP1 NFATC2 MT2A ATF3 NFATC1 CBFB NTS BAG1 PENK FABP4 TRIP6 COPS5 JUN MYC MYB HLA-A FOSB CXNK2 ACTA1 NPPA IL2 FOSL1 TGFB1 PTEN TIMP1 SP1 CTNNB1 ATF2 COL1A2 CDKN1B IL8 EP300 IL10 MMP9 EGR1 PID_HNF3A_PATHWAY%MSIGDB_C2%PID_HNF3A_PATHWAY PID_HNF3A_PATHWAY SERPINA1 INS SFTPD SFTPA2 C4BPB DSCAM DKFZp686I24235 NKX3-1 AP1B1 JUN GCG NR2F2 PISD NFIA NFIB TFF1 PRDM15 SCGB1A1 ATP5J NDUFV3 XBP1 VTN KLK3 COL18A1 CREBBP CEBPB APOB POU2F1 SP1 FOXA1 SHH FOS CDKN1B BRCA1 FOXA3 FOXA2 EP300 HEL-S-44 BIOCARTA_MALATEX_PATHWAY%MSIGDB_C2%BIOCARTA_MALATEX_PATHWAY BIOCARTA_MALATEX_PATHWAY PDHA1 ME1 CS SLC25A11 HEL-S-32 SLC25A1 ACLY PC BIOCARTA_CDMAC_PATHWAY%MSIGDB_C2%BIOCARTA_CDMAC_PATHWAY BIOCARTA_CDMAC_PATHWAY MAPK1 HRAS JUN FOS NFKBIA RELA RAF1 MYC PLCB1 CUZD1 TNF-alpha MAP2K1 PRKCB MAPK3 NFKB1 PRKCA BIOCARTA_SM_PATHWAY%MSIGDB_C2%BIOCARTA_SM_PATHWAY BIOCARTA_SM_PATHWAY SNRPB U2AF1 SNRPD2 SNRPD1 SNRPG SNRPB2 SNRPE SNRPA1 SNRPF SNRPD3 DKFZp434N041 SNRPC SNRPA PID_ALK1_PATHWAY%MSIGDB_C2%PID_ALK1_PATHWAY PID_ALK1_PATHWAY ACVRL1 INHBA TGFBR1 ACVR2B TGFBR2 MAPK1 ACVR2A FKBP1A ACVR1 SMAD1 CSNK2B BMPR2 ID1 ENG TLX2 DKFZp781O1323 SMAD9 ARRB2 MAPK3 SMAD4 TGFB1 BIOCARTA_MCALPAIN_PATHWAY%MSIGDB_C2%BIOCARTA_MCALPAIN_PATHWAY BIOCARTA_MCALPAIN_PATHWAY CAPNS1 EZR CAPNS2 HRAS EGF CXCR3 ITGB1 ACTA1 PRKAR1B PRKAR1A PRKACG TLN1 MYL2 EGFR BIOCARTA_HSWI_SNF_PATHWAY%MSIGDB_C2%BIOCARTA_HSWI_SNF_PATHWAY BIOCARTA_HSWI_SNF_PATHWAY NR3C1 TBP NF1 PS1TP5BP1 SMARCE1 SMARCD1 SMARCC1 GTF2A1 SMARCC2 ARID1A SMARCA4 BIOCARTA_TFF_PATHWAY%MSIGDB_C2%BIOCARTA_TFF_PATHWAY BIOCARTA_TFF_PATHWAY GHR GH1 GRB2 MAPK1 SOS1 ERBB2 TFF2 HRAS SHC1 PIK3R1 ARHA BAD CTNNB1 TFF1 ITGB1 TFF3 CASP9 MAPK3 APAF1 PIK3CA EGFR BIOCARTA_CARM1_PATHWAY%MSIGDB_C2%BIOCARTA_CARM1_PATHWAY BIOCARTA_CARM1_PATHWAY CREB1 RXRA RARA EP300 PRKAR1B CREBBP PRKAR1A PRKACG CARM1 BIOCARTA_BCELLSURVIVAL_PATHWAY%MSIGDB_C2%BIOCARTA_BCELLSURVIVAL_PATHWAY BIOCARTA_BCELLSURVIVAL_PATHWAY JUND DPF2 BIRC5 ZBTB7A PIK3R1 FOS MTOR CCT4 ITGB1 PIK3CA CASP3 BIOCARTA_PROTEASOME_PATHWAY%MSIGDB_C2%BIOCARTA_PROTEASOME_PATHWAY BIOCARTA_PROTEASOME_PATHWAY RPN1 UBE3A UBE2A UBE1 PSMA4 HEL-S-276 PSMB6 RPN2 PSMB2 PSMA2 PSMB3 BIOCARTA_TCAPOPTOSIS_PATHWAY%MSIGDB_C2%BIOCARTA_TCAPOPTOSIS_PATHWAY BIOCARTA_TCAPOPTOSIS_PATHWAY CD3E CD3D TNFSF6 CD247 CCR5 CD3G BIOCARTA_PLCD_PATHWAY%MSIGDB_C2%BIOCARTA_PLCD_PATHWAY BIOCARTA_PLCD_PATHWAY HEL-S-45 ADRA1B PRKCB PRKCA BIOCARTA_TPO_PATHWAY%MSIGDB_C2%BIOCARTA_TPO_PATHWAY BIOCARTA_TPO_PATHWAY GRB2 STAT5B SOS1 CSNK2A1 HRAS JUN SHC1 PIK3R1 FOS STAT3 RAF1 STAT1 MPL THPO DKFZp434N101 MAP2K1 PRKCB MAPK3 PRKCA PIK3CA BIOCARTA_RHODOPSIN_PATHWAY%MSIGDB_C2%BIOCARTA_RHODOPSIN_PATHWAY BIOCARTA_RHODOPSIN_PATHWAY GRK1 RCVRN SLC25A18 PDE6G RHO SAG PDE6A SLC25A22 PID_SHP2_PATHWAY%MSIGDB_C2%PID_SHP2_PATHWAY PID_SHP2_PATHWAY NRAS IL6 LMO4 NGF IFNG KRAS NTRK1 AFDN KDR IFNGR1 IGF1R ANGPT1 PAG1 IRS1 VEGFA SHC1 PIK3R1 IL2RG JAK3 JAK1 PTPN11 GAB2 MAP2K1 IL2 PIK3CA GNAI3 GNAI1 LCK IL2RA IL2RB GRB2 ARHGAP35 SOS1 MAP2K2 IL6ST HRAS IL6R ARHA FRS2 EGF FRS3 NTF5 RAF1 NTF3 STAT1 NTRK3 NTRK2 BDNF SDC2 EGFR PID_CERAMIDE_PATHWAY%MSIGDB_C2%PID_CERAMIDE_PATHWAY PID_CERAMIDE_PATHWAY PRKRA AIFM1 MAPK1 EIF2AK2 MAP2K4 BAD NFKBIA PRKCZ MAP3K1 RELA CRADD TRADD SMPD1 MYC TRAF2 BAX PDGFA TNFRSF1A RIPK1 MAP2K1 MAPK3 NFKB1 HEL-S-31 MAPK8 BCL2 MAP2K2 hCG_16983 EGF HEL-S-130P BAG4 RAF1 FADD TNF-alpha SPHK2 MADD KSR1 CYCS BIRC3 PAWR PID_PDGFRB_PATHWAY%MSIGDB_C2%PID_PDGFRB_PATHWAY PID_PDGFRB_PATHWAY ARPC1B NRAS SLA DKFZp686P11128 ACTR3 ACTN4 ACTR2 MAPK1 BLK SLC9A3R2 DOCK4 YES1 MYOCD NCK1 ACTA2 HEL-S-47e SIPA1 c-fgr KRAS BRAF ARPC4 BAIAP2 ARPC2 ARPC3 PIN1 RAB4A FOS PRKCA EIF2AK2 SHC1 PIK3R1 HEL2 MYC GRB10 PPP2CA RAC1 LYN PTPN11 FYN PTPN1 PIK3CA LCK MAPK8 GRB2 SOS1 MAP2K2 ARHA RAF1 CYFIP2 NCKAP1 PRKCE MAP2K4 SRC ITGB3 RAP1A ITGAV PPP2R2B hCG_1991735 VAV2 AFDN SPHK1 RAPGEF1 S1PR1 CRK STAT5B PAG1 CSK JUND PIK3R5 SLC9A3R1 SFN PIK3R3 PIK3CD PIK3R2 JUN MAPK9 STAT3 MAPK10 PPP2R1A RAB5A DKFZp434N101 MAP2K1 MAPK3 PTEN CBL YWHAQ ARHGAP35 HEL-S-1 HRAS NCK2 YWHAG YWHAZ DOK1 STAT1 ARAP1 USP6NL BRK1 RPS6KA3 WASL KSR1 WASF2 PAK1 PID_RHODOPSIN_PATHWAY%MSIGDB_C2%PID_RHODOPSIN_PATHWAY PID_RHODOPSIN_PATHWAY LRAT GNB1 GNB5 SLC24A1 GNGT1 CNGA1 GNAT1 GUCY2D DKFZp686E1183 GUCA1C GUCY2F RPE65 GRK1 RDH12 PDE6G RGS9BP RHO SAG PDE6A RDH5 BIOCARTA_RNA_PATHWAY%MSIGDB_C2%BIOCARTA_RNA_PATHWAY BIOCARTA_RNA_PATHWAY DKFZp686J04131 EIF2AK2 EIF2S2 NFKBIA EIF2S1 NFKB1 DNAJC3 RELA CHUK BIOCARTA_NO1_PATHWAY%MSIGDB_C2%BIOCARTA_NO1_PATHWAY BIOCARTA_NO1_PATHWAY VEGFA FLT4 CHRNA1 CALM2 BDKRB2 CHRM1 RYR2 PDE3B PDE2A SLC7A1 TNNI1 PDE3A FLT1 HEL-S-72 ACTA1 PRKAR1B KNG1 PRKAR1A PRKACG KDR BIOCARTA_NDKDYNAMIN_PATHWAY%MSIGDB_C2%BIOCARTA_NDKDYNAMIN_PATHWAY BIOCARTA_NDKDYNAMIN_PATHWAY CALM2 EPN1 PICALM HEL-S-72 NME2 SYNJ1 PPP3CA AP2A1 PPP3CC AP2M1 PID_FAK_PATHWAY%MSIGDB_C2%PID_FAK_PATHWAY PID_FAK_PATHWAY KIAA0142 RRAS MAPK1 ROCK2 YES1 NCK1 MAP2K4 SRC BRAF RAP1A ITGAV ITGB5 PTPN21 SH3GL1 ARHGAP26 KLF8 RAPGEF1 TLN1 CRK BMX CCND1 HEL114 JUN MAPK9 MAPK8IP3 PIK3R1 RAC1 ELMO1 DKFZp434N101 ACTA1 MAP2K1 FYN PIK3CA ARHGEF28 MAPK8 ASAP1 GRB2 ARHGAP35 MMP14 SOS1 NCK2 ARHGEF11 ARHA ITGB1 GIT2 RAF1 GRB7 PXN DOCK1 WASL ACTN1 DKFZp666O0110 PAK1 PID_TELOMERASE_PATHWAY%MSIGDB_C2%PID_TELOMERASE_PATHWAY PID_TELOMERASE_PATHWAY MAPK1 XRCC5 TNKS TERF1 IFNG RBBP4 BLM PINX1 SMG6 NBN PARP2 TINF2 DKC1 POT1 hCG_37731 TERF2IP WRN ACD PTGES3 ZNFX1 ATM HNRNPC HUS1 FOS IRF1 MRE11A CCND1 RAD50 RAD9A NCL IFNAR2 TERF2 JUN SMG5 NR2F2 HEL2 SAP30 TERT SIN3B MYC SIN3A SAP18 RBBP7 MTOR MAPK3 IL2 NFKB1 TGFB1 MXD1 RPS6KB1 SP1 WT1 HDAC1 MAX EGF SP3 CDKN1B UBE3A HDAC2 EGFR PID_HIV_NEF_PATHWAY%MSIGDB_C2%PID_HIV_NEF_PATHWAY PID_HIV_NEF_PATHWAY NFKBIA RELA CRADD CHUK TRADD hCG_20684 TRAF2 DKFZp686J04131 TNFRSF1A TNFSF6 RIPK1 CD247 NFKB1 MAPK8 BCL2 CASP6 hCG_16983 CASP9 CASP3 MAP3K5 BAG4 FADD TRAF1 DFFB TNF-alpha DFFA APAF1 CYCS BIRC3 PID_RANBP2_PATHWAY%MSIGDB_C2%PID_RANBP2_PATHWAY PID_RANBP2_PATHWAY RAN RANBP2 MDM2 UBE2I SUMO1 HDAC1 PIAS1 HDAC4 PIAS2 BIOCARTA_HCMV_PATHWAY%MSIGDB_C2%BIOCARTA_HCMV_PATHWAY BIOCARTA_HCMV_PATHWAY MAPK1 CREB1 MAP2K2 SP1 MAP2K3 MAPK14 PIK3R1 RB1 MAP3K1 RELA MAP2K6 MAP2K1 MAPK3 NFKB1 PIK3CA BIOCARTA_TNFR2_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR2_PATHWAY BIOCARTA_TNFR2_PATHWAY IKBKB NFKBIA MAP3K1 TNFAIP3 RELA CHUK TRAF2 DKFZp686J04131 TRAF1 TANK TNFRSF1B TRAF3 RIPK1 IKBKAP IKBKG NFKB1 BIOCARTA_PRION_PATHWAY%MSIGDB_C2%BIOCARTA_PRION_PATHWAY BIOCARTA_PRION_PATHWAY LAMC1 BCL2 HEL-S-89n DNAJB1 DNAJB6 APLP1 NFE2L2 RPSA LAMB1 PRNP LAMA1 PID_CXCR4_PATHWAY%MSIGDB_C2%PID_CXCR4_PATHWAY PID_CXCR4_PATHWAY BLK RALB YES1 HEL-S-15 MAPKAP1 c-fgr MLST8 RICTOR SRC CD3G CD3E CD3D CDC42 ITGAV CD247 CRK FOXO1 STAT5B PAG1 RGS1 RHOB UBQLN1 VPS4B VPS4A CSK SSH1 ARR3 PIK3R5 GNA13 GNG2 PTPN6 ITGA4 PIK3R3 GNB1 PIK3CD ITGA2 PIK3R2 ITGA1 PIK3R1 BAD STAT3 PRKCZ ARRB2 ITGA7 RAC1 ITGA6 LYN PTPN11 hCG_2043376 MTOR FYN GNAZ PIK3CA GNAI3 PTEN GNAI1 LCK PDPK1 PTK2B STAT2 ITCH GNAO1 ARHA PLCB3 ITGB1 PLCB1 CXCR4 PLCB2 STAT1 HLA-DRA VAV1 PXN LIMK1 HGS DKFZp666O0110 MMP9 ADRBK1 PAK1 CXCL12 PTPRC BIOCARTA_LONGEVITY_PATHWAY%MSIGDB_C2%BIOCARTA_LONGEVITY_PATHWAY BIOCARTA_LONGEVITY_PATHWAY GHR GH1 IGF1 IGF1R DKFZp564M2422 HRAS HEL-S-44 SHC1 PIK3R1 FOXO3 PIK3CA BIOCARTA_ACTINY_PATHWAY%MSIGDB_C2%BIOCARTA_ACTINY_PATHWAY BIOCARTA_ACTINY_PATHWAY NTRK1 ABI2 PIR WASF3 RAC1 WASF1 NCK1 ACTA1 WASL HEL-S-276 WASF2 NCKAP1 PID_PS1_PATHWAY%MSIGDB_C2%PID_PS1_PATHWAY PID_PS1_PATHWAY NR1C2 MAPK1 CSNK2A1 JUN RBPJ GSK3B NOTCH1 APC NEDD4 MYC MAP3K7 MAPK3 CREBBP PP2150 NLK AXIN1 PSEN1 CTBP1 DVL1 FRAT1 FZD1 CSNK1A1 MAP3K7IP1 HDAC1 FOS CCND1 CTNNB1 HNF1A PSENEN DTX1 LRP6 NKD1 APH1B WIF1 PPP2R5D DKK2 WNT1 DKK1 ADAM10 BIOCARTA_ACETAMINOPHEN_PATHWAY%MSIGDB_C2%BIOCARTA_ACETAMINOPHEN_PATHWAY BIOCARTA_ACETAMINOPHEN_PATHWAY NR1I3 PTGS2 PTGS1 CYP1A2 CYP2E1 BIOCARTA_CXCR4_PATHWAY%MSIGDB_C2%BIOCARTA_CXCR4_PATHWAY BIOCARTA_CXCR4_PATHWAY MAPK1 PTK2B HRAS PIK3R1 RELA GNAQ RAF1 CXCR4 DKFZp434N101 MAP2K1 PRKCB PIK3C2G MAPK3 NFKB1 PRKCA PIK3CA CRK CXCL12 BIOCARTA_CB1R_PATHWAY%MSIGDB_C2%BIOCARTA_CB1R_PATHWAY BIOCARTA_CB1R_PATHWAY PLD2 CNR2 CNR1 DKFZp434A091 BAAT PLD3 PID_CMYB_PATHWAY%MSIGDB_C2%PID_CMYB_PATHWAY PID_CMYB_PATHWAY MYOD1 NRAS CLTA KRAS CEBPA NCOR1 hCG_1991735 DKFZp586H0919 CREBBP CEBPB HES1 CEBPD CDKN2A ADA NLK ELANE KITLG KIT CCND1 SPI1 LECT2 YEATS4 RAG2 CD34 PPP3CA HEL-S-72p PAX5 CCNB1 SND1 ADORA2B TFEC PRTN3 PIM1 MAD1L1 HEL-S-11 DKFZp686J11229 UBE2I H2AZ1 ZFHX3 GSTM1 CBX4 ATP2B1 LYZ HIPK2 CSF1R SKI MYF6 ETS2 MYC SIN3A MYB ZFPM1 CDK6 GATA1 MAP3K7 COPA GATA3 BCL2 CASP6 HRAS MAP3K7IP1 SP1 PTGS2 CDKN1A COL1A2 CDKN1B MPO TRIM28 EP300 WNT1 BIRC3 BIOCARTA_PRC2_PATHWAY%MSIGDB_C2%BIOCARTA_PRC2_PATHWAY BIOCARTA_PRC2_PATHWAY BMI1 HDAC1 CBX4 SUZ12 RBBP4 EED DKFZp686A1782 COMMD3-BMI1 EZH1 HDAC2 YY1 EZH2 RBBP7 PID_S1P_S1P2_PATHWAY%MSIGDB_C2%PID_S1P_S1P2_PATHWAY PID_S1P_S1P2_PATHWAY GNA15 GNA11 MAPK1 JUN MAPK14 FOS GNAO1 ARHA GNAQ EDG5 RAC1 IRS1 MAPK3 GNAZ GNA13 GNAI3 GNAI1 GNA14 PAK1 MAPK8 BIOCARTA_INFLAM_PATHWAY%MSIGDB_C2%BIOCARTA_INFLAM_PATHWAY BIOCARTA_INFLAM_PATHWAY IL4 IL3 IL7 IL6 IL5 IFNG IL11 CSF1 PDGFA CSF3 CSF2 IL2 TGFB1 IL1A HLA-DRB5 HLA-DRB4 HLA-DRA HLA-DRB3 HLA-DRB1 IL8 TNF-alpha IL10 IFNA1 IL15 IFNB1 IL13 BIOCARTA_PLC_PATHWAY%MSIGDB_C2%BIOCARTA_PLC_PATHWAY BIOCARTA_PLC_PATHWAY PLCB1 VAV1 DKFZp434N101 PRKCB PIK3R1 PIK3CA PRKCA BIOCARTA_IGF1R_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1R_PATHWAY BIOCARTA_IGF1R_PATHWAY IGF1R GRB2 MAPK1 SOS1 HRAS SHC1 PIK3R1 BAD ADCY1 RAF1 IRS1 MAP2K1 PRKAR1B MAPK3 PRKAR1A PIK3CA PRKACG RPS6KA1 PID_IL12_STAT4_PATHWAY%MSIGDB_C2%PID_IL12_STAT4_PATHWAY PID_IL12_STAT4_PATHWAY IFNG JUN MAPK9 STAT3 IL18RAP PIAS2 CD3G PPP3R1 PRF1 CD3E CD3D TBX21 CD247 CREBBP IL2 TGFB1 MAPK8 IL2RA STAT4 FOS IRF1 IL18R1 ETV5 CD80 HLA-DRA IL13 PPP3CA IL18 BIOCARTA_TERC_PATHWAY%MSIGDB_C2%BIOCARTA_TERC_PATHWAY BIOCARTA_TERC_PATHWAY NFYA SP1 NFYB NFYC SP3 RB1 BIOCARTA_SLRP_PATHWAY%MSIGDB_C2%BIOCARTA_SLRP_PATHWAY BIOCARTA_SLRP_PATHWAY DCN DSPG3 KERA PID_SMAD2_3NUCLEAR_PATHWAY%MSIGDB_C2%PID_SMAD2_3NUCLEAR_PATHWAY PID_SMAD2_3NUCLEAR_PATHWAY MYOD1 KAT2B KAT2A IL5 CREB1 RBL1 NR1i1 TFDP1 IRF7 RBBP4 NCOR1 E2F4 E2F5 ITGB5 RUNX1 CREBBP CEBPB FOXO4 NR3C1 FOXO1 NR2A1 CDK2 FOS ATF3 CBFB HEL-S-72p RUNX2 NCOA1 JUN GSC FOXO3 SKI SAP30 SIN3B MYC SIN3A SAP18 SKIL RBBP7 CITED1 MED15 SNIP1 TGIF1 SMAD2 TGIF2 SMAD4 FOXH1 RUNX3 DLX1 FOXG1 LAMC1 GATA3 CDKN2B DCP1A CTBP1 SP1 HDAC1 MAX SP3 ATF2 CDKN1A COL1A2 SERPINE1 HDAC2 NKX2-5 EP300 MEF2C CDK4 IL10 TCF3 IFNB1 PID_INTEGRIN_CS_PATHWAY%MSIGDB_C2%PID_INTEGRIN_CS_PATHWAY PID_INTEGRIN_CS_PATHWAY ITGAE ITGB8 ITGB7 ITGA4 ITGB6 ITGA2 ITGA1 ITGB1 ITGB3 ITGA2B ITGA7 ITGA6 ITGAX ITGAV ITGAM ITGB5 ITGB4 BIOCARTA_P53HYPOXIA_PATHWAY%MSIGDB_C2%BIOCARTA_P53HYPOXIA_PATHWAY BIOCARTA_P53HYPOXIA_PATHWAY NQO1 FHL2 ATM NFKBIB RPA1 DNAJB1 GADD45A TAF1 CDKN1A BAX ABCB1 HIF1A MDM2 EP300 HIC1 MAPK8 PID_HEDGEHOG_GLI_PATHWAY%MSIGDB_C2%PID_HEDGEHOG_GLI_PATHWAY PID_HEDGEHOG_GLI_PATHWAY GNB1 SMO GSK3B RBBP4 SAP30 ARRB2 SIN3B SIN3A SAP18 CSNK1G3 RBBP7 CSNK1D MAP2K1 CSNK1G2 CREBBP CSNK1G1 GNAZ GNAI3 GNAI1 CSNK1A1 CSNK1E IFT172 HDAC1 GLI3 SHH PIAS1 KIF3A GNAO1 SUFU PTCH1 RAB23 SPOP hCG_22119 MTSS1 HDAC2 FOXA2 GNG2 BIOCARTA_BBCELL_PATHWAY%MSIGDB_C2%BIOCARTA_BBCELL_PATHWAY BIOCARTA_BBCELL_PATHWAY HLA-DRB4 HLA-DRA HLA-DRB3 TNFSF6 HLA-DRB1 CD40 CD40LG HLA-DRB5 PID_REG_GR_PATHWAY%MSIGDB_C2%PID_REG_GR_PATHWAY PID_REG_GR_PATHWAY IL4 IL6 PPP5C MAPK1 IL5 CREB1 IFNG MAPK11 SMARCD1 GSK3B SMARCC1 SGK1 SMARCC2 TSG101 TBP BAX KRT5 CSF2 CREBBP PRKACG KRT14 NR3C1 POU2F1 STAT5B FOS IRF1 NR1I3 SELE POMC SPI1 NFATC1 SFN NCOA1 BGLAP JUN PRL MAPK9 MAPK14 SUMO2 RELA MAPK10 SMARCA4 TBX21 MDM2 MAPK3 IL2 NFKB1 MAPK8 GATA3 CDK5 HDAC1 CDK5R1 CDKN1A CSN2 POU1F1 FKBP4 FKBP5 CGA STAT1 PCK2 HDAC2 PBX1 IL8 EP300 AFP IL13 EGR1 PID_RAC1_PATHWAY%MSIGDB_C2%PID_RAC1_PATHWAY PID_RAC1_PATHWAY ARPC1B ACTR3 ACTR2 IQGAP3 PIP5K1A HEL-S-15 JUN HEL-S-47e MAPK9 MAP2K3 MAPK14 MAP2K4 STAT3 MAP3K1 ARPC4 BAIAP2 ARPC2 ARPC3 RAC1 CTNNA1 WASF1 PIP5K1C hCG_1991735 MAP2K6 CRK MAPK8 ARHGAP5 MAP3K11 CTNNB1 ATF2 STM7 ABI2 PLCB2 NCF1 NCF2 CYBB BRK1 LIMK1 CYBA NOXA1 CYFIP2 WASF2 NCKAP1 PAK1 BIOCARTA_G1_PATHWAY%MSIGDB_C2%BIOCARTA_G1_PATHWAY BIOCARTA_G1_PATHWAY CDKN2B CDC2 DHFR TFDP1 CDK2 ATM HDAC1 CCNE1 CCND1 RB1 GSK3B CDKN1A CDKN1B CDK6 SKP2 CDK4 ATR SMAD4 TGFB1 CDKN2A BIOCARTA_KERATINOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_KERATINOCYTE_PATHWAY BIOCARTA_KERATINOCYTE_PATHWAY MAPK1 JUN PRKCE MAP2K3 MAPK14 IKBKB MAP2K4 NFKBIA MAP3K1 CEBPA RELA CHUK ETS2 TRAF2 DKFZp686J04131 PPP2CA MAPK13 TNFRSF1A TNFSF6 RIPK1 MAP2K6 MAP2K1 MAPK3 NFKB1 MAPK8 BCL2 HRAS PRKCH SP1 FOS EGF MAP3K5 PRKCQ RAF1 TNFRSF1B TNF-alpha PRKCB HOXA7 PRKCA EGFR BIOCARTA_CARM_ER_PATHWAY%MSIGDB_C2%BIOCARTA_CARM_ER_PATHWAY BIOCARTA_CARM_ER_PATHWAY SRA1 NR0B1 PHB2 NCOR2 GRIP1 MED1 HDAC3 SPEN HDAC1 PPARGC1A HDAC4 DKFZp566E044 CCND1 HDAC5 GTF2A1 CARM1 TBP BRCA1 HDAC2 PELP1 MEF2C EP300 CREBBP H3C15 BIOCARTA_AKAP13_PATHWAY%MSIGDB_C2%BIOCARTA_AKAP13_PATHWAY BIOCARTA_AKAP13_PATHWAY PRKAG1 ARHA PRKACG LPAR3 EDG2 EDG4 PID_MAPK_TRK_PATHWAY%MSIGDB_C2%PID_MAPK_TRK_PATHWAY PID_MAPK_TRK_PATHWAY NRAS MAP3K2 RPS6KA5 MAPK1 CREB1 MAP2K3 MAPK14 KRAS BRAF TRPV1 RAP1A MAP2K6 MAP2K1 MAPK3 CDK5 HRAS FOS CDK5R1 NTF3 RAF1 RIT1 MAPKAPK2 RIT2 MEF2C MAPK7 RPS6KA1 MAP2K5 EGR1 PID_LYSOPHOSPHOLIPID_PATHWAY%MSIGDB_C2%PID_LYSOPHOSPHOLIPID_PATHWAY PID_LYSOPHOSPHOLIPID_PATHWAY IL6 SLC9A3R2 TIAM1 ADCY9 PRKCE ADCY3 LPAR4 ADCY1 ADCY8 GSK3B ADCY6 SRC CRK FOS GNA13 GNG2 TRIP6 PLD2 GNB1 ARHGEF1 JUN PIK3R1 NFKBIA RELA PRKD1 RAC1 HBEGF LYN DKFZp434N101 GNAZ NFKB1 GNAI3 GNAI1 GNA14 GNA15 GNA11 PTK2B HRAS GNAO1 ARHA MMP2 PLCB3 GNAQ CASP3 ADRA1B IL8 PXN LPAR3 DKFZp666O0110 EDG2 EDG4 MMP9 EGFR PID_P38_MKK3_6PATHWAY%MSIGDB_C2%PID_P38_MKK3_6PATHWAY PID_P38_MKK3_6PATHWAY TAOK2 MAP3K7IP1 ATM MAP2K3 MAPK14 GADD45A MAPK11 MAP3K1 TRAF6 MAP3K6 TXN MAP3K5 TRAF2 MAP3K10 GADD45B RAC1 GADD45G MAP3K7 MAP2K6 TAOK3 BIOCARTA_NO2IL12_PATHWAY%MSIGDB_C2%BIOCARTA_NO2IL12_PATHWAY BIOCARTA_NO2IL12_PATHWAY CD3E CD3D CD2 IFNG CD247 TYK2 STAT4 NOS2 CXCR3 IL12RB1 CCR5 CD3G BIOCARTA_RACC_PATHWAY%MSIGDB_C2%BIOCARTA_RACC_PATHWAY BIOCARTA_RACC_PATHWAY GUCY1A2 TRPC5 GUCY1B1 TRPC4 TRPV4 KCNQ2 KCNQ3 KCNQ5 ADCY1 TRPC3 GNAS BIOCARTA_EIF2_PATHWAY%MSIGDB_C2%BIOCARTA_EIF2_PATHWAY BIOCARTA_EIF2_PATHWAY EIF2B5 EIF2AK2 EIF2S2 EIF5 DKFZp781H1925 EIF2AK1 EIF2S1 GSK3B EIF2S3 EIF2AK4 BIOCARTA_MITOCHONDRIA_PATHWAY%MSIGDB_C2%BIOCARTA_MITOCHONDRIA_PATHWAY BIOCARTA_MITOCHONDRIA_PATHWAY BCL2 AIFM1 BAK1 CASP6 hCG_16983 DIABLO BIK CASP9 CASP3 BAX DFFB DFFA APAF1 BIRC2 BIRC3 PID_IL2_1PATHWAY%MSIGDB_C2%PID_IL2_1PATHWAY PID_IL2_1PATHWAY NRAS MAPK1 IFNG PRKCE MAPK11 KRAS STAM2 SOCS2 CISH STAT5B CDK2 FOS IKZF3 PPP2R5D IRS1 PRKCB SOCS3 SYK SOCS1 JUN SHC1 MAPK9 MAPK14 PIK3R1 IL2RG STAT3 MYC JAK3 JAK1 PTPN11 GAB2 MAP2K1 FYN MAPK3 IL2 PIK3CA LCK MAPK8 IL2RA IL2RB BCL2 GRB2 SOS1 PTK2B MAP2K2 HRAS ARHA RAF1 STAT1 MAPKAPK2 PID_RHOA_PATHWAY%MSIGDB_C2%PID_RHOA_PATHWAY PID_RHOA_PATHWAY PLD2 ROCK2 PIP5K1A HEL-S-15 JUN MAP2K3 DKFZp686M02159 MAP2K4 PRKCZ LIMK2 SCAI HEL70 CDC42 RDX PARD6A MRTFA CIT PKN2 PIP5K1C MAP2K6 ACTA1 TLN1 PTEN MYL2 MAPK8 EZR PKN1 F2RL2 FOS ARHA SLC9A3 ITGB1 ATF2 HEL114 CDKN1B STM7 ROCK1 LIMK1 DKFZp686B23205 PID_BARD1_PATHWAY%MSIGDB_C2%PID_BARD1_PATHWAY PID_BARD1_PATHWAY UBE2L3 XRCC5 CCNE1 UBE2D3 CSTF1 RBBP8 BARD1 EWSR1 NBN RAD51 FANCL CDK2 FANCA ATM MRE11A FANCC FANCE FANCG FANCF RAD50 FANCD2 BRCA1 PCNA ATR PRKDC TOPBP1 BIOCARTA_BARD1_PATHWAY%MSIGDB_C2%BIOCARTA_BARD1_PATHWAY BIOCARTA_BARD1_PATHWAY FANCD2 BRCA1 BARD1 FANCA FANCC FANCE FANCG FANCF PID_SYNDECAN_2_PATHWAY%MSIGDB_C2%PID_SYNDECAN_2_PATHWAY PID_SYNDECAN_2_PATHWAY TACI MAPK1 EPHB2 ITGA2 SRC BAX CSF2 CAV2 TRAPPC4 MAPK3 TGFB1 MAPK8 EZR HRAS ARHA MMP2 ITGB1 LAMA1 LAMA3 CASP3 CASK NF1 IL8 SDCBP KNG1 SDC2 BIOCARTA_NFAT_PATHWAY%MSIGDB_C2%BIOCARTA_NFAT_PATHWAY BIOCARTA_NFAT_PATHWAY CAMK1 MAPK1 CALM2 CAMK1G MAPK14 PIK3R1 GSK3B NFATC4 HBEGF CAMK4 ACTA1 NPPA MAP2K1 PRKAR1B CTF1 MAPK3 CREBBP HEL-S-99n PRKAR1A PRKACG PIK3CA HAND2 RPS6KB1 HAND1 MAPK8 MYH2 IGF1 HRAS CSNK1A1 EDN1 NFATC3 RAF1 GATA4 FGF2 NKX2-5 MEF2C HEL-S-72 NFATC2 NFATC1 PPP3CA PPP3CC BIOCARTA_DNAFRAGMENT_PATHWAY%MSIGDB_C2%BIOCARTA_DNAFRAGMENT_PATHWAY BIOCARTA_DNAFRAGMENT_PATHWAY DFFB DFFA HMGB2 TOP2A HMGB1 CASP3 BIOCARTA_ION_PATHWAY%MSIGDB_C2%BIOCARTA_ION_PATHWAY BIOCARTA_ION_PATHWAY PTK2B DKFZp434N101 PRKCB PRKCA P2RY2 BIOCARTA_TNFR1_PATHWAY%MSIGDB_C2%BIOCARTA_TNFR1_PATHWAY BIOCARTA_TNFR1_PATHWAY JUN MAP2K4 MAP3K1 CRADD TRADD hCG_20684 TRAF2 TNFRSF1A RIPK1 MAP3K7 MAPK8 hCG_16983 RB1 LMNB2 CASP3 BAG4 FADD LMNA ARHGDIB DFFB TNF-alpha DFFA PARP1 PRKDC MADD PAK1 PID_P75_NTR_PATHWAY%MSIGDB_C2%PID_P75_NTR_PATHWAY PID_P75_NTR_PATHWAY NGFR NGF HEL-S-47e TRAF6 CHUK NTRK1 BCL2L11 IKBKG NSMCE3 OMG RTN4R MAGEH1 BEX3 ZNF274 BEX1 RTN4 NDN SORT1 RHOB PSENEN FURIN APH1B RIPK2 SHC1 MAPK9 IKBKB PIK3R1 BAD HEL2 PRKCZ ADAM17 MAPK10 IRAK1 RAC1 MYD88 hCG_2043376 PIK3CA MAPK8 PSEN1 PRKCI CASP6 ARHA DIABLO CASP9 MAGED1 SMPD2 CASP3 NTF5 NTF3 PLG MMP7 SQSTM1 BDNF MMP3 APP APAF1 CYCS BIRC2 BIRC3 BIOCARTA_RANMS_PATHWAY%MSIGDB_C2%BIOCARTA_RANMS_PATHWAY BIOCARTA_RANMS_PATHWAY RAN RCC1 HCTP4 RANBP1 KPNA2 KIF15 NUMA1 AURKA PID_ANTHRAX_PATHWAY%MSIGDB_C2%PID_ANTHRAX_PATHWAY PID_ANTHRAX_PATHWAY VCAM1 MAPK1 MAP2K2 MAP2K3 PGR MAP2K4 ANTXR2 ANTXR1 NLRP1 DEFA1B IL1B TNF-alpha MAP2K6 MAP2K1 MAPK3 IL18 PID_ECADHERIN_NASCENT_AJ_PATHWAY%MSIGDB_C2%PID_ECADHERIN_NASCENT_AJ_PATHWAY PID_ECADHERIN_NASCENT_AJ_PATHWAY CSNK2A1 TIAM1 CSNK2A2 PIK3R1 CSNK2B SRC CDC42 RAP1A RAC1 CTNNA1 PIP5K1C hCG_1991735 ARF6 VAV2 AFDN JUP RAPGEF1 PIK3CA CRK ITGAE ITGB7 DKFZp686A1195 ARHA CCND1 CTNNB1 KLHL20 CTNND1 CYFIP2 WASF2 NCKAP1 BIOCARTA_IL5_PATHWAY%MSIGDB_C2%BIOCARTA_IL5_PATHWAY BIOCARTA_IL5_PATHWAY IL4 HLA-DRB4 IL6 CCL11 HLA-DRA IL5 IL5RA HLA-DRB3 HLA-DRB1 IL1B CCR3 HLA-DRB5 PID_UPA_UPAR_PATHWAY%MSIGDB_C2%PID_UPA_UPAR_PATHWAY PID_UPA_UPAR_PATHWAY SRC ITGB3 VTN RAC1 ITGAV ITGAM ITGB5 TGFB1 CRK VLDLR PLAUR ELANE GPLD1 FGA ITGB1 FPR1 KLK4 SERPINE1 PDGFD PLG CTSG HEL-S-78p FPRL1 HGF FPRL2 MMP12 CTRC NCL MMP3 DOCK1 EGFR MMP9 BIOCARTA_IFNG_PATHWAY%MSIGDB_C2%BIOCARTA_IFNG_PATHWAY BIOCARTA_IFNG_PATHWAY IFNGR1 IFNGR2 STAT1 IFNG JAK1 PID_VEGFR1_2_PATHWAY%MSIGDB_C2%PID_VEGFR1_2_PATHWAY PID_VEGFR1_2_PATHWAY MAPK1 ARF1 NCK1 MAP2K3 MAPK11 SRC BRAF ITGB3 CDC42 CTNNA1 FLT1 ITGAV hCG_1991735 MAP2K6 KDR FES HEL114 HSP90AB1 PRKAB1 MYOF PRKCB PRKCA VEGFA PTPN6 MAPK14 PIK3R1 NEDD4 GRB10 VTN PRKAG1 PTPN11 DKFZp434N101 MAP2K1 FYN MAPK3 SHB PIK3CA PDPK1 CBL GRB2 PTK2B MAP2K2 NCK2 PRKAA1 ARHA PRKAA2 CTNNB1 RAF1 MAPKAPK2 ROCK1 PXN HGS DKFZp666O0110 SH2D2A CAMKK2 PID_ARF6_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_ARF6_DOWNSTREAM_PATHWAY PID_ARF6_DOWNSTREAM_PATHWAY PLD2 MAPK1 RAB11A TIAM1 PIP5K1A ARF1 ARHA RAC1 ARF6 RAB11FIP3 MAPK3 KALRN PLAUR BIOCARTA_ERBB3_PATHWAY%MSIGDB_C2%BIOCARTA_ERBB3_PATHWAY BIOCARTA_ERBB3_PATHWAY ERBB3 EGF UBE2D1 NRG1 EGFR BIOCARTA_MELANOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_MELANOCYTE_PATHWAY BIOCARTA_MELANOCYTE_PATHWAY BCL2 KITLG CREB1 KIT EP300 MITF-C RPS6KA1 BIOCARTA_GSK3_PATHWAY%MSIGDB_C2%BIOCARTA_GSK3_PATHWAY BIOCARTA_GSK3_PATHWAY AXIN1 DVL1 EIF2AK2 FZD1 PIK3R1 CCND1 CTNNB1 GSK3B RELA APC PPP2CA CXNK2 WNT1 MYD88 DKFZp586H0919 NFKB1 LBP PIK3CA PDPK1 BIOCARTA_EGFR_SMRTE_PATHWAY%MSIGDB_C2%BIOCARTA_EGFR_SMRTE_PATHWAY BIOCARTA_EGFR_SMRTE_PATHWAY NCOR2 RXRA RARA MAPK14 MAP2K1 EGF MAP3K1 ZBTB16 THRB THRA EGFR BIOCARTA_PITX2_PATHWAY%MSIGDB_C2%BIOCARTA_PITX2_PATHWAY BIOCARTA_PITX2_PATHWAY AXIN1 DVL1 FZD1 MED1 HDAC1 CTNNB1 GSK3B APC TRRAP EP300 WNT1 HTATIP DKFZp586H0919 CREBBP LDB1 PITX2 BIOCARTA_IL17_PATHWAY%MSIGDB_C2%BIOCARTA_IL17_PATHWAY BIOCARTA_IL17_PATHWAY IL3 IL6 KITLG IL17A CD3G CD3E CD3D CSF3 CD2 IL8 CD247 CD8A CD34 CD58 BIOCARTA_FMLP_PATHWAY%MSIGDB_C2%BIOCARTA_FMLP_PATHWAY BIOCARTA_FMLP_PATHWAY CAMK1 MAPK1 CALM2 CAMK1G MAP2K3 MAPK14 NFKBIA MAP3K1 RELA NFATC4 RAC1 MAP2K6 MAP2K1 MAPK3 NFKB1 GNA15 MAP2K2 HRAS NFATC3 FPR1 RAF1 PLCB1 NCF1 NCF2 HEL-S-72 PIK3C2G NFATC2 NFATC1 PPP3CA PAK1 PPP3CC BIOCARTA_PS1_PATHWAY%MSIGDB_C2%BIOCARTA_PS1_PATHWAY BIOCARTA_PS1_PATHWAY AXIN1 PSEN1 DVL1 DKFZp781N011 FZD1 RBPJ CTNNB1 GSK3B NOTCH1 HNF1A ADAM17 APC WNT1 BIOCARTA_EOSINOPHILS_PATHWAY%MSIGDB_C2%BIOCARTA_EOSINOPHILS_PATHWAY BIOCARTA_EOSINOPHILS_PATHWAY HLA-DRB4 IL3 CCL11 HLA-DRA IL5 HLA-DRB3 HLA-DRB1 CCR3 CSF2 CCL5 HLA-DRB5 PID_VEGF_VEGFR_PATHWAY%MSIGDB_C2%PID_VEGF_VEGFR_PATHWAY PID_VEGF_VEGFR_PATHWAY VEGFA NRP1 FLT4 VEGFB VEGFC VEGFD DKFZp686J1169 FLT1 KDR BIOCARTA_VOBESITY_PATHWAY%MSIGDB_C2%BIOCARTA_VOBESITY_PATHWAY BIOCARTA_VOBESITY_PATHWAY RETN NR3C1 RXRA TNF-alpha LPL PPARG HSD11B1 BIOCARTA_MPR_PATHWAY%MSIGDB_C2%BIOCARTA_MPR_PATHWAY BIOCARTA_MPR_PATHWAY CAP1 CDC2 PAQR7 PAQR5 MAPK1 HRAS PGR ADCY1 PIN1 ACTA1 PRKAR1B MYT1 MAPK3 PRKAR1A PRKACG CCNB1 RPS6KA1 BIOCARTA_RAC1_PATHWAY%MSIGDB_C2%BIOCARTA_RAC1_PATHWAY BIOCARTA_RAC1_PATHWAY CDK5 PIK3R1 CDK5R1 MAP3K1 PPP1R12B RAC1 WASF1 VAV1 NCF2 LIMK1 PDGFRA CHN1 RALBP1 TRIO PIK3CA RPS6KB1 MYL2 PAK1 PID_SYNDECAN_1_PATHWAY%MSIGDB_C2%PID_SYNDECAN_1_PATHWAY PID_SYNDECAN_1_PATHWAY COL4A6 COL4A5 MAPK1 hEMMPRIN HPSE PPIB COL1A1 SDC1 COL16A1 COL14A1 COL12A1 MAPK3 COL17A1 COL10A1 LAMA5 TGFB1 COL2A1 COL6A1 COL8A2 COL8A1 COL13A1 COL11A2 COL5A2 COL9A1 COL9A3 COL9A2 COL3A1 COL1A2 CASK HGF SDCBP MMP7 CCL5 COL4A1 MMP9 COL4A4 COL4A3 BIOCARTA_D4GDI_PATHWAY%MSIGDB_C2%BIOCARTA_D4GDI_PATHWAY BIOCARTA_D4GDI_PATHWAY PRF1 CASP10 ARHGAP5 ARHGDIB JUN PARP1 hCG_16983 APAF1 CASP9 CASP3 PID_IL6_7_PATHWAY%MSIGDB_C2%PID_IL6_7_PATHWAY PID_IL6_7_PATHWAY IL6 SOCS3 TNFSF11 LMO4 CRP JUN HEL-S-125m MITF-C MAPK14 PIK3R1 A2M MAP2K4 PTPRE MAPK11 STAT3 MYC RAC1 JAK1 MAP2K6 PTPN11 MCL1 GAB2 CEBPB PIK3CA CEBPD FOXO1 GRB2 SOS1 TIMP1 IL6ST BCL2L1 IL6R TYK2 PIAS1 FOS IRF1 JUNB STAT1 VAV1 LBP BIOCARTA_REELIN_PATHWAY%MSIGDB_C2%BIOCARTA_REELIN_PATHWAY BIOCARTA_REELIN_PATHWAY LRP8 DAB1 RELN CDK5 FYN CDK5R1 VLDLR PID_ATF2_PATHWAY%MSIGDB_C2%PID_ATF2_PATHWAY PID_ATF2_PATHWAY CCNA2 IL6 MAPK1 CREB1 IFNG DUSP8 TH MAPK11 DUSP10 RUVBL2 HTATIP HES1 POU2F1 FOS CCND1 JUNB JUND SELE NF1 NOS2 ATF3 ARG1 PRKCA CBFB INS SOCS3 JUN MAPK9 MAPK14 PPARGC1A GADD45A HRK ACHE CSRP2 JDP2 MACROH2A1 COL24A1 HBG2 PDGFRA MAPK3 MAPK8 BCL2 BCL2L1 DUSP5 MMP2 RB1 ATF2 SERPINB5 IL23A BRCA1 DDIT3 IL8 EP300 CDK4 PID_NFAT_3PATHWAY%MSIGDB_C2%PID_NFAT_3PATHWAY PID_NFAT_3PATHWAY RAN MEF2D SFN PIM1 NUP214 CSNK2A1 PRKCE MAPK9 MAPK14 KPNA2 BAD HEL2 RCAN1 GSK3B PRKCZ MAP3K8 MAP3K1 PPP3R1 CAMK4 MAPK3 CREBBP MAPK8 BCL2 YWHAQ FKBP1A HEL-S-1 BCL2L1 PRKCH CSNK1A1 YWHAG NFATC3 YWHAZ CASP3 PRKCQ EP300 AKAP5 CHP1 PRKCB NFATC2 NFATC1 PRKCA CABIN1 PPP3CA BIOCARTA_AKAPCENTROSOME_PATHWAY%MSIGDB_C2%BIOCARTA_AKAPCENTROSOME_PATHWAY BIOCARTA_AKAPCENTROSOME_PATHWAY CDC2 PPP2CA NUP85 AKAP9 PCNT PRKAG1 PRKCE PKN1 ARHA PRKACG MAP2 BIOCARTA_ACH_PATHWAY%MSIGDB_C2%BIOCARTA_ACH_PATHWAY BIOCARTA_ACH_PATHWAY TNFSF6 PTK2B CHRNB1 MUSK CHRNG RAPSN PIK3R1 BAD FOXO3 PIK3CA TERT PID_NOTCH_PATHWAY%MSIGDB_C2%PID_NOTCH_PATHWAY PID_NOTCH_PATHWAY IL4 MAML2 ADAM12 KDM1A MAML1 RAB11A NCOR2 SPEN RBPJ NOTCH1 FBXW7 RBBP8 MYC NCOR1 SKP2 NOTCH3 MYCBP DLL3 DLL4 DNER JAG2 MIB1 GATA3 CBL MFAP5 PSEN1 MFAP2 CTBP1 LNX1 CNTN1 ITCH HDAC1 CCND1 CDKN1A PSENEN SKP1 FURIN DTX1 HEL-S-17 YY1 APH1B EP300 DKFZp434N181 ADAM10 NUMB PID_BMP_PATHWAY%MSIGDB_C2%PID_BMP_PATHWAY PID_BMP_PATHWAY MAPK1 NUP214 PPP1R15A GSK3B SKI MAP3K7 SMAD4 SMURF2 SMURF1 CHRDL1 SOSTDC1 CER1 MAP3K7IP1 AHSG CTDSP1 FST ZFYVE16 CTDSP2 CTDSPL HFE2 RGMB BAMBI SMAD1 BMP6 BMPR2 RGMA GREM1 DKFZp781O1323 SMAD9 BMP7 NOG SMAD6 BMP4 BMP2 BMPR1A PID_CD8_TCR_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_CD8_TCR_DOWNSTREAM_PATHWAY PID_CD8_TCR_DOWNSTREAM_PATHWAY NRAS MAPK1 IFNG PRKCE KRAS BRAF CD3G CD3E CD3D CD247 TNFRSF9 FOS STAT4 CD8B1 NFATC3 JUNB PRKCB NFATC2 NFATC1 PRKCA PPP3CA IFNAR2 IFNAR1 JUN MAPK9 IL2RG PPP3R1 PRF1 HLA-A B2M TNFSF6 MAP2K1 MAPK3 IL2 FOSL1 MAPK8 IL2RA IL2RB MAP2K2 HRAS IFNA5 IFNA4 PRKCQ IFNA7 RAF1 IFNA6 IFNA2 IFNA8 TNFRSF4 IFNA14 TNF-alpha IFNA16 TNFRSF18 IFNA17 IFNA10 IFNA1 IFNA21 EGR4 CD8A EGR1 PID_PTP1B_PATHWAY%MSIGDB_C2%PID_PTP1B_PATHWAY PID_PTP1B_PATHWAY INS LEP BLK SOCS3 YES1 SHC1 PRL PIK3R1 c-fgr STAT3 PRLR CSF1R SRC CSF1 ITGB3 LAT LEPR Pe1Fe6 CDH2 LYN INSR FYN PTPN1 PIK3CA CRK LCK GRB2 STAT5B TYK2 ARHA EGF CSN2 TXN CSK ITGA2B DOK1 FCGR2A IRS1 SPRY2 YBX1 EGFR BIOCARTA_EXTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_EXTRINSIC_PATHWAY BIOCARTA_EXTRINSIC_PATHWAY HEL-S-78p TFPI PROC PROS1 F7 F2R FGA F10 F3 F5 SERPINC1 PID_NFAT_TFPATHWAY%MSIGDB_C2%PID_NFAT_TFPATHWAY PID_NFAT_TFPATHWAY SLC3A2 IL4 IRF4 PTPRK IL3 IKZF1 GBP3 IL5 RNF128 IFNG JUN PPARG EGR2 CD40LG TBX21 FOXP3 TNFSF6 CSF2 PTPN1 IL2 FOSL1 IL2RA GATA3 CTLA4 POU2F1 ITCH FOS PTGS2 NFATC3 CASP3 PRKCQ JUNB IL8 TNF-alpha CDK4 BATF3 NFATC2 EGR4 NFATC1 DGKA EGR1 BIOCARTA_STEM_PATHWAY%MSIGDB_C2%BIOCARTA_STEM_PATHWAY BIOCARTA_STEM_PATHWAY IL4 IL3 IL7 IL6 IL5 IL9 IL11 CSF1 CSF3 IL8 CSF2 IL2 CD8A EPO BIOCARTA_MITR_PATHWAY%MSIGDB_C2%BIOCARTA_MITR_PATHWAY BIOCARTA_MITR_PATHWAY MYOD1 CAMK1 CAMK1G HDAC9 PID_TCPTP_PATHWAY%MSIGDB_C2%PID_TCPTP_PATHWAY PID_TCPTP_PATHWAY VEGFA INS EIF2AK2 PIK3R3 LMAN1 PIK3CD PIK3R2 STAT6 SHC1 ITGA1 PIK3R1 KPNA2 STAT3 CSF1R SRC CSF1 JAK3 JAK1 INSR PTPN1 CREBBP PIK3CA KDR GRB2 STAT5B SOS1 RAB4A PIAS1 EGF ITGB1 STAT1 HGF ATR EGFR BIOCARTA_PELP1_PATHWAY%MSIGDB_C2%BIOCARTA_PELP1_PATHWAY BIOCARTA_PELP1_PATHWAY MAPK1 PELP1 EP300 CREBBP MAPK3 BIOCARTA_BLYMPHOCYTE_PATHWAY%MSIGDB_C2%BIOCARTA_BLYMPHOCYTE_PATHWAY BIOCARTA_BLYMPHOCYTE_PATHWAY HLA-DRB4 CD80 HLA-DRA HLA-DRB3 HLA-DRB1 FCGR2B CR2 CR1 CD40 HLA-DRB5 PTPRC BIOCARTA_PDZS_PATHWAY%MSIGDB_C2%BIOCARTA_PDZS_PATHWAY BIOCARTA_PDZS_PATHWAY CASK SPTBN1 ACTA1 PCLO DLG2 GUK1 NRXN3 NCAM1 GRIN1 ADD1 DLG4 BIOCARTA_MAL_PATHWAY%MSIGDB_C2%BIOCARTA_MAL_PATHWAY BIOCARTA_MAL_PATHWAY MAPK1 MAP2K2 HRAS ARHA MAP4K2 MAP3K1 HNF1A MAL RAF1 CDC42 RAC1 ROCK1 LIMK1 ACTA1 MAP2K1 MAPK3 MAPK8 BIOCARTA_IL22BP_PATHWAY%MSIGDB_C2%BIOCARTA_IL22BP_PATHWAY BIOCARTA_IL22BP_PATHWAY STAT1 STAT5B JAK3 SOCS3 JAK1 TYK2 STAT3 BIOCARTA_CIRCADIAN_PATHWAY%MSIGDB_C2%BIOCARTA_CIRCADIAN_PATHWAY BIOCARTA_CIRCADIAN_PATHWAY CSNK1E PER1 CRY2 CRY1 BIOCARTA_LYM_PATHWAY%MSIGDB_C2%BIOCARTA_LYM_PATHWAY BIOCARTA_LYM_PATHWAY VCAM1 IL8 ITGA4 SELL PECAM1 ICAM2 ITGB1 CD34 IL1A MADCAM1 PID_EPO_PATHWAY%MSIGDB_C2%PID_EPO_PATHWAY PID_EPO_PATHWAY PTPN6 SOCS3 SHC1 MAPK14 PIK3R1 BTK SH2B3 TEC RAP1A PLCG2 LYN PTPN11 DKFZp434N101 VAV2 NFKB1 RAPGEF1 CRKL EPO MAPK8 EPOR CBL BCL2 GRB2 STAT5B SOS1 BCL2L1 HRAS TRPC6 STAT1 PID_P53_REGULATION_PATHWAY%MSIGDB_C2%PID_P53_REGULATION_PATHWAY PID_P53_REGULATION_PATHWAY CCNA2 KAT2B GSK3B RFWD2 CCNG1 RPL5 DYRK2 SETD8 SETD7 CSNK1G3 PIN1 TP53AIP1 SKP2 CSNK1D RASSF1 HTATIP PPP1R13L CHEK1 KAT8 CSNK1G2 RPL23 CSNK1G1 CREBBP FBXO11 PPM1D PTPA SMYD2 CDKN2A E4F1 MDM4 CDK2 CSNK1E CSNK1A1 ATM NEDD8 ATR UBE2D1 CHEK2 MAPK9 MAPK14 HIPK2 RPL11 PPP2CA MDM2 HUWE1 MAPK8 YY1 TRIM28 EP300 RCHY1 BIOCARTA_SHH_PATHWAY%MSIGDB_C2%BIOCARTA_SHH_PATHWAY BIOCARTA_SHH_PATHWAY DYRK1A DYRK1B SHH SMO GLI3 PRKAR1B SUFU PTCH1 PRKAR1A GSK3B PRKACG PID_FAS_PATHWAY%MSIGDB_C2%PID_FAS_PATHWAY PID_FAS_PATHWAY PIK3R3 PIK3CD SYK PIK3R2 MAPK9 MAPK14 PIK3R1 IKBKB MAPK11 MAP3K1 BTK SRC CHUK MAPK10 SMPD1 TNFSF6 RIPK1 IKBKG MAP2K6 PIK3CA MAPK8 PDPK1 EZR CASP10 FAIM2 hCG_16983 CASP3 FADD RFC1 BIRC2 CLTC BIRC3 BIOCARTA_INSULIN_PATHWAY%MSIGDB_C2%BIOCARTA_INSULIN_PATHWAY BIOCARTA_INSULIN_PATHWAY SLC2A4 GRB2 SOS1 CSNK2A1 HRAS JUN SHC1 PIK3R1 FOS RAF1 IRS1 PTPN11 INSR MAP2K1 MAPK3 PIK3CA MAPK8 BIOCARTA_ERAD_PATHWAY%MSIGDB_C2%BIOCARTA_ERAD_PATHWAY BIOCARTA_ERAD_PATHWAY FBXO2 EDEM1 UBE2I SEC61A1 HEL-S-164nA CANX GCS1 UBA2 UGGT1 SAE1 MAN2A2 MAN1A2 SKP1 MAN1A1 MAN2C1 RBX1 BIOCARTA_EIF_PATHWAY%MSIGDB_C2%BIOCARTA_EIF_PATHWAY BIOCARTA_EIF_PATHWAY EIF4A1 EIF4G1 EIF3A EIF5 EIF6 EEF2K EIF4E EIF1AX EIF2S2 SUI1 EIF4A2 EIF2S1 EIF2S3 AAG1 PID_BCR_5PATHWAY%MSIGDB_C2%PID_BCR_5PATHWAY PID_BCR_5PATHWAY MAPK1 DAPP1 BLNK TRAF6 BTK MAP3K1 CHUK PLCG2 IKBKG POU2F2 VAV2 FLJ00120 FOS PAG1 CD19 SH3BP5 CSK CD72 IBTK CD22 NFATC1 PPP3CA PPP3CC PTPN6 CSNK2A1 SYK JUN SHC1 MAPK14 IKBKB PIK3R1 NFKBIA BCL10 RELA RAC1 MAP3K7 CD79B LYN CD79A CAMK2G MAP2K1 MAPK3 NFKB1 PIK3CA PTEN PDPK1 MAPK8 GRB2 SOS1 HRAS NFKBIB RAF1 DOK1 FCGR2B BCL2A1 MAP4K1 PTPRC PID_ER_NONGENOMIC_PATHWAY%MSIGDB_C2%PID_ER_NONGENOMIC_PATHWAY PID_ER_NONGENOMIC_PATHWAY NRAS ROCK2 GNB1 GNAL SHC1 PIK3R1 MAPK11 KRAS SRC HEL70 PELP1 HBEGF ESR2 GNAZ GNAI3 PIK3CA GNAI1 GNA14 GNA15 IGF1R GNA11 GRB2 SOS1 HRAS GNAO1 ARHA MMP2 PLCB3 GNAQ STRN PLCB1 PLCB2 GNA13 GNG2 MMP9 BIOCARTA_WNT_LRP6_PATHWAY%MSIGDB_C2%BIOCARTA_WNT_LRP6_PATHWAY BIOCARTA_WNT_LRP6_PATHWAY WNT8A WNT8B FZD1 DKK2 DKK1 PID_INTEGRIN5_PATHWAY%MSIGDB_C2%PID_INTEGRIN5_PATHWAY PID_INTEGRIN5_PATHWAY VCAM1 TGFBR1 ITGB8 ITGB7 ITGA4 ITGB6 MADCAM1 VTN EDIL3 SDC1 ITGAV ITGB5 FBN1 PLAUR BIOCARTA_INTRINSIC_PATHWAY%MSIGDB_C2%BIOCARTA_INTRINSIC_PATHWAY BIOCARTA_INTRINSIC_PATHWAY COL4A6 COL4A5 F11 F2R FGA F10 HEL-S-78p F8 PROC SERPING1 PROS1 KLKB1 KNG1 COL4A2 COL4A1 F5 COL4A4 SERPINC1 COL4A3 BIOCARTA_TID_PATHWAY%MSIGDB_C2%BIOCARTA_TID_PATHWAY BIOCARTA_TID_PATHWAY IFNGR1 IFNGR2 IFNG WT1 IKBKB NFKBIA RB1 RELA TNFRSF1B TNFRSF1A TNF-alpha USH1C LIN7A TAX1BP3 NFKB1 BIOCARTA_CELL2CELL_PATHWAY%MSIGDB_C2%BIOCARTA_CELL2CELL_PATHWAY BIOCARTA_CELL2CELL_PATHWAY CTNNA1 PECAM1 ACTN1 LRRTM2 CTNNB1 CTNNA3 CTNNA2 HEL114 CSK BIOCARTA_FBW7_PATHWAY%MSIGDB_C2%BIOCARTA_FBW7_PATHWAY BIOCARTA_FBW7_PATHWAY TFDP1 CDK2 CCNE1 RB1 CDC34 FBXW7 SKP1 BIOCARTA_FLUMAZENIL_PATHWAY%MSIGDB_C2%BIOCARTA_FLUMAZENIL_PATHWAY BIOCARTA_FLUMAZENIL_PATHWAY GABRA2 PRKCE HEL-S-44 GPX1 GABRA6 GABRA5 GABRA4 GABRA3 PID_S1P_S1P1_PATHWAY%MSIGDB_C2%PID_S1P_S1P1_PATHWAY PID_S1P_S1P1_PATHWAY VEGFA MAPK1 GNAO1 ARHA PTGS2 ITGB3 ABCC1 PLCB2 RAC1 ITGAV DKFZp434N101 SPHK1 MAPK3 GNAZ S1PR1 GNAI3 GNAI1 KDR BIOCARTA_RAN_PATHWAY%MSIGDB_C2%BIOCARTA_RAN_PATHWAY BIOCARTA_RAN_PATHWAY RAN RANBP2 RCC1 RANBP1 BIOCARTA_SKP2E2F_PATHWAY%MSIGDB_C2%BIOCARTA_SKP2E2F_PATHWAY BIOCARTA_SKP2E2F_PATHWAY TFDP1 CDK2 SKP2 CCNE1 RB1 CDC34 SKP1 BIOCARTA_BCR_PATHWAY%MSIGDB_C2%BIOCARTA_BCR_PATHWAY BIOCARTA_BCR_PATHWAY CALM2 SYK JUN SHC1 MAPK14 MAP3K1 BTK NFATC4 RAC1 CD79B LYN DKFZp434N101 CD79A MAP2K1 MAPK3 MAPK8 GRB2 SOS1 HRAS FOS NFATC3 RAF1 VAV1 HEL-S-72 PRKCB NFATC2 NFATC1 PRKCA PPP3CA PPP3CC BIOCARTA_HBX_PATHWAY%MSIGDB_C2%BIOCARTA_HBX_PATHWAY BIOCARTA_HBX_PATHWAY GRB2 SOS1 CREB1 PTK2B HRAS SHC1 LAMTOR5 PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY%MSIGDB_C2%PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY PID_P38_ALPHA_BETA_DOWNSTREAM_PATHWAY KRT19 RPS6KA5 CREB1 CSNK2A1 JUN CSNK2A2 MITF-C MAPK14 ATF1 PPARGC1A MAPK11 CSNK2B RAB5A EIF4E CEBPB PTGS2 ATF2 MKNK1 HEL-S-102 DDIT3 MAPKAPK2 MAPKAPK5 MEF2C RPS6KA4 MAPKAPK3 NOS2 GDI1 EIF4EBP1 USF1 PID_RET_PATHWAY%MSIGDB_C2%PID_RET_PATHWAY PID_RET_PATHWAY PDLIM7 DOK4 MAPK1 DOK5 CREB1 DOK6 NCK1 JUN SHC1 PIK3R1 SRC GRB10 RAP1A RAC1 PTPN11 MAPK3 PIK3CA CRK MAPK8 GRB2 SOS1 HRAS ARHA FRS2 RET DOK1 GRB7 IRS1 PXN DKFZp666O0110 PRKCA GDNF BIOCARTA_AGR_PATHWAY%MSIGDB_C2%BIOCARTA_AGR_PATHWAY BIOCARTA_AGR_PATHWAY CHRNA1 MAPK1 DAG1 DMD JUN AGRN PAK4 NRG1 NRG2 CDC42 NRG3 RAC1 MUSK ACTA1 RAPSN MAPK3 LAMA4 MAPK8 DVL1 SP1 CHRM1 ITGB1 LAMA3 GIT2 EGFR PAK1 BIOCARTA_LAIR_PATHWAY%MSIGDB_C2%BIOCARTA_LAIR_PATHWAY BIOCARTA_LAIR_PATHWAY C7 VCAM1 IL6 ITGA4 ITGB1 HEL-S-62p IL1A SELPLG IL8 TNF-alpha SELP KNG1 C6 BIOCARTA_TUBBY_PATHWAY%MSIGDB_C2%BIOCARTA_TUBBY_PATHWAY BIOCARTA_TUBBY_PATHWAY PLCB1 TUB CHRM1 GNAQ BIOCARTA_GPCR_PATHWAY%MSIGDB_C2%BIOCARTA_GPCR_PATHWAY BIOCARTA_GPCR_PATHWAY CALM2 CREB1 HRAS JUN FOS ADCY1 NFATC3 NFATC4 GNAQ RAF1 HEL-S-72 DKFZp434N101 MAP2K1 PRKCB PRKAR1B NFATC2 RPS6KA3 MAPK3 NFATC1 PRKAR1A PRKCA PRKACG PPP3CA PPP3CC PID_INTEGRIN_A4B1_PATHWAY%MSIGDB_C2%PID_INTEGRIN_A4B1_PATHWAY PID_INTEGRIN_A4B1_PATHWAY VCAM1 ITGA4 IGSF8 CD81 THBS2 ADAM28 SRC AMICA1 RAC1 ARF6 PRKAR1B PRKAR1A TLN1 JAM2 CRK MYH2 CD14 PTK2B ITGB1 opn PTPRA YWHAZ THBS1 PXN MDK DOCK1 DKFZp666O0110 BIOCARTA_CHEMICAL_PATHWAY%MSIGDB_C2%BIOCARTA_CHEMICAL_PATHWAY BIOCARTA_CHEMICAL_PATHWAY BCL2 CASP6 ATM BAD CASP9 CASP3 BAX STAT1 PARP1 PRKCB EIF2S1 APAF1 PRKCA TLN1 BIOCARTA_SPPA_PATHWAY%MSIGDB_C2%BIOCARTA_SPPA_PATHWAY BIOCARTA_SPPA_PATHWAY MAPK1 F2RL3 SYK HRAS F2R ITGB1 PTGS1 TBXAS1 RAF1 PLCB1 MAP2K1 PRKCB MAPK3 PRKCA PID_HIF2PATHWAY%MSIGDB_C2%PID_HIF2PATHWAY PID_HIF2PATHWAY VEGFA APEX1 SLC11A2 POU5F1 ADORA2A EIF3E FXN FLT1 EGLN2 CREBBP KDR TCEB1 CITED2 VHL EPO HIF1AN MMP14 SP1 HEL-S-68p ABCG2 BHLHB2 SERPINE1 TWIST1 EP300 EGLN1 EGLN3 EFNA1 SIRT1 BIOCARTA_SRCRPTP_PATHWAY%MSIGDB_C2%BIOCARTA_SRCRPTP_PATHWAY BIOCARTA_SRCRPTP_PATHWAY CDC2 GRB2 VPS16 PRKCB PTPRA PRKCA DKFZp686G14213 CSK CCNB1 PID_EPHRINB_REV_PATHWAY%MSIGDB_C2%PID_EPHRINB_REV_PATHWAY PID_EPHRINB_REV_PATHWAY BLK EPHB2 EPHB1 TIAM1 EPHB4 YES1 PIK3R1 c-fgr MAP2K4 SRC ITGB3 RAC1 MAP3K7 LYN FYN PIK3CA LCK MAPK8 PTPN13 NCK2 FGA ITGA2B CXCR4 HEL-S-78p EFNB2 EFNB1 PID_CD40_PATHWAY%MSIGDB_C2%PID_CD40_PATHWAY PID_CD40_PATHWAY IL4 JUN MAPK9 MAPK14 CD40 MAP2K4 NFKBIA MAPK11 MAP3K1 TRAF6 RELA MAPK10 CD40LG MYC TRAF2 DKFZp686J04131 C4BPA JAK3 TRAF3 FCAMR NFKB1 MAPK8 BCL2L1 TNFAIP3 TRAF1 BIRC2 BIRC3 PID_MTOR_4PATHWAY%MSIGDB_C2%PID_MTOR_4PATHWAY PID_MTOR_4PATHWAY NRAS MAPK1 CCNE1 MAPKAP1 MLST8 PML KRAS RICTOR SGK1 BRAF RB1CC1 CDK2 EEF2K TSC2 IRS1 DDIT4 BNIP3 PRKCA RPS6KA1 EIF4A1 PLD2 SFN IKBKB PPARGC1A HEL2 TSC1 RHEB RAC1 hCG_2039433 EIF4E DKFZp434G0310 RRAGA MAP2K1 RRAGB MTOR RRAGD MAPK3 ULK2 ULK1 RRN3 RPS6KB1 EIF4B PDPK1 YWHAQ HEL-S-1 MAP2K2 HRAS YWHAG ARHA YWHAZ RAF1 YY1 raptor DEPTOR PXN AKT1S1 CYCS EIF4EBP1 BIOCARTA_PPARA_PATHWAY%MSIGDB_C2%BIOCARTA_PPARA_PATHWAY BIOCARTA_PPARA_PATHWAY SRA1 NR1H3 MAPK1 NCOA1 NCOR2 MED1 RXRA LPL JUN PIK3R1 PPARGC1A NFKBIA RELA MYC ME1 NCOR1 PDGFA PRKAR1B MAPK3 CREBBP PRKAR1A PRKACG PIK3CA NR1C1 CITED2 MRPL11 DUT APOA2 FABP1 STAT5B ACOX1 EHHADH SP1 PTGS2 RB1 APOA1 TNF-alpha EP300 PRKCB NOS2 PRKCA NR0B2 BIOCARTA_ALTERNATIVE_PATHWAY%MSIGDB_C2%BIOCARTA_ALTERNATIVE_PATHWAY BIOCARTA_ALTERNATIVE_PATHWAY C7 C9 CFP CFD C8A HEL-S-62p C6 PID_P73PATHWAY%MSIGDB_C2%PID_P73PATHWAY PID_P73PATHWAY CCNA2 BAK1 GDF15 CCNE2 MAPK11 PML hCG_20684 NTRK1 BAX BCL2L11 PIN1 TP53AIP1 BRCA2 HTATIP CHEK1 FASN RAD51 CLCA2 ADA FLOT2 CDC2 AEN CDK2 TP73 TUBA1A TP63 S100A2 PLK1 CCNB1 SERPINA1 SFN PLK3 HEY2 MAPK14 FOXO3 WWOX DKFZp451O0517 RELA BIN1 MYC TP53I3 CDK6 GATA1 JAK1 MDM2 JAG2 BBC3 RNF43 SP1 UBE4B ITCH WT1 HAGH PFDN5 FBXO45 GRAMD4 RB1 HSF1 CDKN1A DEDD D4S234E DCP1B SERPINE1 PPAP2A EP300 AFP RCHY1 SIRT1 PID_WNT_CANONICAL_PATHWAY%MSIGDB_C2%PID_WNT_CANONICAL_PATHWAY PID_WNT_CANONICAL_PATHWAY AXIN1 DKFZp586M1622 DVL1 DVL2 GSK3A FZD5 WNT3A CTNNB1 GSK3B APC KLHL12 STM7 PPP2R5A NKD2 PI4K2A LRP6 CSNK1G1 PID_KIT_PATHWAY%MSIGDB_C2%PID_KIT_PATHWAY PID_KIT_PATHWAY PTPN6 SOCS1 SHC1 MITF-C PIK3R1 FOXO3 BAD STAT3 GSK3B SH2B3 GRB10 TEC Pe1Fe6 SNAI2 LYN PTPN11 MAP2K1 MAPK3 CREBBP GRAP2 CRKL PIK3CA PTEN RPS6KB1 EPO MAPK8 PDPK1 EPOR CBL BCL2 GRB2 KITLG SOS1 KIT MAP2K2 HRAS MATK SH2B2 RAF1 DOK1 STAT1 PTPRO PIK3C2B SPRED1 VAV1 BRDG1 MAP4K1 PID_ERBB1_INTERNALIZATION_PATHWAY%MSIGDB_C2%PID_ERBB1_INTERNALIZATION_PATHWAY PID_ERBB1_INTERNALIZATION_PATHWAY NRAS KIAA0142 PIK3R3 PIK3CD PIK3R2 SHC1 UBE2D3 PIK3R1 LRIG1 SYNJ1 KRAS SRC TSG101 CDC42 EPN1 RAB5A PIK3CA CBL GRB2 SOS1 HRAS EGF RAF1 UBE2D2 SPRY2 ZFYVE28 ITSN1 HGS CHMP3 UBE2D1 AMPH DKFZp666O0110 DKFZp686B23205 EGFR BIOCARTA_MSP_PATHWAY%MSIGDB_C2%BIOCARTA_MSP_PATHWAY BIOCARTA_MSP_PATHWAY IL1B TNF-alpha CCL2 CSF1 BIOCARTA_ERK5_PATHWAY%MSIGDB_C2%BIOCARTA_ERK5_PATHWAY BIOCARTA_ERK5_PATHWAY NTRK1 GRB2 MAPK1 CREB1 HRAS DKFZp434N101 SHC1 PIK3R1 MAPK3 PIK3CA MAPK7 RPS6KA1 BIOCARTA_CTBP1_PATHWAY%MSIGDB_C2%BIOCARTA_CTBP1_PATHWAY BIOCARTA_CTBP1_PATHWAY CTBP1 UBE2I SUMO1 UBA2 SAE1 PID_FGF_PATHWAY%MSIGDB_C2%PID_FGF_PATHWAY PID_FGF_PATHWAY FGF18 FGFR4 FGFR3 FGFR1 MAPK1 RUNX2 FGFR2 BGLAP JUN SHC1 PIK3R1 PAK4 NCAM1 SRC CAMK2A CDH2 PTPN11 DKFZp434N101 FGF4 MAPK3 PIK3CA PDPK1 PLAUR CBL GRB2 STAT5B SOS1 PTK2B FOS FRS2 opn SSH1 STAT1 HGF FGF2 FGF6 SPRY2 FGF8 FGF9 CTNND1 FGF23 SDC2 MMP9 FGF17 RPS6KA1 FGF19 BIOCARTA_DEATH_PATHWAY%MSIGDB_C2%BIOCARTA_DEATH_PATHWAY BIOCARTA_DEATH_PATHWAY TNFSF10 BCL2 CASP10 CASP6 TNFRSF25 hCG_16983 NFKBIA RELA CHUK CASP9 TRADD CASP3 TRAF2 FADD DKFZp686J04131 LMNA DFFB RIPK1 DFFA NFKB1 GAS2 APAF1 BIRC2 BIRC3 PID_MYC_REPRESS_PATHWAY%MSIGDB_C2%PID_MYC_REPRESS_PATHWAY PID_MYC_REPRESS_PATHWAY CREB1 RBL1 GFI1 NFYA CLU FTH1 NFYB SLC11A1 NFYC SFRP1 TMEFF2 CSDE1 TMEM126A ALDH9A1 CEBPA S100A7 NDRG2 GTF2H2 TBP SFXN3 MXD4 IRF8 PTPA CEBPD CCND1 TSC2 SPI1 DKK1 ID2 HDAC3 DNTT GADD45A FOXO3 MYC ITGA6 SMAD2 SMAD4 ITGB4 CDKN2B BCL2 ERBB2 SP1 HDAC1 MAX ITGB1 CDKN1A COL1A2 CDKN1B BRCA1 DDIT3 EP300 CCL5 BIOCARTA_CELLCYCLE_PATHWAY%MSIGDB_C2%BIOCARTA_CELLCYCLE_PATHWAY BIOCARTA_CELLCYCLE_PATHWAY CDKN2B CDC2 RBL1 TFDP1 CDK2 CDK7 CCNE1 CCNH CCND1 RB1 CDKN1A CDKN1B CCND2 CDK6 CCND3 CDKN2D CDK4 CDKN2C CDKN2A CCNB1 PID_INTEGRIN1_PATHWAY%MSIGDB_C2%PID_INTEGRIN1_PATHWAY PID_INTEGRIN1_PATHWAY COL4A6 COL4A5 NPNT NID1 ITGAV CSPG4 COL2A1 JAM2 COL6A1 PLAUR COL11A2 COL5A2 FGA HEL-S-78p TGFBI VEGFA VCAM1 HEL-S-45 ITGA4 ITGA2 ITGA1 IGSF8 CD81 THBS2 COL1A1 ITGA7 VTN ITGA6 FBN1 COL18A1 LAMA5 LAMA4 LAMC2 LAMC1 CD14 F13A1 LAMB3 LAMB2 ITGB1 opn LAMB1 COL3A1 COL1A2 LAMA1 LAMA3 TNC THBS1 MDK COL4A1 COL4A4 COL4A3 BIOCARTA_CBL_PATHWAY%MSIGDB_C2%BIOCARTA_CBL_PATHWAY BIOCARTA_CBL_PATHWAY CBL GRB2 SH3GLB1 SH3GLB2 PDGFRA PRKCB EGF PRKCA CSF1R EGFR BIOCARTA_NTHI_PATHWAY%MSIGDB_C2%BIOCARTA_NTHI_PATHWAY BIOCARTA_NTHI_PATHWAY NR3C1 TGFBR1 TGFBR2 MAP2K3 MAPK14 IKBKB NFKBIA MAPK11 RELA CHUK DKFZp686J04131 IL8 IL1B TNF-alpha MAP3K7 EP300 MYD88 MAP2K6 CREBBP SMAD4 NFKB1 BIOCARTA_GATA3_PATHWAY%MSIGDB_C2%BIOCARTA_GATA3_PATHWAY BIOCARTA_GATA3_PATHWAY IL4 GATA3 IL5 MAP2K3 MAPK14 PRKAR1B NFATC2 PRKAR1A NFATC1 PRKACG IL13 BIOCARTA_RAS_PATHWAY%MSIGDB_C2%BIOCARTA_RAS_PATHWAY BIOCARTA_RAS_PATHWAY HRAS PIK3R1 ARHA BAD RELA CHUK CASP9 RAF1 CDC42 RAC1 MAP2K1 MAPK3 RALBP1 NFKB1 RALA PIK3CA FOXO4 BIOCARTA_IGF1_PATHWAY%MSIGDB_C2%BIOCARTA_IGF1_PATHWAY BIOCARTA_IGF1_PATHWAY IGF1 IGF1R GRB2 SOS1 CSNK2A1 HRAS JUN SHC1 PIK3R1 FOS RAF1 IRS1 PTPN11 MAP2K1 MAPK3 PIK3CA MAPK8 BIOCARTA_PYK2_PATHWAY%MSIGDB_C2%BIOCARTA_PYK2_PATHWAY BIOCARTA_PYK2_PATHWAY MAPK1 CALM2 JUN SHC1 MAP2K3 MAPK14 MAP2K4 MAP3K1 RAC1 DKFZp434N101 MAP2K1 MAPK3 CRKL MAPK8 GRB2 SOS1 PTK2B MAP2K2 HRAS GNAQ RAF1 HEL-S-72 PRKCB PRKCA PAK1 PID_AR_PATHWAY%MSIGDB_C2%PID_AR_PATHWAY PID_AR_PATHWAY RANBP9 KDM1A XRCC5 MED1 NKX3-1 UBE2I CARM1 CDK6 PELP1 UBA3 TMPRSS2 KDM3A KLK3 TMF1 TGFB1I1 TGIF1 ZMIZ1 HNRPA1 APPL1 SVIL CDKN2A KDM4C NCOA6 PA2G4 FHL2 hCG_2042738 LATS2 PTK2B MAK ZNF318 CMTM2 CTDSP1 ZNF278 PIAS1 CTDSP2 hCG_16983 VAV3 CCND1 CTNNB1 TCF4 FKBP4 UBE3A BRCA1 CCND3 PRKDC RPS6KA3 PAWR BIOCARTA_AT1R_PATHWAY%MSIGDB_C2%BIOCARTA_AT1R_PATHWAY BIOCARTA_AT1R_PATHWAY GRB2 MAPK1 SOS1 CALM2 PTK2B MAP2K2 HRAS JUN SHC1 MAP2K4 ATF2 MAP3K1 GNAQ AGTR1 RAF1 RAC1 HEL-S-72 MAP2K1 PRKCB MAPK3 PRKCA EGFR PAK1 MAPK8 BIOCARTA_CCR5_PATHWAY%MSIGDB_C2%BIOCARTA_CCR5_PATHWAY BIOCARTA_CCR5_PATHWAY CCL4 CALM2 PTK2B JUN MAPK14 FOS CCR5 GNAQ CXCR4 HEL-S-72 DKFZp434N101 PRKCB CCL2 PRKCA MAPK8 CXCL12 BIOCARTA_EPONFKB_PATHWAY%MSIGDB_C2%BIOCARTA_EPONFKB_PATHWAY BIOCARTA_EPONFKB_PATHWAY DKFZp564M2422 HIF1A NFKBIA NFKB1 GRIN1 CDKN1A RELA EPO EPOR HALLMARK_PI3K_AKT_MTOR_SIGNALING%MSIGDB_C2%HALLMARK_PI3K_AKT_MTOR_SIGNALING HALLMARK_PI3K_AKT_MTOR_SIGNALING DKFZp434N101 ATF1 GSK3B HEL-S-71 ARF1 CDKN1A raptor CDKN1B CLTC UBE2D3 PTEN PRKAG1 SLA ECSIT HEL-S-125m GNGT1 RPS6KA3 FGF6 TBK1 PPP2R1B RPS6KA1 HEL-S-1 RAC1 HRAS MAP3K7 AP2M1 NCK1 MAP2K3 ACTR3 VAV3 ACTR2 PLA2G12A DUSP3 PRKCB TSC2 TRAF2 IRAK4 NGF TNFRSF1A TIAM1 LCK DDIT3 AKT1S1 CSNK2B TRIB3 PFN1 RAF1 PLCB1 SQSTM1 RALB PRKAA2 CAB39 MAPKAP1 CXCR4 PIK3R3 ITPR2 DAPP1 NOD1 HEL-S-99n IL2RG EGFR ACACA HEL-S-15 HEL-S-47e MAPK9 GNA14 MAPK8 MKNK1 ADRBK1 MAPK1 SFN RIPK1 EIF4E FGF22 MAP2K6 PAK4 SMAD2 STAT2 PTPN11 CDC2 FGF17 IL4 MAPK10 PIKFYVE RIT1 TNFSF6 ARPC3 CDK4 CAMK4 CDK2 PIN1 GRB2 MYD88 NFKBIB HALLMARK_MYOGENESIS%MSIGDB_C2%HALLMARK_MYOGENESIS HALLMARK_MYOGENESIS CTF1 CKMT2 EFS ERBB3 CHRNG DKFZp779O2152 TNNI1 TNNI2 DMD NCAM1 CACNG1 MEF2D PDLIM7 SH3BGR SPDEF SH2B1 NQO1 SVIL AGL MYBPH PDE4DIP SORBS3 COL3A1 MYO1C KLF5 PC SCD FKBP1B TCAP AGRN LPIN1 CRAT PFKM CDKN1A TSC2 RIT1 EIF4A2 RB1 APP SPARC HEL-S-273 COX6A2 FGF2 ENO3 CLU MYLK DKFZp686P11128 SLN GJA5 MYOZ1 KCNH1 EPHB3 CHRNB1 GABARAPL2 MEF2C ACSL1 FST DAPK2 IFRD1 MYL4 MYL7 ADCY9 COL4A2 PPP1R3C BIN1 MYL1 MYL2 ADAM12 MYL3 PVALB CHRNA1 CFD NOTCH1 FLII AK1 BHLHB2 PSEN2 hD53 AEBP1 FOXO4 COX7A1 CNN3 SYNGR2 STC2 LARGE BAG1 IGFBP7 MYH11 APOD WWTR1 PRNP FDPS TGFB1 GADD45B DMPK CAV3 IGF1 OCEL1 MYLPF COL1A1 GNAO1 REEP1 SLC6A8 PKIA FXYD1 HRC MYF6 SSPN PLXNB2 GLNG RYR1 ITGB1 MYOM1 ACHE ITGB5 ITGB4 SCHIP1 HSPB8 FHL1 MYL6B LDB3 PYGM MYOM2 DKFZp686M02159 HSPB2-C11orf52 CSRP3 SGCD SGCA BDKRB2 SPEG ANKRD2 CD36 SGCG HEL-S-101 MYOG TEAD4 MYBPC3 PTGIS GPX3 TNNC1 SPHK1 DENND2B GAA TNNC2 PGAM2 NAV2 HEL-S-29 SIRT2 ACTA1 MYH1 MYH2 PTP4A3 TNNT1 TNNT3 CASQ2 MYH8 ITGA7 PICK1 MYH9 MAPRE3 CASQ1 KIFC3 MYH4 tmp_locus_29 HBEGF MYH7 HDAC5 HALLMARK_PROTEIN_SECRETION%MSIGDB_C2%HALLMARK_PROTEIN_SECRETION HALLMARK_PROTEIN_SECRETION SNAP23 ICA1 ARF1 CLTA RAB22A OK/KNS-cl.3 GOLGA4 CLTC SCRN1 AP1G1 LAMP2 KIF1B AP3S1 ATP7A CTSC TPD52 RPS6KA3 DST STX7 COG2 ADAM10 OCRL AP3B1 ARFGAP3 SCAMP3 RER1 AP2M1 TMX1 ZW10 RAB2 SYBL1 ERGIC3 VAMP4 SEC22B VAMP3 ATP6V1B1 NAPA COPB2 STX12 CD63 SSPN TMED10 TSG101 SGMS1 STX16 COPB1 VPS4B GOSR2 USO1 ATP1A1 NAPG CLN5 DKFZp686B23205 LMAN1 SNX2 TSPAN8 AP2S1 YKT6 SEC31L1 ABCA1 ARFGEF1 ARFGEF2 MON2 EGFR CAV2 BNIP3 GBF1 M6PR HEL-S-44 IGF2R ARCN1 KRT18 RAB14 MAPK1 DOP1A GNAS YIPF6 ANP32E PPT1 RAB9A GLA RAB5A RNP24 COPE BET1 HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION%MSIGDB_C2%HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION PMP22 PTX3 SNTB1 CRLF1 COL3A1 DST OXTR COL16A1 SERPINE2 WIPF1 SERPINE1 COL12A1 TNC HEL113 PLOD2 PLOD1 ENO2 LOXL1 LOXL2 CTGF CDH6 COMP RGS4 SPARC CDH2 HEL-S-273 BASP1 DPYSL3 FGF2 PRSS2 POSTN IGFBP4 MYLK PLEKHC1 DKFZp686P11128 IGFBP2 APLP1 P3H1 PCOLCE HEL-S-66 DKK1 GEM SFRP4 SFRP1 LOX COL4A1 COL8A2 BPGF-1 PPIB SCG2 MXRA5 COL4A2 PFN2 FBN2 COPA NNMT SDC4 ADAM12 HTRA1 TNFRSF11B THY1 NID2 FBLN5 DKFZp686D0714 CALD1 CXNK2 JUN VCAM1 MAGEE1 CADM1 GADD45A BDNF TFPI2 FZD8 INHBA IL6 BMP1 COL1A2 CXCL12 IL8 ID2 COL5A3 COL5A2 TGFB1 CALU GADD45B SDC1 SNAI2 TGFBI FBN1 CXCL6 ECM2 COL1A1 MCM7 ITGB3 TNFAIP3 SLC6A8 CXCL1 LAMC2 LAMC1 AREG CYR61 GLIPR1 SGCB TIMP3 ITGAV ITGB1 TIMP1 HEL-S-108 EDIL3 ITGB5 COLGALT1 TNFRSF12A IL15 ITGA2 MMP2 MMP3 DKFZp564O1822 PLAUR GPX7 EMP3 opn DCN SGCD RHOB TGFBR3 GREM1 ACTA2 VCAN MMP14 SGCG CDH11 DKFZp434N181 TMEPAI GAS1 CD44 MATN3 FOXC2 PCOLCE2 LAMA1 LAMA3 THBS2 THBS1 FSTL1 PTHLH FSTL3 NT5E ABI3BP GPC1 FLNA SPOCK1 CD59 SLIT3 SLIT2 MSX1 PDLIM4 DKFZp586A1519 CTHRC1 IL32 PRRX1 VEGFC HEL-S-45 VEGFA MFAP5 FAP MGP HALLMARK_MYC_TARGETS_V1%MSIGDB_C2%HALLMARK_MYC_TARGETS_V1 HALLMARK_MYC_TARGETS_V1 EIF4A1 HEL2 HEL-S-276 RPL34 PWP1 PHB2 RPL6 UBE2L3 RRP9 EEF1B2 CDC20 FBL PSMD7 SNRPD2 TRIM28 SNRPD1 MYC RUVBL2 PSMD3 IMPDH PSMD1 HNRPD SNRPD3 TXNL4A KPNA2 RPS10 SMARCC1 STARD7 EIF1AX RPS5 RPL22 RPS6 UBE2E1 HEL-S-69 TUFM CLNS1A SNRPG VDAC3 NHP2 ERH AP3S1 SRSF7 SNRPA SET GLO1 CSTF2 NOLC1 DKFZp686P17171 PRDX3 PCBP1 DKFZp686J11229 CYC1 NOP16 ORC2L CBX3 GOT2 HEL-S-133P PA2G4 MRPL23 EIF2S2 SFRS3 EIF2S1 LSM2 SRPK1 DKFZp686A13234 AIMP2 LSM7 COPS5 EPRS1 UBA2 RNPS1 HNRNPC IARS HEL-S-97n HSP90AB1 RPLP0 HEL-S-69p YWHAQ C1QBP HNRPA3 DHX15 HNRPA1 MRPL9 TOMM70 RFC4 NCBP1 VBP1 NCBP2 PABPC4 CAD CTPS1 EIF3S1 HEL-S-68p GNL3 CCNA2 PSMA4 TFDP1 EIF3S9 PSMA2 TCP1 CANX EIF4E SNRPA1 ETF1 MCM5 PABPC1 MCM6 MCM2 HDAC2 PCNA HEL-S-91n KARS1 DDX21 U2AF1 TYMS COX5A CDK4 SRM PPM1G CDK2 HSPD1 CDC45 PSMB2 PSMB3 TRA2B POLD2 FAM120A USP1 RPS3 EIF4H RPL14 SNRPB2 RPS2 RPL18 CCT7 CCT4 NOP56 H2AZ1 RANBP1 RRM1 SF3A1 DUT SSB CNBP PTGES3 DEK HEL-S-100n IFRD1 RSL1D1 PSMC6 AAG1 XPOT PSMC4 APEX1 NDUFAB1 POLE3 PRPF31 SSBP1 TARDBP ABCE1 EIF3D RAN MAD2L1 MCM7 HALLMARK_ESTROGEN_RESPONSE_EARLY%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_EARLY HALLMARK_ESTROGEN_RESPONSE_EARLY ELOVL2 DYNLT3 ITPK1 MYOF FOS GAB2 CBFA2T3 RHOD IL17RB NCOR2 SLC7A5 MED24 ELF3 ESRP2 MPPED2 RARA TFF3 TFF1 SVIL FOXC1 CANT1 MYC SLC24A3 TMPRSS3 ATL1 SEMA3B ASB13 ADCY1 ADD3 TOB1 TMEM164 PAPSS2 SLC7A2 THSD4 MUC1 PDLIM3 OLFML3 P2RY2 LRIG1 RBBP8 SH3BP5 FAM63A HES1 FLNB DKFZp686H0575 MICB CA12 FARP1 KDM4B ZNF185 TPBG KRT13 SNX24 KLF4 hCG_1811773 DHRS2 KLK10 TTC39A DHRS3 KRT19 MLPH MYBBP1A CHPT1 RAB17 TJP3 FRK TIAM1 KRT18 SFN GLA IGFBP4 ADCY9 SCARB1 FCMR CXNK2 WWC1 BHLHB2 ABAT HR hD53 CELSR1 NADSYN1 CELSR2 AQP3 RAPGEFL1 IGF1R STC2 SOX3 DEPTOR BAG1 CCND1 RPS6KA2 CXCL12 MYB TBC1D30 CCN5 SLC39A6 SYBU MREG CISH NPY1R KAZN KCNK15 PDZK1 OVOL2 SULT2B1 OLFM1 REEP1 RAB31 SCNN1A CLDN7 HRASLS3 AREG PPIF PGR IL6ST FKBP4 SLC27A2 NBL1 PTGES FKBP5 SLC26A2 SLC22A5 HEL-S-10 ARL3 HSPB8 ABHD2 SLC1A1 RHOBTB3 ENDOD1 ISG20L2 SLC1A4 SLC9A3R1 UGCG SYNGR1 CALCR INPP5F ALDH3B1 PMAIP1 DKFZp434D2429 SLC19A2 FDFT1 XBP1 TFAP2C SLC37A1 CD44 OPN3 TIPARP WFS1 SIAH2 ABCA3 GREB1 INHBB MED13L KCNK5b NAV2 FASN BCL2 UNC119 DHCR7 RETREG1 RET LAD1 B4GALT1 CLIC3 NXT1 FHL2 PRSS23 AFF1 CALB2 CYP26B1 FAM102A ANXA9 HEL-S-45 MYBL1 MSMB TGIF2 ELOVL5 HALLMARK_CHOLESTEROL_HOMEOSTASIS%MSIGDB_C2%HALLMARK_CHOLESTEROL_HOMEOSTASIS HALLMARK_CHOLESTEROL_HOMEOSTASIS CLU SEMA3B SCD FDPS ERRFI1 GLDC TMEM97 ANTXR2 CXCL16 ACTG1 TM7SF2 FADS2 PDK3 DKFZp727E011 FBXO6 GUSB TRIB3 HEL-S-7 TNFRSF12A SC5DL HEL-S-4 STARD4 PCYT2 HMGCS1 PLAUR GPX8 AVPR1A hCG_22119 SREBF2 PLSCR1 ETHE1 DKFZp686B0215 PPARG STX5A ALDOC MVD ATF5 ATF3 FDFT1 IDI1 MVK ACSS2 LPL HMGCR ACAT2 GNAI1 ATXN2 EBP NFIL3 PMVK TP53INP1 MAL2 FASN LDLR NIBAN1 ABCA2 DHCR7 GSTM2 hCG_2024989 CHKA HEL-S-43 CYP51A1 PNRC1 FABP5 CTNNB1 CPEB2 HALLMARK_KRAS_SIGNALING_UP%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_UP HALLMARK_KRAS_SIGNALING_UP PTCD2 MAP3K1 GALNT3 TM4SF13 CCL20 H2BC3 IL10RA GABRA3 LAPTM5 NR1H4 WNT7A NAP1L2 G0S2 PSM8 DCBLD2 TMEM158 CFHR2 SPRY2 F2RL1 ADGRL4 SEMA3B KLF4 NGF CXCR4 IL2RG ERO1A SPON1 PLVAP CSF2 HCA112 F13A1 PLAT PRDM1 IKZF1 CCND2 FGF9 FBXO4 C3AR1 SOX9 EPHB2 SCN1B CMKLR1 ST6GAL1 ATG10 ANXA10 EREG CLEC4A BTC ADAM17 RBP4 PCP4 SLPI SGNE1 MALL SPARCL1 ADAM8 SCG3 TRIB1 TRIB2 ZNF277 TPH1 ABCB1 GYPC CFH LY96 KIAA0287 CSF2RA HSD11B1 PCSK1N ANKH TSPAN7 EPB41L3 PLEK2 KCNN4 TSPAN1 PRELID3B CBX8 JUP INHBA LIF IGF2 CIDEA AMMECR1 APOD PPBP GNG11 ID2 NR0B2 SNAP91 GADD45G CXCL10 YRDC BMP2 MAFB LR8 CCSER2 STRN IL7R LOH11CR2A TNFAIP3 SNAP25 PIGR NRP1 SERPINA3 MTMR10 FLT4 CROT CTSS TMEM100 AKAP12 RBM4 PRKG2 CD37 TEM5 MAP4K1 EVA1 ITGA2 CDADC1 FCER1G MMD ARG1 PLAUR EMP1 TRAF1 PDCD1LG2 opn BPGM TNFRSF1B DKFZp686G1675 DKFZp686K0257 MMP9 ETV4 ETV5 MMP10 WDR33 LAT2 MMP11 HEL-76 ZNF639 IL1B ALDH1A2 PECAM1 TLR8 IRF8 LCP1 ANGPTL4 DOCK2 BIRC3 SDCCAG8 ENG PPP1R15A SATB1 RGS16 USP12 USH1C KIAA0241 GLRX RETN PTGS2 HOXD11 CBL TFPI PRRX1 HDAC9 IL1RL2 RELN HBEGF GPNMB CBR4 IL33 HALLMARK_NOTCH_SIGNALING%MSIGDB_C2%HALLMARK_NOTCH_SIGNALING HALLMARK_NOTCH_SIGNALING SAP30 NOTCH1 RBX1 LFNG HEYL KAT2A PSEN2 ST3GAL6 SKP1 HES1 CCND1 PSENEN FZD1 NOTCH3 TCF7L2 FZD5 MAML2 FZD7 DTX1 DTX2 PRKCA DTX4 DKFZp434N181 NR1C2 HALLMARK_UV_RESPONSE_DN%MSIGDB_C2%HALLMARK_UV_RESPONSE_DN HALLMARK_UV_RESPONSE_DN PMP22 MYC COL3A1 ADD3 PRKCA ICA1 CDKN1B IRS1 PRDM2 NR3C1 PTEN ZMIZ1 AKT3 CDON hCG_2043421 IGFBP5 SFMBT1 PRKCE DKFZp451M2318 DYRK1A DKFZp686A1195 RUNX1 INPP4B SCN8A MAP1B AMPH PLPP3 MT1E PTGFR YTHDC1 INSIG1 SDC2 CACNA1A KALRN LTBP1 ATXN1 GRK5 MAP2K5 DMAC2L FZD2 NR1D2 NFKB1 ID1 CDK13 BMPR1A PHF3 CITED2 CELF2 PIK3CD PTPN21 PTPRM EDG2 VLDLR SYNE1 PIK3R3 NIPBL DBP SIPA1L1 SLC22A18 ABCC1 PPARG WDR37 ANXA2 ANXA4 F3 TGFBR2 VAV2 ARHGEF9 PLCB4 MMP16 ADORA2B KCNMA1 KIT RASA2 MGLL MRPS31 SRI ATP2C1 SLC7A1 RXRA LDLR ERBB2 SPOP HAS2 FYN APBB2 POLS SERPINE1 MGMT ATP2B4 ATP2B1 CDC42BPA MAPK14 PEX14 ACVR2A FAM179B NFIB AGGF1 FLJ20323 ADGRL2 RGS4 FBLN5 DKFZp686D0714 CXNK2 BHLHB2 BDNF IGF1R COL1A2 COL5A2 SNAI2 COL1A1 ITGB3 NRP1 LAMC1 CYR61 SCHIP1 TGFBR3 DKFZp434N181 FHL2 TFPI HALLMARK_SPERMATOGENESIS%MSIGDB_C2%HALLMARK_SPERMATOGENESIS HALLMARK_SPERMATOGENESIS LPIN1 VDAC3 RFC4 CDC2 CAMK4 HEL-S-278 CLPB CHRM4 GFI1 ACRBP CCT6B TEKT2 NEK2 PAPOLB IL13RA2 AGFG1 TLE4 PRM2 CSNK2A2 ZPBP PIAS2 ADAM2 IHPK1 ZC2HC1C THEG MTNR1A SGNE1 HOXB1 TSSK2 STAM2 SCG3 CFTR DPEP3 DDX4 HSPA4L ALOX15 ART3 OAZ3 FLJ13057 CCNB2 NPHP1 ZC3H14 RPL39L PCSK1N GSTM3 PDHA2 ODF1 BRAF HSPA2 H1-6 TUBA2 GPR182 RAD17 PSMG1 NF2 CNIH2 DKFZp686E10210 EZH2 CRISP2 SYCP1 MAST2 SNAP91 HEL-S-34 IDE COIL SHE HEL162 GRM8 GSG1 TOPBP1 NEFH HBZ PACRG NPY5R PARP2 DCC ELOVL3 SIRT1 TSN ARL4A DBF4 MEP1B DMC1 ACRV1 TTK TULP2 CST8 AKAP4 AURKA ZNRF4 PHKG2 TNNI3 JAM3 CLVS1 SLC12A2 DMRT1 GAD1 NAA11 SEPTIN4 HTR5A MTOR CHFR POMC DKFZp313B1621 TNP2 TNP1 CDKN3 HALLMARK_UV_RESPONSE_UP%MSIGDB_C2%HALLMARK_UV_RESPONSE_UP HALLMARK_UV_RESPONSE_UP BCL2L11 GRPEL1 HMOX1 NKX2-5 NPTX2 FOS ATP6V1C1 ATP6V1F LYN HEL-S-94n KLHDC3 EPHX1 ASNS RAB27A GGH NFKBIA EIF2S3 EIF5 NAT1 DLG4 AGO2 FGF18 CYP1A1 CDKN1C H2AX BTG3 BTG2 FEN1 BTG1 ALAS1 ONECUT1 TCHH CLTB ARRB2 CXCL2 PDLIM3 SPR CASP3 HYAL2 DKFZp686G18136 TACR3 GAL COL2A1 IRF1 SLC25A4 NUP58 HEL-S-87p CEBPG TGFBRAP1 WIZ FURIN CLCN2 RXRB PPP1R2 DNAJB1 EPCAM CREG1 MGAT1 POLR2H BAK1 E2F5 CYB5B CDKN2B MRPL23 DKFZp686O15119 DKFZp686O0451 PLCL1 NTRK3 CDC5L PDAP1 CCK FOSB CDO1 GRINA SQSTM1 AP2S1 YKT6 RFC4 ATF3 PPT1 CHKA DDX21 CDK2 ENO2 IGFBP2 POLE3 ABCB1 HSPA2 AQP3 IL6 BMP2 OLFM1 SLC6A8 PARP2 PPIF IL6ST FKBP4 RHOB MMP14 C4BPB HEL-76 CCND3 HTR7 GPX3 UROD JUNB STARD3 DGAT1 TAP1 SLC6A12 HLA-F MAPK8IP2 TUBA4A CDC34 hEMMPRIN POLG2 CCNE1 RET PRPF3 SELENOW TYRO3 TEGT MSX1 NPTXR TARS1 CNP CHRNA5 RRAD MAOA SHOX2 RPN1 SULT1A1 CYB5R1 DKFZp564M2422 HALLMARK_MYC_TARGETS_V2%MSIGDB_C2%HALLMARK_MYC_TARGETS_V2 HALLMARK_MYC_TARGETS_V2 TMEM97 AIMP2 C1orf33 NIP7 NOP56 NOP2 PPAN NOC4L RABEPK RRP9 HK2 WDR43 UNG EXOSC5 TCOF1 PES1 UTP20 MYC FARSLA MAP3K6 PLK4 DUSP2 PLK1 PRMT3 SORD WDR74 IMP4 TFB2M PPRC1 BYSL GNL3 RCL1 LAS1L NDUFAF4 GRWD1 MPHOSPH10 DCTPP1 MCM5 NOLC1 SRM CDK4 NOP16 HSPD1 CBX3 MYBBP1A PA2G4 HALLMARK_INFLAMMATORY_RESPONSE%MSIGDB_C2%HALLMARK_INFLAMMATORY_RESPONSE HALLMARK_INFLAMMATORY_RESPONSE CCL20 IL10RA LYN NFKBIA DCBLD2 MYC FZD5 BTG2 SLC7A2 P2RY2 CDKN1A TACR3 IRF1 KIF1B TPBG LCK NFKB1 RAF1 EDG2 ABCA1 F3 ADORA2B NPFFR2 IFITM1 CSF3 CSF1 SRI CD82 ATP2C1 HEL-S-75 SLC7A1 AQP9 LDLR ICAM4 AHR SLC4A4 HAS2 IL18RAP RGS1 LAMP3 SERPINE1 CCRL2 CLEC5A TNFSF10 ATP2B1 IL12B PROK2 ROS1 IL15RA ACVR2A TNLG5A IL1R1 SLC11A2 CYBB IFNAR1 LY6E CALCRL EBI2 EBI3 C5AR1 C3AR1 SLC1A2 FPR1 PSEN1 SCN1B MEFV CMKLR1 HIF1A PIK3R5 HRH1 IRAK2 EREG NLRP3 CD14 NDP SLAMF1 MSR1 TNFRSF9 EIF2AK2 MGC26963 NMI SELE BST2 PTPRE MARCO CXCL11 SELL NMUR1 MXD1 SELS RTP4 CXCL9 CD40 TNFAIP6 ATP2A2 ADM CX3CL1 GPR132 STAB1 PDE4B OLR1 ITGB8 BDKRB1 CCR7 INHBA FFAR2 LIF IL6 IL10 EDN1 PTGIR TNLG1B IL8 RIPK2 IFNGR2 IL18 GP1BA TACR1 CXCL10 OSMR TAPBP TLR1 IL1A CXCL6 RNF144B MEP1A IRF7 IL7R ITGB3 LTA CD48 LCP2 TLR3 PTGER4 PTGER2 GNAI3 KCNA3 CXCR6 NOD2 ACVR1B TIMP1 RELA GNA15 CCL7 CCL5 PDPN IL15 GPC3 CCL17 CD55 KCNJ2 CCL24 PLAUR GABBR1 CCL22 EMP3 SEMA4D SLC31A2 SLC31A1 TNFRSF1B PCDH7 ADRM1 OSM OPRK1 ARHG MMP14 P2RX7 KLF6 P2RX4 AXL IL2RB PBEF1 CD69 IL1B TNLG8A VIP SPHK1 IL18R1 RGS16 HBEGF HALLMARK_ADIPOGENESIS%MSIGDB_C2%HALLMARK_ADIPOGENESIS HALLMARK_ADIPOGENESIS CD151 RETSAT GRPEL1 MTARC2 MGST3 AK2 BAZ2A ABCB8 MRPL15 ADIPOR2 COX8 DHRS7B UBC G3BP2 APOE RREB1 DECR1 ESRRA FZD4 HEL107 IDH1 EPHX2 CHCHD10 DNAJC15 COQ5 CS COQ3 UCK1 BCL6 TOB1 REEP5 UQCRQ NMT1 PEMT CRAT NABP1 hCG_2025883 ACO2 REEP6 FAM82C SLC25A1 ORM1 RNF11 COX7B SOWAHC ETFB GPHN CPT2 HEL-S-87p ACADL ALDH2 AIFM1 NKIRAS1 DBT ME1 PRDX3 ACADM DLAT ACADS CYC1 YWHAG ADIG JAGN1 CHUK GPX4 IFNGR1 ELMOD3 ELOVL6 MRAP DKFZp686B20267 PPM1B ACOX1 NDUFS3 SLC25A10 CD302 DLD ECHS1 NDUFB7 SLC66A3 LAMA4 PTGER3 UQCR11 UQCR10 LTC4S TANK AGPAT3 ADCY6 SAMM50 DDT GPAT4 UCP2 UBQLN1 STOM ABCA1 SNCG DNAJB9 PPARG PTCD3 CDKN2C NDUFA5 CAVIN1 ANGPT1 CAVIN2 RIOK3 HEL-S-44 MDH2 HEL-S-62p LPL VEGFB CYP4B1 IMMT PFKL DHRS7 MGLL FABP4 GPAM LEP CCNG2 LPCAT3 FAM62A ATP5PO PEX14 MYLK COL4A1 SPARCL1 NDUFAB1 SCARB1 GADD45A CIDEA SSPN ARL4A HSPB8 CD36 GPX3 SLC27A1 ARAF DGAT1 GHITM COX6A1 ANGPTL4 ENPP2 PIM3 DKFZp451F173 PHYH hCG_2001986 DHCR7 OMD ATP1B3 SDHC CMBL SDHB SLC5A6 ACLY ITGA7 RETN POR ADFP TMEM77 GPD2 RAB34 CMPK1 UQCRC1 SUCLG1 SULT1A1 PREB RTN3 HALLMARK_ANDROGEN_RESPONSE%MSIGDB_C2%HALLMARK_ANDROGEN_RESPONSE HALLMARK_ANDROGEN_RESPONSE SELENOP PPAP2A SMS SGK1 HPGD STK39 TMPRSS2 KLK3 MYL12A CAMKK2 UBE2J1 PTK2B RAB4A UBE2I SPDEF HOMER2 XRCC5 DHCR24 MERTK H1-0 SPCS3 CDK6 APPBP2 VAPA CENPN GPD1L SCD ANKH ZMIZ1 TPD52 RPS6KA3 CCND1 INPP4B KRT19 PA2G4 INSIG1 GNAI3 ITGAV AKAP12 FKBP5 SLC26A2 ABHD2 PTPN21 HMGCS1 LMAN1 DKFZp686G1675 DNAJB9 ADRM1 SORD TMEPAI IDI1 CCND3 HMGCR SRP19 STEAP4 NGLY1 DBI B4GALT1 CDC14B PGM3 B2M SMP1 FADS1 NKX3-1 DKFZp779C185 ACTN1 ARID5B ACSL3 PIAS1 HEL-75 MAF ELOVL5 MAK HALLMARK_COAGULATION%MSIGDB_C2%HALLMARK_COAGULATION HALLMARK_COAGULATION LAMP2 FURIN RAC1 F3 HEL-S-62p FYN SERPINE1 PLAT COMP SPARC CLU GDA PROS1 NR2A1 CAPN5 HTRA1 DKFZp686N0152 S100A1 CFH ADAM9 SERPING1 CFD MASP2 ISCU CPB2 PEF1 CFI PROZ KLK8 C2 OLR1 DPP4 C9 TFPI2 S100A13 RAA1 A2M ADIC BMP1 GNG12 GP9 TF PROC GNB2 MAFF GP1BA F13B HRG ARF4 PGCP FBN1 SERPINA1 PLEK C8A MEP1A DUSP14 ITGB3 CASP9 THBD CTSO C8G CTSK CTSH MBL2 FGA SERPINB2 TIMP3 ANXA1 MMP7 TIMP1 VWF APOA1 F2 F8 F9 DCT ITGA2 ACOX2 MMP2 MMP15 MMP3 C1S SERPINC1 TMPRSS6 C1R USP11 HEL-S-52 PLG CRIP2 CPN1 P2RY1 MMP9 LEFTY2 SH2B2 MMP14 F10 MMP10 HEL-S-41 F11 APOC3 MMP11 KLF7 APOC2 APOC1 MSRB2 KLKB1 PECAM1 F2RL2 PF4 THBS1 SIRT2 PRSS23 HALLMARK_APOPTOSIS%MSIGDB_C2%HALLMARK_APOPTOSIS HALLMARK_APOPTOSIS BCL2L11 CYLD RETSAT DAP HMOX1 BCL2L2 BCL2L1 ERBB3 TOP2A HMGB2 BRCA1 CASP6 DKFZp686G14213 CASP4 PBR HEL-S-102 DFFA GPX1 PPP2R5B DNAJC3 RARA DPYD PLCB2 RNASEL GUCY2D ROCK1 SLC20A1 PLPPR4 NEDD9 BTG3 ADD1 BTG2 PAK1 LMNA BCAP31 BIK IFNB1 DKFZp666O0110 CD2 WEE1 CTH BAX CASP3 CDKN1A CDKN1B IRF1 GPX4 IFNGR1 DDIT3 SC5DL SQSTM1 AVPR1A hCG_22119 ATF3 HEL-S-44 IGF2R KRT18 EBP PPT1 ETF1 ERBB2 MGMT TNFSF6 TNFSF10 CTNNB1 CDK2 ENO2 HEL-75 PLAT APP CCND2 CLU PSEN1 EREG CD14 H1-0 ANKH JUN PSEN2 GADD45A IL6 CCND1 IL18 GADD45B BMP2 IL1A NEFH CASP9 TIMP3 ANXA1 TIMP1 RELA GNA15 F2 TNFRSF12A MMP2 EMP1 DCN RHOB TGFBR3 PMAIP1 CD44 CD69 GPX3 IL1B IFITM3 hCG_16983 TAP1 TNF-alpha PRF1 hCG_20684 BIRC3 DKFZp586H0919 FDXR BNIP3L HGF SATB1 F2R FEZ1 MADD TXNIP DAP3 DIABLO BCL10 PPP3R1 BCL2L10 RHOT2 BMF IGFBP6 MCL1 CREBBP GSTM1 DKFZp564M2422 ISG20 HALLMARK_APICAL_SURFACE%MSIGDB_C2%HALLMARK_APICAL_SURFACE HALLMARK_APICAL_SURFACE BRCA1 LYN ADIPOR2 HEL-S-102 DCBLD2 PLAUR IL2RG THY1 IL2RB GAS1 SRPX GSTM3 PCSK9 CX3CL1 AKAP7 LYPD3 SLC2A4 GATA3 EFNA5 PKHD1 SCUBE1 FLOT2 ATP6V0A4 EPHB4 TMEM8B SLC34A3 NTNG1 B4GALT1 ATP8B1 ADAM10 NCOA6 CD160 DKFZp781J074 SULF2 RTN4RL1 CROCC MAL GHRL RHCG MDGA1 APP HALLMARK_COMPLEMENT%MSIGDB_C2%HALLMARK_COMPLEMENT HALLMARK_COMPLEMENT LYN CASP4 CASP3 PCSK9 GATA3 LAMP2 IRF1 CTSC ME1 FCN1 HEL-S-72 DGKG CDA GMFB HEL-S-130P HEL110 LIPA HEL-S-89n DOCK10 PIM1 LCK HPCAL4 FDX1 LAP3 S100A9 PFN1 PLA2G7 HEL-S-7 RAF1 VCPIP1 PPP4C S100A12 RCE1 STX4A ADIB APOBEC3F hCG_22119 APOBEC3G BRPF3 MT3 PLSCR1 CP EHD1 GNB4 CPM DOCK4 ITGAM DYRK2 F3 DOCK9 AKAP10 PCLO GNGT2 HEL-S-62p CASP5 CTSL CASP10 KYNU KLNA1 DUSP5 CR2 CR1 SIRT6 APOA4 ADRA2B F5 MMP12 F7 PIK3CA FYN IRF2 CD46 SERPINE1 L3MBTL4 USP14 CEBPB USP15 USP16 SRC WAS GRB2 RNF4 PPM2C GNG2 SPOCK2 PLAT SH2B3 GCA KCNIP3 GZMA ATOX1 GZMK CD40LG CLU XPNPEP1 PSEN1 CDK5R1 MSRB1 PIK3R5 COL4A2 SCG3 NR2A1 DKFZp686N0152 CFH ADAM9 SERPING1 C2 OLR1 DPP4 C9 TFPI2 S100A13 RAA1 IL6 ADIC GP9 GNB2 MAFF GP1BA PGCP SERPINA1 PLEK IRF7 CASP9 TNFAIP3 CXCL1 CTSO LCP2 CTSH GNAI3 SERPINB2 CTSS TIMP1 F2 F8 CCL5 MMP15 CD55 FCER1G C1S SERPINC1 PLAUR TMPRSS6 C1R PLG ARHG CD36 MMP14 F10 C4BPB HEL-76 APOC1 KLKB1 CD59 GPD2 HALLMARK_DNA_REPAIR%MSIGDB_C2%HALLMARK_DNA_REPAIR HALLMARK_DNA_REPAIR CANT1 IMPDH FEN1 BCAP31 RBX1 POLR2H GPX4 CDA TSG101 ADCY6 RFC4 NCBP2 RNP24 PCNA TYMS MPG GTF2B hCG_40733 CLP1 HEL74 LIG1 DUT DKFZp761J032 GTF2F1 BCAM CMPK2 GC20 SRSF6 VPS28 CCNO POM121 CSTF3 NPR2 COX17 SUPT4H1 BRP44 AK3 XPC AAAS BOLA2B SDCBP ZNF707 HEL-S-156an AK1 SAC3D1 SURF1 POLR3GL UPF3B DKFZp566H033 PDE4B SUPT5H ZWINT POLA1 POLA2 AGO4 STX3A ADA ELL hCG_1994130 CETN2 SNAPC5 SEC61A1 ZNRD1 MRPL40 GUK1 SNAPC4 DKFZp781O1323 ELOA DGCR8 NELFB NELFCD RFC3 RFC2 VPS37D NME3 NME4 EDF1 VPS37B DDB2 APRT DDB1 RRM2B NFX1 POLR1C POLR1D HCLS1 UMPS RALA GTF3C5 PRIM1 GMPR2 TAF9 NT5C3 POLD3 USP11 POLD4 POLR2A POLR2C POLR2D POLR2F ADRM1 POLR2G POLR2I POLR2J RAE1 POLR2K BRF2 TAF12 TAF13 PDE6G TAF10 SSRP1 GTF2H3 TARBP2 GTF2H5 POLE4 RAD52 NUDT21 RAD51 ERCC3 POLR3C ERCC1 RPA3 ERCC2 ERCC5 TAF6 DFNA5 HALLMARK_TGF_BETA_SIGNALING%MSIGDB_C2%HALLMARK_TGF_BETA_SIGNALING HALLMARK_TGF_BETA_SIGNALING SMAD6 TGFBR1 HIPK2 SKI FKBP1A CDK9 ARHA APC ID3 NCOR2 ID1 BMPR1A SLC20A1 CDKN1C LEFTY2 TMEPAI JUNB UBE2D3 THBS1 ENG PPP1R15A FURIN WWTR1 IFNGR2 ID2 BMPR2 SERPINE1 DKFZp686A1195 HDAC1 ARID4B TGFB1 LTBP2 CTNNB1 FNTA MAP3K7 SKIL BMP2 SPTBN1 TGIF1 ACVR1 SMAD1 SMURF2 SMURF1 NOG RAB31 HALLMARK_ANGIOGENESIS%MSIGDB_C2%HALLMARK_ANGIOGENESIS HALLMARK_ANGIOGENESIS NRP1 CCND2 POSTN ITGAV TIMP1 LRPAP1 PDGFA STC1 VTN APOH PGLYRP1 JAG2 KCNJ8 PRG2 SLCO2A1 S100A4 TNFRSF21 opn FGFR1 COL3A1 VCAN DKFZp666O0110 VAV2 LPL PF4 OLR1 FSTL1 MSX1 COL5A2 CXCL6 VEGFA THBD APP HALLMARK_PEROXISOME%MSIGDB_C2%HALLMARK_PEROXISOME HALLMARK_PEROXISOME RETSAT TOP2A PBR CNBP ACSL1 DHCR24 DLG4 IDH1 EPHX2 SLC35B2 SLC23A2 ABCD2 ABCD3 ECI2 DKFZp667O1614 LOC51064 ABCB1 HEL111 STS SMARCC1 HEL-S-53e CRAT NUDT19 LONP2 MLYCD ABCD1 ACOT8 ABCC8 ABCC5 DIO1 CADM1 FACL4 ACSL5 UGT2B17 SLC25A4 PEX2 CEL GNPAT SLC25A17 MSH2 PEX6 EHHADH PEX5 ALDH9A1 CRABP2 FDPS IDE SEMA3C HRAS CTBP1 ABCB4 MVP DHRS3 PEX11B CRABP1 CACNA1B ABCB9 SULT2B1 HSD17B11 CLN8 CLN6 HMGCL ACOX1 HSD11B2 PRDX5 ATXN1 RDH11 ISOC1 HAO2 RXRG SLC27A2 HSD3B7 FIS1 NR1i2 VPS4B SIAH1 PEX13 ESR2 CDK7 FABP6 ALB SCGB1A1 CTPS1 IDI1 HEL-S-44 PABPC1 ERCC3 ERCC1 FADS1 BCL10 PEX14 ELOVL5 DKFZp564M2422 HALLMARK_ESTROGEN_RESPONSE_LATE%MSIGDB_C2%HALLMARK_ESTROGEN_RESPONSE_LATE HALLMARK_ESTROGEN_RESPONSE_LATE DYNLT3 ITPK1 MYOF TM4SF13 TOP2A FOS IL17RB NCOR2 SLC7A5 CDC20 TFF3 TFF1 FOXC1 SLC24A3 TMPRSS3 SEMA3B BTG3 ADD3 TOB1 PAPSS2 PDLIM3 RBBP8 GAL FLNB ETFB MICB CA12 FARP1 TPBG KRT13 KLF4 hCG_1811773 DHRS2 KLK10 KRT19 CHPT1 TJP3 FRK HEL110 TIAM1 PTGER3 S100A9 NAB2 CXCL14 ZFP36 TRIM29 UNC13B METTL3 PLK4 CACNA2D2 DUSP2 PRLR ALDH3A2 KIF20A SORD PKP3 LLGL2 RNASEH2A IGSF1 PLAC1 MST160 ASS ST14 STIL XRCC3 SFN CDC6 CYP4F11 TH DLG5 NMU GPER GLA PLXNB1 FGFR3 MOCS2 ST6GALNAC2 SNX10 SLC2A8 MDK IMPA2 TPSAB1 JAK1 ATP2B4 CHST8 FABP5 DCXR LSR UGDH DNAJC1 JDP1 SLC29A1 ASCL1 PERP AGR2 GINS2 COX6C BATF MAPK13 SGK1 CXNC KLNG IGFBP4 PTPN6 HOMER2 PCP4 HSPA4L SCARB1 HR hD53 CELSR2 TFPI2 RAPGEFL1 SOX3 LARGE BAG1 CCND1 RPS6KA2 CXCL12 MYB ID2 CCN5 CISH NPY1R SERPINA1 PDZK1 OVOL2 SULT2B1 OLFM1 RAB31 SCNN1A LAMC2 HRASLS3 SERPINA3 AREG PPIF PGR IL6ST FKBP4 SLC27A2 NBL1 PTGES FKBP5 SLC26A2 SLC22A5 HEL-S-10 ARL3 HSPB8 ACOX2 ABHD2 SLC1A4 SLC9A3R1 CALCR ALDH3B1 FDFT1 XBP1 TFAP2C HEL-76 CD44 OPN3 WFS1 TNNC1 SIAH2 ABCA3 KCNK5b HEL-S-29 BCL2 DHCR7 RET CLIC3 NXT1 PRSS23 AFF1 CYP26B1 FAM102A ANXA9 ISG20 ELOVL5 HALLMARK_HEME_METABOLISM%MSIGDB_C2%HALLMARK_HEME_METABOLISM HALLMARK_HEME_METABOLISM CTNS PDZK1IP1 KLF3 MGST3 FP15737 EPOR KLF1 XK HEL-S-2a RHAG YPEL5 LPIN2 ASNS TNRC6B PPP2R5B ADD1 BTG2 PC NR3C1 LAMP2 MAP2K3 DKFZp686O0451 UCP2 RIOK3 RCL1 HEL-S-62p ICAM4 USP15 DKFZp779C185 SLC11A2 ISCA1 NARF CPOX SLC4A1 BACH1 NUDT4 CCDC28A PSMD9 tal-1 RNF19A CDC27 BCAM CIR1 FBXO7 H1-0 FBXO9 TNS1 MYL4 CAST HEL-S-304 LMO2 SLC30A1 GAPVD1 RNF123 MINPP1 KEL DKFZp686N0152 DAAM1 GYPC HMBS GLND1 RHCE SDCBP OPTN OSBP2 SIDT2 ABCG2 SLC22A4 EPB42 IGSF3 ABCB6 GYPB AQP3 GYPE DKFZp686N0561 DCUN1D1 HTRA2 FLJ00380 HEL-S-11 SLC30A10 ADIPOR1 FOXO3 GATA1 RAP1GAP SPTA1 TSPAN5 CDR2 FN3K NFE2 EIF2AK1 UROS SLC10A3 DKFZp781N011 HBZ MARCH8 FBXO34 SLC6A8 TYR DKFZp686P18130 MFHAS1 ALDH6A1 GCLC SLC6A9 SYNJ1 ARL2BP P4HA2 MKRN1 RANBP10 TMCC2 DKFZp686C06176 HEL-S-10 HIST1H4J LRP10 GCLM TMEM9B EZH1 ENDOD1 PICALM ALAS2 MIR16 HEL-S-134P HBB BPGM HBD SLC7A11 FTCD HEBP1 NNT ACP5 CLIC2 ERMAP RBM5 HTATIP2 ARHGEF12 HEL-76 CCND3 VEZF1 SPTB UROD TENT5C KAT2B ERAF TFDP2 BMP2K TRIM58 HAGH KDM7A MARCHF2 SLC66A2 BNIP3L hEMMPRIN FLJ20551 MOSPD1 PPOX RHD TRAK2 ADD2 AGPAT4 FY MXI1 E2F2 DCAF10 SNCA RBM38 DMTN SMOX MOCOS FOXJ2 XPO7 HALLMARK_GLYCOLYSIS%MSIGDB_C2%HALLMARK_GLYCOLYSIS HALLMARK_GLYCOLYSIS CASP6 STC1 MED24 CHPF ELF3 ZNF292 XYLT2 HS6ST2 DPYSL4 TFF3 NDST3 SLC16A3 AGL IL13RA1 IDH1 RARS1 GLCE ALG1 MIF PHKA2 TPST1 PC CLDN3 CLDN9 DDIT4 BIK RRAGD AGRN PKP2 KDELR3 SAP30 RBCK1 ALDH7A1 CTH DSC2 GNE PFKFB1 PAXIP1 GPR87 SDC3 TGFA AK4 TXN HMMR ARPP19 HEL-S-87p HEL-S-17 FUT8 CHST12 NDUFV3 TPBG COG2 ANKZF1 LHPP ME1 HOMER1 ALDH9A1 HEL-S-165mP GFPT1 ECD SRD5A3 B3GALT6 EXT1 GOT2 EXT2 HEL-S-133P EFNA3 P4HA1 NASP SDC2 ARTN HEL20 CLN6 LHX9 GALK2 COPB2 B4GALT2 PYGB SLC25A10 HEL-S-32 HEL-S-89n HEL-S-30 DLD PYGL HS2ST1 PDK3 GMPPB GYS2 GYS1 NANP GUSB GMPPA CITED2 HK2 PGM2 ME2 HEL-S-69p MIOX CHST6 CHPF2 PGAM1 VLDLR HAX1 HEL-S-19 CXCR4 DEPDC1 B3GNT3 CHST1 ALDOB LCT KIF20A CHST4 FBP2 EGFR SLC25A13 IDUA RPE HEL-S-68p NOL3 HEL-S-44 CENPA MDH2 GPC4 EGLN3 ADORA2B SLC35A3 B3GAT3 B3GAT1 SPAG4 HEL-S-49 GNPDA1 POLR3K PFKP HEL-S-75 CDC2 PLOD2 ERO1A PLOD1 ENO2 HEL-S-278 SOX9 MERTK BPGF-1 HEL-S-304 PSMC4 CAPN5 AK3 ABCB6 STC2 RAA1 SDC1 TGFBI GCLC FKBP4 P4HA2 GPC3 AURKA DCN VCAN CD44 PGAM2 ANGPTL4 NT5E GPC1 SDHC B4GALT1 GLRX MXI1 VEGFA ISG20 HALLMARK_FATTY_ACID_METABOLISM%MSIGDB_C2%HALLMARK_FATTY_ACID_METABOLISM HALLMARK_FATTY_ACID_METABOLISM RETSAT ADIPOR2 EPHX1 G0S2 DECR1 IDH1 CYP1A1 MIF ECI2 HEL-S-53e CRAT MLYCD ACO2 REEP6 ACOT8 FACL4 ACSL5 CEL CPT2 HEL-S-87p ACADL EHHADH ME1 ACADM ALDH9A1 ACADS HEL-S-133P HSD17B11 HMGCL ACOX1 RDH11 HEL-S-32 HAO2 DLD ECHS1 LTC4S HMGCS1 ALDH3A2 IDI1 MDH2 ACAT2 MGLL ACSM3 AQP7 UBE2L6 IL4I1 TDO2 NBN hCG_2024989 PIG59 MIX23 CPT1A GABARAPL1 SDHD SDHA ALDH3A1 GPD1 UGDH ENO2 ACOT2 SUCLG2 GCDH CD1D ADH7 NTHL1 HEL-S-278 S100A10 PDHA1 NCAPH2 SMS HEL-S-128m VNN1 ENO3 OSTC HPGD SERINC1 ACADVL SETD8 CPOX CYP4A22 NR1C1 H2AZ1 HCCS PTPRG MCEE CA4 IDH3B HEL-S-107 ACSL1 DHCR24 DKFZp564P2062 HSDL2 ADSL CYP4A11 HEL-S-25 INMT HADHB FH ADH1C APEX1 HSD17B10 BPHL PTS CRYZ TP53INP2 PCBD1 D2HGDH ACSS1 AADAT GAD2 GSTZ1 FABP1 FABP2 METAP1 CIDEA UROS SLC22A5 CD36 HEL-76 UROD FASN SDHC GPD2 MAOA SUCLG1 ELOVL5 HALLMARK_PANCREAS_BETA_CELLS%MSIGDB_C2%HALLMARK_PANCREAS_BETA_CELLS HALLMARK_PANCREAS_BETA_CELLS SST DCX SRPRB IAPP INSM1 FOXA2 NEUROG3 LMO2 ABCC8 PCSK2 PCSK1 STXBP1 DPP4 SLC2A2 SRP14 AKT3 FOXO1 INS NEUROD1 SCGN NKX6-1 SEC11A NKX2-2 PKLR NR1i1 PDX1 PAX6 GCG HNF1A SYT13 MAFB ELP4 ISL1 SRP9 GCK G6PC2 SPCS1 HALLMARK_HEDGEHOG_SIGNALING%MSIGDB_C2%HALLMARK_HEDGEHOG_SIGNALING HALLMARK_HEDGEHOG_SIGNALING NRP1 CDK5R1 CNTFR LDB1 CRMP1 ACHE ETS2 AMOT SHH OPHN1 HEY1 HEY2 SLIT1 NRCAM TLE3 VLDLR PTCH1 L1CAM CDK6 PML SCG2 PLG NF1 DKFZp686J1169 THY1 CELSR1 NKX6-1 MYH9 VEGFA HALLMARK_IL2_STAT5_SIGNALING%MSIGDB_C2%HALLMARK_IL2_STAT5_SIGNALING HALLMARK_IL2_STAT5_SIGNALING DRC1 CDC42SE2 PHTF2 HIPK2 BCL2L1 CTSZ SLC2A3 ITGAE PTH1R IL10RA ZNFN1A2 GLIPR2 NFKBIZ CTLA4 SH3BGRL2 SIAT4C CCR4 BATF3 HEL-S-21 TNFRSF18 IL13 CKAP4 SERPINB6 MYC CDCP1 TNFRSF21 IRF4 CDKN1C PTRH2 IL3RA MYO1C COL6A1 TLR7 ITGA6 LTB IRF6 RRAGD SMPDL3A PLEC AHCY AHNAK MUC1 FGL2 CST7 CASP3 COCH IL1RL1 LRIG1 PLAGL1 LRRC8C DCPS GBP4 PRAF2 SPRY4 HUWE1 TTC39B ARHH MYO1E SYT11 FURIN IL2RA SNX14 ETFBKMT EEF1AKMT1 DHRS3 GPX4 IFNGR1 P4HA1 TIAM1 PIM1 NOP2 HK2 PLSCR1 ANXA4 IGF2R CDC6 NFIL3 CSF1 AHR GABARAPL1 TNFSF10 CSF2 CCND2 PPAP2A BATF ENO3 APLP1 HEL-S-66 TNFRSF9 SELL ABCB1 MXD1 S100A1 HEL-S-156an BHLHB2 SYNGR2 IGF1R LIF IL10 GATA1 PRNP MAFF GADD45B CXCL10 CISH SHE BMP2 CD48 NRP1 PTGER2 ARL4A ITGAV UMPS SERPINC1 PTCH1 EMP1 TRAF1 opn TNFRSF1B RHOB CYFIP1 CD83 GUCY1B1 CD81 ETV4 GPR65 RORA KLF6 IKZF4 P2RX4 PDCD2L XBP1 SCN9A IL2RB CAPN3 HEL-76 CD44 CCND3 TNFSF11 ENPP1 TNFRSF8 MAP3K8 F2RL2 IL18R1 DENND5A IFITM3 SLC39A8 IRF8 PHLDA1 TNFRSF4 WLS PRKCH IL1R2 BCL2 NT5E SWAP70 FLT3LG ADAM19 TWSG1 CCNE1 RGS16 MAPKAPK2 GPR83 SOCS2 BMPR2 CD79B SOCS1 PENK ADFP FREQ MAP6 SNX9 ICOS POU2F1 HEL-S-45 HOPX SELP UCK2 AMACR HALLMARK_WNT_BETA_CATENIN_SIGNALING%MSIGDB_C2%HALLMARK_WNT_BETA_CATENIN_SIGNALING HALLMARK_WNT_BETA_CATENIN_SIGNALING DKK4 CCND2 NUMB NCOR2 DKK1 HEY1 HEY2 JAG2 ADAM17 PTCH1 MYC FZD1 NR1C2 NOTCH1 KAT2A PSEN2 GNAI1 FZD8 DKFZp586H0919 HDAC2 MAML1 HDAC11 RBPJ CTNNB1 NKD1 FRAT1 DVL2 WNT1 SKP2 WNT5B AXIN1 CSNK1E HDAC5 AXIN2 HALLMARK_OXIDATIVE_PHOSPHORYLATION%MSIGDB_C2%HALLMARK_OXIDATIVE_PHOSPHORYLATION HALLMARK_OXIDATIVE_PHOSPHORYLATION RETSAT GRPEL1 MGST3 ATP6V1C1 ATP6V1F MRPL15 PHB2 COX8 DECR1 IDH1 CS ALAS1 UQCRQ ACO2 BAX COX7B VDAC3 ETFB SLC25A4 AIFM1 PRDX3 ACADM DLAT DKFZp686J11229 CYC1 GOT2 GPX4 HEL-S-133P hCG_39985 NDUFS3 MTRR HEL-S-271 HEL-S-32 MTRF1 DLD MPC1 ECHS1 PDK4 NDUFB7 PMPCA ATP6V1E1 FDX1 PDHX ATP6V1G1 UQCR11 ATP6V0E1 UQCR10 ATP1B1 COX6B1 OXA1L COX7A2L UQCRC2 UQCRB ABCB7 ATP5MC2 ATP5MC3 ATP5J TOMM70 COX7A2 ATP5H UQCRH ACAT1 MRPL11 NDUFA5 TIMM50 LDHB CYB5R3 RHOT1 COX11 MDH2 NDUFV2 NDUFV1 ATP5MG ATP6V1D IMMT ATP5MF COX10 ATP5ME ACADSB GLUD1 OGDH CYCS MRPS15 COX4I1 ATP5PO MRPS11 MRPS12 ETFA TCIRG1 MRPL34 CPT1A ATP5G1 COX7C SDHD MRPL35 COX5A SDHA OPA1 TIMM17A UQCRFS1 ATP6V0B MRPS22 NDUFC2 PPM2C NDUFC1 NDUFS8 BDH2 NDUFS6 PDHA1 NDUFS4 COX6C NDUFS1 SLC25A5 SLC25A12 SLC25A11 ATP6V0C ISCA1 ACADVL FXN SLC25A6 NDUFB8 NDUFB6 HCCS NDUFB5 TIMM9 NDUFB4 NDUFB3 IDH3B TIMM13 NDUFB2 DKFZp564P2062 NDUFB1 TIMM10 MRPS30 HEL-S-123m MFN2 SLC25A20 HADHB MST065 FH NDUFA9 TIMM8B COX17 HSD17B10 NDUFA7 NDUFAB1 NQO2 NDUFA6 ZNF183 NDUFA4 MTX2 NDUFA3 NDUFA2 ATP5F1D ISCU ATP5F1E LRPPRC SURF1 HTRA2 ALDH6A1 POLR2F NNT COX6A1 PHYH SDHC SDHB POR RHOT2 UQCRC1 SUCLG1 HALLMARK_HYPOXIA%MSIGDB_C2%HALLMARK_HYPOXIA HALLMARK_HYPOXIA MAP3K1 HMOX1 SLC2A3 FOS CASP6 STC1 ZNF292 DPYSL4 S100A4 CDKN1C MIF BTG1 DDIT4 PRKCA RRAGD KDELR3 SAP30 SRPX CDKN1A SLC25A1 CDKN1B SDC3 NR3C1 AK4 ATP7A HEL-S-87p CA12 HEL-S-17 TPD52 TPBG ANKZF1 RBPJ B3GALT6 EXT1 MT1E HEL-S-133P EFNA3 P4HA1 SDC2 ERRFI1 PRDX5 HEL-S-89n PIM1 PDK3 DDIT3 GYS1 CITED2 HK2 PGM2 ZFP36 VLDLR HEL-S-19 CXCR4 CP ALDOB ANXA2 ALDOC EGFR CAVIN1 F3 ATF3 HEL-S-68p GPC4 ADORA2B PFKL HEL-S-49 NFIL3 CCNG2 PFKP HEL-S-75 SERPINE1 PNRC1 ERO1A ENO2 CTGF HEL-S-278 ENO3 XPNPEP1 LOX PPP1R3C SDC4 SCARB1 ADM TES BHLHB2 JUN NDST1 MT2A KIF5A HEL-S-162eP IGFBP1 JMJD6 TPST2 BCAN STC2 ILVBL LARGE IL6 PKP1 LXN LYZG PCK1 FOXO3 B4GALNT2 CCN5 PPARGC1A PKLR KLHL24 MAFF FOSL2 EFNA1 CSPG3 TGFBI HEXA BRS3 CSRP2 STBD1 EDN2 SULT2B1 AMPD3 GCK TNFAIP3 FBP1 TMEM45A CHST3 KDM3A DGIC CYR61 NOCT HAS1 GCNT2 VHL CAVIN3 P4HA2 AKAP12 HS3ST1 NAGK ACKR3 INHA GPC3 PYGM PLAUR HEL-S-134P DCN RORA KLF6 KLF7 TIPARP SIAH2 GAA PGAM2 ANGPTL4 BCL2 BNIP3L PPP1R15A GPC1 GLRX MXI1 ADFP MYH9 HEL-S-45 VEGFA ISG20 HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY%MSIGDB_C2%HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY HALLMARK_REACTIVE_OXYGEN_SPECIES_PATHWAY ATOX1 HEL-S-128m GCLC HEL-S-2a HEL-S-112 HEL-S-97n NDUFB4 SRXN1 MGST1 MPO GCLM PTPA NQO1 SBNO2 HHEX MBP CDKN2D EGLN2 TXNRD2 OXSR1 GLRX2 ABCC1 IPCEF1 SCAF4 NDUFA6 MSRA FES SELS LAMTOR5 FTL HEL-S-44 GPX3 JUNB TXN PFKP ERCC2 PRNP GLRX GPX4 HEL-75 DKFZp564M2422 HALLMARK_TNFA_SIGNALING_VIA_NFKB%MSIGDB_C2%HALLMARK_TNFA_SIGNALING_VIA_NFKB HALLMARK_TNFA_SIGNALING_VIA_NFKB KDM6B DUSP4 PTX3 DDX58 SERPINB8 SLC2A3 FOS TUBB2A CCL20 BIRC2 B4GALT5 NFAT5 BCL2A1 CEBPD SUI1 RELB DNAJB4 G0S2 CCL4 NFKBIA LAMB3 KLF2 PER1 MARCKS SPSB1 F2RL1 TNIP2 MYC CLCF1 KLF9 TRIP10 BTG3 BTG2 BCL6 BTG1 CXCL2 CDKN1A HES1 IRF1 KLF4 PLPP3 MAP2K3 FOSB NFKB1 TANK SQSTM1 ZFP36 ABCA1 DUSP2 EHD1 F3 ATF3 KYNU DUSP5 NFIL3 CSF1 LDLR SERPINE1 CCRL2 PNRC1 TNC CEBPB ATP2B1 IL12B IL15RA TNLG5A CSF2 EBI2 SGK1 GEM TNFRSF9 PTPRE TRIB1 CXCL11 SDC4 MXD1 TNFAIP6 BHLHB2 JUN PDE4B GADD45A OLR1 INHBA LIF IL6 EDN1 CCND1 RIPK2 ID2 IFNGR2 IL18 MAFF FOSL2 GADD45B EFNA1 CXCL10 YRDC BMP2 IL1A CXCL6 PLEK IL7R TNFAIP3 CXCL1 PTGER4 AREG CYR61 IL6ST SERPINB2 RELA ETS2 ACKR3 CCL5 PLAUR TRAF1 RHOB CD83 KLF6 CD80 TMEPAI RNF19B IFIT2 CD44 PBEF1 ZC3H12A CD69 SLC16A6 TIPARP IL1B PHLDA2 MAP3K8 CCNL1 JUNB SPHK1 DENND5A IER5 IER2 PHLDA1 TAP1 IL23A TNF-alpha NINJ1 SIK1 FUT4 BIRC3 SOCS3 SNN MSC PPP1R15A EGR1 EGR2 PLK2 NFKB2 B4GALT1 FOSL1 RCAN1 NR4A3 REL PTGS2 NFKBIE NFE2L2 TNFAIP2 CXCL3 TGIF1 SLC2A6 MCL1 LITAF VEGFA FLJ11259 HBEGF IFIH1 DKFZp564M2422 PANX1 HALLMARK_INTERFERON_ALPHA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_ALPHA_RESPONSE HALLMARK_INTERFERON_ALPHA_RESPONSE PSM8 CMPK2 EIF2AK2 NMI BST2 LGALS3BP OGFR SAMD9L CXCL11 IFITM2 SELL DKFZp761B2210 ADAR IFI35 RTP4 TMEM140 IFI30 LOC93343 IFIT3 OASL NUB1 TRIM5 EPSTI1 TRIM25 TRIM26 TRIM21 GBP4 CMTR1 IRF1 HERC6 DKFZp686H0575 BATF2 WARS RSAD2 SP110 HLA-C TRAFD1 RIPK2 TENT5A PROCR OAS1 IFI27 TRIM14 PSME2 CXCL10 CD47 LGP2 IRF9 RNF31 SAMD9 IRF7 UBA7 GMPR USP18 HELZ2 SLC25A28 GBP2 CD74 PNPT1 MX1 IFI44 ISG15 TDRD7 PARP14 PARP12 LAP3 MOV10 IL7 IL15 C1S PLSCR1 IFIT2 IFITM3 IFITM1 hCG_16983 TAP1 CSF1 STAT2 UBE2L6 IRF2 LAMP3 CCRL2 TXNIP B2M CNP IFIH1 LY6E ISG20 HALLMARK_UNFOLDED_PROTEIN_RESPONSE%MSIGDB_C2%HALLMARK_UNFOLDED_PROTEIN_RESPONSE HALLMARK_UNFOLDED_PROTEIN_RESPONSE EIF4A1 TUBB2A SLC7A5 ASNS RRP9 DNAJC3 H2AX DDIT4 KDELR3 NABP1 NHP2 HEL-S-125m CEBPG NOLC1 EIF2S1 HEL-S-89n IARS GOSR2 POP4 EIF4A3 IFIT1 EDC4 RPS14 EXOSC5 TATDN2 KHSRP BANF1 CHAC1 TSPYL2 HEL-S-61 SEC31L1 IMP3 SLC30A5 DNAJB9 DKFZp434N1728 HEL-S-99n DDX10 PDIA5 ERN1 MTHFD2 DKC1 ATF3 GEMIN4 ATP6V0D1 ATF4 SHC1 BAG3 EIF4EBP1 SSR1 FUS EDEM1 EIF4E LSM1 LSM4 CNOT4 CNOT2 SRPRA HYOU1 ALDH18A1 DCP1A EIF4G1 FKBP14 CKS1B SERP1 TTC37 WIPI1 CEBPB YWHAZ DCP2 ERO1A SKIV2L2 EXOC2 CXXC1 SDAD1 DKFZp686I0746 EIF4A2 EXOSC4 EXOSC10 EXOSC1 PAIP1 NFYA NFYB DKFZp781H1925 PSAT1 NOP56 SPCS3 XPOT IGFBP1 STC2 SEC11A SPCS1 SRPRB SLC1A4 XBP1 WFS1 TARS1 VEGFA PREB HALLMARK_INTERFERON_GAMMA_RESPONSE%MSIGDB_C2%HALLMARK_INTERFERON_GAMMA_RESPONSE HALLMARK_INTERFERON_GAMMA_RESPONSE DDX58 IL10RA CASP4 PSM8 NFKBIA IRF4 LGALS3BP OGFR SAMD9L IFITM2 BTG1 ADAR IFI35 IFI30 RBCK1 IFIT3 FGL2 OASL CASP3 CDKN1A EPSTI1 TRIM25 TRIM26 TRIM21 GBP4 CMTR1 IRF1 HERC6 BATF2 WARS RSAD2 SP110 TRAFD1 IFI27 TRIM14 PSME2 LGP2 MVP IRF9 RNF31 USP18 HELZ2 SLC25A28 CD74 PNPT1 ISOC1 MX1 IFI44 ISG15 PIM1 TDRD7 PARP14 NFKB1 PARP12 LAP3 IL7 IFIT1 PLSCR1 NOD1 MTHFD2 PSMA2 RIPK1 SRI PFKP STAT2 UBE2L6 IRF2 B2M TNFSF10 IL15RA ARID5B PSMB2 MYD88 LY6E GZMA SPPL2A FPR1 PTPN6 ZBP1 IFNAR2 CMKLR1 HLA-B HIF1A HLA-A HLA-G NUP93 IDO1 CSF2RB RNF213 ST8SIA4 SLAMF7 CMPK2 ST3GAL5 HLA-DQA1 EIF2AK2 AUTS2 NMI TOR1B MHC2TA BST2 XAF1 HLA-DRB1 EIF4E3 CXCL11 SECTM1 IL18BP ITGB7 ApoL6 VAMP8 CFH RTP4 LATS2 CXCL9 OAS2 SERPING1 CD40 BANK1 TNFAIP6 OAS3 HEL-S-156an PELI1 XCL1 IRF5 VCAM1 RAPGEF6 MT2A VAMP5 PDE4B MARCHF1 PSMB10 hCG_1644110 HLA-DMA hCG_2009644 STAT4 IL6 METTL7B FCGR1A PTPN1 STAT1 RIPK2 MX2 P2RY14 STAT3 LYSMD2 ZNFX1 CXCL10 TAPBP IRF7 TNFAIP3 LCP2 SSPN ARL4A CCL7 CCL5 IL15 C1S C1R PML BPGM IL2RB IFIT2 PBEF1 CD69 IFITM3 IRF8 hCG_16983 TAP1 SOCS3 TXNIP SOCS1 PTGS2 TNFAIP2 SELP IFIH1 DKFZp564M2422 ISG20 HALLMARK_APICAL_JUNCTION%MSIGDB_C2%HALLMARK_APICAL_JUNCTION HALLMARK_APICAL_JUNCTION CLDN19 EVL CDH15 NLGN3 NLGN2 AMIGO1 AMIGO2 NEXN PARD6G NRXN2 THBS3 LIMA1 NRAP ADAM23 CTNNA1 LAMB3 MPZL1 NEGR1 BAIAP2 MAPK11 PPP2R2C TAOK2 SORBS3 ZYX NECTIN3 NECTIN2 CRB3 DBP2 NECTIN1 CLDN9 DKFZp666O0110 DKFZp434N101 CRAT IRS1 SDC3 PTEN AKT3 TMEM8B DKFZp686A1195 DKFZp781J074 HRAS INSIG1 ACTG1 PFN1 STX4A PIK3R3 EGFR MVD VAV2 SHC1 GNAI1 ICAM4 COL16A1 MDK MAPK14 SRC ACTN1 CDH6 MAPK13 GTF2F1 TNFRSF11B THY1 ADAM9 CX3CL1 VCAM1 JUP NF2 BMP1 CTNND1 LNIR DKFZp666F1010 TGFBI INPPL1 FBN1 ICAM2 HEL-S-79 HEL114 DMP1 ICAM5 CDH8 ACTG2 LAMC2 TIAL1 CLDN7 CDH4 SIRPA NRTN HEL70 SCAP2 TSC1 ACTN4 ITGB1 VWF CLDN6 CLDN5 CLDN4 ADAM15 ITGB4 CERCAM DSC1 EVA1 ITGA2 DSC3 MMP2 COL17A1 GRB7 WNK4 JAM3 MYL12B CNN2 TRAF1 PDZD3 RRAS NF1 TSPAN4 SYMPK RSU1 MYH10 SPEG MMP9 CD99 VCAN VASP CADM3 CDH11 CDSN FYB1 CADM2 PARVA ALOX15B CDK8 PTPRC ARPC2 PECAM1 CD209 LAMA3 CNTN1 COL9A1 WASL ADRA1B PKD1 SGCE TRO ACTA1 ADAMTS5 PS1TP5BP1 MADCAM1 IKBKG B4GALT1 AMH CD34 SLIT2 CAP1 MAP4K2 SYK HEL-S-20 MYH9 CALB2 hCG_2039588 RHOF KRT31 TUBG1 CLDN11 CLDN15 CLDN14 EXOC4 HALLMARK_E2F_TARGETS%MSIGDB_C2%HALLMARK_E2F_TARGETS HALLMARK_E2F_TARGETS AK2 TOP2A HMGB2 BRCA1 DKFZp686G14213 CDC20 MYC H2AX HNRPD DCLRE1B JPT1 KPNA2 NUP107 POP7 DSCC1 CCP110 WEE1 BUB1B SMC6 MKI67 SMC3 CDKN1A SMC4 PNN CDKN1B PTTG1 WDR90 CHEK2 CHEK1 hCG_37731 HMMR HUS1 ILF3 DDX39A MSH2 TIMELESS ASF1A ASF1B NOLC1 SNRPB SLBP NUP205 CDCA3 PRKDC SHMT1 CDCA8 ORC2L ZW10 PDS5B RAD51AP1 UBR7 RAD21 PA2G4 PRIM2A NASP LYAR DKFZp686O0451 BARD1 DKFZp686J1569 EIF2S1 HEL25 HMGA1 NUP153 PAICS PAN2 STAG1 KIF18B UBE2S UBE2T MXD3 SUV39H1 HEL-S-97n PSIP1 HMGB3 CTCF BRCA2 UNG CROP ING3 MYBL2 TK1 LBR POLE DEPDC1 PLK4 DLGAP5 HELLS PLK1 RFC1 EED TUBB CDKN2C SMC1A CIT MTHFD2 RNASEH2A CTPS1 MMS22L RAD51C ESPL1 CKS2 BIRC5 NAA38 PPM1D AURKB DCTPP1 PSMC3IP EXOSC8 ANP32E PPP1R8 RBBP7 E2F8 MCM5 GINS1 RRM2 MCM6 SPAG5 MCM2 CDKN2A CDC2 GINS3 PCNA GINS4 NBN ATAD2 DONSON CKS1B RPA1 MRE11A ORC6L CENPE CDK4 RAD50 PHF5A BRMS1L RQCD1 TACC3 CENPM TRA2B TRIP13 POLD2 SPC25 USP1 NOP56 H2AZ1 RANBP1 LIG1 DUT DEK CCNB2 RAN MAD2L1 POLA2 EZH2 MCM7 RFC3 RFC2 AURKA POLD3 CDKN3 SSRP1 POLE4 NUDT21 RPA3 CCNE1 TUBG1 HALLMARK_BILE_ACID_METABOLISM%MSIGDB_C2%HALLMARK_BILE_ACID_METABOLISM HALLMARK_BILE_ACID_METABOLISM RETSAT KLF1 NR1H4 IDH1 EPHX2 SLC35B2 SLC23A2 ABCD2 ABCD3 LOC51064 HEL111 HEL-S-53e PFKM LONP2 MLYCD ABCD1 DIO1 ACSL5 GNPAT PEX6 ALDH9A1 HSD17B11 PRDX5 ATXN1 ISOC1 RXRG FADS2 LCK HSD3B7 NR1i2 PEX13 ABCA1 SLC22A18 IDI1 HEL-S-44 AQP9 RXRA ABCA2 FADS1 SLC29A1 PECR SLC23A1 CYP46A1 NR3C2 NUDT12 ABCG8 PIPOX CYP27A1 CH25H SOAT2 IPLA2(GAMMA) RBP1 PEX11G ABCG4 SLC27A5 HAO1 ABCA5 ABCA6 ACSL1 ABCA9 DHCR24 ABCA8 BMP6 SULT1B1 PXMP2 SLCO1A2 TFCP2L1 PEX26T35insC CYP7B1 PEX7 NPC1 EFHC1 AGXT PAOX AKR1D1 HSD17B6 CYP7A1 OPTN GC PEX16 PEX19 HSD3B1 BBOX1 HEL-S-182mP PEX12 CYP8B1 NEDD4 DKFZp781N1972 ALDH8A1 NR0B2 SULT2B1 CROT SLC27A2 APOA1 GCLM ABCA3 FDXR PHYH AMACR HALLMARK_G2M_CHECKPOINT%MSIGDB_C2%HALLMARK_G2M_CHECKPOINT HALLMARK_G2M_CHECKPOINT TOP2A DKFZp686G14213 DMD SLC7A5 CDC20 MARCKS SNRPD1 MYC H2AX HNRPD JPT1 KPNA2 SMARCC1 SAP30 MKI67 SMC4 DKFZp686G18136 CDKN1B PTTG1 EFNA5 CHEK1 HMMR HUS1 ILF3 DDX39A NOLC1 PDS5B YTHDC1 RAD21 PRIM2A NASP BARD1 HMGA1 STAG1 UBE2S SUV39H1 HMGB3 CTCF BRCA2 MYBL2 LBR POLE HEL-S-61 PLK4 DKFZp686B0215 PLK1 CDKN2C SMC1A ATF5 DKC1 ESPL1 CKS2 CENPA CCNA2 BIRC5 STIL TFDP1 AURKB CDC6 MCM5 SLC7A1 MCM6 MCM2 CDC2 CKS1B POLS ORC6L CENPE CDK4 MAPK14 CDC45 TACC3 TRA2B GINS2 NEK2 SETD8 HIF1A H2AZ1 CDC27 CCNB2 MAD2L1 MT2A POLA2 ARID4A SMC2 RPS6KA5 CCND1 NUSAP1 FBXO5 EZH2 HMGN2 SLC38A1 KNTC2 LIG3 PRPF4B TGFB1 KNL1 TRAIP EWSR1 NCL NUP98 KIF20B CUL5 TROAP HCTP4 UBE2C CBX1 FANCC CHES1 MNAT1 NUMA1 KIF11 HOXC10 DBF4 KIF15 CHAF1A CHMP1A TNPO2 TTK SS18 RBM14 HEL-S-72p KIF23 AURKA HEL164 SFPQ RBL1 TLE3 INCENP PAFAH1B1 DTYMK SLC12A2 DKFZp666G145 PML HIST1H2BK HIRA PURA WRN KATNA1 NSD2 E2F3 E2F4 DKFZp434N181 SRSF10 CASP8AP2 H2AZ2 CDKN3 EGF CUL4A MEIS1 CENPF PRC1 E2F2 UCK2 HALLMARK_MTORC1_SIGNALING%MSIGDB_C2%HALLMARK_MTORC1_SIGNALING HALLMARK_MTORC1_SIGNALING GGA2 ABCF2 NFYC P8 SLC2A3 UFM1 CCNG1 POLR3G ADIPOR2 HEL-S-94n SLC7A5 STC1 ASNS RRP9 IDH1 BTG2 ADD3 SCD DDIT4 NMT1 IFI30 GSK3B FGL2 CTH CDKN1A UBE2D3 AK4 SLA WARS HEL-S-87p HEL-S-125m HEL-S-17 CTSC IGFBP5 DDX39A TBK1 ME1 NUP205 MAP2K3 HEL-S-133P ACTR3 CYB5B P4HA1 INSIG1 ACTR2 ELOVL6 EIF2S2 DKFZp686O0451 TMEM97 PDAP1 RDH11 HEL-S-89n TM7SF2 COPS5 FADS2 EPRS1 DDIT3 TRIB3 USO1 HK2 SC5DL STARD4 SQSTM1 HEL-S-69p UNG HMGCS1 VLDLR CXCR4 PIK3R3 YKT6 DAPP1 DKFZp686B0215 PLK1 HEL-S-99n SORD ACACA MTHFD2 M6PR IDI1 HEL-S-68p PSMA4 EGLN3 HMGCR ATP6V1D IMMT SSR1 PFKL EBP EDEM1 CANX HEL-S-49 NFIL3 ETF1 GLA RRM2 LDLR NIBAN1 MCM2 RPA1 ATP5G1 SERP1 CYP51A1 RIT1 FADS1 PLOD2 ERO1A HSPD1 ACSL3 NFKBIB HEL-75 PSAT1 DHCR24 IFRD1 PSMC6 PSMC4 HMBS HEL-S-156an ATP2A2 TES BHLHB2 HEL-S-162eP PSMG1 SEC11A GCLC SCAP2 AURKA SLC1A4 SLC9A3R1 SLC7A11 XBP1 PBEF1 PITPNB PSPH SYTL2 MTHFD2L AF1Q PSMD12 TUBA4A FKBP2 FDXR PSMD13 CFP DHCR7 PPP1R15A CORO1A HEL-S-66p SDF2L1 PNO1 HSPA4 HEL-S-283 GLRX ACLY CCT6A DHFR PHGDH CACYBP UCHL5 BCAT1 TUBG1 EEF1E1 RPN1 RAB1A TOMM40 NUFIP1 ELOVL5 HEL-S-51e HALLMARK_ALLOGRAFT_REJECTION%MSIGDB_C2%HALLMARK_ALLOGRAFT_REJECTION HALLMARK_ALLOGRAFT_REJECTION BRCA1 SPI1 LYN NCF4 UBE2D1 CXCL13 RPL9 IL27RA RPS19 CCL4 SIT1 IL12A HLA-DOA HLA-DOB IL13 RPL39 CD96 RPS9 RARS1 KRT1 IRF4 TAP2 CARTPT HLA-E CD8A AARS1 IGSF6 LTB CD79A ELANE SOCS5 CCR1 CD2 CRTAM LY86 HEL-S-71 IL2 RPL3L IL9 HLA-DRA KLRD1 DEGS1 ITK DYRK3 CD3G CD3E CD3D WARS IKBKB TPD52 MRPL3 CCR5 CCR2 IL2RA DKFZp451M2318 SRGN EIF5A IL11 CD8B1 IL16 RPS3A MAP3K7 NCR1 CD47 ZAP70 NCK1 IFNG ELF4 IFNGR1 CCL13 CCL11 MTIF2 HLA-DMB CXCR3 PRKCB CSK CCL19 GBP2 TRAF2 IL12RB1 CD74 NOS2 TRAT1 GALNT1 c-fgr LCK CD7 CD247 FCGR2B EIF3A IL7 IL2RG EGFR EIF3S1 CSF1 CDKN2A IL18RAP IL4 B2M TNFSF6 IL12B WAS ACVR2A CD1D CCND2 GZMA CD40LG PTPN6 IFNAR2 HIF1A HLA-A HLA-G HEL-S-66 EREG NLRP3 ST8SIA4 HLA-DQA1 THY1 ABCE1 CXCL9 EIF3D CD40 STAB1 C2 PSMB10 HLA-DMA INHBA STAT4 LIF IL6 IL10 STAT1 RIPK2 IFNGR2 IL18 TGFB1 TAPBP TLR1 IRF7 LCP2 TLR3 MBL2 CTSS TIMP1 ACHE F2 CCL7 HCLS1 CCL5 MAP4K1 IL15 CCL22 MMP9 GPR65 CD80 FYB1 IL2RB CCND3 IL1B PTPRC PF4 IRF8 TAP1 INHBB TNF-alpha PRF1 CFP FLNA F2R SOCS1 BCL10 BCAT1 HDAC9 HALLMARK_IL6_JAK_STAT3_SIGNALING%MSIGDB_C2%HALLMARK_IL6_JAK_STAT3_SIGNALING HALLMARK_IL6_JAK_STAT3_SIGNALING EBI3 HMOX1 IL17RB PIK3R5 CXCL13 CSF2RB CD14 IL13RA1 TNFRSF21 STAM2 IL3RA CXCL11 LTB CXCL9 CCR1 CSF2RA JUN IRF1 A2M IL6 PTPN1 STAT1 IL2RA IFNGR2 STAT3 TGFB1 OSMR CXCL10 IRF9 BAK1 IFNGR1 ITGB3 CXCL1 IL12RB1 TNFRSF1A IL6ST CNTFR PIM1 ACVR1B CCL7 ACVRL1 IL7 LEPR TNFRSF12A ITGA4 DNTT TYK2 IL17RA IL9R PDGFC HAX1 IL10RB PLA2G2A INHBE LTBR TNFRSF1B CRLF2 IL2RG CD36 CD44 IL1B MAP3K8 IL18R1 PF4 CSF1 TNF-alpha IL1R2 SOCS3 STAT2 PTPN11 SOCS1 CBL IL15RA CXCL3 GRB2 CSF2 IL1R1 MYD88 IFNAR1 HALLMARK_XENOBIOTIC_METABOLISM%MSIGDB_C2%HALLMARK_XENOBIOTIC_METABOLISM HALLMARK_XENOBIOTIC_METABOLISM RETSAT HMOX1 CASP6 EPHX1 LPIN2 VTN APOE HEL-S-21 NQO1 IDH1 CYP1A1 ABCD2 TPST1 PC ALAS1 PAPSS2 NMT1 PEMT NR1C2 AHCY ACO2 ARPP19 ALDH2 ALDH9A1 CDA ACOX1 TMEM97 TNFRSF1A CDO1 PDK4 DDT HEL-S-277 CYFIP2 SLC35B1 CNDP2 LONP1 PTGDS DKFZp686I24235 HEL-S-64p HES6 LOC283537 ENTPD5 MTHFD1 CYP2E1 EPHA2 KYNU CES1 DHRS7 ENPEP SLC35D1 SAR1B SLC22A1 GSTT2 AQP9 ABHD6 NDRG2 ADH5 TDO2 pcap TTPA ASL KARS1 CYP2J2 SERPINE1 GCKR GABARAPL1 PMM1 CYP4F2 G6PC1 DCXR ALDH3A1 CYP26A1 CYP2S1 UGDH CYP1A2 GUGU IL1R1 LEAP2 AOX1 ADH7 MAN1A1 HEL-75 ACP2 HGFAC ABCC3 ARG2 ABCC2 VNN1 DHPS SSR3 IGFBP4 CYP27A1 PTGR1 ANGPTL3 ACOX3 CRP ITIH4 DDC CYP17A1 PGRMC1 SERTAD1 HSD17B2 ATOH8 RBP4 XDH PTGES3 MARCHF6 CCL25 MPP2 AKR1C2 DHRS1 PINK1 GSTA3 ADH1C PROS1 NPC1 BPHL NR2A1 PTS HSD11B1 ATP2A2 FABP1 MT2A HEL-S-182mP PSMB10 IGFBP1 JUP ID2 RAP1GAP HRG IGF1 LR8 FBP1 TYR MBL2 GCLC CROT GCNT2 PTGES ETS2 HEL-S-10 ACOX2 ARG1 PLG GAD1 CD36 F10 F11 HEL-76 IRF8 SLC6A12 NINJ1 TEGT POR MAOA BCAT1 SMOX ELOVL5 HEL-S-51e HALLMARK_KRAS_SIGNALING_DN%MSIGDB_C2%HALLMARK_KRAS_SIGNALING_DN HALLMARK_KRAS_SIGNALING_DN NRIP2 NTF3 SLC25A23 SNCB CHRNG RIBC2 LGALS7B SLC12A3 TCF7L1 GPR3 DLK2 CACNG1 P2RX6 NR6A1 NPHS1 MYO15A YPEL1 MAGIX ASB7 RGS11 PDCD1 COQ8A BRDT KRT1 BTG2 LFNG LYPD3 COL2A1 UGT2B17 RSAD2 KRT13 IFNG PTGFR BARD1 ATP6V1B1 HSD11B2 MX1 SCGB1A1 IDUA FGF22 HEL-S-75 FGFR3 IL12B SELENOP SGK1 CD40LG IGFBP2 MEFV ABCG4 ZC2HC1C TFCP2L1 PNMT CLSTN3 ARHGDIG IRS4 PARK2 TGM1 NUDT11 VPREB1 TCL1A CAPN9 SLC16A7 DKFZp779K0533 SYNPO PDK2 CPA2 KRT4 KLK8 ENTPD7 CELSR2 CDKAL1 KRT5 THNSL2 SOX10 EDAR SCN10A PKP1 EDN1 CLPS KCNQ2 MSH5 SIDT1 CALCB CPB1 GP1BA KCNE2 CACNA1F SLC5A5 HNF1A FGGY KCNMB1 KCNN1 HEL-S-79 PRODH SLC38A3 EDN2 SPTBN2 MLL2 TFAP2B DTNB AMBN DCC ZBTB16 HTR1D HTR1B DKFZp666G172 SERPINB2 FGF16 CNTFR IL5 RYR1 AKR1B10 GDNF STAG3 H2AFY2 PCDHB1 CYP11B2 KLHDC8A GTF3C5 ARPP-21 TLX1 CD207 TNNI3 CPEB3 ZFP112 GPR19 RYR2 TENM2 THRB MAST3 SERPINA10 OXT SLC6A3 MFSD6 CCR8 EFHD1 CD80 INSL5 TSHB TAS2R4 EGF GRID2 CAMK1D PROP1 TENT5C KCND1 SPHK2 FSHB NGB COPZ2 PAX3 UPK3B WNT16 SNN ADRA2C SSTR4 MYOT TFF2 ITGB1BP2 CLDN16 CDH16 GPRC5C SLC29A3 SPRR3 HEL-S-20 ITIH3 SKIL SMPX NPY4R PLAG1 SHOX2 ALOX12B CCDC106 ABCB11 MYH7 P2RY4 VPS50 HALLMARK_MITOTIC_SPINDLE%MSIGDB_C2%HALLMARK_MITOTIC_SPINDLE HALLMARK_MITOTIC_SPINDLE BCL2L11 TOP2A HEL2 APC MARCKS ROCK1 TAOK2 TRIO KIAA0142 UXT NEDD9 PREX1 PPP4R2 CEP250 KNTC1 KIFAP3 RALBP1 DKFZp667A016 MAP1S CEP131 CSNK1D MID1 CD2AP SMC3 BCR SMC4 CLIP2 EZR LLGL1 ARL8A PIF1 FLNB PXN KIF1B KIF3B STK38L CEP72 FARP1 KIF3C MYO1E ECT2 DST MARK4 CEP110 TBCD ARHGAP29 DKFZp686M1993 HOOK3 DKFZp781J074 DKFZp566E044 ARHGAP27 SSH2 NET1 NCK1 SASS6 TUBGCP5 TUBGCP6 CNTROB MAP3K11 CEP57 ARHGAP5 ARHGAP4 SEPT9 CAPZB NCK2 TLK1 TIAM1 ARHGEF11 PLEKHG2 SHROOM1 DYNLL2 CKAP5 LATS1 ARHGAP10 PALLD CDC42EP4 BRCA2 ARHGEF3 CDC42EP2 CDC42EP1 ARHGEF2 SOS1 MAPRE1 ARF6 HEL-S-61 DLGAP5 KNS2 RABGAP1 PLK1 RFC1 STAU1 ARFGEF1 TUBD1 KATNB1 DOCK4 SMC1A CDC42 KIAA1569 FGD4 HEL-S-47e CYTH2 GEMIN4 ESPL1 FGD6 RICTOR BIRC5 PCNT WASF1 WASF2 CLASP1 DYNC1H1 RASA2 PCGF5 MID1IP1 RANBP9 MYO9B CENPJ ALMS1 RAB3GAP1 CDC2 CENPE CDC42BPA NEK2 CDC27 BIN1 CCNB2 SAC3D1 LRPPRC SYNPO RAPGEF6 NUSAP1 FBXO5 KNTC2 KIF20B HEL114 HCTP4 NUMA1 KIF11 TSC1 KIF15 ACTN4 TTK OPHN1 KIF23 AURKA INCENP PAFAH1B1 NF1 MYH10 KATNA1 DKFZp434N181 ARHGEF12 CENPF PRC1 WASL DOCK2 TUBA4A FLNA MYH9 RHOT2 SPTBN1 RHOF HALLMARK_P53_PATHWAY%MSIGDB_C2%HALLMARK_P53_PATHWAY HALLMARK_P53_PATHWAY RETSAT HMOX1 P8 FOS CCNG1 TNNI1 PDGFA EPHX1 JAG2 BAIAP2 S100A4 COQ8A BTG2 BTG1 TOB1 DDIT4 TCHH IFI30 CCP110 BAX CDKN1A ABCC5 TGFA TRAFD1 PROCR KLF4 HRAS BAK1 CDKN2B HEL-S-130P DDIT3 TRIB3 TSPYL2 STOM CYFIP2 LDHB ATF3 RAD51C ST14 PPM1D EPHA2 SFN SLC35D1 CD82 RXRA STEAP3 CDKN2A CCNK DGKA PCNA TM7SF3 RRP8 SESN1 RPL36 NUDT15 PMM1 TP63 PHLDA3 DCXR RPS12 FBXW7 IRAG2 TNLG5A DNTTIP2 CGRRF1 PRKAB1 TM4SF1 PERP RB1 MAPKAPK3 APP ANKRA2 S100A10 IHPK2 CCND2 ABHD4 CDKN2AIP NHLH2 IRAK1 ZMAT3 RPL18 CLCA2 CDK5R1 HEXIM1 PLK3 OSGIN1 H1-2 TCN2 SP1 MDM2 FGF13 MXD4 RAD9A H2AW CSRNP2 TRIAP1 IKBKAP PITPNC1 POM121 PIDD1 PTPRE HINT1 GM2A H2AFJ HSPA4L KIF13B CTSF MXD1 WDR8 XPC ZNF365 VAMP8 GPX2 APAF1 PRMT2 NOTCH1 RHBDF2 ISCU AEN AK1 SERPINB5 JUN RAP2B ABAT TRAF4 hD53 TAX1BP3 KLK8 CEBPA GADD45A HDAC3 GLS2 EI24 RPS27L NOL8 LIF SLC3A2 ADA RCHY1 SERTAD3 RAB40C EPS8L2 FOXO3 TPRKB SEC61A1 WWP1 NR1i1 BLCAP TGFB1 DEF6 SDC1 BMP2 IL1A LOH11CR2A ZBTB16 DDB2 PLXNB2 ACVR1B ITGB4 SLC7A11 CD81 SLC19A2 RNF19B CCND3 ALOX15B SPHK1 IER5 TAP1 INHBB NINJ1 FDXR PPP1R15A F2R RGS16 ERCC5 PLK2 TXNIP SOCS1 RRAD FLJ11259 HBEGF CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCIUM SIGNALING IN THE CD4+ TCR PATHWAY Calcium signaling in the CD4+ TCR pathway CSF2 CREM FASLG AKAP5 PTGS2 CABIN1 CHP1 PRKACA JUNB JUN BATF3 POU2F1 NFATC3 NFATC2 NFATC1 FOS IL2 IL4 FOSL1 FKBP1A RCAN1 IL3 CD40LG IFNG IL2RA RCAN2 CALM3 REGULATION OF NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR SMAD2 3 SIGNALING Regulation of nuclear SMAD2 3 signaling JUN FOS ATF2 CDKN1A CITED1 ITGB5 SERPINE1 LAMC1 NR3C1 MED15 SIN3B SIN3A MYC HNF4A SNIP1 AKT1 EP300 PIAS4 TGIF1 NCOA1 IL10 NCOA2 PIAS3 MEF2C TGIF2 FOXH1 TFE3 RUNX3 RUNX2 SAP30 RUNX1 AR KAT2B KAT2A RBL1 CREB1 TFDP1 NCOR1 MYOD1 IRF7 ATF3 DLX1 HDAC2 CEBPB CBFB MAX CTBP1 HDAC1 FOXG1 FOXO4 GATA3 FOXO3 FOXO1 RBBP4 GSC SAP18 RBBP7 E2F4 IGHA1 E2F5 NKX2-5 SKIL SMAD2 ZBTB17 HSPA8 SMAD4 CREBBP CDKN2B SMAD3 VDR IFNB1 ESR1 SMAD7 SKI IL5 COL1A2 CDK4 SP1 CDK2 SP3 TCF3 DCP1A IL23-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL23-MEDIATED SIGNALING EVENTS IL23-mediated signaling events IL18RAP STAT4 CCL2 IL12B JAK2 IL12RB1 STAT5A NOS2 STAT1 ITGA3 STAT3 IL18 IL19 TYK2 NFKB1 CD4 IL6 PIK3CA IL23A IL1B IL17F IL18R1 IL17A IL2 IFNG CXCL9 IL23R IL24 CXCL1 ALOX12B PIK3R1 CD3E MPO TNF RELA SOCS3 SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SUMOYLATION BY RANBP2 REGULATES TRANSCRIPTIONAL REPRESSION Sumoylation by RanBP2 regulates transcriptional repression PIAS1 HDAC1 HDAC4 RANBP2 UBE2I XPO1 SUMO1 MDM2 RANGAP1 PIAS2 RAN OSTEOPONTIN-MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%OSTEOPONTIN-MEDIATED EVENTS Osteopontin-mediated events NFKB1 PIK3CA JUN FOS ROCK2 ITGB3 ILK CDC42 MAPK8 PLAU SPP1 PIP5K1A MAPK1 ITGAV RAC1 MAPK3 VAV3 MAP3K1 GSN SYK CHUK MMP2 MMP9 RHOA MAP3K14 BCAR1 CD44 PIK3R1 RELA ALK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 SIGNALING EVENTS ALK1 signaling events GDF2 SMAD9 INHBA SMAD5 ACVR2B ACVR2A TGFBR1 TGFBR2 PPP1CA TLX2 ID1 CSNK2B ENG FKBP1A SMAD4 MAPK1 SMAD7 MAPK3 ACVRL1 BMPR2 ARRB2 ACVR1 SMAD1 TGFB1 TGFB3 CAV1 SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS REGULATED BY RET TYROSINE KINASE Signaling events regulated by Ret tyrosine kinase CREB1 RET GRB7 IRS1 SHC1 SRC PRKACA PIK3CA PXN IRS2 JUN RAP1A GRB10 HRAS PDLIM7 NCK1 GAB1 PTPN11 FRS2 GFRA1 PRKCA PTK2 DOK1 DOK4 GDNF DOK5 RASA1 DOK6 MAPK8 GRB2 SOS1 CRK SHANK3 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 SYNDECAN-1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-1-MEDIATED SIGNALING EVENTS Syndecan-1-mediated signaling events COL4A6 COL4A5 COL6A3 SDC1 HPSE FGFR4 PPIB MET FGFR3 PRKACA LAMA5 MAPK1 COL11A1 COL11A2 SDCBP MAPK3 CCL5 BSG COL1A2 FGF23 MMP7 MMP1 HGF CASK MMP9 COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL7A1 FGF19 COL6A2 COL4A4 TGFB1 COL5A2 COL6A1 COL4A3 REGULATION OF RAS FAMILY ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAS FAMILY ACTIVATION Regulation of Ras family activation CAMK2B RASGRF2 RASGRF1 RASAL1 RASGRP2 PRKCZ RASGRP1 RASGRP4 RASGRP3 LGALS3 RABGEF1 NRAS LGALS1 SYNGAP1 HRAS RRAS PLCE1 PRKCB PRKCE DAB2IP RASA4 PRKCA RASA2 NF1 KRAS RIN1 SOS2 RASA1 CALM3 GRB2 SOS1 AURORA C SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA C SIGNALING Aurora C signaling INCENP AURKC AURKB H3-3B IL4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL4-MEDIATED SIGNALING EVENTS IL4-mediated signaling events JAK2 STAT5A PIK3CA IL4 CD40LG ITGB3 PIGR SPI1 ETS1 IGHG3 IGHG1 MYB IL13RA2 MYBL1 JAK3 JAK1 IL13RA1 IL4R AKT1 ARG1 GTF3A OPRM1 FCER2 DOK2 IL10 IRF4 LTA TFF3 IGHE RETNLB CCL11 ALOX15 THY1 IL2RG CBL SOCS1 INPP5D STAT6 CCL17 SOCS5 STAT5B EGR2 HMGA1 MAPK14 PARP14 MTOR AICDA SELP CEBPB RPS6KB1 IRS1 BCL6 SHC1 FES PTPN6 BCL2L1 IRS2 CCL26 GRB2 IL5 COL1A2 SP1 COL1A1 PIK3R1 SOCS3 SHP2 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SHP2 SIGNALING SHP2 signaling JAK2 STAT1 IL6 PRKACA PIK3CA NRAS IL2 KRAS IFNG IL2RA JAK3 JAK1 RHOA IL2RG IRS1 SHC1 ARHGAP35 IGF1R KDR HRAS IL6R PDGFRB MAP2K1 GAB1 MAP2K2 PTPN11 IFNGR1 FRS2 LMO4 GAB2 NGF FRS3 LCK IL6ST RAF1 SDC2 PDGFB GNAI3 GRB2 SOS1 GNAI1 EGFR NTF4 NTF3 PAG1 NTRK1 NTRK2 ANGPT1 NOS3 BDNF EGF NTRK3 IGF1 VEGFA AFDN IL2RB TEK PIK3R1 IL2 SIGNALING EVENTS MEDIATED BY PI3K%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY PI3K IL2 signaling events mediated by PI3K MTOR PRKCZ NFKB1 RPS6KB1 SHC1 PIK3CA BCL2L1 FOXO3 PTPN11 IL2 GAB2 LCK IL2RA CALM3 GRB2 SOS1 MYB RAC1 JAK3 MYC JAK1 AKT1 IL2RB SGMS1 UGCG TERT PIK3R1 SMPD1 E2F1 HSP90AA1 RPS6 RELA BCL2 IL2RG EIF3A NOTCH-MEDIATED HES HEY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH-MEDIATED HES HEY NETWORK Notch-mediated HES HEY network RB1 CAMK2D CDKN1B AR NOTCH1 MAML2 JAK2 KDM1A MAML1 GATA6 TWIST1 NCOR1 GATA4 MYOD1 RBPJ STAT3 ASCL1 HIF1A GATA1 GHR YY1 CD4 HEY1 CTBP1 BGLAP HDAC1 HEY2 RBBP8 HES1 SPEN KDR HES6 TLE1 PARP1 GAA ARNT NCOR2 PTF1A NEUROG3 RCAN1 CREBBP MYB EP300 TCF3 NCOA1 E2F1 RUNX2 PLK1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK1 SIGNALING EVENTS PLK1 signaling events STAG2 KIF2A PRC1 GORASP1 CDK1 KIF20A KIZ SPC24 TPT1 RAB1A ERCC6L BUB1B ROCK2 AURKA CDC14B INCENP GOLGA2 CDC20 PPP1CB PPP2CA FZR1 PAK1 CCNB1 PPP2R1A CLSPN FBXO5 BTRC ECT2 BUB1 NINL CENPU NUDC BORA PPP1R12A RHOA FBXW11 ODF2 PLK1 CDC25C TUBG1 NDC80 CDC25B SGO1 TPX2 CENPE WEE1 INTEGRIN FAMILY CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN FAMILY CELL SURFACE INTERACTIONS Integrin family cell surface interactions ITGB1 ITGA3 ITGAM ITGB4 ITGA2B ITGB2 ITGAE ITGAL ITGAX ITGB8 ITGB7 ITGB6 ITGA4 ITGA2 ITGA1 ITGAD ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 ITGB3 ITGB5 ITGAV BARD1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BARD1 SIGNALING EVENTS BARD1 signaling events RBBP8 MRE11 PCNA PRKDC UBE2D3 BRCA1 UBE2L3 CSTF1 TOPBP1 NBN BARD1 XRCC6 FANCL XRCC5 FANCA FANCC FANCE FANCG FANCF RAD50 CDK2 RAD51 EWSR1 FANCD2 CCNE1 ATM TP53 ATR S1P5 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P5 PATHWAY S1P5 pathway RHOA GNAI3 GNAI1 GNAO1 GNAZ GNA12 S1PR5 GNAI2 TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY PI3K AND PLC-GAMMA Trk receptor signaling mediated by PI3K and PLC-gamma YWHAB CAMK2A AGAP2 YWHAQ CCND1 EPB41L1 SFN STAT5A CREB1 PLCG1 YWHAG YWHAH EGR1 TRPC3 PDPK1 BAD PRKCD TRPV1 SHC1 YWHAZ SRC PIK3CA CAMK4 NRAS FOXO3 HRAS GAB1 NGF KRAS GRB2 SOS1 NTRK1 AKT1 PIK3R1 YWHAE GSK3B IL12 SIGNALING MEDIATED BY STAT4%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12 SIGNALING MEDIATED BY STAT4 IL12 signaling mediated by STAT4 IL18RAP STAT4 STAT3 IL18 CD4 CD86 CD80 JUN PRF1 CD3G IL18R1 CD3D MAPK9 TBX21 IL13 FOS IL2 ETV5 IRF1 CD28 HLA-DRA PIAS2 CD247 HLA-DRB1 IFNG IL2RA MAPK8 CREBBP CD3E TGFB1 AURORA B SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA B SIGNALING Aurora B signaling KIF20A CUL3 PEBP1 AURKA CDCA8 INCENP NCAPG AURKC RASA1 KLHL13 AURKB SMC4 H3-3B CENPA NCAPH SMC2 MYLK PPP1CC RACGAP1 STMN1 EVI5 NPM1 BUB1 CBX5 SEPTIN1 NSUN2 KIF23 PPP2R5D RHOA KLHL9 PSMA3 DES NCL BIRC5 KIF2C NDC80 TACC1 NCAPD2 SGO1 VIM NETRIN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NETRIN-MEDIATED SIGNALING EVENTS Netrin-mediated signaling events NTN1 CAMK2A FYN AGAP2 YES1 UNC5A MYO10 DAPK1 UNC5B PLCG1 DCC UNC5C MAP1B ELMO1 DOCK1 SRC PIK3CA NCK1 MAP2K1 MAP2K2 PTK2 CDC42 PAK1 MAPK1 RAC1 MAPK3 RHOA BCAR1 PIK3R1 TRIO PITPNA WASL S1P4 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P4 PATHWAY S1P4 pathway CDC42 GNAI3 GNAI1 PLCG1 MAPK1 GNA13 MAPK3 S1PR4 RHOA GNAO1 GNAZ GNA12 S1PR5 GNAI2 CLASS IB PI3K NON-LIPID KINASE EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS IB PI3K NON-LIPID KINASE EVENTS Class IB PI3K non-lipid kinase events PIK3CG MAP2K1 MAPK1 PDE3B PIK3R6 C-MYB TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYB TRANSCRIPTION FACTOR NETWORK C-MYB transcription factor network HIPK2 KITLG CDKN1B CDK6 MYF6 CCND1 TAB2 TAB1 ADA GATA1 PTGS2 CD4 NRAS HES1 UBE2I KRAS CDKN1A SPI1 ETS1 CCNB1 MYB SIN3A MYC EP300 PIAS3 NCOR1 MYOD1 CEBPB SLC25A3 LECT2 CLTA YEATS4 ETS2 GATA3 PPP3CA HRAS CA1 TRIM28 CASP6 ANPEP TOM1 PIM1 RAG2 CD34 MAP3K7 PTCRA PAX5 SND1 CCNA1 HSPA8 MAF ADORA2B CREBBP KIT TFEC MCM4 PRTN3 ZFPM1 PPID MAD1L1 SKI BIRC3 CSF1R COL1A2 CEBPA COPA SP1 CEBPD LEF1 IQGAP1 NLK MAT2A WNT1 ELANE H2AZ1 ZFHX3 GSTM1 CBX4 MPO CDKN2A ATP2B1 LYZ BCL2 SMARCA2 EPHB FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHB FORWARD SIGNALING EPHB forward signaling ROCK1 ITSN1 EFNA5 KALRN EFNB2 RAP1B EFNB1 GRB7 EFNB3 EPHB2 SHC1 EPHB1 SRC EPHB4 PIK3CA PXN MAP4K4 EPHB3 NRAS RAP1A DNM1 TF HRAS SYNJ1 RRAS NCK1 MAP2K1 PTK2 KRAS RASA1 CDC42 GRB2 CRK PAK1 MAPK1 RAC1 MAPK3 PIK3R1 WASL FAS (CD95) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FAS (CD95) SIGNALING PATHWAY FAS (CD95) signaling pathway MAPK14 FASLG PDPK1 SRC PIK3CA CLTC MAPK9 FAIM2 PIK3CB IKBKB CASP8 CASP10 CASP3 RIPK1 FADD IKBKG MAP2K7 BID MAP2K6 RFC1 MAPK8 CFLAR MAPK10 MAPK11 BTK FAS EZR BIRC2 BIRC3 MAP3K1 SYK CHUK AKT1 PIK3R1 SMPD1 PLK2 AND PLK4 EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK2 AND PLK4 EVENTS PLK2 and PLK4 events PLK4 PLK2 CERAMIDE SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CERAMIDE SIGNALING PATHWAY Ceramide signaling pathway RB1 CYCS NSMAF BAD PRKCZ PRKCD NFKB1 MAP4K4 MAP2K1 MAP2K2 CASP8 RIPK1 FADD BID RAF1 MAPK8 MAPK1 MAPK3 BIRC3 ASAH1 MAP3K1 PDGFA MYC SMPD3 EGF BAG4 AIFM1 AKT1 IGF1 CTSD EIF2A MAP2K4 KSR1 CRADD SPHK2 PAWR SMPD1 EIF2AK2 TRAF2 TNFRSF1A TNF PRKRA RELA MADD BCL2 BAX ATYPICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATYPICAL NF-KAPPAB PATHWAY Atypical NF-kappaB pathway LCK BCL3 REL MAPK14 BTRC NFKB1 SYK SRC PIK3CA PIK3R1 ARRB2 IKBKB RELA ALPHA-SYNUCLEIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA-SYNUCLEIN SIGNALING Alpha-synuclein signaling FYN YES1 PRKN BLK MAOB PARK7 PLD1 SLC6A3 KLK6 PLD2 UCHL1 GRK5 BAD SNCA PRKCD LYN TOR1A SRC CSNK2A1 SNCAIP FGR HCK TH STUB1 PLCB2 FKBP1A LCK UBE2L3 SYK PPP2R5D SIGNALING EVENTS MEDIATED BY PTP1B%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PTP1B Signaling events mediated by PTP1B JAK2 STAT5A STAT3 TYK2 PIK3CA ITGB3 AKT1 RHOA BCAR1 CAV1 FYN YES1 BLK STAT5B ITGA2B IRS1 LYN SHC1 SRC FGR HCK CSF1 PDGFRB PRL YBX1 CSN2 CDH2 LEPR CAPN1 PRLR DOK1 LCK TXN INS CSK PTPN1 PDGFB INSR FER GRB2 FCGR2A CRK EGFR TRPV6 LEP SPRY2 NOX4 LAT CSF1R EGF PIK3R1 SOCS3 RHOA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RHOA SIGNALING PATHWAY RhoA signaling pathway SLC9A3 MYL2 CDKN1B PKN2 PKN1 TLN1 VCL F2RL2 ROCK1 PLD1 ITGB1 PLD2 PRKCZ JUN FOS ROCK2 MAP2K6 CDC42 ATF2 MAPK8 PIP5K1A EZR SRF PTEN SLC9A1 PARD6A CFL1 PIP5K1B PIP5K1C CCN1 SH3GL2 PPP1R12A RHOA SCAI MAP2K4 MAP2K3 LIMK2 LIMK1 RDX MSN MRTFA MAPK12 CIT ACTA1 DIAPH1 SYNDECAN-2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-2-MEDIATED SIGNALING EVENTS Syndecan-2-mediated signaling events FGFR4 CXCL8 TNFRSF13B FGFR3 ITGB1 EPB41 CSF2 LAMA1 LAMA3 KNG1 RACK1 CAV2 PRKCD EPHB2 TRAPPC4 FN1 SRC PRKACA ITGA2 HRAS CASP3 NF1 SDC2 RASA1 MAPK8 MAPK1 EZR SDCBP MAPK3 FGF23 MMP2 CASK RHOA FGF19 TGFB1 BAX RAS SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAS SIGNALING IN THE CD4+ TCR PATHWAY Ras signaling in the CD4+ TCR pathway RAF1 MAPK1 MAPK3 BRAF ELK1 MAP3K8 NRAS PTPN7 HRAS MAP2K1 PRKCB FOS PRKCA KRAS ATF-2 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATF-2 TRANSCRIPTION FACTOR NETWORK ATF-2 transcription factor network RB1 CCND1 CXCL8 NOS2 IL6 JUNB IL23A JUN HES1 HRK POU2F1 ACHE CSRP2 MAPK9 DUSP10 KAT5 FOS RUVBL2 DUSP5 PDGFRA DUSP1 DUSP8 NF1 SERPINB5 CCNA2 CUL3 IFNG DDIT3 JDP2 MACROH2A1 PPARGC1A ATF2 MAPK8 TGFB2 PLAU JUND HBG2 MAPK11 COL24A1 MAPK1 GADD45A SELE MAPK3 ARG1 MMP2 EP300 CREB1 MAPK14 ATF3 CBFB BCL2L1 TH PRKCA INS BRCA1 ESR1 CDK4 BCL2 SOCS3 EPHA FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA FORWARD SIGNALING EPHA forward signaling CBL FYN YES1 BLK ROCK1 PLCG1 EFNA5 PIK3R6 LYN PIK3CG SRC FGR HCK LCK CRK CRKL EPHA5 VAV3 EPHA4 EPHA7 EPHA6 ARHGEF15 EPHA8 VAV2 EFNA1 RHOA EFNA3 EFNA2 CDK5 EPHA1 EPHA3 NGEF EPHA2 SIGNALING EVENTS MEDIATED BY HDAC CLASS I%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS I Signaling events mediated by HDAC Class I STAT3 GATA1 NFKB1 YY1 PRKACA HDAC4 RANBP2 UBE2I XPO1 SUMO1 NCOR2 RANGAP1 RAN SIN3B BTRC SIN3A EP300 HDAC10 HDAC11 TNFRSF1A CHD4 CHD3 MBD3L2 SMG5 SAP30 PRMT5 SIRT4 SIRT5 KAT2B SIRT6 SIRT7 SIRT1 SIRT2 SIRT3 NCOR1 WDR77 PPARG FKBP3 HDAC5 HDAC2 HDAC3 HDAC8 GATA2 MAX HDAC9 NR2C1 HDAC1 HDAC6 HDAC7 MTA2 MBD3 SMURF1 MBD2 RBBP4 GATAD2B GATAD2A SAP18 TFCP2 RBBP7 MXD1 CREBBP ZFPM1 SMAD7 TNF RELA FOXO FAMILY SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXO FAMILY SIGNALING FoxO family signaling YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH FASLG YWHAZ MAPK9 IKBKB XPO1 RAN MAPK8 MAPK10 CCNB1 GADD45A CHUK AKT1 EP300 PLK1 KAT2B SIRT1 BCL6 FOXO4 FOXO3 FOXO1 ZFAND5 SKP2 CSNK1G3 USP7 MST1 CSNK1D CSNK1E RBL2 CAT SGK1 CREBBP CSNK1G2 CSNK1G1 RALA RALB BCL2L11 CSNK1A1 FBXO32 SOD2 G6PC1 CTNNB1 CDK2 YWHAE ARF6 TRAFFICKING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 TRAFFICKING EVENTS Arf6 trafficking events BIN1 AGTR1 EXOC4 EXOC3 CPE EXOC6 EXOC5 EXOC2 PLD1 VAMP3 ITGB1 ITGA3 EXOC1 ARF6 PLD2 ITGA4 ITGA2 ITGA1 CLTC ITGA10 ITGA11 ITGA8 ITGA7 ITGA6 ITGA5 ITGA9 INS RALA ITGAV CTNNB1 CTNND1 SLC2A4 ADRB2 PIP5K1C ASAP2 KLC1 CDH1 CTNNA1 SPAG9 EXOC7 AVPR2 MAPK8IP3 TSHR SCAMP2 NME1 DNM2 ACAP1 SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SPHINGOSINE 1-PHOSPHATE (S1P) PATHWAY Sphingosine 1-phosphate (S1P) pathway GNAI3 GNAI1 ABCC1 SPHK1 GNA13 SGPP1 S1PR4 GNA14 SGPL1 GNA15 GNAQ GNA11 S1PR1 S1PR3 S1PR2 SPHK2 GNAO1 GNAZ GNA12 S1PR5 GNAI2 CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS MEDIATED BY AKT Class I PI3K signaling events mediated by Akt YWHAB CDKN1B YWHAQ SFN YWHAG YWHAH MTOR PDPK1 BAD YWHAZ SRC PRKACA BCL2L1 FOXO4 GSK3A FOXO3 MAPKAP1 FOXO1 CASP9 AKT2 AKT3 MLST8 RICTOR KPNA1 MAP3K5 TBC1D4 PRKDC RAF1 CDKN1A SLC2A4 CHUK AKT1 HSP90AA1 YWHAE GSK3B E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN THE NASCENT ADHERENS JUNCTION E-cadherin signaling in the nascent adherens junction CCND1 ARF6 RAP1B ITGAE SRC PIK3CA ITGB7 RAP1A CYFIP2 NCKAP1 WASF2 AP1M1 CDC42 JUP KLHL20 TJP1 ENAH CRK TIAM1 DLG1 CTTN RAC1 ABI1 RAPGEF1 CTNNB1 CTNND1 AKT1 PIP5K1C VAV2 IQGAP1 RHOA AFDN CDH1 CTNNA1 PIK3R1 NME1 SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY THE HEDGEHOG FAMILY Signaling events mediated by the Hedgehog family TGFB2 LRPAP1 STIL DHH PTCH1 HHIP PIK3CA PTCH2 AKT1 IHH LRP2 PTHLH GLI2 HHAT SHH GRK2 PIK3R1 ARRB2 SMO BOC GAS1 CDON POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POLO-LIKE KINASE SIGNALING EVENTS IN THE CELL CYCLE Polo-like kinase signaling events in the cell cycle PLK1 PLK4 PLK2 PLK3 VISUAL SIGNAL TRANSDUCTION: CONES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: CONES Visual signal transduction: Cones GUCY2D PDE6H GUCA1B GUCA1A GUCA1C ARR3 GUCY2F RPE65 GRK1 GNGT2 GNAT2 RDH12 RGS9BP GRK7 PDE6C GNB3 CNGB3 RDH5 LRAT CNGA3 GNB5 RGS9 SLC24A2 RAC1 SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAC1 SIGNALING PATHWAY RAC1 signaling pathway STAT5A STAT3 JUN MAPK9 CYFIP2 NCKAP1 MAP2K7 WASF2 MAP2K6 ATF2 MAPK8 PAK1 PIP5K1A RAC1 RACGAP1 ABI1 MAP3K1 MAP2K4 BCAR1 MAPK14 NCF1 NCF2 PLCB2 ARPC1B BRK1 ARHGAP5 ARHGDIA ACTR3 ACTR2 CYBB CYBA NOXO1 IQGAP3 WASF1 PAK2 ARPC4 ARPC5 BAIAP2 CRK ABI2 ARPC2 ARPC3 NOXA1 MAP3K11 NOX1 CTNNB1 CFL1 PIP5K1B PIP5K1C IQGAP1 CDH1 MAP2K3 CTNNA1 LIMK1 REGULATION OF CDC42 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CDC42 ACTIVITY Regulation of CDC42 activity ARHGEF7 ARHGEF6 PLCG1 ITSN1 ARHGDIA CDC42 RACGAP1 ITSN2 VAV3 BCAR3 DOCK6 DOCK9 ARHGEF25 ARHGAP1 VAV2 ARHGAP17 FGD1 DOCK10 DOCK11 MCF2L GIT1 FARP2 NGEF RALBP1 MCF2 ARHGEF9 NME1 DNMBP APC SPATA13 HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-2-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-2-alpha transcription factor network FLT1 EPO CITED2 EPAS1 SLC2A1 SIRT1 PGK1 TWIST1 ELOB HIF1AN VHL ELOC EGLN1 EGLN3 EGLN2 SLC11A2 POU5F1 MMP14 ELK1 ADORA2A APEX1 BHLHE40 EIF3E KDR FXN ABCG2 ARNT CREBBP ETS1 SERPINE1 SP1 EP300 VEGFA EFNA1 REGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF ANDROGEN RECEPTOR ACTIVITY Regulation of Androgen receptor activity PKN1 EGR1 RACK1 JUN POU2F1 EHMT2 KAT5 ZMIZ2 TRIM24 KAT7 SMARCC1 MDM2 SENP1 PDE9A TMPRSS2 KLK3 KLK2 RCHY1 HOXB13 MAP2K6 NR2C2 RXRB MAPK8 RXRA SRY RXRG SPDEF SMARCE1 NR3C1 NR0B1 DNAJA1 APPBP2 CARM1 EP300 MAP2K4 NCOA1 NCOA2 AR KAT2B REL SIRT1 MAPK14 GATA2 SRC NR2C1 HDAC1 HDAC7 FOXO1 CREBBP CEBPA HSP90AA1 GSK3B SMARCA2 PDGFR-ALPHA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-ALPHA SIGNALING PATHWAY PDGFR-alpha signaling pathway GRB2 SOS1 PLCG1 CRK ITGAV CRKL SRF RAPGEF1 CAV3 JAK1 SHC1 SHB CSNK2A1 SHF PIK3CA ELK1 JUN FOS PIK3R1 PDGFRA CAV1 SYNDECAN-3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-3-MEDIATED SIGNALING EVENTS Syndecan-3-mediated signaling events FYN FGFR4 CXCL8 EGFR FGFR3 CTTN FGF23 SRC PSENEN NCAN CASK SDC3 PSEN1 PTN POMC APH1A MC4R NCSTN FGF19 APH1B AGRP SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-ALPHA AND P38-BETA Signaling mediated by p38-alpha and p38-beta RPS6KA4 ELK4 RPS6KA5 MKNK1 EIF4EBP1 EIF4E MEF2A CREB1 NOS2 KRT8 PLA2G4A MITF MAPK14 USF1 KRT19 MAPKAPK3 MAPKAPK2 CEBPB PTGS2 HBP1 MAPKAPK5 ATF6 RAB5A JUN DDIT3 PPARGC1A ATF2 MAPK11 ESR1 SLC9A1 TP53 MEF2C ATF1 GDI1 HSPB1 ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA4 BETA1 INTEGRIN SIGNALING EVENTS Alpha4 beta1 integrin signaling events TLN1 ITGB1 ARF6 DOCK1 FN1 YWHAZ SRC PRKACA IGSF8 PXN CD81 THBS2 ITGA4 THBS1 ADAM28 MDK CD14 PRKACB JAM2 VCAM1 MYH2 JAML PTK2 PRKAR1B PTPRA PRKAR1A SPP1 CRK RAC1 ABI1 BCAR1 GIT1 WNT SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%WNT SIGNALING NETWORK Wnt signaling network LRP5 FZD10 LRP6 WIF1 RSPO1 WNT2 WNT3 CTHRC1 FZD1 FZD2 FZD5 IGFBP4 RYK FZD4 WNT3A WNT7B FZD7 ATP6AP2 WNT5A FZD6 FZD9 WNT1 KREMEN1 WNT7A FZD8 KREMEN2 DKK1 ROR2 AP-1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AP-1 TRANSCRIPTION FACTOR NETWORK AP-1 transcription factor network NPPA TIMP1 CDKN1B EDN1 CCL2 HLA-A CCND1 ELF1 DMTF1 NTS CXCL8 PENK BAG1 TCF7L2 CSF2 EGR1 AGT FOSL2 HIF1A FABP4 COPS5 MAFG TRIP6 IL6 FOSB JUNB JUN NFATC3 NFATC2 NFATC1 FOS IL2 IL4 FOSL1 DUSP1 IFNG ATF2 PLAU JUND ETS1 NR3C1 MYB MYC EP300 MMP9 IL10 TGFB1 CDK1 CREB1 ATF3 CBFB GATA2 TH MAF BCL2L11 ESR1 PTEN IL5 COL1A2 CTNNB1 SP1 MMP1 CCN1 TP53 CRTC1 CDKN2A DMP1 MT2A ACTA1 GJA1 INTEGRIN-LINKED KINASE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRIN-LINKED KINASE SIGNALING Integrin-linked kinase signaling ARHGEF7 ARHGEF6 CCND1 CREB1 RUVBL1 PXN NCK2 TNS1 JUN ILKAP GIT2 PPP1R14A PPP1R14B PPP1R14C PARP1 ACTN1 XPO1 RUVBL2 RHOG PARVA RICTOR PARVB CKAP5 ZEB1 PARVG NACA AURKA CDC37 SNAI1 ILK ZYX CDC42 TACC3 ELMO2 MYL9 LIMS2 LIMS1 RAC1 CTNNB1 AKT1 IQGAP1 PPP1R12A HSP90AA1 GSK3B DIAPH1 IL5-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL5-MEDIATED SIGNALING EVENTS IL5-mediated signaling events JAK2 GRB2 STAT5A STAT5B CISH IL5RA CSF2RB SDCBP IL5 LYN PIK3CA PTPN11 PIK3R1 PIM1 RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RXR AND RAR HETERODIMERIZATION WITH OTHER NUCLEAR RECEPTOR RXR and RAR heterodimerization with other nuclear receptor PPARG RPS6KB1 NCOR2 RXRB RXRA RXRG VDR RARG THRB THRA FAM120B ABCA1 SREBF1 MED1 NR1H2 NR1H4 NR1H3 NCOA1 NR4A1 RARA RARB PPARA TNF TGFB1 BCL2 N-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%N-CADHERIN SIGNALING EVENTS N-cadherin signaling events AXIN1 GAP43 MYL2 MAPRE1 DAGLB FGFR1 ROCK1 PLCG1 PIK3CA PTPN11 CDH2 LRP5 PTPN1 CDC42 JUP CALM3 MAPK8 FER CTTN RAC1 GSN CTNNB1 CTNND1 PIP5K1C RHOA CTNNA1 GRIA2 PIK3R1 DAGLA DCTN1 CNR1 KIF5B GJA1 CAMK2G P63 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P63 TRANSCRIPTION FACTOR NETWORK p63 transcription factor network TP63 VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR ALPHA NETWORK Validated nuclear estrogen receptor alpha network CCND1 STAT5A JUN HDAC4 NCOR2 NR0B1 MYC CHUK MED1 EP300 CTSD NCOA1 NCOA2 COL18A1 CALCOCO1 CD82 NCOR1 MPG SRA1 PHB2 DDX17 PDIA2 DSCAM CEBPB NCOA3 AP1B1 DDX54 AXIN2 HDAC1 SAFB LCOR PGR TRIM59 TFF1 NCOA7 PRL SET ANP32A PRDM15 LMO4 NEDD8 C3 MTA1 HSF2 PCNA NRIP1 VTLGL1 APBB1 BRCA1 NDUFV3 ATP5PF SMAD4 XBP1 KLRC3 ABCA3 GREB1 NR0B2 ESR1 POU4F1 ESR2 POU4F2 SOD1 UBA3 EBAG9 UBE2M SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY FOCAL ADHESION KINASE Signaling events mediated by focal adhesion kinase ARHGEF7 CCND1 TLN1 VCL PLCG1 RAP1B PIK3CA BRAF NCK2 JUN GIT2 MAPK9 RRAS ACTN1 ROCK2 MAPK8 ITGB5 ETS1 PAK1 MAPK1 ITGAV RAC1 RAPGEF1 RHOA MAP2K4 BCAR1 WASL FYN YES1 ITGB1 ELMO1 DOCK1 GRB7 SRC PXN ARHGAP35 RAP1A NCK1 MAP2K1 ITGA5 PTK2 RAF1 RASA1 GRB2 SOS1 CRK PTPN21 CAPN2 SH3GL1 ARHGEF11 ARHGEF28 ASAP1 ARHGAP26 BMX KLF8 MAPK8IP3 PIK3R1 ACTA1 DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DOWNSTREAM SIGNALING IN NAIVE CD8+ T CELLS Downstream signaling in naive CD8+ T cells TNFRSF4 B2M STAT4 EOMES IFNAR2 HLA-A IFNA13 IFNA14 IFNA16 TNFRSF18 IFNA17 CD8B CD8A EGR1 PRKCQ FASLG IFNA10 IFNAR1 IFNA21 EGR4 TNFRSF9 GZMB BRAF ELK1 JUNB JUN PRF1 NRAS PTPN7 CD3G CD3D NFATC3 MAPK9 NFATC2 NFATC1 PRKCB FOS PRKCE IL2 FOSL1 CD247 KRAS IFNG IL2RA CALM3 MAPK8 MAPK1 MAPK3 IL2RG HRAS MAP2K1 MAP2K2 PRKCA RAF1 IL2RB IFNA5 IFNA4 CD3E IFNA7 IFNA6 TNF IFNA2 IFNA8 ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ANGIOPOIETIN RECEPTOR TIE2-MEDIATED SIGNALING Angiopoietin receptor Tie2-mediated signaling AGTR1 ELF1 STAT5A NFKB1 FN1 PIK3CA FGF2 ELK1 GRB14 F2 ELF2 PLG ANGPT4 ANGPT2 TNIP2 MAPK8 CDKN1A ETS1 PAK1 MAPK1 RAC1 MAPK3 AKT1 MMP2 DOK2 FYN STAT5B ITGB1 MAPK14 PLD2 GRB7 RPS6KB1 SHC1 FES PXN FOXO1 NCK1 PTPN11 ITGA5 PTK2 RASA1 GRB2 CRK ANGPT1 NOS3 TEK BMX PIK3R1 TNF RELA VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF DELTANP63 ISOFORMS Validated transcriptional targets of deltaNp63 isoforms RUNX1 NOTCH1 TP63 SFN ADA ITGA3 FOSL2 RACK1 HBP1 HES1 YAP1 TOP2A DLX5 MDM2 STXBP4 RRAD MRE11 DLX6 BRCA2 TBXT SEC14L2 CCNB2 PERP BDKRB2 HELLS GPX2 TCF7L1 VDR FBXW7 IGFBP3 ADRM1 PPP2R5A WWP1 NRG1 KRT5 POU2F2 CEBPD IL1A ITCH AXL FASN KRT14 RAB38 ATM COL5A1 CDKN2A GSK3B FANCONI ANEMIA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FANCONI ANEMIA PATHWAY Fanconi anemia pathway RFC5 FANCI RFC3 RFC4 FANCM RMI1 RFC2 TOP3A XRCC3 RPA1 RPA2 HUS1 FANCB PALB2 UBE2T RAD17 RAD1 FAN1 CENPS RAD9A HES1 MRE11 BRCA2 BRCA1 TOPBP1 NBN FANCL FANCA BTRC FANCC FANCE FANCG FANCF RAD50 FANCD2 FBXW11 ATM H2AX BLM ATR WDR48 FAAP24 BRIP1 CHEK1 USP1 ATRIP FAAP100 ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA6 BETA4 INTEGRIN-LIGAND INTERACTIONS Alpha6 beta4 integrin-ligand interactions LAMA2 LAMB3 LAMB2 LAMC2 LAMB1 LAMA5 LAMA1 LAMC1 ITGB4 LAMA3 ITGA6 CASPASE CASCADE IN APOPTOSIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CASPASE CASCADE IN APOPTOSIS Caspase cascade in apoptosis GZMB PRF1 CASP9 PARP1 CASP8 CASP10 CASP3 RIPK1 BID BIRC2 MAP3K1 GSN SREBF1 CRADD TRAF2 TNFRSF1A VIM MADD BAX CYCS APP CASP6 NUMA1 LMNB2 LMNB1 PIDD1 CASP7 PTK2 SLK CFL2 ARHGDIB CASP4 CASP1 CASP2 SPTAN1 DFFB DFFA APAF1 GAS2 TOP1 SATB1 DIABLO BIRC3 XIAP LMNA CRMA TFAP2A KRT18 LIMK1 TNF ACTA1 BCL2 IL8-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8-MEDIATED SIGNALING EVENTS IL8-mediated signaling events CXCL8 AMB2 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AMB2 INTEGRIN SIGNALING amb2 Integrin signaling TLN1 ROCK1 ITGAM RAP1B ITGB2 SELP NFKB1 IL6 RAP1A HCK PLG JAM2 MYH2 MST1 PLAU SELPLG MMP2 LRP1 MMP9 PLAT RHOA HMGB1 MST1R AGER ICAM1 CCN2 APOB JAM3 PLAUR TNF LPA THY1 REGULATION OF RAC1 ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RAC1 ACTIVITY Regulation of RAC1 activity EPS8 ARHGEF7 PREX2 ARHGEF6 ABR PREX1 CHN2 CHN1 DEF6 VAV1 BCR TIAM2 RASGRF2 KALRN ELMO1 ARHGEF2 RASGRF1 DOCK2 DOCK1 ARHGDIA SOS1 TIAM1 RACGAP1 RAC1 ABI1 VAV3 DOCK6 ARHGEF25 ARHGAP1 VAV2 ARHGAP17 NGEF RALBP1 MCF2 TRIO ARHGAP9 RAP1GDS1 SPATA13 ARF6 DOWNSTREAM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway PLD1 TIAM1 PIP5K1A MAPK1 KALRN ARF6 PLD2 RAC1 ARF1 MAPK3 RAB11A RAB11FIP3 RHOA PLAUR NME1 S1P3 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P3 PATHWAY S1P3 pathway FLT1 JAK2 GNA13 GNA14 CXCR4 GNA15 SRC GNAQ GNA11 S1PR3 PDGFRB AKT3 PDGFB GNAI3 GNAI1 MAPK1 RAC1 MAPK3 AKT1 VEGFA RHOA GNAO1 GNAZ GNA12 GNAI2 FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FC-EPSILON RECEPTOR I SIGNALING IN MAST CELLS Fc-epsilon receptor I signaling in mast cells VAV1 PLCG1 SPHK1 NFKB1 ITK WIPF1 PIK3CA CBLB FCER1A S1PR1 JUN FCER1G LAT2 HCLS1 LCP2 NFATC2 MS4A2 PRKCB FOS PLPP1 IKBKB PLA2G1B KLRG1 PTPN13 DUSP1 FCGR2B IKBKG MAP2K7 MAPK8 BTK MAPK1 MAPK3 MAP3K1 SYK CHUK AKT1 MAP2K4 IGHE CBL FYN INPP5D PLA2G4A PLD2 LYN SHC1 PXN HRAS MAP2K1 MAP2K2 PTPN11 GAB2 PTK2 DOK1 RAF1 RASA1 PAK2 FER GRB2 SOS1 LAT PIK3R1 RELA A4B7 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A4B7 INTEGRIN SIGNALING a4b7 Integrin signaling PXN ITGB7 ITGA4 RHOA ITGB1 VCAM1 MADCAM1 PTK2 NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEUROTROPHIC FACTOR-MEDIATED TRK RECEPTOR SIGNALING Neurotrophic factor-mediated Trk receptor signaling CCND1 PLCG1 STAT3 RASGRF1 RAP1B PRKCZ PIK3CA DNM1 NRAS RHOG PRKCI KRAS DYNLT1 MATK SQSTM1 FAIM SHC2 CDC42 SHC3 RGS19 MAGED1 TIAM1 NEDD4L ABL1 MAPK1 NGFR CRKL RAC1 ARHGAP32 RAPGEF1 MAPK3 RIT1 EHD4 RIT2 GIPC1 DNAJA3 RHOA ELMO1 DOCK1 SHC1 RAP1A HRAS MAP2K1 GAB1 PTPN11 FRS2 GAB2 NGF FRS3 RASA1 GRB2 SOS1 CRK NTF4 NTF3 NTRK1 NTRK2 BDNF NTRK3 MCF2L PIK3R1 CLASS I PI3K SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CLASS I PI3K SIGNALING EVENTS Class I PI3K signaling events FYN INPP5D YES1 BLK PLCG1 ARF6 ARF1 PDPK1 PIK3R6 LYN ITK PIK3CG SRC PIK3CA FGR NRAS RAP1A HCK FOXO3 HRAS PIK3CB KRAS LCK SGK1 BTK RAC1 LAT PTEN SYK INPPL1 DAPP1 CYTH3 CYTH2 RHOA PLCG2 BLNK CYTH1 PLEKHA1 PLEKHA2 PIK3R1 ARAP3 ADAP1 HSP90AA1 ZAP70 ARF5 ERBB4 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB4 SIGNALING EVENTS ErbB4 signaling events LRIG1 FYN WWOX NRG2 CBFA2T3 JAK2 GRIN2B TAB2 EREG STAT5A STAT5B BTC ADAM17 NCOR1 NRG3 NRG4 DLG4 NEDD4 HBEGF SHC1 PIK3CA PRL PIK3CB YAP1 MDM2 PRLR GRB2 MAPK1 MAPK3 WWP1 NRG1 ITCH PIK3R1 ERBB4 ERBB2 GMCSF-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GMCSF-MEDIATED SIGNALING EVENTS GMCSF-mediated signaling events INPP5D CCL2 JAK2 STAT5A STAT5B STAT1 CSF2 STAT3 CSF2RA PRKACG LYN OSM SHC1 YWHAZ IRF8 PRKACA PIK3CA NRAS HRAS PRKACB MAP2K1 FOS IKBKB MAP2K2 PTPN11 PIM1 GAB2 KRAS RAF1 GRB2 SOS1 MAPK1 CISH CSF2RB MAPK3 SYK PIK3R1 SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING MEDIATED BY P38-GAMMA AND P38-DELTA Signaling mediated by p38-gamma and p38-delta EEF2K MAP3K20 PKN1 MAPT MAP2K6 CCND1 SNTA1 MAPK13 MAP2K3 STMN1 MAPK12 STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%STABILIZATION AND EXPANSION OF THE E-CADHERIN ADHERENS JUNCTION Stabilization and expansion of the E-cadherin adherens junction MYL2 EXOC4 EXOC3 VCL ROCK1 MET ARF6 IGF1R AQP5 LPP AQP3 NCK1 LIMA1 ACTN1 MYO6 MGAT3 STX4 VASP PLEKHA7 CAMSAP3 CYFIP2 KIFC3 NCKAP1 NECTIN2 ZYX EGFR ENAH ABI1 CTNNB1 CTNND1 EGF PIP5K1C HGF IGF1 EFNA1 RHOA AFDN CDH1 CTNNA1 GIT1 EPHA2 DIAPH1 SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY VEGFR1 AND VEGFR2 Signaling events mediated by VEGFR1 and VEGFR2 FLT1 VCL ROCK1 PLCG1 ARF1 PDPK1 PRKCD PRKACA PIK3CA BRAF NCK2 PRKCB ITGB3 MAP2K6 CDC42 CALM3 MAPK11 MAPK1 ITGAV MAPK3 SHB AKT1 RHOA FBXW11 CAV1 CBL FYN MAPK14 NEDD4 MAPKAPK2 FES SRC PTPN6 PXN GRB10 KDR NCK1 MAP2K1 GAB1 MAP2K2 PTPN11 PRKCA PTK2 HSP90AB1 RAF1 PTPRJ PAK2 CDH5 MYOF GRB2 HGS SH2D2A CAMKK2 AKAP1 VTN PTPN2 NOS3 CTNNB1 IQGAP1 VEGFA MAP2K3 CTNNA1 PIK3R1 HSP90AA1 DNM2 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL ACTIVATION Validated targets of C-MYC transcriptional activation SHMT1 RPL11 ODC1 TAF9 IREB2 CDCA7 SLC2A1 MTDH HSPD1 PRDX3 LDHA MYCT1 PDCD10 PMAIP1 E2F3 TAF12 HSPA4 TAF10 RUVBL1 HUWE1 KIR3DL1 EIF2S1 LIN28B GPAM POLR3D ID2 RIOX2 KAT5 NDUFAF2 RUVBL2 TAF4B SERPINI1 FOSL1 PFKM EIF4G1 SNAI1 CCNB1 NPM1 MYC EP300 MMP9 NCL BIRC5 BAX KAT2A EIF4E HMGA1 MAX PIM1 MTA1 SMAD4 CREBBP NBN SMAD3 EIF4A1 TFRC TRRAP ENO1 CDK4 BMI1 CCND2 PEG10 UBTF RCC1 TK1 DDX18 CAD TP53 ACTL6A NME2 TERT CDC25A SUPT7L HSP90AA1 SUPT3H NME1 BCAT1 GAPDH PTMA REGULATION OF P38-ALPHA AND P38-BETA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF P38-ALPHA AND P38-BETA Regulation of p38-alpha and p38-beta FYN YES1 BLK TAB1 MAPK14 LYN SRC FGR HCK DUSP10 DUSP1 DUSP16 RIPK1 DUSP8 PAK3 PRKG1 LCK MAP3K3 TRAF6 PAK2 MAP2K6 CCM2 CDC42 MAP3K12 MAPK11 RALA PAK1 RALB RAC1 MAP2K4 MAP2K3 SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY STEM CELL FACTOR RECEPTOR (C-KIT) Signaling events mediated by Stem cell factor receptor (c-Kit) KITLG EPO JAK2 STAT5A VAV1 STAT1 STAT3 PDPK1 BAD PIK3CA MATK PTPRO MAPK8 PIK3C2B SPRED2 SPRED1 GRAP2 MAP4K1 CRKL STAP1 SH2B3 MAPK3 SH2B2 EPOR TEC SNAI2 AKT1 CBL SOCS1 MITF RPS6KB1 LYN SHC1 PTPN6 GRB10 HRAS FOXO3 MAP2K1 GAB1 MAP2K2 PTPN11 DOK1 RAF1 CREBBP FER GRB2 KIT SOS1 PTEN PIK3R1 BCL2 GSK3B GLYPICAN 3 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 3 NETWORK Glypican 3 network PTCH1 BMP4 FGF7 GPC3 FURIN MAPK8 MAPK9 SHH ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHA9 BETA1 INTEGRIN SIGNALING EVENTS Alpha9 beta1 integrin signaling events PAOX NOS2 ITGB1 CSF2 CSF2RA FN1 SRC PXN VCAM1 ITGA9 SPP1 RAC1 VEGFA TNC F13A1 BCAR1 SAT1 TGM2 KCNJ15 VEGFC VEGFD ADAM2 ADAM15 ADAM12 ADAM8 DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DNA-PK PATHWAY IN NONHOMOLOGOUS END JOINING DNA-PK pathway in nonhomologous end joining DCLRE1C PRKDC XRCC4 POLM PNKP LIG4 DNTT APTX APLF XRCC6 POLL NHEJ1 XRCC5 SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET)%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HEPATOCYTE GROWTH FACTOR RECEPTOR (C-MET) Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) F2RL2 MET PLCG1 ARF6 EGR1 PDPK1 RAP1B BAD PRKCZ PIK3CA NCK2 JUN AKT2 MLST8 PRKCI SNAI1 CDC42 MAPK8 ETS1 PAK1 MAPK1 CRKL RAC1 RAPGEF1 MAPK3 MAP3K1 INPPL1 AKT1 RHOA MAP2K4 BCAR1 WASL CBL INPP5D EIF4EBP1 EIF4E SH3KBP1 MTOR RPTOR DEPTOR AKT1S1 NUMB ARHGEF4 SHC1 RIN2 SRC RAB5A KPNB1 PXN EPS15 RAP1A PAK4 RANBP9 HRAS RANBP10 MUC20 NCK1 MAP2K1 GAB1 MAP2K2 PTPN11 GAB2 PTK2 RAF1 PTPRJ PAK2 PTPN1 GRB2 HGS SOS1 CRK PTPN2 PARD6A CTNNB1 HGF SH3GL2 CDH1 CTNNA1 PIK3R1 APC EGF RECEPTOR (ERBB1) SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGF RECEPTOR (ERBB1) SIGNALING PATHWAY EGF receptor (ErbB1) signaling pathway TLN1 PLCG1 STAT1 STAT3 SHC1 SRC PIK3CA PTPN6 NCK2 NRAS HRAS NCK1 PIK3CB GAB1 PTPN11 PTK2 KRAS PTPN1 RASA1 GNAI3 GRB2 GNAI1 SOS1 EGFR PAK1 MAPK1 MAPK3 GSN EGF PIP5K1C PIK3R1 WASL PAR1-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR1-MEDIATED THROMBIN SIGNALING EVENTS PAR1-mediated thrombin signaling events MYL2 PKN1 F2RL2 ROCK1 GNA13 GNA14 PRKCD GNA15 PIK3CA GNAQ GNA11 F2 DNM1 PLCB2 ARRB1 AKAP13 PRKCB GRK3 SNX1 ARHGDIA GNG2 SNX2 VASP PRKCA PRKCG TRPC6 F2R ROCK2 PLCB3 GNB1 ZYX ARHGEF1 PLCB1 GNAI3 GNAI1 NOS3 RHOA GNAO1 GNAZ PIK3R1 GNA12 GNAI2 DNM2 SYNDECAN-4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SYNDECAN-4-MEDIATED SIGNALING EVENTS Syndecan-4-mediated signaling events FGFR1 TNFRSF13B ITGB1 LAMA1 LAMA3 PRKCD CXCR4 FN1 FGF2 F2 THBS1 PLG MDK ACTN1 PRKCA ITGA5 PTK2 SDC4 TFPI NUDT16L1 CXCL12 RAC1 SDCBP CCL5 GIPC1 FZD7 MMP9 RHOA TNC DNM2 ADAM12 P53 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P53 PATHWAY p53 pathway HIPK2 RPL11 PRKCD YY1 HUWE1 MAPK9 KAT5 MDM2 CCNA2 RCHY1 MAPK8 PPP2CA ABL1 AKT1 EP300 CHEK1 PRMT5 KAT2B MAPK14 TRIM28 NEDD8 SKP2 CSNK1G3 USP7 CSNK1D CSNK1E CREBBP CSNK1G2 CSNK1G1 RPL5 DYRK2 CSE1L CSNK1A1 SETD7 UBE2D1 TP53AIP1 RASSF1 PPP1R13L CHEK2 CDK2 KAT8 KMT5A DAXX RPL23 FBXO11 ATM TP53 PPM1D PTPA ATR COP1 SMYD2 E4F1 CDKN2A TTC5 CCNG1 PIN1 GSK3B MDM4 CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CALCINEURIN-REGULATED NFAT-DEPENDENT TRANSCRIPTION IN LYMPHOCYTES Calcineurin-regulated NFAT-dependent transcription in lymphocytes DGKA SLC3A2 PTPRK IKZF1 BCE1 CTLA4 GBP3 CXCL8 EGR2 EGR3 FOXP3 RNF128 CSF2 EGR1 PPARG CREM PRKCQ FASLG PTGS2 EGR4 CBLB JUNB JUN BATF3 GATA3 POU2F1 NFATC3 NFATC2 TBX21 NFATC1 FOS IL2 IL4 FOSL1 CASP3 IL3 CD40LG IFNG IL2RA PTPN1 MAF CALM3 IL5 CDK4 ITCH IRF4 E2F1 TNF E-CADHERIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING EVENTS E-cadherin signaling events JUP CDH1 CTNNB1 S1P2 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P2 PATHWAY S1P2 pathway CDH5 GNAI3 MAPK8 GNAI1 PAK1 MAPK14 MAPK1 RAC1 GNA13 MAPK3 GNA14 IRS1 GNA15 GNAQ ELK1 GNA11 JUN RHOA S1PR2 FOS GNAO1 GNAZ GNA12 GNAI2 NONGENOTROPIC ANDROGEN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONGENOTROPIC ANDROGEN SIGNALING Nongenotropic Androgen signaling AR CREB1 PLCG1 PELP1 GNRH1 SHBG SRC PIK3CA HRAS PLCB2 MAP2K1 FOS MAP2K2 GNG2 PTK2 PLCB3 GNB1 RAF1 CDC42 PLCB1 GNAI3 GNAI1 MAPK1 RAC1 MAPK3 AKT1 PLCG2 GNAO1 GNAZ PIK3R1 GNAI2 PLK3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLK3 SIGNALING EVENTS PLK3 signaling events CHEK2 CCNE1 TP53 CDC25C PLK3 VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF AP1 FAMILY MEMBERS FRA1 AND FRA2 Validated transcriptional targets of AP1 family members Fra1 and Fra2 CCL2 CCND1 DMTF1 CXCL8 ITGB4 LAMA3 FOSL2 TXLNG THBD HMOX1 LIF IL6 BGLAP USF2 JUNB DCN JUN MGP IVL ATF4 NFATC3 NFATC2 NFATC1 FOSL1 CCNA2 PLAU JUND NOS3 COL1A2 SP1 MMP1 MMP2 EP300 MMP9 CDKN2A PLAUR GJA1 ATM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATM PATHWAY ATM pathway YWHAB DCLRE1C XRCC4 TOP3A RAD17 CTBP1 RBBP8 RAD9A MDC1 ABRAXAS1 RNF8 TRIM28 SMC3 KAT5 UIMC1 TP53BP1 SMC1A MDM2 TERF2 UBE2N MRE11 BID BRCA1 NBN ABL1 CHEK2 RAD50 FANCD2 ATM H2AX BLM CDC25C COP1 CDC25A HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIV-1 NEF: NEGATIVE EFFECTOR OF FAS AND TNF-ALPHA HIV-1 Nef: Negative effector of Fas and TNF-alpha CYCS FASLG NFKB1 CASP9 CASP6 CASP8 CASP3 CASP7 RIPK1 MAP3K5 CD247 nef FADD TRAF1 MAP2K7 BID CASP2 MAPK8 CFLAR APAF1 FAS BIRC3 BAG4 CHUK DAXX MAP3K14 CRADD TRAF2 TNFRSF1A TNF RELA BCL2 ENDOGENOUS TLR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOGENOUS TLR SIGNALING Endogenous TLR signaling HSPD1 CD14 IKBKB IKBKG LY96 IRAK1 IRAK2 BGN IRAK4 TICAM1 TIRAP TLR1 VCAN SAA2 SFTPA1 TLR6 S100A9 TLR4 S100A8 TLR3 CHUK MYD88 TLR2 RHOA HMGB1 IL27-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL27-MEDIATED SIGNALING EVENTS IL27-mediated signaling events STAT4 IL12B JAK2 IL12RB1 STAT5A STAT1 STAT3 IL18 TYK2 IL6 IL1B GATA3 IL17A TBX21 IL2 IFNG IL6ST JAK1 EBI3 IL27 IL27RA IL12A IL12RB2 STAT2 TNF TGFB1 P75(NTR)-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P75(NTR)-MEDIATED SIGNALING p75(NTR)-mediated signaling BAD PRKCZ PIK3CA PLG MAPK9 CASP9 IKBKB CASP3 PRKCI IKBKG TRAF6 SQSTM1 IRAK1 MAPK8 MAPK10 MAGED1 NGFR RAC1 BIRC2 CHUK MYD88 AKT1 PSENEN RHOA FURIN PSEN1 APH1A PRDM4 SMPD2 NCSTN RIPK2 APH1B NSMCE3 MMP3 OMG RHOC RHOB CYCS MAG RTN4R MAGEH1 BEX3 ZNF274 BEX1 ADAM17 RTN4 NDN LINGO1 SORT1 SHC1 APP CASP6 PRKACB ARHGDIA NGF APAF1 NTF4 NTF3 BCL2L11 NTRK1 DIABLO BIRC3 XIAP BDNF MMP7 TP53 PIK3R1 E2F1 YWHAE CANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL WNT SIGNALING PATHWAY Canonical Wnt signaling pathway CUL3 AXIN1 LRP6 CSNK1G1 RANBP3 FZD5 PPP2R5A KLHL12 NKD2 DVL1 WNT3A DVL2 CTNNB1 DVL3 PIP5K1B PI4K2A GSK3A APC GSK3B CAV1 FGF SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FGF SIGNALING PATHWAY FGF signaling pathway CBL CAMK2A FGFR1 FGFR4 STAT5B PLCG1 STAT1 FGFR3 PDPK1 SHC1 SRC BGLAP PIK3CA KLB FGF1 JUN RPS6KA1 PAK4 NCAM1 IL17RD SSH1 FGFR2 GAB1 FOS PTPN11 FRS2 CDH2 SDC2 GRB2 PLAU SOS1 SPP1 MAPK1 SPRY2 CTTN MAPK3 FGF23 CTNND1 AKT1 MMP9 CDH1 PIK3R1 FGF19 PLAUR RUNX2 COREGULATION OF ANDROGEN RECEPTOR ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%COREGULATION OF ANDROGEN RECEPTOR ACTIVITY Coregulation of Androgen receptor activity CDK6 CCND1 KDM1A PELP1 UBE2I CASP8 TMPRSS2 PIAS1 KLK3 KLK2 VAV3 CARM1 GSN AKT1 MED1 PIAS4 TGIF1 NCOA2 PIAS3 PAWR AR RANBP9 HIP1 TGFB1I1 FHL2 UBE3A RPS6KA3 CCND3 ZMIZ1 NKX3-1 NRIP1 APPL1 PRKDC NCOA6 BRCA1 NCOA4 LATS2 CTDSP1 CTDSP2 MAK ZNF318 SNURF XRCC6 FKBP4 KDM3A XRCC5 TMF1 SRF PRDX1 PATZ1 UBA3 HNRNPA1 CTNNB1 SVIL KDM4C PA2G4 CDK11B TCF4 CMTM2 CDKN2A ALK2 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK2 SIGNALING EVENTS ALK2 signaling events SMAD9 SMAD5 SMAD4 AMHR2 AMH BMP7 BMPR2 TLX2 ACVR1 SMAD1 FKBP1A E-CADHERIN SIGNALING IN KERATINOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E-CADHERIN SIGNALING IN KERATINOCYTES E-cadherin signaling in keratinocytes FYN ZYX JUP EGFR PLCG1 PIP5K1A RAC1 CTNNB1 CTNND1 SRC PIK3CA AKT1 RHOA CDH1 CTNNA1 CASR AKT2 FMN1 PIK3R1 AJUBA VASP IL6-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL6-MEDIATED SIGNALING EVENTS IL6-mediated signaling events A2M TIMP1 MCL1 FGG PTPRE JAK2 VAV1 STAT1 MITF MAPK14 STAT3 TYK2 CEBPB PRKCD IL6 PIK3CA JUNB BCL2L1 JUN HCK FOXO1 IL6R GAB1 FOS PTPN11 IRF1 LMO4 GAB2 PIAS1 IL6ST MAP2K6 GRB2 SOS1 MAPK11 RAC1 MYC JAK1 CEBPD AKT1 MAP2K4 PIAS3 PIK3R1 CRP HSP90B1 TNFSF11 SOCS3 LBP EPHRINA-EPHA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINA-EPHA PATHWAY EphrinA-EPHA pathway EPHA8 EPHA3 EFNA5 EPHA2 EPHA5 EPHA4 EPHA7 EPHA6 ATR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ATR SIGNALING PATHWAY ATR signaling pathway YWHAB RFC5 RFC3 RFC4 SMARCAL1 MCM7 CEP164 RFC2 TIPIN CDC6 RPA1 PPP2R2B RPA2 TIMELESS HUS1 MCM2 RAD17 YWHAZ RAD1 RAD9A MDM2 BRCA2 CCNA2 PPP2CA TOPBP1 NBN PPP2R1A CLSPN BTRC CDK2 RAD51 FANCD2 FBXW11 PLK1 CDC25C ATR CDC25A CHEK1 ATRIP DEGRADATION OF BETA CATENIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DEGRADATION OF BETA CATENIN Degradation of beta catenin AXIN1 CSNK1D CSNK1E LRP6 FZD5 CSNK1A1 CUL1 BTRC SKP1 DVL1 WNT3A DVL2 CTNNB1 DVL3 AXIN2 GSK3A APC GSK3B IGF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IGF1 PATHWAY IGF1 pathway PDPK1 RACK1 BAD PRKCZ PRKCD RPS6KB1 PRKD1 IRS1 SHC1 YWHAZ PIK3CA PXN NCK2 IRS2 IGF1R GRB10 HRAS PTPN11 PTK2 RAF1 PTPN1 GRB2 SOS1 CRK CRKL AKT1 IGF1 BCAR1 PIK3R1 YWHAE VISUAL SIGNAL TRANSDUCTION: RODS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VISUAL SIGNAL TRANSDUCTION: RODS Visual signal transduction: Rods GUCY2D GUCA1B GNB1 GUCA1A GUCA1C GUCY2F RPE65 GRK1 RDH12 RGS9BP SLC24A1 PDE6G GNGT1 RDH5 RHO LRAT SAG CNGA1 GNB5 PDE6B RGS9 GNAT1 PDE6A CNGB1 CELLULAR ROLES OF ANTHRAX TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CELLULAR ROLES OF ANTHRAX TOXIN Cellular roles of Anthrax toxin MAP2K7 CASP1 MAP2K6 CALM3 MAPK1 IL18 MAPK3 IL1B MAP2K4 PGR MAP2K3 MAP2K1 cya MAP2K2 lef VCAM1 ANTXR2 ANTXR1 TNF NLRP1 DEFA1B pagA IL8- AND CXCR1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR1-MEDIATED SIGNALING EVENTS IL8- and CXCR1-mediated signaling events CBL CXCL8 PLD1 PDPK1 GNA14 PIK3R6 LYN PIK3CG GNA15 RAB5A FGR DNM1 HCK PLCB2 ARRB1 PRKCB PRKCE GNG2 PRKCA PRKCG CXCR1 PLCB3 GNB1 PLCB1 AKT1 GRK2 ARRB2 GNAI2 FOXM1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXM1 TRANSCRIPTION FACTOR NETWORK FOXM1 transcription factor network RB1 CCND1 CDK1 GSK3A NFATC3 MAP2K1 FOS ETV5 SKP2 BRCA2 CCNA2 LAMA4 ONECUT1 TGFA CCNB2 FOXM1 AURKB CENPB CREBBP CENPA CKS1B NEK2 H2BC1 CCNB1 XRCC1 ESR1 CENPF HSPA1B MYC CDK4 SP1 CHEK2 CDK2 MMP2 EP300 CCNE1 PLK1 BIRC5 CDC25B CDKN2A GAS1 BETA2 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA2 INTEGRIN CELL SURFACE INTERACTIONS Beta2 integrin cell surface interactions FGG ITGAM KNG1 ITGB2 ITGAL ITGAX ITGAD VCAM1 C3 CD40LG PLAU FCGR2A SPON2 ICAM2 ICAM3 ICAM4 F11R FGB FGA CCN1 F10 PLAT GP1BA PROC TGFBI ICAM1 JAM3 PLAUR THY1 PDGFR-BETA SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGFR-BETA SIGNALING PATHWAY PDGFR-beta signaling pathway YWHAB YWHAQ SFN PLCG1 YWHAG YWHAH PPP2R2B PRKCD YWHAZ BRAF ELK1 JUN NRAS MAPK9 FOS PRKCE KRAS JUND MYC VAV2 USP6NL SLA ACTN4 SLC9A3R2 SLC9A3R1 RAB4A DOCK4 MYOCD WASL ARAP1 ACTA2 CBL TAGLN FYN YES1 SIPA1 STAT5B PLA2G4A PIK3R6 PIK3CG RAB5A ARHGAP35 PDGFRB MAP2K1 MAP2K2 LCK RAF1 PDGFB PAG1 IQGAP1 LRP1 AFDN PIK3R1 PIN1 DNM2 EPS8 JAK2 STAT5A STAT1 STAT3 RAP1B SPHK1 PIK3CA NCK2 S1PR1 PIK3CB CYFIP2 NCKAP1 MAP2K7 ITGB3 WASF2 MAPK8 PPP2CA MAPK10 PAK1 ABL1 MAPK1 PPP2R1A ITGAV CTTN RAC1 ABI1 RAPGEF1 MAPK3 RHOA MAP2K4 KSR1 BCAR1 EIF2AK2 BLK LYN SHC1 SRC FGR RAP1A HCK GRB10 HRAS ARPC1B NCK1 BRK1 GAB1 PTPN11 ARHGDIA ACTR3 RPS6KA3 PRKCA ACTR2 DOK1 CSK PTPRJ RASA1 PTPN1 ARPC4 ARPC5 GRB2 SOS1 BAIAP2 CRK ARPC2 ARPC3 PTPN2 SRF PTEN YWHAE INSULIN-MEDIATED GLUCOSE TRANSPORT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN-MEDIATED GLUCOSE TRANSPORT Insulin-mediated glucose transport YWHAB ASIP YWHAQ PPP1R3A GYS1 SFN LNPEP TRIP10 YWHAG RHOQ YWHAH VAMP2 PRKCZ YWHAZ AKT2 STX4 STXBP4 PRKCI TBC1D4 INS INSR CALM3 PPP1CC SLC2A4 AKT1 YWHAE GSK3B ALK1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALK1 PATHWAY ALK1 pathway ACVRL1 ACVR1 FKBP1A NECTIN ADHESION PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NECTIN ADHESION PATHWAY Nectin adhesion pathway TLN1 PTPRM PVR CLDN1 RAP1B NECTIN3 NECTIN1 SRC PIK3CA RAP1A PDGFRB PTK2 NECTIN2 ITGB3 PDGFB CDC42 CRK ITGAV RAC1 RAPGEF1 CTNNB1 F11R PIP5K1C VAV2 IQGAP1 AFDN CDH1 CTNNA1 FARP2 PIK3R1 BCR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BCR SIGNALING PATHWAY BCR signaling pathway PDPK1 NFKB1 PIK3CA ELK1 JUN NFATC1 FOS IKBKB FCGR2B IKBKG TRAF6 CALM3 MAPK8 ETS1 BTK MAPK1 MAP4K1 RAC1 MAPK3 MAP3K1 SYK POU2F2 CHUK AKT1 VAV2 DAPP1 PLCG2 BLNK CAMK2G INPP5D MAPK14 PPP3CB LYN PPP3CC SHC1 CSNK2A1 CARD11 PTPN6 BCL2A1 BCL10 MALT1 CD79B PPP3CA HRAS CD79A CD19 SH3BP5 MAP2K1 CD72 IBTK PTPRC CD22 NFKBIB MAP3K7 DOK1 RAF1 CSK RASA1 GRB2 SOS1 PAG1 PTEN PIK3R1 RELA REGULATION OF RHOA ACTIVITY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RHOA ACTIVITY Regulation of RhoA activity CDKN1B ABR DEF6 VAV1 BCR ARHGEF2 ARHGAP35 AKAP13 ARHGAP5 ARHGDIA ARHGAP8 ARHGDIG ARHGEF10L ARHGAP6 ARHGDIB ARHGAP4 OPHN1 ARHGEF1 SRGAP1 ARHGEF10 FARP1 ARHGEF12 ARHGEF17 PLEKHG6 ARHGEF18 MYO9B NET1 VAV3 OBSCN ECT2 DLC1 ARHGEF3 ARHGEF15 ARHGEF5 ARHGEF25 VAV2 ARHGEF11 RHOA ARHGEF28 MCF2L NGEF ARAP3 MCF2 TRIO ARHGAP9 ARAP1 EFFECTS OF BOTULINUM TOXIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EFFECTS OF BOTULINUM TOXIN Effects of Botulinum toxin VAMP2 UNC13B CHRNA1 SNAP25 SYT1 STXBP1 botG botE botF RIMS1 botD botA botB RAB3GAP2 STX1A NOTCH SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NOTCH SIGNALING PATHWAY Notch signaling pathway ADAM10 NOTCH2 NOTCH3 MYCBP NOTCH1 MAML2 CCND1 NOTCH4 KDM1A DTX1 MAML1 DLL1 DLL3 DLL4 MARK2 RBPJ JAG2 JAG1 CUL1 CNTN6 SKP1 DLK1 RAB11A MIB1 YY1 MFAP5 NEURL1 MFAP2 CNTN1 RBBP8 LNX1 DNM1 SPEN NCOR2 IL4 CDKN1A FBXW7 BTRC MYC PSENEN ITCH EP300 FURIN APH1A NCSTN APH1B ADAM12 CBL NCOR1 NUMB CTBP1 HDAC1 EPS15 GATA3 SKP2 PTCRA ENO1 DNER GLYPICAN 2 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 2 NETWORK Glypican 2 network GPC2 MDK IL2 SIGNALING EVENTS MEDIATED BY STAT5%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2 SIGNALING EVENTS MEDIATED BY STAT5 IL2 signaling events mediated by STAT5 CDK6 ELF1 STAT5A STAT5B FOXP3 FASLG SHC1 PIK3CA BCL2L1 PRF1 PTPN11 IL2 IL4 GAB2 CCND3 CCNA2 LCK IL2RA GRB2 SOS1 JAK3 MYC JAK1 SP1 CCND2 IL2RB LTA PIK3R1 BCL2 IL2RG IL8- AND CXCR2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL8- AND CXCR2-MEDIATED SIGNALING EVENTS IL8- and CXCR2-mediated signaling events CBL CXCL8 ELMO1 PLD2 DOCK2 PDPK1 RAB11A GNA14 PIK3R6 LYN PIK3CG GNA15 RAB5A FGR DNM1 HCK CXCR2 RAC2 PLCB2 RAB7A ARRB1 PRKCB GNG2 VASP PRKCA PRKCG PLCB3 GNB1 PLCB1 PPP2CA PPP2R1A AKT1 ARRB2 GNAI2 ERBB2 ERBB3 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB2 ERBB3 SIGNALING EVENTS ErbB2 ErbB3 signaling events NRG2 JAK2 STAT3 MTOR BAD PPP3CB SHC1 SRC PRKACA PIK3CA JUN NRAS HRAS MAPK9 DOCK7 PIK3CB ERBB3 MAP2K1 FOS CHRNE MAP2K2 PTPN11 USP8 RNF41 NFATC4 NF2 KRAS RAF1 CDC42 MAPK8 GRB2 MAPK10 SOS1 MAPK1 RAC1 MAPK3 NRG1 CHRNA1 AKT1 PIK3R1 ERBB2 FOXA TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA TRANSCRIPTION FACTOR NETWORKS FOXA transcription factor networks FOXA3 FOXA2 FOXA1 PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PROTEOGLYCAN SYNDECAN-MEDIATED SIGNALING EVENTS Proteoglycan syndecan-mediated signaling events SDC2 SDC1 SDC3 SDC4 BETA3 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA3 INTEGRIN CELL SURFACE INTERACTIONS Beta3 integrin cell surface interactions COL4A6 COL4A5 FGG SDC1 TGFBR2 PVR ITGA2B SPHK1 FN1 THBS1 KDR PDGFRB LAMB1 LAMA4 ITGB3 IBSP EDIL3 PDGFB L1CAM SDC4 PECAM1 PLAU CD47 SPP1 FBN1 LAMC1 VTN ITGAV COL1A2 F11R FGB FGA CCN1 VEGFA COL1A1 TNC HMGB1 TGFBI COL4A1 PLAUR COL4A4 THY1 COL4A3 THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBIN PROTEASE-ACTIVATED RECEPTOR (PAR) PATHWAY Thrombin protease-activated receptor (PAR) pathway F2 IL2-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL2-MEDIATED SIGNALING EVENTS IL2-mediated signaling events STAT5A STAT1 STAT3 PIK3CA JUN NRAS MAPK9 PRKCB FOS PRKCE IL2 KRAS IFNG IL2RA MAPK8 MAPK11 IKZF3 CISH STAM2 MAPK1 SOCS2 STAM MAPK3 JAK3 MYC JAK1 SYK RHOA DOK2 IL2RG SOCS1 FYN STAT5B MAPK14 MAPKAPK2 IRS1 SHC1 IRS2 HRAS MAP2K1 MAP2K2 PTPN11 GAB2 LCK RAF1 RASA1 GRB2 SOS1 CDK2 IL2RB PIK3R1 BCL2 SOCS3 GLYPICAN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN PATHWAY Glypican pathway GPC3 GPC2 GPC1 CIRCADIAN RHYTHM PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CIRCADIAN RHYTHM PATHWAY Circadian rhythm pathway CSNK1E TIMELESS NONO NR1D1 NPAS2 ARNTL PER2 DELEC1 PER1 CRY2 BHLHE40 WDR5 CRY1 CLOCK ATR CHEK1 IL12-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL12-MEDIATED SIGNALING EVENTS IL12-mediated signaling events IL18RAP B2M STAT4 EOMES IL12B HLA-A JAK2 IL12RB1 STAT5A NOS2 STAT1 CD8B CD8A STAT3 IL18 FASLG TYK2 NFKB1 CD4 GZMB IL1B CD3G IL18R1 CD3D RAB7A TBX21 FOS IL2 IL4 HLA-DRA CD247 HLA-DRB1 IFNG IL2RA MAP2K6 ATF2 IL12A IL12RB2 CCR5 SPHK2 IL1R1 RELB RIPK2 HLX CCL4 CCL3 GADD45B IL2RG GZMA NFKB2 SOCS1 GADD45G STAT6 MAPK14 MTOR LCK IL2RB MAP2K3 CD3E RELA BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA5 BETA6 BETA7 AND BETA8 INTEGRIN CELL SURFACE INTERACTIONS Beta5 beta6 beta7 and beta8 integrin cell surface interactions SDC1 EDIL3 TGFBR1 PLAU FBN1 ITGB5 VTN ITGAV FN1 ITGB8 ITGB7 ITGB6 CCN1 ITGA4 VCAM1 PLAUR MADCAM1 INTEGRINS IN ANGIOGENESIS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTEGRINS IN ANGIOGENESIS Integrins in angiogenesis COL4A6 COL4A5 CDKN1B COL6A3 SDC1 TLN1 VCL ROCK1 FN1 PIK3CA FGF2 CASP8 ITGB3 ILK EDIL3 SPP1 MAPK1 ITGAV RAC1 MAPK3 VAV3 F11R AKT1 RHOA BCAR1 CBL PIK3C2A ADGRA2 ANGPTL3 MFGE8 PI4KA TGFBR2 PI4KB RPS6KB1 IRS1 SRC PXN IGF1R KDR CSF1 PTPN11 PTK2 COL11A1 VTN COL11A2 CSF1R COL1A2 IGF1 VEGFA COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL7A1 PIK3R1 COL6A2 HSP90AA1 COL4A4 COL5A2 COL6A1 COL4A3 SIGNALING EVENTS MEDIATED BY HDAC CLASS III%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS III Signaling events mediated by HDAC Class III KAT2B SIRT7 SIRT1 SIRT2 ACSS2 SIRT3 HOXA10 MYOD1 TUBA1B ACSS1 MEF2D H4C9 tat H1-4 TUBB2A FOXO4 FOXO3 HDAC4 FOXO1 FHL2 PPARGC1A CREBBP CDKN1A XRCC6 EP300 TP53 BAX RETINOIC ACID RECEPTORS-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RETINOIC ACID RECEPTORS-MEDIATED SIGNALING Retinoic acid receptors-mediated signaling KAT2B CDK1 MAPK14 HDAC3 NCOA3 CCNH PRKACA HDAC1 CDK7 RBP1 MNAT1 NCOR2 PRKCA PRKCG NRIP1 RXRB MAPK8 CREBBP RXRA RXRG VDR MAPK1 RARG MAPK3 AKT1 EP300 NCOA1 RARA NCOA2 RARB HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HYPOXIC AND OXYGEN HOMEOSTASIS REGULATION OF HIF-1-ALPHA Hypoxic and oxygen homeostasis regulation of HIF-1-alpha ELOB HIF1AN VHL ELOC EGLN1 HIF1A EGLN3 COPS5 RACK1 EGLN2 NAA10 CUL2 HIF3A TP53 RBX1 OS9 ARNT HSP90AA1 CDKN2A FOXA1 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA1 TRANSCRIPTION FACTOR NETWORK FOXA1 transcription factor network CDKN1B AR COL18A1 CEBPB DSCAM NCOA3 AP1B1 JUN POU2F1 TFF1 FOS SERPINA1 SFTPA2 PRDM15 C4BPB CYP2C18 SFTPD FOXA1 GCG KLK3 NRIP1 NKX3-1 NR2F2 FOXA3 INS PISD FOXA2 NFIA BRCA1 NDUFV3 NFIB ATP5PF NFIC XBP1 CREBBP SCGB1A1 VTN ESR1 SFTPA1 SOD1 SP1 EP300 SHH APOB PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PLASMA MEMBRANE ESTROGEN RECEPTOR SIGNALING Plasma membrane estrogen receptor signaling PELP1 GNA13 HBEGF GNA14 SHC1 GNA15 SRC PIK3CA GNAQ GNA11 NRAS IGF1R HRAS PLCB2 GNG2 KRAS ROCK2 PLCB3 GNB1 PLCB1 GNAI3 GRB2 GNAI1 GNAL SOS1 MAPK11 STRN ESR1 ESR2 NOS3 AKT1 MMP2 IGF1 MMP9 RHOA BCAR1 GNAO1 GNAZ PIK3R1 MSN GNAI2 NONCANONICAL WNT SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NONCANONICAL WNT SIGNALING PATHWAY Noncanonical Wnt signaling pathway CAMK2A YES1 TAB2 TAB1 ROCK1 PPARG PRKCZ DVL1 DVL2 DVL3 MAPK9 NFATC2 MAP3K7 CDC42 MAPK8 MAPK10 CHD7 CTHRC1 FLNA FZD2 SETDB1 RAC1 FZD5 CSNK1A1 DAAM1 FZD7 WNT5A NLK FZD6 RHOA ARRB2 ROR2 REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF NUCLEAR BETA CATENIN SIGNALING AND TARGET GENE TRANSCRIPTION Regulation of nuclear beta catenin signaling and target gene transcription YWHAB CACNA1G IGF2BP1 TBL1X YWHAQ CDX4 CCND1 CDX1 KCNIP4 SFN KLF4 CXCL8 SMARCA4 YWHAG BCL9 YWHAH TCF7L2 SP5 NEUROG1 MYF5 CUL1 SKP1 YWHAZ CAMK4 JUN TLE1 ID2 XPO1 RUVBL2 TBXT INCENP TCF7L1 VCAN BTRC MYC SNAI2 MMP2 EP300 MMP9 NCOA2 AR MITF HDAC2 HBP1 DVL3 CTBP1 AXIN2 HDAC1 ZCCHC12 CHD8 TRRAP CBY1 FGF4 CTNNB1 MED12 CCND2 SALL4 PITX2 LEF1 CCN1 MYOG TLE4 TCF4 CDH1 TLE2 CTNNBIP1 KRT1 TLE5 DKK4 TERT DKK1 MDFIC TBL1XR1 MT-CO2 CDKN2A TNIK YWHAE TCF7 APC ADCY7 EPO SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPO SIGNALING PATHWAY EPO signaling pathway CBL INPP5D EPO JAK2 STAT5A STAT5B PLCG1 STAT1 MAPK14 NFKB1 LYN SHC1 PTPN6 BCL2L1 IRS2 RAP1A HRAS GAB1 PTPN11 MAPK8 GRB2 SOS1 BTK CRKL SH2B3 RAPGEF1 EPOR TEC VAV2 PLCG2 PIK3R1 BCL2 SOCS3 P38 MAPK SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 MAPK SIGNALING PATHWAY p38 MAPK signaling pathway GADD45G TAB2 TAB1 CAMK2B MAPK14 MAP3K6 MAP3K4 TAOK3 TAOK1 TAOK2 MAP3K10 MAP3K5 MAP3K7 TXN MAP3K3 TRAF6 MAP2K6 CCM2 CALM3 MAPK11 GADD45A RAC1 MAP3K1 MAP2K3 ATM TRAF2 GADD45B C-MYC PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%C-MYC PATHWAY C-MYC pathway AXIN1 TAF9 KAT2A TAF12 HBP1 MAX TAF10 RUVBL1 PML KAT5 RUVBL2 SKP2 ZBTB17 PAK2 PPP2CA FBXW7 PPP2R5A TRRAP MYC ACTL6A SUPT7L CDKN2A SUPT3H PIN1 GSK3B S1P1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%S1P1 PATHWAY S1P1 pathway PDGFB GNAI3 GNAI1 PLCG1 MAPK1 ABCC1 RAC1 SPHK1 MAPK3 PTGS2 VEGFA S1PR1 RHOA KDR PLCB2 PDGFRB GNAO1 GNAZ GNAI2 GLYPICAN 1 NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLYPICAN 1 NETWORK Glypican 1 network FYN FLT1 YES1 FGFR1 BLK TGFBR1 TGFBR2 LAMA1 LYN SRC FGF2 SERPINC1 FGR SLIT2 HCK PRNP PLA2G2A TDGF1 APP LCK SMAD2 GPC1 NRG1 VEGFA TGFB1 TGFB3 VEGF AND VEGFR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGF AND VEGFR SIGNALING NETWORK VEGF and VEGFR signaling network FLT1 VEGFA KDR NRP1 NRP2 FLT4 VEGFC VEGFB VEGFD PGF ENDOTHELINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ENDOTHELINS Endothelins SLC9A3 EDN1 JAK2 PRKCQ PRKCD GNA14 GNA15 GNAQ GNA11 JUN PRKCB FOS PRKCE EDNRA CYSLTR1 EDNRB CYSLTR2 PRKCH EDN2 EDN3 ADCY9 CDC42 ADCY4 MAPK8 ADCY3 ADCY2 ADCY1 ADCY8 MAPK1 ADCY6 RAC1 ADCY5 MAPK3 AKT1 RHOA BCAR1 PLA2G4A MAPK14 SRC HRAS PLCB2 MAP2K1 MAP2K2 PRKCA PRKCG TRPC6 PLCB3 RAF1 PLCB1 GNAI3 GNAI1 GNAL CRK SLC9A1 COL1A2 MMP1 COL3A1 GNAO1 GNAZ GNA12 GNAI2 ADCY7 NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%NEPHRIN NEPH1 SIGNALING IN THE KIDNEY PODOCYTE Nephrin Neph1 signaling in the kidney podocyte FYN F2RL2 PLCG1 BAD PRKCZ PIK3CA NCK2 JUN MAPK9 NCK1 PIK3CB PRKCI TRPC6 MAPK8 GRB2 MAPK10 TJP1 RAC1 KIRREL1 CD2AP NPHS1 PARD6A NPHS2 AKT1 MAP2K4 PIK3R1 ARRB2 WASL LPA RECEPTOR MEDIATED EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA RECEPTOR MEDIATED EVENTS LPA receptor mediated events CXCL8 PLCG1 PRKCD PRKD1 GNA14 NFKB1 TRIP6 GNA15 GNAQ GNA11 JUN PIK3CB FOS PRKCE CASP3 ADCY9 ADCY4 ADCY3 ADCY2 TIAM1 ADCY1 ADCY8 ADCY6 RAC1 ADCY5 ADRA1B LPAR1 AKT1 MMP2 LPAR2 MMP9 LPAR3 RHOA LPAR4 BCAR1 SLC9A3R2 PLD2 HBEGF GNA13 LYN SRC PXN MAPT HRAS GAB1 GNG2 PTK2 PLCB3 GNB1 ARHGEF1 GNAI3 GNAI1 CRK EGFR GNAO1 GNAZ PIK3R1 GNA12 GNAI2 RELA GSK3B ADCY7 UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%UROKINASE-TYPE PLASMINOGEN ACTIVATOR (UPA) AND UPAR-MEDIATED SIGNALING Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling FGG ITGB1 ITGA3 ITGAM DOCK1 ITGB2 FN1 SRC PLG PDGFRB ITGA5 ITGB3 PLAU EGFR CRK ITGB5 SERPINE1 VTN ITGAV RAC1 FGB FGA HGF LRP1 MMP9 FPR1 KLK4 BCAR1 FPR3 ELANE NCL FPR2 VLDLR PDGFD CTSG PLAUR MMP12 TGFB1 MMP3 MMP13 CTRC GPLD1 VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TARGETS OF C-MYC TRANSCRIPTIONAL REPRESSION Validated targets of C-MYC transcriptional repression CDKN1B CCND1 LGALS1 ID2 DDIT3 CFLAR CDKN1A SPI1 GADD45A MYC EP300 ERBB2 GFI1 CLU FTH1 HMGCS2 TBP SLC11A1 RBL1 DNMT3A DNTT CREB1 TSC2 SFRP1 ITGB1 TMEFF2 CSDE1 ITGB4 TMEM126A S100A7 ALDH9A1 HDAC3 NDRG2 NDRG1 IRF8 MAX ZFP36L1 NFYA HDAC1 NFYB NFYC GTF2H2 SFXN3 FOXO3 TJP2 MXD4 PDGFRB ITGA6 SMAD2 ZBTB17 BRCA1 SMAD4 CDKN2B SMAD3 CCL5 COL1A2 CEBPA SP1 CEBPD WNT5A PTPA DKK1 BCL2 BETA1 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BETA1 INTEGRIN CELL SURFACE INTERACTIONS Beta1 integrin cell surface interactions COL4A6 COL4A5 FGG COL6A3 ITGA3 LAMA1 LAMA3 FN1 LAMA4 PLAU SPP1 FBN1 LAMC1 ITGAV FGB FGA TNC F13A1 TGFBI TGM2 COL18A1 ITGB1 IGSF8 CD81 ITGA4 LAMA2 THBS2 ITGA2 THBS1 LAMB3 ITGA1 LAMB2 LAMC2 MDK NPNT CD14 LAMB1 ITGA10 NID1 ITGA11 ITGA8 JAM2 CSPG4 ITGA7 VCAM1 ITGA6 ITGA5 ITGA9 LAMA5 COL11A1 VTN COL11A2 COL1A2 VEGFA COL1A1 COL3A1 COL2A1 COL5A1 COL4A1 COL7A1 COL6A2 PLAUR COL4A4 COL5A2 COL6A1 COL4A3 ERBB RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB RECEPTOR SIGNALING NETWORK ErbB receptor signaling network NRG2 TGFA EREG BTC EGFR NRG3 NRG4 HBEGF NRG1 EGF ERBB3 AREG HSP90AA1 ERBB4 ERBB2 SIGNALING EVENTS MEDIATED BY HDAC CLASS II%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY HDAC CLASS II Signaling events mediated by HDAC Class II YWHAB TUBA1B HDAC5 HDAC3 GATA1 GATA2 BCL6 HDAC9 TUBB2A CAMK4 HDAC6 HDAC7 HDAC4 RANBP2 UBE2I XPO1 SUMO1 NCOR2 GNG2 RFXANK RANGAP1 BCOR ANKRA2 RAN GNB1 ESR1 NR3C1 SRF GRK2 MEF2C HDAC10 HDAC11 HSP90AA1 YWHAE TGF-BETA RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TGF-BETA RECEPTOR SIGNALING TGF-beta receptor signaling CAMK2A TAB2 TAB1 PDPK1 PML YAP1 FKBP1A PPP2CA NEDD4L WWP1 ITCH EIF2A ARRB2 TGFB1 TGFB3 CAV1 AXIN1 TGFBR1 TGFBR2 PPP1CA RPS6KB1 SHC1 SMURF1 ZFYVE9 MAP3K7 PPP2R2A DACT2 SMAD2 RNF111 TGFBR3 ZFYVE16 SMAD4 STRAP GRB2 SOS1 PPP1R15A TGFBRAP1 SMAD3 PPP2CB SPTBN1 SMURF2 SMAD7 DAB2 OCLN XIAP BAMBI DYNLRB1 PARD6A CTNNB1 DAXX CCN2 YWHAE ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALPHAE BETA7 INTEGRIN CELL SURFACE INTERACTIONS AlphaE beta7 integrin cell surface interactions ITGB7 CDH1 ITGAE JNK SIGNALING IN THE CD4+ TCR PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%JNK SIGNALING IN THE CD4+ TCR PATHWAY JNK signaling in the CD4+ TCR pathway MAPK8 CRK GRAP2 MAP4K1 CRKL LAT MAP3K1 DBNL JUN MAP3K8 MAP2K4 LCP2 PRKCB MAP3K7 TCR SIGNALING IN NAIVE CD4+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD4+ T CELLS TCR signaling in naive CD4+ T cells VAV1 PLCG1 PRKCQ PDPK1 RASGRP2 RASGRP1 CD4 ITK CD86 CD80 MAP3K8 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 HLA-DRA CD247 KRAS HLA-DRB1 IKBKG TRAF6 CDC42 GRAP2 MAP4K1 CHUK AKT1 MAP3K14 ZAP70 CBL FYN INPP5D SHC1 CARD11 PTPN6 BCL10 MALT1 RAP1A HRAS NCK1 PTPN11 PTPRC PRKCA GAB2 LCK CSK GRB2 SOS1 TRPV6 FLNA PAG1 LAT PTEN DBNL SLA2 RASSF5 STIM1 ORAI1 WAS STK39 SH3BP2 FYB1 CD3E ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ROLE OF CALCINEURIN-DEPENDENT NFAT SIGNALING IN LYMPHOCYTES Role of Calcineurin-dependent NFAT signaling in lymphocytes YWHAB YWHAQ SFN YWHAG YWHAH PRKCQ AKAP5 BAD PRKCD PRKCZ CABIN1 CHP1 YWHAZ PRKACA CAMK4 MAP3K8 NFATC3 MAPK9 NFATC2 NFATC1 PRKCB XPO1 PRKCE CASP3 FKBP1A RCAN1 RAN PRKCH RCAN2 CALM3 MAPK8 MAPK3 MAP3K1 EP300 NR4A1 BAX MAPK14 MEF2D CSNK2A1 KPNB1 BCL2L1 PIM1 PRKCA PRKCG CREBBP CSNK1A1 KPNA2 NUP214 FKBP8 YWHAE BCL2 GSK3B VEGFR1 SPECIFIC SIGNALS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR1 SPECIFIC SIGNALS VEGFR1 specific signals CBL FLT1 PLCG1 HIF1A PDPK1 PRKACA PIK3CA NRP1 NCK1 NRP2 PRKCB PTPN11 VEGFB PGF PRKCA RASA1 SHC2 CALM3 MAPK1 MAPK3 CD2AP NOS3 AKT1 VEGFA PIK3R1 HSP90AA1 CAV1 EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EGFR-DEPENDENT ENDOTHELIN SIGNALING EVENTS EGFR-dependent Endothelin signaling events EGF SHC1 EDN1 GRB2 SOS1 HRAS EGFR MTOR EDNRA HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HEDGEHOG SIGNALING EVENTS MEDIATED BY GLI PROTEINS Hedgehog signaling events mediated by Gli proteins RAB23 SAP30 SUFU SPOP MTSS1 IFT88 HDAC2 PRKCD PRKACA HDAC1 LGALS3 RBBP4 MAP2K1 XPO1 SAP18 RBBP7 GNG2 CSNK1G3 PIAS1 CSNK1D FOXA2 CSNK1E GNB1 GNAI3 CREBBP GNAI1 CSNK1G2 CSNK1G1 CSNK1A1 SIN3B BTRC SIN3A PTCH1 AKT1 FBXW11 GLI2 SHH GNAO1 GNAZ ARRB2 SMO IFT172 GLI1 GLI3 GNAI2 KIF3A GSK3B STK36 PDGF RECEPTOR SIGNALING NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PDGF RECEPTOR SIGNALING NETWORK PDGF receptor signaling network PDGFB PDGFC PDGFRB PDGFD PDGFRA PDGFA INSULIN PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INSULIN PATHWAY Insulin Pathway CBL INPP5D EXOC4 EXOC3 EIF4EBP1 EXOC6 SORBS1 EXOC5 F2RL2 TRIP10 EXOC2 RHOQ EXOC1 PDPK1 PRKCZ RPS6KB1 IRS1 SHC1 PIK3CA NCK2 GRB14 GRB10 FOXO3 HRAS NCK1 AKT2 PTPN11 PRKCI DOK1 PTPRA INS PTPN1 RASA1 INSR GRB2 SGK1 SOS1 CRK RAPGEF1 SH2B2 PARD6A AKT1 EXOC7 PIK3R1 CAV1 ERBB1 DOWNSTREAM SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ERBB1 DOWNSTREAM SIGNALING ErbB1 downstream signaling YWHAB YWHAQ SFN F2RL2 YWHAG YWHAH EGR1 PDPK1 BAD PRKCD PRKCZ YWHAZ BRAF ELK1 JUN NRAS MAPK9 FOS DUSP1 KRAS RIN1 PEBP1 CALM3 ATF2 AKT1 VAV2 USP6NL MEF2C ATF1 WASL RPS6KA4 RPS6KA5 CREB1 MTOR RAB5A BCL2L1 MAP2K1 MAP2K2 PPP2R2A RAF1 EGFR RALA EGF IQGAP1 PIK3R1 RPS6 EPS8 CHN2 ZFP36 RALGDS STAT1 MAP2K5 MYLPF STAT3 PPP5C DIAPH3 ARF4 DUSP6 MAPK7 MAP3K2 PIK3CA MAPKAP1 PIK3CB MLST8 RICTOR CYFIP2 NCKAP1 WASF2 CDC42 MAPK8 PPP2CA MAPK1 PPP2R1A RAC1 ABI1 MAPK3 MAP3K1 MAP2K4 KSR1 SMAD1 PLD1 PLD2 SRC HRAS ARPC1B BRK1 GAB1 ACTR3 RPS6KA3 PRKCA ACTR2 ARPC4 ARPC5 GRB2 SOS1 BAIAP2 SH2D2A ARPC2 ARPC3 SRF SLC9A1 CAPN2 YWHAE LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LISSENCEPHALY GENE (LIS1) IN NEURONAL MIGRATION AND DEVELOPMENT Lissencephaly gene (LIS1) in neuronal migration and development MAP1B PLA2G7 CSNK2A1 LRP8 RELN KATNA1 NDEL1 DYNC1H1 CLIP1 DAB1 DCX PAFAH1B3 CDK5R2 PAFAH1B2 CDK5R1 PAFAH1B1 DYNLT1 CDC42 CALM3 ABL1 RAC1 LRPAP1 NUDC IQGAP1 PPP2R5D RHOA CDK5 VLDLR YWHAE SIGNALING EVENTS MEDIATED BY PRL%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY PRL Signaling events mediated by PRL RABGGTA CCNA2 PTP4A1 PTP4A2 PTP4A3 ATF5 CDKN1A ROCK1 ITGB1 MAPK1 EGR1 AGT TUBA1B RAC1 MAPK3 SRC CDK2 RHOA CCNE1 ITGA1 BCAR1 RHOC RABGGTB EPHA2 FORWARD SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHA2 FORWARD SIGNALING EPHA2 forward signaling CBL GRB2 ACP1 TIAM1 PAK1 RAC1 VAV3 SHC1 SRC INPPL1 PIK3CA VAV2 EFNA1 RHOA ARHGAP35 BCAR1 PIK3R1 EPHA2 PTK2 VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VEGFR3 SIGNALING IN LYMPHATIC ENDOTHELIUM VEGFR3 signaling in lymphatic endothelium CREB1 ITGB1 MAPK14 SHC1 FN1 PIK3CA RPS6KA1 ITGA4 ITGA2 ITGA1 FLT4 ITGA5 GRB2 SOS1 MAPK11 CRK MAPK1 MAPK3 COL1A2 AKT1 COL1A1 MAP2K4 PIK3R1 VEGFC VEGFD EPHRIN B REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN B REVERSE SIGNALING Ephrin B reverse signaling FYN YES1 BLK EFNB2 ITGA2B EFNB1 EPHB2 LYN EPHB1 SRC EPHB4 PIK3CA NCK2 FGR DNM1 HCK PTPN13 MAP3K7 LCK ITGB3 MAPK8 RGS3 TIAM1 RAC1 MAP2K4 PIK3R1 ARF6 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF6 SIGNALING EVENTS Arf6 signaling events AGTR1 MET ARF6 ITGA2B GNA14 GNA15 SRC GNAQ PXN GNA11 ARRB1 NCK1 ITGB3 EGFR KIF13B FBXO8 LHCGR USP6 IQSEC1 ARAP2 IPCEF1 GULP1 ACAP2 EGF ADRB2 HGF CYTH3 EFNA1 CYTH2 GIT1 ARRB2 EPHA2 ADAP1 TSHR ACAP1 P73 TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P73 TRANSCRIPTION FACTOR NETWORK p73 transcription factor network RB1 BIN1 CDK6 SFN ADA JAG2 RACK1 GATA1 HEY2 PML KAT5 PLPP1 YAP1 MDM2 BRCA2 CCNA2 RCHY1 CDKN1A MAPK11 NEDD4L SERPINE1 CCNB1 ABL1 FAS MYC JAK1 BUB1 IL1RAP BBC3 IL4R TUBA1A ITCH PEA15 EP300 FLOT2 FASN RNF43 S100A2 UBE4B PLK1 AEN CCNE2 NDUFS2 HAGH CHEK1 PFDN5 FBXO45 AFP PLK3 GRAMD4 BAX HSF1 CLCA2 WWOX BUB3 BAK1 DEDD CDK1 TP63 GDF15 SIRT1 NSG1 TP53I3 WT1 MAPK14 TP73 DCP1B FOXO3 PRKACB SERPINA1 CASP2 BCL2L11 NTRK1 TP53AIP1 SP1 CDK2 RAD51 RELA PIN1 CXCR3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR3-MEDIATED SIGNALING EVENTS CXCR3-mediated signaling events MAPK14 CXCL13 MTOR CXCR3 PDPK1 CXCL10 CXCL11 PF4 SRC PIK3CA NRAS DNM1 HRAS MAPKAP1 ARRB1 PIK3CB MAP2K1 MAP2K2 MLST8 GNG2 RICTOR KRAS GNB1 RAF1 MAP2K6 GNAI3 GNAI1 MAPK11 MAPK1 MAPK3 AKT1 CXCL9 MAP2K3 GNAO1 GNAZ PIK3R1 CCL11 GNAI2 A6B1 AND A6B4 INTEGRIN SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%A6B1 AND A6B4 INTEGRIN SIGNALING a6b1 and a6b4 Integrin signaling YWHAB YWHAQ SFN MET YWHAG ITGB1 YWHAH LAMA1 ITGB4 LAMA3 RPS6KB1 COL17A1 SHC1 YWHAZ PIK3CA PMP22 CD9 LAMA2 LAMB3 HRAS LAMB2 LAMC2 LAMB1 ERBB3 ITGA6 PRKCA CASP7 MST1 LAMA4 RXRB GRB2 RXRA EGFR RXRG LAMA5 LAMC1 RAC1 EGF IL1A AKT1 CDH1 MST1R PIK3R1 YWHAE ERBB2 THROMBOXANE A2 RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%THROMBOXANE A2 RECEPTOR SIGNALING Thromboxane A2 receptor signaling ROCK1 PRKCQ RAB11A PRKCD PRKCZ GNA14 GNA15 PRKACA GNAQ GNA11 DNM1 PRKCB PRKCE PRKG1 PRKCH MAPK11 SELE RAC1 SYK AKT1 RHOA TGM2 GRK2 ARRB2 SLC9A3R1 FYN YES1 ARR3 BLK MAPK14 GNA13 PIK3R6 LYN PIK3CG SRC PTGDR FGR PTGIR HCK GNB5 TBXA2R PLCB2 GRK3 VCAM1 GNG2 PRKCA PRKCG LCK GNB1 ARHGEF1 EGFR NOS3 EGF ICAM1 GNA12 GNAI2 IL3-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL3-MEDIATED SIGNALING EVENTS IL3-mediated signaling events INPP5D JAK2 STAT5A STAT5B YWHAG ID1 CEBPB PRKACG OSM SHC1 YWHAZ PRKACA PIK3CA HDAC1 BCL2L1 SRP9 CNKSR1 IL3RA PRKACB PTPN11 PIM1 GAB2 IL3 GRB2 CISH CSF2RB PIK3R1 MTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%MTOR SIGNALING PATHWAY mTOR signaling pathway YWHAB YWHAQ SFN YWHAG YWHAH PDPK1 YY1 YWHAZ BRAF PML NRAS CLIP1 MAPKAP1 IKBKB MLST8 RICTOR KRAS PPARGC1A MAPK1 MAPK3 BTRC SREBF1 AKT1 FBXW11 CYCS EIF4EBP1 EIF4E TSC2 PLD1 PLD2 MTOR RPTOR DEPTOR AKT1S1 RPS6KB1 IRS1 EEF2K RPS6KA1 HRAS PRR5 MAP2K1 RB1CC1 MAP2K2 TSC1 ATG13 PRKCA RRAGA RRAGC RRAGB RRAGD DDIT4 ULK2 RAF1 ULK1 RRN3 SGK1 POLDIP3 EIF4B BNIP3 EEF2 RHEB PDCD4 EIF4A1 CDK2 CCNE1 YWHAE ALTERNATIVE NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ALTERNATIVE NF-KAPPAB PATHWAY Alternative NF-kappaB pathway NFKB2 CHUK MAP3K14 RELB BTRC NFKB1 DIRECT P53 EFFECTORS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%DIRECT P53 EFFECTORS Direct p53 effectors TADA2B MCL1 RGCC JMY BCL2L2 TAF9 BTG2 PPP1R13B SFN TRIAP1 SMARCA4 CX3CL1 MET AIFM2 DGCR8 ZNF385A GPX1 PMAIP1 PRMT1 DDB2 E2F3 RNF144B RRM2B IRF5 TYRP1 RPS27L PML JUN HTT PPM1J NLRC4 TP53INP1 DROSHA E2F2 PMS2 TIGAR DUSP5 ARID3A MLH1 DUSP1 CEBPZ SERPINB5 EDN2 RCHY1 TGFA PERP BDKRB2 CDKN1A SERPINE1 GADD45A IGFBP3 HSPA1B CARM1 SNAI2 EP300 EPHA2 KAT2A TSC2 TFDP1 ATF3 HDAC2 NDRG1 BCL6 NFYA BCL2L1 BCL2A1 NFYB NFYC CASP6 PIDD1 CASP1 CREBBP EGFR VDR APAF1 CSE1L SP1 COP1 DKK1 E2F1 CCNG1 BCL2 RB1 LIF MAP4K4 MDM2 CASP10 FOXA1 BID SPP1 CCNB1 VCAN FAS BBC3 MMP2 CTSD S100A2 PLK3 AFP CAV1 BAX BAK1 TP63 GDF15 COL18A1 TP53I3 CD82 TP73 PCNA DDIT4 POU4F1 STEAP3 CCNK POU4F2 PRDM1 PTEN TRRAP PYCARD SESN1 FDXR BNIP3L HGF TAP1 PRKAB1 HIC1 MSH2 DDX5 TP53 PCBP4 TP53BP2 SCN3B BCL2L14 SH2D1A TNFRSF10C TNFRSF10B TNFRSF10A APC TNFRSF10D POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%POSTTRANSLATIONAL REGULATION OF ADHERENS JUNCTION STABILITY AND DISSASSEMBLY Posttranslational regulation of adherens junction stability and dissassembly ADAM10 FYN MET ARF6 GNA13 RET SRC PTPN6 RIN2 RAB5A IGF1R HRAS RAB7A SNX1 CDH2 GFRA1 CASP3 ROBO1 SLIT1 DSP IGF2 GDNF CABLES1 PTPN1 ZBTB33 CDC42 JUP MEP1B CREBBP CBLL1 HGS EGFR TIAM1 ABL1 RAC1 NTRK2 BDNF CTNNB1 CTNND1 MMP7 EGF IQGAP1 CDH1 CTNNA1 GNA12 MMP3 NME1 DNM2 LPA4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LPA4-MEDIATED SIGNALING EVENTS LPA4-mediated signaling events RPS6KA5 ADCY9 ADCY4 ADCY3 CREB1 GNAL ADCY2 ADCY1 ADCY8 ADCY6 ADCY5 PRKACA LPAR4 PRKCE ADCY7 AURORA A SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%AURORA A SIGNALING Aurora A signaling ARHGEF7 PRKACA NDEL1 MDM2 CKAP5 RAN AURKA BRCA1 RASA1 AURKB TACC3 CENPA OAZ1 FZR1 DLGAP5 PAK1 TDRD7 GADD45A CPEB1 AURKAIP1 AKT1 PPP2R5D TP53 GIT1 BIRC5 TACC1 CDC25B AJUBA TPX2 GSK3B CD40 CD40L SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CD40 CD40L SIGNALING CD40 CD40L signaling STAT5A MAPK14 NFKB1 PIK3R6 PIK3CG PIK3CA CBLB BCL2L1 JUN MAPK9 PIK3CB IL4 TRAF1 CD40LG TRAF6 MAPK8 MAPK10 MAPK11 CD40 BIRC2 TNFAIP3 C4BPA BIRC3 JAK3 MAP3K1 FCAMR MYC TDP2 TRAF3 AKT1 MAP2K4 MAP3K14 PIK3R1 TRAF2 RELA VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED NUCLEAR ESTROGEN RECEPTOR BETA NETWORK Validated nuclear estrogen receptor beta network SMARCA4 NR0B2 SMARCE1 NR0B1 ESR2 UBA3 NCOA3 UBE2M SMARCB1 DDX54 ZNF14 NCOA1 NCOA2 NEDD8 C3 SIGNALING BY AURORA KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING BY AURORA KINASES Signaling by Aurora kinases AURKA AURKC AURKB LKB1 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%LKB1 SIGNALING EVENTS LKB1 signaling events YWHAB SIK3 SIK1 SIK2 YWHAQ SFN CREB1 TSC2 YWHAG MARK2 YWHAH MTOR RPTOR AKT1S1 YWHAZ PRKACA MAPT MLST8 TSC1 CDC37 SMAD4 ESR1 EZR MYC BRSK1 CTSD BRSK2 CRTC2 SMARCD3 CAB39 TP53 PSEN2 STK11 MAP2 MARK4 HSP90AA1 STRADA STRADB YWHAE ETV4 GSK3B STK26 EPHRINB-EPHB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRINB-EPHB PATHWAY EphrinB-EPHB pathway EPHB1 EPHB4 EPHB3 EFNB2 EFNB1 EPHB2 TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRK RECEPTOR SIGNALING MEDIATED BY THE MAPK PATHWAY Trk receptor signaling mediated by the MAPK pathway RPS6KA5 RUSC1 CREB1 MAP2K5 MAPK14 EGR1 RAP1B MAPKAPK2 PRKCD MAPK7 TRPV1 MAP3K2 BRAF ELK1 NRAS RAP1A RPS6KA1 HRAS MAP2K1 FOS CDK5R1 KRAS RAF1 MAP2K6 NTF3 MAPK1 SRF MAPK3 RIT1 EHD4 RIT2 MAP2K3 CDK5 MEF2C TNF RECEPTOR SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TNF RECEPTOR SIGNALING PATHWAY TNF receptor signaling pathway NSMAF NRK TAB2 MAP4K5 TAB1 RFFL MAP4K3 ADAM17 MAP4K2 STAT1 TNFRSF1B CYLD RACK1 PRKCZ NFKB1 MAP4K4 IKBKB CASP8 RIPK1 MAP3K5 FADD MAP3K7 PRKCI TXN IKBKG TRAF1 MAP2K7 MAP3K3 SQSTM1 BIRC2 TNFAIP3 BIRC3 MAP3K1 BAG4 CHUK MAP2K3 SMPD2 SMPD1 TRAF2 TNFRSF1A TNF TNIK RELA MADD CAV1 FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%FOXA2 AND FOXA3 TRANSCRIPTION FACTOR NETWORKS FOXA2 and FOXA3 transcription factor networks CREB1 ACADVL ALAS1 TAT DLK1 CEBPB SLC2A2 TTR UCP2 NKX2-1 ACADM HADH PCK1 F2 IGFBP1 CPT1A HMGCS1 PKLR KCNJ11 FOXF1 ABCC8 PDX1 APOA1 HNF1A NF1 FOXA1 CPT1C CPT1B FOXA3 INS GCK FOXA2 BDH1 ALB ALDOB NR3C1 TFRC G6PC1 CEBPA HNF4A SP1 CEBPD AKT1 AFP CDC42 SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CDC42 SIGNALING EVENTS CDC42 signaling events EPS8 ARHGEF7 MYL2 ARHGEF6 F2RL2 RASGRF1 DIAPH3 PRKCZ PIK3CA BRAF JUN MAPK9 PRKCE MAP2K7 MAP2K6 CDC42 ATF2 MAPK8 ENAH TIAM1 PAK1 MAPK1 DLG1 RAC1 MAPK3 MAP3K1 VAV2 MAP2K4 BCAR1 WASL CBL YES1 PLD1 MAPK14 MTOR RPS6KB1 SRC PAK4 HRAS ARPC1B ARHGDIA ACTR3 ACTR2 IQGAP3 RAF1 PAK2 ARPC4 PAX6 ARPC5 HES5 BAIAP2 SEPTIN2 TNK2 ARPC2 CDC42BPA ARPC3 MAP3K11 PARD6A CTNNB1 CFL1 IQGAP1 CDH1 MAP2K3 CTNNA1 LIMK2 EXOC7 LIMK1 PIK3R1 APC GSK3B P38 SIGNALING MEDIATED BY MAPKAP KINASES%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%P38 SIGNALING MEDIATED BY MAPKAP KINASES p38 signaling mediated by MAPKAP kinases YWHAB RAF1 YWHAQ CREB1 SFN TSC2 MAPK11 YWHAG MAPK14 YWHAH ETV1 LSP1 SRF MAPKAPK3 MAPKAPK2 YWHAZ TCF3 TH CDC25B YWHAE HSPB1 CXCR4-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CXCR4-MEDIATED SIGNALING EVENTS CXCR4-mediated signaling events JAK2 STAT5A VAV1 STAT1 STAT3 PDPK1 RAP1B RACK1 BAD PRKCZ CXCR4 CD4 PIK3CA DNM1 CD3G CD3D MAPKAP1 PIK3CB MLST8 RICTOR HLA-DRA CD247 HLA-DRB1 CDC42 PAK1 RAC1 AKT1 ITCH MMP9 RHOA BCAR1 STAT2 GRK2 ARRB2 RHOC RHOB FYN INPP5D YES1 ARR3 BLK STAT5B MTOR GNA13 PIK3R6 LYN PIK3CG SRC PTPN6 PXN FGR HCK PLCB2 FOXO1 SSH1 PTPN11 PTPRC GNG2 PTK2 LCK PLCB3 CSK GNB1 PLCB1 GNAI3 HGS GNAI1 CRK CXCL12 RALB PAG1 RGS1 VPS4B VPS4A GRK6 CFL1 UBQLN1 LIMK1 GNAO1 GNAZ PIK3R1 CD3E GNAI2 PRESENILIN ACTION IN NOTCH AND WNT SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PRESENILIN ACTION IN NOTCH AND WNT SIGNALING Presenilin action in Notch and Wnt signaling AXIN1 ADAM10 NOTCH1 CCND1 DTX1 TAB1 DLL1 RBPJ NEDD4 DVL1 CTBP1 CSNK2A1 HDAC1 JUN TLE1 FOS HNF1A MAP3K7 LRP6 WIF1 CREBBP MAPK1 FZD1 CSNK1A1 MAPK3 BTRC MYC CTNNB1 NKD1 FRAT1 PSENEN PPP2R5D DKK2 NLK PSEN1 FBXW11 WNT1 APH1A TLE5 KREMEN2 NCSTN DKK1 APH1B APC GSK3B VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%VALIDATED TRANSCRIPTIONAL TARGETS OF TAP63 ISOFORMS Validated transcriptional targets of TAp63 isoforms YWHAQ ADA ITGA3 JAG1 PMAIP1 PRKCD PML IKBKB MDM2 SERPINB5 CABLES1 PERP CDKN1A GPX2 ABL1 GADD45A FAS IGFBP3 BTRC WWP1 BBC3 CHUK ITCH EP300 FLOT2 S100A2 SMARCD3 PLK1 SHH AEN BAX CLCA2 TP63 MFGE8 GDF15 EGR2 TP53I3 ITGB4 HBP1 VDR FDXR SP1 OGG1 NOC2L DST DICER1 TRAF4 SPATA18 EVPL NQO1 TFAP2C CDKN2A SSRP1 DHRS3 IFN-GAMMA PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IFN-GAMMA PATHWAY IFN-gamma pathway CBL IRF9 CAMK2D CAMK2A SOCS1 JAK2 DAPK1 STAT1 CAMK2B STAT3 MTOR RAP1B CEBPB PRKCD PIK3CA IL1B RAP1A MAP2K1 PTPN11 IFNGR1 IRF1 PIAS1 IFNG CASP1 CALM3 CREBBP MAPK1 CRKL SMAD7 PTPN2 MAP3K11 MAPK3 RAPGEF1 MAP3K1 JAK1 AKT1 EP300 PIAS4 PIK3R1 CAMK2G PTGES2 ARF1 PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%ARF1 PATHWAY Arf1 pathway KDELR1 GOSR2 GBF1 USO1 CLTB AP2A1 ARFGAP1 GGA3 PIP5K1A ARFIP2 AP2M1 PLD2 RAC1 ARF1 CD4 COPA CLTA CYTH2 ASAP1 IL1-MEDIATED SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%IL1-MEDIATED SIGNALING EVENTS IL1-mediated signaling events TAB2 TAB1 IL1RN ERC1 TICAM2 PRKCZ IL1R2 NFKB1 IRAK3 TOLLIP PIK3CA UBE2V1 JUN IL1B IKBKB UBE2N MAP3K7 PRKCI IKBKG MAP3K3 IRAK1 TRAF6 SQSTM1 CASP1 MAP2K6 MAPK8 IRAK4 IL1RAP CHUK IL1A MYD88 IL1R1 PIK3R1 RELA GLUCOCORTICOID RECEPTOR REGULATORY NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%GLUCOCORTICOID RECEPTOR REGULATORY NETWORK Glucocorticoid receptor regulatory network FGG SFN STAT5A CXCL8 SMARCA4 STAT1 YWHAH CSF2 EGR1 PPP5C NFKB1 IL6 PRKACA BGLAP VIPR1 SUMO2 JUN KMT5B POU1F1 POU2F1 SMARCC2 FKBP5 MAPK9 SMARCD1 TBX21 NFATC1 IL13 FOS TSG101 NR1I3 IL2 IRF1 CGA IL4 SMARCC1 PCK2 MDM2 PBX1 CDK5R1 KRT17 IFNG MAPK8 CDKN1A MAPK10 SPI1 MAPK11 MAPK1 SELE NR3C1 MAPK3 KRT5 AKT1 EP300 KRT14 NCOA1 NR4A1 CDK5 POMC NCOA2 AFP BAX TBP CREB1 STAT5B MAPK14 HDAC2 PRKACG HDAC1 GATA3 PRL PRKACB CSN2 SGK1 CREBBP FKBP4 IL5 MMP1 TP53 ICAM1 HSP90AA1 RELA GSK3B INTERNALIZATION OF ERBB1%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%INTERNALIZATION OF ERBB1 Internalization of ErbB1 CBL LRIG1 ARHGEF7 ITSN1 SH3KBP1 SHC1 SRC PIK3CA RAB5A CBLB EPS15 NRAS DNM1 HRAS SYNJ1 TSG101 PIK3CB USP8 PTK2 UBE2D2 KRAS ZFYVE28 EPN1 UBE2D3 CHMP3 RAF1 AMPH CDC42 STAMBP GRB2 HGS SOS1 EGFR SPRY2 UBE2D1 EGF SH3GL2 PIK3R1 E2F TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%E2F TRANSCRIPTION FACTOR NETWORK E2F transcription factor network RB1 MCL1 CDKN1B CDC6 E2F3 YY1 RBBP8 E2F2 CCNA2 UXT CDKN1A PLAU MYBL2 SULT2A1 CES4A SERPINE1 TFDP2 XRCC1 MCM3 CES3 CES2 CES1 CES1P1 MYC TYMS CBX5 CES5A ORC1 E2F6 EP300 E2F7 RANBP1 RRM1 CDKN2C RRM2 DHFR CCNE2 POLA1 RYBP TFE3 PRMT5 KAT2B KAT2A CDK1 RBL1 SIRT1 TFDP1 TP73 HBP1 HDAC1 TRIM28 RBBP4 E2F4 CASP7 CCND3 E2F5 WASF1 BRCA1 RBL2 CREBBP TOPBP1 APAF1 TRRAP CEBPA SP1 CDK2 HIC1 TK1 CCNE1 ATM CDC25A E2F1 CDKN2A SMARCA2 CANONICAL NF-KAPPAB PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%CANONICAL NF-KAPPAB PATHWAY Canonical NF-kappaB pathway IKBKG UBE2D3 TRAF6 CYLD BIRC2 TNFAIP3 ERC1 BTRC NFKB1 CHUK BCL10 MALT1 ATM IKBKB XPO1 RIPK2 NOD2 TNFRSF1A PRKCA TNF RELA RAN EPHRIN A REVERSE SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%EPHRIN A REVERSE SIGNALING Ephrin A reverse signaling FYN EFNA5 EPHA5 TCR SIGNALING IN NAIVE CD8+ T CELLS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TCR SIGNALING IN NAIVE CD8+ T CELLS TCR signaling in naive CD8+ T cells B2M HLA-A VAV1 PLCG1 CD8B CD8A PRKCQ PDPK1 RASGRP2 RASGRP1 CD86 CD80 MAP3K8 PRF1 NRAS CD3G CD3D LCP2 PRKCB IKBKB PRKCE CD28 CD247 KRAS IKBKG TRAF6 GRAP2 CHUK AKT1 MAP3K14 ZAP70 CBL FYN SHC1 CARD11 PTPN6 BCL10 MALT1 RAP1A HRAS PTPRC PRKCA LCK CSK GRB2 SOS1 TRPV6 PAG1 LAT RASSF5 STIM1 ORAI1 CD3E REGULATION OF TELOMERASE%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF TELOMERASE Regulation of Telomerase CDKN1B IFNAR2 CCND1 NFKB1 JUN FOS IL2 IRF1 TERF2 IFNG ABL1 MAPK1 MAPK3 SIN3B SIN3A MYC AKT1 NCL BLM PINX1 SMG6 TGFB1 E6 PARP2 SMG5 TINF2 SAP30 TERF1 DKC1 POT1 TERF2IP PIF1 TNKS WRN ACD WT1 PTGES3 ZNFX1 HUS1 MTOR HNRNPC HDAC2 RPS6KB1 MAX RAD1 HDAC1 RAD9A RBBP4 SAP18 RBBP7 MXD1 UBE3A MRE11 NR2F2 NBN EGFR SMAD3 XRCC6 ESR1 XRCC5 EGF SP1 RAD50 SP3 ATM TERT E2F1 HSP90AA1 YWHAE REGULATION OF RETINOBLASTOMA PROTEIN%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF RETINOBLASTOMA PROTEIN Regulation of retinoblastoma protein RB1 CDKN1B CDK6 CCND1 ELF1 MET SMARCA4 CSF2 E2F3 BGLAP JUN MAPK9 E2F2 MDM2 CCNA2 ATF2 TGFB2 CDKN1A PPP2CA SPI1 MAPK11 ABL1 SMARCB1 EP300 MEF2C RUNX2 TBP SIRT1 TFDP1 MITF MYOD1 MAPK14 PPARG SUV39H1 AATF HDAC3 BRD2 CEBPB PAX3 RBP2 ATF7 CTBP1 DNMT1 HDAC1 CKM PPP2R3B TAF1 RBBP4 GSC E2F4 SKP2 CCND3 SFTPD RAF1 CREBBP CEBPA CDK4 CCND2 CEBPD CDK2 UBTF CCNE1 E2F1 CBX4 CDKN2A REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REGULATION OF CYTOPLASMIC AND NUCLEAR SMAD2 3 SIGNALING Regulation of cytoplasmic and nuclear SMAD2 3 signaling SMAD2 SMAD4 CALM3 CTDSP1 CTDSP2 SMAD3 TGFBRAP1 MAPK1 MAPK3 MAP3K1 KPNB1 PIAS4 CTDSPL NUP153 PPM1A KPNA2 NUP214 UBE2I TRAIL SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%TRAIL SIGNALING PATHWAY TRAIL signaling pathway IKBKG CFLAR MAPK8 MAPK1 MAPK3 MAP3K1 CHUK PIK3CA MAP2K4 PIK3CB TNFSF10 PIK3R1 IKBKB SMPD1 DAP3 TRAF2 CASP8 TNFRSF10C CASP10 TNFRSF10B TNFRSF10A RIPK1 TNFRSF10D FADD HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%HIF-1-ALPHA TRANSCRIPTION FACTOR NETWORK HIF-1-alpha transcription factor network MCL1 EDN1 EPO CITED2 SLC2A1 PGK1 NOS2 LDHA HIF1A EGLN1 EGLN3 COPS5 CXCR4 HMOX1 JUN BHLHE40 TF ABCG2 ID2 FOS ARNT ETS1 SERPINE1 NPM1 HNF4A AKT1 EP300 FURIN NCOA1 NCOA2 TFF3 CREB1 ENG ITGB2 GATA2 NDRG1 HDAC7 IGFBP1 BHLHE41 ADM RORA HK2 HK1 CA9 PGM1 GCK PKM PLIN2 ALDOA SMAD4 ABCB1 CREBBP PFKFB3 FECH SMAD3 BNIP3 NT5E CXCL12 LEP CP PFKL TFRC ENO1 SP1 VEGFA TERT REELIN SIGNALING PATHWAY%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%REELIN SIGNALING PATHWAY Reelin signaling pathway CBL FYN GRIN2B ITGB1 ITGA3 MAP1B ARHGEF2 PIK3CA LRP8 NCK2 RELN MAPT RAP1A DAB1 CDK5R1 PAFAH1B1 MAP2K7 MAPK8 CRKL GRIN2A MAP3K11 MAPK8IP1 RAPGEF1 LRPAP1 AKT1 CDK5 VLDLR PIK3R1 GSK3B RAPID GLUCOCORTICOID SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%RAPID GLUCOCORTICOID SIGNALING Rapid glucocorticoid signaling GNB1 MAPK8 GNAL MAPK11 MAPK9 MAPK14 GNG2 CRH SIGNALING EVENTS MEDIATED BY TCPTP%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%SIGNALING EVENTS MEDIATED BY TCPTP Signaling events mediated by TCPTP STAT6 STAT5A STAT5B MET STAT1 ITGB1 STAT3 SHC1 SRC PIK3CA KPNB1 KDR ITGA1 CSF1 PDGFRB PIK3CB GAB1 PIAS1 INS PTPN1 PDGFB INSR CREBBP GRB2 SOS1 EGFR PTPN2 CSF1R LMAN1 JAK3 JAK1 EGF HGF VEGFA EIF2A KPNA2 ATR PIK3R1 EIF2AK2 RAB4A PAR4-MEDIATED THROMBIN SIGNALING EVENTS%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%PAR4-MEDIATED THROMBIN SIGNALING EVENTS PAR4-mediated thrombin signaling events ROCK2 MYL2 GNB1 F2RL2 ROCK1 GNA13 GNA14 F2RL3 GNA15 GNAQ GNA11 F2 RHOA PLCB2 GNG2 BMP RECEPTOR SIGNALING%PATHWAY INTERACTION DATABASE NCI-NATURE CURATED DATA%BMP RECEPTOR SIGNALING BMP receptor signaling SMAD9 SMAD5 TAB2 TAB1 PPP1CA SMURF1 CTDSPL PPM1A MAP3K7 SMAD4 ZFYVE16 CTDSP1 PPP1R15A CTDSP2 MAPK1 SMURF2 SMAD7 SKI XIAP BAMBI CHRD CHRDL1 BMP4 HJV SOSTDC1 CER1 AHSG FST NOG RGMB BMP7 BMPR2 NUP214 SMAD6 BMP6 RGMA SMAD1 GREM1 BMP2 BMPR1B GSK3B BMPR1A HEDGEHOG%NETPATH%HEDGEHOG Hedgehog MED6 KIF27 SKI MED23 CDK8 SMO CTNNB1 GAS1 HEL2 DHH SDC2 HHIP IHH ARRB2 NR2E1 GLI3 MED12 CCNB1 SHH SIN3A ADRBK1 RAB23 SUFU BOC SAP18 CDON MED1 SMAD1 CREBBP PTCH1 PTCH2 DYRK1A KIF7 TCR%NETPATH%TCR TCR ITSN2 ATF2 CYFIP1 WIPF1 KIAA0142 SLA2 ENO2 CRKL GOLGA5 RPS6KA5 UBASH3B TRIM25 HOMER3 CD2AP PARD3 PRKCQ PRKD2 PRKD1 C10orf28 EPHA3 SH2D2A TXK PIK3R2 PIK4CA PIK3R1 PTTG1IP BCL10 LY9 DKFZp686J04131 LDHB INPP5D PLCG2 ICOS PAG1 LYN VASP STAT5B EGR1 CREBBP JUN FYB1 NFATC2 NFATC1 LNPEP CGN CDC2 EPRS1 REL UNC119 GRB2 GRAP ADA ITK MTMR10 FLJ00120 GDI2 CLTC CD3G SHB CD3E PTPRH CD3D IKBKB TUBA1A CTLA4 JAK3 MAP4K1 VAV3 DUSP3 SYK ANXA2 RIPK2 NFAM1 PGAM1 FCRL3 TUBB GAB2 FOS ZDHHC17 LIME1 VAV1 VAV2 RAPGEF1 ARHGEF2 AHCY WAS NEDD9 RELA Pe1Fe6 PAK1 STAT4 FLNB CCT8 MPZL1 GIT2 MAP3K1 STAT1 DKFZp686O0451 DKFZp666O0110 ERBIN DEF6 ITCH CTNNB1 CD84 CD82 HEL-S-81p CD80 DGKA SLA ARHGAP35 HEL-S- SIT1 GRAP2 ARHGDIB MAP3K8 KIRREL1 MAP2K1 SCAP2 MAP2K2 CISH DYRK1A DYRK1B ANXA11 PRPF4B LAX1 TUBA4A ACLY DOK1 CD8A HGS NCL ELMO1 ADAM9 PKP4 RAF1 STAM2 KHDRBS1 TSG101 SHC1 PXN STK39 DTX1 STK4 SDCBP RAP1A CASKIN2 LPXN BMF FLJ00308 HEL-S-133P NFKB1 NFKBIA PTPRC PTPRA DKFZp434N041 LAT NFKBIB DKFZp434N101 GSK3B DDX3X DDX49 HSP90AB1 PTPN22 PIK3C2B CABIN1 PSTPIP1 YWHAQ ZNF404 NCK1 CHUK MSL2 YWHAZ ACTA1 ZAP70 CREB1 LCK TRAF6 PECAM1 C9orf78 EVL LCP2 SOS1 DOCK2 SOS2 CRK CEBPB SRC ATP1A1 CBL HDAC7 CDC42 DNAJB1 MAPK9 MUC1 MAPK8 MAPK7 PTK2B MAPK1 FYN SH2B3 WASF2 MAPK3 TRAT1 PTPN11 MAPK14 CD2 MAPK11 EIF3M TEC RPS6KB1 CD5 CD7 PTPN6 CD247 RAN BCR%NETPATH%BCR BCR CCNA2 ZAP70 RAP2A CREB1 BANK1 LCK RAPGEF1 HCLS1 LCP2 SOS1 SOS2 CRK HDAC5 WAS NEDD9 CBL RELA HDAC7 MAPK9 MAPK8 CCL4 CCL3 MAPK1 PTK2B CSK FYN SH2B2 MAPK4 MAPK3 PTPN18 CD72 CMTM3 PLEKHA1 PLEKHA2 STAT1 DKFZp666O0110 STAT3 ATP2B4 PTPN11 MAPK14 TEC RPS6KB1 CD5 BAX CTNNB1 FOSB PTPN6 FCGR2B RB1 ATF2 IFITM1 CD81 SLA2 CRKL CCND3 TCL1A CCND2 RPS6KA1 PIP4K2A PIP4K2B JUNB MAP3K7 GTF2I MAP2K1 MAP2K2 PRKCB PRKCE RPS6 DOK1 DOK3 CCNE1 MAPKAPK2 BTK PRKCQ PRKD1 RAF1 BLK SHC1 ITPR2 DAPP1 PIK3R2 PIK3R1 BCL10 FOXO3 FOXO1 RASGRP3 CD79B CD79A BCL2L11 CD19 INPP5D BTLA PLCG2 EIF4EBP1 PIP5K1A FLJ00308 PIP5K1C LYN VASP JUN NFATC3 NFATC2 BRAF NFKB1 NFKBIA CDK7 CDK6 PTPRC BCL6 CDK4 BRDG1 CDK2 BCL2 REL CYCS GRB2 CD22 DKFZp434N101 GSK3B ITK GSK3A FLJ00120 PIK3CD STM7 IKBKB CASP9 CASP3 BLNK IKBKG NCK1 MAP4K1 CR2 SYK CHUK PDPK1 RRAS2 FOS GAB2 LIME1 VAV1 VAV2 LAT2 IL1%NETPATH%IL1 IL1 NFKBIB DKFZp434N101 RB1 ATF2 GSK3B IL1RN IRS1 IKBKAP ECSIT IKBKB HSPB2-C11orf52 PPP6C HEL-S- SIRPA IKBKG MAP3K7 MAP2K3 MAP2K4 MAP2K1 MAP2K2 FBXW5 CHUK IL1R1 IL1R2 IRAK3 IRAK4 IL1A DOK1 TRAF6 IL1B PELI1 UBE2V1 SQSTM1 PIK3R2 PIK3R1 PRKCZ DKFZp686J04131 RELA MAPK9 ACAN MAPK8 IRAK1 IRAK2 MAPK1 MAPK3 MAP2K6 MAP3K2 JUN STAT3 PTPN11 MAPK14 S100B EIF2S1 NFKB1 NFKBIA MAP3K7IP1 DKFZp781H1925 REL TAB3 MYD88 IL2%NETPATH%IL2 IL2 FYN EIF4E MAPK3 LYN STAT5B JUN BAD STAT1 STAT3 PTPN11 NMI MAPK14 IL2 NFKB1 MTOR RPS6KB1 IL2RA CDK2 IL2RB BCL2 PTPN6 GRB2 ATF2 IRS1 PIK3CD YBX1 SHB NR3C1 ETS2 CRKL JAK3 JAK1 MAP2K1 MAP2K2 CISH SYK IL15 RPS6 GAB2 VAV1 CREB1 EIF3S9 PIK3CA CCNE1 LCK SOS1 RAF1 PLCB1 SGK1 STAM2 CRK SHC1 PIK3R3 PIK3R2 PIK3R1 CBL FOXO3 IL2RG PRKCZ RELA SOCS3 MAPK8 SOCS1 TERT MKNK1 STAT4 EIF4EBP1 PTK2B MAPK1 IL3%NETPATH%IL3 IL3 PPP2CA SOCS2 SOCS3 PAK1 MAPK8 RXRA BCL2L11 INPP5D MAPK1 FYN MAPK3 LYN STAT5B BAD KCNIP3 DKFZp666O0110 STAT3 PILRB PTPN11 MAPK14 NFKB1 IL3 TEC PTPRC FES BCL2 BAX PTPN6 GRB2 BCL2L1 ATF1 RB1 ATF2 GSK3B GSK3A HEL114 PIK3CD CRKL PPP3CA YWHAQ HEL-S-1 HRAS JAK1 HEL-S-102 MAP2K1 FCER1G CISH SYK PRKCB PRKCA TYK2 GAB2 YWHAZ VAV1 DOK1 CREB1 LCK IL3RA RARA RAPGEF1 RAF1 SOS1 CRK SRC SHC1 PXN CSF2RB PIK3R2 PIK3R1 GATA2 CBL FOXO3 GATA1 FOXO1 IL4%NETPATH%IL4 IL4 MAPK11 RPS6KB1 FES PTPN6 GRB2 BCL2L1 DKFZp434N101 ATF2 CD40 SPI1 IRS1 PIK3CD IKBKB EP300 JAK3 JAK1 IL13RA1 SYK CHUK IL13 -4 TYK2 GAB2 SND1 PIK3CA LCK BTK SOS1 CEBPA CEBPB SHC1 CXCR4 PIK3R2 PIK3R1 CBL IL2RG PRKCZ RELA SOCS3 MAPK8 GRK3 H3C15 SOCS1 INPP5D PLCG2 MAPK1 FYN STAT6 SOCS5 MAPK3 STAT5B CREBBP BAD STAT1 DKFZp666O0110 STAT3 PTPN11 MAPK14 NFKB1 NFKBIA IL4 IL5%NETPATH%IL5 IL5 GSK3B ATF2 GSK3A IL5RA CRKL RPS6KA1 HRAS SOX4 JAK1 MAP2K2 SYK PRKCB YWHAZ VAV1 RAPGEF1 BTK HCLS1 RAF1 SOS1 SHC2 SHC1 CSF2RB PIK3R2 PIK3R1 CBL FOXO3 SDCBP SOCS1 ALOX5 MAPK1 PTK2B SH2B2 MAPK3 LYN STAT5B JUN STAT1 STAT3 PTPN11 MAPK14 NFKB1 NFKBIA IL5 IL2RB CTNNB1 UNC119 BAX PTPN6 GRB2 IL6%NETPATH%IL6 IL6 INPP5D ERBB2 EIF4EBP1 PTK2B MAPK1 FYN EIF4E MAP2K6 MAPK3 LYN STAT5B CREBBP JUN STAT1 BAD DKFZp666O0110 STAT3 PTPN11 MAPK14 BMX c-fgr NFKB1 CDK9 NFKBIA IL6 TEC CDK5 RPS6KB1 FES GRB2 DKFZp434N101 RB1 GSK3B CD40 INPPL1 RPS6KA2 SIRPA EP300 HNRPA1 RAC1 HRAS IL6R MAP3K7 EIF2A JAK1 NCOA1 MAP2K4 HEL-S-102 MAP2K1 MAP2K2 TYK2 HNF1A FOS GAB2 VAV1 BTK IL6ST SOS1 SGK1 CEBPB HDAC1 SHC1 PXN PIK3R2 FOXO4 PIK3R1 CBL FOXO3 NLK FOXO1 SOCS3 MAPK8 ERBB3 IL-7%NETPATH%IL-7 IL-7 MAP2K2 BAD SHC1 STAT1 IRS1 CLTC STAT3 PIK3R1 FOXO3 IL2RG FOXO1 IL7 MAPK1 PTK2B FYN IL7R JAK3 MAPK3 JAK1 STAT5B GSK3B GSK3A MAP2K1 ALPHA6BETA4INTEGRIN%NETPATH%ALPHA6BETA4INTEGRIN Alpha6Beta4Integrin PTPN11 MAPK14 MTOR EIF6 ARHA GRB2 TP73 HEL2 RTKN IRS1 ITGB4 HEL113 PIK3CD LAMC2 LAMC1 MYLK3 YWHAQ CASP3 HEL-S-1 RAC1 EPHB2 DSP DST RPSA PRKCA FOS YWHAZ PIK3CA ITGA6 PLEC COL17A1 LAMA5 CD151 SHC1 LAMA1 SRC LAMA3 PIK3R3 PIK3R2 PIK3R1 NTN1 EGFR PAK1 ERBB2 EIF4EBP1 CLCA2 MAPK1 CLCA1 FYN SFN EIF4E MAPK3 SMAD2 JUN YES1 LAMB3 BAD LAMB2 DKFZp666O0110 ERBIN LAMB1 IL9%NETPATH%IL9 IL9 TYK2 PIK3R1 IL2RG HEL-S- IL9 MAPK1 GRB2 STAT6 JAK3 HTATIP IL9R MAPK3 JAK1 STAT5B MAP2K1 MAP2K2 SHC1 IRS1 STAT1 STAT3 PTPN11 RANKL%NETPATH%RANKL RANKL RELA EGFR RELB MAPK9 MAPK8 MITF-C PLCG2 EIF4EBP1 MAPK1 FYN MAPK3 MAP2K6 LYN JUN BAD STAT1 DKFZp666O0110 NFATC1 PILRA MAPK14 MTOR NFKB1 NFKB2 SMARCA4 NFKBIA MAP3K7IP1 CYLD RPS6KB1 RPS6KB2 REL PTPN6 DKFZp434N101 ATF2 SPI1 FHL2 TREM2 SIRPB1 FCAR HEL-S-89n IKBKB FCGR3A FCGR3B TNFSF11 MAP3K8 IKBKG ATP6V1E1 MAP3K7 JAK1 VAV3 MAP2K1 SYK CHUK HEL-S-72p TRAF2 TRAF1 GAB2 ETV5 OSCAR RUNX1 TYROBP CREB1 TRAF3 TRAF6 TRAF5 SQSTM1 PRKAA1 CEBPB PRKAA2 SRC PIK3R2 TNFRSF11B TNFRSF11A PIK3R1 FOXO4 CBL LEPTIN%NETPATH%LEPTIN Leptin PRKCE HEL-S-269 RPS6 PRKAB1 RUNX2 GAP43 MMP14 CREB1 LCK MAPKAPK2 RAF1 CD44 CRP KHDRBS1 PRKAA1 PRKAA2 SHC1 SRC PIK3R2 PIK3R1 PRKCZ ACACB FOXO1 EGFR RELA ACACA SOCS2 SOCS3 MAPK8 ERBB2 PLCG2 EIF4EBP1 MAPK1 FYN SOCS7 EIF4E SH2B1 MAPK3 MAP2K6 STAT5B BAD STAT1 DKFZp666O0110 LIMK1 STAT3 PTPN11 MAPK14 NFKB1 MTOR NFKBIA CDK5 RPS6KB1 SP1 GNAQ LEP SP3 REL PDE3A GRB2 ATF1 DKFZp434N101 ATF2 GSK3B GSK3A ITGB5 IRS1 PTEN IRS4 SLC2A4 IGF1R IKBKB HSPB2-C11orf52 RPS6KA2 CFL2 RPS6KA1 LEPR EP300 IKBKG JAK3 JAK1 MAP2K3 NCOA1 HEL-S-102 PRKAB2 MAP2K1 MAP2K2 CISH CSNK2A1 CHUK TSH%NETPATH%TSH TSH GNA11 EIF4EBP1 MAPK1 CGA MAPK3 MAP2K6 VASP STAT1 KCNIP3 DKFZp666O0110 STAT3 MAPK14 TSHR MTOR NFKBIA GNAO1 ARHA RPS6KB1 CDK4 GNAQ APEX1 LEP CDK2 PPP1R1B GNAS NFKBIB RB1 ATF2 ARF1 CDKN1B HEL-S-89n IGF1R IKBKB CCND3 RPS6KA1 HMGN2 HRAS TSHB JAK1 HMGN1 MAP2K3 MAP2K1 ANXA1 DKFZp686N0152 PDPK1 PDE4D RPS6 HEL-S-72p PRKCA SCRIB CREB1 hEMMPRIN PIK3CA CCNE1 AKT1S1 CANX RAF1 SRC SHC1 GNAI3 CREM PIK3R2 PIK3R1 ATP1A1 HEL-S-99n PRKCZ RAP1GAP RELA GNAI1 GNA13 SOCS3 SOCS1 TSLP%NETPATH%TSLP TSLP LCK PABPC1 LCP1 DOCK2 PLEC HEMGN KDM3B SRC WIZ ADD3 RELA ADD1 RELB MAPK9 MAPK8 PUF60 LMNA FAM120A STAT4 MAPK1 FAM63A FYN STAT6 EIF4E SRSF11 BRD4 CLASP2 MAPK3 PTPN18 SEPTIN1 STAT1 SEMA4B STAT3 PTPN11 MAPK14 TPD52L2 GATAD2B MAPK10 TEC RLIM PTPN6 CRLF2 ITSN2 RPL4 ATF2 MDC1 CD84 CRTC2 OXTR TMEM41B WIPF1 PANK1 CTNND1 INPPL1 ICAM2 MKI67 RPL7 STK10 CHEK1 JUNB SCAP2 MAP2K1 MAP2K2 SP110 RPS6 hCG_2011153 hCG_2044638 KNL1 LARP4B TEX2 HCFC1 PSPC1 MADD BTK ATF7 TAGLN3 TLN1 OPTN TMEM63A SHC1 BOD1L1 DAPP1 CDCA8 CSF2RB ZC3HAV1 FOXO3 DKFZp686P17171 MTDH ARHGAP21 DKFZp781J211 EIF4EBP1 C9orf129 LYN VASP STAT5B YES1 TSLP NUP153 PUM1 TJAP1 NFKB1 ZZEF1 NFKB2 NFKBIA EPRS1 FES UBE2O RPS20 PIN4 IL7R CALM2 DIDO1 AHCTF1 MTMR10 NUMA1 PPP1R11 ITGB3 CHD8 IRF2BPL DKFZp686M02159 NELFA CIC RBM7 JAK1 CDV3 WDR36 FCER1G CAD NAV1 GAB2 ETV3 WDR33 RNF168 MED24 PIK3CA FSH%NETPATH%FSH FSH HEL-S-102 MAP2K1 MAP2K2 FSHB -4 RPS6 TSC2 MAPK14 DKFZp686K0257 MTOR CREB1 PRKAR1A FSHR MDM2 RARA RAF1 SGK1 PRKAA2 SRC ARRB2 ARR3 FOXO3 EGFR FOXO1 RELA RPS6KA3 HEL-S- YWHAQ GRK4 ADRBK1 EIF4EBP1 MAPK1 CXNK2 FYN CGA APPL1 MAPK3 ANDROGENRECEPTOR%NETPATH%ANDROGENRECEPTOR AndrogenReceptor PPP1R14A HEL-S-102 CREB1 HDAC1 DKFZp666O0110 PIK3R1 NOTCH%NETPATH%NOTCH Notch HES1 HES5 MAPK3 JAG2 SPEN SMAD1 STAT3 WDR12 NFKB1 ITCH SNW1 CNTN1 TCF3 APP GSK3B MAML2 MAML1 FHL1 DKFZp586H0919 RBPJ YY1 LFNG SIN3A POFUT1 HEY2 MAGEA1 EP300 CIR1 SKP2 SKP1 DKFZp762E1511 PSENEN HES6 MEF2C FBXW7 ADAM10 RBX1 SAP30 NCOR2 KAT2B ADAM17 NCOR1 NOV LCK MFNG NUMB DKFZp434N181 NOTCH3 HDAC2 NOTCH1 SRC HDAC1 PSEN2 DTX1 FURIN PIK3R2 PIK3R1 PSEN1 ASCL1 RELA DLL3 DLL4 APH1B BLOC1S1 MAPK1 EGFR1%NETPATH%EGFR1 EGFR1 ATF1 ITSN2 USP6NL RPL30 ARAF KIAA0142 TFG UBASH3B MYC PLCE1 ANKS1A PRKCI PRKCB SCRIB PRKCA FRS2 FRS3 SCAMP3 KIAA1217 ZFYVE16 PRKAR1A PARD3 PRKD1 RBCK1 CTBP1 PRKCZ SLC5A5 MYO6 PLCG2 COX2 S100A14 S100A10 LYN JUN JUND JUP BRAF CDC2 CYLD TRIP6 PYGB ARF4 RPLP0 CLTC CLTA SHB ARHGAP5 ENSA PLEKHN1 APPL2 JAK1 APPL1 SERPINB3 ANXA1 ANXA2 PGAM1 ANXA4 EPS15L1 FOS PLSCR1 GPRC5A HEL-S-87p PHLPP1 AHNAK HTT RPS27L SNX33 EGFR DKFZp686B23205 ADRBK1 AP2S1 RICTOR FLNB RPS2 LDLR /KNS-.3 STAT1 STAT2 DKFZp686O0451 DKFZp666O0110 STAT3 HIPK2 DCBLD2 ARHA PKN2 FRK CDKN3 CTNND1 LAPTM4A C11orf52 STK11 CYSRT1 GRB14 CDH2 GRB10 MAGI1 MAP2K3 MAP2K1 MAP2K2 DYRK1A DYRK1B PRPF4B TOM1L2 HAT1 PKP2 ADAM9 PKP4 PKP3 PHLDB2 COL17A1 KHDRBS1 SHC1 FOXO4 FOXO1 SOCS3 ATXN2 RAP1A SOCS1 HNRNPDL EIF4EBP1 ABL2 MAP2K5 TNK2 RFXANK NFKB1 PTPRE CDK5 PTPRA SP1 CDK2 ALB BCL2 RAB5A EIF4G1 DKFZp434N101 ITGB1 HEL-S-112 ITGB4 CALCOCO2 HEL-S-115 PTEN PIK3CD PIK3C2B NCK2 CCDC50 NCK1 ACTR3 DSP ACTR2 PDCD6IP KSR1 -4 PIK3CA LCK DSG2 SOS1 CRK SOS2 SLC25A6 CEBPA PRKAA1 CEBPB PRKAA2 SRC WBP2 HDAC1 ITLN2 SRI TENC1 CDC42 SLITRK6 FYN CSK RBBP7 SH2B1 PTPN1 PTPN18 PPP1R14B PTPN11 BAIAP2 MTOR PTPN6 TIEG2 PTPN5 NECTIN1 SPG20 ERRFI1 APP AHCYL1 ZDHHC5 HEL113 CBLC HEL114 ANTXR1 CRKL RPS6KA3 DKFZp434G2016 BAIAP2L1 RPS6KA5 SNRPD2 TRIM29 RPS6KA2 RPS6KA1 EPHB2 TNS4 TNS3 RPS10 EPHB1 SLC12A7 EPHB4 TNS1 EPHB3 EPHA4 ACTN1 KRT7 KRT5 ACTN4 GAREM1 TLN1 RIN1 PFN1 EPHA1 EPHA2 GRB7 SDC4 STXBP1 SH2D2A SDC3 PIK3R3 PIK3R2 PIK3R1 PTTG1IP DKFZp686J04131 MYL12B CXNK2 STX4A SNX5 VASP STAT5B HEL107 INSR SIAH2 SIAH1 PTK6 SMU1 WNK1 SDC1 GRB2 CALM2 CC2D1A AP2A1 PTPRK WASL LIMD1 PTPRF PS1TP5BP1 OTUD6B RAC1 HRAS VAV3 MAP4K1 CDV3 MINK1 TYK2 GAB2 DKFZp686K0257 VAV1 VAV2 CEACAM1 KIT ARHGEF5 CSTB NEDD9 PRKX RELA PAK1 PDZD11 CD59 MPZL1 MAP3K2 GIT2 MAP3K1 CAVIN1 CAVIN2 HUWE1 PLEKHA5 ERBIN PLEKHA6 ITCH KRT18 AXL NEDD4 EPPK1 SH3GL3 NDUFA13 INPPL1 ARHGAP35 ARHGAP42 HEL-S- SIRPA hCG_1991735 KRT6A RALBP1 KIRREL1 EEF1A1 DOK1 ADAM17 HGS EEF1A2 ELMO2 RAF1 STAM2 HEL-S-132P PXN DAPP1 LPP PLD2 EFNB2 SDCBP UBB CALD1 CASKIN2 RIPK1 SMAD2 HEL-S-94n HSPA4 CAV2 CRIM1 HEL-S-133P DKFZp686A13234 GSK3B DYRK4 DYRK3 GSK3A DOCK4 DDX3X USP31 RBM3 CASP9 FLOT1 FLOT2 HEL-S-1 HNRPA1 TGIF1 PDPK1 LSR ARAP1 YWHAZ EPN1 EPN2 EPN3 ACTA2 SFPQ CREB1 ELF3 MYH9 DOCK1 PLEC RALA RALB MVP RGS16 CAMK2A ASAP1 ATP1A1 CBL MAPK9 MAPK8 MAPK7 MARVELD2 ERBB3 ERBB2 REPS2 MAPK1 PTK2B MTA2 PDLIM4 MAPK3 SNCA BAD EGF SPRY4 PPP2R3A MAPK14 RPS6KB1 DKFZp451F1115 FAM62A SPRY2 SPRY1 KRAS DNCL1 ZPR1 ID%NETPATH%ID ID ID4 MYF6 ID3 TCF4 TCF3 RAF1 ATF3 MYF5 RB1 FHL2 ETS2 ELK3 IFI16 PSMD4 MAPK1 HES1 MAPK3 MYOG TCF7L2 MAP2K1 MAP2K2 SMURF2 TCF12 OLIG1 OLIG2 PAX5 PAX2 RBL2 RBL1 PAX8 ID2 MYOD1 ID1 CDK2 KITRECEPTOR%NETPATH%KITRECEPTOR KitReceptor PRKCA GAB2 VAV1 DOK1 DOK3 PIK3CA KIT BTK EZR SOS1 RAF1 CRK RAB7A GRB7 SHC1 SRC WAS PIK3R2 CSF2RB PIK3R1 CBL FOXO3 RELA Pe1Fe6 PAK1 MAPK8 SOCS1 MITF-C INPP5D PLCG2 EIF4EBP1 MAPK1 FYN SOCS6 MPDZ SH2B3 SH2B2 MAPK3 SOCS5 LYN DKFZp686J1568 STAT5B JUN YES1 FYB1 BAD STAT1 RDX STAT3 NFATC2 PTPN11 TNFRSF10A MAPK14 c-fgr EPOR MTOR KITLG TEC RPS6KB1 FES BRDG1 CDK2 GRB2 PTPN6 GRAP IL7R LAT MAD2L1 DKFZp434N101 PTPRU GSK3B ATF2 GSK3A WIPF1 CLTC CRKL DKFZp686M02159 GYS1 SPRED1 RPS6KA1 GRB10 EP300 JAK3 HRAS HEL70 ACTR2 SCAP2 MAP2K1 MAP2K2 PRKCB RPS6 MATK TGF_BETA_RECEPTOR%NETPATH%TGF_BETA_RECEPTOR TGF_beta_Receptor PIAS2 RBX1 RUNX1 PIAS1 DKFZp762H177 EID2 ZFYVE16 PRKAR1B CCNE1 HGS EWSR1 PARD3 ANAPC5 SIK1 RAF1 ATF3 ANAPC1 CSNK1G2 ANAPC2 DDX5 SHC1 SDC2 FOXG1 PXN PIK3R2 FOXO4 PIK3R1 FOXO3 ANAPC10 FOXO1 CCNB2 SNX4 SNX1 SNX2 DVL1 EIF4EBP1 SKIL SPTBN1 MAP2K6 SNX6 SMAD2 WWTR1 CREBBP JUN SMAD4 JUND UBE2I TGFB1 SMURF2 STK11IP SMURF1 IRF2BP1 DKFZp781N011 NUP153 SMAD6 NFKB1 CDC2 NFKBIA CDK6 SNW1 COPS5 CDK4 SP1 CDK2 TCF4 GRB2 DYNLRB2 DCP1A TP73 ITGB1 ACVRL1 GSK3B CDKN1A CITED1 DKFZp451O0517 ITGB3 BRCA1 CTCF ARRB2 MED15 IKBKB XPO4 SUMO1 MAP4K1 NCOA1 TGIF1 KLF10 CHUK PDPK1 HEL-S-72p AXIN1 OLIG1 AXIN2 FOS TGFBR1 UCHL5 TGFBR2 PJA1 RBL2 TGFBR3 KAT2B ZEB2 EIF3S2 TFDP1 RBL1 TFDP2 PIK3CA TRAF6 SOS1 CRK CD44 ENG PPP1R15A CAMK2D ROCK1 HDAC1 SRC CAMK2A PPP2CA MAPK8 FZR1 PARD6A STAMBPL1 CTNNA1 MAPK1 E2F4 CTNNA2 E2F5 CAMK2G DYNC1I1 SAMD3 MAPK3 NR1i1 NFYA NFYB NFYC DKFZp666O0110 ERBIN WWP1 MAPK14 MTOR PML FKBP1A SKI MAP3K7IP1 ITCH RPS6KB1 ARHA CTNNB1 FOSB RB1 ATF2 SPARC ZFYVE9 UBE2D2 UBE2D3 DKFZp586H0919 UBE2D1 PPP2R2A NR2A1 PPP1CC HOXA9 STK11 RPS6KA5 CDC23 FNTA CCND1 PPP2R1A MYC CDC27 EP300 SNIP1 SOX9 JUNB MAP3K7 RNF111 VPS39 SKP1 MAP2K3 NUP214 MEF2C MAP2K1 MAP2K2 FOXH1 RUNX3 RUNX2 WNT%NETPATH%WNT Wnt DIXDC1 DKFZp586H0919 FZD10 DKFZp434G2016 FRAT1 FRAT2 SOX1 HEL-S- CCND1 CDH2 MAP3K7 MAP2K4 PRKCH WNT5B PRKCB PRKCE PRKCA CSNK1D CSNK1E DKK1 SFRP4 SFRP1 DAAM1 PRKCQ ROR1 ROR2 RAF1 PI4K2A CTBP2 CTBP1 NLK SLC9A3R1 DVL1 DVL2 WNT1 WNT3 WNT4 FZD1 SMAD1 FZD3 JUN GCKR YES1 FZD2 JUP SETDB1 FZD5 WNT3A FZD4 FZD7 FZD9 FZD8 NFATC2 DKFZp781N011 BCL9 CDK6 PPP1R1B PIN1 CHRFAM7A TCF4 TCF3 GSK3B GSK3A ARRB2 DKFZp586M1622 STM7 RSPO3 HEL-S-1 RSPO1 RAC1 AXIN1 WNT9B KREMEN1 AXIN2 WNT9A PAX2 PPARG SRC LRP5 MESD LRP6 PPP2CA MAPK8 WNT11 WIF1 FRZB GPC3 MAPK1 MAPK3 TCF7L2 MAP3K1 CSNK1A1 RYK WNT7B WNT7A APC ARHA RPS6KB2 CTNNB1 TNFALPHA%NETPATH%TNFALPHA TNFalpha RPL4 RB1 RPL30 RPL8 DCAF7 RPL6 HEL-S-89n MYLK PSMD6 RPS6KA5 PSMD7 TBK1 PSMD2 PSMD3 DPF2 PSMD1 PIG59 RPS11 JUNB RPS13 SKP1 SMARCC1 SMARCC2 CSNK2A1 PRKCE PRKCA CDC34 MYL2 CDC37 TXNIP PRKCQ TRIB3 PIK3R2 KIAA0287 PIK3R1 TXN PRKCZ DKFZp686J04131 GLG1 FADD CREBBP JUN CRADD DKFZp781N011 DKFZp566E044 SMARCA4 REL GRB2 FAF1 OTUD7B IKBKAP PYGL IKBKB CASP10 NKIRAS1 NKIRAS2 IKBKG IKBKE MAP4K2 SYK RIPK3 HEL-S-72p ACTL6A COMMD1 MUXA ARHGEF1 ARHGEF2 AKAP8 TANK RELA EGFR RELB PAK1 RXRA FLNA MAP3K2 MAP3K1 STAT1 DKFZp666O0110 LRPPRC KTN1 MAP3K7IP1 ITCH PSMC1 PKN1 hCG_16983 HEL2 IRS1 TNF-alpha UBE2D2 UBE2D3 hCG_20684 FBL HEL-S- KPNA6 PAPOLA EP300 TNFRSF8 MAP3K8 KPNA2 MAP3K7 KPNA3 GTF2I MAP3K5 MAP2K4 MAP2K1 FBXW7 USP2 CYBA TRAIP DOK1 TXLNA FANCD2 MADD MAPKAPK2 FKBP5 NSMAF COPB2 PSMD12 PSMD13 DIABLO TNFRSF11A FOXO1 BAG4 BRINP1 G3BP2 RIPK1 MAP2K5 MAP2K6 SMAD2 UBE2I SEC16A TRAPPC9 MCC NFKB1 NFKB2 NFKBIA CDK9 IRAK1BP1 COPS5 CDK5 TAB3 ALPL NFKBIE MAP3K11 NFKBIB BCL2L1 RNF11 DDX3X HSP90AB1 MCM7 TRADD TNFAIP3 HMGB1 CASP9 PPP6C SUMO1 YWHAQ BCL7A PPP1R13L CASP3 NFKBIZ HEL-S-1 YWHAG HEL-S-101 HEL-S-102 APAF1 CHUK EED -4 TRAF2 TRAF1 TNFRSF1B YWHAZ TNFRSF1A CREB1 TRAF4 RASA3 POLR1A TRAF3 TRAF6 POLR1C TRAF5 POLR1D PFDN2 MCM5 SOS1 SOS2 BIRC2 BIRC3 HDAC2 SRC HDAC1 USP11 MTIF2 NR2C2 MAPK9 MAPK8 ERBB3 ERBB2 TIFA MAPK1 ROMO1 POLR2H RFFL MAPK3 POLR2L SMARCE1 RNF25 PTPN11 ZA20D2 MAPK14 MTOR PML RPS6KB1 PRC1 TNIP2 BAX TBKBP1 PDCD2 TRIM32 5-ARACHIDONYLGLYCEROL_BIOSYNTHESIS%PANTHER PATHWAY%P05726 5-arachidonylglycerol_biosynthesis Plcb3 DAGLA LPL Lpl Pla1a Plcb2 Plcb1 PLCB3 Dagla LIPH PLCB1 PLCB2 PLA1A 5HT1 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04373 5HT1 type receptor mediated signaling pathway Kcnk9 LOC112204126 gnb3b gnb3a 1281793 gpbA aex-4 KCNK3 gnai2a gnai2b gnb1 gnb2 pkaC PRKACG DICPUDRAFT_93216 gnai3 PRKACA gnai1 PRKACB gpb-2 gpb-1 pkac1 Prkx gnaia Gbeta13F gnb1b LMJF_35_3960 Pka-R2 BRAFLDRAFT_60318 Pka-C1 Pka-C3 Gng10 Gnao1 gsto1 Gbeta76C GNG10 8035476 Galphai PRKAR2B PRKAR2A BRAFLDRAFT_220697 prkacbb prkacba nSyb kcnk3a SNAP-25 kin-1 Gngt2 HTR1E HTR1F HTR1D HTR1A HTR1B GNG12 GNG11 Snap29 GNAO1 Snap24 Snap25 Snap23 GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 Gng11 ANIA_08769 Gng12 AgaP_AGAP008039 SNAP25 gngt2a KCNK9 snap-29 SNAP23 stx3b SLC6A4 1276578 1276579 git5 GNGT2 1276572 STE4 Adcy2 Adcy7 Syb SNAP29 Slc6a4 sfaD SNAP33 1276580 Vamp1 Prkaca Prkacb SNAP30 Vamp3 Vamp2 DAPPUDRAFT_319998 SS1G_03482 Htr1d Htr1f gnb5b GB1 Gnai2 prkacaa gnb5a VAMP1 Gnai1 Htr1b Htr1a VAMP2 Gnai3 VAMP3 prkacab snb-1 CND03830 syb1 ric-4 GNAI3 vamp2 CiGi1 ADCY2 PRKX SNC2 ADCY7 LmPKAC2b GNAI1 GNAI2 SNC1 Kcnk3 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 Gng7 snap25a GNG8 snap25b Gng8 STX3 Stx3 AgaP_AGAP004940 gnb-1 gng2 Gbeta5 gng3 Prkar2a gng5 Prkar2b gng7 5HT2 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04374 5HT2 type receptor mediated signaling pathway aPKC egl-8 HTR2A plcg1 Plcb2 SLC6A4 Plcb1 prkci plc-2 plc-3 1276578 plc-4 1276579 git5 GNGT2 PLCZ1 STE4 prkcb plc-1 Htr2a Htr2c Htr2b AgaP_AGAP009115 SLC18A1 Slc6a4 SLC18A2 Os07g0694000 sfaD 1276580 SS1G_03482 PLCB3 PLCB4 gnb5b GB1 gnb5a PLCB1 PLCB2 Gna11 prkchb CND03830 Gna14 pll-1 Pkc98E Plcd1 Plcd4 Plcd3 GNA14 Kcnk3 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Plcl2 Gng5 Plcl1 GNG4 Gng4 GNG7 GNA11 inaC Gng7 5-HT1A Gng8 GNG8 5-HT1B gnb-1 gng2 Gbeta5 gng3 gng5 PLCL1 plc PLCL2 gng7 NCU02175 Plce1 Kcnk9 gnb3b gnb3a gpbA 1274624 1275316 PLCD3 PLCD4 PLCD1 KCNK3 5-HT2A gng12a gnb1 gnb2 prkcbb prkcba AgaP_AGAP002748 Slc18a2 PLCE1 DICPUDRAFT_93216 Slc18a1 Plc21C plc1 norpA PRKCG gpb-2 PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD Plcg1 Pkcdelta PRKCA Pkc53E Prkcq Plcg2 pkc-1 pkc-2 Prkcg Prkch Gbeta13F gnb1b pkc-3 Prkci Prkcb Prkcd egl-30 Prkce PRKCQ Prkca prkcda gngt1 Gng10 Plch1 PRKCZ plcd1b Gbeta76C GNG10 8035476 Gnaq Ggamma1 gna11b BRAFLDRAFT_220697 PLCG2 1281188 sl cat-1 PLCG1 Galphaq Prkcz kcnk3a tpa-1 gpc-1 Gngt2 Vmat gnaq Plcz1 PLC4 PLC3 GPR5HT1B PLC5 GNG12 GNG11 PLC2 PLC1 PLC8 PLC7 GNB2 Gnb2 GNAQ AgaP_AGAP012252 GNB1 Gnb1 PLC9 GNB4 Gnb4 GNB3 Gnb3 GNB5 Gnb5 Gng11 Gng12 ser-1 Plcb4 Plcb3 Gnaq1 gngt2a KCNK9 HTR2B HTR2C 5HT3 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04375 5HT3 type receptor mediated signaling pathway VAMP3 snb-1 syb1 ric-4 vamp8 vamp2 SNC2 SNC1 Kcnk3 snap25a snap25b cat-1 STX3 Stx3 nSyb SNAP-25 kcnk3a Vmat Kcnk9 Snap29 Snap24 Snap25 Snap23 1274624 ANIA_08769 aex-4 KCNK3 SNAP25 KCNK9 snap-29 SNAP23 stx3b SLC6A4 Slc18a2 Slc18a1 Syb SLC18A1 SNAP29 Slc6a4 SLC18A2 Vamp8 SNAP33 Vamp1 SNAP30 Vamp3 Vamp2 VAMP8 VAMP1 VAMP2 5HT4 TYPE RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04376 5HT4 type receptor mediated signaling pathway gnb1 gnb2 HTR4 Htr4 LOC694289 Slc18a2 DICPUDRAFT_93216 Slc18a1 gpb-2 gpb-1 Gbeta13F gnb1b 1277119 Gng10 Galphaf Gbeta76C GNG10 Gnal 8035476 BRAFLDRAFT_220697 Gnas cat-1 Galphas nSyb kcnk3a SNAP-25 Vmat Gngt2 gnal GNG12 Snap29 Snap24 GNAL Snap25 Snap23 GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 gngt2a KCNK9 snap-29 SNAP23 stx3b SLC6A4 1276578 1276579 git5 GNGT2 STE4 Adcy2 Adcy7 Syb SLC18A1 SNAP29 Slc6a4 SLC18A2 Vamp8 sfaD SNAP33 1276580 Vamp1 SNAP30 Vamp3 Vamp2 SS1G_03482 VAMP8 gnb5b GB1 gsa-1 gnb5a VAMP1 VAMP2 VAMP3 snb-1 CND03830 syb1 ric-4 vamp8 vamp2 ADCY2 SNC2 ADCY7 SNC1 Kcnk3 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 Gng7 snap25a GNG8 snap25b Gng8 Stx3 STX3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 Kcnk9 gnb3b gnb3a gpbA 1274624 aex-4 KCNK3 5-HYDROXYTRYPTAMINE BIOSYNTHESIS%PANTHER PATHWAY%P04371 5-Hydroxytryptamine biosynthesis TPH2 Os10g0400500 Tph2 TPH1 DDC Ddc Tph1 TYDC TYRDC tdc-1 tph-1 bas-1 tph1b tph1a Trh tph2 LOC_Os10g23900 amd basl-1 hdl-1 5-HYDROXYTRYPTAMINE DEGREDATION%PANTHER PATHWAY%P04372 5-Hydroxytryptamine degredation PA0219 gll1504 ywdH RB10172 MAPKAPK5 SPAC922.07c ALDH7A1 AgaP_AGAP009944 MAOB MAOA ALDH1a ALDH3B2 SCO4780 SPBC21C3.15c SCO6441 ALDH3B1 mao MSC7 ALDH7B4 Aldh3b1 Aldh7A1 yfmT NCU03348 SCO6793 PA3504 DDB_G0276821 gbsA DR_A0274 aofH PA5312 alh-9 Aldh3a2 Aldh3a1 alh-1 Aldh7a1 Rv0458 alh-3 alh-2 alh-5 SCO4913 alh-4 alh-6 ALDH6 ALDH2B4 NCU03415 AgaP_AGAP009591 ALDH2 CT19744 ALDH2B7 PA4189 gucD Maoa Maob Aldh16a1 aldh1a2 aldh2 NCU07442 SCO5679 NCU00378 ALDH1A3 Aldh2b 1274323 SCO3420 Aldh2a ALDH1A2 Aldh1l1 ALDH1A1 Aldh1l2 dhaS Os09g0440300 ylo-1 FN0454 ALDH9A1 P5CDh1 ALD5 ALD6 Aldh4a1 ALD3 ALD4 Aldh2 ALD2 Aldh8a1 HFD1 ALDH3F1 aldH1 SCO5666 aldY aldH6 Il4i1 Lao1 ALDH1B1 EHI_042140 SPAC9E9.09c exaC Aldh1b1 aldh8a1 aldH aldB aldA Os01g0591300 alh-10 NCU02056 aldh4a1 SCO5657 slr0782 ALDH4A1 aldX Dmel\CG8665 SCO3486 alh-11 NCU09648 ALDH16A1 PA4073 yobN ALDH8A1 betB ALDH1L1 Aldh1a2 Aldh1a1 Aldh1a3 aldh3a2a puuC Aldh1a7 aldh3b1 Aldh9a1 ALDH1L2 Aldh IL4I1 SCO7436 SCO1174 ACAD10 glr3848 PA4022 aldh2.2 aldh2.1 aldh7a1 SCO4828 ALDH22A1 putA ALDH3I1 aldh3a2 UMAG_02508 feaB ALDH3A2 ALDH3A1 1274242 patD ACETATE UTILIZATION%PANTHER PATHWAY%P02722 Acetate utilization ACSS3 ACSS2 acs-19 BT_3692 Acss1 TM_1755 acs SPCC191.02c 1281701 PAE2474 Acss2 acsA-9 Acss3 acsA-7 acsA-8 FN1172 facA acsA-6 L7836.01 yqiS pta ACSS1 prpE acsA-10 acsA1 acsA2 BT_2551 DR_0460 1277153 LMJF_23_0540 acs2 acs1 PAE2481 eutD ACS ackA PAE2865 PA3568 acsA AcCoAS ACS1 acu-5 ACS2 ACTIVINBETASIGNALING_PATHWAY%PANTHER PATHWAY%P06210 Activinbetasignaling_pathway Med put alph Fur1 Mad babo Smox Actbeta Sara Smurf ADENINE AND HYPOXANTHINE SALVAGE PATHWAY%PANTHER PATHWAY%P02723 Adenine and hypoxanthine salvage pathway Pnp AAH1 PA0148 T19B4.3 adah-1 hprT acer-1 add2 add1 Tb10.70.6540 FN0288 add SPBC1683.02 apt DR_A0178 gad-3 HGPRT Hprt1 APRT hxA Adal pnp 1274840 hprt-1 HPRT1 PF3D7_1012400 CG16760 PRTFDC1 Tb10.70.6650 aah1 PA4645 Pnp2 ry hprt1 Aprt SCO3405 APT5 TM_0206 APT3 APT4 APT1 TM_1737 APT2 1276396 XRPT XDH Xdh HGPT SPAC1805.16c xdh-1 SCO4644 punA hpt CBG14916 SCO2546 SCO5662 Prtfdc1 SCO4972 DR_1376 PNP1 XDH1 xpt ADA xdhB XDH2 Ada SCO4917 apt1 GL50803_00112885 TM_1596 pnp-1 LOC510369 BT_4386 CELE_F15E6.6 PNP ADRENALINE AND NORADRENALINE BIOSYNTHESIS%PANTHER PATHWAY%P00001 Adrenaline and noradrenaline biosynthesis Dmel\CG10804 DBH Dbh SLC6A2 SLC6A3 Inmt slc6a19a.1 Th Tdc2 LOC_Os10g23900 Tbh Slc6a2 Syb SLC18A1 SNAP29 SLC18A2 Slc6a3 Maoa Nnmt Maob SNAP33 Vamp1 SNAP30 Vamp3 INMT Stx12 1276226 VAMP1 SYBL2 VAMP2 VAMP3 STX12 Ddc DDC syb1 ric-4 vamp2 SNC2 SNC1 SYP23 SYP22 SYP21 Dmel\CG43066 SYP24 PPP1R8 snap25a slc6a19b snap25b PEP12 ddc Syx7 ple anmt-3 aex-4 anmt-2 anmt-1 PNMT stx7l COMT Slc6a20 Comt stx12 Slc18a2 Slc18a1 Slc6a19 Slc6a18 SLC6A19 SLC6A18 SLC6A17 Slc6a15 SLC6A16 SLC6A15 Slc6a17 STX7 Stx7 bas-1 Vti1b sybA th2 NNMT MAOB MAOA SLC6A20 AgaP_AGAP009091 zgc:64002 mao cat-1 cat-2 SNAP-25 VTI1B Vmat Pnmt TYRDC AgaP_AGAP011279 Snap29 Os01g0254900 syx-7 Snap24 Snap25 TH Slc6a20a Slc6a20b hdl-1 SNAP25 snap-29 SNAP23 ALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02724 Alanine biosynthesis BCAT4 NCU04292 BAT1 BCAT7 ilvE bcat-1 BAT2 BCAT6 Dmel\CG1673 ilvK Bcat1 Bcat2 Os05g0558400 1272265 CELE_Y44A6D.5 ilvE2 BCAT1 DR_1626 BCAT3 BCAT2 ALLANTOIN DEGRADATION%PANTHER PATHWAY%P02725 Allantoin degradation ALN garK Dmel\CG6106 SPAC1F7.09c glxK garR allB allA allD allc glxR SCO6201 gcl SCO2145 alc-1 1272022 alc DAL3 ALLC DAL2 Allc DAL1 SPAC19G12.04 ALP23B_SIGNALING_PATHWAY%PANTHER PATHWAY%P06209 ALP23B_signaling_pathway Med put alph Fur1 Mad babo Smox Sara Smurf daw ALPHA ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00002 Alpha adrenergic receptor signaling pathway Plcb4 SNAP25 Plcb3 Adra2b SNAP23 egl-8 ADRA1B ADRA1A Plcb2 Plcb1 plc-2 plc-1 PLCE1 itpr1 AgaP_AGAP009115 Syb Plc21C PRKCG norpA Adra1b Adra1a Adra1d PRKCE PRKCD PRKCA Vamp1 ADRA2C Vamp3 ADRA2B Vamp2 ADRA2A Prkcg PLCB3 PLCB4 Prkcd Prkce VAMP1 Prkca PLCB1 PLCB2 VAMP2 VAMP3 Gna11 snb-1 syb1 ric-4 ITPR1 STX10 SNC1 GNA11 gna11b STX6 1281188 Stx6 snap25a snap25b nSyb SNAP-25 SYP61 Plce1 SYP6 Snap24 Snap25 ANIA_08769 Itpr1 ALZHEIMER DISEASE-AMYLOID SECRETASE PATHWAY%PANTHER PATHWAY%P00003 Alzheimer disease-amyloid secretase pathway App APP UMAG_03305 MPK4 MPK5 MPK6 MPK7 MPK1 MPK2 MPK3 KAT5 Kat5 MPK8 MPK9 p38b p38a PRKCG PRKCI PRKCH Kul PRKCB PRKCE pen-2 PRKCD mpkB PRKCA Pkc53E Prkcq Prkcg Prkch Prkci Prkcb Prkcd Prkce psenen PRKCQ Prkca bsk furin Ncstn mapk14a WNK8 PRKCZ klc-1 APH1A klc-2 kuz NCSTN APH1B mapk14b Prkcz Ca-alpha1D SS1G_05445 pck1 pck2 pmk-2 pmk-1 spk1 AgaP_AGAP012252 WNK2 CHRFAM7A LOC100027128 PCSK2 PCSK1 At2g31440 Apbb1 PCSK7 erkB PCSK6 Adam17 PCSK4 1279680 egl-3 prkci prkcb Adam10 Bace1 PSENEN nAChRalpha5 Psn nAChRalpha6 BACE1 BACE2 Psenen cacna1c PKN3 NCU06544 bli-4 adam10 APBB1 Cacnb1 Cacnb2 1279231 Apba1 Apba2 Apba3 aph-2 aph-1 mpk-1 Pkn2 PKN2 APBA1 Pkn1 PKN1 APBA3 APBA2 egl-19 1277857 AgaP_AGAP009207 Mapk9 CHRM2 CHRM3 Mapk7 Cacna1f CHRM1 Klc Mapk8 Cacna1c Cacna1d CHRM4 CHRM5 Mapk1 Mapk6 Mapk3 Fur2 Mapk4 Fur1 mak-2 Cacna1s AgaP_AGAP002748 LMPK Tb10.6k15.2790 MPK20 amon ADAM10 pkc-1 CACNB1 CACNB2 ADAM17 pkc-3 SS1G_11866 CEK1 Psen1 ADAM9 PF3D7_1113900 Psen2 Nct MPK10 CHRNA7 1269379 PSEN2 MPK13 CHRNA8 MPK14 CACNA1D MPK11 PSEN1 CACNA1C CACNA1F KLC1 BRAFLDRAFT_121298 Klc1 MPK18 MPK15 MPK16 acr-11 Chrm1 KLC4 Klc4 KLC3 Chrm3 MPK19 Klc3 KLC2 Chrm2 Klc2 Chrm5 Chrm4 krp1 CACNA1S tpa-1 mapk10 At3g52640/At3g52650 FUS3 Pcsk1 Pcsk2 cacna1sb Chrna7 Pcsk7 mapk12 Pcsk5 Pcsk6 Pcsk4 jnk-1 KSS1 CrMPK2 sel-12 aph1b aph1a mapk8 psen1 psen2 Adam9 mapk3 PKC1 mapk1 acr-16 Pkn acr-9 Aph1a Aph1b Aph1c FURIN mapk-15 MAPK9 MAPK8 MAPK7 inaC MAPK1 Furin kpc-1 MAPK6 MAPK4 MAPK3 Mapk12 Mapk13 Mapk14 Mapk15 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 MAPK11 SNOG_03299 Mapk10 Mapk11 ALZHEIMER DISEASE-PRESENILIN PATHWAY%PANTHER PATHWAY%P00004 Alzheimer disease-presenilin pathway WNT10B WNT10A FZD3 Fzd3 FZD2 Fzd2 JUP Jup Fzd5 FZD5 FZD4 Fzd4 FZD7 Fzd7 Fzd6 FZD6 FZD9 Fzd9 FZD8 Fzd8 Rbpj ACT Act Os12g0163700 BRAFLDRAFT_113720 DICPUDRAFT_46519 Mmp23 Mmp24 Mmp25 MMP21 MMP20 fzd9b MMP25 MMP24 act MMP27 TRIM2 TRIM3 MMP28 Tb09.211.0620 Wnt9a Wnt9b Mmp20 Bace1 Mmp21 Mmp12 Mmp13 Mmp14 Mmp15 Mmp16 Mmp17 WNT9B Mmp19 lag-1 BRAFLDRAFT_125401 WNT9A BACE1 MMP12 BACE2 Psenen MMP14 actin shg MMP13 MMP16 MMP15 MMP17 MMP19 Wnt8b Wnt8a LOC100029767 Act57B PGTG_05488 cdh1 TRIADDRAFT_49626 WNT8C WNT8A WNT8B Os05g0106600 trpl fzd7a fzd7b FSTL1 fz UMAG_11232 Wnt7b egl-20 Wnt7a At1g08700 ASK7 ASK8 ASK5 ASK3 Trim3 ASK4 Trim2 WNT7B ASK1 ASK2 PFL2215w zmp-2 BRAFLDRAFT_56711 WNT7A fzd8b fzd8a CYIIIB CYIIIA BRAFLDRAFT_114976 aph-2 aph-1 DICPUDRAFT_90232 1277857 v1g188243 GPRFZ2 TVAG_337240 Ctnnb1 Cdh3 CDH3 PHYPA_005833 CDH1 Cdh1 LOC100176797 acnA 37852 v1g169611 BRAFLDRAFT_58093 ASK9 v1g234494 wnt4a SNOG_01139 RIM11 actg1 Nct NOTCH2 NOTCH3 NOTCH1 LOC100185123 NOTCH4 BRAFLDRAFT_121298 BRAFLDRAFT_116948 Dvl1 DVL1 Dvl2 DVL2 Dvl3 DVL3 krp1 Act5C Pcsk1 Pcsk2 BRAFLDRAFT_114535 CiGSK Pcsk7 Pcsk5 Pcsk6 Pcsk4 Su(H) CBG02167 acta2 v1g242065 BRAFLDRAFT_126324 sel-12 CBG02162 CBG02161 ACT1B Trpc6 ACT1A Trpc5 Trpc7 Trpc2 Trpc1 IscW_ISCW024111 Trpc4 Trpc3 ACT1C wnt11 TRPC7 ACT12 ACTR2 TRPC5 TRPC6 TRPC3 psen1 TRPC4 TRPC1 psen2 wnt7aa trp TVAG_054030 ACTBL2 At2g29900 Os01g0252100 BRAFLDRAFT_115565 BRAFLDRAFT_115566 LOC100028958 RBPJL Aph1a Aph1b Lrp1 Aph1c LRP1 actc2 actc1 4576288 LRP5 Lrp6 LRP4 FURIN act9 LRP3 LRP2 act3 Lrp2 Lrp3 Lrp4 LRP6 Lrp5 wnt10a Rbpjl actba actbb Furin AgaP_AGAP009731 AgaP_AGAP009734 fz3 fz2 Act1 ACT1 cbf11 LOC100016601 cbf12 ACT2A act1 fzd10 NECTIN1 App APP BRAFLDRAFT_104698 Nectin1 ACTB KAT5 Kat5 ACT9 KAT7 Kat7 Act7 ACT7 Wnt10a Act5 ACT4 ACT5 ACT2 Wnt10b ACT3 EHI_107290 pen-2 Actb Actr2 psenen GL50803_0040817 actb TRIADDRAFT_63375 hop-1 ctnnb1 ctnnb2 IDA5 APH1A APH1B arm LOC100092493 TVAG_512800 gsk31 PCSK2 PCSK1 At2g31440 tcf7l1a Apbb1 PCSK7 Apbb2 Adam17 PCSK6 Apbb3 PCSK4 egl-3 LOC_Os10g37740 BRAFLDRAFT_118309 BRAFLDRAFT_127490 PSENEN wnt8a wnt8b Psn MMP23B CD44 wnt5b wg bli-4 LOC100073534 APBB2 APBB1 APBB3 Cd44 PHYPA_016713 1279231 BRAFLDRAFT_127489 CNA04650 BRAFLDRAFT_127488 CTNNB1 At3g11870 PF14_0124 PHYPA_016711 rbpja gsk-3 Act88F actc1b actc1a Fur2 ACTG2 ACTG1 Fur1 tcf7l1 gskA Wnt5a Os05g0438800 Wnt5b WNT5B gsk3 HAC1 amon WNT5A ERN1 Ern2 Ern1 ERN2 ADAM17 Psen1 Psen2 Lrp1b Act42A BRAFLDRAFT_115291 1269379 IRE1B TCF7 IRE1A PSEN2 PSEN1 Wnt6 WNT6 mmp2 Wnt5 BRAFLDRAFT_60743 v1g210933 Wnt3a IRE1 TRIADDRAFT_56111 WNT1 Wnt2 WNT2 Wnt1 WNT3 Wnt4 Actg1 Wnt3 Actg2 WNT4 wnt3 wnt2 wnt1 ire1 WNT3A gskt At3g52640/At3g52650 BRAFLDRAFT_94959 LRP1B wnt5 Wnt2b AFDN Act79B GSK3B GSK3A WNT2B WBGene00275837 acta1b dvl3a Afdn BRAFLDRAFT_271417 actr2 actr2a aph1b aph1a Arp53D MMP7 Mmp7 MMP1 MMP2 Mmp2 WNT16 Mmp8 MMP8 Mmp9 MMP9 ACTA2 acta1a Notch4 Gsk3b ACTA1 act10 Notch1 1281498 Notch2 Notch3 LOC100020439 act18 Wnt16 actr2b Wnt11 Lef1 arx-2 LEF1 spe-4 trpc7b WNT11 ERBB4 act23 BRAFLDRAFT_56698 act22 kpc-1 WBGene00098673 TCF7L2 Actc1 TCF7L1 Actbl2 Act87E ACTC1 lef1 BRAFLDRAFT_56687 Erbb4 FZD10 RBPJ Os01g0296100 fzd2 fzd4 fzd5 fzd7 gsk3ba Fzd10 gsk3bb Acta1 Acta2 SS1G_08733 BRAFLDRAFT_114958 act-2 act-1 Trpgamma cwn-2 DICPUDRAFT_48914 furin act-4 act-3 act-5 BRAFLDRAFT_79607 Ncstn TVAG_090470 BRAFLDRAFT_118160 N wnt7bb trp-2 NCSTN prk-1 Tcf7l1 Tcf7l2 FZD1 Fzd1 AMINOBUTYRATE DEGRADATION%PANTHER PATHWAY%P02726 Aminobutyrate degradation gta-1 PAE1799 gabT 1270119 puuE UGA1 GATA ABAT Abat Gabat SCO5676 uga1 davT gabT-2 gatA ANANDAMIDE_DEGRADATION%PANTHER PATHWAY%P05728 Anandamide_degradation FAAH Faah LOC708660 ANDROGEN ESTROGENE PROGESTERONE BIOSYNTHESIS%PANTHER PATHWAY%P02727 Androgen estrogene progesterone biosynthesis Hsd17b2 Hsd17b7 PF3D7_0322300 Hsd17b6 Soat2 Soat1 HSD17B3 Lipa HSD17B6 HSD17B7 LIPA CYP19A1 Cyp19a1 Hsd3b6 Hsd3b5 Hsd3b4 SOAT1 Hsd3b3 HSD3B Hsd3b2 SOAT2 HSD17B1 HSD17B2 Hsd17b1 ANGIOGENESIS%PANTHER PATHWAY%P00005 Angiogenesis Prkd3 ARAF Nr1i2 Prkd1 Prkd2 RBPJ akt2l LOC100177240 vps-34 akt3b fzd2 fzd5 AKT2 Akt3 Akt2 AKT3 Akt1 AKT1 gsk3ba gsk3bb PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD Plcg1 Araf FRS2 Frs2 PRKCA Pkc53E Prkcq Plcg2 FRS3 ephb3 Frs3 Prkcg Prkch Prkci Prkcb PRKD3 cwn-2 Arhgap1 Prkcd Prkce Axin1 PRKCQ PRKD2 Axin2 PRKD1 Prkca Arhgap8 Ser Pdgfc Pdgfd BRAFLDRAFT_118160 mapk14a PDGFB PDGFA HIF1A PRKCZ N wnt7bb paxB Hif1a PDGFD PDGFC PLCG2 Pdgfa mapk14b Pdgfb PLCG1 Prkcz 4930544G11Rik Tcf7l2 FZD1 JAG2 Fzd1 Jag2 WNT10B WNT10A FZD3 Fzd3 JUN Jun Jag1 JAG1 FZD2 Fzd2 Fzd5 FZD5 grb2a grb2b Pik3c2b BRAF Pik3c2a Pik3c2g Rbpj Fgfr1 BRAFLDRAFT_113720 YALI0_E23001g ARHGAP8 TGFB1I1 Pax ARHGAP1 Braf Cryab ptgfr Cryaa f7 rasD rasG rasS Jak1 JAK1 angpt2b APC2 Apc2 SPHK2 SPHK1 Dl dsh-2 lag-1 rasC FOS rasB Fos rhoad jak1 rhoab F3 rhoaa AgaP_AGAP010687 F7 CiDsh CRYAA Pik3r1 CRYAB Pik3r2 Pik3r3 birc5.1 pikB frzb nras pikC ced-2 NR1I2 pikE hrasb C901 hrasa NRAS fz AgaP_AGAP011890 FRZB Wnt7b dla Wnt7a dlc pikA dlb dld STAT1 WNT7B STAT3 WNT7A fzd8b cRhoA cRhoB Stat3 Stat1 LOC685590 AgaP_AGAP009207 1269955 efnb1 1269953 rga-1 Grb14 Ctnnb1 Fgf2 FGF1 FGF2 Fgf1 1277104 GRB14 Src64B MAP2K4 MAP2K1 MAP2K2 akt-2 F2R akt-1 Map3k1 Nras pla2g4a MAPKAPK3 DAPPUDRAFT_301996 Frzb MAPKAPK2 NOTCH2 SHC2 NOTCH1 Shc1 SHC1 NOTCH4 F2r Pdgfrb Pdgfra Dvl1 DVL1 angpt1 Dvl2 DVL2 cryaba Dvl3 DVL3 kdrl v1g247341 stat1a efnb2a efnb2b PTPRB Sos lin-45 CiGSK Su(H) FLT4 PIK3CD RSA-14-44 PIK3CB PIK3C2A PIK3CG Birc5 PIK3C2B tie2 NCK2 Nck2 axin2 axin1 drk NCK1 Nck1 mapk8 ANG2 nck1 PKD mapk3 wnt7aa mapk1 Epha3 PIK3CA dsh BIRC5 PIK3C3 SOS1 let-60 Sos2 CRK SOS2 Sos1 Crk RBPJL Src SRC sem-5 gefA gefB Ephb1 Ephb2 Ephb3 wnt10a Rbpjl 1276231 1276232 AgaP_AGAP009731 crk AgaP_AGAP009734 fz3 Mapk14 ANGPT2 piki-1 pdgfaa ANGPT1 gm2a pik3ca pak-1 AgaP_AGAP010940 APC Apc CRKL Crkl LOC395991 KDR Kdr Wnt10a EPHB2 EPHB1 Wnt10b EPHB3 gefY cryaa rho-1 SFRP1 gefR bsk ptk2ab EPHA3 crkl Grb7 GRB7 Rasa1 ctnnb1 SH2D2A ctnnb2 PIK3R3 PIK3R2 Pi3K92E PIK3R1 1281346 sl Grap arm rhoA RHO1 Rho1 jag1b jag1a AgaP_AGAP011036 rho5 pxl-1 rho1 Ptk2 PTK2 AgaP_AGAP012252 Grb2 GRAP jag2b Pla2g4c Pla2g4a Rhoc Pik3c3 Rhoa Rhob prkci prkcb HRAS Sfrp1 PDGF-A MAPk-Ak2 RHOC RHOA RHOB 1269341 rhob wnt5b DAPPUDRAFT_301818 wg PAK1 Pak1 stat3 zgc:101699 Vegfa Pak3 PAK3 Pak2 PAK2 MAP3K1 kin-32 pak2 VEGFA Map2k4 Map2k2 Map2k1 Tgfb1i1 CTNNB1 Hras mig-5 rbpja Mapk8 gsk-3 Mapk1 Ets1 Mapk6 ETS1 Mapk3 mak-2 gskA Wnt5a AgaP_AGAP002748 Wnt5b dkf-2 Ras85D YALI0_D01045g 1269396 PDGFRB PDGFRA Sh2d2a ets1 WNT5B WNT5A pkc-1 Dok1 DOK1 Dok2 DOK2 pkc-3 Dok3 DOK3 Sphk2 Sphk1 RAF1 Raf1 TCF7 PXN Pxn PLD1 Pld1 PLD2 Pld2 EFNB2 EFNB1 Wnt5 Hspb1 Pik3cg LPXN Hspb2 AgaP_AGAP009499 WNT1 Wnt2 Pik3cb WNT2 Wnt1 tpa-1 Pik3cd CG17401 Efnb1 Efnb2 wnt2 wnt1 Pik3ca age-1 gskt wnt5 Wnt2b vegfaa RhoGAP68F FGFR1 PRR5 limB GSK3B GSK3A WNT2B Prr5 HSPB2 HSPB1 map2k4a CASP9 dvl3a plc-3 Angpt1 Angpt2 PLA2G4D PLA2G4B PLA2G4C AXIN1 PLA2G4A AXIN2 Notch4 Gsk3b fgfr1a Notch1 RASA1 Notch2 fosab AgaP_AGAP000018 Lpxn Pi3K68D TRIADDRAFT_20369 akt2 DLL1 Dll1 DLL3 Dll3 Dll4 pld-1 DLL4 MAPK8 inaC MAPK1 v1g243859 MAPK6 MAPK3 Mapkapk3 TCF7L2 SS1G_03867 Pi3K21B Mapkapk2 Casp9 Nos3 NOS3 kras MAPK14 Dlk1 DLK1 MAPK10 AgaP_AGAP010273 Raf KRAS TEK Tek ANGIOTENSIN_II-STIMULATED_SIGNALING_THROUGH_G_PROTEINS_AND_BETA-ARRESTIN%PANTHER PATHWAY%P05911 Angiotensin_II-stimulated_signaling_through_G_proteins_and_beta-arrestin Plcb2 Rhoa egr1 Mapk3 Plcb1 GNGT2 MAP2K1 MAP2K2 Agtr1 PRKCA SIRT6 rhoad rhoab RHOA PLCB3 gnb1b AGTR1 Prkca Adrbk2 PLCB1 Raf1 RAF1 arrb1 PLCB2 Gng10 ITPR1 ITPR2 ITPR3 GNG3 GNG10 GRK3 Gng3 GRK2 Grk2 GRK5 Grk5 Gng4 GNG4 GNG7 Gng7 Gnaq GRK6 Grk6 Arrb2 Agtr1a GNG8 MAPK1 Arrb1 Agtr1b Gng8 MAPK3 EGR1 Egr1 Gngt2 gng3 grk3 gnaq GNG11 AGT Agt Map2k2 Map2k1 GNB2 Gnb2 GNAQ GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 Gng11 Itpr3 Itpr2 Itpr1 Plcb3 gnb1 gnb2 Mapk1 ARRB1 ARRB2 Elk1 ELK1 APOPTOSIS SIGNALING PATHWAY%PANTHER PATHWAY%P00006 Apoptosis signaling pathway GZMH Hsp70Bbb Chuk casp8 Mapk10 LOC745166 MPK4 MPK5 MPK6 Hsp68 MPK7 MPK1 MPK2 MPK3 Os01g0840100 TNFSF10 CC-1 AgaP_AGAP011190 Tp53 EIF2A LOC100360940 Os01g0885000 mpkB tp53 5667763 Apaf1 bsk TP53 Pi3K92E HSP70A SSA3 SSA4 SSA1 Cradd SSA2 FADD CRADD ssa1 ssa2 hsps-1 Diablo 5667627 Faslg HSP70-1 HSP70-5 HSP70-4 HSP70-3 CYC Bcl2l11 Bcl2l10 hspa8 hspa5 prkcb hsp70_4 MAP4K2 Bcl2l1 Bcl2l2 CYTC-1 Fadd Hspa1b Hspa1a XIAP SUI2 Map2k7 RELA RELB Hspa1l At2g40290 CBG13234 xiap MAP4K5 MAP4K3 MAP4K4 MAP3K1 Prkra Map2k4 Map2k3 PRKRA FAS Fas Mapk9 Mapk8 Mapk1 cyc1 Mapk3 mak-2 cycA 1269396 Xiap eIF2alpha Rela Relb pkc-1 At4g17580 DIABLO MPK10 baxa cycs MPK13 MPK14 MPK11 CYC7 Atf6b TBC1D13 Pik3cg RIPK1 CYC1 Pik3cb cyc-2.2 Igf2r tpa-1 Pik3cd cyc-2.1 HSPA8 Pik3ca HSPA5 mapk10 grp78 HSPA6 HSPA2 Ripk1 EIF2S1 IGF2R FUS3 NFKBIA Hspa8 Hspa5 CYCT CYCS Hspa2 1275756 CrMPK2 Tmbim6 map2k4a CASP9 CASP7 CASP8 CASP3 Creb1 Cycs Cyct Tnfsf10 dbo CREB1 LTA Lta fosab AgaP_AGAP000018 LTB Ltb ATF6B akt2 eif2A MAPK9 MAPK8 MAPK1 PHYPA_010689 MAPK3 Casp8 Casp7 Casp9 Casp3 birc2 MAPK10 eif2a tradd Bax BAX SNOG_03299 ATF1 Atf2 ATF2 Atf1 UMAG_03305 Eif2ak2 akt3b bcl2l2 bcl2l1 AKT2 Akt3 Akt2 AKT3 Akt1 bax AKT1 PRKCG DAXX PRKCH ENDOG PRKCB PRKCE PRKCD PRKCA Pkc53E Prkcq hspB Endog Prkcg Prkch BI-1 Prkcb Prkcd Prkce Tnfrsf10b PRKCQ ATF7 Prkca Atf7 Atf6 ATF6 ATF3 Atf4 ATF4 Atf3 eif-2alpha mcl1a tif211 EndoG Hsc70-4 PHYPA_010924 Hsc70-2 LOC_Os03g16860 Hsp70Ba LOC709412 Hsc70-3 Hsc70-1 JUN Jun bip1 hspa8b EIF2AK2 eif2s1a eif2s1b Nfkbia 1276444 1274027 BIP3 spk1 BIP2 BIP1 ITA Rel REL Os05g0460000 Daxx hsc70 Ikbkb LOC_Os11g47760 ptgfr Tnfrsf1b IKBKB Tnfrsf1a AIFM1 CASP10 Nfkb2 Nfkb1 hsp70.3 FOS Fos PHYPA_005007 cyc-1 JDP2 kgb-1 Jdp2 hsp-4 pikB hsp-3 pikC hsp-1 Aifm1 C49C3.10 BI1 LOC_Os03g60620 Tb11.01.3110 IAP3 pikA hsp-70 SNOG_15669 Cyt-c-p HSPA1L Bik BIK ANIA_02062 mpk-1 LOC685590 HSPA1B Cyt-c-d HSPA1A AgaP_AGAP009207 Map3k14 PHYPA_014428 TNF Tnf Map3k5 Madd AIF MAP3K5 MAP2K3 MAP2K4 PHYPA_014678 hppy akt-2 CELE_F44E5.4 akt-1 IKKbeta gck-2 Map3k1 SS1G_11866 MADD CEK1 PF3D7_0818900 CREM Map4k5 mcm5 Map4k4 Map4k3 BAG4 BCL2L10 BCL2L11 Bag4 Bag3 BAG3 Bag1 Crem BAG1 MAP2K7 Mcl1 MCL1 TNFRSF10C TNFRSF10B TNFRSF10A cytC NFKB1 NFKB2 TNFRSF10D Map4k2 Map4k1 DICPUDRAFT_49867 casp3a Bcl2 BCL2 MAP3K14 BCL2L2 BCL2L1 jnk-1 KSS1 TRADD Traf6 Birc3 Birc2 PIK3CD FASLG PIK3CB CELE_Y51B9A.9 HSP70-18 PIK3CG LMJF_28_2770 Tradd Traf2 BOK Bok CHUK mapk8 APAF1 mapk3 TRAF2 TNFRSF1B mapk1 TNFRSF1A PIK3CA TMBIM6 BIRC2 BIRC3 Hsp70Aa EHI_052860 Gzmb hsp70l WBGene00094756 KAR2 Bak1 Cflar BAK1 Eif2s1 pik3ca GZMB CFLAR ARGININE BIOSYNTHESIS%PANTHER PATHWAY%P02728 Arginine biosynthesis argB argE arg-12 arg-14 ASL2 pyrAB ASL1 BT_2085 arg7 arg6 pyr-1 CARB C44E12.1 At4g17830 AgaP_AGAP008141 1271961 ygeY argG argF arcB argI argH ARG4 CPA2 ARG2 ARG3 carB1 carB2 ARG1 CAD Cad GL50803_0010311 arg3 BT_3549 arg4 yodQ dapE LOC702037 carB At4g24830 URA2 Cps1 pyrABCN argx NCU02227 ASL Asl Nags Ass Argl TM_1666 SCO5139 At5g10920 ARG56 ASS1 Ass1 ylmB LA_2692 r arg-6 SCO5185 CPS1 DR_2025 SPCC757.05c arg11 NAGS ura1 arg12 OTC Otc ASCORBATE DEGRADATION%PANTHER PATHWAY%P02729 Ascorbate degradation CELE_F08F8.7 sgbE sgcE rpe RPE Rpe ulaF RPE1 At1g63290 At3g01850 SPAC31G5.05c alsE araD ASPARAGINE AND ASPARTATE BIOSYNTHESIS%PANTHER PATHWAY%P02730 Asparagine and aspartate biosynthesis asnA ASNS ASN3 SCO0386 ASN1 asnB MJ1116 PF3D7_0309500 asns-2 MJ1056 1271572 asns-1 asn1 Os06g0265000 asn asnH ASN2 Asns ATP SYNTHESIS%PANTHER PATHWAY%P02721 ATP synthesis ATP5F1B Atp5f1b ATPC mftD COX1 DAPPUDRAFT_309746 qoxB ATPsynbeta Cyc1 atpG v1g230667 Atp5f1c ATP5F1C ATPC1 AXON GUIDANCE MEDIATED BY NETRIN%PANTHER PATHWAY%P00009 Axon guidance mediated by netrin RHOU AgaP_AGAP000018 Pik3r1 Unc-115a Pik3r2 Pik3r3 Vasp NetA NetB Pi3K68D BRAFLDRAFT_122664 NTN4 PIK3R3 Ntn4 Pi3K92E PIK3R2 PIK3R1 Ntn1 NTN1 Ntn3 NTN3 PIK3R5 CDC42 ABLIM1 rac3a rac3b PLCG2 Pik3cg sl PLCG1 Pik3cb Pik3cd Cdc42 NTNG1 VASP NTNG2 Pik3ca age-1 NFATC3 pik3ca Pik3c2b NFATC2 Pik3c2a Pik3c2g NFATC4 max-1.2 8029221 Ntng1 Unc5b Unc5a Unc5d DAPPUDRAFT_306746 Unc5c LOC685590 ntn1a cRac1A cdc42 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B rac1a Enah rac1b Ci-NET1a RAC2 Rac2 Nfatc4 Rhou Rac1 RAC1 BRAFLDRAFT_126918 Nfatc3 Nfatc2 UNC5A DCC UNC5B Dcc max-1 rac1 Plcg1 UNC5C Plcg2 UNC5D ENAH PIK3CA unc-5 AXON GUIDANCE MEDIATED BY SEMAPHORINS%PANTHER PATHWAY%P00007 Axon guidance mediated by semaphorins Nrp1 NRP1 cRac1A DPYS Rhoa rac1a rac1b DPYSL4 DPYSL5 DPYSL2 RAC2 Rac2 Crmp1 Rac1 RAC1 rac1 rhoab RHOA Plxna1 nrp1 ARHGEF1 nrp1a SEMA3A Arhgef1 CRMP1 CRMP PAK1 Sema4d Pak1 rac3a rac3b PLXNA1 Fyn FYN Dpysl2 Dpysl4 Dpysl5 SEMA4D cdk5 Dpys dpysl3 Sema3a cRhoA Cdk5 CDK5 FES Fes fyna fynb PLXNB1 FRK AXON GUIDANCE MEDIATED BY SLIT ROBO%PANTHER PATHWAY%P00008 Axon guidance mediated by Slit Robo cRhoB DAPPUDRAFT_306746 ntn1a cRac1A cdc42 racE EHI_181250 cxcl12 Slit1 Slit2 Slit3 Rhoc ROBO1 rac1a rac1b Enah sax-3 Ci-NET1a EHI_197840 Rhoj Cxcr4 RAC2 Rac2 racA RAC3 Rac1 RAC1 racB BRAFLDRAFT_126918 Ptp10D DCC Dcc rac1 rho-1 RHOC RHOB rac1A Robo1 ENAH rac1B EHI_070730 DAPPUDRAFT_301996 RHOJ cxcr4 NetA NetB Cxcl12 BRAFLDRAFT_122664 TRIADDRAFT_20369 Rop3 NTN4 CXCR4 Ntn4 Ntn1 rac-2 NTN1 Ntn3 NTN3 CDC42 robo2 robo3 rac3a rac3b SLIT1 ABL1 Abl1 SLIT3 v1g243859 SLIT2 SRGAP1 rhoA robo1 RHO1 Rho1 Cdc42 NTNG1 NTNG2 SS1G_03867 RAC6 RAC5 slit3 cxcr4a slit2 rho5 cxcr4b rho1 rho4 8029221 CXCL12 Ntng1 B CELL ACTIVATION%PANTHER PATHWAY%P00010 B cell activation Ptpn6 hrasa MAPK9 NRAS MAPK8 rac3a rac3b MAPK1 cna-1 PHYPA_018206 MAPK3 Mapk12 MAP3K2 Mapk13 MAP3K3 Mapk14 pik3ca MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 Map2k2 Map2k1 cmd-1 LOC685590 PTPN6 Chuk Hras Mapk10 Frk Mapk11 Mapk9 cRac1A Mapk8 BRAFLDRAFT_124869 ARAF Mapk1 Mapk3 rac1a rac1b calA MAP2K1 MAP2K2 ATP6V1G2 PRKCB NFKBIL1 PRKCD Araf v1g239788 Plcg2 Map3k3 Map3k2 Nras Prkcb Prkcd BTK Btk RAF1 Raf1 Blk CALM Cd79a Cd79b ITPR1 Calm3 ITPR2 ITPR3 Calm1 CD79B CD79A LMJF_09_0910 CD19 calm3b PLCG2 Pik3cg Grap Pik3cb Pik3cd LYN Lyn Ptprc Ppp3ca Ppp3cc Jun JUN Ppp3cb Pik3ca mapk10 grb2a BRAF BRAFLDRAFT_59748 Nfkbia NFKBIA 11217 PTPRC PGTG_11337 BRAFLDRAFT_87235 CAM7 GRB2 Grb2 GRAP CALM1 CAM2 Itpr3 CD22 Itpr2 Itpr1 Ikbkb CAM1-3 TRIADDRAFT_37105 PIK3CD PIK3CB PIK3CG IKBKB PPP3CA PPP3CB prkcb BLNK Rac2 RAC2 Nfkbil1 Rac1 RAC1 HRAS Cd22 VAV3 Vav3 PHYPA_013668 UMAG_03910 SYK CHUK Syk rac1 SIRT6 FOS Fos Vav1 CAM VAV1 Cam VAV2 mapk1 Vav2 PIK3CA Blnk SOS1 Sos2 Sos1 SOS2 AgaP_AGAP010957 v1g88970 hrasb BETA1 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04377 Beta1 adrenergic receptor signaling pathway gnb1 gnb2 pkaC LOC694289 PRKACG DICPUDRAFT_93216 PRKACA Adrb1 PRKACB gpb-2 gpb-1 pkac1 Prkx Gbeta13F gnb1b LMJF_35_3960 Pka-R2 1277119 Pka-C1 Pka-C3 Gng10 Galphaf ADRB1 Gbeta76C GNG10 Gnal 8035476 PRKAR2B PRKAR2A BRAFLDRAFT_220697 prkacbb Gnas prkacba Galphas nSyb SNAP-25 kin-1 Gngt2 gnal GNG12 Snap29 Snap24 GNAL Snap25 Snap23 GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 GNAS Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 AgaP_AGAP008039 SNAP25 gngt2a snap-29 SNAP23 stx3b 1276578 1276579 git5 GNGT2 STE4 Adcy2 Adcy7 Syb SNAP29 Vamp8 sfaD SNAP33 1276580 Vamp1 Prkaca Prkacb SNAP30 Vamp3 Vamp2 DAPPUDRAFT_319998 SS1G_03482 VAMP8 gnb5b GB1 gsa-1 prkacaa gnb5a VAMP1 VAMP2 VAMP3 prkacab snb-1 CND03830 syb1 ric-4 vamp8 vamp2 ADCY2 PRKX SNC2 ADCY7 LmPKAC2b SNC1 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 1281784 Gng7 snap25a GNG8 snap25b Gng8 Stx3 STX3 AgaP_AGAP004940 gnb-1 gng2 Gbeta5 gng3 Prkar2a gng5 Prkar2b gng7 LOC112204126 gnb3b gnb3a 1281793 gpbA aex-4 BETA2 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04378 Beta2 adrenergic receptor signaling pathway kin-1 Gngt2 gnal GNG12 GNAL GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 GNAS Gnb3 GNB3 GNB5 Gnb5 Gng12 AgaP_AGAP008039 gngt2a 1276578 1276579 git5 GNGT2 STE4 Adcy2 Adcy7 sfaD 1276580 Prkaca Prkacb DAPPUDRAFT_319998 SS1G_03482 gnb5b GB1 gsa-1 prkacaa gnb5a prkacab CND03830 ADCY2 PRKX ADCY7 LmPKAC2b GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 Gng7 GNG8 Gng8 AgaP_AGAP004940 gnb-1 gng2 Gbeta5 gng3 Prkar2a gng5 Prkar2b gng7 LOC112204126 gnb3b gnb3a 1281793 gpbA gnb1 gnb2 pkaC LOC694289 PRKACG DICPUDRAFT_93216 PRKACA Adrb2 PRKACB gpb-2 gpb-1 pkac1 Prkx Gbeta13F gnb1b LMJF_35_3960 Pka-R2 1277119 Pka-C1 Pka-C3 Gng10 Galphaf ADRB2 Gbeta76C GNG10 Gnal 8035476 PRKAR2B PRKAR2A BRAFLDRAFT_220697 prkacbb Gnas prkacba Galphas BETA3 ADRENERGIC RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04379 Beta3 adrenergic receptor signaling pathway Gng10 Galphaf Gbeta76C GNG10 Gnal 8035476 BRAFLDRAFT_220697 Gnas Galphas nSyb SNAP-25 Gngt2 gnal GNG12 Snap29 Snap24 GNAL Snap25 Snap23 GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 GNAS Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 gngt2a snap-29 SNAP23 stx3b 1276578 1276579 git5 GNGT2 STE4 Adcy2 Adcy7 Syb SNAP29 Vamp8 sfaD SNAP33 1276580 Vamp1 SNAP30 Vamp3 Vamp2 SS1G_03482 VAMP8 ADRB3 gnb5b GB1 gsa-1 gnb5a VAMP1 VAMP2 VAMP3 snb-1 CND03830 syb1 ric-4 vamp8 vamp2 ADCY2 SNC2 ADCY7 SNC1 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 1281784 Gng7 snap25a GNG8 snap25b Gng8 STX3 Stx3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 gnb3b gnb3a gpbA aex-4 gnb1 gnb2 LOC694289 DICPUDRAFT_93216 gpb-2 gpb-1 Adrb3 Gbeta13F gnb1b 1277119 BIOTIN BIOSYNTHESIS%PANTHER PATHWAY%P02731 Biotin biosynthesis BIO2 SCO5890 SCO1243 bioA bio-1 yhxA BIOF bio2 TM_1269 RB3176 pylB BT_1443 bioK BT_0870 bioF bioD BT_1835 DR_2346 BIO4 bioB kbl BIO3 BLOOD COAGULATION%PANTHER PATHWAY%P00011 Blood coagulation KNG2 KNG1 Kng1 Proc Gp9 Serpind1 F13b F10 SERPIND1 F12 F11 Plat Serpina10 GP5 Thbd GP9 PROC Plau Pros1 Serpinc1 F13B A2m KLKB1 F2rl2 F2RL3 F2rl3 App APP SERPINA1 PROS1 ITGB3 Pzp SERPINA10 ITGA2B SERPINE1 F13A1 PLAT THBD f7 Gp1bb PLAU Serpinf2 Gp1ba Serpinb2 Procr FGB Fgb FGA Fga SERPINB2 VWF GP1BB SERPINF2 F2R FGG PLAUR F13a1 GP1BA Proz F2 Tfpi F3 F5 F7 Itga2b PROCR F8 F9 Itgb3 Serpine1 Plaur Serpina1 serpinc1 SERPINC1 F2r PROZ PLG Klkb1 Plg TFPI Gp5 BMP_SIGNALING_PATHWAY-DROSOPHILA%PANTHER PATHWAY%P06211 BMP_signaling_pathway-drosophila Med tld put alph Fur1 Mad nej Actbeta daw Pdp babo myo wit Smox dpp gbb scw tsg sog Smurf sax BUPROPION_DEGRADATION%PANTHER PATHWAY%P05729 Bupropion_degradation CYP2B6 CADHERIN SIGNALING PATHWAY%PANTHER PATHWAY%P00012 Cadherin signaling pathway DAPPUDRAFT_223674 CSNK2A1 Cad89D CSNK2A3 CSNK2A2 SS1G_08733 BRAFLDRAFT_114958 act-2 act-1 cwn-1 cwn-2 DICPUDRAFT_48914 kug act-4 act-3 DAPPUDRAFT_305830 act-5 BRAFLDRAFT_79607 TVAG_090470 BRAFLDRAFT_118160 Cad74A wnt7bb PCDHA1 PCDHA5 PCDHA4 PCDHA3 PCDHA2 Tcf7l1 PCDHA9 PCDHA8 PCDHA7 Tcf7l2 PCDHA6 FZD1 LYN Lyn Fzd1 WNT10B WNT10A FZD3 Fzd3 FZD2 Fzd2 Cad99C Fzd5 FZD5 FZD4 Fzd4 FZD7 Fzd7 Fzd6 FZD6 FZD9 Fzd9 FZD8 Fzd8 Dchs1 Pcdh20 PCDHGA10 PCDHGA11 PCDHGA12 ACT Act PCDHB2 PCDHB1 fmi-1 FAT1 PCDHB6 Fat2 FAT2 PCDHB5 Fat1 Os12g0163700 FAT3 PCDHB4 DCHS1 BRAFLDRAFT_113720 DICPUDRAFT_46519 PCDHB3 Fat3 PCDHB9 PCDHB8 PCDHB7 Csnk2a2 Csnk2a1 ds fzd9b act Tb09.211.0620 Wnt9a Wnt9b lin-17 CK2B CK2A WNT9B BRAFLDRAFT_125401 WNT9A actin shg Wnt8b Wnt8a LOC100029767 Act57B PGTG_05488 cdh1 cdh2 TRIADDRAFT_49626 WNT8C WNT8A WNT8B Os05g0106600 fzd7a fzd7b FSTL1 EGFR ft fz UMAG_11232 Wnt7b egl-20 Wnt7a WNT7B PFL2215w BRAFLDRAFT_56711 WNT7A fzd8b fzd8a CYIIIB CYIIIA BRAFLDRAFT_114976 DICPUDRAFT_90232 FRK v1g188243 GPRFZ2 GPRFZ4 CTNND2 CTNND1 TVAG_337240 Ctnnb1 wnt3a CDH9 Cdh9 Cdh8 CDH8 Cdh7 CDH7 CDH6 Cdh6 CDH5 Cdh5 CDH4 Cdh4 Cdh3 CDH3 PHYPA_005833 CDH2 Cdh2 CDH1 Cdh1 1276254 LOC100176797 acnA 37852 v1g169611 BRAFLDRAFT_58093 AgaP_AGAP009711 PCDHAC2 PCDHAC1 v1g234494 wnt4a Egfr cdh17 SNOG_01139 actg1 BRAFLDRAFT_113587 LOC100185123 CkIIbeta2 GPRSTN BRAFLDRAFT_116948 Celsr3 Celsr1 Celsr2 Act5C v1g245041 BRAFLDRAFT_114535 CkIIbeta CadN lin-44 CBG02167 acta2 v1g242065 BRAFLDRAFT_126324 CBG02162 CBG02161 ACT1B ACT1A IscW_ISCW024111 ACT1C wnt11 ACT12 ACTR2 Csnk2b cdh-4 cdh-5 wnt7aa cdh-3 Pcdh1 TVAG_054030 ACTBL2 BRAFLDRAFT_115565 BRAFLDRAFT_115566 LOC100028958 pcdh8.2 actc2 Src SRC actc1 4576288 act9 act3 wnt10a Ptpn1 wnt10b Pcdh8 actba Pcdh7 Pcdh9 actbb FYN Fyn AgaP_AGAP009731 PCDH1 AgaP_AGAP009734 fz3 fz2 Act1 ACT1 PTPN1 fz4 AgaP_AGAP009716 PCDH9 PCDH7 PCDH8 LOC100016601 ACT2A act1 fyna fynb csnk2a2a fzd10 Pcdhb2 Pcdhb1 Pcdhb8 Pcdhb7 BRAFLDRAFT_104698 Pcdhb9 Pcdhb4 Pcdhb3 ACTB Pcdhb6 Pcdhb5 ACT9 Act7 ACT7 Wnt10a Act5 ACT4 ACT5 ACT2 Wnt10b ACT3 LOC108348771 EHI_107290 csnk2b Actb Pcdha4 Actr2 CSNK2B GL50803_0040817 AgaP_AGAP007924 actb LOC108348201 TRIADDRAFT_63375 Pcdhb16 PCDH10 Pcdhb17 Pcdhb18 ctnnb1 Pcdhb19 ctnnb2 PCDH15 PCDH12 PCDH19 PCDH18 1278050 IDA5 Pcdhb12 Pcdhb13 Pcdhb14 1281582 Pcdhb15 Pcdhb10 LOC100092493 Pcdhb11 YES1 kin-3 Yes1 PCDH20 8041862 TVAG_512800 stan Pcdhb20 Pcdhb21 CkIIalpha Pcdhb22 tcf7l1a BRAFLDRAFT_118309 BRAFLDRAFT_127490 wnt8a wnt8b kin-10 AgaP_AGAP006732 wnt5b wg LOC100073534 AgaP_AGAP003579 PHYPA_016713 PCDHB15 BRAFLDRAFT_127489 PCDHB14 PCDHB13 CNA04650 PCDHB12 PCDHB11 PCDHB10 BRAFLDRAFT_127488 Ctnnd2 Ctnnd1 PCDHB16 CTNNB1 PF14_0124 PHYPA_016711 PCDH11Y PCDH11X Act88F CELSR1 CELSR2 actc1b actc1a ACTG2 CELSR3 ptpn1 ACTG1 tcf7l1 Wnt5a Os05g0438800 Wnt5b WNT5B WNT5A PCDHA13 PCDHA12 PCDHA11 PCDHA10 Pcdhgc5 pcdh8 Act42A BRAFLDRAFT_115291 wntD Wnt6 WNT6 Wnt5 BRAFLDRAFT_60743 CDH20 Cdh24 v1g210933 Wnt3a Cdh23 CDH22 CDH23 Cdh22 TRIADDRAFT_56111 CDH24 Cdh20 WNT1 Wnt2 WNT2 Wnt1 WNT3 Wnt4 Actg1 Wnt3 Actg2 WNT4 wnt3 wnt2 wnt1 WNT3A BRAFLDRAFT_94959 wnt5 Wnt2b FER Fer Act79B GSK3B GSK3A AgaP_AGAP002310 PCDHGB7 WNT2B PCDHGB6 PCDHGB5 PCDHGB4 WBGene00275837 PCDHGB2 acta1b BRAFLDRAFT_271417 actr2 Cdhr1 hmr-1 actr2a PCDHGA8 PCDHGA7 Arp53D PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 WNT16 ACTA2 acta1a Gsk3b Cdh18 ACTA1 1273990 Cdh17 Cdh15 act10 Cdh13 CDH10 CDHR1 1281498 CDH11 Cdh12 CDHR2 CDH12 LOC100020439 Cdh11 PCDHGB1 CDH13 Cdh10 CDH15 CDH16 act18 CDH17 CDH18 Wnt16 CDH19 LOC485469 actr2b Wnt11 Lef1 arx-2 mom-2 LEF1 mom-5 WNT11 pcdhb zgc:86598 ERBB3 ERBB4 act23 ERBB2 BRAFLDRAFT_56698 act22 1276914 WBGene00098673 TCF7L2 Actc1 TCF7L1 Actbl2 Pcdh11x_predicted PCDHGC5 PCDHGC4 PCDHGC3 Act87E slr2046 ACTC1 lef1 BRAFLDRAFT_56687 Erbb2 Cad88C Erbb4 Erbb3 FZD10 fzd2 Pcdh10 fzd4 fzd5 fzd7 gsk3ba Pcdh19 Pcdh18 Fzd10 Pcdh12 gsk3bb Pcdh15 Acta1 Acta2 CARNITINE METABOLISM%PANTHER PATHWAY%P02733 Carnitine metabolism SCO2032 yfdE caiB PA0446 PA3733 ZK892.4 Dmel\CG10877 Sugct SUGCT PA3592 SSO3144 GASTRIN_CCK2R_240212%PANTHER PATHWAY%P06959 Gastrin_CCK2R_240212 GUCY2D ROCK1 SRC SRF ODC1 ADCY1 NR2C2 PTGS2 CAMKK1 HDAC7 AKAP1 CDC42 MAPK9 MAPK8 PAK1 MAPK7 GNG2 PTK2B MAPK1 CSK MEF2D EIF4E MAPK3 CSNK1A1 BAD STAT3 CCK PTPN11 KLF4 MAPK14 TPCN2 TPCN1 MAPK10 RPS6KB1 CAMK4 BAX CTNNB1 BCAR1 ATF2 IRS1 ARAF CLU ELK1 ELK4 RPS6KA3 RGS2 CDH1 PLAU PRKACG RPS6KA1 AKT1 PRKACA PRKACB AP2M1 MEN1 IER3 MAP2K4 MAP2K1 MEF2C MAP2K2 PRKCH MEF2B PRKCB PRKCE RPS6 PRKCD CSNK1D PRKCA CSNK1E TPST1 PRKCQ PRKD2 PRKD1 RAF1 CETP SHC1 ARHGEF28 PDE1A PXN ITPR1 CREM PIK3R1 FOXO3 FOXO1 EIF4EBP1 PLCG1 MAP2K5 MAP2K6 LYN EGR1 JUN YES1 NFATC2 BRAF PTK2 NFKBIA RHEB SP1 GNB1 SP3 BCL2 SNAI1 CPE GRB2 TCF4 CALM1 MAP3K14 MAP3K11 BCL2L1 RYR1 ITGB1 RYR2 GSK3B CXCL8 YWHAB PTEN HSPB1 PIK3CB ARRB2 ELAVL1 RYR3 ARHGAP4 PPP3CA CASP3 CD38 ITGAV GAST RAC1 NOS1 JAK2 PRKG1 SLC18A2 PDPK1 MMP3 PLA2G4A FOS RHOA DNM1 CNKSR1 CREB1 CCKBR TRAF6 AKT1S1 PPARG SOS1 CRK HBEGF CELL CYCLE%PANTHER PATHWAY%P00013 Cell cycle Ccne2 Psme3 Tb927.2.2440 psmd11b Psmd12 Psmd11 CCND3 PSMD7 CCND2 PSMD4 CCND1 e2f3 eif3f Psmd14 Psmd13 PSMD3 ccnk-1 Tb11.02.2210 cycB Tb10.70.4510 CCNE2 CCNE1 PSME3 CINP BRAFLDRAFT_283521 cye-1 ccnb1 RPN6 PSMD12 PSMD11 PSMD14 PSMD13 RPN3 PF3D7_1337100 Rpn9 Os05g0371200 LMJF_21_0760 Rpn10 psme2 RPN11 Tb10.70.6360 ccne1 rpn-8 Psmd7 rpn-6 Ccnd3 Psmd3 Ccnd1 Tb927.8.570 Tb10.61.0600 Psmd4 Cinp RPN8A rpn6 rpn10 Tb10.61.2180 CycB RPA3 rpn3 E2f1 rpn9 rpn8 Tb11.18.0013 psmd11a Ccne1 CHOLESTEROL BIOSYNTHESIS%PANTHER PATHWAY%P00014 Cholesterol biosynthesis erg9 hmgB erg7 Pmvk erg1 MVD Mvd SQS1 SQS2 Fdps Idi1 MVK Mvk IDI2 Idi2 SQE5 SQE6 SQE3 HMGCR Fpps SQE1 SQE2 hmgA Sqle LMJF_31_2940 PMVK fps1 PDSS1 1276514 FDFT1 FDPS fdps-1 fpp fps SQLE MVD1 spo9 MVD2 Hmgs Hmgcr 1269998 FPPS1 mvd1 CELE_Y48B6A.13 ERG20 Fdft1 Hmgcs1 Ggps1 ERG1 1281561 NCU01119 ERG7 ERG9 CG10268 HMGCS1 GGPS1 Lss LSS LOC_Os03g59040 DICPUDRAFT_149815 LMJF_13_1620 CHORISMATE BIOSYNTHESIS%PANTHER PATHWAY%P02734 Chorismate biosynthesis aroK qa-2 DHQS aroC aroB F27K7.11 aroE aroD aroA aro-1 aro-2 BT_3975 EMB1144 EMB3004 DR_0077 SK1 SKL1 SK2 aroQ aroA1 aroA2 BT_4215 ARO2 SCO1498 ARO1 Os06g0133900 NCU04358 aroKB yqhS aro1 SPCC1223.14 CIRCADIAN CLOCK SYSTEM%PANTHER PATHWAY%P00015 Circadian clock system CLOCK Csnk1e PHR2 VAMP2 per2 clockb per3 clocka Cry1 Cry2 Clock Os04g0452100 ARNTL cry3a cry3b dco cry1a cry1b per csnk1da cry5 csnk1db cry1 CSNK1D CSNK1E cry cyc arntl1a PER2 Per2 Per1 PER1 PER3 Per3 Os02g0573200 per1b CRY2 csnk1d CRY1 Csnk1d Arntl COBALAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02735 Cobalamin biosynthesis cobC NCU09489 COENZYME A BIOSYNTHESIS%PANTHER PATHWAY%P02736 Coenzyme A biosynthesis PANK4 coaD PANK2 PANK3 LA_3936 PANK1 pnk-4 pnk-1 CAB5 Dmel\CG5828 COAE Os01g0360600 coaBC T05G5.5 At4g35360 CAB1 PPCS CBG10005 ANIA_09446 Dcakd coaE SPBC4B4.01c AgaP_AGAP011715 RB7087 DCAKD SPCC14G10.01 dfp Pank3 Pank2 fbl Pank4 HAL3A Dpck Ppcs AgaP_AGAP010073 Pank1 HAL3B 1274567 COENZYME A LINKED CARNITINE METABOLISM%PANTHER PATHWAY%P02732 Coenzyme A linked carnitine metabolism SCO2032 yfdE Rv1866 caiB PA0446 PA3733 ZK892.4 Dmel\CG10877 Sugct SUGCT PA3592 SSO3144 CORTOCOTROPIN RELEASING FACTOR RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04380 Cortocotropin releasing factor receptor signaling pathway gng12a gnb1 gnb2 LOC694289 DICPUDRAFT_93216 gpb-2 gpb-1 crhr1 Gbeta13F gnb1b egl-30 1277119 Gng10 Galphaf CRHR1 CRHR2 Gbeta76C GNG10 Gnal 8035476 gna11b Gnaq BRAFLDRAFT_220697 Gnas Galphas Galphaq nSyb SNAP-25 gpc-1 Gngt2 gnal gnaq GNG12 Snap29 pomca Snap24 GNAL Snap25 pomcb Snap23 GNB2 Gnb2 GNAQ GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 Gnaq1 gngt2a snap-29 SNAP23 crhb stx3b 1276578 1276579 git5 GNGT2 STE4 Crhr2 Syb SNAP29 Crhr1 Vamp8 sfaD SNAP33 1276580 Vamp1 SNAP30 Vamp3 Vamp2 SS1G_03482 VAMP8 gnb5b GB1 CRH Crh gsa-1 gnb5a VAMP1 VAMP2 VAMP3 Gna11 snb-1 CND03830 syb1 ric-4 vamp8 Gna14 vamp2 SNC2 SNC1 GNA14 GNG3 Gng3 1281667 GNG2 Gng2 Pomc GNG5 Gng5 Gng4 GNG4 GNG7 GNA11 Gng7 snap25a GNG8 snap25b Gng8 STX3 Stx3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 POMC gnb3b gnb3a gpbA aex-4 CYSTEINE BIOSYNTHESIS%PANTHER PATHWAY%P02737 Cysteine biosynthesis cysK EHI_024230 OASB cysE OASC cysteine At1g55880 RCS1 yrhA TM_0665 cysB SCO2910 CYSD2 OASTL4 FN1055 CYSD1 Os04g0165700 CBS Cbs SCO3077 RCS3 ytkP PA2104 LA_1598 Os06g0564500 cysM DES1 mccA CYS4 Os06g0149700 cysK1 OASA1 OASA2 MCY1 CS CYSC1 FN1220 1272101 cbs cys12 cys11 cysl-4 cbs-1 cysl-2 PA0399 cysl-3 cysl-1 DR_0789 CYTOSKELETAL REGULATION BY RHO GTPASE%PANTHER PATHWAY%P00016 Cytoskeletal regulation by Rho GTPase LMJF_08_1230 Arhgef1 IDA5 Tub6 tubC Tub4 Tub3 Tub2 TUB2 tubB Tub1 TUB1 1281462 rhoA RHO1 Rho1 LOC100092493 VASP LOC100079040 rho5 TVAG_512800 DICPUDRAFT_47166 rho1 rho4 pfn-3 racE pfn-1 WASL Rhoc zgc:55461 Enah BRAFLDRAFT_127490 Rhoj Rac2 RAC2 racA RAC3 mec-7 Rhou Rac1 RAC1 racB WBGene00111311 Diaph3 Diaph1 TUBB rac1 RHOC RHOB ENAH PGTG_12204 LMJF_21_1860 tubb RHOJ ARHGEF1 RHOU tbb-1 GL50803_00101291 tbb-2 LOC100184511 tbb-4 rac-2 tbb-6 PAK1 Pak1 LOC100073534 Pak6 PAK6 Pak3 PAK3 Pak2 PAK2 PAK5 Pak5 PAK4 Pak4 PHYPA_016713 RAC6 RAC5 BRAFLDRAFT_127489 CNA04650 pak2 BRAFLDRAFT_127488 pak4 DAPPUDRAFT_300845 PF14_0124 ben-1 PHYPA_016711 proA proB betaTub85D cRac1A proC EHI_181250 Act88F actc1b actc1a ACTG2 ACTG1 rac1a rac1b BATDEDRAFT_15405 EHI_197840 Os05g0438800 v1g118944 zip MYH15 SS1G_04652 MYH1B rac1A rac1B EHI_070730 BATDEDRAFT_37213 MYH1G arpc1a Act42A arpc2 myhz1.2 BRAFLDRAFT_115291 myhz1.1 tubb2 Myh11 Myh14 myhz1.3 PFY1 Myh13 tubb6 tubb5 Myh10 BRAFLDRAFT_60743 myhc4 v1g210933 1271023 MYH13 TRIADDRAFT_56111 MYH14 MYH11 MYH10 Actg1 Actg2 BRAFLDRAFT_278128 PRO1 8026889 ninaC Ssh3 Ssh2 TB927.1.2330 BRAFLDRAFT_94959 betaTub60D SSH1 DIAPH1 DIAPH2 DAPPUDRAFT_306746 Act79B RhoGAP68F cdc42 Prr5 BRAFLDRAFT_60807 WBGene00275837 8026892 acta1b ARC40 myhb myha Arp53D ACTA2 acta1a MYH1 arpc5b ACTA1 Myh1 MYH2 Myh2 Myh3 MYH3 act10 1281498 Myh8 MYH8 LOC100020439 MYH9 Myh9 MYH4 act18 Myh4 MYH6 Myh6 MYH7 Myh7 arx-3 arx-5 TRIADDRAFT_20369 rac3a act23 BRAFLDRAFT_56698 rac3b act22 zgc:65894 v1g243859 arx-6 WBGene00098673 SS1G_03867 Actc1 Actbl2 LIMK1 Act87E ACTC1 Limk1 BRAFLDRAFT_56687 BRAFLDRAFT_120208 arcA v1g245773 STMN4 arc3 arc2 arc5 MYLK arc4 chic STMN1 Tb11.01.5350 nda3 BRAFLDRAFT_126918 arcC arcB arcE arcD Acta1 Acta2 tubb2b PF10_0084 SS1G_08733 myo3a BRAFLDRAFT_114958 arc1 act-2 act-1 Arhgap1 DICPUDRAFT_48914 act-4 act-3 act-5 BRAFLDRAFT_79607 TVAG_090470 BRAFLDRAFT_122664 Stmn1 rock2a 8036844 Myh7b BRAFLDRAFT_215305 Stmn4 ARC19 MYH7B ARC18 betaTub56D ARC15 Mylk ACT Act Os12g0163700 DICPUDRAFT_46519 cdc3 tubb4b ARHGAP8 ARPC1B ARPC1A ARHGAP1 v1g229095 act AgaP_AGAP000406 Tb09.211.0620 BRAFLDRAFT_125401 actin TUBB2B TUBB2A DAPPUDRAFT_305638 LOC100029767 Act57B PGTG_05488 Rop3 TRIADDRAFT_49626 cfl1 Os05g0106600 TVAG_008680 UMAG_11232 PFL2215w TUBB4B TUBB4A WBGene00273840 CYIIIB CYIIIA BRAFLDRAFT_114976 cRhoB DICPUDRAFT_90232 Tubb4b Tubb4a v1g188243 AGOS_ACR225C MYLK2 rga-1 TVAG_337240 MYLK3 TUBB8 TUBB7 TUBB6 TUBB5 PHYPA_005833 TUBB4 TUBB3 LOC100176797 CFL2 TUBB2 TUBB1 CFL1 acnA 37852 v1g169611 BRAFLDRAFT_58093 TUBB9 TRIADDRAFT_63686 Tubb2b Tubb2a Cfl1 v1g234494 Cfl2 BRAFLDRAFT_124235 v1g236559 SNOG_01139 Mylk2 DAPPUDRAFT_301996 DAPPUDRAFT_302845 benA actg1 LOC100185123 PHYPA_011051 BRAFLDRAFT_116948 Act5C Tubb5 LOC750209 myh10 Tubb6 Tubb3 Arpc1 Arpc3 Tubb1 Arpc2 ARPC4 ARPC5 8029221 ARPC2 ARPC3 BRAFLDRAFT_114535 1281871 Arpc5 Arpc4 mbt Myo3a CBG02167 acta2 v1g242065 BRAFLDRAFT_126324 CBG02162 CBG02161 ACT1B ACT1A IscW_ISCW024111 ACT1C EHI_176140 ACT12 CG32396 Rok TVAG_054030 ACTBL2 MYO3B let-502 MYO3A BRAFLDRAFT_115565 Evl BRAFLDRAFT_115566 LOC100028958 TVAG_034440 DICPUDRAFT_85721 v1g167737 actc2 ROCK1 Os10g0323900 ROCK2 actc1 PHYPA_003231 act9 act3 CDC42 actba actbb cof1 Cdc42 Act1 ACT1 LOC100016601 pak-1 ACT2A act1 WBGene00092447 1279875 Rock2 Rock1 tub-2 COF1 ssh PRF3 PRF2 mlck-1 myhz2 ACTB PRF4 Arpc3B ACT9 Act7 ACT7 Act5 ACT4 ACT5 ACT2 ACT3 LMJF_33_0792 EHI_107290 rho-1 Actb Arpc1b Arpc1a GL50803_0040817 PFN1 Pfn1 actb PFN3 Pfn3 Pfn2 PFN2 Vasp TRIADDRAFT_63375 DE NOVO PURINE BIOSYNTHESIS%PANTHER PATHWAY%P02738 De novo purine biosynthesis BEST:GH11240 Dmel\CG11811 PPAT LMJF_04_0460 ASE1 Os06g0168600 ASE2 ras nrdJa AgaP_AGAP009660 ANIA_00067 TVAG_489800 cdc22 nme7 guk-1 nme6 gmk NDPK3 NDPK2 AgaP_AGAP010198 At2g39270 Tb11.v4.0006 Tb11.v4.0007 Tb11.v4.0004 PF3D7_1405600 Tb11.v4.0005 ASE3 At5g35170 nme3 Prat2 ppat-1 SPBC1198.05 1272085 Ppat bur adB slr0591 ADK nmdyn-D6 F38B2.4 adssl ATIC GUK1 Guk1 1273584 CBG17377 Gart CBG05718 Tb11.02.5720 Os11g0312220 adk1 adk2 Nme3 NME2 NME3 adk LMJF_34_0120 Nme2 NME4 Nme5 NME5 LmjF13.1190 gart Nme1 NME1 IMD2 IMD3 Atic ADK2 NME6 Nme7 NME7 Nme6 Adk2 IMD4 ADK1 ADSSL1 Os02g0778400 DSCAML1 GART PUR2 suc22 At3g01820 RNR2A PURA purN PAE0218 purA purB CELE_F38B6.4 purD PF3D7_0920800 L1648.07 LOC100359539 atic-1 purE PF3D7_1437200 purF purH awd ndkC-2 PAE0226 Dscaml1 EHI_135470 At1g63660 At2g35040 nrdZ nrdB1 AgaP_AGAP010139 BT_1998 nrdB nrdA nrdB2 nrdF nrdE ADE57 nrdD LOC_Os10g41410 IMPDH FN0368 nrdJ At4g18440 nrd Ak1 Ak3 Ak2 Ak5 Os03g0130400 Ak4 swoH IMH3 Ak8 nme2b.2 MA_1376 PURA1 YNK1 PAE3155 LOC480491 rnrB-2 T22D1.3 At1g36280 guaB1 ak1 AK1 GMPS AK2 AK3 AK4 AK5 ndkM SCO5226 AK8 RnrL LMJF_21_1250 URA6 PA3516 NDK1 FN0103 NDK4 RnrS LMJF_04_0960 adsl-1 guaA guaB GUA1 ndkA FN0102 CBG03104 impdh1b impdh1a Adss2 Adss1 gua1 ndk1 guaAA Tb11.01.7800 ndk 1281753 guaAB DR_B0109 RNR4 DR_B0108 ADSS1 RNR2 ADSS2 RNR3 LMJF_19_1560 RNR1 impdh1 impdh2 Rrm2b nrdF1 DR_2374 ADK-A nrdF2 ADE12 rrm2 rrm1 ADE16 let-754 ADE13 adss-1 ADE17 rnr-1 rnr-2 ADSL 1269986 Gmps GK-2 GK-1 AgaP_AGAP011133 TM_0118 RRM2B 1272781 NDKR PF3D7_1012600 1270247 ZK673.2 purA1 Tb09.211.0350 purA2 AdSL Adsl ade10 Impdh2 UMK3 Impdh1 adk-1 GK3 PAE0972 ADSS RRM1 ade1 Rrm1 Rrm2 RRM2 ndk-1 yosP 1279199 ADE4 ADE1 PF3D7_0415600 Prat IMPDH1 PF3D7_0206700 IMPDH2 SCO1461 UMK2 purF-1 UMK1 purF-2 ade8 Adss AdSS 1270820 ade2 nrdEB FN0311 LOC100856570 ade4 DE NOVO PYRIMIDINE DEOXYRIBONUCLEOTIDE BIOSYNTHESIS%PANTHER PATHWAY%P02739 De novo pyrimidine deoxyribonucleotide biosynthesis nrdB CDC21 nrdA tmk At2g21550 nrdB2 nrdF nrdE nrdD LOC_Os10g41410 nrdJ Os06g0168600 nrd Tyms Tb927.7.5480 CBG09150 swoH SPAC15E1.04 nme2b.2 Dmel\CG5292 1272582 YNK1 PAE3155 nrdJa ANIA_00067 rnrB-2 TMP1 cdc22 guaD DEADC1 NDPK3 AgaP_AGAP010198 NDPK2 ndkM SCO5226 tad2 RnrL NDK1 FN0103 Tb11.v4.0006 Tb11.v4.0007 Tb11.v4.0004 PF3D7_1405600 NDK4 Tb11.v4.0005 RnrS nme3 dut-1 gll3510 FN0102 ndkA 8032909 Dmel\CG5757 dUTPase dtmk-1 CDC8 tmk1 thyA ndk1 Tb11.01.7800 ndk DR_B0109 RNR4 DR_B0108 RNR2 RNR3 RNR1 SPAC644.05c slr0591 Rrm2b nrdF1 AgaP_AGAP005260 DR_2374 TADA MA_3407 DUT1 nrdF2 LmjF06.0860 rrm2 yfhC rrm1 Ts Tb11.02.5720 rnr-1 CELE_JC8.4 rnr-2 1269986 Nme3 NME2 Nme2 NME3 NME4 tilS Nme4 Nme1 NME1 TM_0118 RRM2B PF3D7_0417200 CELE_Y48A6B.7 NDKR 1270247 tadA TAD2 DSCAML1 DTYMK dcd thyA2 thyA1 SCO4974 suc22 tmp1 TYMS RNR2A DDB0230112 AgaP_AGAP010159 Dtymk tyms RRM1 DUT Dut Rrm1 RRM2 Rrm2 ndk-1 L1648.07 LOC100359539 yosP PF3D7_1437200 ADAT2 awd ndkC-2 nrdEB Adat2 FN0311 Dscaml1 tyms-1 dut TM_0385 THY-1 nrdZ NCU07773 nrdB1 CELE_R13A5.10 BT_1998 DE NOVO PYRIMIDINE RIBONUCLEOTIDES BIOSYTHESIS%PANTHER PATHWAY%P02740 De novo pyrimidine ribonucleotides biosythesis dhod-1 nme2b.2 PF3D7_1344800 YNK1 Os01g0654100 GL50803_0017587 SPCC1795.05c URA3 URA2 NDPK3 URA1 NDPK2 Cps1 ndkM At2g34890 URA8 URA7 URA6 URA5 NDK1 Dhod NDK4 nme3 ndkA ctps-1 ura7 ura4 ura5 R12E2.11 TB927.1.1240 ndk1 Tb11.01.7800 r CTPsyn CPS1 ndk 1281078 ura3 ura1 pyr-1 PF3D7_1410200 At1g30820 1271961 8025216 carB1 carB2 1269986 CAD Cad Nme3 NME2 Nme2 NME3 CTPS2 CTPS1 NME4 ura-5 Nme4 Nme1 NME1 arg5 arg4 URA10 Ctps2 PFF0160c 1273997 NDKR Ctps1 DSCAML1 AgaP_AGAP009624 carB carA PYR6 pyrABCN r-l LMJF_16_0540 PYRB PYRD Dhodh ndk-1 L1648.07 pyrE pyrF pyrG T2E22.2 At4g20320 pyrB DHODH pyrD awd pyrBI ndkC-2 LMJF_16_0550 arg-2 Dscaml1 pyrAB pyrAA CARB PAE3263 CARA LOC_Os10g41410 CPA2 CPA1 ANIA_05909 swoH DNA REPLICATION%PANTHER PATHWAY%P00017 DNA replication dpo3 rnhA Pcna rnhB BATDEDRAFT_20154 His3.3B LMJF_16_1540 top-1 LMJF_28_2280 v1g159483 rnh1 hh3 rtcB BRAFLDRAFT_108838 TRIADDRAFT_24875 PGTG_00393 Dna2 DNA2 HIST2H3D PF3D7_0308000 BRAFLDRAFT_97692 H3c8 DAPPUDRAFT_231307 Pola1 PGTG_06938 ssb2 PF3D7_0617900 top1 zgc:173552 top2 PGTG_11296 Tb927.8.4880 At5g65350 RNASEH1 his-9 Tb09.160.4090 1280490 cdc1 v1g230009 v1g194445 Os06g0160100 LOC100297725 POLA1 HIS3A PF3D7_1226600 HHT1 v1g227757 hhtA H3c7 HHT3 Tb927.7.4930 HHT2 TOP2A Hist2h3c2 TOP2B his-71 his-72 pcn1 pcn2 His3:CG33866 CBG03775 Os02g0805200 HHT21 pcn3 his-74 At1g75600 DNApol-delta PF3D7_0610400 v1g148952 CNB00570 rpa2 H3-3B Pold2 Rnaseh1 RFC5 Rfc5 Pold1 RFC3 Rfc3 RFC4 Rfc4 RFC1 H3f3c Rfc1 RFC2 Rfc2 At1g13370 MA_0885 his-63 BRAFLDRAFT_125364 21514 Prim2 pol3 NCU03763 Top2b Prim1 Top2a THAPSDRAFT_29950 priS TOP2 Top2 TOP1 Top1 H3-3b PCNA LOC100013629 PRIM1 8025862 RNH70 PF3D7_0411900 pcna PGTG_06100 POLD1 LOC115945174 POLD2 Os06g0130900 H3-X EHI_120640 pcn PF3D7_1017000 HTR41 TRIADDRAFT_36142 LOC693939 TOP1A RGD1564447 TOP1B SS1G_09608 Top1mt 20088 RPA2 8027010 H3-2 H3-5 H3-4 RPA2A PGTG_01862 RNH1 pold2 RECQL4B BRAFLDRAFT_67487 v1g231526 v1g196043 HTR2 hht2 hht3 HTR8 HTR9 v1g227545 h3f3d PNAT%PANTHER PATHWAY%P05912 PNAT Adcy7 SNAP29 ppp1cc Syb SLC18A2 Slc6a3 Gnaz Maoa Vamp8 Maob SNAP33 Vamp1 Prkaca Prkacb SNAP30 Vamp3 DAPPUDRAFT_319998 Vamp2 VAMP8 Epb41 GPRDOP1 Gnai2 prkacaa VAMP1 Gnai1 1270763 VAMP2 Pp1-87B VAMP3 prkacab Gnai3 DDC Ddc syb1 snb-1 v1g240980 ric-4 vamp8 GNAI3 vamp2 ADCY2 PRKX SNC2 ADCY7 LmPKAC2b GNAI1 GNAI2 Pp1alpha-96A SNC1 drd1a Kcnk3 Clic6 drd1b GNG3 Gng3 GNG4 prkar2ab Gng4 snap25a snap25b FLNA Gng8 GNG8 Stx3 STX3 AgaP_AGAP004940 Ppp1cc ddc gng3 Prkar2a Prkar2b ple Kcnk9 PPP1CA LOC112204126 1281793 TRIADDRAFT_30170 aex-4 KCNK3 gnb1 gnb2 pkaC grb2 COMT PPP1CB PPP1CC Comt PRKACG Slc18a2 gnai3 dop-1 PRKACA gnai1 PRKACB Ppp1ca drd2l pkac1 Prkx bas-1 drd2b gnb1b LMJF_35_3960 Pka-R2 drd2a Flna DAPPUDRAFT_194510 th2 Pka-C1 GNAZ Pka-C3 MAOB EPB41 MAOA gsp-2 gsto1 AgaP_AGAP009091 Epb41l1 35258 EPB41L1 PRKAR2B PRKAR2A EPB41L2 EPB41L3 prkacbb prkacba mao DRD1 Drd1 cat-2 DRD2 Drd2 DRD3 Drd3 nSyb kcnk3a DRD4 Drd4 SNAP-25 Drd5 DRD5 kin-1 TYRDC grb2a BRAFLDRAFT_219190 GNG11 Snap29 drd5 Snap24 drd3 Snap25 CDK5 TH Snap23 GNB2 Gnb2 GNB1 Gnb1 PPP1R1B GNB4 Gnb4 GNB3 Gnb3 ppp1cab Gng11 hdl-1 ANIA_08769 DAPPUDRAFT_231787 Pp1-13C AgaP_AGAP008039 CLIC6 SNAP25 KCNK9 snap-29 SNAP23 DBH Dbh stx3b SLC6A3 Ppp1r1b Dop1R1 Th Tdc2 LOC_Os10g23900 Adcy2 Tbh DPP-SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06212 DPP-SCW_signaling_pathway dpp scw tsg sog Smurf sax Med tld put alph Fur1 Mad nej shn Pdp tkv DPP_SIGNALING_PATHWAY%PANTHER PATHWAY%P06213 DPP_signaling_pathway dpp tsg sog Smurf Med tld put alph Fur1 Mad nej Pdp tkv EGF RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00018 EGF receptor signaling pathway UMAG_03305 Prkd3 Erbb2 Erbb4 Erbb3 UMAG_01366 ARAF hog-1 Prkd1 Prkd2 akt2l vps-34 BRAFLDRAFT_123893 akt3b SYNGAP1 GRF13 GRF10 GRF11 pik3cd AKT2 Akt3 Akt2 AKT3 Tb11.01.8740 Akt1 AKT1 EHI_129750 VPS34 BRAFLDRAFT_126918 p38b p38a DDB0167309 PRKCG PRKCI LOC_Os03g62730 PRKCH ywhaz PRKCB PRKCE RTS1 PRKCD Plcg1 Araf PRKCA Pkc53E Prkcq Plcg2 CEN HOG1 Prkcg Prkch Prkci Prkcb PRKD3 Prkcd Prkce PRKCQ PRKD2 PRKD1 Prkca wis4 mapk14a Os01g0691700 HD3A ywhab PRKCZ par-5 pph-1 CNL03930 sli-1 BRAFLDRAFT_113834 shc-1 PLCG2 LOC_Os12g05590 mapk14b ftt-2 SFN Sfn PLCG1 Prkcz grb2a grb2b Pik3c2b BRAF Pik3c2a SS1G_05445 Dsor1 Pik3c2g Stat5a Stat5b PHYPA_015383 spk1 pho2a Stat6 Stat4 RAS2 MRPL38 RAS1 AREG Hbegf 8041094 Shc 11176082 Mras rasD rasG mek-2 B'ETA rasS mras rasA RRAS2 rasC SIRT6 rasB AGOS_AGR107C Areg LMJF_10_0200 MRAS NCU00656 spm1 Dmel\CG6180 Pik3r5 byr1 ras1 Pik3r6 1273239 kgb-1 HBEGF kgb-2 pikB nras pikC Rop3 pikE hrasb hrasa EGFR FT sty1 NRAS STAT4 STAT6 pikA STAT1 STAT2 Ask1 STAT3 PHYPA_029693 DAB2IP wrd EHI_006810 NCU01642 mpk-1 Stat3 mpk-2 Stat2 Stat1 LOC685590 Dmel\CG7054 SMK1 Map3k5 Map3k4 rhog2 skh1 MAP3K4 MAP3K5 Ppp2cb MAP2K3 MAP2K4 Ppp2ca MAP2K1 MAP2K2 akt-2 akt-1 ced-10 Egfr Map3k3 Map3k2 Map3k1 Nras TB927.1.1930 SS1G_13801 ppp2r5cb cpras1 smg-1 GF14A SS1G_11866 CEK1 ARAC4 ARAC9 PHLDB2 ARAC7 ARAC8 EHI_025360 Shc3 SHC2 Shc2 SHC3 Shc1 SHC1 PP2A3 GF14C PP2A4 NCU06500 GF14B dos PP2A5 RASAL2 GF14D GF14G GF14F sta-1 PP2A1 PP2A2 MAPKKK3 LOC100012174 CELE_F09C12.2 BCK1 Nf1 MAP2K7 MAP2K6 11175838 v1g247341 DAPPUDRAFT_307391 stat1a nfh-2 DAPPUDRAFT_326737 B'BETA Sos NF1 lin-45 1271952 jnk-1 KSS1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B PPP6C MFT2 NCU01112 B'ALPHA drk TSF Ppp6c mapk3 NRG1 Nrg2 Nrg1 NRG2 mapk1 Nrg4 PIK3CA racF2 NRG3 Nrg3 NRG4 PIK3C3 SOS1 nsy-1 let-60 Sos2 SOS2 Sos1 ARAC2 ppa2 spry2 sem-5 gefA gefB racF1 gefE KDX1 SSK22 pebp1 spry4 Mapk12 Mapk13 rhogc Mapk14 rhogb piki-1 plc pik3ca ccm2 ppp2r5ea 1279876 ppp2r5eb NCU03786 ugt1a1 Mapk10 14-3-3zeta Mapk11 Dmel\CG17919 mik-1 Dmel\CG17917 PPH22 MPK4 MPK5 CBLC CBLB anon-SAGE:Wang-129 MPK1 MPK2 Ereg MPK3 MPK8 MPK9 SKP1 gefY mpkB Cblc Cblb ywhaba EREG BTC Btc LOC_Os11g05470 gefK v1g195622 gefP sty bsk Rasa1 14-3-3epsilon TGFA Pi3K92E PIK3R6 PIK3R5 SLT2 Tb10.61.0250 RRAS At1g22290 sl Grap STAT5A STAT5B AgaP_AGAP011036 TRIADDRAFT_63380 3290548 BMH2 BMH1 pck1 pmk-2 pck2 pmk-1 AgaP_AGAP012252 LOC100011470 Grb2 GRAP ywhae1 ywhae2 mtk-1 racG erkB plcg1 Pik3c3 prkci B'ZETA prkcb Rac2 RAC2 racA RAC3 racC Rac1 RAC1 racB HRAS rhoj Gab1 rac1 GAB1 Tgfa Gab3 GAB3 GAB2 Gab2 rhoq Rras ywhag1 ywhag2 1269341 ras-1 1269582 ras-2 os-4 NCU06544 Ppp2r5d Ppp2r5c rac-2 Map2k7 DAPPUDRAFT_301818 Map2k6 ANP3 PPH3 Ppp2r5b Ppp2r5a PPP2CA ANP2 PPP2CB mkh1 stat3 Dab2ip ppp2cab ppp2caa ppp2cb MAP3K2 MAP3K3 MAP3K1 RAC6 RAC7 CBG05964 RAC5 pphA stat5a 1279592 Map2k4 Map2k3 Map2k2 Map2k1 Ppp2r5e GRF2 GRF3 GRF6 GRF5 GRF8 Hras ARAC10 GRF9 Mapk9 cRac1A ppp6c Mapk8 EHI_181250 Mapk1 PEBP1 1282015 AgaP_AGAP011463 Mapk3 rac1a rac1b mak-2 hep EHI_197840 AgaP_AGAP002748 mak-1 PEBP4 dkf-2 Ras85D 1269396 plc1 LMPK vap MPK20 pkc-1 rac1A rac1B EHI_070730 rac1C pkc-3 LOC521224 PF3D7_1113900 RAF1 Raf1 MKK1 MKK2 Mkk4 MKK6 MPK18 MPK15 MPK16 MPK19 B'DELTA 8036204 Rras2 Pik3cg Pik3cb tpa-1 Pik3cd Pik3ca age-1 mapk10 mkkA B'GAMMA FUS3 TFL1 Pbp2 PF3D7_0818200 Stat92E mapk12 pebp1.2 YWHAE SSK2 EHI_098280 par1 RasGAP1 YWHAB par2 CELE_Y69E1A.5 CrMPK2 Ywhaq FTT1 Ywhah Ywhag map2k4a plc-3 Ywhae YWHAQ PPP2R5E Ywhab DDB0167574 DICPUDRAFT_91511 Rasal1 Rasal2 STE11 YWHAG YWHAH RASA4B PPP2R5B vps34 PPP2R5A PPP2R5D PPP2R5C PKC1 fttB YWHAZ mts RASA4 RASA1 RASA2 RFT1 Ras64B AgaP_AGAP000018 ANIA_04501 B'EPSILON Ywhaz Pi3K68D RHOG2 akt2 LOC_Os03g07150 CBL Cbl PHYPA_021214 Phldb2 B'THETA MAPK9 MAPK8 ERBB3 ERBB4 inaC rac3a ERBB2 rac3b MAPK1 RHOGL pptr-2 pptr-1 LOC298795 MAPK3 win1 EGF Egf SPRY4 Pebp4 Spry2 F40A3.3 kras Spry1 Dmel\CG32568 MAPK14 cbl MAPK12 MAPK13 MAPK10 MAPK11 OSJNBa0091F23.19 a5 AgaP_AGAP010273 Spry4 Raf dgcr8 SPRY3 Pebp1 SPRY2 KRAS SPRY1 SNOG_03299 ENDOGENOUS_CANNABINOID_SIGNALING%PANTHER PATHWAY%P05730 Endogenous_cannabinoid_signaling Cacna1g Plcb3 gnb1 Cacna1a Cacna1b gnb2 GRM1 Grm1 Plcb2 Plcb1 GRM5 Grm5 GNGT2 gnai3 gnai1 gnaia PLCB3 gnb1b Gnai1 PLCB1 PLCB2 Gnai3 Gng10 Gnao1 GNAI3 CACNA1B CACNA1A GNAI1 CACNA1G GNG3 Gng3 GNG5 Gng5 GNG4 CNR1 Gng4 GNG7 Gng7 GNG8 Gng8 Gngt2 gng3 Cnr1 GNG11 GNAO1 GNB2 Gnb2 GNB1 Gnb1 GNB4 GNB3 Gnb3 Gng11 UNTITLED%PANTHER PATHWAY%P00019 untitled UMAG_03305 Ednrb Ednra Ac76E ARAF MPK4 MPK5 MPK6 MPK7 MPK1 akt2l MPK2 MPK3 akt3b EDNRA LOC694289 EDNRB prkar1ab AKT2 PRKACG Akt3 AKT3 Akt2 Akt1 AKT1 prkar1aa PRKACA PRKACB AgaP_AGAP009315 Plc21C norpA PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD pkac1 Araf mpkB PRKCA Pkc53E Prkcq 1278166 ednrba pkg-2 Pkg21D Ac3 Prkcg Prkch Prkci ADCY9 LMJF_35_3960 Prkcb PRKAR1B PRKAR1A Prkcd Prkce prkg1b PRKCQ Prkca furin Eef1akmt4-Ece2 PRKCZ edn1 twr Gucy1b1 Gucy1b2 gcy-9 PRKAR2B PRKAR2A gna11b Galphas Prkcz kin-2 kin-1 gcy-32 Dmel\CG30345 Prkg2 Dsor1 pck1 pck2 LA_1929 Prkg1 acgA Gucy1a1 Gucy1a2 Dmel\CG15890 spk1 AgaP_AGAP012252 gcy-36 Plcb4 PCSK1 LMJF_15_1200 AgaP_AGAP003000 Plcb3 egl-8 Pla2g4a Plcb2 egl-4 Plcb1 At1g52600 prkci rut ACXD ACXE ACXB ACXC ACXA prkcb mek-2 Adcy3 Adcy4 Adcy1 Tb11.02.2210 itpr1 Adcy2 AgaP_AGAP009115 Adcy7 Adcy8 Adcy5 Adcy6 SEC11 Adcy9 Edn1 EDN1 Edn2 EDN2 EDN3 Edn3 cya SIRT6 Itpr PLCB3 sec11 PLCB4 prkacaa gsa-1 PLCB1 PLCB2 Ptgs2 prkacab prkchb CNA05510 Prkar1a Prkar1b for ADCY4 ADCY3 NCU06544 ADCY2 ADCY1 ADCY8 PTGS2 ADCY7 LmPKAC2b ADCY6 ADCY5 Prkar2a Prkar2b BCY1 sec-11 AgaP_AGAP002262 ECEL1 Map2k2 Map2k1 mpk-1 1281793 AgaP_AGAP009207 EEF1AKMT4-ECE2 GUCY1B1 Mapk1 pkaC prkcbb Mapk3 prkcba Fur2 Fur1 mak-2 AgaP_AGAP002748 Ecel1 BcDNA:RH31685 1269396 AgaP_AGAP008863 Ac13E GUCY1A2 MAP2K1 GUCY1A1 MAP2K2 akt-2 akt-1 Sec11c Sec11a pkc-1 Pka-R1 pkc-3 Pka-R2 pla2g4a egl-30 SS1G_11866 CEK1 nep-9 RAF1 Raf1 prkar1b prkcda Pka-C1 Adcy10 Pka-C3 MPK10 MPK13 ITPR1 ITPR2 PKAR MPK14 ITPR3 MPK11 Gnal Gnaq 1281188 Gnas prkacbb prkacba tpa-1 gnaq FUS3 Pcsk1 ADCY10 GNAL itr-1 GNAQ pkaR GNAS lin-45 Itpr3 Itpr2 Itpr1 nep-21 AgaP_AGAP006475 KSS1 nep-20 CrMPK2 ECE1 Ece1 Ece2 ECE2 mcb nep-26 plc-2 PF3D7_1223100 PRKG2 gcy-28 PRKG1 AgaP_AGAP002441 mapk3 PLA2G4A Nepl12 CG8970 Prkaca Prkacb PKC1 CG8054 cgs1 PKG mapk1 EDNRB2 Dmel\CG15553 SLC46 Gna11 Ac78C akt2 Gna14 FURIN GNA14 ptgs2b prkar2ab GNA11 inaC MAPK1 Furin SEC11A AgaP_AGAP004940 MAPK3 SEC11C Nos3 NOS3 ptgs2a Raf acy-2 SNOG_03299 Nep7 Nep3 acy-1 At3g15710 ENKEPHALIN RELEASE%PANTHER PATHWAY%P05913 Enkephalin release gnai2a gnai2b goa-1 gnb1 gnb2 pkaC Pdyn LOC694289 Oprd1 PRKACG DICPUDRAFT_93216 gnai3 PRKACA gnai1 PRKACB gpb-2 gpb-1 pkac1 Prkx PDYN gnaia Gbeta13F gnb1b LMJF_35_3960 Pka-R2 BRAFLDRAFT_60318 Oprm1 1277119 pdyn Pka-C1 Pka-C3 Gng10 Gnao1 CREM Galphaf gsto1 Gbeta76C GNG10 Gnal 8035476 Gnao Galphai PRKAR2B PRKAR2A PENK BRAFLDRAFT_220697 Crem prkacbb Gnas prkacba Galphas Galphao kin-1 Gngt2 gnal GNG12 GNAO1 GNAL GNB2 Gnb2 penka 1276442 GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 Gng12 AgaP_AGAP008039 gngt2a oprm1 1276578 1276579 git5 GNGT2 1276572 STE4 gnao1b Adcy2 Adcy7 Creb1 sfaD 1276580 Prkaca oprd1a OPRM1 Prkacb DAPPUDRAFT_319998 SS1G_03482 CREB1 gnb5b Penk GB1 Gnai2 gsa-1 prkacaa gnb5a Gnai1 Gnai3 prkacab OPRD1 CND03830 tmem26 GNAI3 CiGi1 ADCY2 PRKX ADCY7 LmPKAC2b GNAI1 GNAI2 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 prkar2ab Gng4 GNG4 GNG7 Gng7 GNG8 Gng8 AgaP_AGAP004940 gnb-1 gng2 Gbeta5 gng3 Prkar2a gng5 Prkar2b gng7 LOC112204126 gnb3b gnb3a creb1b 1281793 gpbA FAS SIGNALING PATHWAY%PANTHER PATHWAY%P00020 FAS signaling pathway scinla CYT1 Tb927.8.1890 8026073 SCIN lmn-1 CYC1 timm13 FADD Jun JUN mapk10 LMJF_07_0060 Os05g0301700 casp3a Os01g0935700 Decay parp-1 Lam Faslg Daxx parp-2 jnk-1 gsnl-1 FAF1 Faf1 Drep4 FASLG map2k4a LMNB2 LMNB1 CASP9 Parp3 dffb PARP2-A CASP7 CASP8 CASP10 CASP6 CASP3 Parp2 Parp1 BRAFLDRAFT_121709 DFFB PARP3 PARP4 PARP1 mapk8 APAF1 PARP2 AgaP_AGAP011938 faf1 Scin CYC1-1 CYC1-2 Fadd cyc-1 AgaP_AGAP008015 akt2 lmna CAPG MAPK9 MAPK8 LMNA Cflar parp Lmnb1 Lmnb2 Casp8 Casp7 GSN Casp9 Gsn Casp3 AgaP_AGAP003230 Casp6 Capg CFLAR LamC MAPK10 Map2k4 lmnb2 Fas FAS lmnb1 casp8 Mapk10 Dffb Mapk9 Mapk8 PA4429 cyc1 Map3k5 casp AKT2 Akt1 AKT1 Cyt-c1L 1269396 cyt1 MAP3K5 MAP2K4 DAXX akt-1 Parp fbcH Gel Lmna lmnl3 bsk Mkk4 cyt-1 FGF SIGNALING PATHWAY%PANTHER PATHWAY%P00021 FGF signaling pathway UMAG_03305 UMAG_01366 ARAF SS1G_07871 vps-34 BRAFLDRAFT_123893 ppp2r1bb akt3b ppp2r1ba GRF13 GRF10 GRF11 AKT2 Akt3 Akt2 AKT3 Tb11.01.8740 Akt1 AKT1 EHI_129750 VPS34 BRAFLDRAFT_126918 p38b p38a DDB0167309 PRKCG PRKCI PRKCH ywhaz PRKCB PRKCE RTS1 PRKCD Plcg1 PF3D7_0314400 Araf FRS2 Frs2 PRKCA Pkc53E Prkcq Plcg2 FRS3 CEN Frs3 Prkcg Prkch Prkci Prkcb Prkcd PRKCQ Prkca mapk14a Os01g0691700 Os09g0249700 HD3A ywhab PRKCZ par-5 pph-1 PPP4C ppp2r2bb CNL03930 BRAFLDRAFT_113834 PLCG2 LOC_Os12g05590 mapk14b ftt-2 SFN Sfn PLCG1 Prkcz fgf8a grb2a grb2b Pik3c2b Pik3c2a Dsor1 Pik3c2g Fgfr3 Fgfr4 Pp2A-29B Fgfr1 Fgfr2 spk1 PHYPA_030641 FYPP1 pp2A pho2a Fgf16 SNOG_16549 Fgf17 Fgf14 FYPP3 Fgf18 RAS2 RAS1 Fgf12 Fgf13 Fgf10 Fgf11 8041094 Shc 11176082 rasD rasG mek-2 B'ETA rasS rasA Fgf20 rasC SIRT6 rasB AGOS_AGR107C Fgf22 Dmel\CG6180 ras1 B''ALPHA 1273239 pikB nras pikC Rop3 pikE hrasb hrasa FT NRAS pikA Ask1 PHYPA_029693 EHI_006810 mpk-1 LOC685590 PPX1 AgaP_AGAP009207 PPX2 Dmel\CG7054 8041450 Fgf2 FGF1 Map3k6 FGF2 Fgf1 FGF3 Map3k5 Fgf4 FGF4 Map3k4 Fgf3 FGF5 Fgf6 Fgf5 FGF6 FGF7 Fgf8 FGF8 Fgf7 FGF9 Fgf9 MAP3K6 MAP3K4 MAP3K5 Ppp2cb MAP2K3 fgf4 MAP2K4 fgf3 Ppp2ca MAP2K1 MAP2K2 akt-1 ced-10 tng Map3k3 Map3k2 Map3k1 Nras SS1G_13801 GF14A SS1G_11866 CEK1 ARAC3 ARAC4 ARAC9 ARAC7 EHI_025360 Shc3 SHC3 Shc1 SHC1 rgb-1 PP2A3 GF14C PP2A4 GF14B fgfr4 PP2A5 GF14D GF14G GF14F PP2A1 PP2A2 MAP2K7 MAP2K6 fgf14 11175838 v1g247341 DAPPUDRAFT_307391 nfh-2 fgf12 DAPPUDRAFT_326737 B'BETA sur-6 Sos ppp2r2d 1271952 ppp2r2b jnk-1 KSS1 PIK3CD PIK3CB PIK3C2A PIK3CG PIK3C2B B''GAMMA MFT2 paa1 B'ALPHA drk PP2AA1 DAPPUDRAFT_209708 PP2AA2 PP2AA3 mapk8 TSF mapk3 mapk1 ppp2r2ab PIK3CA pph-4.2 pph-4.1 PIK3C3 B''DELTA SOS1 nsy-1 let-60 Sos2 SOS2 Sos1 PP2AB2 B''BETA ARAC1 ppa1 ARAC2 ppa2 sem-5 AGOS_AER202C Ptpn6 gefA gefB LOC479459 CDC42 BcDNA:GH28351 spry4 Mapk12 Mapk13 Pp4-19C Mapk14 piki-1 pik3ca PTPN11 ppp2r5ea 1279876 CDC55 ppp2r5eb pab1 NCU03786 ugt1a1 PTPN6 Mapk10 14-3-3zeta Mapk11 Dmel\CG17919 Ppp4r1 Dmel\CG17917 PPH22 csw MPK4 MPK5 PPP2R2A MPK6 MPK7 MPK1 MPK2 MPK3 Ppp2r2d Ppp2r2c Ppp2r2b PPP2R1B PPP2R1A SKP1 gefY mpkB ywhaba LOC_Os11g05470 FGF-18 v1g195622 PpV sty gefR bsk Rasa1 14-3-3epsilon Pi3K92E tws At1g22290 ppe1 sl Grap ppp4ca ppp4cb AgaP_AGAP011036 TRIADDRAFT_63380 3290548 BMH2 BMH1 Ppp2r2a pck1 pmk-2 pck2 pmk-1 Ppp2r1b Ppp2r1a 1281597 AgaP_AGAP012252 Grb2 GRAP ywhae1 ywhae2 Pik3c3 Os02g0224200 prkci B'ZETA prkcb Rac2 RAC2 racA RAC3 racC Rac1 RAC1 racB 1272934 HRAS rac1 DICPUDRAFT_98650 ywhag1 ywhag2 1269341 1269582 ras-1 Dmel\CG11597 NCU06544 Ppp2r5d Ppp2r5c rac-2 Map2k7 DAPPUDRAFT_301818 Map2k6 PPH3 Ppp2r5b Ppp2r5a PPP2CA PPP2CB SPBC26H8.05c ppp2cab ppp2caa ppp2cb MAP3K2 MAP3K3 MAP3K1 RAC6 RAC7 CBG05964 RAC4 RAC5 pphA 1279592 Os09g0284200 PPG1 Map2k4 Map2k3 Map2k2 Map2k1 Ppp2r5e DICPUDRAFT_53645 phr2aB ptpn11a GRF2 GRF3 GRF6 GRF5 GRF8 Hras ARAC11 1271515 GRF9 Mapk9 mig-2 cRac1A ppp6c Mapk8 EHI_181250 Mapk1 PEBP1 1282015 AgaP_AGAP011463 Mapk3 SIT4 rac1a rac1b mak-2 hep EHI_197840 AgaP_AGAP002748 v1g177129 Ras85D 1269396 vap pkc-1 rac1A rac1B EHI_070730 rac1C pkc-3 LOC521224 RAF1 Raf1 1274649 ppp4c MKK2 Mkk4 MPK10 MPK13 MPK14 MPK11 LOC_Os10g33680 B'DELTA 8036204 FGF20 Pik3cg Pik3cb tpa-1 Pik3cd FGF22 Pik3ca rad24 age-1 mapk10 rad25 FUS3 FGF17 TFL1 FGF16 Pbp2 FGF14 fgf13b PF3D7_0818200 FGF18 mapk12 FGF13 FGFR4 FGFR3 FGF12 FGFR2 FGF11 FGFR1 FGF10 YWHAE EHI_098280 Mtl par1 RasGAP1 YWHAB par2 CELE_Y69E1A.5 CrMPK2 Ywhaq FTT1 Ywhah Ywhag map2k4a plc-3 TMEM102 Ywhae fgf12a YWHAQ PPP2R5E Ywhab FHF-4 DICPUDRAFT_91511 Rasal1 DICPUDRAFT_76474 YWHAG YWHAH RASA4B PPP2R5B vps34 PPP2R5A PPP2R5D PPP2R5C PKC1 fttB YWHAZ fgfr1a RASA4 RASA1 RASA2 RFT1 DICPUDRAFT_47905 PF3D7_0925400 AgaP_AGAP000018 ANIA_04501 B'EPSILON Ywhaz Pi3K68D akt2 LOC_Os03g07150 TPD3 PHYPA_021214 B'THETA MAPK9 MAPK8 inaC rac3a rac3b Ptpn11 MAPK1 pptr-2 pptr-1 LOC298795 MAPK3 pppA SPRY4 Pebp4 Spry2 F40A3.3 kras Spry1 MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 ptp-2 PPP2R2C a5 AgaP_AGAP010273 PPP2R2B Spry4 PPP2R2D SPRY3 Pebp1 SPRY2 KRAS SPRY1 SNOG_03299 FLAVIN BIOSYNTHESIS%PANTHER PATHWAY%P02741 Flavin biosynthesis rib4 ribBA At2g20690 rib5 RIB1 FN0707 rib-5 Flad1 rib-4 rib-3 FAD1 FBgn0032522 FMN1 BT_2543 SCO1443 RIB5 NCU09371 RIB3 RIB4 BT_1317 SPBC23E6.06c FLAD1 anon-84Ea Rfk FHY RFK DR_0154 RIBA3 RIBA2 At2g44050 RIBA1 DR_1008 Dmel\CG4407 ribB ribA ribH NCU05983 CELE_R10H10.6 ribC SCO5711 ribF ribE TM_1827 urg1 TM_0857 rib1 fmn1 At5g03430 FORMYLTETRAHYDROFORMATE BIOSYNTHESIS%PANTHER PATHWAY%P02743 Formyltetrahydroformate biosynthesis tyms-1 DHFR2 pug HMT3 8026058 THY-1 MTR Mtr TM_0268 SCO2614 LmjF06.0860 CDC21 FN0163 At2g21550 dao-3 MHT1 FN1014 Ts Tyms Tb927.7.5480 purU1 purU2 mmuM FOLD4 FOLD3 FOLD2 dfr1 SPAC15E1.04 FOLD1 ybgG 1272582 SCO6137 PF3D7_0417200 MTHFD2 DR_0340 MTHFD2L TMP1 dfrA DFR1 Dmel\CG10621 FPGS3 FPGS2 thyA2 Nmdmc TM_0166 thyA1 HMT-1 TYMS HMT-2 Dmel\CG10623 folC Dhfr 1279701 folD DR_2632 LOC_Os10g35940 MTHFD1L purU tyms yitJ metH thyA Mthfd2 SCO1657 folA DHFR dhfr-1 DR_0966 Os01g0772900 metr-1 Os05g0150800 dhfr AgaP_AGAP008537 FRUCTOSE GALACTOSE METABOLISM%PANTHER PATHWAY%P02744 Fructose galactose metabolism GALT galE Ald1 Hex-A Aldob Aldoc Aldoa HK2 KHK HK1 Khk Gale GAL10 YLR446W Tb11.02.0330 Galt GAL7 Hkdc1 ALDP FBA1 FBA2 Hk2 Hk1 FBA6 galT GALE aldocb FBA7 FBA8 HXK2 HKDC1 Aldoart1 Aldoart2 ALD ALDOC ALDOB ALDOA PF14_0425 GABA-B_RECEPTOR_II_SIGNALING%PANTHER PATHWAY%P05731 GABA-B_receptor_II_signaling gnaia Kcnj3 gnb1b ADCY9 PRKAR1B PRKAR1A prkacaa Gnai1 Gnai3 prkacab prkar1b Gng10 Prkar1a Gnao1 Prkar1b GNAI3 CACNA1B ADCY4 CACNA1A ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 GNAI1 CACNA1G ADCY5 GNG3 Gng3 GNG5 Gng5 PRKAR2B Gng4 GNG4 GNG7 PRKAR2A Gng7 prkacbb GNG8 Gng8 KCNJ3 kin-2 GABBR2 Gngt2 GABBR1 gng3 Prkar2a Prkar2b GNG11 GNAO1 GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb3 GNB3 Gng11 Cacna1g gnb1 Cacna1a Cacna1b gnb2 pkaC GNGT2 Gabbr1 prkar1ab PRKACG Gabbr2 Adcy4 gnai3 Adcy1 prkar1aa Adcy2 PRKACA Adcy7 gnai1 Adcy8 PRKACB Adcy5 Adcy6 Adcy9 Prkx Prkaca Prkacb GAMMA-AMINOBUTYRIC ACID SYNTHESIS%PANTHER PATHWAY%P04384 Gamma-aminobutyric acid synthesis gad1b UGA2 UGA1 DR_A0003 Aldh5a1 GADL1 ABAT gad CSAD gabD Gabat 1276534 Csad ALDH5F1 SCO7035 gatA gad2 gta-1 SPAC139.05 1270119 Ssadh b unc-25 davD GAD1 Gad1 GATA GAD2 Gad2 Abat GAD67 Dmel\CG5618 ALDH5A1 uga1 NCU08998 NCU00936 1273535 abat 1273834 GBB_SIGNALING_PATHWAY%PANTHER PATHWAY%P06214 GBB_signaling_pathway Smurf sax Med Pdp tkv put alph Fur1 Mad nej wit gbb GENERAL TRANSCRIPTION REGULATION%PANTHER PATHWAY%P00023 General transcription regulation rpb-5 Brf Taf8 TAF8 Os01g0510800 Taf7 TAF7 TAF6 Taf6 rpb3 BRAFLDRAFT_118777 TAF4 Taf4 NCU02615 Taf2 TAF2 Gtf2a1l TFB4 PBRP2 TFB2 GTF2B PBRP1 TTF1 Ttf1 fcp1 1274077 8034249 F14P3.19 tbpl1 Gtf2f2 Gtf2f1 LOC100912534 1274516 tfbF NRPB5A tfbD polr2ea tfbB TFA2 tfbC tfbA TfIIFbeta cfap20 1279496 BRP4 GTF2F1 gtf-2e1 GTF2F2 gtf-2e2 tfb AgaP_AGAP010493 tfb2 Gtf2b tfb1 TBPL1 Gtf2e1 Gtf2e2 mia At5g15570 Taf1c gtf-2A2 NRPB3 Bug22 GTF2E1 GTF2E2 sa Taf9b NRPB4 Gtf2h1 Gtf2h4 Gtf2h3 GTF2A1L DAPPUDRAFT_308488 AgaP_AGAP005731 MTERF2 MNC17.14 tcf-29 TfIIEalpha 1276961 1278625 At3g09360 At3g16680 DAPPUDRAFT_304965 brf1a brf1b NRPB5L1 v1g190658 Taf7l taf7 STON1 taf8 taf6 taf-7.2 TfIIA-L taf2 gtf2h3 TFIIB2 TFIIB1 taf-8 Taf11 polr2f TDS4 polr2h Taf12 toa2 TFG2 polr2c NCU01515 RpII18 TfIIEbeta toa1 ttb-1 TfIIB brf-1 At1g07470 NRPD5B gtf2b Tbpl1 tfg2 NCU07289 1280317 Cfap20 Gtf2a1 TFIIB Gtf2a2 TfIIA-S-2 NCU05305 TFIIAy NCU09748 TAF6B TfIIFalpha e(y)1 gtf2a2 GTF2A1 GTF2A2 TAF9 Taf9 Mterf1 RPB3 Rpb3 Polr2h Polr2e 1279068 Polr2f B0336.13 PSMC3IP At2g45100 Rpb8 RPB6 TAF1C tfa2 POLR2C NCU04523 Rpb5 POLR2E POLR2F POLR2H TAF9B CFAP20 SUA7 rpb8 NCU08030 BRF2 Brf2 TAF12 BRF1 rpb5 Brf1 rpb4 NRPE5C NRPE5A TAF11 BATDEDRAFT_32931 GTF2H1 PF3D7_0205500 TOA2 TOA1 GTF2H3 GTF2H4 sua7 1276084 1273770 brf2 Mterf1a Mterf1b brf1 1271351 rpb-8 GENERAL TRANSCRIPTION BY RNA POLYMERASE I%PANTHER PATHWAY%P00022 General transcription by RNA polymerase I LMJF_19_1390 tbpC2 RPC19 tbp2 tlf-1 tbp3 taf8 tbpA Trf TTF1 Ttf1 Trf2 polr2k F14P3.19 taf-8 Cavin1 tbpl1 UBTF tbpl2 tbp1 1271006 rpa2 rpac-19 TBP Tbp Polr1b Tbpl2 NCU04770 Tbpl1 Polr1d acr-2 TBPL2 POLR1B rpc19 POLR1D TBPL1 polr1b tbp RRN3 RPA135 At5g15570 EHI_112050 Taf1c Taf1b SPT15 sa PSMC3IP rpoa-2 TAF1B TAF1C TAF1A POLR2K CAVIN1 tbpB4 NRPA2 rrn3 RpI135 tbpF tbpE tbp-1 Ubtf TBP2 Taf8 TAF8 GLUTAMINE GLUTAMATE CONVERSION%PANTHER PATHWAY%P02745 Glutamine glutamate conversion puuA glnA NCU04264 Gdh Lgsn BT_0785 BT_0543 1274510 SCO4683 gln1 FN0488 GLUL glnA4 glnA2 glnA3 glnA1 PA5508 gdh PF3D7_1416500 NCU02479 LGSN glnA-2 glnA-3 PAE3438 CHLRE_12g530600v5 gdhA Glud1 gdhB DR_2033 gln-6 gln-5 gln-2 gln-3 SCO6961 SCO6962 SS1G_09120 gln-1 gdh1 SCO2241 PAE2556 PA3356 1275909 PA5522 1273608 GLN2 GLN1 SCO1932 At1g51720 glud1b glud1a GLUD1 GLUD2 rocG 1279950 glulb PAE1996 PA1566 glula Glul gll2499 PA2040 fluG GLN1-5 GLN1-3 GLN1-2 GLN1-1 GL50803_0021942 gdhA1 glud1 spuI Gs1 gdhA2 GDH2 GDH1 Gs2 GDH3 Os01g0558200 NodGS SCO2210 DR_0980 DR_1718 spuB gln-2.1 gln-2.2 PAE3442 BT_1973 gdh-1 DR_0451 glnII gdhA-3 blr2084 gdhA-4 SCO1613 gdhA-1 gdhA-2 GSH3 BT_4339 bb8 gudB GLYCOLYSIS%PANTHER PATHWAY%P00024 Glycolysis Gpi GPI GAPC1 Gapdh1 LOC_Os10g42100 Eno1 ENO1 Gapdh2 LOC100014733 GPM1 ENO2 Eno2 HK2 GPM3 GPM2 HK1 pgi2 Pgam2 pfkA Pgam1 gapA gpd-1 pgk-1 TPI1 Tpi1 PGAM2 Hkdc1 BPGM pgi1 Gapdh ERR2 gpmA ERR3 LOC100031601 PKM Pkm PGK HKDC1 PKP2 1275659 PKP1 PGAM4 ALDOB PKP3 ALDOA gpm1 GAPDH Os03g0776000 GAPA1 tpiA Pklr Ald1 Hex-A Bpgm Tpi Aldoa Pfkl pgk PGK1 Pgk1 PGK3 pfkA2 Pfkm PKLR eno Os06g0256500 pgk2 Hk2 Hk1 PFKL aldocb eno1a Aldoart1 SCO7040 Aldoart2 ALD PFKM UNTITLED%PANTHER PATHWAY%P06664 untitled Atf2 Eif2ak3 Elk1 Gpld1 Prkaa1 Akt1 Prkcq Isl1 Prkcb Prkcd Prkce Prkca Gata4 Gata2 Atf3 Jund Insr Lhb Gnrh1 Pknox1 Gucy1b1 Gucy1b2 Ar Tcf7l1 Prkcz Egr1 Jun Bmpr1a Bmpr1b Mtco2 Ptk2 Pbx1 Crebbp Grb2 Junb Pla2g4c Pea15 Fshb Gnrhr Pla2g4a Plcb1 Esrra Pou2f1 Sdf4 Adcy1 Rac1 Ascl1 Rap1b Mmp14 Fos Ppara Pparg Zeb1 Gnai2 Gnai1 Pik3r1 Nr4a1 Gnai3 Nfyb Nfya Nfyc Prkar1b Ep300 Map2k7 Map2k6 RELA Adipor2 Adipor1 Dusp1 Fosb Inha Pla2g6 Kat2b Map2k4 Map2k3 Map2k2 Map2k1 Stat3 Map3k10 Map3k11 Map3k12 Nr5a1 Map3k13 Hras Map3k14 Mapk9 Cacna1f Mapk8 Cacna1c Tuba1b Irs1 Tuba1a Cacna1d Tuba1c Irs4 Mapk1 Map3k9 Irs2 Irs3 Map3k8 Ctnnb1 Map3k7 Map3k5 Prlr Mapk3 Map3k4 Cacna1s Fst Egfr Map3k3 Map3k2 Pcp4 Map3k1 Anxa5 Pgr Raf1 Vcl Nr3c1 Tcf7 Gnao1 Pxn Npr2 Map4k5 Map4k4 Map4k3 Snrpn Tgfb1 Tgfb2 Sp1 Crtc1 Itga1 Gnaq Gnas Amhr2 Otx1 Drd2 SKIL Prkag1 Prkag2 Ppp3ca Syt4 Cav1 Map4k2 Smad1 Map4k1 Smad2 Smad3 Lhx2 Dgkz Smad4 Gnb2 Gnb1 Smad9 Gnb4 Gnb3 Inhba Gnb5 Inhbb Smad5 Ldb1 Alox15 Ybx3 Nfatc4 Slc2a1 Nos1 Nfatc1 Nfatc3 Nfatc2 Creb1 TGIF1 Ksr1 Dnm1 Itgb1 Sos2 Sos1 Gna11 Src Srf Camk2b Gng2 Acvr1b Arhgap32 Cdc42 Mapk12 Mapk13 Mapk14 Tgfbr3 Ptk2b Pitx1 Eif2a Pitx2 Bmpr2 Prkab2 Acvr2a Htr3a Acvr2b Prkab1 Mapk11 HEDGEHOG SIGNALING PATHWAY%PANTHER PATHWAY%P00025 Hedgehog signaling pathway hh GSK3B GSK3A cos ptch1 sap18 GLI1 Gli1 mcb GLI3 Gli3 At2g45640 csnk1a1 SHH prkar1ab BRAFLDRAFT_84974 SUFU gsk3ba prkar1aa BTRC gsk3bb ptc-1 FBXW11 CSNK1E Fbxw11 C16C10.4 Gsk3b CBG07560 Pka-R1 Su(fu) Pka-R2 Smo PRKAR1B SMO PRKAR1A Bin1 1281176 AgaP_AGAP001944 shha Btrc gli1 Csnk1e gli3 prkar1b DAPPUDRAFT_301140 Prkar1a Prkar1b Csnk1a1 C44H4.6 gli2a fu dco smo PRKAR2B Ptch1 STK36 PRKAR2A UBR5 Ubr5 SAP18 v1g161273 RGD1561590 ptc AgaP_AGAP004940 kin-2 CREBBP CSNK1A1 Prkar2a PTCH1 Prkar2b ubr5 ci fbxw11b Crebbp hyd Sufu pkaR CkIalpha CSNK1A1L HEME BIOSYNTHESIS%PANTHER PATHWAY%P02746 Heme biosynthesis l(3)02640 hemB hemC HEM15 cgoX hemD urod hemE HEM13 hemF HEM12 hemH HEMB1 CPOX cox10 hemL Os01g0185200 gluQ GlnRS hem2 hem3 Hmbs FC2 UROD nasF Cpox CPX2 CPX1 OVA9 FN0644 ctaB OVA3 EARS2 LA_4200 mgluS At5g26710 uroD MDC12.26 Cpx1 RSAD1 SCO1553 DR_2160 Ears2 Ppox 1273396 NCU01546 MA_3033 Os01g0271200 HMBS HEMB2 LA_4218 gltX 1271017 cox-10 Qars1 FECH DR_0130 hemN_1 fech GluRS-m 8032882 Coprox FN0460 Pbgs COX10 sumT HEM3 HEM2 Eprs1 HEME2 GLN4 NCU02771 HEME1 LOC_Os10g22380 Eprs Cox10 EPRS1 hemW UPM1 PPT1 glnS Urod cyoE FeCh GUS1 ALAD FN0560 QARS1 ctaB1 MSE1 gltX1 Os01g0527700 gltX2 PA0386 SSO0181 mse1 ears-1 TM_1166 Fech cobA DR_A0011 GluProRS ears-2 cyoE2 cyoE1 1279691 Alad PHYPA_016093 hemC2 1271452 hemC1 SPCC1739.06c cobJ gus1 PF3D7_1440300 qrs1 SCO2559 PPOX MET1 Rsad1 GSA qars-1 hem12 hem13 AgaP_AGAP008884 NCU00602 GSA2 hem15 GSA1 gsaB cpfC ctaB2 Os05g0361200 PAE0583 1273018 Dmel\CG5037 SPCC417.11c HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GI ALPHA AND GS ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00026 Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway Adora2b gnai2b Adora2a BRAFLDRAFT_124869 Htr4 HTR4 HTR6 LOC694289 Htr6 HTR7 Htr7 5-HT7 CREB3L3 prkar1ab CREB3L4 PRKACG CREB3L1 CREB3L2 gsk3ba Phka1 prkar1aa Phka2 PRKACA PRKACB PHKA1 PHKA2 ADCY9 PRKAR1B PRKAR1A C14B9.8 CGNRH-R rap1ab rap1aa rap1b PRKAR2B PRKAR2A CREBBP BRAFLDRAFT_87235 AstC-R1 Chc PYGB CLTC CLTB SNX13 CLTA PYGM PYGL Dop1R1 Dop1R2 Clta Cltb Adcy3 Cltc Adcy4 Adcy1 Adcy2 Adcy7 Adcy8 Adcy5 Adcy6 Mtnr1a Adcy9 SS1G_03482 prkacaa adra2a adra2b adra2c prkacab Prkar1a Prkar1b v1g88970 ADCY4 Ep300 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PHYPA_018206 Pygb Prkar2a Prkar2b Pygl Pygm GPR50 Dhit cbp-1 cbp-3 Gpr50 Snx13 Clc CHRM2 CHRM3 CHRM1 sstr2a CHRM4 mgl-1 CHRM5 ADORA3 ADORA1 DICPUDRAFT_93216 Ac13E DICPUDRAFT_45258 Kcnj3 MTNR1A MTNR1B mAChR-B mAChR-A prkar1b 4576002 CREM Phkb gsto1 RAP1B Chrm1 Chrm3 Gbeta76C Chrm2 RAP1A Chrm5 LMJF_09_0910 Chrm4 CLTCL1 Crem AdoR DRD1 Drd1 DRD2 Drd2 DRD3 Drd3 DRD4 Drd4 Drd5 DRD5 HTR1E HTR1F sstr1a HTR1D HTR1A GPR5HT1A HTR1B GPR5HT1B PHKB drd5 11217 PGTG_11337 rgs-1 CAM1-3 oprm1 TRIADDRAFT_37105 HTR2B HTR2C ADRA1D HTR2A ADRA1B ADRA1A Htr2a Htr2c Htr2b UMAG_03910 sfaD GNRHR2 Phkg1 Phkg2 ADRA2C ADRA2B ADRA2A Htr1d ADORA2A CBG16677 ADORA2B Htr1f Tb10.70.0830 Htr1b Htr1a AgaP_AGAP010957 oprk1 Kcnj9 Kcnj6 Kcnj5 PHKG1 PHKG2 KCNJ3 KCNJ5 KCNJ6 KCNJ9 HTR5A GPRMAC1 cmd-1 v1g187791 acy-1 mGluR Oprd1 calA HAC12 rgs7a gpb-1 v1g239788 Sstr5 Sstr4 Sstr3 gnb1b Sstr2 Sstr1 BRAFLDRAFT_60318 Htr5b Htr5a CALM Gng10 Calm3 Calm1 creb3l3l GNG10 CG7766 BRAFLDRAFT_220697 Gngt1 Gngt2 1269400 GNG12 GNG13 Crebbp CAM7 CALM1 CAM2 Gng12 Gng13 Gnrhr GNGT1 GYS2 GYS1 Gys1 Gys2 GNGT2 git5 STE4 GNRHR 1272931 Rap1a PHYPA_013668 Rap1b oprd1a AkhR ADRB3 GPRDOP1 GB1 Gnai2 Gnai1 Adrbk2 Gnai3 OPRD1 CND03830 GNAI3 GNAI1 GNAI2 grk1a GPRADS gnb-1 RSG7 gpbA Adra2a Adra2c Adra2b gnb1 gnb2 Rgs4 RGS4 RGS5 Rgs5 RGS2 Rgs2 Rgs3 RGS3 RGS1 Rgs1 AgaP_AGAP009278 EP300 gnai3 Oprl1 RGS8 Adrb2 Rgs8 gnai1 RGS9 Adrb1 Rgs9 RGS6 Rgs6 RGS7 Rgs7 Adra1b Adrb3 Adra1a Adra1d HAC1 HAC2 HAC5 HAC4 gnaia Oprm1 1273314 Creb3l3 Creb3l4 ADRB1 Creb3l1 ADRB2 Creb3l2 chcA Grk1 GRK1 Hrh1 HRH1 GRK3 Grk2 Gnal GRK2 GRK5 HRH3 8035476 Grk5 Hrh4 GRK4 Grk4 HRH2 GRK7 Hrh2 HRH4 Hrh3 GRK6 Grk6 calm3b prkacbb chc-1 grk3 CG8475 BRAFLDRAFT_59748 CHC2 CHC1 cltca Gpsm2 Gprk1 GNAL Gpsm1 Adora1 GNB2 Gnb2 GNB1 Gnb1 Adora3 chc1 GPSM1 GSK3B GPSM2 GSK3A Grm1 GRM1 GRM3 Grm3 GRM2 Grm2 GRM5 Grm5 GRM4 Grm4 Grm7 GRM7 Grm6 GRM6 GRM8 Grm8 1271449 Creb1 Creb3 gar-3 Prkaca OPRM1 SSTR1 Prkacb Creb5 SSTR2 SSTR3 SSTR4 CAM Cam SSTR5 Gsk3b CrebA CREB3 CrebB CREB1 Gsk3a Octbeta1R CREB5 RGS18 RGS17 RGS19 RGS14 RGS13 RGS16 Rgs20 OPRL1 Rgs17 drd1a drd1b Rgs18 Rgs19 GNG3 Gng3 GNG2 Gng2 GNG5 Gng5 GNG4 Rgs14 Gng4 GNG7 Gng7 Rgs16 5-HT1A RGS20 GNG8 Gng8 5-HT1B gng2 gng3 OPRK1 Rgs10 Rgs11 Rgs12 PhKgamma RGS10 RGS12 Oprk1 RGS11 5-HT2A HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-GQ ALPHA AND GO ALPHA MEDIATED PATHWAY%PANTHER PATHWAY%P00027 Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway Gnb4 Adora3 Gnb3 GNB3 chc1 Itpr3 Itpr2 Itpr1 GPSM1 GPSM2 gngt2a oprm1 Grm1 GRM1 GRM3 Grm3 GRM2 Grm2 GRM5 Grm5 GRM4 Grm4 Grm7 GRM7 Grm6 GRM6 GRM8 Grm8 BDKRB2 BDKRB1 1271449 sfaD GNRHR2 gar-3 OPRM1 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 ADORA2A ADORA2B Tb10.70.0830 RGS18 RGS17 Gna11 RGS19 RGS14 RGS13 Gna15 RGS16 Gna14 oprk1 Rgs20 OPRL1 Kcnj9 Kcnj6 Kcnj5 Rgs17 drd1a GNA14 drd1b Rgs18 Rgs19 GNA15 GNG3 Gng3 GNG2 Gng2 GNG5 Gng5 GNG4 Rgs14 Gng4 GNG7 GNA11 Gng7 Rgs16 RGS20 GNG8 Gng8 KCNJ3 KCNJ5 KCNJ6 gng2 gng3 KCNJ9 gng7 OPRK1 Rgs10 Rgs11 Rgs12 GPRMAC1 RGS10 v1g187791 RGS12 Oprk1 RGS11 Adora2b Adora2a mGluR Oprd1 rgs7a PRKCG PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD PRKCA Prkcq Sstr5 Prkcg Sstr4 Sstr3 gnb1b Prkch Prkci Sstr2 Prkcb Sstr1 Prkcd Prkce Rasgrp3 Rasgrp4 PRKCQ Rasgrp1 Rasgrp2 Prkca CGNRH-R rap1ab rap1aa Gng10 rap1b Arhgef1 PRKCZ GNG10 gna11b BRAFLDRAFT_220697 Prkcz Gngt1 Gngt2 1269400 GNG12 GNG13 Gng12 Gng13 AstC-R1 Chc Plcb4 Plcb3 CLTC CLTB CLTA Gnrhr Rhoa Plcb2 Plcb1 GNGT1 prkci Dop1R1 GNGT2 git5 Dop1R2 Clta STE4 prkcb Cltb GNRHR Cltc 1272931 GARNL3 Rap1a Rap1b oprd1a rhoad AkhR rhoab RHOA SS1G_03482 rhoaa PLCB3 PLCB4 GPRDOP1 GB1 ARHGEF1 Adrbk2 PLCB1 PLCB2 OPRD1 CND03830 GPR45 Garnl3 Dnajc27 GPRADS Gpr45 BRAFLDRAFT_209131 gnb-1 Dhit cRhoA RSG7 gpbA Clc CHRM2 CHRM3 Rap1gap Cacna1e CHRM1 sstr2a Cacna1a CHRM4 mgl-1 gnb1 Cacna1b CHRM5 gnb2 Rgs4 RGS4 RGS5 Rgs5 RGS2 Rgs2 Rgs3 RGS3 RGS1 Rgs1 ADORA3 ADORA1 DICPUDRAFT_93216 Oprl1 RGS8 Rgs8 RGS9 Rgs9 RGS6 Rgs6 RGS7 Rgs7 DICPUDRAFT_45258 Kcnj3 Oprm1 mAChR-B mAChR-A Gnao1 ITPR1 CACNA1B ITPR2 CACNA1A Bdkrb2 ITPR3 Bdkrb1 RASGRP2 RASGRP1 DNAJC27 CACNA1E chcA RAP1GAP RASGRP4 RASGRP3 RAP1B Chrm1 GRK3 Chrm3 Gbeta76C Grk2 GRK2 Chrm2 RAP1A GRK5 8035476 Grk5 Chrm5 GRK4 Grk4 Chrm4 GRK7 Gnaq Ggamma1 CLTCL1 GRK6 Grk6 AdoR DRD1 Drd1 DRD2 Drd2 DRD3 Drd3 DRD4 Drd4 Drd5 DRD5 chc-1 grk3 sstr1a gnaq CHC2 CHC1 cltca GNAO1 drd5 Gpsm2 Gprk1 Gpsm1 rgs-1 Adora1 GNAQ GNB2 Gnb2 GNB1 Gnb1 GNB4 HETEROTRIMERIC G-PROTEIN SIGNALING PATHWAY-ROD OUTER SEGMENT PHOTOTRANSDUCTION%PANTHER PATHWAY%P00028 Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction gnb1 BRAFLDRAFT_124869 gnb2 CALML3 Pde6g PRKACG DICPUDRAFT_93216 GNAT1 PRKACA calA PRKACB RGS9 Rgs9 gpb-1 v1g239788 gnb1b ZNF319 CALM Pka-C1 Gng10 Calm3 Calm1 Grk1 GRK1 Gbeta76C GNG10 8035476 LMJF_09_0910 calm3b BRAFLDRAFT_220697 prkacbb kin-1 Gngt1 Gngt2 grk-2 ninaE BRAFLDRAFT_59748 GNG12 GNG13 11217 Gprk1 PGTG_11337 BRAFLDRAFT_87235 GNB2 Gnb2 GNB1 Gnb1 CAM7 GNB4 Gnb4 GNB5 Gnb5 CALM1 CAM2 Gng12 v1g188289 Gng13 11175546 gngt2a CAM1-3 TRIADDRAFT_37105 GNGT1 CBG14305 git5 GNGT2 STE4 CNGA1 CNGA3 Rh2 BRAFLDRAFT_57361 Rh6 sfaD PHYPA_013668 UMAG_03910 Cngb1 Prkaca Prkacb DAPPUDRAFT_319998 Cngb3 Cam SS1G_03482 CAM GB1 prkacaa gnb5a CNGB3 CNGB1 prkacab AgaP_AGAP010957 CND03830 v1g88970 gnat1 Cnga3 pde6gb PDC Pdc Cnga1 grk1a GNG3 Gng3 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 Gng7 RHO Rho Calml3 GNG8 Gng8 PDE6B PDE6A PHYPA_018206 gnb-1 RCVRN gng2 gng3 PDE6G gng7 Pde6a Pde6b Gnat1 F47F2.1 GPROP1 Rcvrn cmd-1 1281793 gpbA rho GPROP7 GPROP6 GPROP5 HISTAMINE H1 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04385 Histamine H1 receptor mediated signaling pathway GNG2 Gng2 GNG5 Plcl2 Gng5 Plcl1 Gng4 GNG4 GNG7 GNA11 Gng7 inaC GNG8 Gng8 1270776 gnb-1 gng2 Gbeta5 gng3 gng5 PLCL1 plc gng7 PLCL2 Plce1 gnb3b gnb3a gpbA PLCD3 PLCD4 PLCD1 gnb1 gnb2 prkcbb prkcba AgaP_AGAP002748 PLCE1 DICPUDRAFT_93216 Plc21C plc1 PRKCG norpA gpb-2 PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD Plcg1 Pkcdelta PRKCA Pkc53E Plcg2 Prkcq pkc-1 Prkcg pkc-2 Prkch Gbeta13F gnb1b pkc-3 Prkci Prkcb Prkcd egl-30 Prkce PRKCQ Prkca prkcda Gng10 ITPR1 Plch1 ITPR2 ITPR3 PRKCZ Hrh1 HRH1 Gbeta76C GNG10 8035476 gna11b Gnaq BRAFLDRAFT_220697 PLCG2 1281188 sl PLCG1 Prkcz Galphaq tpa-1 Gngt2 gnaq PLC4 PLC3 PLC5 GNG12 PLC2 PLC1 PLC8 itr-1 PLC7 GNB2 Gnb2 GNAQ AgaP_AGAP012252 GNB1 Gnb1 PLC9 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 Itpr3 Gng12 Itpr2 Itpr1 Plcb4 Plcb3 Gnaq1 gngt2a AgaP_AGAP006475 prkcq aPKC egl-8 plcg1 Plcb2 Plcb1 plc-2 prkci plc-3 1276578 plc-4 1276579 git5 GNGT2 PLCZ1 STE4 prkcb plc-1 itpr1 AgaP_AGAP009115 Os07g0694000 sfaD 1276580 SS1G_03482 Itpr PLCB3 PLCB4 gnb5b GB1 gnb5a PLCB1 PLCB2 Gna11 prkchb CND03830 Gna14 Pkc98E Plcd1 Plcd4 GNA14 GNG3 Gng3 1281667 HISTAMINE H2 RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04386 Histamine H2 receptor mediated signaling pathway Gngt2 gnal GNG12 GNAL GNB2 Gnb2 GNB1 Gnb1 GNB4 Gnb4 GNAS Gnb3 GNB3 GNB5 Gnb5 Gng12 AgaP_AGAP008039 gngt2a 1276578 1276579 git5 GNGT2 STE4 Adcy2 Adcy7 sfaD 1276580 Prkaca Prkacb DAPPUDRAFT_319998 SS1G_03482 gnb5b GB1 gsa-1 prkacaa gnb5a prkacab CND03830 ADCY2 PRKX ADCY7 LmPKAC2b GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 prkar2ab Gng4 GNG4 GNG7 Gng7 GNG8 Gng8 AgaP_AGAP004940 gnb-1 gng2 Gbeta5 gng3 Prkar2a gng5 Prkar2b gng7 LOC112204126 gnb3b gnb3a 1281793 gpbA gnb1 gnb2 pkaC LOC694289 PRKACG DICPUDRAFT_93216 PRKACA PRKACB gpb-2 gpb-1 pkac1 Prkx Gbeta13F gnb1b LMJF_35_3960 Pka-R2 1277119 Pka-C1 Pka-C3 Gng10 Galphaf Gbeta76C GNG10 Gnal 8035476 PRKAR2B HRH2 PRKAR2A Hrh2 BRAFLDRAFT_220697 prkacbb Gnas prkacba Galphas kin-1 HISTAMINE SYNTHESIS%PANTHER PATHWAY%P04387 Histamine synthesis HDC Hdc AgaP_AGAP009001 HISTIDINE BIOSYNTHESIS%PANTHER PATHWAY%P02747 Histidine biosynthesis hisK hisC1 hisC2 his2 his3 his-6 his4 his-3 Rv2231c his5 SPCC1672.01 his7 BT_1478 his-2 HIS1 PAE0958 SCO1859 HIS3 HIS2 pat HIS5 HIS4 65E11.030 HIS7 hisC-like BT_4257 Os02g0709200 HISN6A his1 NCU06974 FN0973 PA2531 HISN5A hisB hisC HISN5B HISN4 hisD hisE hisF HISN1A hisG HISN1B HISN8 hisH hisI HUNTINGTON DISEASE%PANTHER PATHWAY%P00029 Huntington disease LOC100020439 act18 actr2b DNAH3 arx-2 arx-3 DNAH1 tbp DNAH7 arl4a EHI_112050 DNAH8 DCTN1 DNAH5 arl4c arx-1 Dmel\CG9068 MAPK9 Dhc16F BATDEDRAFT_36333 rac3a act23 BRAFLDRAFT_56698 rac3b act22 ANIA_01126 1272315 zgc:65894 1269175 WBGene00098673 Casp8 Actc1 Actbl2 Dlic che-3 unc-26 Casp3 Casp6 LOC101906513 Act87E Ci-LC6 dhcA BRAFLDRAFT_130244 CAPN11 dhc-1 ACTC1 CAPN12 CAPN10 Dnah5 Dnah8 At3g16120 BRAFLDRAFT_56687 Tnfaip8 Dnah7 BRAFLDRAFT_120208 TAF4 Taf4 GAP1a|GAP1b CYFIP2 CYFIP1 arcA v1g245773 gapdh ARPC5L akt3b PF3D7_1034700 CAPNS1 Dctn1 CAPNS2 AKT2 Akt3 Akt2 AKT3 Akt1 AKT1 dynll1 EHI_129750 gapA nda3 gapB BRAFLDRAFT_126918 GAP3 tra-3 Optn Acta1 Acta2 tubb2b PF10_0084 SS1G_08733 AgaP_AGAP011730 gap1 gap2 1273032 BRAFLDRAFT_114958 DYNC1LI1 DYNC1LI2 arc1 act-2 act-1 DICPUDRAFT_48914 act-4 act-3 OPTN FN0652 act-5 BRAFLDRAFT_79607 TVAG_090470 BRAFLDRAFT_122664 v1g242285 GL50803_007789 Tb927.8.1890 8036844 arf1 Dhc36C GRIN2A SNOG_06879 ARFA1A WBGene00099845 nudA nudG CREBBP JUN Jun FLA14 grik1b betaTub56D BC048507 UMAG_00387 BRAFLDRAFT_263946 GL50803_006687 GRIN2C GRIN2B GAPB LMJF_07_0060 ARFA1F GRIN2D TVAG_412780 ACT GRIN3A Act Os12g0163700 GPD DICPUDRAFT_46519 gapdh-2 tubb4b ARF3 Arf4 ARF4 Arf3 ARF1 Arf2 ARF2 Arf1 CBG00820 ARPC1B tbp2 ARPC1A tbp3 CLTB CLTA tbpA v1g229095 Cyt-c1 ptgfr 1270190 ARFD1A SCO7511 1270194 act ro-1 Clta ro-3 Cltb Tb09.211.0620 tbp1 DYL1 8030084 ARF2-B Os08g0248900 arfA arl4cb clp-2 arl4ca BRAFLDRAFT_125401 FOS Fos DYNLL1 arf6 DYNLL2 LOC106558132 ARFD1B ap2a1-2 CYC1-1 actin TUBB2B arl-1 TUBB2A CYC1-2 DAPPUDRAFT_305638 Hap1 anon-WO0140519.132 cyc-1 HAP1 LOC100029767 Act57B ARF5 PGTG_05488 Arf6 ARF6 Arf5 CHLRE_12g484250v5 Rop3 TRIADDRAFT_49626 Ep300 Htt HTT arl-8 AgaP_AGAP010435 Os05g0106600 TVAG_008680 UMAG_11232 AP-2alpha DYN1 DYN2 LOC_Os03g59740 Os07g0223100 PFL2215w SS1G_06730 TBP1 TUBB4B TUBB4A WBGene00273840 1274462 cyfip1 tbpF CYIIIB cyfip2 CYIIIA BRAFLDRAFT_114976 cbp-1 tbpE cbp-3 Arfip2 TBP2 DAPPUDRAFT_231341 DICPUDRAFT_90232 Tubb4b Clc Tubb4a AgaP_AGAP009568 v1g188243 AGOS_ACR225C TVAG_337240 TUBB8 map3k14b 1281844 TUBB7 TUBB6 TUBB5 PHYPA_005833 TUBB4 TUBB3 LOC100176797 TUBB2 TUBB1 acnA 37852 v1g169611 arl1 BRAFLDRAFT_58093 cyt1 TUBB9 MAP2K4 TRIADDRAFT_63686 Tubb2b Tubb2a ced-10 NCU03440 v1g234494 BRAFLDRAFT_124235 v1g236679 T17J13.250 ALPHA-ADR SNOG_01139 DAPPUDRAFT_300544 nmr-1 DAPPUDRAFT_302845 GAPDHS benA sek-1 actg1 ARAC3 ARAC4 ARAC9 ARAC7 GAPA2 GAPA1 TVAG_475220 LOC100185123 Arl4 PHYPA_011051 ARL1 cyt-1 Arl1 arf-1.2 arf-1.1 Dync1li2 CYT1 SPT15 OJ1528D07.7 Dync1li1 8026073 ARL17A 1281502 BRAFLDRAFT_116948 bdnf Sp1 Dhc64C Dhc93AB 1271943 MAP2K7 EHI_073470 Act5C Tubb5 LOC750209 Tubb6 Tubb3 BDNF Tubb1 Os01g0256400 ARPC5 Os05g0301700 8029221 SYNJ1 capn1 SP1 casp3a BRAFLDRAFT_114535 DAPPUDRAFT_302823 Arpc5 MAP3K10 SP8 GAPC3 GAPC2 GAPC1 Bdnf CBG02167 acta2 v1g242065 SS1G_07798 BRAFLDRAFT_126324 Trf arf6b CBG02162 CBG02161 ACT1B taf-4 ACT1A 1278999 IscW_ISCW024111 Dhc98D Dhc62B ACT1C BRAFLDRAFT_114344 apl3 ACT12 ACTR2 CG32396 GAPD1 APAF1 Dmel\CG8407 Gapdh ARL4C ARL4D Os04g0459500 ARL4A TVAG_054030 ACTBL2 PHYPA_023183 BRAFLDRAFT_115565 BRAFLDRAFT_115566 GAPDH LOC100028958 TVAG_034440 v1g167737 actc2 ARAC1 ARAC2 actc1 TRIADDRAFT_19810 PHYPA_003231 APL3 act9 act3 CDC42 si:dkey-183j2.10 actba actbb KBP Cdc42 ADP-ribosylation Act1 ACT1 Arl4a Arl4d Arl4c tbpB4 HIP1R LOC100016601 PHYPA_006512 ACT2A act1 WBGene00092447 1279875 v1g166872 Capns1 Capns2 Capn10 nht pirA casp8 Capn12 tub-2 arf2a PA4429 dlc-1 ACTB GAPCP2 tp63 GAPCP1 ANIA_07487 ARFIP2 ACT9 Act7 ACT7 Act5 Tb09.211.4460 ACT4 PGTG_00026 Tp53 ACT5 TP63 HAC12 ctp ACT2 ACT3 DYNC2H1 Sra-1 LMJF_33_0792 CalpA EHI_107290 arf3b LOC735377 tp53 fbcH slpr Actb Arf79F Arpc1b Actr2 TVAG_146910 Arpc1a 35269 ARF Apaf1 1281696 Hip1r GL50803_0040817 Kalrn TP53 actb Tb09.211.4470 Grin2a TRIADDRAFT_63375 LMJF_08_1230 Cbr-gpd-1 KALRN IDA5 Tub6 tubC Tub4 Tub3 Tub2 TUB2 tubB Tub1 TUB1 gpd-4 gpd-3 Tp73 LOC100092493 gpd-2 Grin3b Grin3a SNOG_12991 TVAG_347410 LOC100079040 DKEY-238C7.11 TVAG_512800 DICPUDRAFT_47166 tp73 Crebbp WBGene00094945 Grik5 tbp-1 Os01g0935700 1281597 Cyfip2 Cyfip1 Grik2 Grik1 Grik4 Grik3 Grin2d Tp63 Grin2c TP73 Grin2b Caur_3729 HIP1 GRIK5 TRIADDRAFT_63238 GRIK3 Rhog GRIK4 GRIK1 AP2A1 GRIK2 WASL AP2A2 Dync1h1 zgc:55461 LOC_Os10g42940 ALPHAC-AD BRAFLDRAFT_127490 cdc-42 Rhoj Rac2 RAC2 racA dlc2 RAC3 mec-7 racC Rac1 RAC1 racB WBGene00111311 Rhoq RAB8A gpd-1 PA3001 ARL-1 Cdlc2 TUBB RHOG rac1 SS1G_13726 ArfA11 Dync1i2 rhoq PGTG_12204 LMJF_21_1860 Dync1i1 RHOJ tubb apa-2 RHOQ LMJF_22_1110 DYNC1I2 tbb-1 GL50803_00101291 gpd3 tbb-2 1278252 LOC100184511 tbb-4 rac-2 Map2k7 tbb-6 Dync2h1 Gm3839 Nmdar1 LMJF_04_0480 LOC100073534 gap Arf102F 8039354 Grin1 DYNC1I1 PHYPA_016713 DYNC1H1 RAC6 RAC7 RAC4 RAC5 BRAFLDRAFT_127489 Pacsin1 CNA04650 Rab8a BRAFLDRAFT_127488 GRIN1 Map2k4 kl-3 DAPPUDRAFT_300845 SCO7040 PF14_0124 ben-1 RABA1A PHYPA_016711 ARAC11 AgaP_AGAP003226 Mapk9 NCU08340 betaTub85D SH3GL3 mig-2 cRac1A Gapdh1 EHI_181250 Act88F LOC_Os12g39070 cyc1 Gapdh2 actc1b actc1a ACTG2 DCTN1-p150 ACTG1 tdh1 rac1a rac1b PF3D7_1462800 LOC100021555 CAPN9 BATDEDRAFT_15405 CAPN6 CAPN7 EHI_197840 Os05g0438800 CAPN5 CAPN2 CAPN3 EP300 1271006 CAPN1 Cyt-c1L v1g118944 1271128 HAC1 HAC2 HAC5 SS1G_04652 HAC4 rac1A rac1B arf-6 EHI_070730 rac1C Ap2a2 BATDEDRAFT_37213 Ap2a1 arpc1a gpdA arf-3 GPD1 Act42A dynll2b BRAFLDRAFT_115291 tubb2 Gapdhs tubb6 tubb5 BRAFLDRAFT_60743 DR_1343 v1g210933 1271023 TRIADDRAFT_56111 CYC1 Dynll1 Actg1 PACSIN1 Dynll2 Actg2 LMJF_30_2970 Capn9 Capn8 8026889 Capn5 Capn7 Capn6 Capn1 Capn3 Capn2 TB927.1.2330 BRAFLDRAFT_94959 betaTub60D Dlg4 DLG4 DAPPUDRAFT_306746 EOG090X0E68 GL50803_0017043 LOC100093050 TDH3 DNAL4 Act79B TDH1 LMJF_30_2980 cdc42 TNFAIP8 BRAFLDRAFT_60807 Mtl WBGene00275837 Tb10.6k15.3850 At4g27360 8026892 Ift57 map2k4a Dnal4 acta1b CASP8 ARC40 CASP6 CASP3 apaf1 actr2 DAPPUDRAFT_308639 grin1a grin1b IFT57 dhc1 actr2a DNAI2 Arp53D Tbp TBP gex-2 ACTA2 acta1a arpc5b ACTA1 act10 Arf51F 1281498 HYPOXIA RESPONSE VIA HIF ACTIVATION%PANTHER PATHWAY%P00030 Hypoxia response via HIF activation AKT1 pten DR_A0164 1269396 akt-1 ARNT 8032922 Tor pteN trx PF14_0545 akt2 trx-1 TPTE TXN Txn HIF1A Mtor png-1 Hif1a trxA1 Vhl VHL EGLN1 dhd CREBBP EGLN3 EGLN2 Pten MTOR TRX1 Crebbp trxA CNF03740 1278949 TOR2 TOR1 PTEN2A PTEN RORC tor1 TXN2 akt3b Egln1 Egln2 Egln3 Akt3 AKT2 AKT3 Akt2 Akt1 INFLAMMATION MEDIATED BY CHEMOKINE AND CYTOKINE SIGNALING PATHWAY%PANTHER PATHWAY%P00031 Inflammation mediated by chemokine and cytokine signaling pathway Il10rb CXCR4 PRKX CXCR6 rac-2 GNAI1 RELA GNAI2 RELB PAK1 Pak1 CXCR1 CXCR3 LOC100073534 CXCR2 PAK6 Pak6 PAK3 Pak3 Pak2 PAK2 PAK5 Pak5 PAK4 Pak4 PHYPA_016713 cxcr4a BRAFLDRAFT_127489 cxcr4b CNA04650 pak2 BRAFLDRAFT_127488 pak4 F47F2.1 Il1b 1281793 PF14_0124 PHYPA_016711 cRac1A mig-2 Cxcr1 CCL4L2 Cxcr2 EHI_181250 Act88F Cxcr3 INPPL1 Mapk1 pkaC actc1b actc1a Mapk3 ACTG2 ACTG1 pkaA Rgs4 RGS4 rac1a rac1b mak-2 EHI_197840 Rgs1 Os05g0438800 CCRL2 Cxcr4 Cxcr5 Cxcr6 gnai3 1269396 gnai1 plc1 pka1 zip MYH15 CASK Prkx MYH1B gnaia Rela Relb rac1A rac1B rac1C MYH1G arpc1a RAF1 Raf1 Pka-C1 Act42A arpc2 Cxcl10 BRAFLDRAFT_115291 myhz1.2 MPK10 myhz1.1 CCL3L3 C5AR1 ALOX15 C5ar1 Gnao1 UMAG_04456 MPK13 Cask MPK14 Myh11 Myh14 ALOX12 MPK11 myhz1.3 Myh13 Myh10 Il6 Grk2 BRAFLDRAFT_60743 myhc4 Gnaq v1g210933 GRK6 Grk6 MYH13 1281188 prkacbb TRIADDRAFT_56111 Pik3cg MYH14 MYH11 Pik3cb MYH10 Pik3cd Actg1 Actg2 Pik3ca Alox12e gnaq PLC4 PLC3 ninaC Gprk2 BRAFLDRAFT_94959 PLC2 FUS3 PLC1 GNAO1 CaMKII PLC7 GNAQ DAPPUDRAFT_306746 COL20A1 GNB3 Gnb3 Ltb4r2 Act79B AgaP_AGAP008039 cdc42 CXCL8 Mtl CrMPK2 WBGene00275837 acta1b plc-2 plc-3 plc-4 SS1G_12343 PLCZ1 Pdpk1 Ifng ARC40 LOC114673087 myhb myha plc-1 Nfatc4 Nfatc3 Nfatc2 unc-43 Arp53D PDPK1 PLA2G4B PLA2G4A Prkaca Prkacb Cx3cr1 DAPPUDRAFT_319998 ARC35 C46H11.3 ACTA2 acta1a MYH1 arpc5b ACTA1 Myh1 MYH2 Myh2 MYH3 Myh3 IFNG act10 COL6A2 1281498 COL6A1 MYH8 Myh8 LOC100020439 Lta MYH9 COL6A3 Ras64B Myh9 AgaP_AGAP000018 MYH4 act18 Myh4 MYH6 Myh6 MYH7 Myh7 CAMK2B Gna11 arx-3 RGS17 CAMK2D arx-5 RGS13 Gna15 akt2 MIP-3alpha Gna14 CAMK2A Ifnar1 Rgs17 GNA14 CYTH2 Rgs18 GNA15 GNG3 Gng3 GNG2 Gng2 GNG5 Gng5 Rgs14 GNG4 Gng4 GNG7 rac3a Gng7 act23 GNA11 rac3b act22 BRAFLDRAFT_56698 GNG8 MAPK1 Gng8 PTK2B arx-6 CAMK2G arx-7 WBGene00098673 Ltc4s MAPK3 Fpr-rs4 Actc1 Actbl2 gng2 Fpr-rs3 gng3 Act87E CNA03840 Ptk2b ACTC1 Raf ALOX5AP BRAFLDRAFT_56687 Jra Ccr1l1 KRAS SNOG_03299 Fpr-rs7 Fpr-rs6 Cyth2 arcA UMAG_03305 Tb10.389.0490 COL12A1 ARAF ARPC5L arc3 arc2 arc5 MYLK arc4 akt3b PREX1 AKT2 Akt3 PRKACG Akt2 AKT3 Akt1 C3ar1 PLCE1 AKT1 EHI_129750 PRKACA BRAFLDRAFT_126918 arcC PRKACB JUNB arcB arcE Plc21C arcD Acta1 Acta2 PRKCB PRKCE Plcg1 SS1G_08733 myo3a Araf Plcg2 BRAFLDRAFT_114958 act-2 arc1 act-1 Prkcb DICPUDRAFT_48914 Prkce act-4 act-3 act-5 BRAFLDRAFT_79607 TVAG_090470 Jund BRAFLDRAFT_122664 FPR1 Fpr1 AgaP_AGAP011840 Plch1 FPR3 Fpr2 PRKCZ Myh7b Tak1 BRAFLDRAFT_215305 PLCG2 PLCG1 braf Prkcz ARC19 MYH7B Nfkbie Jun JUN JUND ARC18 grb2a NFATC3 NFATC2 NFATC1 BRAF Pik3c2g ARC15 Nfkbia NFATC4 Mylk ACT Act spk1 Rel Os12g0163700 DICPUDRAFT_46519 Junb Plcb4 Plcb3 Ikbkb Stat6 Col12a1 ARPC1B ARPC1A Ikbke Plcb2 Plcb1 IKBKB Fpr-s1 act Tb09.211.0620 Nfkb2 Nfkb1 itpr1 AgaP_AGAP009115 Adcy2 JAK2 Jak2 PF4V1 Adcy5 Adcy6 RRAS2 BRAFLDRAFT_125401 PLCB3 actin PLCB4 prkacaa LOC100029767 cxcr4 PLCB1 Ptgs1 PLCB2 Act57B PGTG_05488 prkacab Ptgs2 CCL13 CCL11 camk2d1 pikB pikC TRIADDRAFT_49626 ADCY2 Os05g0106600 PTGS2 Plcd1 ADCY6 Plcd4 PTGS1 ADCY5 Ccl11 NRAS Ccl12 UMAG_11232 Ptafr pikA CCL18 Inppl1 Pf4 Prex1 Cx3cl1 CCL22 TPK3 CCL21 TPK2 Grap2 CCL20 TPK1 STAT3 PFL2215w Plce1 pkac-1 CYIIIB cRhoA Ccl22 CYIIIA LOC112204126 Ccl20 BRAFLDRAFT_114976 Stat3 mpk-1 DICPUDRAFT_90232 Stat1 LOC685590 PLCD3 PLCD4 PLCD1 CCL27 v1g188243 PF4 CCL26 AgaP_AGAP009207 MYLK2 SNOG_10086 TVAG_337240 Col14a1 Socs5 MYLK3 Socs7 Socs6 Map3k4 PHYPA_005833 LOC100176797 acnA 37852 v1g169611 BRAFLDRAFT_58093 MAP3K7 MAP3K4 akt-2 akt-1 ced-10 v1g234494 v1g236559 SNOG_01139 Mylk2 Nras pla2g4a LTB4R2 SS1G_11866 CEK1 actg1 IFNAR1 LOC100185123 Shc1 SHC1 ITPR1 ITPR2 ITPR3 Itga9 BRAFLDRAFT_116948 Itga4 Ggamma1 Itga2 SOCS6 SOCS7 SOCS4 SOCS5 Act5C myh10 Arpc1 Arpc3 Arpc2 ARPC4 ARPC5 Ccl21b NFKB2 Ccl21a CXCL10 8029221 ARPC2 ARPC3 BRAFLDRAFT_114535 1281871 Bcl3 Arpc5 Arpc4 Cish Itpr3 Itpr2 mbt Itpr1 ITGB1 Alox12 Myo3a KSS1 COL14A1 CBG02167 acta2 v1g242065 PTEN PIK3CD BRAFLDRAFT_126324 Alox15 PIK3CB ITGAL PIK3CG CBG02162 PF3D7_0934800 CBG02161 ACT1B ACT1A Itgam IscW_ISCW024111 ACT1C ITGB7 Itgal Os07g0694000 ACT12 VWF CHUK mapk3 Itgb7 mapk1 Itgb1 TVAG_054030 ACTBL2 PIK3CA MYO3B Itgb2 MYO3A BRAFLDRAFT_115565 BRAFLDRAFT_115566 SOS1 Sos1 LOC100028958 ITGA9 CX3CR1 DICPUDRAFT_85721 NFAT5 actc2 ROCK1 actc1 act9 act3 Camk2g CDC42 Camk2d Camk2b CCL8 Ccl8 NCU03438 CCL7 Ccl7 actba Plcl2 Plcl1 Camk2a Ccl5 CCL5 Ccl4 CCL4 actbb CCL3 Ccl3 Ccl2 CCL2 Cdc42 Act1 ACT1 Col6a1 Col6a2 PLCL1 plc PLCL2 pik3ca Col6a6 LOC100016601 pak-1 Col6a3 Pten Nfat5 ACT2A act1 1279875 Chuk Rock1 MPK4 MPK5 MPK6 MPK7 mlck-1 myhz2 MPK1 Il36a ACTB MPK2 MPK3 junbb ANIA_07487 Arpc3B ACT9 Act7 ACT7 Act5 ACT4 ACT5 ACT2 ACT3 norpA Alox5ap EHI_107290 pkac1 mpkB Actb Arpc1b Arpc1a GL50803_0040817 actb TRIADDRAFT_63375 Gng10 Pi3K92E IDA5 GNG10 Ifngr2 RRAS gna11b Ifngr1 1281462 sl Grap CCR10 LOC100092493 CCR1 Ccr1 kin-1 Xcr1 XCR1 SNOG_12991 GNG12 TVAG_512800 1281597 fadA GRAP Gng12 Il15 Rhog egl-8 Pla2g4a Rhoc Rhoa CX3CL1 CBG14305 prkcb cdc-42 BRAFLDRAFT_127490 Rac2 Ccr9 RAC2 CCR9 racA Ccr8 CCR8 RAC3 CCR7 Ccr7 RAC1 racB CCR6 Rac1 Ccr6 Ccr5 CCR5 CCR4 Ccr4 CCR3 Ccr3 CCR2 Ccr2 gna-1 Tyk2 RHOG rac1 SS1G_13726 RHOC VAV1 Vav1 RHOA Rras Gnai2 Gnai1 Vwa2 ras-1 Arpc5l Gnai3 CXCR5 GNAI3 INSULIN IGF PATHWAY-MITOGEN ACTIVATED PROTEIN KINASE KINASE MAP KINASE CASCADE%PANTHER PATHWAY%P00032 Insulin IGF pathway-mitogen activated protein kinase kinase MAP kinase cascade Ins1 S6kII UMAG_03305 IRS1 Irs1 Ins2 rskn-1 STY8 MPK4 Irs4 IRS4 Mapk1 MPK5 IRS2 MPK6 Irs3 MPK7 Elk1 MPK1 ELK1 MPK2 Mapk3 MPK3 IGF1R RPS6KA4 RPS6KA3 mak-2 RPS6KA6 RPS6KA5 RPS6KA2 RPS6KA1 At5g58950 igf1 igf1rb igf1ra MAP2K3 gefY MAP2K1 MAP2K2 STY46 mpkB SS1G_11866 CEK1 gefR irs4 Raf1 RAF1 SIS8 Os01g0641000 Mkk4 MPK10 Rasa1 Insr MPK13 MPK14 MPK11 CTR1 Rps6kb1 Rps6kb2 Igf2r 1272910 At3g06640 JIL-1 INSR grb2a grb2b Igf2 IGF2 IGF1 Igf1 Dsor1 RPS6KA IGF2R FUS3 spk1 Sos Grb2 1271952 Igf1r igf2a STY13 KSS1 CrMPK2 STY17 map2k4a igf2b ptgfr BRAFLDRAFT_128184 drk INSRR mapk3 SIRT6 FOS Fos At4g23050 InR mapk1 Rps6ka3 Rps6ka4 chico RASA1 Insrr Rps6ka1 Rps6ka2 fosab SOS1 Sos2 Sos1 SOS2 rsks-1 sem-5 gefA gefB INS DDB_G0271682 MAPK1 EDR1 MAPK3 At3g58640 At4g24480 ins Map2k4 Map2k3 At5g11850 Map2k2 At4g31170 Map2k1 RPS6KB1 RAF11 RPS6KB2 mpk-1 SNOG_03299 AgaP_AGAP009207 INSULIN IGF PATHWAY-PROTEIN KINASE B SIGNALING CASCADE%PANTHER PATHWAY%P00033 Insulin IGF pathway-protein kinase B signaling cascade Mdm2 Mdm4 MDM4 LOC685590 Igf1r gsk3ab gsk31 PTEN2A igf2a PKH2 PKH1 GSK3B Ins1 GSK3A PKH3 gsk-3 IRS1 Irs1 Ins2 Irs4 PTEN INPPL1 IRS4 IRS2 Irs3 mdm2 igf2b IGF1R Pdpk1 BRAFLDRAFT_128184 igf1 pten gsk3ba Foxo3 gsk3bb Pk34A igf1rb igf1ra Foxo1 Pdk1 ksg1 PDPK1 INSRR Tsc2 TSC2 TSC1 PTEN1 Tsc1 Tpte InR OSJNBb0008G24.23 foxo Gsk3b CBG07560 Gsk3a chico PIK3CA Insrr pteN irs4 daf-18 Insr TPTE FOXO3 C44H4.6 FOXO1 INS prk-1 Igf2r Inppl1 Pik3ca gskt INSR pik3ca Igf2 IGF2 IGF1 Pten Igf1 foxo3b IGF2R ins MDM2 INTEGRIN SIGNALLING PATHWAY%PANTHER PATHWAY%P00034 Integrin signalling pathway src-1 rap2ab rap2aa COL12A1 ARAF ARPC5L vps-34 Itgbl1 actn1 scb EHI_129750 Col10a1 VPS34 BRAFLDRAFT_126918 actn4 arcE rap2a rap2b rap2c Col9a2 Araf Col9a3 Col9a1 act-5 rap1aa COL13A1 mys rap1b Fn1 rnd3a paxB arf1 vkg ARFA1A grb2a grb2b FN1 Pik3c2b BRAFLDRAFT_263946 Col8a1 BRAF Pik3c2a Col8a2 Pik3c2g ARFA1F COL1A1 COL1A2 rapA Rap1 ItgaPS5 ItgaPS4 ARF1 ARF2 Arf1 Col12a1 ARPC1B Pax ARPC1A RAS2 Braf RAS1 Shc rasG COL10A1 arfA rasA SIRT6 rasB rhoab rhoaa COL2A1 RAPGEF1 LOC100029767 Pik3r1 Pik3r2 Pik3r3 PGTG_05488 Arf6 ARF6 Col11a1 pikB Col11a2 nras pikC COL11A1 COL11A2 hrasb ced-5 hrasa Dnajc27 1274451 NRAS MICALL1 FLNA FLNB pikA Lims1 Lims2 COL3A1 atn-1 cRhoA cRhoB AgaP_AGAP009200 LOC685590 LIMS2 Frk LIMS1 COL16A1 ITGA2B Col14a1 Map3k5 Map3k4 map3k14b Src64B 37852 v1g169611 Arfgap1 arl1 if MAP3K4 MAP3K5 col2a1 MAP2K3 MAP2K4 MAP2K1 MAP2K2 COL27A1 Col5a2 Col5a3 Col5a1 fn1a v1g234494 Src42A Map3k3 Map3k2 1279656 Map3k1 Nras DAPPUDRAFT_301996 CEK1 Flna actg1 Flnb COL17A1 Shc1 SHC1 Col13a1 ARL1 Itga7 Itga8 Arl1 Itga5 Itga6 Itga9 RAP1B RAP1A Itga3 Itga4 Itga1 Itga2 Abl1 col1a2 Arpc1 Col4a3 Col4a4 Col4a1 Arpc3 rhea Col4a2 Arpc2 v1g247341 Col4a5 ARPC5 Col4a6 8029221 EHI_058090 ARPC2 ARPC3 Sos ITGA10 ITGA11 Arpc5 ITGB1 jnk-1 ITGAM ITGB5 COL14A1 ITGB4 ITGB3 v1g242065 ITGB2 PIK3CD Itgax PIK3CB ITGAE Itgav PIK3C2A ITGAL arf6b PIK3CG PIK3C2B Itgam ITGAX ITGB8 ITGAV Itgae ITGB7 ITGB6 Arhgap10 Itgal abpA ITGA4 mapk8 Itgad ITGA3 ITGA2 ITGA1 mapk3 Itgb6 Itgb7 ARFGAP1 mapk1 Itgb1 ACTBL2 ITGAD PIK3CA Itgb4 Itgb5 Itgb2 Itgb3 ITGA8 ITGA7 PIK3C3 ITGA6 ITGA5 SOS1 let-60 Sos2 SOS2 Sos1 CRK Crk LOC100028958 ITGA9 Arhgap26 COL15A1 Src SRC NTN4 Ntn4 LanA Bcar1 CDC42 actba actbb FYN Fyn CSK Csk crk Cdc42 Mapk13 piki-1 Col6a1 Col6a2 pik3ca Col6a6 LOC100016601 Col6a3 PTPN12 Itgbn fyna C3G fynb v1g166872 csk BCAR1 Mapk10 Col18a1 AgaP_AGAP001381 arf2a ACTB CRKL Crkl Arpc3B AgaP_AGAP006826 Col1a2 Col1a1 ACTN3 emb-9 ACTN2 ACTN1 rho-1 ACTN4 Actb Arpc1b Arpc1a COL8A2 COL8A1 bsk TLN1 Tln1 actb ptk2ab Vasp Col17a1 PIK3R3 PIK3R2 Pi3K92E PIK3R1 RRAS Grap RHO4 rhoA Rho1 RHO1 LOC100092493 VASP AgaP_AGAP011036 rho5 PARVA PARVB rho1 Ptk2 PTK2 INTB Parvb COL9A1 Parva ITGBL1 COL9A3 Grb2 COL9A2 GRAP parvaa Rap2b EHI_049030 Rap2a epi-1 Rap2c TRIADDRAFT_63238 Rap2l Rhoc Pik3c3 Rhoa Rhob CELE_K02B12.7 RAC2 racC Rac1 racB RAC1 HRAS Rap1a Col3a1 Rap1b rac1 RHOC RHOA RHOB RAP2C RAP2A RAP2B Actn2 Rras Actn3 Actn1 Actn4 Vwa2 AgaP_AGAP007849 rhob ras-1 stck wb DAPPUDRAFT_301818 8039354 MAP3K2 Col2a1 MAP3K3 MAP3K1 CNA04650 kin-32 Megf9 Map2k4 Map2k3 Map2k2 Map2k1 Hras Mapk9 cRac1A Mapk8 EHI_181250 Mapk1 Mapk6 Mapk3 ACTG2 ACTG1 rac1a rac1b DMBT1 EHI_197840 Ras85D let-2 lam-3 lam-2 LANB2 Lama5 rac1A rac1B COL4A2 arpc1a LanB1 Lama1 COL4A1 Lama2 LanB2 COL4A4 Lama4 COL4A3 COL4A6 ELMO1 COL4A5 ELMO2 RAF1 Raf1 VCL Vcl arpc2 Mkk4 Itgb2l PXN Pxn DNAJC27 Elmo2 v1g210933 Elmo1 Pik3cg Pik3cb Pik3cd Actg1 Itga10 Itga11 Pik3ca age-1 mapk10 CAV1 Cav1 ARHGAP26 COL5A1 COL5A3 COL5A2 DAPPUDRAFT_306746 COL20A1 EOG090X0E68 ina-1 LOC100093050 cdc42 LAMC3 Ilk ILK LAMC2 LAMC1 RND2 Rnd2 RND3 Rnd3 map2k4a RND1 Rnd1 1281247 Asap1 vps34 ilk ACTA2 ARHGAP10 arpc5b Itga2b ACTA1 COL6A2 COL6A1 LOC100020439 COL6A3 AgaP_AGAP000018 DOCK1 Pi3K68D LAMA5 TRIADDRAFT_20369 LAMA2 LAMA1 LAMA4 LAMA3 ASAP1 Dock1 MAPK9 pat-3 MAPK8 Lamb2 Lamb3 rac3a rac3b act22 PTK2B Ptpn12 v1g243859 Lamb1 MAPK6 arx-7 MAPK3 Vinc SS1G_03867 Actbl2 Pi3K21B LAMB3 LAMB2 LAMB4 LAMB1 Ptk2b kras MAPK13 MAPK10 ACTC1 Lamc3 AgaP_AGAP010273 BRAFLDRAFT_56687 Lamc1 KRAS Lamc2 INTERFERON-GAMMA SIGNALING PATHWAY%PANTHER PATHWAY%P00035 Interferon-gamma signaling pathway Socs3 Socs2 Mapk8 UMAG_03305 csw MPK4 Mapk1 MPK5 MPK6 MPK7 Socs5 MPK1 Socs4 MPK2 Mapk3 Socs7 MPK3 Socs6 Pias3 Pias4 mak-2 MPK8 MPK9 Pias1 p38b Pias2 p38a LMPK PIAS4 PIAS3 Tb10.6k15.2790 CISH MPK20 mpkB PIAS2 PIAS1 Su(var)2-10 SS1G_11866 CEK1 PF3D7_1113900 bsk MPK10 mapk14a MPK13 MPK14 MPK11 MPK18 MPK15 MPK16 SOCS2 SOCS3 MPK19 Ifngr2 Ifngr1 mapk14b SOCS6 SOCS7 SOCS4 SOCS5 Socs36E mapk10 stat1a SS1G_05445 gei-17 pmk-2 FUS3 pmk-1 spk1 Cish mapk12 jak2a jnk-1 KSS1 CrMPK2 erkB Ifng JAK2 Jak2 Jak1 JAK1 mapk8 IFNGR1 IFNGR2 mapk3 jak1 mapk1 IFNG Ptpn6 mapk-15 MAPK9 MAPK8 Ptpn11 MAPK1 MAPK3 Mapk12 Mapk13 Mapk14 Mapk15 STAT1 PTPN11 MAPK14 MAPK15 MAPK12 MAPK13 MAPK10 ptp-2 MAPK11 ptpn11a mpk-1 Stat1 PTPN6 SNOG_03299 Mapk10 Mapk11 AgaP_AGAP009207 Mapk9 INTERLEUKIN SIGNALING PATHWAY%PANTHER PATHWAY%P00036 Interleukin signaling pathway Elk4 RPS6KA6 AKT2 MYC Myc RPS6KA2 Akt3 AKT3 RPS6KA1 Akt2 Akt1 AKT1 gsk3ba gp130 IL13RA2 IL6R MAP3K7 gsk3bb MAP3K4 IL13RA1 IL15RA IL4R IL11RA Araf Il20ra Il23a Nras IL23A CEK1 MAPKAPK2 Il5ra RAF1 IL6ST Raf1 Shc1 SHC1 Rasa1 IL20RA FOXO3 Il4 Csf2rb2 Il6 Tak1 LOC100012174 Il9 Pik3cb Il6r STAT5A Il12rb1 STAT5B Pik3ca Il12rb2 Il4r grb2a stat1a BRAF RPS6KA IL4 Spic IL6 Stat5a Stat5b IL9 LOC100011470 IL21 GSK3B Il11 LOC100360218 Ikbkb CDKN1A GSK3A CXCL8 CDKN1B mknk1 Stat6 Il15 Stat4 Il2ra Il2rb Il16 Braf PIK3CB Il15ra IKBKB Pdpk1 Csf2rb Jak3 JAK3 Foxo3 Il13ra1 IL11 Il13ra2 CHUK IL15 PDPK1 mapk3 FOS Fos mapk1 Gsk3b Rps6ka3 IL1A PIK3CA RASA1 Rps6ka1 Rps6ka2 IL3RA SOS1 Sos2 Sos1 SOS2 Il6st SRF Srf Il10rb Il10ra Mtor NRAS MAPK7 CXCR1 stat3 MKNK1 MKNK2 CXCR2 STAT4 MAPK1 STAT6 MAPK6 Il11ra2 IL12RB1 IL12RB2 MAPK3 Mapkapk2 Mapk15 Il11ra1 Nos3 NOS3 STAT1 IL10RB STAT2 IL10RA STAT3 pik3ca MAPK15 stat5a MTOR Il1a Il6ra IL2RA IL2RB Mknk2 Stat3 Mknk1 Stat2 LOC685590 Stat1 Chuk Cdkn1a Cdkn1b Mapk7 Spi1 S6kII SPI1 IRS1 Irs1 ARAF Mapk1 IL5RA IRS2 Elk1 SLA2 Mapk6 ELK1 Mapk3 Elk3 Map3k4 ELK3 akt3b ELK4 SPIC RPS6KA3 IONOTROPIC GLUTAMATE RECEPTOR PATHWAY%PANTHER PATHWAY%P00037 Ionotropic glutamate receptor pathway KaiR1D AgaP_AGAP009443 aex-4 gria4a gria4b Cacng5 Cacng2 nsfA NSF Nsf Dmel\CG31495 gria3b slc1a1 gria3a Gria4 Gria3 Gria2 Gria1 1281696 nmr-1 comt GRIA1 Grin2a nsf GRIA2 SLC1A1 SLC1A2 glr-6 SLC1A3 glr-4 slc1a3a glr-2 SLC1A6 SLC1A7 glr-1 GRIN2A Slc1a1 Slc1a3 Slc1a2 Slc1a7 Slc1a6 nSyb GRIA3 SNAP-25 GRIA4 Grin3b AgaP_AGAP006027 Grin3a grik1b GRIN2C GRIN2B Snap29 GRIN2D GLR3.7 Snap24 GRIN3A Snap25 CaMKII 1270340 SCO4498 Grik5 GLR3.2 Grik2 Grik1 Grik4 Grik3 Grin2d ANIA_08769 stx11a Grin2c Grin2b Shank2 SNAP25 Shank1 Shank3 GRIK5 snap-29 SNAP23 GRIK3 Pick1 GRIK4 GRIK1 GluRIA GRIK2 GluRIB GRM3 Grm3 Grm2 GRM2 1272250 AgaP_AGAP000801 shn-1 grin1a grin1b Syb SNAP29 unc-43 Vamp8 SNAP33 slc1a2b SEC18 Vamp1 SNAP30 Vamp3 Vamp2 VAMP8 Stx19 PICK1 VAMP1 sec18 SHANK3 VAMP2 cacng5b SHANK2 VAMP3 Stx11 SHANK1 CAMK2B CAMK2D snb-1 camk2d1 syb1 ric-4 vamp8 STX19 CAMK2A glt-4 gria2a gria2b glt-5 Prosap glt-1 STX11 Camk2g SNC1 Camk2d si:dkey-183j2.10 Camk2b Nmdar1 PF3D7_0303000 1272393 Camk2a snap25a KBP SLC17A6 snap25b Eaat2 Slc17a1 SLC17A8 Eaat1 Grin1 CACNG2 Slc17a8 CAMK2G CACNG5 Slc17a6 nsf-1 NCU03387 TB927.1.1560 GRIN1 ISOLEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02748 Isoleucine biosynthesis PAE3300 PA4180 ilvD1 ilvD2 ILV5 ILV3 NCU04292 Ilvbl SCO5512 SCO2769 ILVBL MA_3792 Os05g0558400 NCU04579 1272265 ALS1 DHAD ilvC2 ilvC1 DR_1516 BCAT1 BCAT3 PA2035 BCAT2 ilvD ilvC BCAT4 BAT1 BCAT7 ilvE BAT2 BCAT6 ilvG ilvI ilvK ilv5 ilvB1 DR_1626 ILV2 ilvB ilv-2 Dmel\CG1673 SPAC17G8.06c NCU05683 MA_1958 BT_2074 CBG03380 MJ0663 ilv1 MA_1354 CELE_Y44A6D.5 ilvE2 yagF ilvB-3 ilvB-2 ilvB-5 bcat-1 ilvB-4 At3g58610 ilvB-1 alsS yjhG T26C12.1 ALS SCO1888 Bcat1 ilvB-6 TM_0548 Bcat2 SCO1176 JAK STAT SIGNALING PATHWAY%PANTHER PATHWAY%P00038 JAK STAT signaling pathway Jak1 JAK1 Pias2 STAT5A Ptprc PIAS3 STAT5B Mapk14 STAT1 STAT3 stat1a MAPK14 jak1 stat5a PIAS2 PIAS1 Stat5a PTPRC Stat5b Stat3 LOC100011470 Stat2 Stat1 Socs1 jak2a Stat6 Stat4 mapk14a Pias3 Pias4 SOCS1 stat3 LOC100012174 STAT4 mapk14b STAT6 JAK2 Jak3 Jak2 JAK3 Pias1 LEUCINE BIOSYNTHESIS%PANTHER PATHWAY%P02749 Leucine biosynthesis leuD LEU4 DR_1626 LEU9 IMDH1 leu-1 leu-4 NCU04292 IMDH3 leu2 Dmel\CG1673 leu3 leu1 cimA aksA Os05g0558400 1272265 PAE1995 CELE_Y44A6D.5 MAM3 ilvE2 MA_4264 MAM1 BCAT1 BCAT3 BCAT2 BCAT4 BAT1 BCAT7 ilvE bcat-1 BAT2 BCAT6 SNOG_02041 hacA ilvK leuC2 leuC1 Bcat1 leuA1 Bcat2 BT_1858 leuB YALI0_B01364g LEU2 leuC LEU1 leuA LIPOATE_BIOSYNTHESIS%PANTHER PATHWAY%P02750 Lipoate_biosynthesis LIP1 Las lipA1 LIP2P LIP5 LmjF19.0350 LIP1P M01F1.3 3289702 lipA2 SPAC4F10.05c Lias LIAS AgaP_AGAP010568 8025271 CG9804 lip5 Lipt2 lipA LIP2 LIP1P-1 lipB LYSINE BIOSYNTHESIS%PANTHER PATHWAY%P02751 Lysine biosynthesis dapA-3 dapA-2 NCU03935 dapA-1 PA4188 dapA dapB SPBC19F5.04 TM_1523 At5g21060 DAPF astC At1g14820 SCO3615 LYSA1 LYSA2 lysJ arg1 SCO6292 DAPB3 dapG dapF DAPB1 DAPB2 8025209 AK1 AK2 lysA BT_1375 dapA2 dapA1 lysC dapAL At1g01630 yclM AKHSDH1 Os09g0294000 ARG8 gll1774 WIN1 PA1254 HOM3 BT_3320 NCU04118 HOM6 BT_1901 aruC asd DDB0169465 glr1017 ask yagE P0482D04.19 argD SPBC776.03 usg yjhH SCO1889 arg-8 TM_0547 SCO0315 TM_1518 DR_1365 MA_0131 BT_2403 PA0223 MANNOSE METABOLISM%PANTHER PATHWAY%P02752 Mannose metabolism Gmppa algD Gmppb MPI MPG1 SCO1388 CYT1 GMPPB DR_0710 C05C8.7 MAN1 GMDS manA SCO0382 cugP GMPPA Os01g0127900 CBG12186 At4g30570 PMI1 bre-1 MUR1 F9E10.24 PMI40 PMI2 PMM1 Pmm2 mpg At2g04650 Pmm1 PMM2 At3g55590 wbpA PMI PMM sll1496 Gmds PAE3554 CELE_Y47D9A.1 PSA1 noeL gmd-2 GDPMP gmd METABOTROPIC GLUTAMATE RECEPTOR GROUP III PATHWAY%PANTHER PATHWAY%P00039 Metabotropic glutamate receptor group III pathway gnai2a gnai2b prkar1ab PRKACG prkar1aa PRKACA PRKACB gpb-2 gpb-1 pkac1 Vti1a slc1a1 STX1B Gbeta13F gnb1b LMJF_35_3960 PRKAR1B PRKAR1A 1281696 STX1A Grin2a stx1b Gng10 slc1a3a stx1a GRIN2A GNG10 Galphai PRKAR2B PRKAR2A BRAFLDRAFT_220697 VTI1A Grin3b kin-2 Stx1b kin-1 Grin3a Gngt2 grik1b GRIN2C GRIN2B Stx1a LA_1929 Snap29 GRIN2D Snap24 GRIN3A Snap25 1270340 Grik5 Snap23 Grik2 Grik1 Grik4 Grik3 Grin2d Grin2c AgaP_AGAP002578 Grin2b GRIK5 GRIK3 GRIK4 GRIK1 GRIK2 git5 GNGT2 STE4 LA_4008 Syb Vamp8 Vamp1 unc-2 Vamp3 Vamp2 SS1G_03482 VAMP8 GB1 Gnai2 prkacaa VAMP1 Gnai1 VAMP2 VAMP3 prkacab Gnai3 syb1 Prkar1a Prkar1b GNAI3 gria2a gria2b CiGi1 PRKX LmPKAC2b GNAI1 GNAI2 1281667 Nmdar1 Nmdar2 1281784 snap25a snap25b SLC17A7 Grin1 Slc17a7 gnb-1 Cacnb1 Gbeta5 Prkar2a Prkar2b BCY1 GRIN1 LOC112204126 1281793 gpbA AgaP_AGAP009443 aex-4 Cacna1e Cacna1a gnb1 Cacna1b gnb2 pkaC gria4a gria4b DICPUDRAFT_93216 gria3b Prkx gria3a Gria4 gnaia Gria3 CACNB1 Pka-R1 Gria2 Pka-R2 Gria1 nmr-1 prkar1b GRIA1 pdeE Pka-C1 GRIA2 Adcy10 Pka-C3 SLC1A1 pdeD SLC1A2 CACNA1B SLC1A3 CACNA1A gsto1 glr-2 SLC1A6 SLC1A7 CACNA1E glr-1 Gbeta76C 8035476 Slc1a1 Slc1a3 prkacbb prkacba Slc1a2 Slc1a7 Slc1a6 nSyb GRIA3 GRIA4 ADCY10 GLR3.7 GNB2 Gnb2 GNB1 Gnb1 GLR3.2 pkaR GNB4 Gnb4 GNB3 Gnb3 GNB5 Gnb5 ANIA_08769 AgaP_AGAP008039 SNAP25 gngt2a snap-29 SNAP23 GluRIA GluRIB mcb GRM1 Grm1 1276578 GRM5 Grm5 GRM4 1276579 Grm4 1276572 Grm7 GRM7 Grm6 GRM6 GRM8 Grm8 grin1a grin1b SNAP29 SNAP33 sgcA slc1a2b 1276580 Prkaca Prkacb SNAP30 cgs1 DAPPUDRAFT_319998 gnb5b snb-1 ric-4 cac glt-4 glt-5 glt-1 SNC1 si:dkey-183j2.10 GNG3 Gng3 GNG2 GNG5 Gng5 GNG4 prkar2ab Gng4 GNG7 Gng7 KBP Gng8 GNG8 Eaat2 Eaat1 AgaP_AGAP004940 gng2 gng3 gng5 gng7 gnb3b gnb3a 1271234 METABOTROPIC GLUTAMATE RECEPTOR GROUP II PATHWAY%PANTHER PATHWAY%P00040 Metabotropic glutamate receptor group II pathway Prkar1a Prkar1b GNAI3 CiGi1 PRKX LmPKAC2b GNAI1 GNAI2 SNC1 GNG3 Gng3 1281667 GNG2 GNG5 Gng5 prkar2ab Gng4 GNG4 GNG7 Gng7 snap25a GNG8 snap25b Gng8 AgaP_AGAP004940 gpa-4 gpa-3 gnb-1 gng2 Cacnb1 gpa-2 Gbeta5 gng3 Gnat2 Prkar2a gng5 Prkar2b BCY1 gng7 odr-3 LOC112204126 gnb3b gnb3a 1281793 gpbA 1275316 aex-4 gnai2a gng12a gnai2b Cacna1e gnb1 Cacna1a Cacna1b gnb2 pkaC GNAT2 prkar1ab PRKACG DICPUDRAFT_93216 gnai3 prkar1aa PRKACA gnai1 PRKACB gpb-2 gpb-1 pkac1 Prkx gnaia CACNB1 STX1B Gbeta13F Pka-R1 gnb1b LMJF_35_3960 Pka-R2 PRKAR1B PRKAR1A BRAFLDRAFT_60318 STX1A prkar1b pdeE Pka-C1 gngt1 Adcy10 stx1b Pka-C3 Gng10 Gnao1 pdeD CACNA1B CACNA1A gsto1 stx1a CACNA1E Gbeta76C GNG10 8035476 Gnao Galphai PRKAR2B PRKAR2A Ggamma1 BRAFLDRAFT_220697 prkacbb prkacba nSyb Galphao SNAP-25 Stx1b kin-2 kin-1 gpc-1 Gngt2 GNG11 Stx1a LA_1929 Snap29 GNAO1 ADCY10 Snap24 Snap25 GNB2 Gnb2 GNB1 Gnb1 pkaR GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 Gng11 ANIA_08769 AgaP_AGAP008039 AgaP_AGAP002578 SNAP25 gngt2a snap-29 SNAP23 mcb GRM3 Grm3 Grm2 GRM2 1276578 1276579 git5 GNGT2 1276572 STE4 gnao1b Syb SNAP29 Vamp8 SNAP33 Syx1A 1276580 Vamp1 Prkaca Prkacb unc-2 SNAP30 Vamp3 cgs1 Vamp2 DAPPUDRAFT_319998 SS1G_03482 VAMP8 gnb5b GB1 Gnai2 prkacaa VAMP1 Gnai1 VAMP2 Gnai3 VAMP3 prkacab snb-1 syb1 cac ric-4 vamp8 gnat2 METABOTROPIC GLUTAMATE RECEPTOR GROUP I PATHWAY%PANTHER PATHWAY%P00041 Metabotropic glutamate receptor group I pathway 1281793 Grik1 Grin2d AgaP_AGAP008039 Grin2c Grin2b GRINA Itpr1 Plcb4 gna15.1 GRIK5 pkaC GRIK1 GRM1 Grm1 GRM5 Homer1 Grm5 prkar1ab PRKACG prkcb itpr1 grin1a grin1b prkar1aa PRKACA PRKACB PRKCB pkac1 Prkx Prkaca Prkacb DAPPUDRAFT_319998 Pka-R1 LMJF_35_3960 PLCB4 PRKAR1B Prkcb PRKAR1A egl-30 1281696 nmr-1 prkacaa prkacab prkar1b Grin2a Pka-C1 Gna11 Pka-C3 Gna15 Prkar1a Prkar1b ITPR1 RyR PRKX LmPKAC2b GRIN2A GNA15 Nmdar1 GNA11 Gnaq gna11b prkacbb prkacba homer1 Grin1 Grin3b kin-2 kin-1 Grin3a HOMER1 gnaq GRIN2C Grina GRIN2B GRIN1 GRIN2D GRIN3A LOC112204126 itr-1 Grik5 GNAQ pkaR METHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02753 Methionine biosynthesis metB YHR112C SPBC15D4.09c MHT1 yitJ metH IRC7 LOC_Os10g25950 metAS FN1746 SPAC23A1.14c mmuM SCO1657 Os03g0376100 ybgG SCO6137 PAE2420 FN1745 CGS2 DR_0966 CGS1 metr-1 Os01g0772900 AgaP_AGAP008537 Dmel\CG10621 HMT3 HMT-1 MTR cysA Mtr LOC_Os10g26010 TM_0268 HMT-2 Dmel\CG10623 SCO1294 FN0163 aar metAA METHYLCITRATE CYCLE%PANTHER PATHWAY%P02754 Methylcitrate cycle prpB prpD prpE IREB2 aco1 NCU00680 mmgE acn SCO5999 aco-1 MA_0250 Ireb2 acnA PDH1 ACO3 ACO1 citB Aco1 ACO2 1269890 Irp-1B NCU00977 Irp-1A METHYLMALONYL PATHWAY%PANTHER PATHWAY%P02755 Methylmalonyl pathway mutA mcmA2 DR_2032 mcmA1 yqjD DR_1084 ppcB SCO6832 mmdA MCEE TK1149 TK1622 Pcca DR_1189 Pccb MMUT SCO6284 mce-1 SCO4926 DDB0166993 yngE SCO5535 SCO4869 SCO5415 8032893 Mcee TM_0716 PCCA SCO6472 accD4 pcca-1 accD6 pccb-1 PCCB accD5 Mmut DR_1316 mmcm-1 mutB mcee MRNA SPLICING%PANTHER PATHWAY%P00058 mRNA splicing SNRPA U2B'' PRP3 ZRSR2 Snrnp40 PRP4 U1A Prpf3 At2g05720 ZRSR2P1 prp19 prp-4 snf Snrpb2 Snrpa prp3 NWD1 SNRNP40 Zrsr1 PRPF3 SNRPB2 NCU01637 MUSCARINIC ACETYLCHOLINE RECEPTOR 1 AND 3 SIGNALING PATHWAY%PANTHER PATHWAY%P00042 Muscarinic acetylcholine receptor 1 and 3 signaling pathway stx1b Gng10 1269535 stx1a PRKCZ BRAFLDRAFT_132597 GRIN2A GNG10 gna11b BRAFLDRAFT_220697 Galphaq Prkcz SNAP-25 Grin3b Slc5a7 Stx1b gpc-1 Grin3a Gngt2 Ace cho-1 GRIN2C GRIN2B GNG11 pck1 pck2 ChT Stx1a Snap29 GRIN2D Snap24 GRIN3A Snap25 Snap23 AgaP_AGAP012252 Gng11 Grin2d Grin2c Grin2b Plcb4 ACHE prkcq egl-8 prkci git5 GNGT2 STE4 prkcb itpr1 Syb SLC18A3 Ache Vamp8 Syx1A Vamp1 Vamp3 Vamp2 SS1G_03482 Itpr VAMP8 1273594 ache PLCB4 1273596 GB1 VAMP1 VAMP2 VAMP3 syb1 prkchb AgaP_AGAP002370 PKN3 Pkn3 vamp8 vamp2 NCU06544 Pkc98E 1281667 Nmdar1 Nmdar2 snap25a snap25b Grin1 BCHE gnb-1 Gbeta5 ace-1 cha-1 ace-3 ace-2 GRIN1 ace-4 gpbA Pkn2 PKN2 1275316 Pkn1 PKN1 aex-4 Bche CHRM3 CHRM1 gnb1 gnb2 B0395.3 prkcbb prkcba AgaP_AGAP002748 DICPUDRAFT_93216 pkc-1 pkc-2 pkc-3 egl-30 nmr-1 VAChT prkcda gngt1 CHAT ITPR1 ITPR2 ITPR3 cht1 Chrm1 Gbeta76C Chrm3 8035476 Gnaq Ggamma1 1281188 Chat ChAT nSyb tpa-1 gnaq itr-1 GNB2 Gnb2 GNAQ GNB1 Gnb1 GNB4 Gnb4 GNB3 Gnb3 GNB5 Gnb5 ANIA_08769 Itpr3 Itpr2 Itpr1 SNAP25 Gnaq1 gngt2a AgaP_AGAP006475 snap-29 SNAP23 aPKC 1276578 1276579 grin1a grin1b SNAP29 SNAP33 1276580 SNAP30 PKC1 Pkn gnb5b Gna11 snb-1 ric-4 Gna14 SNC2 SNC1 GNA14 GNG3 Gng3 GNG2 GNG5 BRAFLDRAFT_116869 Gng5 GNG4 Gng4 GNG7 GNA11 inaC Gng7 Gng8 GNG8 gng2 gng3 gng5 gng7 gnb3b gnb3a gng12a achE2 Slc18a3 norpA PRKCG gpb-2 PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD Pkcdelta PRKCA Pkc53E Prkcq STX1B SLC5A7 Prkcg Prkch Gbeta13F gnb1b Prkci Prkcb Prkcd 1281696 Prkce PRKCQ Prkca STX1A Grin2a MUSCARINIC ACETYLCHOLINE RECEPTOR 2 AND 4 SIGNALING PATHWAY%PANTHER PATHWAY%P00043 Muscarinic acetylcholine receptor 2 and 4 signaling pathway achE2 PRKACG Slc18a3 GNAT1 prkar1aa PRKACA SYP41 PRKACB syx-16 gpb-2 gpb-1 pkac1 cpt-4 psy1 STX1B SLC5A7 Gbeta13F gnb1b LMJF_35_3960 PRKAR1B PRKAR1A BRAFLDRAFT_60318 SPCC18.02 STX1A GL50803_007309 Gng10 stx1b GL50803_003869 AgaP_AGAP011840 stx1a BRAFLDRAFT_132597 GNG10 Galphai PRKAR2B PRKAR2A BRAFLDRAFT_220697 Galphao SNAP-25 Slc5a7 kin-2 Stx1b kin-1 gpc-1 Gngt2 cho-1 GNG11 ChT LA_1929 Snap29 Stx1a Snap24 Snap25 SLC6A8 Snap23 Gng11 ACHE GL50803_0011214 CBG14305 git5 GNGT2 STE4 LA_4008 Syb Syx16 SLC18A3 Ache Slc6a8 Vamp8 Syx1A Vamp1 Vamp3 Vamp2 SS1G_03482 VAMP8 1273594 ache prt Stx16 1273596 Stx19 GB1 Gnai2 prkacaa VAMP1 Gnai1 VAMP2 Stx11 VAMP3 prkacab Gnai3 syb1 STX16 vamp8 STX19 Prkar1a Prkar1b GNAI3 CiGi1 PRKX LmPKAC2b STX11 GNAI1 GNAI2 1281667 snap25a snap25b Stx4 STX4 Stx3 STX3 STX2 Stx2 snf-6 syn-2 BCHE syn-1 gnb-1 Gbeta5 ace-1 TPK3 cha-1 GL50803_0096994 TPK2 Prkar2a TPK1 Prkar2b BCY1 ace-3 ace-2 ace-4 F47F2.1 pkac-1 LOC112204126 1281793 gpbA 1275316 aex-4 CHRM2 Bche CHRM4 gnb1 gnb2 PF3D7_0210700 pkaC B0395.3 pkaA LOC103690878 DICPUDRAFT_93216 gnai3 gnai1 pka1 Prkx gnaia 4576836 Kcnj3 Pka-R1 Pka-R2 VAChT prkar1b pdeE Pka-C1 gngt1 Adcy10 Pka-C3 Gnao1 CHAT pdeD UMAG_04456 gsto1 cht1 Gbeta76C Chrm2 Gnao 8035476 Chrm4 Ggamma1 Chat prkacbb prkacba nSyb unc-64 CELE_W03F9.4 GNAO1 ADCY10 syx-4 syx-3 GNB2 Gnb2 GNB1 Gnb1 pkaR GNB4 Gnb4 GNB3 Gnb3 syx-2 GNB5 Gnb5 ANIA_08769 AgaP_AGAP008039 SNAP25 gngt2a snap-29 SNAP23 mcb stx3b 1276578 1276579 1276572 SNAP29 SNAP33 sgcA 1276580 Prkaca Prkacb SNAP30 cgs1 DAPPUDRAFT_319998 gnb5b snb-1 ric-4 SYP131 Kcnj9 SYP132 Kcnj6 Kcnj5 SNC1 GNG3 Gng3 GNG2 GNG5 BRAFLDRAFT_116869 Gng5 GNG4 prkar2ab Gng4 GNG7 Gng7 Gng8 GNG8 AgaP_AGAP004940 KCNJ3 KCNJ5 KCNJ6 gng2 gng3 Gnat2 SYP124 KCNJ9 gng5 SYP123 Syx4 gng7 CNA03840 SYP122 SYP121 Gnat1 gnb3b gnb3a gnai2a gng12a gnai2b Tb10.389.0490 SSO1 SSO2 SYP42 GNAT2 prkar1ab MYO_SIGNALING_PATHWAY%PANTHER PATHWAY%P06215 MYO_signaling_pathway Smurf Med alph Fur1 Mad babo myo wit Smox Sara N-ACETYLGLUCOSAMINE METABOLISM%PANTHER PATHWAY%P02756 N-acetylglucosamine metabolism glmS glmU nagB FN1133 nagA nanK yieK T03F6.3 nanA TBC1D24 GL50803_0010829 TVAG_044970 DR_A0066 1269533 Npl NPL GL50803_008245 AMDHD2 Gfpt1 PA3759 Gfpt2 SPBC12C2.11 PA3758 Oscillin FN1474 YMR084W DR_A0154 GFPT2 GFPT1 Gfat1 glmS-1 TM_0814 TM_0813 GNPDA1 GFAT GNPDA2 glmS-2 gfat-1 F59B2.3 gfat-2 1273617 gamA Gnpda1 YMR085W agaI Amdhd2 Gnpda2 GFA1 CG17065 SCO4284 DAC1 glmM Gfat2 LOC101733834 NICOTINE_DEGRADATION%PANTHER PATHWAY%P05914 Nicotine_degradation UGT1A1 Fmo3 FMO3 INMT CYP2A7 CYP2A26 CYP2A6 CYP2A13 UGT1A5 UGT1A4 UGT1A3 UGT2B7 LOC114674219 NICOTINE PHARMACODYNAMICS PATHWAY%PANTHER PATHWAY%P06587 Nicotine pharmacodynamics pathway CLIC6 Cacna1g KCNK9 gnb1 grb2 PPP1CB Chrnb3 Ppp1r1b PPP1CC Chrnb2 Th Slc18a2 gnai3 Adcy2 PRKACA gnai1 SLC18A2 Ppp1ca CHRNB2 CHRNB4 CHRNB3 Prkaca gnb1b Epb41 Flna prkacaa Gnai1 DAPPUDRAFT_194510 DDC Ddc CHRNA3 CHRNA5 CHRNA4 EPB41 CHRNA6 ADCY2 CACNA1C GNAI1 CACNA1G Epb41l2 Kcnk3 Clic6 Epb41l1 GNG2 Gng2 EPB41L1 EPB41L2 FLNA DRD2 Drd2 DRD3 Drd3 DRD4 Drd4 gng2 grb2a BRAFLDRAFT_219190 PPP1CA Chrna3 TH CDK5 Chrna5 GNB1 Gnb1 PPP1R1B ppp1cab TRIADDRAFT_30170 DAPPUDRAFT_231787 KCNK3 NICOTINIC ACETYLCHOLINE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00044 Nicotinic acetylcholine receptor signaling pathway ace-1 Chrne Chrng PFL2215w ace-3 ace-2 ace-4 CYIIIB CYIIIA BRAFLDRAFT_114976 DICPUDRAFT_90232 aex-4 v1g188243 Bche TVAG_337240 PF3D7_0210700 Cbr-myo-2 B0395.3 Chrnb4 VIII-1 Chrnb3 Chrnb2 Chrnb1 PHYPA_005833 LOC100176797 acnA 37852 v1g169611 BRAFLDRAFT_58093 ANIA_06318 VIII-2 1271929 v1g234494 Chrna10 CELE_F41H10.4 SNOG_01139 actg1 VAChT LOC100185123 cht1 BRAFLDRAFT_116948 chrnb5a nAChRbeta1 Act5C myh10 chrna2b nAChRbeta3 nAChRbeta2 Chrna3 Chrna2 Chrna1 syx-4 Chrna7 chrna2a Chrna6 BRAFLDRAFT_114535 syx-3 Chrna5 DAAM Chrna4 Chrna9 syx-2 ANIA_08769 AgaP_AGAP006479 SNAP25 Myo3a CBG02167 acta2 v1g242065 SNAP23 BRAFLDRAFT_126324 CBG02162 CBG02161 ACT1B ACT1A At2g42170 chrnb3a IscW_ISCW024111 ACT1C deg-3 SNAP29 ACT12 SNAP33 SNAP30 TVAG_054030 MYO3B ACTBL2 myo1eb MYO3A BRAFLDRAFT_115565 BRAFLDRAFT_115566 LOC100028958 Myo1c Myo1b Myo1e Myo1d PLEKHH3 actc2 ric-4 actc1 SYP131 act9 SYP132 act3 Myo1g Myo1f Arp1 Plekhh3 arp-1 BRAFLDRAFT_116869 actba actbb spo15 Act1 lgc-10 lgc-11 ACT1 MYO10 SYP124 SYP123 LOC100016601 SYP122 SYP121 MYO19 MYO16 MYO1D MYO1E MYO1B ACT2A act1 MYO1C MYO1A Myo10 Myo15a Myo16 MYO1F MYO1G Slc44a3 Mhc myhz2 ACTB SYP42 achE2 Myo7a ACT9 Act7 jar Myo7b ACT7 SYP41 Act5 ACT4 ACT5 ACT2 ACT3 EHI_107290 MYO7B MYO7A Actb STX1B lfi-1 GL50803_0040817 1272986 actb STX1A 1272988 CTAGE15 TRIADDRAFT_63375 GL50803_003869 Myo5c Myo5b IDA5 1272992 Myo18a Myo5a LOC100092493 Slc5a7 Stx1b MYO5A myh7l cho-1 TVAG_512800 Stx1a 1281358 1270461 Myo28B1 MYO5B MYO5C asp LOC100081497 SLC44A3 chrnd ACTR1A ACTR1B BRAFLDRAFT_127490 Syb lev-1 smyhc1 Slc6a8 nAChRalpha5 lev-8 nAChRalpha6 smyhc2 prt Stx16 nAChRalpha1 nAChRalpha3 Stx19 nAChRalpha2 Stx11 AgaP_AGAP002370 STX16 vamp8 STX19 STX11 chrna7a LOC100073534 snap25a snap25b CHRNA10 Myo9b Myo9a VIII-A PHYPA_016713 alm1 GL50803_0096994 cha-1 didum BRAFLDRAFT_127489 MYO9B CNA04650 MYO9A BRAFLDRAFT_127488 VIII-B PF14_0124 PHYPA_016711 spe-15 Act88F actc1b actc1a ACTG2 ACTG1 myo-2 myo-3 myo-5 myo-6 Os05g0438800 LOC103690878 myo-1 CHRNB2 zip CHRNB1 CHRNB4 CHRNB3 Os03g0747900 EHI_110180 MYH15 MYH16 mhcA MYH1B 4576836 MYH1G CHRNA1 eat-2 Mhcl CHRNA3 Act42A CHRNA2 CHRNA5 myhz1.2 BRAFLDRAFT_115291 myhz1.1 CHRNA4 CHRNA7 CHAT CHRNA6 CHRNA9 myh7 myh6 Myh11 CHRNA8 Myh14 myhz1.3 Myh13 Myh10 acr-11 acr-12 hum-1 BRAFLDRAFT_60743 myhc4 hum-2 v1g210933 hum-4 ChAT MYH13 Chat TRIADDRAFT_56111 hum-5 MYH14 hum-6 MYH11 hum-7 hum-8 MYH10 nSyb Actg1 Actg2 unc-63 unc-64 ninaC npp-21 BRAFLDRAFT_94959 Act79B 1272129 unc-54 nmy-3 WBGene00275837 snap-29 acta1b actr1 myhb myha PF3D7_1329100 MYO18B MYO18A Arp53D myo7aa acr-18 Myo61F acr-14 acr-17 AgaP_AGAP011138 acr-16 ACTA2 acta1a acr-2 MYH1 ACTA1 Myh1 MYH2 Myh2 acr-24 Myh3 MYH3 acr-3 act10 1281498 Myh8 MYH8 LOC100020439 MYH9 Myh9 acr-9 PF3D7_0103800 MYH4 acr-6 act18 Myh4 MYH6 Myh6 acr-8 MYH7 acr-7 Myh7 snb-1 chrna6 unc-38 SNC1 chrna1 lgc-8 lgc-9 act23 BRAFLDRAFT_56698 act22 WBGene00098673 Actc1 Actbl2 Syx4 Myo95E Act87E unc-29 myo1b Myo31DF ACTC1 MYO15B MYO15A BRAFLDRAFT_56687 nmy-2 nmy-1 SSO1 Actr1a SSO2 Actr1b myo52 Slc18a3 syx-16 Acta1 Acta2 myo51 SS1G_08733 myo3a psy1 BRAFLDRAFT_114958 SLC5A7 act-2 act-1 CTAGE4 DICPUDRAFT_48914 CTAGE9 SPCC18.02 act-4 act-3 act-5 XI-E BRAFLDRAFT_79607 GL50803_007309 TVAG_090470 XI-G XI-F stx1b XI-I XI-H XI-K XI-J MYO1 MYO2 XI-A stx1a XI-C XI-B BRAFLDRAFT_132597 myoE Myh7b myoD myoC MYO3 myoJ MYO4 myoI MYO5 myo6b MYO6 Myo6 MyoA myoK SNAP-25 MYH7B myo3 d ck NCU01440 myoB myoA ChT Snap29 ACT Snap24 SLC6A8 Act Snap25 Snap23 Os12g0163700 CHRFAM7A DICPUDRAFT_46519 LOC100027128 myo2 XI-1 myo1 XI-2 ACHE des-2 BRAFLDRAFT_125875 ro-4 act Tb09.211.0620 Syx16 SLC18A3 Ache Vamp8 Syx1A Vamp1 BRAFLDRAFT_125401 Vamp3 Vamp2 VAMP8 1273594 ache actin 1273596 EHI_110810 VAMP1 AgaP_AGAP000776 LOC100029767 Act57B VAMP2 PGTG_05488 VAMP3 syb1 TRIADDRAFT_49626 Os05g0106600 CHRND CHRNG UMAG_11232 CHRNE Stx4 STX4 Stx3 STX3 Stx2 STX2 syn-2 BCHE syn-1 Chrnd NOTCH SIGNALING PATHWAY%PANTHER PATHWAY%P00045 Notch signaling pathway glp-1 FUT8 NCSTN Fut8 gcn5 Rbpjl cir-1 1274578 dld JAG2 Jag2 jag1b Jag1 JAG1 jag1a fut8 Dmel\CG6843 At3g52640/At3g52650 Rbpj Dlk1 DLK1 num-1 NEURL4 NEURL2 aph-2 Lfng NEURL1 Lnx2 LNX1 LNX2 Lnx1 Su(H) lfng rbpja jag2b MAML1 ago sel-12 RBPJ sel-10 Adam17 LFNG 1275764 POFUT1 Mfng Adam10 lin-12 Numb Neurl1 CIR1 Neurl2 Neurl4 fng GCN5 Gcn5 Cir1 psen1 FBXW7 Dl ADAM10 lag-1 Psn Rfng numb Notch4 NCOR2 ADAM17 Notch1 MFNG Notch2 Notch3 NUMB Psen1 Pofut1 Nct NOTCH2 RBPJL hop-1 Ncstn NOTCH3 NOTCH1 Ncor2 NOTCH4 PSEN1 RFNG Dll1 DLL3 Dll3 DLL4 Dll4 O-ANTIGEN BIOSYNTHESIS%PANTHER PATHWAY%P02757 O-antigen biosynthesis gll1783 Tgds Gfpt1 PA3759 Gfpt2 SPBC12C2.11 CBG14085 YMR084W rfbB rffH TGDS wcaG rmlA DR_A0154 GFPT2 rfbA GFPT1 Gfat1 glmS-1 TM_0813 GFAT glmS-2 gfat-1 MA_4460 gfat-2 DR_A0031 rbfA rml-4 DR_A0367 YMR085W CBG03656 TM_0862 BT_0463 GFA1 BT_0466 glmM DR_A0041 Gfat2 LOC101733834 RHM3 DR_A0042 glmS RHM1 glmU RHM2 DR_0711 SPBPB2B2.11 glf SCO0749 bus-5 BT_2016 MA_2186 BT_2017 UNTITLED%PANTHER PATHWAY%P05916 untitled gnai2a gnai2b goa-1 gnb1 gnb2 Pdyn DICPUDRAFT_93216 gnai3 gnai1 gpb-2 gpb-1 PDYN gnaia Gbeta13F gnb1b BRAFLDRAFT_60318 Gng10 Gnao1 gsto1 Gbeta76C GNG10 8035476 Gnao Galphai BRAFLDRAFT_220697 nSyb Galphao SNAP-25 Gngt2 GNG12 Snap29 GNAO1 Snap24 Snap25 Snap23 GNB2 Gnb2 1276442 GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 gngt2a snap-29 SNAP23 Oxt OXT stx3b 1276578 1276579 git5 GNGT2 1276572 STE4 gnao1b Adcy2 Adcy7 Syb SNAP29 Vamp8 sfaD SNAP33 1276580 Vamp1 oxt SNAP30 Vamp3 Vamp2 SS1G_03482 VAMP8 gnb5b GB1 Gnai2 gnb5a VAMP1 Gnai1 Avp AVP VAMP2 Gnai3 VAMP3 snb-1 CND03830 syb1 ric-4 vamp8 GNAI3 vamp2 CiGi1 ADCY2 SNC2 ADCY7 GNAI1 GNAI2 SNC1 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 1281784 Gng7 snap25a GNG8 snap25b Gng8 avp Stx3 STX3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 OPRK1 gnb3b gnb3a gpbA Oprk1 aex-4 OPIOID PROENKEPHALIN PATHWAY%PANTHER PATHWAY%P05915 Opioid proenkephalin pathway gnai2a gnai2b gnb1 gnb2 Pdyn Oprd1 DICPUDRAFT_93216 gnai3 gnai1 gpb-2 gpb-1 PDYN gnaia Gbeta13F gnb1b BRAFLDRAFT_60318 Oprm1 Gng10 gsto1 Gbeta76C GNG10 8035476 Galphai PENK BRAFLDRAFT_220697 nSyb SNAP-25 Gngt2 penkb GNG12 Snap29 Snap24 Snap25 Snap23 GNB2 Gnb2 penka GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 gngt2a snap-29 SNAP23 stx3b 1276578 1276579 git5 GNGT2 1276572 STE4 Adcy2 Adcy7 Syb SNAP29 Vamp8 sfaD SNAP33 1276580 Vamp1 SNAP30 OPRM1 Vamp3 Vamp2 SS1G_03482 VAMP8 gnb5b Penk GB1 Gnai2 gnb5a VAMP1 Gnai1 VAMP2 Gnai3 VAMP3 OPRD1 snb-1 CND03830 syb1 ric-4 tmem26 vamp8 GNAI3 vamp2 CiGi1 ADCY2 SNC2 ADCY7 GNAI1 GNAI2 SNC1 GNG3 Gng3 1281667 GNG2 Gng2 GNG5 Gng5 Gng4 GNG4 GNG7 1281784 Gng7 snap25a GNG8 snap25b Gng8 Stx3 STX3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 gnb3b gnb3a gpbA aex-4 OPIOID PROOPIOMELANOCORTIN PATHWAY%PANTHER PATHWAY%P05917 Opioid proopiomelanocortin pathway gnai2a gnai2b goa-1 gnb1 gnb2 Oprd1 DICPUDRAFT_93216 gnai3 gnai1 gpb-2 gpb-1 gnaia Gbeta13F gnb1b BRAFLDRAFT_60318 Oprm1 Gng10 Gnao1 gsto1 Gbeta76C GNG10 8035476 Gnao Galphai BRAFLDRAFT_220697 nSyb Galphao SNAP-25 Gngt2 GNG12 Snap29 GNAO1 pomca Snap24 Snap25 pomcb Snap23 GNB2 Gnb2 1276442 GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 ANIA_08769 Gng12 SNAP25 gngt2a snap-29 SNAP23 stx3b 1276578 1276579 git5 GNGT2 1276572 STE4 gnao1b Adcy2 Adcy7 Syb SNAP29 Vamp8 sfaD SNAP33 1276580 Vamp1 OPRM1 SNAP30 Vamp3 Vamp2 SS1G_03482 VAMP8 gnb5b GB1 Gnai2 gnb5a VAMP1 Gnai1 VAMP2 Gnai3 VAMP3 OPRD1 snb-1 CND03830 syb1 ric-4 vamp8 GNAI3 vamp2 CiGi1 ADCY2 SNC2 ADCY7 GNAI1 GNAI2 SNC1 GNG3 Gng3 1281667 GNG2 Gng2 Pomc GNG5 Gng5 Gng4 GNG4 GNG7 1281784 Gng7 snap25a GNG8 snap25b Gng8 STX3 Stx3 gnb-1 gng2 Gbeta5 gng3 gng5 gng7 POMC gnb3b gnb3a gpbA aex-4 ORNITHINE DEGRADATION%PANTHER PATHWAY%P02758 Ornithine degradation CELE_F53F10.2 SNOG_03643 AgaP_AGAP012308 YALI0_B11330g AZIN2 LMJF_12_0280 MA_2728 AZIN1 speC odc1 1280840 SCO4113 patD Tb11.01.5300 SCO6035 Azin2 PF3D7_1033100 spe1 Azin1 Odc2 azin1b spe-1 AgaP_AGAP011807 Odc1 AgaP_AGAP011806 ODC1 TM_1873 lhgD SPE1 gll2207 odc-1 RB10062 OXIDATIVE STRESS RESPONSE%PANTHER PATHWAY%P00046 Oxidative stress response Mapk9 Mapk8 C16A3.2 Elk1 ELK1 C04F12.8 Map3k4 PHS1 Myc MYC MAP3K4 p38b p38a MAP2K3 MEF2A MAP2K4 MEF2C Dusp26 Dusp28 Mkp3 Ddit3 Txndc2 CELE_F26A3.4 pla2g4a DSPTP1 DDIT3 NCU06556 1277751 myca bsk mef2ca Dusp21 Dusp22 PF14_0545 Max MAX Os01g0347000 mapk14a Styx Txn TXN lip-1 DDB0169455 mapk14b MAP2K6 dhd Jun JUN Eef2k max STYX CELE_F13D11.3 stat1a Trx-2 pmk-2 Dmel\CG15528 pmk-1 Os01g0390900 Mkp Dmel\CG13473 BCL2 Bcl2 trx-4 mapk12 trx1 jnk-1 mknk1 CBG03773 DUSP19 Pla2g4a DUSP18 DUSP15 DUSP16 map2k4a vhp-1 DUSP13 DUSP14 AgaP_AGAP012237 DUSP12 DUSP10 EEF2K Styxl1 mknk2b PF3D7_0309000 yvh1 DUSP4 DUSP5 DUSP2 DUSP3 mapk8 DUSP1 PLA2G4B PLA2G4A DUSP29 DUSP26 DUSP8 DUSP9 DUSP27 DUSP6 DUSP7 DUSP22 efk-1 DUSP21 XENTR_v90029485mg Dusp13 Dusp14 Dusp16 Dusp18 Dusp19 CBG00285 STYXL2 Map2k6 Dusp3 png-1 MAPK9 Dusp2 MAPK8 Dusp5 Dusp4 Dusp1 MKNK1 MKNK2 MKP1 Dusp7 mef-2 Dusp10 Dusp6 Dusp9 Dusp8 Dusp12 Mapk12 CELE_Y54F10BM.13 Mapk13 Mapk14 STAT1 C24F3.2 MAPK14 MAPK12 MAPK13 YVH1 Map2k4 MAPK10 TRX1 dusp6 Map2k3 Dusp14l1 MAPK11 Mef2a Mef2c Mknk2 1278949 Mknk1 MKP-4 Stat1 Mapk11 TRX2 puc OXYTOCIN RECEPTOR MEDIATED SIGNALING PATHWAY%PANTHER PATHWAY%P04391 Oxytocin receptor mediated signaling pathway VAMP3 syb1 prkchb CND03830 vamp8 vamp2 Pkc98E Plcd1 Plcd4 Plcd3 1281667 1281784 snap25a snap25b Stx3 STX3 1270776 gnb-1 Gbeta5 NCU02175 Plce1 gpbA PLCD3 PLCD4 aex-4 PLCD1 gnb1 gnb2 prkcbb prkcba AgaP_AGAP002748 DICPUDRAFT_93216 plc1 pkc-1 pkc-2 pkc-3 egl-30 prkcda plcd1b Gbeta76C 8035476 Gnaq 1281188 nSyb tpa-1 gnaq PLC4 PLC3 PLC5 PLC2 PLC1 PLC8 PLC7 GNB2 Gnb2 GNAQ GNB1 Gnb1 PLC9 GNB4 Gnb4 GNB3 Gnb3 GNB5 Gnb5 ANIA_08769 SNAP25 Gnaq1 gngt2a snap-29 SNAP23 aPKC stx3b plc-2 plc-3 1276578 plc-4 1276579 PLCZ1 plc-1 SNAP29 Os07g0694000 sfaD SNAP33 1276580 SNAP30 gnb5b gnb5a Gna11 snb-1 ric-4 Gna14 pll-1 SNC2 SNC1 GNA14 GNG3 Gng3 GNG2 Gng2 GNG5 Plcl2 Gng5 Plcl1 GNG4 Gng4 GNG7 GNA11 inaC Gng7 Gng8 GNG8 gng2 gng3 gng5 PLCL1 plc PLCL2 gng7 gnb3b gnb3a OXTR oxtr PLCE1 Plc21C norpA PRKCG gpb-2 PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD Plcg1 Pkcdelta PRKCA Pkc53E Prkcq Plcg2 Prkcg Prkch Gbeta13F gnb1b Prkci Prkcb Prkcd Prkce PRKCQ Prkca Gng10 Plch1 PRKCZ GNG10 gna11b BRAFLDRAFT_220697 PLCG2 sl PLCG1 Galphaq Prkcz SNAP-25 Gngt2 Oxtr Plcz1 GNG12 Snap29 Snap24 Snap25 Snap23 AgaP_AGAP012252 Gng12 Plcb4 Plcb3 prkcq egl-8 plcg1 Plcb2 Plcb1 prkci git5 GNGT2 STE4 prkcb AgaP_AGAP009115 Syb Vamp8 Vamp1 Vamp3 Vamp2 SS1G_03482 VAMP8 PLCB3 PLCB4 GB1 VAMP1 PLCB1 PLCB2 VAMP2 P38 MAPK PATHWAY%PANTHER PATHWAY%P05918 p38 MAPK pathway SRF Srf Gadd45a Mef2d Map2k6 CDC42 Dusp1 MKNK1 rac3a MKNK2 rac3b mapk14b Hspb1 MEF2D EIF4E Dusp10 MAP2K6 Mapk12 Mef2 Mapk13 Mapkapk3 Mapk14 Mapkapk2 Eef2k GADD45A MAPK14 MAPK12 MAPK13 Map2k4 MAPK11 Mef2a Mef2b Borcs8 Mef2c Mknk2 MAP3K10 Mknk1 TAB2 Tab2 Map3k10 Tab1 TAB1 Il1r1 mapk12 Mapk11 ATF1 cRac1A Atf1 cdc42 Traf6 HSPB1 Elk1 Map3k7 ELK1 Map3k5 Map3k4 RPS6KA4 rac1b DUSP10 EEF2K RPS6KA5 RAC2 Rac2 MAP3K7 MAP3K4 MAP3K5 MEF2A MAP2K3 MAP2K4 MEF2C MEF2B IL1R1 DUSP1 Eif4e efk-1 Rps6ka4 Rps6ka5 CREB1 eif4e MAPKAPK3 TRAF6 MAPKAPK2 BRAFLDRAFT_122664 P53 PATHWAY BY GLUCOSE DEPRIVATION%PANTHER PATHWAY%P04397 p53 pathway by glucose deprivation PRKAG1 S6k BRAFLDRAFT_123893 tp63 8041094 akt3b Igbp1 STK11 Prkaa1 Prkaa2 Akt3 AKT2 AKT3 Akt2 Akt1 DICPUDRAFT_91511 AKT1 let-92 1269396 Tp53 TP63 SKP1 Ppp2cb Ppp2ca rps6kb1b PRKAB2 akt-1 Tsc2 TSC2 TSC1 Tsc1 tp53 PRKAB1 mts v1g195622 Tor TP53 stk11 PRKAA1 PRKAA2 akt2 Eif4ebp1 PPP2CA PPP2CB pph-1 Rps6kb1 Rheb Rps6kb2 EIF4EBP1 ppp2cab ppp2caa ppp2cb Prkag1 Tp73 prkaa1 IGBP1 TRIADDRAFT_63380 pphA Stk11 1279592 tp73 RPS6KB1 Prkab2 RHEB RPS6KB2 Prkab1 pho2a Tp63 TP73 P53 PATHWAY FEEDBACK LOOPS 1%PANTHER PATHWAY%P04392 P53 pathway feedback loops 1 cop1 tp53 Cop1 tp73 tp63 mdm2 COP1 Mdm2 MDM2 MDM4 Mdm4 TP53 Tp53 TP63 Tp63 Tp73 TP73 P53 PATHWAY FEEDBACK LOOPS 2%PANTHER PATHWAY%P04398 p53 pathway feedback loops 2 hrasb TPTE hrasa DAPPUDRAFT_301818 PPP2CA PPP2CB NRAS ppp2cab Kras ppp2caa pikA ppp2cb Mapk12 Rb1 Mapk13 Mapk14 Pi3K21B pik3ca Pten kras MAPK14 pphA 1279592 MAPK12 MAPK13 MAPK11 AgaP_AGAP010273 CCNG1 E2f1 CTNNB1 Stat1 LOC685590 KRAS Cdkn1a Hras PTEN2A Mapk11 RB1 PKH2 PKH1 PKH3 Ccne1 DGKA Ctnnb1 vps-34 BRAFLDRAFT_123893 tp63 akt3b Myc AKT2 MYC Akt3 Akt2 AKT3 Akt1 AKT1 let-92 VPS34 1269396 Tp53 TP63 p38b SKP1 Pdk1 Ppp2cb ksg1 Pi3K59F Ppp2ca akt-1 Tpte tp53 Nras ptena CCNE1 v1g195622 myca TP53 tel1 ctnnb1 mei-41 mapk14a ctnnb2 PIK3R3 Pi3K92E PIK3R2 PIK3R1 PIK3R5 siah1 pph-1 ANIA_06975 mapk14b Pik3cg ccne1 Pik3cb arm Pik3cd Tp73 Pik3ca age-1 cdk2 SIAH1 Pik3c2b stat1a AgaP_AGAP011036 TRIADDRAFT_63380 Pik3c2a Pik3c2g tp73 zgc:55558 Siah1 CDK2 ATM Atm mapk12 pho2a Atr Tp63 TP73 ATR Ccna1 Ccna2 CDKN1A PTEN PIK3CD PIK3C2G PIK3CB rad3 PIK3C2A Pik3c3 PIK3CG PIK3C2B 8041094 Pdpk1 e2f3 DICPUDRAFT_91511 pten HRAS PDPK1 rasA vps34 PTEN1 mts OSJNBb0008G24.23 CCNA2 CCNA1 TEL1 RBL1 Rbl1 PIK3CA ppk21 pteN Siah1b PIK3C3 Siah1a AgaP_AGAP000018 1269341 let-60 Pik3r1 Pik3r2 Pik3r3 Pi3K68D daf-18 MEC1 pikB nras pikC akt2 Ccng1 pikE P53 PATHWAY%PANTHER PATHWAY%P00059 p53 pathway pik3ca CRK2 Pten Gtse1 1279592 PML Pml cbp-1 cbp-3 E2f1 LOC685590 Cdkn1a sumo3l PTEN2A PKH2 PKH1 PKH3 Ccne1 DGKA BRAFLDRAFT_123893 tp63 mdm2 akt3b CHEK2 AKT2 Akt3 Akt2 AKT3 Akt1 Hmg1l1 EP300 AKT1 cycB 1269396 Tp53 GTSE1 TP63 HAC12 Cdkn2d SKP1 Pdk1 Ppp2cb ksg1 Ppp2ca HAC1 akt-1 gadd45aa HAC2 HAC5 Tpte HAC4 tp53 CDC25C KAT6B CCNE1 v1g195622 Sirt1 hdac1 gadd45g UMAG_02065 ccnb1 TP53 Cdc25c Cdc25a tel1 mei-41 Chek2 CCNB1 ANIA_06975 Hmgb1 SFN Sfn ccne1 Tp73 Tb927.7.7360 CREBBP Pik3ca chek2 GADD45B GADD45A cdk2 cdk1 TRIADDRAFT_63380 CDKA-2 tp73 GADD45G Crebbp CycB CDK2 Cdk2 CDK1 MDM2 Cdk1 Mdm2 Mdm4 MDM4 ATM Atm Atr Tp63 cdc2 TP73 ATR CDKN1A Sin3a Traf6 PTEN HMGB1 rad3 8041094 Hdac1l SUMO1 Pdpk1 e2f3 SIN3A Hdac1 SUMO3 SUMO2 pten Traf2 MTA1-like Ccnb1 sumo3 PDPK1 sumo2 sumo1 LOC108350839 PTEN1 TRAF2 SIRT1 mts OSJNBb0008G24.23 KAT2B TEL1 PIK3CA ppk21 pteN Tb10.70.2210 daf-18 MEC1 HDAC2 Gadd45g Sumo1 HDAC1 akt2 Sumo2 Sumo3 Gadd45b Ep300 Gadd45a TPTE PPP2CA PPP2CB WRN Wrn ppp2cab ppp2caa MTA2 Mta2 ppp2cb LOC298795 Kat2b CDKN2D sin3a CDKN2A PANTOTHENATE BIOSYNTHESIS%PANTHER PATHWAY%P02761 Pantothenate biosynthesis pan-4 apbA ECM31 panB panC panD BT_0735 aq_1727 PAN6 panE PAN5 KPHMT1 PANC panC/cmk SPAC5H10.09c YDL144C SPBPB2B2.09c KPHMT2 pan6 panD1 panD2 SCO0462 SCO6562 RB3312 pan-2 ykpB PARKINSON DISEASE%PANTHER PATHWAY%P00049 Parkinson disease UMAG_03305 UMAG_01366 Elk1 ELK1 GRF10 GRF11 WBGene00115054 ube2l3a Psmb10 p38b DAPPUDRAFT_223674 ywhaz CSNK2A1 CSNK2A3 CSNK2A2 PHYPA_003021 hspB SPAC13C5.01c Sncg Ube2l6 Sncb DAPPUDRAFT_305830 Ube2l3 Snca ywhab AgaP_AGAP010876 RPN9 par-5 Hsc70-4 Hsc70-5 CNL03930 PHYPA_010924 mapk14b ftt-2 SFN v1g161273 Sfn Hsc70-2 LOC_Os03g16860 Hsp70Ba LOC709412 Hsc70-3 Hsc70-1 LYN Lyn CKIalpha bip1 hspa8b bip2 SS1G_05445 1274027 BIP3 spk1 BIP2 BIP1 Os05g0460000 rpn9 hsc70 pbs-2 pbs-3 Psma4 Psma3 Psma6 Psma5 EHI_004760 TVAG_044510 LOC_Os11g47760 Psma2 Psma1 Csnk2a2 Csnk2a1 SLC6A3 Prosbeta2R1 Psmb7 GPR37 csnk1da Psmb1 Psmb3 Os07g0114400 CK2B csnk1db CK2A hsp70.3 AGOS_AGR107C pca-2 PHYPA_005007 PSMA5 Gpr37 PSMA6 1275771 PSMA3 Tb11.02.5170 PSMA4 PSMA1 PSMA2 TVAG_237140 Psma8 YALI0_D16863g 1276625 Psma7 hsp-6 DAPPUDRAFT_301140 hsp-4 hsp-3 hsp-1 CK1 Csnk1a1 LOC_Os03g60620 PSMA7 PSMA8 PSMB7 PSMB3 HRR25 PSMB1 Tb11.01.3110 PPP1R8 SPBC2G5.02c Sncaip hsp-70 HSPA1L SEPTIN1 SEPTIN2 CSNK1A1 SEPTIN5 SEPTIN4 SCO4566 SNCAIP EHI_006810 OsPBB1 DICPUDRAFT_92891 ANIA_02062 1275676 GL50803_0014497 mpk-1 cka Ube2j2 FRK Frk HSPA1B nuo-24 HSPA1A AgaP_AGAP009207 TOR2A PHYPA_014428 1277104 csnk1a1 Tor1a 1276254 Src64B cul1 TVAG_161100 CSNK1G3 PHYPA_014678 FBXW7 CELE_F44E5.4 STX7 Stx7 dnaK1 Src42A dnaK2 Fbxw11 dnaK3 Prosbeta2 Prosbeta3 Tor2a GF14A SS1G_11866 CEK1 PF3D7_0818900 BRAFLDRAFT_113587 CSNK1G2 EHI_199590 Blk BLK EHI_025360 PHYPA_018927 CUL1 GF14C GF14B GF14D GF14G mcm5 GF14F CkIIbeta2 TVAG_137250 8032886 LMJF_35_1730 ccne1 TVAG_184320 ND-24L TOR1A v1g245041 DAPPUDRAFT_307391 culA nfh-2 DAPPUDRAFT_326737 PF3D7_1134000 syx-7 Ndufv2 DICPUDRAFT_49867 CkIIbeta 1279677 Cul1 jnk-1 PBB1 KSS1 PBB2 HSP70-18 nuoE Csnk1g3 Csnk1g1 Csnk1g2 Dmel\CG9962 HSP70-10 LMJF_28_2770 LMJF_28_1200 Csnk2b mapk8 psma6a mapk3 chn-1 psma6l mapk1 1278761 LCK Lck At3g13670 ckb-2 ckb-1 Csnk1d Csnk1e Hsp70Aa TVAG_206270 pre8 PAB2 PAB1 Src EHI_052860 SRC pre6 hsp70l LOC479459 Prosbeta7 CKL10 WBGene00094756 ND-24 lin-2 CKL13 KAR2 CKL12 FYN Fyn CSK PAC1 Csk Tb10.100.0120 Mapk12 Mapk14 Mapk15 PAA1 PBC2 PAA2 TM_1424 Os01g0570500 Stub1 1276122 DICPUDRAFT_48337 Os02g0634900 fyna fynb YCK2 ugt1a1 Hsp70Bbb Tb10.70.0850 csnk2a2a csk STUB1 YCK3 Mapk10 14-3-3zeta Tb11.01.3080 psmA7 At4g08800 LOC745166 Dmel\CG2577 MPK4 MPK5 UBE2L6 MPK6 Hsp68 MPK7 UBE2L5 MPK1 1278270 TVAG_300470 MPK2 At3g03940 UBE2L3 MPK3 TVAG_163000 CSNK1B MPK8 MPK9 Os01g0840100 PAE1 PBG1 Tb927.7.4420 1272856 psma8 ECM10 Os02g0182500 mpkB Mut9 CSNK1D csnk2b CSNK1E GPR37L1 ywhaba 5667763 PRE8 PRE9 PRE6 CSNK2B csnk1d PRE5 psmb1 PAD2 psmA1 dnaK PAD1 bsk psmb3 psmA3 psmA4 psmb7 Tb927.6.3740 14-3-3epsilon UBE2J2 F53F4.10 HSP70A DR_1501 SSA3 SSA4 Os07g0495100 SSA1 SSA2 HSP70B ckb1 psma1 LMJF_30_2470 psma2 pre10 psma4 PAG1 psma5 YES1 kin-3 Yes1 CKA4 CKA3 CKA2 8041862 TM_0012 ssa1 HSP70.4 ssa2 BMH2 BMH1 PF3D7_0803800 PHYPA_000697 hsps-1 TH 1281478 cka1 PAF1 5667627 ywhae1 LMJF_30_2460 ywhae2 CkIIalpha HSP70-1 PUP2 PUP1 HSP70-5 CKB4 HSP70-4 CKB3 CKB2 HSP70-3 SSC1 CKB1 B1046G12.17-1 HSP70-9 HSP70-7 erkB PUP3 Prosalpha4T1 UCHL1 Prosalpha4T2 hspa8 Th hspa5 LOC_Os03g10940 LMJF_30_2490 hsp70_4 Tb11.02.4870 Slc6a3 TVAG_151220 SPBC577.10 Septin5 Septin4 PAC1A Septin2 SSB1 Septin1 kin-10 SPAC6G10.04c Stx12 HCK Hck Prosalpha1 ttbk-7 pup1 Prosalpha2 pup2 Prosalpha3 Fbxw7 Prosalpha4 Prosalpha5 Prosalpha6 SSB2 Prosalpha7 ssc1 ywhag1 Tb10.100.0170 ywhag2 Adrbk2 1269582 pup3 PRKN STX12 DICPUDRAFT_26270 Hspa1b Hspa1a 1278250 SYP23 SYP22 Hspa1l SYP21 kin-19 CBG13234 SYP24 LMJF_04_1210 zeta Uchl1 ubc-18 LMJF_21_1830 hhp1 hhp2 GRF2 LOC_Os10g41520 GRF3 GRF6 GRF5 GRF8 Tb09.211.2590 Tb09.211.4890 GRF9 Mapk9 Mapk7 LOC_Os03g55490 Mapk8 Ccne1 Ccne2 Mapk1 1282015 LMJF_21_1700 Mapk3 CBG11518 mak-2 PHYPA_000704 Tb927.4.430 LMPK Tb10.6k15.2790 Prkn MPK20 FBXW11 CASK Ubc84D Ubc10 GL50803_17121 CCNE2 CCNE1 Os01g0772600 casK 1273316 1269385 1269384 MPK10 MPK13 Cask MPK14 MPK11 MPK18 MPK15 MPK16 PLD2 Pld2 GRK3 MPK19 Grk2 GRK2 8036204 NDUFV2 SS1G_12241 HSPA9 HSPA8 rad24 grk3 HSPA5 mapk10 grk-2 grp78 HSPA6 HSPA2 rad25 DICPUDRAFT_44981 FUS3 PRE10 Os01g0254900 Hspa8 Hspa9 Gprk1 Dmel\CG7094 Hspa5 PF3D7_0818200 DICPUDRAFT_52118 CkIalpha Hspa2 1275756 cki3 cki1 cki2 YWHAE Os06g0167600 EHI_098280 psmb13a YWHAB CrMPK2 Ywhaq Ubc7 FTT1 Ywhah PF3D7_0917900 Ywhag YALI0_D00737g Tb927.3.780 GL50803_0088765 pas-4 pas-5 Ywhae pas-6 SCL1 YWHAQ Prosalpha6T 1281126 Ywhab pas-1 YWHAG YWHAH pas-2 cul1b cul1a tor-2 fttB YWHAZ SEPT5 tor-1 FGR Fgr LMJF_35_4850 Tb11.02.5450 ube2l3 ANIA_04501 Ywhaz hog1 AgaP_AGAP001683 Dmel\CG5823 TVAG_340390 mapk-15 CKL8 CKL7 CKL6 CKL5 PSMB10 CKL4 CKL3 CKL2 MAPK9 dco MAPK8 MAPK7 zgc:86598 SNCG MAPK1 spe-6 PHYPA_010689 SNCB LOC298795 LMJF_30_2550 LMJF_35_1010 MAPK3 SNCA SPBC646.16 Gpr37l1 csnk-1 MAPK14 MAPK15 MAPK12 MAPK10 sept2-B bcl2l11 SNOG_03299 Prosalpha3T LMJF_35_1000 CSNK1A1L ANIA_01019 PDGF SIGNALING PATHWAY%PANTHER PATHWAY%P00047 PDGF signaling pathway gsk3bb Rab11b fli1 ksg1 Plcg1 Araf PRKCA Plcg2 Arhgap6 Arhgap5 Arhgap4 Arhgap1 Prkca Arhgap8 PDGFB PDGFA bs prk-1 shc-1 PLCG2 Pdgfa Pdgfb PLCG1 braf STARD13 JUN Jun CELE_W04B5.5 grb2a grb2b BRAF Dsor1 FLI1 Fli1 Stat5a Stat5b gsk3ab Ehras1 RhoGAP16F ARHGAP9 Ikbkb ARHGAP8 Stat6 Stat4 RAS2 ARHGAP1 CELE_F11A5.4 Braf RAS1 ARHGAP5 ARHGAP6 ptgfr CELE_F11A5.3 ARHGAP4 Shc IKBKB rasD rasG PF3D7_0312400 mek-2 rasS itpr1 Jak3 JAK2 Jak2 NINL JAK3 Jak1 JAK1 vav-1 rasA rasC SIRT6 FOS rasB Fos jak1 Spdef OSJNBb0008G24.23 Itpr CBG07560 Ets97D ras1 1273239 unc-120 Pik3r1 Pik3r2 Pik3r3 pikB nras pikC pikE hrasb hrasa NRAS STAT4 STAT6 pikA JAM2 SPDEF ASK7 ASK8 ASK5 ASK3 STAT1 Grap2 ASK4 STAT2 ASK1 STAT3 ASK2 ELP1 Elp1 cRhoB Stat3 Stat2 Pkn2 Stat1 PKN2 LOC685590 S6kII Rps6kl1 rga-6 rga-1 rskn-1 Map3k4 Eip74EF 1280872 GRAP2 MAP3K4 ASK9 MAP2K1 MAP2K2 Map3k2 RIM11 Nras SS1G_13801 Tor SS1G_11866 MAPKAPK2 CEK1 ERF Erf ERG Erg Shc3 SHC2 Shc2 SHC3 RGD1 Shc1 SHC1 ITPR1 ITPR2 NCU06500 ITPR3 sta-1 LOC100012174 Pdgfrb Pdgfra Pdgfrl SRGAP3 SRGAP2 SRGAP1 1272910 JIL-1 v1g247341 stat1a CELE_T04C9.1 itr-1 Sos lin-45 CiGSK rab11ba rab11bb Itpr3 Itpr2 Itpr1 jak2a mknk1 AgaP_AGAP006475 PIK3CD PIK3CB PIK3CG NCK2 srgp-1 Nck2 drk Arhgap10 NCK1 Nck1 Arhgap15 Arhgap12 CHUK nck1 mapk3 mapk1 PIK3CA Os01g0252100 Ets21C PIK3C3 SOS1 let-60 Sos2 SOS2 Sos1 Arhgap26 SRF Srf sem-5 Arhgap27 gefA gefB gefE Mapk15 pdgfaa pik3ca Nin NIN Chuk Mapk10 Arhgap42 grb2 MPK1 MPK2 RPS6KA4 RPS6KA3 RPS6KA6 RPS6KA5 MPK8 OPHN1 MPK9 RPS6KA2 RPS6KA1 EPHB2 Pdk1 gefY mpkB ast-1 pnt gefP gefR Rasa1 At2g14045 PIK3R3 PIK3R2 Pi3K92E PIK3R1 PIK3R5 Graf Rps6kb1 Rps6kb2 sl Grap psk1 STAT5A STAT5B RPS6KA pck2 Stard8 LOC100011470 GRB2 Grb2 GRAP gsk31 pdk-1 erkB Pik3c3 Gabpa LOC_Os10g37740 tag-325 HRAS Pk34A GABPA VAV3 Vav3 PDGF-A MAPk-Ak2 Gab1 GAB1 GAB2 Gab2 VAV1 Vav1 Vav2 VAV2 RHOB 1269341 ras-1 MYCBP Ophn1 DAPPUDRAFT_301818 Mycbp raf1a stat3 CSN5B MAP3K2 stat4 stat5b stat5a RAB11B Map2k2 Map2k1 DLC1 Dlc1 Hras Mapk7 Srgap1 Mapk8 Srgap2 Srgap3 gsk-3 Mapk1 Vav AgaP_AGAP011463 Ets1 Mapk6 ETS1 Mapk3 Mycb srfA mak-2 ARHGAP42 gskA Ras85D PDGFRB PDGFRA ets1 vap MPK20 gsk3 PDGFRL LOC521224 mycb myca RAF1 Raf1 MKK2 ARHGAP15 MPK18 MPK15 ARHGAP12 MPK16 MPK19 Pik3cg Pik3cb Pik3cd gabpa Pik3ca mapk10 gskt srgap1b ARHGAP26 Fev FEV Stat92E RhoGAP68F GSK3B GSK3A Prr5 RasGAP1 RERG plc-3 Pdpk1 Rasal1 RASA4B PDPK1 Etv2 ETV2 ETV3 PKC1 Etv3 Gsk3b Rps6ka3 Rps6ka4 ARHGAP10 AgaP_AGAP010292 ELF1 Elf1 Elf2 ELF2 Gsk3a ELF3 Elf3 Elf4 ELF4 RASA4 RASA1 Elf5 ELF5 Rps6ka1 RASA2 Rps6ka2 fosab AgaP_AGAP000018 rsks-1 akt2 LOC100490096 C44H4.6 MAPK8 MAPK7 RPS6KC1 MKNK1 MKNK2 MAPK1 MAPK6 MAPK3 Usf2 Mapkapk2 kras USF2 MAPK15 Rerg MAPK10 RPS6KB1 Raf Stard13 RPS6KB2 Mknk2 Mknk1 KRAS SNOG_03299 PKH2 PKH1 EHF Ehf PKH3 RhoGAPp190 ARAF Elk1 ELK1 Os01g0296100 ELK4 Elk4 AKT2 MYC Myc Akt2 gsk3ba VPS34 PENTOSE PHOSPHATE PATHWAY%PANTHER PATHWAY%P02762 Pentose phosphate pathway HK1 Rpia pgi YLR446W araD gnd tal araB Hkdc1 RKI1 MPF21.15 prk TALDO1 PGD Pgd Hk2 Hk1 RPIA tktA GND1 HKDC1 TKL1 Tkt TKT fsaB GPI rpiA Taldo1 Hex-A Rpi HK2 T19F6.14 PEPTIDOGLYCAN BIOSYNTHESIS%PANTHER PATHWAY%P02763 Peptidoglycan biosynthesis racE murA murE cphA DR_1076 ykoN SCO1126 murD murB murI murB2 ddl murG SCO1018 At1g73740 yrpC ddlB LA_2699 glr3229 ugtP ddlA MURE PHENYLALANINE BIOSYNTHESIS%PANTHER PATHWAY%P02765 Phenylalanine biosynthesis CM1 aroH ARO7 aspC CM3 CM2 SCO3962 SCO1762 PHA2 DR_1147 BT_3936 aro7 NCU07725 ADT5 gll0524 ADT6 ADT3 glr2705 ADT4 pha2 ADT2 pheA tyrB TM_0155 PHENYLETHYLAMINE DEGRADATION%PANTHER PATHWAY%P02766 Phenylethylamine degradation MHK10.21 Aoc3 Doxl2 Aoc2 AOC1 AOC2 Aoc1 AO1 F23N14_50 Svs1 At1g31672 G6pc1 tynA cao1 cao2 feaB At4g12280 At4g12290 At4g12270 LOC100138645 AOC3 Doxl1 PHENYLPROPIONATE DEGRADATION%PANTHER PATHWAY%P02767 Phenylpropionate degradation hsaF mhpE SCP1.53c PI3 KINASE PATHWAY%PANTHER PATHWAY%P00048 PI3 kinase pathway GNA14 NRAS GNA11 Inppl1 gnb-1 Gbeta5 Gnat2 Casp9 NOS2 Nos3 NOS3 Nos2 pik3ca Pten kras RPS6KB1 RPS6KB2 gpbA LOC685590 14-3-3zeta gnai2b IRS1 Irs1 gnb1 gnb2 INPPL1 akt3b GNAT2 AKT2 Akt3 Akt2 AKT3 Akt1 AKT1 DICPUDRAFT_93216 gnai3 gsk3ba gnai1 gsk3bb gpb-2 gpb-1 ywhaz akt-1 gnaia Gbeta13F gnb1b Nras egl-30 BRAFLDRAFT_60318 daf-2 Inpp5a Insr PIK3R3 Pi3K92E PIK3R2 PIK3R1 gsto1 FOXO4 FOXO3 FOXO1 PIK3R5 Gbeta76C INPP5A 8035476 Galphai Rps6kb1 Rps6kb2 gna11b Gnaq BRAFLDRAFT_220697 ftt-2 Pik3cb Gngt1 Gngt2 Pik3ca INSR grb2a gnaq grb2b ipp-5 5PtaseI GNB2 Gnb2 GNAQ GNB1 Gnb1 GNB4 Gnb4 Gnb3 GNB3 GNB5 Gnb5 GSK3B pdk-1 GSK3A RAS2 PTEN RAS1 PIK3CB GNGT1 CASP9 1276578 1276579 git5 GNGT2 Pdpk1 Ptger3 rasD Ptger1 pten Foxo4 JAK2 Jak2 Foxo3 Foxo1 sfaD PDPK1 1276580 InR YWHAZ SS1G_03482 Gsk3b chico PIK3CA GB1 Gnai2 ras1 gnb5a pteN Gnai1 let-60 SOS1 Sos2 1269582 ras-1 Pik3r1 Sos1 SOS2 Pik3r2 Ywhaz Gnai3 Gna11 daf-18 CND03830 nras PTGER1 akt2 Gna14 sem-5 GNAI3 hrasb CiGi1 hrasa GNAI1 GNAI2 PLASMINOGEN ACTIVATING CASCADE%PANTHER PATHWAY%P00050 Plasminogen activating cascade CPB2 SERPINE1 Plg PLG PLAT PLAU Serpinf2 Serpinb2 FGB Fgb FGA Fga Mmp13 SERPINB2 MMP1 Fgg SERPINF2 MMP3 FGG Mmp3 PLAUR Plat Mmp8 MMP9 MMP13 Plau Serpine1 Plaur LPA Cpb2 PROLINE BIOSYNTHESIS%PANTHER PATHWAY%P02768 Proline biosynthesis proB proA2 proA1 proJ YHR033W SPAC17H9.13c proA pro1 PRO2 PRO1 PRPP BIOSYNTHESIS%PANTHER PATHWAY%P02760 PRPP biosynthesis yhfW deoB drm PURINE METABOLISM%PANTHER PATHWAY%P02769 Purine metabolism amdA NCU09621 GDA Gda Pnp2 ry AMD1 AMPD3 LMJF_13_0980 hxA NT5E Pnp PNP Nt5e Ampd3 PA1521 PA0134 Xdh XDH PA3004 AMPD PYRIDOXAL-5-PHOSPHATE BIOSYNTHESIS%PANTHER PATHWAY%P02759 Pyridoxal-5-phosphate biosynthesis PNPO 1269333 psat1 DXPS3 dxs2 dxs1 dxs F26H9.5 EhPSAT PPOX1 SPAC1093.02 CG11899 PDX3 CBG22021 pdxH PSAT2 PSAT1 SPAC1F12.07 Pnpo FN1464 DXS 1275935 PF3D7_1337200 Psat1 pdxB ser-7 serC SER1 PYRIDOXAL PHOSPHATE SALVAGE PATHWAY%PANTHER PATHWAY%P02770 Pyridoxal phosphate salvage pathway pdxY PDXK Pdxk PPOX1 Tb927.6.2740 SPAC1093.02 SPAC6F6.11c PDX3 pykA pdxH pdxK pdxk-1 1276596 PNPO 1269333 SPCC18.10 Pnpo PK BUD17 RGD1566085 BUD16 PYRIMIDINE METABOLISM%PANTHER PATHWAY%P02771 Pyrimidine Metabolism DPYD mmsA pdp CG17896 SSO1218 CDA Os07g0188800 UGA1 DPYS Aldh6a1 ABAT iolA TM_1653 PYD2 ALDH6B2 NT5E Nt5e DPYSL5 MA_3242 DPYSL2 DPYSL3 Dpyd gatA gta-1 PYD3 deoA Dpysl2 Dpysl3 Upb1 SCO2726 Dpysl5 cdd-1 Dpys GATA MJ0667 dpysl3 Abat UPB1 upb-1 SCO4890 dht ALDH6A1 DR_0443 Os01g0807900 PYRUVATE METABOLISM%PANTHER PATHWAY%P02772 Pyruvate metabolism Pc GL50803_0014285 ME1 FN1379 citE AGT3 citA PDA1 TVAG_371320 TVAG_171090 At3g25960 DR_2206 ACLY ANIA_04462 PYC1 PKM Pkm Pepck SCP1.302 Clybl PYC2 gltA LDH1 Pklr pyk2 bauA pyk-2 PDH-E1 pykA comC PF3D7_1324900 MBK5.16 pda1 Acly Pdha1 Pdha2 SCO1270 SCO4388 cit-1 F1I16_60 TVAG_239990 PA0883 pckG PCK1 Pck1 CIT1 Csl CBG11570 C01G10.7 lhpD PDHA2 PDHA1 pyK Rv3075c PKLR Rv0843 TVAG_455680 F1I16_220 CS PC SCO2033 Me1 PAE2644 pdhA PA1400 SCO6471 pyc-1 pyr1 MAH20.13 yjmC TVAG_534540 pyk MAE1 DR_1240 CLYBL Cs MDH Os02g0739600 PAE3584 RAS PATHWAY%PANTHER PATHWAY%P04393 Ras Pathway Atf2 Tiam1 ATF2 Sec5 ARAF grb2 Elk1 mapkapk2a ELK1 akt3b RPS6KA3 RPS6KA6 RPS6KA2 Akt3 RPS6KA1 AKT3 Akt1 AKT1 gsk3ba BRAFLDRAFT_126918 gsk3bb p38b Rala Ralb Araf rho-1 GBGT1 TIAM1 bsk BRAFLDRAFT_122664 mapk14a Pi3K92E mapk14b braf RALGDS Jun JUN grb2a grb2b BRAF RPS6KA zgc:55558 GRB2 Grb2 Rgl1 RGL1 RGL2 Rgl2 ralaa ralab Rhoc exoc2 Pik3c3 Rhoa Rhob cdc-42 Rac2 RAC2 RAC3 Rac3 RAC1 Rac1 racB HRAS MAPk-Ak2 rasA rac1 SIRT6 rhoad RHOC rhoac rhoab RHOA rhoaa RHOB 1269341 rhob EXOC2 pikB nras pikC hrasb hrasa DAPPUDRAFT_301818 Map2k7 Map2k6 NRAS Pak1 PAK1 cdc42l stat3 cib2 PLDALPHA1 pikA Pak3 PAK3 Pak2 PAK2 MAP3K1 RAC6 STAT1 STAT3 RAC5 pak2 Map2k4 Map2k3 cRhoA Map2k2 Map2k1 cRhoB Stat3 LOC685590 Stat1 Hras Mapk9 cRac1A Mapk8 Os06g0604300 Mapk1 MAP3K7CL Ets1 ETS1 Mapk3 Map3k4 rac1a PLDGAMMA1 rac1b gskA 1276139 PLDGAMMA3 MAP3K4 MAP2K3 MAP2K4 MAP2K1 ets1 MAP2K2 Exoc2 Map3k1 EHI_070730 Nras MAPKAPK3 DAPPUDRAFT_301996 CEK1 MAPKAPK2 sec-5 ARAC4 RAF1 Raf1 Shc1 SHC1 Pld1 PLD1 Pld2 PLD2 Pik3cg Pik3cb MAP2K7 Pik3cd MAP2K6 rhoca Pik3ca age-1 mapk10 ralba srfa Ralgds 8029221 Sos DAPPUDRAFT_306746 CiGSK v1g189251 mapk12 GSK3B GSK3A cdc42 DAPPUDRAFT_299952 PIK3CD PIK3CB map2k6 map2k4a PIK3CG TRIADDRAFT_50431 Pdpk1 Map3k7cl mapk8 PDPK1 mapk3 AgaP_AGAP012108 mapk1 Gsk3b Rps6ka3 Gsk3a PIK3CA ppk21 Rps6ka1 Rps6ka2 PIK3C3 SOS1 Sos2 let-60 Sos1 SOS2 RALA Os06g0604200 RALB ARAC2 SRF Srf CDC42 MAPK9 MAPK8 rac3a rac3b MAPK1 Kras MAPK3 Cdc42 Mapk12 Mapk13 Mapkapk3 Mapk14 Mapkapk2 pik3ca kras MAPK14 MAPK12 MAPK13 MAPK10 MAPK11 KRAS Mapk10 Mapk11 S-ADENOSYLMETHIONINE BIOSYNTHESIS%PANTHER PATHWAY%P02773 S-adenosylmethionine biosynthesis Mat2a sam1 Os01g0207300 MTR Mtr TM_0268 FN0163 wasll MAT2A METK4 METK3 sams-5 PF3D7_0922200 metK sams-4 sams-3 METK2 yitJ sams-1 metH MAT1A SCO1657 SAM1 SAM2 CBG19844 eth-1 1269245 Mat1a Sam-S DR_0966 metr-1 mat2ab SALVAGE PYRIMIDINE DEOXYRIBONUCLEOTIDES%PANTHER PATHWAY%P02774 Salvage pyrimidine deoxyribonucleotides TK1A CDA Cda guaD DEADC1 thk-1 SCO4974 TM_1653 tad2 TADA MA_3407 CELE_R13A5.10 TK1B yfhC LMJF_21_1210 CDD1 TM_0846 Dmel\CG8353 MA_3242 PAE0794 DR_2177 TK1 deoA 8032909 CELE_JC8.4 cda cdd cdd-1 Dmel\CG8349 tilS MJ0667 CBG09150 cdd-2 thyB ADAT2 SCO4889 Dmel\CG5292 SCO4890 DR_0443 pcd1 CELE_Y48A6B.7 tdk Tk1 tadA TAD2 Dmel\CG8360 pdp Adat2 SALVAGE PYRIMIDINE RIBONUCLEOTIDES%PANTHER PATHWAY%P02775 Salvage pyrimidine ribonucleotides UPP2 l(2)k01209 UPP1 Dmel\CG6330 CELE_JC8.4 TTM2 1274917 TTM1 Cmpk NME2 NME3 tilS NME4 CBG09150 Cmpk1 Ak8 Dmel\CG5292 upp urk1 CELE_Y48A6B.7 CMPK1 UPRT tadA TAD2 udk guaD F40F8.1 CELE_F19B6.1 CBG03314 DEADC1 SCO4974 Os02g0708200 tad2 uck2a Dmel\CG17224 FCY1 1272077 pyrK C29F7.3 UKL5 UKL4 C47B2.2 UKL3 UKL2 UKL1 Uckl1 8032909 SPAC1399.04c GIP1L codA SPAC1B3.01c ADAT2 UCKL1 1278788 UCK2 UCK1 CMPK Uck Uck1 Uck2 Adat2 Dmel\CG3788 URK1 TADA MA_3407 CELE_R13A5.10 yfhC UPP Upp1 Upp2 SCW_SIGNALING_PATHWAY%PANTHER PATHWAY%P06216 SCW_signaling_pathway scw tsg sog Smurf sax Med tld put alph Fur1 Mad nej Pdp SERINE GLYCINE BIOSYNTHESIS%PANTHER PATHWAY%P02776 Serine glycine biosynthesis PA4960 SCO1808 serA-1 GH26 Psat1 serA-2 LOC_Os03g06200 Phgdh TM_0327 PGDH3 SER33 MJ1594 PAE3320 serA SER2 serB2 SER3 serC SPBC3H7.07c serB SER1 aay PHGDH SPCC364.07 CBG20736 PSPH PGDH1 PGDH2 C31C9.2 F26H9.5 CG11899 TM_1401 AgaP_AGAP012247 DR_1291 PSP slr2123 CBG22021 SCO5515 PSAT2 serA1 PSAT1 serA3 SPAC1F12.07 CELE_Y62E10A.13 Psph 1275935 1279816 SUCCINATE TO PROPRIONATE CONVERSION%PANTHER PATHWAY%P02777 Succinate to proprionate conversion SCO6832 mmdA TK1149 TK1622 DR_1189 Pccb scpB MMUT SCO6284 SCO4926 DDB0166993 yngE SCO5535 SCO4869 SCO5415 8032893 TM_0716 SCO6472 accD4 accD6 pccb-1 PCCB accD5 ECHDC1 Mmut DR_1316 mmcm-1 mutB mutA mcmA2 DR_2032 mcmA1 yqjD Echdc1 DR_1084 ppcB SULFATE ASSIMILATION%PANTHER PATHWAY%P02778 Sulfate assimilation cysJ redA MET10 SYNAPTIC_VESICLE_TRAFFICKING%PANTHER PATHWAY%P05734 Synaptic_vesicle_trafficking SNAP25 RAB3C RAB3A Syt11 Syt12 RIMS2 Stxbp1 RIMS1 Nsf2 rab3a Syt15 NSF UNC13B Nsf UNC13C Rims2 SEC18 Vamp1 UNC13D Unc13c STX1B Unc13b VAMP1 comt STX1A VAMP2 Unc13d Sytl3 nsf stx1b STXBP1 stx1a snt-1 STX2 Stx2 Stx1b Syt5 SYT5 Syt3 SYT3 SYT2 Syt2 SYT1 Syt1 nsf-1 snt-4 SYT15 stx2 Syt8 SYT7 Syt7 Stx1a SYT6 Syt6 Rab3a Snap25 SYT12 SYT11 TCA CYCLE%PANTHER PATHWAY%P00051 TCA cycle gltA FH comC aco Cs Pdha1 Pdha2 ybhJ SCO1270 Suclg1 sucD Ogdh Os10g0478200 CIT2 odhA sdhB Pdk2 PDK2 TVAG_165340 mAcon1 kdgA PDHA2 Fh PDHA1 MDH1 MDH2 mAcon2 cshA sdh3 SDHC GSU2445 cts-1 mdh cs CS FUM1 fumC OGDH acoA pdhA ACO1 SUCLG1 DICPUDRAFT_50173 Aco2 ACO2 ap33-1 anon-WO0140519.178 ap33-2 T CELL ACTIVATION%PANTHER PATHWAY%P00053 T cell activation Pik3ca grb2a BRAF BRAFLDRAFT_59748 Pik3c2g Nfkbia NFKBIA 11217 PTPRC PGTG_11337 BRAFLDRAFT_87235 CAM7 CD28 Grb2 CALM1 CAM2 Lat LAT Itpr1 Zap70 Ikbkb cdc42 CAM1-3 TRIADDRAFT_37105 PIK3CD CD3G Braf PIK3CB CD3E Pik3c3 CD3D PIK3CG IKBKB PPP3CA PPP3CB PPP3CC NCK2 Nck2 Rac2 Cd28 Rac1 RAC1 HRAS NCK1 Nck1 VAV3 Vav3 PHYPA_013668 UMAG_03910 CHUK rac1 SIRT6 FOS Fos Vav1 CAM VAV1 Cam VAV2 mapk1 Vav2 ZAP70 PIK3CA LCK Lck LCP2 PIK3C3 SOS1 Sos2 Pik3r1 Sos1 SOS2 Pik3r2 Lcp2 Pik3r3 AgaP_AGAP010957 v1g88970 hrasb Cd247 Cd3g hrasa Cd3e Cd3d CDC42 MAPK9 NRAS Pak1 PAK1 MAPK8 rac3a MAPK1 Csk CSK Pak3 PAK3 PHYPA_018206 Pak2 PAK2 MAPK3 Cdc42 MAP3K1 pik3ca pak2 MAPK10 Map2k2 Map2k1 cmd-1 LOC685590 Chuk CD247 Hras Mapk9 CD86 cRac1A CD80 BRAFLDRAFT_124869 ARAF Mapk1 Mapk3 rac1a akt3b rac1b AKT2 GRAP2 Akt3 AKT3 Akt2 Akt1 AKT1 BRAFLDRAFT_126918 calA Cd86 MAP2K1 MAP2K2 Cd80 Plcg1 Araf v1g239788 Prkcq Map3k1 Nras PRKCQ RAF1 Raf1 CALM ITPR1 Calm3 PIK3R3 PIK3R2 PIK3R1 Calm1 LMJF_09_0910 calm3b Pik3cg PLCG1 Pik3cb Pik3cd Ptprc Ppp3ca Ppp3cc Jun JUN Ppp3cb TETRAHYDROFOLATE BIOSYNTHESIS%PANTHER PATHWAY%P02742 Tetrahydrofolate biosynthesis LmjF06.0860 CDC21 At2g21550 F25B5.6 SCO3398 gch2 FPGS FN1014 MitHPPK/DHPS Ts Tyms Tb927.7.5480 Pu CytHPPK/DHPS met-6 dfr1 SPAC15E1.04 1272582 PF3D7_0417200 DR_0340 SPAC17A5.13 folKP TMP1 dfrA DFR1 folE2 FPGS3 TM_0040 FPGS2 thyA2 glr1487 TM_0166 thyA1 dhpS sul TYMS FOL2 FOL1 folC Dhfr 1279701 1277049 FOL3 folE NCU01337 DR_2632 LOC_Os10g35940 BT_2149 cat-4 folP tyms folE1 MET7 fol3 GCH1 Gch1 met7 thyA gch-1 FOLB3 FOLB2 FOLB1 folA folB DHFR FN0073 DHFS DR_0168 SCO5141 DR_0169 Fpgs BT_3646 dhfr-1 dhfr tyms-1 DHFR2 gchA THY-1 PF3D7_1224000 SCO2614 PF3D7_1324800 TGF-BETA SIGNALING PATHWAY%PANTHER PATHWAY%P00052 TGF-beta signaling pathway TGFB1 bmp2 mav SMAD3 SMURF2 gdnf TGFB3 SMURF1 mapk10 dpp spaw fkb-8 v1g247341 SMAD9 INHBB INHBA SMAD6 INHBC BMP7 Bmp7 fkb-2 SMAD5 LOC699676 BMP6 Bmp6 FUS3 SMAD7 BMP5 Bmp5 INHBE BMP4 Smad1 Bmp4 BMP3 Bmp3 Smad2 Smad3 BMP2 Bmp2 Smad4 nas-39 BMP1 Bmp1 GDNF BAMBI Smad9 glr0841 fkpA Bambi Inhba Tab1 TAB1 Inhbb mapk12 Smad5 BMPR1B Inhbc fkr-2 Smad6 Smad7 Inhbe BMPR1A BMP10 jnk-1 BMPR2 KSS1 CrMPK2 CELE_Y51B9A.9 tll1 BMP15 Bmp10 Cers1 Dmel\CG17168 Map3k7cl daw derriere cited4b Bmp15 1270913 mapk8 mapk3 sma-4 sma-2 Med TGFBR1 TGFBR2 mapk1 Foxh1 sma-6 DR_1839 Skil let-60 Smox Acvr1c ACVR1B acvr1ba DDL MAPK9 MAPK8 ACVR1C MAPK1 Acvr1b MAPK3 FKBP12.6 Mapk12 Mapk13 Mapk14 wit bmpr1ab bmpr1aa sax kras MAPK14 ACVR2B MAPK12 ACVR2A 1280735 MAPK13 MAPK10 1277335 Bmpr2 MAPK11 mstnb mstna bmp7.2 Acvr2a Jra Tll2 TLL2 TLL1 Tll1 KRAS SNOG_03299 Acvr2b Tgfbr1 Tgfbr2 Mapk10 Mapk11 gdf9 Atf2 ATF2 Fkbp1b UMAG_03305 ZFYVE9 ndr2 Fkbp1a ndr1 MPK4 MPK5 acvr1l foxh1 MPK6 MPK7 MPK1 MPK2 MPK3 gdf6b junbb cVg1 DSL1 rab-10 JUNB p38c HAC12 p38b p38a ACVR1 LOC526524 scw FOXH1 mpkB Dcp1a Lefty2 ZFYVE16 alg5 bsk dvr1 Jund myo rheb-1 mapk14a FPR1 Lefty1 RRAS Tak1 inhbaa Cited1 Cited2 mapk14b fkh1 CREBBP JUN Jun JUND GDF2 Gdf2 GDF1 Bmpr1a Gdf1 Bmpr1b Smurf Gdf3 GDF3 GDF6 Gdf6 GDF5 Gdf5 pmk-2 pmk-1 GDF7 Gdf7 FOSL1 Crebbp GDF9 Gdf9 Nodal tgfbr2b 1273058 spk1 rras2 Junb DCP1A GDF-9 dbl-1 Ehras1 NODAL acvr2b DCP1B ACVRL1 MSTN CITED1 CITED2 CITED3 RAS2 RAS1 Fkbp2 rasD ChALK5 rasG Actbeta cdc-42 inhbb rasS Bmp8b Bmp8a HRAS LEFTY1 unc-129 SCO1638 rasA RRAS2 rasC rasB tag-68 Cbr-tag-68 Acvr1 Rras fkbp1aa fkbp1ab ras1 Smurf2 1269341 Smurf1 ras-1 kgb-1 DCP1 nras hrasb Ep300 C49C3.10 hrasa DAPPUDRAFT_301818 Fkbp12 NRAS gdf11 Acvrl1 bmp7a LEFTY2 tkv GDF10 GDF11 babo Mstn GDF15 gbb BMP8A bambia BMP8B bambib tld FKBP1A SKI Ski cbp-1 FKBP1C cbp-3 FKBP1B mpk-1 Gdf15 Hras Gdf11 Gdf10 AgaP_AGAP009207 Mapk9 Mapk8 AMHR2 lft1 MAP3K7CL Mapk1 lft2 Map3k7 put Mapk3 1280504 BRAFLDRAFT_129112 mak-2 acvrl1 SNIP1 EP300 Ras85D MAP3K7 smad3a tig-2 smad3b HAC1 HAC2 BRK-3 HAC5 admp HAC4 bmp2a bmp2b tgfb2 Mad tgfb1a Nras SS1G_13801 smurf1 SS1G_11866 smurf2 CEK1 tgfb3 Sara FKBP2 daf-1 skib fkbp1b MPK10 skia MPK13 MPK14 MPK11 tok Tgfb1 smad2 Tgfb2 smad1 Gdnf 1272354 Tgfb3 daf-8 Amhr2 daf-7 SKIL daf-4 smad5 SMAD2 SMAD1 Fosl1 bmp4 SMAD4 TGFB2 bmp1 THIAMIN BIOSYNTHESIS%PANTHER PATHWAY%P02779 Thiamin biosynthesis FN1464 dxs2 dxs1 dxs DXS thiE1 thiE PF3D7_1337200 DXPS3 THIAMINE METABOLISM%PANTHER PATHWAY%P02780 Thiamine metabolism THTPA Thtpa TPK1 PAE2365 THI80 tnr3 THREONINE BIOSYNTHESIS%PANTHER PATHWAY%P02781 Threonine biosynthesis THR1 thrA DR_1278 thr-4 dapG hom AK1 AK2 BT_1375 lysC SCO5354 At1g01630 SCO5355 yclM MA_2572 AKHSDH1 PAE2878 Os09g0294000 gll1774 thrC2 thrC1 CNB01150 HOM3 NCU04118 NCU03425 HOM6 BT_1901 asd glr1017 ask SCO4293 P0482D04.19 SPBC776.03 usg thrC-1 thrC-2 TM_0546 SPBC4C3.03 TM_0547 TS2 thrc TS1 TM_1518 DR_1365 MA_0131 BT_2403 DR_A0360 Thnsl1 Thnsl2 NCU03935 LMJF_14_0350 HSK SPBC19F5.04 SCO0420 TM_1523 At5g21060 THNSL1 At1g14820 SCO3615 THR4 thrB thrC THYROTROPIN-RELEASING HORMONE RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P04394 Thyrotropin-releasing hormone receptor signaling pathway norpA PRKCG gpb-2 PRKCI gpb-1 PRKCH PRKCB PRKCE PRKCD Plcg1 Pkcdelta PRKCA Pkc53E Prkcq Plcg2 TRHR Prkcg Prkch Gbeta13F gnb1b Prkci Prkcb Prkcd Prkce PRKCQ Prkca Gng10 Plch1 PRKCZ GNG10 gna11b BRAFLDRAFT_220697 PLCG2 sl PLCG1 CGA Cga Galphaq Prkcz SNAP-25 Gngt2 Plcz1 GNG12 Snap29 Snap24 Snap25 Snap23 AgaP_AGAP012252 cga Gng12 AgaP_AGAP002578 Plcb4 Plcb3 ccb-2 ccb-1 prkcq egl-8 plcg1 Plcb2 Plcb1 prkci git5 GNGT2 STE4 prkcb AgaP_AGAP009115 Syb Vamp8 Vamp1 unc-2 Vamp3 Vamp2 SS1G_03482 VAMP8 PLCB3 PLCB4 GB1 VAMP1 PLCB1 PLCB2 VAMP2 VAMP3 syb1 prkchb CND03830 vamp8 vamp2 Pkc98E Plcd1 Plcd4 Plcd3 1281667 1281784 snap25a snap25b Stx3 STX3 1270776 Cacnb3 Cacnb4 gnb-1 Cacnb1 Gbeta5 Cacnb2 NCU02175 Plce1 gpbA PLCD3 PLCD4 aex-4 PLCD1 Cacna1e Cacna1a gnb1 Cacna1b gnb2 prkcbb prkcba AgaP_AGAP002748 DICPUDRAFT_93216 plc1 pkc-1 CACNB1 CACNB2 pkc-2 CACNB3 pkc-3 CACNB4 egl-30 prkcda CACNA1B CACNA1A CACNA1E tshba plcd1b Gbeta76C 8035476 Gnaq 1281188 nSyb tpa-1 gnaq PLC4 PLC3 PLC5 cacnb4 PLC2 PLC1 PLC8 PLC7 GNB2 Gnb2 GNAQ GNB1 Gnb1 PLC9 GNB4 Gnb4 GNB3 Gnb3 GNB5 Gnb5 ANIA_08769 SNAP25 Gnaq1 gngt2a snap-29 SNAP23 aPKC Trh TRH stx3b plc-2 plc-3 1276578 plc-4 1276579 PLCZ1 plc-1 SNAP29 TSHB Os07g0694000 sfaD SNAP33 1276580 SNAP30 trhr3 gnb5b gnb5a Gna11 snb-1 ric-4 cac trhr-1 Gna14 pll-1 SNC2 GNA14 GNG3 Gng3 GNG2 Gng2 GNG5 Plcl2 Gng5 Plcl1 GNG4 Gng4 GNG7 GNA11 inaC Gng7 Gng8 GNG8 Trhr2 gng2 gng3 gng5 PLCL1 plc PLCL2 gng7 Mlnr gnb3b gnb3a Tshb Trhr PLCE1 Plc21C TOLL_PATHWAY_DROSOPHILA%PANTHER PATHWAY%P06217 Toll_pathway_drosophila slmb spz ea Myd88 pll cact Spn27A Tl dl SPE TOLL RECEPTOR SIGNALING PATHWAY%PANTHER PATHWAY%P00054 Toll receptor signaling pathway myd88 Map3k8 Elk1 Map3k7 ELK1 Mapk3 Ube2n TBK1 Tbk1 Ticam2 MAP3K8 MAP3K7 MAP2K3 MAP2K1 TICAM2 MAP2K2 tol-1 TICAM1 Tank 18w Map3k1 CEK1 UBE2V1 bsk mapk14a LY96 Ube2v1 IRAK1 Tak1 mapk14b Irak4 CD14 Jun JUN Tollip Irak1 Myd88 Nfkbia NFKBIA TOLLIP UBE2N Cd14 Tab1 TAB1 NFKBIE Toll MYD88 Ikbkb TNFAIP3 ECSIT map2k4a IKBKB TLR2-1 TLR2-2 TMEM189 Tl IKBKE TOLL6 CHUK mapk8 mapk3 uev-1 IRAK3 SIRT6 IRAK4 Uev1A Ly96 TIRAP mapk1 Tlr1 IRF3 Irf3 TRAF6 TLR9 Tlr9 TLR8 TLR10 TLR7 Tlr7 TLR6 Tlr6 Tlr4 Tirap TLR4 TLR3 TLR2 Tlr2 TANK MAPK9 MAPK8 ube2nb UBE2NL ube2na MAPK3 Toll-7 Toll-6 Mapk14 MAP3K1 MAPK14 MAPK10 Map2k3 Map2k2 Map2k1 Chuk Tnfaip3 v1g137658 Mapk9 TRANSCRIPTION REGULATION BY BZIP TRANSCRIPTION FACTOR%PANTHER PATHWAY%P00055 Transcription regulation by bZIP transcription factor polr2ea tfbB TFA2 TFA1 tfbC tfbA BRP4 1279496 tfb gtf2e1 gtf2e2 tfb2 PRKAR1B PRKAR1A TBPL2 tfb1 TBPL1 8037586 Atf6 mia At5g15570 EOG090X0PCK NRPB3 Bug22 sa NRPB4 Taf9b creb3l3l Rpb10 PRKAR2B PRKAR2A GTF2A1L kin-2 AgaP_AGAP005731 CREBBP MTERF2 tcf-29 TfIIEalpha Crebbp 1278625 At3g09360 tbp-1 NCU01322 At3g16680 DAPPUDRAFT_304965 v1g190658 LMJF_15_1200 Taf7l tbp2 tbp3 At1g03280 STON1 tbpA TfIIA-L gtf2h3 crh-2 TDS4 tbp1 Tb11.02.2210 TFG2 NCU01515 RpII18 Tbpl2 NRPD5B gtf2b Tbpl1 tfg2 1280317 NCU05305 TAF6B CNA05510 Prkar1a Prkar1b Ep300 RPB3 Rpb3 PSMC3IP Rpb8 RPB6 RPB5 Rpb5 TAF9B rpb8 NCU08030 BRF2 Brf2 BRF1 rpb5 Brf1 rpb4 Prkar2a NRPE5C Prkar2b BCY1 NRPE5A BATDEDRAFT_32931 GTF2H1 GTF2H3 GTF2H4 1276084 atf-6 Mterf1a Mterf1b brf1 rpb-8 rpb-5 TBP2 v1g171933 rpb3 BRAFLDRAFT_118777 NCU02615 TRIADDRAFT_18503 GTF2B Ttf2 TTF2 TTF1 Ttf1 1274077 fcp1 8034249 EP300 1271006 Gtf2f2 Gtf2f1 1274516 NCU04770 TfIIFbeta cfap20 HAC4 GTF2F1 gtf-2e1 GTF2F2 gtf-2e2 1280879 Pka-R1 Pka-R2 AgaP_AGAP010493 Gtf2b WBGene00110656 Gtf2e1 Gtf2e2 prkar1b Taf1c CREM Creb3l3 PKAR Creb3l4 gtf-2A2 Creb3l1 Creb3l2 SPT15 GTF2E1 GTF2E2 Crem Gtf2h1 Gtf2h4 Gtf2h3 DAPPUDRAFT_308488 MNC17.14 1276961 pkaR BRAFLDRAFT_283143 NRPB5L1 tlf-1 taf7 taf8 Trf taf6 taf-7.2 mcb taf2 TFIIB2 TFIIB1 polr2l taf-8 Taf11 polr2f PF3D7_1223100 polr2h Taf12 toa2 polr2c TfIIEbeta NRPB9A NRPB9B toa1 TfIIB brf-1 Creb1 Creb3 Tbp TBP At1g07470 NCU01580 Creb5 cgs1 Cfap20 Gtf2a1 TFIIB CrebA CREB3 Gtf2a2 CrebB CREB1 TfIIA-S-2 TFIIAy NCU09748 TfIIFalpha e(y)1 gtf2a2 CREB5 GTF2A1 GTF2A2 tbp EHI_112050 TAF9 Taf9 Polr2h 1279068 Polr2e Polr2f Polr2l B0336.13 At2g45100 tfa1 tfa2 TAF1C POLR2C POLR2E POLR2F POLR2H CFAP20 AgaP_AGAP004940 POLR2L SUA7 TAF12 TAF11 PF3D7_0205500 TOA2 TOA1 sua7 1273770 1271351 Taf8 TAF8 Os01g0510800 creb1b Taf7 TAF7 let-607 TAF6 Taf6 TAF4 Taf4 TAF2 Taf2 Gtf2a1l TFB4 polr2l.1 PBRP2 TFB2 CREB3L3 F14P3.19 prkar1ab At4g20810 CREB3L4 CREB3L1 CREB3L2 tbpl1 tbpl2 prkar1aa LOC100912534 tfbF polr2eb NRPB5A tfbD TRIACYLGLYCEROL METABOLISM%PANTHER PATHWAY%P02782 Triacylglycerol metabolism Hsl LIPE LIPC Lipc Lipe hosl-1 TRYPTOPHAN BIOSYNTHESIS%PANTHER PATHWAY%P02783 Tryptophan biosynthesis trp-3 trp-4 TRP5 TRP4 aq_209 TRP3 F4F7.41 trp-1 At1g70570 PAE0257 trpF trpG trpD pabA trpE pabB trpB trpC MIF21.11 BT_0531 trp4 trp2 trp3 TRP1 trpB1 trpB2 ASB2 ASB1 trpD1 MAA7 trp1 DR_1766 ANIA_06231 trpGD trpC1 trpC2 FN1731 PAI1 PAI3 PAI2 trpE1 trpE2 PAT1 SCO3213 SCO3851 PAE2460 TSBtype2 trpD2 glr1559 TYROSINE BIOSYNTHESIS%PANTHER PATHWAY%P02784 Tyrosine biosynthesis glr2705 tyrA CM1 ARO7 aroH TM_0344 CM3 CM2 SCO1761 SCO1762 aro7 NCU07725 SCO3221 DR_1122 UBIQUITIN PROTEASOME PATHWAY%PANTHER PATHWAY%P00060 Ubiquitin proteasome pathway ANIA_02904 Nedd4 Os06g0600100 UBE2L6 RPT2A 8052988 UBE2L5 UBE2L3 RPT2B Os05g0182500 PHYPA_022320 At3g15120 PSMD7 PSMD4 PSMD2 PSMD1 psmc4 ube2l3a ANIA_02917 LMJF_13_1580 rfl-1 RPT1A PHYPA_002058 Os01g0273100 SNOG_02749 Ube2l6 SNOG_06548 Ube2l3 DAPPUDRAFT_304982 RPN7 Rpn2 RPN3 RPN1 rhp6 RPT4A RPT4B PHYPA_021379 UBC5A Rpn9 Os01g0819400 UBC5B RPN9B RPN9A L7845.06 PF3D7_0312300 LMJF_04_0680 DICPUDRAFT_92867 Atg7 ATG7 ube2al rpt-1 Uba1y TREX2 rpn12 mug30 DAPPUDRAFT_120690 v1g236730 Tb927.5.1000 OsRPT4 PHYPA_001782 OsRPT6 RPN8A NCU03623 rpn7 rpn6 rpn10 rpn1 rpn3 rpn2 PHYPA_013084 rpn8 ubc15 ubc16 uba-1 ubc13 PHYPA_029561 ubc14 ubc11 RPN2B PHYPA_026847 P0482D04.9 ube2v2 SNOG_16544 PHYPA_024544 TMEM189 ube2e3 NCU02289 SAE1A Ube2g2 Ube2g1 pan DAPPUDRAFT_308117 Os01g0673600 RPN1B RPN1A uvsJ 1281769 OsRPT2b ube2d4 ube2d2 ube2d3 Os06g0173100 PHYPA_018430 RPN2A UEV1C UEV1D spm2 PHYPA_016377 Smurf2 Smurf1 1272945 SAE1B-2 SS1G_02922 L6586.08 Psmc4 rpt3 PHYPA_028258 ubc-20 8034218 At2g32790 UBC29 Itch RPN5B UBC27 UBC20 ube2g1 ube2g2 pub1 pub2 pub3 Psmd2 ube2g1a Psmd4 Wwp1 TBP1 WWP1 WWP2 UBE2G1 Psmd1 Wwp2 UBE2G2 Ube2d2b ITCH Aos1 UBC36 PSMC4 PHYPA_020092 TBP2 psmC4 NCU03947 NCU03704 psmd7 LMJF_19_1120 Ube2s UBE3C UBE2D4 UBE2D2 UBE2D3 uba2 UBE2D1 uba3 UBE3A Ube2k uba1 UBE3B Ube2n Ube2c BRAFLDRAFT_285353 Ube2b HUL5 HUL4 PHYPA_010987 Ube2a SS1G_11173 ECR1 nas2 Os06g0607800 UBE2E3 UBE2E1 UBE2E2 Ubc84D ptr3 UBC18 Os02g0634800 Ube3c UBC13 ANIA_02761 UBC14 smurf1 Ube2d3 UBC15 ptr1 Ube2d2 smurf2 Rpt4 UBE2V2 Ube2d1 SS1G_01827 UBC10 UBC11 RPT3 Os02g0600100 Ube3b RPT1 Ube3a ubc-7 Os02g0325100 LOC_Os03g11570 PSMD14 UBA7 UBA6 PSMD13 pex4 RPN10 rad31 Os01g0511300 ubc4 Ube2v2 ubc1 Os05g0371200 PHYPA_005978 Ube2e3 Ube2e2 RPN12 RPN11 Ube2e1 UBE2B SMURF2 UBE2C SMURF1 PHYPA_018938 v1g239961 UBE2A BATDEDRAFT_14888 1272120 TIF3F1 UBE2S Uba1 UBE2T ube2b Uba2 Uba3 ube2c MDM2 UBE2N UBA3 UBA2 ube2a UBA1 SAE1 Sae1 UBE2K SAE2 pebp1.2 UBC8 PHYPA_006163 UBC7 UBC6 RPT6A Ubc6 LOC714349 RPT6B eif3f Psmd14 Psmd13 OsRPN11 OsRPN12 ube2d1b Os07g0166800 ube2d1a RPT5B RPT5A Os01g0839700 OsRad6 NCU01225 MNC6.8 NCU03526 ubc8 PEX4 Ubc4 ubc7 UBC5 BRAFLDRAFT_283521 UBC4 ube2l3 UBC2 Os06g0699900 PHYPA_018833 UBC1 PF3D7_0319300 AXL1 AGOS_AER173C ube2nb UBE2NL ube2na let-70 PBE1 psmd14 rpn-8 aos-1 rpn-6 eff UBCX PHYPA_023648 PF3D7_0305700 SS1G_11803 Os09g0297100 1271594 BRAFLDRAFT_128294 DAPPUDRAFT_299959 Os05g0460200 v1g137658 Tb927.6.1090 VALINE BIOSYNTHESIS%PANTHER PATHWAY%P02785 Valine biosynthesis Bcat2 SCO1176 PAE3300 PA4180 ilvD1 ilvD2 ILV5 ILV3 NCU04292 Ilvbl SCO5512 SCO2769 ILVBL MA_3792 Os05g0558400 NCU04579 1272265 ALS1 DHAD ilvC2 ilvC1 DR_1516 BCAT1 BCAT3 PA2035 BCAT2 ilvD ilvC BCAT4 BAT1 BCAT7 ilvE BAT2 BCAT6 ilvG ilvI aruI ilvK ilv5 ilvB1 ilvB2 DR_1626 ILV2 ilvB ilv-2 Dmel\CG1673 SPAC17G8.06c NCU05683 MA_1958 BT_2074 CBG03380 MJ0663 ilv1 MA_1354 CELE_Y44A6D.5 ilvE2 yagF ilvB-3 ilvB-2 ilvB-5 bcat-1 ilvB-4 At3g58610 ilvB-1 alsS yjhG T26C12.1 ALS SCO1888 Bcat1 ilvB-6 TM_0548 VASOPRESSIN SYNTHESIS%PANTHER PATHWAY%P04395 Vasopressin synthesis PREP At2g39960 Os01g0108200 Oxt OXT At1g52600 1273745 cpe prep pghm-1 SEC11 ptrB Prepl NHLRC3 oxt sec11a ptrBa Sec11c ptrBb Sec11a At1g20380 sec11 PREPL Pal2 Pal1 NCU06677 At1g76140 PA1304 Avp AVP lincRNA.224 At5g66960 1280809 Spase25 SPC3 Rv0457c twr spcs3 RB12337 AgaP_AGAP009172 gll0681 Phm At5g27430 avp SEC11A pamn-1 SEC11C Spcs3 Spcs2 spcs-2 spcs-3 sec-11 Spase22-23 Prep glr3271 DR_2503 SPCS3 pgal-1 SPCS2 SPCS1 Arxes1 spc3 Dmel\CG5355 CPE Cpe Tb11.52.0003 Pam PAM glr0129 At3g15710 OPB At4g04200 gll0625 VEGF SIGNALING PATHWAY%PANTHER PATHWAY%P00056 VEGF signaling pathway PRKCQ PRKD2 PRKD1 Prkca ptk2ab Arhgap8 SH2D2A mapk14a PIK3R3 PIK3R2 Pi3K92E PIK3R1 HIF1A PRKCZ paxB Hif1a PLCG2 mapk14b sl PLCG1 Prkcz Pik3c2b AgaP_AGAP011036 Pik3c2a BRAF pxl-1 Pik3c2g Ptk2 PTK2 AgaP_AGAP012252 ARHGAP8 TGFB1I1 Pax ARHGAP1 Pla2g4a Braf Pik3c3 Cryab Cryaa prkci rasD rasG prkcb Rac2 RAC2 RAC3 Rac3 rasS Rac1 RAC1 HRAS SPHK2 MAPk-Ak2 SPHK1 rasC SIRT6 rasB 1269341 CRYAA Pik3r1 Pik3r2 CRYAB Pik3r3 pikB nras pikC pikE hrasb hrasa DAPPUDRAFT_301818 NRAS AgaP_AGAP011890 Vegfa pikA kin-32 VEGFA Map2k2 Tgfb1i1 Map2k1 LOC685590 Hras AgaP_AGAP009207 1269955 rga-1 Mapk1 Ets1 Mapk6 ETS1 Mapk3 mak-2 AgaP_AGAP002748 dkf-2 Ras85D MAP2K1 Sh2d2a ets1 MAP2K2 pkc-1 pkc-3 Nras pla2g4a MAPKAPK3 Sphk2 MAPKAPK2 Sphk1 RAF1 Raf1 SHC2 PXN Pxn Hspb1 cryaba Pik3cg LPXN Hspb2 Pik3cb CG17401 Pik3cd tpa-1 kdrl Pik3ca age-1 v1g247341 vegfaa lin-45 RhoGAP68F PRR5 limB Prr5 FLT4 HSPB2 PIK3CD HSPB1 PIK3CB PIK3C2A PIK3CG PIK3C2B CASP9 plc-3 PLA2G4B PKD mapk3 PLA2G4A mapk1 PIK3CA PIK3C3 AgaP_AGAP000018 let-60 Lpxn Pi3K68D 1276231 1276232 inaC MAPK1 MAPK6 MAPK3 Mapkapk3 Mapk14 Pi3K21B Mapkapk2 piki-1 Casp9 Nos3 NOS3 pik3ca kras MAPK14 AgaP_AGAP010273 Raf KRAS Prkd3 ARAF Prkd1 Prkd2 LOC100177240 vps-34 KDR Akt1 Kdr AKT1 PRKCG cryaa PRKCI PRKCH PRKCB PRKCE PRKCD Plcg1 Araf PRKCA Pkc53E Prkcq Plcg2 Prkcg Prkch Prkci Prkcb PRKD3 Arhgap1 Prkcd Prkce VITAMIN B6 BIOSYNTHESIS%PANTHER PATHWAY%P02786 Vitamin B6 biosynthesis PF3D7_1337200 DXPS3 FN1464 dxs2 dxs1 dxs DXS VITAMIN B6 METABOLISM%PANTHER PATHWAY%P02787 Vitamin B6 metabolism RGD1566085 pdxY Pdxk PPOX1 CNB01150 Tb927.6.2740 SPAC1093.02 SPAC6F6.11c PDX3 pdxH NCU03425 THR4 thrC pdxK PSAT1 PK Pnpo PDXK Psat1 thrC-2 pykA thrc serC SER1 PNPO DR_A0360 SPCC18.10 thrC2 thrC1 VITAMIN D METABOLISM AND PATHWAY%PANTHER PATHWAY%P04396 Vitamin D metabolism and pathway raraa RARA 1271741 Rara F13B Gc GC Cpr VDR Vdr emb-8 rarab CYP27A1 ccr1 CYP27B1 CYP27C1 Rxra POR Cyp27a1 NCP1 Por RXRA Cyp27b1 WNT SIGNALING PATHWAY%PANTHER PATHWAY%P00057 Wnt signaling pathway Ep300 WNT8B Csnk1a1 FSTL1 FRZB HRR25 egl-20 gro WNT7B WNT7A BRAFLDRAFT_56711 Ankrd6 cbp-1 cbp-3 cka Chd1l GPRFZ2 GPRFZ4 MAP3K7CL Ctnnb1 Cdh9 Cdh8 Cdh7 Cdh6 Cdh5 Cdh4 Cdh3 Cdh2 Cdh1 1276254 MAP3K7 AgaP_AGAP009711 Tb10.70.6220 Tle4 Tle3 Tle2 Tle1 ctn-1 Ctnna3 Ctnna2 wnt4a Ctnna1 Fbxw11 Tle6 Tle5 RIM11 egl-30 PF3D7_0216000 BRAFLDRAFT_113587 smarcb1 sult1c4 ISW1 ISW2 CkIIbeta2 GPRSTN Gbeta76C smarcb1a smarca5 Dvl1 Dvl2 Dvl3 Ppp3ca Ppp3cc Ppp3cb CBL10 1278226 Bcl9 1276044 b4galt7 1279554 lin-44 UMAG_11308 AgaP_AGAP006475 cnaA ARRB1 ARRB2 Csnk1g3 Csnk1g1 Csnk1g2 cnb1 Map3k7cl axin2 axin1 wnt11 Csnk2b sfaD CNA1 Bap60 wnt7aa Pcdh1 chico At3g13670 ppp3r1b Csnk1d Csnk1e Ctnnal1 CNB1 Acvr1c 4576288 LRP5 LRP6 CKL10 Pcdh8 sll1366 Pcdh7 CKL13 CKL12 Pcdh9 Arrb2 Arrb1 Acvr1b AgaP_AGAP009731 PCDH1 AgaP_AGAP009734 AgaP_AGAP009716 PCDH9 cnbA bmpr1aa PCDH7 PCDH8 ppp2r5ea MA_0189 ppp2r5eb YCK2 CNJ02230 YCK3 Tgfbr1 SMARCAL1 SMARCB1 At4g08800 Dmel\CG2577 ARR3 ARR2 LOC395991 CSNK1B DICPUDRAFT_99718 DDM1 Wnt10a CER1 Wnt10b SMARCC1 At3g01890 SMARCC2 ctnna1 CSNK1D DDB0219999 csnk2b CSNK1E 1279371 HDA6 Ci-Nemo-Like SFRP4 SFRP1 SFRP2 HDA7 ARRK HDA9 Smarce1 SFRP5 CSNK2B csnk1d ppb1 ctbp1 Btrc AgaP_AGAP007924 LOC108348201 Gng10 Pcdhb16 PCDH10 Pcdhb17 ctnnb1 nkd Pcdhb18 ctnnb2 Pcdhb19 PCDH15 Tbl1x SWI3 PCDH12 Nlk PCDH19 alpha-Cat PCDH18 1278050 Os07g0495100 gna11b HLTF Pcdhb12 Pcdhb13 Pcdhb14 Pcdhb15 SNOG_01980 arm Pcdhb10 canA Pcdhb11 arr snf21 Kremen2 PCDH20 Kremen1 SMARCA5 TRIADDRAFT_63380 SMARCA1 SMARCA2 fbxw11a LMJF_21_1630 SMARCA4 fbxw11b PHYPA_000697 AgaP_AGAP012252 snfc-5 Pcdhb20 Gng12 Gng13 Pcdhb21 CkIIalpha Pcdhb22 PPP3CA PPP3CB PPP3CC BRAFLDRAFT_118309 SYD Sfrp2 Sfrp1 ANIA_03806 Sfrp4 Sfrp5 kin-10 1281899 FN1386 CND03830 Ppp2r5d Ppp2r5c Ppp2r5b Nkd2 Nkd1 Ppp2r5a 1281667 kin-19 LMJF_04_1210 ppp2cb AgaP_AGAP003579 PCDHB15 PCDHB14 PCDHB13 PCDHB12 PCDHB11 PCDHB10 1279592 hhp1 hhp2 tbl1xr1 Ppp2r5e AGOS_AGR395W PCDHB16 gpbA mig-5 PCDH11Y gnb1 PCDH11X gnb2 RPD3 CELSR1 isw-1 CELSR2 CELSR3 tcf7l1 Wnt5a Wnt5b EP300 IRC5 FBXW11 pkc-1 pkc-3 Pcdhgc5 casK pcdh8 UMAG_02065 DAPPUDRAFT_306765 TCF7 wntD WNT6 8035476 swr1 nlk2 Wnt3a Cdh24 Cdh23 Cdh22 Cdh20 WNT1 WNT2 WNT3 WNT4 wnt3 SINAT5 wnt2 wnt1 SINAT3 gnaq AgaP_AGAP010462 SINAT2 wnt5 Wnt2b GNB2 GNAQ GNB1 GNB4 GNB3 GSK3B GSK3A par1 par2 dvl3a Cdhr1 DACT1 SWR1 Cdh18 Cdh17 Cdh15 Cdh13 CDHR1 Cdh12 CDHR2 sma-6 Sag Cdh11 Cdh10 HDA19 Wnt16 LOC485469 Lef1 Wnt11 Gna11 mom-2 Gna15 Gna14 mom-5 Dact1 ACVR1B CanA-14F dco GNG3 ACVR1C GNG2 pcdhb GNG5 GNG4 GNG7 inaC 1276914 1272798 GNG8 gng2 gng3 csnk-1 CT_555 C52B9.8 clr6 BRAFLDRAFT_123893 fzd2 Pcdh10 fzd4 fzd5 fzd7 Pcdh19 Pcdh18 Fzd10 Pcdh12 Pcdh15 Os08g0344100 PRKCG PRKCI PRKCH PRKCB PRKCE PRKCD PRKCA Pkc53E Prkcq Prkcg Prkch Prkci cwn-1 Prkcb cwn-2 Prkcd Prkce PRKCQ AgaP_AGAP001944 Prkca hdac1 hdac3 CTBP2 SRCAP CTBP1 Cad74A PRKCZ siah1 PPP3R1 PPP3R2 PCDHA1 ssr2 ssr3 PCDHA5 PCDHA4 v1g161273 PCDHA3 PCDHA2 Prkcz PCDHA9 PCDHA8 PCDHA7 PCDHA6 FZD1 WNT10B WNT10A FZD3 FZD2 Cad99C FZD5 FZD4 FZD7 FZD6 FZD9 NFATC3 FZD8 NFATC2 ssr1 NFATC1 INO80 NFATC4 Pcdh20 phd1 PCDHB2 PCDHB1 fmi-1 PCDHB6 Fat2 PCDHB5 Fat1 sinah PCDHB4 PCDHB3 Fat3 PCDHB9 PCDHB8 PCDHB7 Plcb4 Plcb3 pygo Csnk2a2 Csnk2a1 Plcb2 ds Plcb1 fzd9b 8041094 Hells CT_708 Ctbp1 Ctbp2 Wnt9a itpr1 Wnt9b HELLS csnk1da CK2B csnk1db CK2A dsh-2 SS1G_03482 PLCB3 PLCB4 shg CiDsh Os05g0150300 Wnt8b Wnt8a PLCB1 PLCB2 DAPPUDRAFT_301140 cdh1 cdh2 CK1 fzd7a Smarcal1 fzd7b ft fz AgaP_AGAP011770 Wnt7b SPBC2G5.02c Wnt7a cna-1 ASK8 babo ASK3 CSNK1A1 ASK4 ASK1 ASK2 fzd8b fzd8a PA0799 PF3D7_0925700 Map3k7 CDH9 CDH8 CDH7 CDH6 CDH5 csnk1a1 CDH4 CDH3 ANIA_04493 CDH2 CDH1 DICPUDRAFT_93216 Arid1a Pygo2 PCDHAC2 Pygo1 PCDHAC1 Ppp2cb TLE4 TLE3 CSNK1G3 Ppp2ca TLE2 TLE1 CHD1L TLE6 TLE5 cdh17 PYGO1 PYGO2 Mad Frzb CSNK1G2 dom ITPR1 ITPR2 ITPR3 smad1 siah-1 At5g37870 LMJF_35_1730 DVL1 DVL2 DVL3 Celsr3 Celsr1 Celsr2 v1g245041 BCL9 itr-1 CkIIbeta CadN Itpr3 Itpr2 Itpr1 Hdac3 Hdac2 Hdac1l 1276578 1276579 Dmel\CG9962 Smarcb1 Hdac1 Snr1 Hdac8 HOS2 1276580 cdh-4 cdh-5 cdh-3 ywqA dsh Smarca2 PF3D7_1104200 Smarca1 Smarca4 ckb-2 ckb-1 Smarca5 Iswi pcdh8.2 yqhH SMARCD1 SMARCD2 HDAC2 SMARCD3 HDAC3 HDAC1 Lrp6 HDAC8 Lrp5 wnt10a Smarcd1 Smarcd3 Smarcd2 CTNNAL1 fz3 fz2 SMARCE1 fz4 ctbp-1 Os01g0570500 dact1 Smarcc2 Smarcc1 csnk2a2a fzd10 Pcdhb2 Pcdhb1 Pcdhb8 Pcdhb7 BRAFLDRAFT_104698 Pcdhb9 Pcdhb4 Pcdhb3 Arr3 At3g03940 Pcdhb6 Arr2 Arr1 Pcdhb5 CBL9 CBL7 CBL6 CBL5 CBL4 1270431 CBL3 CBL2 CBL1 BTRC brm HAC12 Cer1 SKP1 norpA gpb-1 LOC108348771 SS1G_00214 Mut9 Pcdha4 gnb1b Gbeta13F arr-1 NLK LMJF_21_0680 GNG10 1281346 alpha-Catr BRAFLDRAFT_220697 ckb1 1281582 Galphaq kin-3 CKA4 CKA3 CKA2 8041862 SIAH2 SIAH1 GNG12 GNG13 Crebbp RSC8 Siah1 cka1 Siah2 stan AgaP_AGAP006511 CKB4 CKB3 tcf7l1a CKB2 CKB1 B1046G12.17-1 egl-8 CanB prkci prkcb LOC_Os03g10940 ANKRD6 hda-1 hda-2 swsn-1 hda-3 swsn-3 swsn-4 wnt8a wnt8b KREMEN1 tle3b Bap111 KREMEN2 tle3a ttbk-7 Hltf sina AgaP_AGAP006732 DICPUDRAFT_26270 wnt5b NKD1 NKD2 PPP2CA wg PPP2CB CTNNA1 TBL1Y ppp2cab ppp2caa CTNNA3 CTNNA2 TBL1X smarce1 ham-3 gnb-1 LOC_Os10g41520 CTNNB1 smarcd1 Tb09.211.4890 LOC_Os03g55490 hmp-1 1282012 mor gskA AgaP_AGAP002748 PHYPA_000704 helZ 1272459 At5g14170 WNT5B gsk3 HAC1 1282023 WNT5A HAC2 HAC5 PCDHA13 HAC4 STH1 PCDHA12 PCDHA11 PCDHA10 TBL1XR1 Os01g0772600 HOS15 Wnt6 Wnt5 CDH20 Gnaq CDH22 CDH23 EP400 1281188 CDH24 Wnt2 Wnt1 tpa-1 Wnt4 Wnt3 SS1G_12241 SMAD1 SMAD4 WNT3A SMAD5 ebi Smad1 Smad4 Dmel\CG7094 Gnb2 Gnb1 Gnb4 Os01g0367900 Gnb3 CkIalpha Smad5 BMPR1B cki3 cki1 BMPR1A cki2 PCDHGB7 AgaP_AGAP002310 WNT2B PCDHGB6 PCDHGB5 Pp2B-14D PCDHGB4 PCDHGB2 plc-2 Tbl1xr1 PPP2R5E BRAFLDRAFT_271417 Nfatc4 hmr-1 Nfatc3 Nfatc2 PCDHGA8 PCDHGA7 PCDHGA6 PCDHGA5 PCDHGA3 PCDHGA2 PCDHGA1 AXIN1 PPP2R5B PPP2R5A PPP2R5D PPP2R5C AXIN2 ARID1A WNT16 ARID1B TGFBR1 Gsk3b 1273990 CDH10 CDH11 CDH12 PCDHGB1 SAG CDH13 Siah1b Siah1a CDH15 CDH16 arrb1 CDH17 CDH18 CDH19 Ppp3r2 Ppp3r1 unc-37 LEF1 CKL8 CKL7 acvr1ba CKL6 CKL5 CKL4 CKL3 GNA14 CKL2 GNA15 Gng3 WNT11 CMP2 Gng2 zgc:86598 Gng5 Gng4 Gng7 GNA11 Gng8 spe-6 zgc:136929 pptr-2 pptr-1 LMJF_35_1010 TCF7L2 TCF7L1 Pcdh11x_predicted PCDHGC5 PCDHGC4 PCDHGC3 slr2046 DR_1259 krz lef1 LMJF_35_1000 CSNK1A1L sfrp1 Cad88C tax-6 FZD10 gsk3ba WBGene00115054 tbl1xr1a CanA1 gsk3bb Plc21C tbl1xr1b DAPPUDRAFT_223674 CSNK2A1 Cad89D CSNK2A3 CSNK2A2 PHYPA_003021 Axin1 Ggamma30A Axin2 kug CanB2 DAPPUDRAFT_305830 BRAFLDRAFT_118160 wnt7bb arrb2a Tak1 lit-1 Tcf7l1 CHR23 Tcf7l2 PIE1 Fzd1 CKIalpha SNF2 CREBBP Fzd3 Fzd2 Fzd5 Fzd4 Fzd7 Fzd6 Fzd9 Bmpr1a Fzd8 Bmpr1b Dchs1 frzb2 PCDHGA10 PCDHGA11 PCDHGA12 1278620 FAT1 FAT2 Ino80 FAT3 DCHS1 BRAFLDRAFT_113720 ChALK5 AgaP_AGAP009115 cnb-1 Os01g0234900 CHR17 lin-17 Os07g0114400 WNT9B WNT9A Itpr 1274448 CHR12 YALI0_D16863g CHR11 frzb WNT8C WNT8A XANTHINE AND GUANINE SALVAGE PATHWAY%PANTHER PATHWAY%P02788 Xanthine and guanine salvage pathway SCO4917 SPCC1672.03c PA4645 TM_1596 GDA Gda Pnp2 hprt1 pnp-1 LOC510369 SCO3405 TM_0206 BT_4386 TM_1737 PNP Pnp XRPT DhpD hprT Tb10.70.6540 FN0288 HGPT NCU09621 SPAC1805.16c HGPRT punA Hprt1 hpt Prtfdc1 pnp DR_1376 hprt-1 GUD1 PNP1 PA1521 HPRT1 PF3D7_1012400 PA0134 CG16760 PRTFDC1 Tb10.70.6650 guaD RESISTANCE OF ERBB2 KD MUTANTS TO TRASTUZUMAB%REACTOME DATABASE ID RELEASE 76%9665233 Resistance of ERBB2 KD mutants to trastuzumab HSP90AA1 CDC37 ERBB2 ERBIN REGULATION OF PLK1 ACTIVITY AT G2 M TRANSITION%REACTOME%R-HSA-2565942.1 Regulation of PLK1 Activity at G2 M Transition HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PPP1CB PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 OFD1 PPP1R12A CEP135 BORA FBXW11 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 SUMOYLATION OF INTRACELLULAR RECEPTORS%REACTOME%R-HSA-4090294.3 SUMOylation of intracellular receptors VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR3C2 PIAS1 NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 SUMO2 RARA PPARG PGR PPARA PIAS4 HDAC4 PIAS3 UBE2I THRB RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE DURING HIV INFECTION%REACTOME%R-HSA-167160.2 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 PHOSPHORYLATION OF THE APC C%REACTOME%R-HSA-176412.3 Phosphorylation of the APC C ANAPC15 ANAPC16 ANAPC7 UBE2C PLK1 UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDK1 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 CCNB1 REGULATION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 76%169911 Regulation of Apoptosis PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 OPA1 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 ARHGAP10 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 OMA1 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PAK2 PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TNFS BIND THEIR PHYSIOLOGICAL RECEPTORS%REACTOME DATABASE ID RELEASE 76%5669034 TNFs bind their physiological receptors TNFRSF9 TNFSF13 TNFRSF1B TNFRSF1A EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFSF11 TNFRSF17 TNFRSF8 TNFRSF14 TNFRSF4 TNFSF18 EDARADD TNFSF14 TNFSF15 CD70 TNFRSF18 DEFECTIVE RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 76%9693928 Defective RIPK1-mediated regulated necrosis FADD CASP8 TRADD RIPK1 TRAF2 CONJUGATION OF PHENYLACETATE WITH GLUTAMINE%REACTOME%R-HSA-177162.1 Conjugation of phenylacetate with glutamine ACSM1 ACSM2B CLASS A 1 (RHODOPSIN-LIKE RECEPTORS)%REACTOME DATABASE ID RELEASE 76%373076 Class A 1 (Rhodopsin-like receptors) HTR1F HTR1D HTR1A HTR1B OPN5 CXCL10 PYY CXCL11 CXCL12 RLN2 RLN3 NMUR2 NMUR1 CXCL6 CXCL9 CXCL8 MLNR HTR2B HTR2C OXT ECE1 ADRA1D CXCL1 HTR2A ECE2 TRH CXCL3 ADRA1B CXCL2 ADRA1A CXCL5 LTB4R HEBP1 GPER1 BDKRB2 PRLHR BDKRB1 INSL3 QRFPR INSL5 TSHB PTGIR NPY5R GNRHR2 AVPR2 OPRM1 SSTR1 SSTR2 ADRA2C SSTR3 ADRA2B SSTR4 ADRA2A SSTR5 CORT ADORA2A ADORA2B XCL2 XCL1 CX3CR1 NPY4R OPRL1 P2RY6 CCL7 CNR2 P2RY4 CNR1 CCL5 P2RY2 CCL4 P2RY1 CCL3 S1PR1 CCL2 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HTR5A HCRTR2 TSHR APLN HCRTR1 KISS1 POMC OPN1SW SST ACKR4 ACKR3 ACKR2 ACKR1 NPFFR2 APP OXTR NPFFR1 RXFP4 RRH HTR4 GRPR RXFP1 RXFP2 RXFP3 EDNRA HTR6 EDNRB HTR7 C3AR1 OXER1 PROK2 PROK1 PTGDR CMKLR1 UTS2R TAAR8 TAAR9 TAAR6 NPFF TAAR5 TAAR2 GPR37L1 PDYN TAAR1 TRHR UTS2B KEL AGTR1 AGTR2 PTGFR LHB LPAR1 FPR1 LPAR2 LPAR3 FPR3 LPAR4 FPR2 C3 NLN MC2R C5 GALR3 GALR2 GALR1 NPBWR1 PENK NPBWR2 PPY HCRT CGA CCR10 NTSR1 NTSR2 CCR1 GPR17 NMB XCR1 PPBP NMBR MC1R LPAR5 LPAR6 NMS GPR183 PNOC NMU GNRH2 GNRH1 GPR18 PTGDR2 QRFP CX3CL1 MLN BRS3 MC4R GPR132 CCKAR OPN1LW CCR9 FFAR4 GNRHR CCR8 FFAR3 CCR7 FFAR2 FFAR1 CCR6 CCR5 CCR4 CCR3 OXGR1 CCR2 GPR39 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B GPR35 FSHB TACR2 GPBAR1 GPR31 TACR3 AVPR1A TACR1 F2 MC3R GAL ADRB3 CCKBR OPN1MW FSHR AVP RGR PTGER4 NPSR1 OPRD1 CCL13 NPB CCL11 PLPPR1 PLPPR2 GRP PTGER1 PLPPR3 PTGER2 PLPPR4 PTAFR PTGER3 PLPPR5 CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R RHO CCL19 PRLH CCL17 GPHA2 CCL16 CCL25 P2RY12 P2RY13 P2RY10 CCL22 P2RY11 CCL21 CCL20 P2RY14 GPR55 GPR4 AGT GPR143 XK MT-RNR2 MC5R SAA1 F2RL1 CCL28 CCL27 F2RL2 PF4 F2RL3 GPHB5 CHRM2 CHRM3 CHRM1 GPR68 CHRM4 GPR65 NPY2R CHRM5 PMCH CXCL13 CXCL16 CYSLTR1 CYSLTR2 ADORA3 CCRL2 ADORA1 GHSR LHCGR F2R NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 CCL3L3 C5AR2 C5AR1 ADRB1 ADRB2 NTS MCHR1 MCHR2 KNG1 HCAR2 HCAR3 TAAR3P HRH1 HCAR1 HRH3 TBXA2R HRH2 PSAP HRH4 TAC3 DRD1 DRD2 TAC1 DRD3 DRD4 DRD5 OPN4 OPN3 HTR1E DEGRADATION OF THE EXTRACELLULAR MATRIX%REACTOME%R-HSA-1474228.4 Degradation of the extracellular matrix PRSS1 COL16A1 COL12A1 CAPN15 CAPN8 CAPN9 CAPN6 CAPNS1 CAPN7 CAPNS2 CDH1 CAPN5 BSG CAPN2 CAPN3 CAPN1 PRSS2 CAST PHYKPL CTRB2 CTRB1 COL23A1 ADAM10 HSPG2 BCAN ADAM17 ADAM15 OPTC ADAM9 ADAM8 COL17A1 COL13A1 HTRA1 KLK2 PSEN1 NID1 KLK7 ADAMTS16 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 LAMC1 CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 ADAMTS1 CTSL CASP3 CTSK TIMP2 CTSG TIMP1 ADAMTS8 TPSAB1 ADAMTS9 CTSD CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 LAMA5 COL15A1 TMPRSS6 LAMA3 FURIN PLG COL19A1 ACAN SPOCK3 SPP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 CAPN11 CAPN12 CAPN10 TLL2 TLL1 KLKB1 ANTIMICROBIAL PEPTIDES%REACTOME%R-HSA-6803157.2 Antimicrobial peptides DEFB125 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 SSA1 RNASE8 ELANE SSA2 RNASE7 DEFA1B PI3 CHGA DEFB104B DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFA3 DEFB135 DEFB134 DEFB133 env DEFB108B LYZ DEFB132 CTSG DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 BPIFB6 SEMG1 LCN2 PGLYRP4 PGLYRP3 DEFB105B PGLYRP2 LEAP2 DEFB1 CLU HTN1 DEFB109B HTN3 S100A7A BPIFA1 GNLY BPIFA2 EPPIN PGLYRP1 ATP7A PRSS3 CAMP DEFB106B DEFB119 DCD DEFB118 DEFB117 DEFB116 SLC11A1 DEFB115 DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 PRSS2 BPI PRTN3 DEFB130A CCR6 DEFB130B DEFB4B S100A9 S100A8 TLR2 CCR2 LTF S100A7 REG3A DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 ITLN1 LIPOPHAGY%REACTOME DATABASE ID RELEASE 76%9613354 Lipophagy HSPA8 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG2 PLIN2 PRKAB1 PRKAG3 RHOV GTPASE CYCLE%REACTOME%R-HSA-9013424.1 RHOV GTPase cycle GIT2 TPM4 DST USP9X TPM3 TXNL1 MYO9A VANGL1 DEPDC1B PEAK1 DLG5 RHOV ARHGEF7 EPHA2 PAK2 CCP110 ZNF512B CLTC WASL PIK3R1 IQGAP1 SH3RF1 ARHGAP12 CDC42 PAK1 NCK2 PAK6 WDR6 CEP97 SPTAN1 GIT1 SPTBN1 NCK1 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 76%9683610 Maturation of nucleoprotein GSK3B PARP4 PARP16 PARP9 PARP14 N PARP8 SUMO1 PARP10 UBE2I PARP6 REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU-RICH ELEMENTS%REACTOME%R-HSA-450531.4 Regulation of mRNA stability by proteins that bind AU-rich elements TNFSF13 HSPA8 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 YWHAB PSMD14 HSPB1 PSMD13 ELAVL1 ZFP36 PSMA7 XPO1 PSMB10 KHSRP PSMA8 AKT1 PSMB6 TNPO1 PSMB7 NUP214 PSMB4 DIS3 PSMB5 PRKCD PSMB2 UBB PRKCA PSMB3 YWHAZ PSMB1 XRN1 PSMF1 MAPKAPK2 UBC PABPC1 PSMB8 DCP2 PSMB9 SET RPS27A SEM1 ANP32A PSMC5 PARN PSMC6 ZFP36L1 PSMC3 EXOSC7 PSMC4 EXOSC6 PSMC1 EXOSC5 PSMC2 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 MAPK11 DCP1A EIF4G1 HSPA1A P53-DEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 76%69580 p53-Dependent G1 S DNA damage checkpoint CCNA1 CCNE2 CCNE1 TP53 COP1 PCBP4 CDKN2A CDK2 MDM2 ATM MDM4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 HEDGEHOG 'OFF' STATE%REACTOME DATABASE ID RELEASE 76%5610787 Hedgehog 'off' state BTRC PRKACA SKP1 OFD1 GSK3B UBA52 CUL1 UBB PRKAR2B UBC RPS27A IFT172 PRKACG PRKACB DYNC2H1 RPGRIP1L RBX1 IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 INTU KIF3A TTC21B PRKAR2A PTCH1 IFT122 FUZ ADCY10 GNAS MKS1 GLI1 GLI3 GLI2 IFT52 SUFU IFT57 IFT140 KIF7 WDR35 NUMB ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 ITCH PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHONDROITIN SULFATE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%2022870 Chondroitin sulfate biosynthesis CHST11 CHST12 CHST15 CSPG5 CSPG4 CHSY3 CHST13 CHST3 DCN BCAN CSGALNACT1 CHST7 CHPF CHPF2 NCAN CSGALNACT2 BGN VCAN CHSY1 INTERLEUKIN-33 SIGNALING%REACTOME%R-HSA-9014843.2 Interleukin-33 signaling IL1RL1 IL33 RHOBTB1 GTPASE CYCLE%REACTOME%R-HSA-9013422.2 RHOBTB1 GTPase cycle TXNL1 SPEN RNF20 CCT2 CPSF7 ROCK1 ROCK2 CUL3 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 MYO6 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 REGULATION OF RAS BY GAPS%REACTOME%R-HSA-5658442.1 Regulation of RAS by GAPs RBX1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 SPRED3 PSMB5 SPRED2 PSMB2 UBB SPRED1 PSMB3 SYNGAP1 PSMB1 HRAS PSMF1 RASA3 UBC RASA4 PSMB8 RASA1 PSMB9 RASA2 RPS27A SEM1 RASAL1 PSMC5 RASAL2 PSMC6 RASAL3 PSMC3 NRAS PSMC4 DAB2IP PSMC1 PSMC2 NF1 KBTBD7 ALTERNATIVE COMPLEMENT ACTIVATION%REACTOME%R-HSA-173736.2 Alternative complement activation C3 CFD GZMM CFB TGF-BETA RECEPTOR SIGNALING IN EMT (EPITHELIAL TO MESENCHYMAL TRANSITION)%REACTOME%R-HSA-2173791.1 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) UBB UBC RPS27A TGFB1 UBA52 SMURF1 ARHGEF18 CGN F11R PRKCZ TGFBR1 RHOA TGFBR2 FKBP1A PARD6A PARD3 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 76%8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells CREBBP CSF2 CBFB PRKCB RUNX1 LGALS3 HHAT G278V DOESN'T PALMITOYLATE HH-NP%REACTOME DATABASE ID RELEASE 76%5658034 HHAT G278V doesn't palmitoylate Hh-Np SHH HHAT DHH IHH DEFECTIVE F8 SECRETION%REACTOME DATABASE ID RELEASE 76%9672397 Defective F8 secretion F8 RESPONSE OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 76%9637690 Response of Mtb to phagocytosis GSK3A ENO1 DUSP16 CORO1A eis lpdC esxH esxG RNF213 esxA UBA52 Rv1410c PGK1 ATP6V1H MAPK1 TRIM27 sapM Rv3655c ndkA MAPK3 CTSG KPNA1 Rv3364c ptpA secA2 UBB NOS2 VPS33B PPE2 lprG UBC lprM SFPQ HGS RPS27A RAB5A KPNB1 Rv3654c RAB7A VITAMINS%REACTOME%R-HSA-211916.1 Vitamins CYP26C1 CYP2R1 CYP26A1 CYP27B1 CYP26B1 CYP24A1 BIOSYNTHESIS OF MARESIN-LIKE SPMS%REACTOME DATABASE ID RELEASE 76%9027307 Biosynthesis of maresin-like SPMs CYP2C9 CYP2C8 CYP2D6 CYP1A2 CYP2E1 CYP3A4 NONSENSE MEDIATED DECAY (NMD) INDEPENDENT OF THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 76%975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 UPF1 RPS9 RPS7 RPL21 NCBP1 RPS8 NCBP2 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 GSPT1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 SERINE BIOSYNTHESIS%REACTOME%R-HSA-977347.4 Serine biosynthesis SRR PSAT1 PHGDH SERINC1 SERINC3 SERINC2 SERINC5 PSPH SERINC4 POSITIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 76%5250913 Positive epigenetic regulation of rRNA expression POLR2E POLR2F POLR2H H2AX EHMT2 H2AB1 POLR2K H2AC19 POLR2L CHD4 CHD3 TTF1 ACTB H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 BAZ1B H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 DDX21 TAF1D H3C15 MTA1 TAF1B RBBP4 TAF1C TAF1A H2BS1 RBBP7 MTA2 SF3B1 MTA3 GSK3B H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 SMARCA5 H2BC1 DEK GATAD2B GATAD2A MYBBP1A H2AC20 ERCC6 NF-KB ACTIVATION THROUGH FADD RIP-1 PATHWAY MEDIATED BY CASPASE-8 AND -10%REACTOME DATABASE ID RELEASE 76%933543 NF-kB activation through FADD RIP-1 pathway mediated by caspase-8 and -10 FADD IFIH1 IKBKB RNF135 MAVS CHUK DDX58 CASP10 TRIM25 IKBKG CASP8 RIPK1 ORGANIC CATION TRANSPORT%REACTOME DATABASE ID RELEASE 76%549127 Organic cation transport SLC22A18 SLC22A2 SLC22A1 RUNX1 SLC22A4 SLC22A3 RSC1A1 SLC22A15 SLC22A5 SLC22A16 BUTYROPHILIN (BTN) FAMILY INTERACTIONS%REACTOME%R-HSA-8851680.3 Butyrophilin (BTN) family interactions BTNL9 BTNL8 BTN3A1 BTN2A2 BTN2A1 CD209 BTN1A1 BTN3A3 BTNL2 BTN3A2 PPL XDH P75NTR NEGATIVELY REGULATES CELL CYCLE VIA SC1%REACTOME DATABASE ID RELEASE 76%193670 p75NTR negatively regulates cell cycle via SC1 HDAC3 HDAC2 PRDM4 HDAC1 NGF NGFR PROTEIN FOLDING%REACTOME%R-HSA-391251.1 Protein folding HDAC3 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 XRN2 CSNK2B GAPDHS FKBP9 ARL2 GNG10 TBCD TBCC TBCB TBCA GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 TBCE GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA1A TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 GBA GNA14 TUBA3E AP3M1 GNG3 GNA15 TUBA3D GNG2 TUBA3C TUBA4A GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 TUBB4B TUBB4A CCNE2 CCNE1 TP53 ACTB CCT2 CCT7 INTESTINAL SACCHARIDASE DEFICIENCIES%REACTOME%R-HSA-5659898.2 Intestinal saccharidase deficiencies SI LCT ENZYMATIC DEGRADATION OF DOPAMINE BY MONOAMINE OXIDASE%REACTOME DATABASE ID RELEASE 76%379398 Enzymatic degradation of Dopamine by monoamine oxidase MAOA COMT TRAIL SIGNALING%REACTOME DATABASE ID RELEASE 76%75158 TRAIL signaling CFLAR FADD TNFRSF10D CASP10 CASP8 TNFSF10 TNFRSF10B TNFRSF10A VEGF BINDS TO VEGFR LEADING TO RECEPTOR DIMERIZATION%REACTOME%R-HSA-195399.1 VEGF binds to VEGFR leading to receptor dimerization FLT1 FLT4 VEGFB KDR VEGFC VEGFD PGF VEGFA ALTERNATIVE LENGTHENING OF TELOMERES (ALT)%REACTOME%R-HSA-9006821.2 Alternative Lengthening of Telomeres (ALT) DAXX ATRX SUMO IS TRANSFERRED FROM E1 TO E2 (UBE2I, UBC9)%REACTOME DATABASE ID RELEASE 76%3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) RWDD3 SUMO1 SUMO3 UBA2 UBE2I SUMO2 SAE1 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN BCR SIGNALING%REACTOME%R-HSA-8939245.1 RUNX1 regulates transcription of genes involved in BCR signaling ELF1 ELF2 CBFB PAX5 RUNX1 BLK DEFECTIVE ALG2 CAUSES ALG2-CDG (CDG-1I)%REACTOME DATABASE ID RELEASE 76%4549349 Defective ALG2 causes ALG2-CDG (CDG-1i) ALG2 SUMO IS CONJUGATED TO E1 (UBA2:SAE1)%REACTOME%R-HSA-3065676.2 SUMO is conjugated to E1 (UBA2:SAE1) SUMO1 SUMO3 UBA2 SUMO2 SAE1 DISEASES ASSOCIATED WITH GLYCOSAMINOGLYCAN METABOLISM%REACTOME DATABASE ID RELEASE 76%3560782 Diseases associated with glycosaminoglycan metabolism GPC5 GPC4 CHST14 GPC6 CSPG5 ST3GAL3 CSPG4 CHST6 B3GAT3 LUM CHST3 OMD KERA B3GALT6 EXT1 EXT2 OGN SDC1 FMOD AGRN B4GALT7 DCN SLC26A2 B4GALT1 HSPG2 SDC4 BCAN SDC2 HEXB SDC3 HEXA NCAN PRELP PAPSS2 ACAN GPC1 BGN GPC3 VCAN CHSY1 GPC2 SMALL INTERFERING RNA (SIRNA) BIOGENESIS%REACTOME%R-HSA-426486.4 Small interfering RNA (siRNA) biogenesis TSNAX AGO3 PRKRA AGO4 AGO1 AGO2 DICER1 TSN TARBP2 SWITCHING OF ORIGINS TO A POST-REPLICATIVE STATE%REACTOME%R-HSA-69052.3 Switching of origins to a post-replicative state CCNA1 CCNE2 CCNE1 CDK2 RBX1 MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 SKP1 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 VITAMIN B5 (PANTOTHENATE) METABOLISM%REACTOME%R-HSA-199220.2 Vitamin B5 (pantothenate) metabolism PDZD11 PANK4 PANK2 PANK3 PANK1 PPCDC COASY SLC5A6 SLC25A16 VNN1 VNN2 PPCS FASN ENPP2 ENPP1 ENPP3 AASDHPPT DEFECTIVE DHDDS CAUSES RETINITIS PIGMENTOSA 59%REACTOME DATABASE ID RELEASE 76%4755609 Defective DHDDS causes retinitis pigmentosa 59 NUS1 DHDDS IRAK4 DEFICIENCY (TLR5)%REACTOME DATABASE ID RELEASE 76%5603037 IRAK4 deficiency (TLR5) IRAK4 TLR5 MYD88 fliC TLR10 LIGAND-DEPENDENT CASPASE ACTIVATION%REACTOME%R-HSA-140534.5 Ligand-dependent caspase activation MC159L ORF71 TICAM2 LY96 FASLG TICAM1 FAS CD14 TLR4 CASP8 TRADD RIPK1 TRAF2 FADD TNFSF10 TNFRSF10B TNFRSF10A DEFECTIVE MUT CAUSES METHYLMALONIC ACIDURIA MUT TYPE%REACTOME%R-HSA-3359478.1 Defective MUT causes methylmalonic aciduria mut type MMAA MMUT UNWINDING OF DNA%REACTOME%R-HSA-176974.2 Unwinding of DNA CDC45 MCM5 GINS3 MCM6 GINS4 MCM2 MCM7 MCM8 GINS1 MCM3 GINS2 MCM4 MTOR SIGNALLING%REACTOME%R-HSA-165159.6 MTOR signalling PRKAA1 CAB39 CAB39L RPTOR YWHAB STK11 EEF2K AKT2 MLST8 EIF4EBP1 SLC38A9 AKT1 EIF4E EIF4B STRADA STRADB TSC2 TSC1 MTOR RPS6 PPM1A RRAGA RPS6KB1 PRKAB2 RRAGC PRKAA2 RHEB PRKAG1 RRAGB AKT1S1 PRKAG2 RRAGD LAMTOR2 PRKAB1 LAMTOR1 PRKAG3 LAMTOR4 LAMTOR3 LAMTOR5 EIF4G1 FKBP1A COLLAGEN CHAIN TRIMERIZATION%REACTOME DATABASE ID RELEASE 76%8948216 Collagen chain trimerization COL26A1 COL5A3 COL7A1 COL6A2 COL4A3 COL5A2 COL6A1 COL20A1 COL8A2 COL4A6 COL4A5 COL21A1 COL9A1 COL8A1 COL6A3 COL9A3 COL6A6 COL9A2 COL18A1 COL6A5 COL14A1 COL16A1 COL12A1 COL25A1 COL11A1 COL11A2 COL10A1 COL23A1 COL28A1 COL27A1 COL24A1 COL15A1 COL22A1 COL1A1 COL3A1 COL2A1 COL1A2 COL17A1 COL19A1 COL5A1 COL13A1 COL4A2 COL4A1 COL4A4 RAC3 GTPASE CYCLE%REACTOME%R-HSA-9013423.1 RAC3 GTPase cycle ITGB1 CYFIP1 NCKAP1 TRIO TFRC NCF1 NCF2 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 PREX1 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 ERBIN LBR EMD TMPO SWAP70 ARAP2 RAB7A ARAP3 CYBB CYBA OCRL VRK2 LEMD3 VAV2 PIK3R1 BCR TIAM1 RAPGEF1 CDC42EP1 CDC42 DSG2 PAK1 VAMP3 GARRE1 AMIGO2 NOXO1 ARHGAP17 GIT1 PIK3R2 SLC1A5 ARHGAP15 LMAN1 GIT2 ARHGAP21 ABR PGRMC2 RACGAP1 SLITRK3 NHS SLITRK5 VANGL1 DEPDC1B ABL2 NCKAP1L WASF1 SRGAP2 WASF2 EPHA2 YKT6 PAK4 IL32 JAG1 CAV1 MCAM MCF2 BAIAP2 ARHGAP26 MPP7 ARHGAP32 DIAPH3 ABI2 TAOK3 ABI1 NOXA1 NOX3 ESYT1 NOX1 FERMT2 PAK2 LAMTOR1 DEFECTIVE BINDING OF RB1 MUTANTS TO E2F1,(E2F2, E2F3)%REACTOME%R-HSA-9661069.1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) CDKN1C CCNE2 RB1 CCNE1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CDK2 CCND1 CDK4 E2F1 E2F2 E2F3 CDKN1A CDKN1B TRANSCRIPTIONAL REGULATION BY RUNX3%REACTOME DATABASE ID RELEASE 76%8878159 Transcriptional regulation by RUNX3 FOXO3 CREBBP BCL2L11 CBFB HES1 TP53 WWTR1 RUNX1 TCF7L2 SMAD4 TCF7L1 CDKN2A ZFHX3 SMAD3 MDM2 SMURF2 SNW1 CTNNB1 KRAS MAMLD1 EP300 KAT2B KAT2A PSMD8 PSMD9 SPP1 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 JAG1 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 CCND1 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 MAML2 PSMC1 MAML1 PSMC2 RBPJ ITGAL MYC CCN2 TEAD1 TGFB1 TEAD2 SMURF1 TEAD3 TEAD4 BRD2 ITGA4 RUNX3 CDKN1A MAML3 YAP1 HDAC4 NOTCH1 SRC TCF7 LEF1 RNA POLYMERASE II TRANSCRIPTION INITIATION AND PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 76%76042 RNA Polymerase II Transcription Initiation And Promoter Clearance GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 NEGATIVE REGULATORS OF RIG-I MDA5 SIGNALING%REACTOME DATABASE ID RELEASE 76%936440 Negative regulators of RIG-I MDA5 signaling UBA52 IFIH1 UBB RNF135 OTUD5 MAVS NLRX1 UBC UBA7 DDX58 UBE2D2 UBE2D3 TRIM25 RPS27A NLRC5 TNFAIP3 UBE2L6 HERC5 TBK1 RNF216 PCBP2 IKBKE ATG5 ISG15 UBE2D1 ATG12 CYLD RNF125 ITCH IRF3 TRAF3 TAX1BP1 PIN1 UBE2K FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME%R-HSA-140877.2 Formation of Fibrin Clot (Clotting Cascade) TFPI SERPINA5 THBD C1QBP PF4V1 CD177 FGB F2 PF4 FGA A2M SERPIND1 F10 F8 VWF GP1BB KLKB1 F12 F11 FGG GP1BA F3 GP5 F5 F7 PROCR GP9 PROC F9 SERPING1 F13B F2R KNG1 PRTN3 SERPINE2 SERPINC1 PROS1 F13A1 PRCP MATURATION OF PROTEIN E%REACTOME%R-HSA-9683683.2 Maturation of protein E UBB UBA52 UBC RPS27A E DEFECTIVE HLCS CAUSES MULTIPLE CARBOXYLASE DEFICIENCY%REACTOME DATABASE ID RELEASE 76%3371599 Defective HLCS causes multiple carboxylase deficiency PCCB ACACA MCCC2 PC PCCA HLCS MCCC1 RORA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 76%1368082 RORA activates gene expression CREBBP NCOA1 RORA MED1 SREBF1 NCOA2 CPT1A SMARCD3 EP300 CHD9 NCOA6 HELZ2 RXRA TBL1XR1 TGS1 CARM1 TBL1X PPARA EUKARYOTIC TRANSLATION ELONGATION%REACTOME%R-HSA-156842.2 Eukaryotic Translation Elongation RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 EEF1B2 RPL28 EEF1A1 RPS4Y2 EEF1G RPL10 EEF1D RPL12 EEF1A2 RPL11 EEF1A1P5 RPL36A RPS27L EEF2 RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 VITAMIN B2 (RIBOFLAVIN) METABOLISM%REACTOME DATABASE ID RELEASE 76%196843 Vitamin B2 (riboflavin) metabolism FLAD1 SLC52A2 RFK SLC52A3 ENPP1 ACP5 SLC52A1 PLATELET HOMEOSTASIS%REACTOME%R-HSA-418346.2 Platelet homeostasis ATP2A1 SLC8A1 SLC8A2 PPP2R1B PPP2R5E PRKG2 NOS1 TRPC7 GUCY1A2 GUCY1A1 TRPC6 TRPC3 IRAG1 PPP2R5B PLA2G4A PPP2R5A PPP2R5D PPP2R5C FGR STIM1 KCNMA1 PECAM1 ORAI2 ORAI1 PDE9A PDE1B PDE1A ITPR1 ITPR2 GNG10 ITPR3 SRI LRP8 GNAS PPP2CA PPP2CB NOS2 GNG12 PDE11A GNG11 KCNMB1 GNG13 KCNMB2 KCNMB3 GNB2 KCNMB4 APOB GNB1 NOS3 PTGIR PDE2A GNB4 ATP2B4 ATP2B3 GNB3 ATP2B2 PTPN11 ATP2B1 GNB5 PAFAH2 PPP2R1A P2RX7 SLC8A3 GNGT1 P2RX6 P2RX5 P2RX4 GNGT2 PDE10A P2RX3 P2RX2 P2RX1 PTPN6 CALM1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PDE5A MAPK14 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 ACTIVATION OF BMF AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 76%139910 Activation of BMF and translocation to mitochondria MAPK8 BMF DYNLL2 AMINO ACID AND DERIVATIVE METABOLISM%REACTOME DATABASE ID RELEASE 76%71291 Amino acid and derivative metabolism TYRP1 SLC3A2 PPM1K PDHB HSD17B10 DDO SRM CKMT2 CBS TDH SLC25A21 PCBD1 IARS1 CRYM SLC36A4 TXNRD1 SUOX ASS1 BCKDK GSTZ1 TMLHE UROC1 CTH SARDH NAGS SCLY CDO1 TSHB RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 PHYKPL RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 SRR PSAT1 PHGDH SERINC1 SERINC3 SERINC2 SERINC5 PSPH SERINC4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 MCCC2 PSMB10 PSMA8 PSMB6 PSMB7 MCCC1 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PNMT DMGDH MTRR GLDC GLS GCSH IL4I1 HYKK TDO2 CKMT1B GLUL SEPHS2 GAMT PDHX SDS CGA TSTD1 SECISBP2 SLC6A12 SLC6A11 HOGA1 ASRGL1 GCAT MTAP LARS1 ETHE1 IDO2 ALDH7A1 IDO1 GCDH LIPT1 TPH2 SLC45A2 TPH1 SHMT1 SDSL LIAS OAZ1 OAZ2 SLC5A5 ACMSD OAZ3 AFMID NAALAD2 ASL HAO1 RIMKLA RIMKLB PYCR1 PYCR2 PYCR3 TYR ACADSB AIMP1 GLUD1 AIMP2 HAL ALDH6A1 GLUD2 BHMT SLC6A7 SLC6A8 EPRS1 TH PAPSS2 ADI1 PAH KYAT3 OGDH KYAT1 HIBADH SLC44A1 GPT CSAD ADO AUH QARS1 DLAT ENOPH1 AASS ACAD8 ARG2 ARG1 BHMT2 SLC7A5 IVD EEF1E1 DLD OCA2 ECHS1 OAT AHCY KARS1 HDC HAAO ODC1 DLST PAPSS1 DUOX1 RIDA CARNS1 CKB DUOX2 NQO1 CKM AADAT CBSL SQOR BBOX1 FAH AGMAT GNMT ALDH4A1 GATM NDUFAB1 OTC FOLH1B HNMT SAT1 TXN2 IYD SLC25A44 RARS1 HGD DIO1 DIO2 PIPOX DIO3 MAT1A KMO FOLH1 SMS NNMT ASMT MRI1 ACAT1 TPO AANAT AMDHD1 PRODH MPST EEFSEC PDHA2 PDHA1 GOT1 AGXT2 GOT2 ASNS AZIN2 NMRAL1 AZIN1 QDPR SEPSECS GRHPR DAO CPS1 PXMP2 SLC25A2 TAT AMD1 GADL1 APIP MTR DBH FTCD DHTKD1 KYNU DBT HIBCH PSTK BCKDHA BCKDHB MARS1 AMT PRODH2 DARS1 INMT SLC25A15 SARS1 TST DCT CHDH ASPG SLC25A10 SLC25A12 BCAT1 NAT8L AGXT ASPA SLC25A13 BCAT2 ALDH9A1 PAOX DDC CARNMT1 GLS2 SODIUM CALCIUM EXCHANGERS%REACTOME DATABASE ID RELEASE 76%425561 Sodium Calcium exchangers SLC8A3 SLC8A1 SLC8A2 CALM1 SLC24A2 SLC24A1 SLC24A4 SLC24A3 SRI SLC8B1 FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION%REACTOME%R-HSA-983231.2 Factors involved in megakaryocyte development and platelet production DOCK10 KIF28P KDM1A JMJD1C DOCK11 KIF5C KIF5B KIF5A MYB KIF21A RAB5A KIF21B KIFAP3 IFNA13 IFNA14 IFNA16 IFNA17 HBE1 KIF16B KIF20A KIF20B ZFPM1 IFNA10 PRKACA GATA6 GATA5 CDC42 AK3 GATA4 GATA3 KLC1 GATA2 GATA1 PHF21A KLC4 KLC3 KLC2 KIF3B MICAL1 ABL1 RACGAP1 KIF3C IFNA21 CARMIL1 NFE2 CBX5 HBG2 HBG1 EHD1 EHD2 EHD3 KIF18A KIF18B CDK5 KIF4B MAFG KIF4A MAFF MAFK RCOR1 DOCK6 IFNA5 DOCK5 IFNA4 DOCK4 IFNA7 DOCK3 IFNA6 DOCK9 DOCK8 DOCK7 IFNA2 PRKAR2B HBB KIF12 HBD KIF11 IFNA8 KIF15 AKAP10 KIF19 CAPZB SIN3A KIF13B HMG20B KIF1C KIF1B RAC1 KIF1A JAK2 ITPK1 KIF25 KIF23 KIF22 RBSN KIF6 KIF27 RAD51B KIF9 RAD51C KIF2A KIFC2 KIFC1 IRF1 IRF2 TP53 KIF2C KIF2B DOCK2 DOCK1 CDK2 AKAP1 MFN1 MFN2 SH2B3 SH2B2 PRKACG SH2B1 PRKACB IFNB1 CABLES1 CABLES2 CENPE WEE1 KIF26A PRKAR1B KIF26B CAPZA1 PRKAR1A CAPZA2 VPS45 KIF3A PRKAR2A H3-3B H3C8 HDAC2 HDAC1 H3C15 KETONE BODY METABOLISM%REACTOME DATABASE ID RELEASE 76%74182 Ketone body metabolism ACAT1 HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS BIOSYNTHESIS OF ELECTROPHILIC Ω-3 PUFA OXO-DERIVATIVES%REACTOME%R-HSA-9027604.1 Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives ALOX5 PTGS2 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5619101.1 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 PACKAGING OF EIGHT RNA SEGMENTS%REACTOME%R-HSA-168303.3 Packaging of Eight RNA Segments PA PB2 NP NA NS HA M PB1 SUPPRESSION OF PHAGOSOMAL MATURATION%REACTOME%R-HSA-9637687.1 Suppression of phagosomal maturation secA2 NOS2 UBB VPS33B PPE2 lprG UBC HGS RPS27A RAB5A KPNB1 RAB7A CORO1A lpdC esxH esxG UBA52 Rv1410c ATP6V1H sapM ndkA KPNA1 ptpA REGULATION OF BACH1 ACTIVITY%REACTOME%R-HSA-9708530.1 Regulation of BACH1 activity RBX1 UBB UBA52 UBC MAFK RPS27A FBXL17 SKP1 CUL1 BACH1 SKP2 LIPOPROTEIN METABOLISM%REACTOME%R-HSA-174824.4 Lipoprotein metabolism NR1H2 A2M PRKACG PRKACB APOB HDLBP PCSK9 CLTA CLTC AP2A1 ZDHHC8 VLDLR PCSK6 AP2A2 LIPA PRKACA PCSK5 LIPC CREB3L3 LIPG LDLRAP1 FURIN AP2M1 CUBN MYLIP AMN APOA2 APOA1 APOA4 LSR APOA5 SOAT1 NPC1 SOAT2 NPC2 ANGPTL8 ANGPTL3 ANGPTL4 LPA CES3 ABCG1 CETP SAR1B MTTP LPL LCAT LMF2 LMF1 APOF AP2S1 APOE LDLR FGF21 GPIHBP1 ABCA1 MBTPS1 APOC4 APOC3 NR1H3 APOBR AP2B1 NCEH1 APOC2 APOC1 ALB P4HB MBTPS2 FORMATION OF TC-NER PRE-INCISION COMPLEX%REACTOME DATABASE ID RELEASE 76%6781823 Formation of TC-NER Pre-Incision Complex RBX1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 GTF2H3 EP300 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 GPS1 UBA52 COPS4 COPS2 ERCC6 UBB UBC ISY1 RPS27A PRPF19 HMGN1 USP7 AQR DDB1 PPIE ZNF830 XPA COPS7B COPS7A CUL4A COPS3 XAB2 COPS6 COPS5 UVSSA ERCC8 TCEA1 COPS8 CUL4B SIGNALING BY NODAL%REACTOME DATABASE ID RELEASE 76%1181150 Signaling by NODAL GDF1 FOXO3 ACVR1B ACVR2B ACVR2A CFC1 SMAD4 DRAP1 ACVR1C TDGF1P3 SMAD3 LEFTY2 TDGF1 DAND5 NODAL CER1 PCSK6 FURIN SMAD2 LEFTY1 FOXH1 INTESTINAL INFECTIOUS DISEASES%REACTOME DATABASE ID RELEASE 76%8942233 Intestinal infectious diseases GUCY2C PDZD3 sta1 SYNTHESIS OF 12-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME DATABASE ID RELEASE 76%2142712 Synthesis of 12-eicosatetraenoic acid derivatives GPX2 GPX1 GPX4 ALOX15 ALOX12 ALOX12B ALOXE3 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9694548.1 Maturation of spike protein ST3GAL3 ST6GALNAC2 RPN2 PRKCSH TUSC3 RPN1 MAGT1 FUT8 GANAB S MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 TRANSPORT OF VITAMINS, NUCLEOSIDES, AND RELATED MOLECULES%REACTOME%R-HSA-425397.3 Transport of vitamins, nucleosides, and related molecules APOD SLC16A2 SLC35A2 SLC35A1 SLC35A3 SLC35C1 SLC33A1 PDZD11 SLCO1C1 ARL2BP SLCO4A1 SLCO4C1 SLCO2A1 SLCO1A2 LCN1 AVP SLC27A6 SLC29A4 SLC25A5 SLC29A1 SLC28A2 SLC25A4 SLC28A1 SLC29A3 SLC25A6 SLC27A4 SLC29A2 SLC28A3 ARL2 ALB SLC5A6 SLC35B3 SLC35B2 LCN9 SLC27A1 SLC35B4 SLC35D1 SLC35D2 SLCO1B1 LCN15 SLCO2B1 LCN12 SLCO1B3 RND3 GTPASE CYCLE%REACTOME%R-HSA-9696264.1 RND3 GTPase cycle ARHGAP21 DST TXNL1 VANGL1 DEPDC1B DLG5 EPHA2 ROCK1 CAV1 DDX4 TNFAIP1 ARHGAP5 RND3 ARHGAP35 FLOT2 MUC13 RBMX FAM83B DSP CKB ANKRD26 PLEKHG5 TMOD3 SEMA4F SCRIB PTPN13 CKAP4 KTN1 NISCH RASAL2 CCDC88A VANGL2 UBXN11 CPD KCTD13 DSG1 PKP4 LEMD3 PICALM PIK3R1 WDR6 PIK3R2 DEFECTIVE FMO3 CAUSES TMAU%REACTOME DATABASE ID RELEASE 76%5579019 Defective FMO3 causes TMAU FMO3 RNA POLYMERASE I TRANSCRIPTION INITIATION%REACTOME%R-HSA-73762.3 RNA Polymerase I Transcription Initiation POLR1H HDAC2 HDAC1 TAF1D MTA1 TAF1B RBBP4 TAF1C TAF1A RBBP7 MTA2 MTA3 MBD3 CCNH POLR2E POLR2F POLR2H GATAD2B GATAD2A EHMT2 POLR2K POLR2L ERCC6 CHD4 CHD3 GTF2H1 TTF1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 RRN3 KAT2B UBTF KAT2A POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G MEMBRANE TRAFFICKING%REACTOME DATABASE ID RELEASE 76%199991 Membrane Trafficking F8 KIF28P KIF5C KIF5B KIF5A HGS RAB5A KIF21A YWHAE KIF21B KIFAP3 RAB7A ACTR1A KIF16B KIF20A KIF20B RAB8A YWHAG KLC1 KLC4 KLC3 KLC2 KIF3B KIF3C CSNK1D DYNLL1 KIF18A KIF18B KIF4B UBA52 KIF4A OPTN PAFAH1B1 DYNC1I2 DCTN2 DCTN3 UBB KIF12 UBC KIF11 RPS27A KIF15 KIF19 CAPZB KIF13B DYNC1H1 KIF1C KIF1B RAC1 KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 KIF9 KIF2A KIFC2 KIFC1 KIF2C KIF2B CENPE KIF26A KIF26B CAPZA1 CAPZA2 VPS45 CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 SAR1B AP2S1 LDLR AP2B1 COPS7B COPS7A COPS3 COPS6 COPS5 COPS8 APP MAN2A1 AGTR1 CPD PICALM ITSN2 USP6NL SCOC ITSN1 FNBP1L RABGEF1 GJA1 GJA3 TFG GJA5 AKT3 GJA4 AP1S2 AP1S1 GJA9 AP1S3 GJA8 TACR1 VPS36 GABARAPL2 FNBP1 SYTL1 GAPVD1 DYNC1LI1 DYNC1LI2 BIN1 AVP VPS25 VPS28 PLA2G6 GNS GABARAP GJC1 BLOC1S4 BLOC1S6 GJC2 BLOC1S1 BLOC1S3 VTI1A SFN PIP5K1C SNAPIN CCZ1B FZD4 RAB3IP LNPEP SNF8 GJB2 GJB1 GJB4 GJB3 GJB6 GJB5 GJB7 ARF3 DENND1C DENND1B ARF4 ARF1 SERPINA1 DENND1A ARPC1A CLTB STON1 CHM STON2 CLINT1 AREG AP3S1 SLC18A3 DENND2D DENND2C EXOC8 EXOC7 DENND2B DENND2A COPZ2 RAB3IL1 EPS15L1 COPZ1 GJD2 VAMP8 GJD4 GJD3 VAMP7 EXOC4 EXOC3 CHRM2 EXOC6 EXOC5 VAMP4 PAFAH1B3 EXOC2 VAMP2 PAFAH1B2 ARF5 EXOC1 HBEGF ARF6 NBAS TMF1 USO1 EGFR AKT2 GGA2 GGA1 ARFRP1 GGA3 LMAN2 STX6 STX5 STX4 CHML TSC2 RIC1 TSC1 TRAPPC10 ARCN1 SNX18 UBAP1 RAB3A ADRB2 GOLIM4 RAB43 RAB41 TPD52 RALGAPA2 RAB32 RINT1 RAB30 RALGAPB RAB31 RAB36 RAB35 RAB38 FTL GRIA1 RAB5B RAB5C ARL1 RHOBTB3 CLTCL1 DVL2 AP4S1 RAB6A KIAA0319 RAB6B AP1M2 COL7A1 AP1M1 TXNDC5 TRAPPC2 ANKRD28 TRAPPC3 SEC16B RAB4A TOR1A TRAPPC1 ANKRD27 TRAPPC4 SEC16A TRAPPC5 HPS1 HPS4 M6PR ARPC4 TFRC TRAPPC8 SYNJ2 ARPC5 TRAPPC9 SNAP23 TOR1B DAB2 CNIH1 SYNJ1 ARPC2 ARPC3 AAK1 CNIH2 CNIH3 MCFD2 ARRB1 ARRB2 PIK3C2A BICD1 BICD2 AP4M1 PPP6C AP1G2 AP1G1 PPP6R1 PPP6R3 SNAP29 AVPR2 SH3D19 ACTR2 SGIP1 OCRL VPS37C VPS37D VPS37A VPS37B ARFGAP3 SPTB ARFGAP1 BET1L VAMP3 ARFGAP2 DNAJC6 SEC22B SEC22A SEC22C RAB1A SEC23A VPS4B LMAN1 RAB1B VPS4A DENND3 LRP2 RAB21 RACGAP1 FCHO1 VPS51 VPS53 FCHO2 VPS52 UBQLN1 VPS54 UBQLN2 YKT6 SEC24B SEC24A HIP1R TPD52L1 RAB10 NECAP2 MYO1C NECAP1 RAB14 SYT11 RAB12 RAB13 RAB18 SEC24D SEC24C FOLR1 BET1 KDELR1 GCC2 GCC1 GOLGA2 GOLGA4 GOLGA5 RINL FTH1 GOLGA1 TBC1D10C ARFIP2 TBC1D10A AGFG1 TBC1D10B COG8 COG7 COG6 LMAN1L COG5 COG4 COG3 AP1B1 COG2 COG1 ANK2 ANK3 ANK1 EREG BTC ZW10 ULK1 PREB RIN3 KDELR2 KDELR3 RIN1 RIN2 CFTR SPTBN4 SPTBN5 STXBP3 LMAN2L TGFA TGOLN2 SCFD1 SNX2 GJA10 SNX9 SNX5 SEC31A SPTBN2 TBC1D8B SURF4 RAB39A MYO5A RAB27A RAB39B RAB27B STAM PUM1 SNAP91 TF MON1A MON1B C2CD5 HIP1 GDI1 SH3KBP1 CTSZ GDI2 AP4E1 MIA2 MIA3 CD3G CD3D MAP1LC3B TMED3 TMED2 TMED7 CTSC RAB8B SEC13 TMED9 AP3B1 RAB33A RAB33B GAK CTTN RAB7B RHOQ NAPA NAPB RABGAP1 STX17 STX16 STX18 NEDD8 NAPG STX10 ALS2CL CUX1 CD59 EPS15 DYNC1I1 CD55 SORT1 GBF1 RAB11A RAB11B TJP1 RGP1 SEC23IP EPGN CAPZA3 TRIP10 YIPF6 F5 TRIP11 RAB3GAP2 RAB9A COPG2 COPG1 ACTR10 RAB9B RAB3GAP1 SCARB2 SH3GL3 SYS1 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 SBF1 SBF2 SH3GL2 SH3GL1 NSF TRAPPC2L WNT5A TBC1D20 TBC1D24 CHMP4C CHMP4B AMPH DENND6B CHMP4A DENND6A STAM2 COPB2 COPA TMED10 TSG101 COPB1 SPTA1 GRK3 GRK2 MAN2A2 PACSIN2 TBC1D13 PACSIN3 TBC1D14 TBC1D17 TBC1D15 PACSIN1 TBC1D16 SYT2 SYT1 DENND4B DENND4A VTA1 DENND4C ASPSCR1 CCZ1 SYT9 AP4B1 SYT8 IGF2R PLA2G4A TMEM115 ALPP CHMP2B CHMP2A ACBD3 COPE SLC2A4 USE1 RABEPK SLC2A8 YWHAQ MAN1A2 MAN1A1 YWHAH NAA30 EPN1 DNM1 DNM2 CD4 EPN2 DNM3 TBC1D1 TRAPPC6A TBC1D2 HSPA8 RABEP1 PRKAB2 APOB TBC1D3 PRKAA2 TBC1D4 PRKAG1 ALS2 PLIN3 TRAPPC6B PRKAG2 GORASP1 TBC1D7 PRKAB1 MYH9 PRKAG3 CHMP3 NAA35 CLTC DNASE2 WASL NAA38 CHMP6 CHMP7 CHMP5 DCTN6 DCTN5 RALA DCTN1 GOSR2 CALM1 DCTN4 GOSR1 SPTAN1 CBL DYNLL2 AGPAT3 SPTBN1 INS CYTH3 CYTH2 CYTH4 MVB12B REPS2 CLVS2 BNIP1 MAN1C1 MVB12A CYTH1 REPS1 CLVS1 GALNT2 EGF GALNT1 DTNBP1 YWHAB AKT1 YWHAZ KIF3A GPS1 COPS4 COPS2 MYO6 BIOSYNTHESIS OF D-SERIES RESOLVINS%REACTOME%R-HSA-9018676.1 Biosynthesis of D-series resolvins ALOX5 LTA4H HPGD SODIUM PROTON EXCHANGERS%REACTOME%R-HSA-425986.1 Sodium Proton exchangers SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 IRF3 MEDIATED ACTIVATION OF TYPE 1 IFN%REACTOME%R-HSA-1606341.2 IRF3 mediated activation of type 1 IFN IRF3 ZBP1 NLRP4 DTX4 TBK1 ERKS ARE INACTIVATED%REACTOME DATABASE ID RELEASE 76%202670 ERKs are inactivated DUSP6 PPP2CA DUSP7 PPP2CB MAPK7 PPP2R1B PPP2R5D PPP2R1A MAPK1 MAPK3 DUSP4 DUSP3 VRK3 REGULATION OF MECP2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 76%9022692 Regulation of MECP2 expression and activity HDAC3 HDAC2 HDAC1 AGO3 AGO4 AGO1 AGO2 CAMK2B CAMK2D FOXG1 CAMK2A GPS2 LBR HTT AURKB CAMK2G HIPK2 TBL1XR1 SIN3A NCOR2 TNRC6C TBL1X MOV10 CREB1 NCOR1 CAMK4 TNRC6A TNRC6B PRKACA CALM1 DEFECTIVE MMAA CAUSES METHYLMALONIC ACIDURIA TYPE CBLA%REACTOME%R-HSA-3359475.1 Defective MMAA causes methylmalonic aciduria type cblA MMAA MMUT N-GLYCAN TRIMMING AND ELONGATION IN THE CIS-GOLGI%REACTOME DATABASE ID RELEASE 76%964739 N-glycan trimming and elongation in the cis-Golgi MGAT1 MANEA MAN1C1 MAN1A2 MAN1A1 DEGRADATION OF GLI1 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 76%5610780 Degradation of GLI1 by the proteasome PRKACG PRKACB RBX1 GLI1 SUFU NUMB BTRC PRKACA ITCH SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PASSIVE TRANSPORT BY AQUAPORINS%REACTOME%R-HSA-432047.1 Passive transport by Aquaporins MIP AQP11 AQP12A AQP8 AQP10 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 HS-GAG BIOSYNTHESIS%REACTOME%R-HSA-2022928.1 HS-GAG biosynthesis GPC5 GPC4 HS3ST3A1 HS6ST1 GPC6 HS6ST2 HS2ST1 HS6ST3 NDST2 NDST1 NDST4 NDST3 HS3ST3B1 EXT1 GLCE EXT2 HS3ST5 HS3ST6 SDC1 HS3ST4 HS3ST1 AGRN HS3ST2 HSPG2 SDC4 SDC2 SDC3 SLC35D2 GPC1 GPC3 GPC2 SMAD2 3 PHOSPHORYLATION MOTIF MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%3304356 SMAD2 3 Phosphorylation Motif Mutants in Cancer TGFB1 SMAD3 TGFBR1 TGFBR2 SMAD2 IRAK4 DEFICIENCY (TLR2 4)%REACTOME DATABASE ID RELEASE 76%5603041 IRAK4 deficiency (TLR2 4) IRAK4 MYD88 FGB LY96 FGA CD14 TLR4 TLR1 FGG S100A1 HMGB1 S100A9 TIRAP S100A8 mip TLR2 BTK porB TLR6 CD36 BILE ACID AND BILE SALT METABOLISM%REACTOME DATABASE ID RELEASE 76%194068 Bile acid and bile salt metabolism RXRA SLCO1A2 AKR1D1 HSD17B4 CYP46A1 ABCB11 CYP7A1 OSBP OSBPL9 ABCC3 NCOA1 HSD3B7 ACOT8 OSBPL7 NCOA2 OSBPL6 ALB PTGIS STARD5 SLC10A1 AKR1C1 OSBPL3 SLC10A2 OSBPL2 AKR1C3 NR1H4 AKR1C2 AKR1C4 BAAT CYP7B1 CYP8B1 CYP27A1 CYP39A1 CH25H AMACR ACOX2 FABP6 OSBPL1A SLCO1B1 SLC27A2 SLC27A5 SLCO1B3 AMINE LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-375280.2 Amine ligand-binding receptors HTR1F HTR1D HTR1A HTR1B CHRM2 ADRB3 CHRM3 CHRM1 CHRM4 CHRM5 HTR2B HTR5A HTR2C ADRA1D HTR2A HTR4 ADRA1B ADRA1A HTR6 HTR7 ADRB1 ADRB2 TAAR8 TAAR9 TAAR6 TAAR5 TAAR3P TAAR2 HRH1 ADRA2C HRH3 TAAR1 ADRA2B HRH2 ADRA2A HRH4 DRD1 DRD2 DRD3 DRD4 DRD5 GPR143 HTR1E CLASS C 3 (METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS)%REACTOME DATABASE ID RELEASE 76%420499 Class C 3 (Metabotropic glutamate pheromone receptors) TAS2R40 TAS2R8 TAS2R41 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM1 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS1R2 TAS2R1 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 GABBR2 CASR GABBR1 TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R38 TAS2R39 TAS2R19 TAS2R60 TAS2R7 TAS2R9 IMATINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 76%9674396 Imatinib-resistant PDGFR mutants PDGFRA SUMOYLATION OF IMMUNE RESPONSE PROTEINS%REACTOME%R-HSA-4755510.3 SUMOylation of immune response proteins IKBKE NFKBIA RELA TOPORS IKBKG NFKB2 PIAS4 SUMO1 PIAS3 SUMO3 UBE2I DEFECTIVE CYP26C1 CAUSES FFDD4%REACTOME DATABASE ID RELEASE 76%5579004 Defective CYP26C1 causes FFDD4 CYP26C1 DEFECTIVE SLC34A1 CAUSES HYPOPHOSPHATEMIC NEPHROLITHIASIS OSTEOPOROSIS 1 (NPHLOP1)%REACTOME DATABASE ID RELEASE 76%5619040 Defective SLC34A1 causes hypophosphatemic nephrolithiasis osteoporosis 1 (NPHLOP1) SLC34A1 TRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-6785470.4 tRNA processing in the mitochondrion HSD17B10 TRMT10C PRORP ELAC2 TRNT1 PTK6 REGULATES RTKS AND THEIR EFFECTORS AKT1 AND DOK1%REACTOME DATABASE ID RELEASE 76%8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 PTK6 UBB ARAP1 UBA52 UBC RPS27A CBL AKT1 DOK1 XAV939 STABILIZES AXIN%REACTOME DATABASE ID RELEASE 76%5545619 XAV939 stabilizes AXIN TNKS2 TNKS VLDL ASSEMBLY%REACTOME%R-HSA-8866423.3 VLDL assembly MTTP APOC1 P4HB APOB APOC4 ORGANIC ANION TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%428643 Organic anion transporters SLC25A10 SLC5A8 SLC5A5 SLC25A18 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A1 SLC25A22 CA2+ PATHWAY%REACTOME%R-HSA-4086398.3 Ca2+ pathway PRKG1 PLCB3 PLCB1 PLCB2 NLK TCF7L2 PRKG2 PPP3R1 WNT11 TCF7L1 PDE6B PDE6A FZD3 FZD5 PDE6G CTNNB1 FZD6 NFATC1 GNAO1 AGO3 AGO4 AGO1 AGO2 ITPR1 ITPR2 GNG10 ITPR3 FZD4 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 CALM1 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 PRKCA CAMK2A WNT5A TNRC6C MOV10 TNRC6A TNRC6B PPP3CA PPP3CB GNAT2 TCF7 MAP3K7 LEF1 COOPERATION OF PREFOLDIN AND TRIC CCT IN ACTIN AND TUBULIN FOLDING%REACTOME DATABASE ID RELEASE 76%389958 Cooperation of Prefoldin and TriC CCT in actin and tubulin folding PFDN5 PFDN6 TUBAL3 CCT6B TUBB6 TUBA3E TUBB3 TUBB1 TUBA3D TUBA3C CCT2 TUBA4A CCT8 CCT5 CCT4 TUBA4B CCT7 ACTB CCT6A TUBA1A TUBA8 TUBA1C TUBB4B TUBA1B TUBB4A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 EPHRIN SIGNALING%REACTOME DATABASE ID RELEASE 76%3928664 Ephrin signaling PAK2 ARHGEF7 EPHB6 MYL12A EFNB2 RAC1 EFNB1 SDCBP EFNB3 FYN PAK3 PAK1 EPHB2 NCK2 EPHB1 EPHB4 EPHB3 GIT1 ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT (ESCRT)%REACTOME%R-HSA-917729.1 Endosomal Sorting Complex Required For Transport (ESCRT) VPS4A MVB12B VPS36 MVB12A VTA1 VPS25 VPS28 CHMP2B CHMP2A UBA52 STAM UBB SNF8 UBC UBAP1 HGS RPS27A CHMP4C CHMP4B CHMP3 CHMP4A VPS37C VPS37D STAM2 VPS37A CHMP6 VPS37B CHMP7 CHMP5 TSG101 VPS4B MUSCARINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 76%390648 Muscarinic acetylcholine receptors CHRM5 CHRM2 CHRM3 CHRM1 CHRM4 GAMMA-CARBOXYLATION, TRANSPORT, AND AMINO-TERMINAL CLEAVAGE OF PROTEINS%REACTOME DATABASE ID RELEASE 76%159854 Gamma-carboxylation, transport, and amino-terminal cleavage of proteins F7 PROC F2 F9 F10 FURIN GGCX BGLAP PROS1 PROZ GAS6 MITOCHONDRIAL TRANSLATION ELONGATION%REACTOME%R-HSA-5389840.1 Mitochondrial translation elongation MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPS18B MRPL49 MRPS18A MRPS2 MRPS21 MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPL44 TUFM MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 DIGESTION OF DIETARY CARBOHYDRATE%REACTOME DATABASE ID RELEASE 76%189085 Digestion of dietary carbohydrate CHIT1 MGAM CHIA SI AMY2A LCT AMY1A AMY2B TREH AMY1B AMY1C HIV TRANSCRIPTION ELONGATION%REACTOME DATABASE ID RELEASE 76%167169 HIV Transcription Elongation CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TCEA1 RAS ACTIVATION UPON CA2+ INFLUX THROUGH NMDA RECEPTOR%REACTOME DATABASE ID RELEASE 76%442982 Ras activation upon Ca2+ influx through NMDA receptor CAMK2B CAMK2D HRAS CAMK2A CAMK2G NRAS ACTN2 RASGRF2 RASGRF1 GRIN2B GRIN1 GRIN2D DLG1 DLG2 CALM1 DLG3 LRRC7 DLG4 NEFL METABOLISM OF FAT-SOLUBLE VITAMINS%REACTOME DATABASE ID RELEASE 76%6806667 Metabolism of fat-soluble vitamins GPC5 APOA1 GPC4 APOA4 LRP2 GPC6 SDC1 AGRN LPL APOE LDLR GPIHBP1 APOC3 VKORC1L1 LRP8 UBIAD1 LRP1 RETSAT PLB1 APOC2 TTR APOM RDH11 TTPA APOB LRAT BCO2 AKR1C1 BCO1 VKORC1 RBP4 AKR1C3 CLPS AKR1B10 RBP2 AKR1C4 RBP1 LRP10 PNLIP LRP12 HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 APOA2 G1 S DNA DAMAGE CHECKPOINTS%REACTOME%R-HSA-69615.2 G1 S DNA Damage Checkpoints CCNA1 CCNE2 CCNE1 TP53 COP1 PCBP4 CDKN2A CDK2 MDM2 ATM MDM4 CHEK1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 EUKARYOTIC TRANSLATION TERMINATION%REACTOME DATABASE ID RELEASE 76%72764 Eukaryotic Translation Termination RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 N6AMT1 APEH RPL4 TRMT112 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 GSPT1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 DISORDERS OF TRANSMEMBRANE TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%5619115 Disorders of transmembrane transporters DERL1 DERL2 SLC3A2 SLC3A1 RNF5 ERLEC1 OS9 NUP42 NUP43 RAE1 RANBP2 SLC12A3 SLC16A1 KCNJ11 SLC12A1 GCK NUP35 RHAG NUP37 SLC24A1 SLC24A4 AVPR2 SLCO1B1 SLCO1B3 SLC35A2 SLC35A1 SLC35A3 SLC35C1 SLC33A1 SLCO2A1 UBA52 SLC9A6 SLC29A3 SLC27A4 SLC9A9 NUP214 UBB SLC5A5 UBC RPS27A BSG SLC26A2 AVPR1B CFTR AVPR1A AVP ABCB11 SLC6A20 SEC13 NUP107 NUP188 SLC4A1 ABCA12 SLC4A4 PSMD8 SLC12A6 PSMD9 SLC39A4 PSMD6 SLC34A3 APOA1 PSMD7 ABCG8 PSMD4 SLC34A2 ABCG5 PSMD5 SLC6A19 PSMD2 SLC6A18 PSMD3 NUP210 PSMD1 SLC6A14 SLC11A2 PSMA5 NUP93 PSMA6 SLC5A7 VCP PSMA3 POM121 PSMA4 NUP205 PSMA1 ABCB6 PSMA2 PSME3 ABCB4 PSME4 SEL1L PSME1 SLC1A1 PSME2 SLC1A3 PSMD10 SLC5A1 AAAS PSMB11 PSMD12 SLC5A2 PSMD11 NUP160 PSMD14 POM121C PSMD13 NUP85 TPR NUP88 PSMA7 ABCA1 GCKR PSMB10 NUP155 PSMA8 ABCA3 PSMB6 ERLIN1 PSMB7 NUP153 PSMB4 ERLIN2 PSMB5 CP PSMB2 SLC2A9 PSMB3 SLC6A5 PSMB1 PSMF1 SLC26A4 SLC26A3 RNF185 PSMB8 ABCD4 PSMB9 SEM1 SLC2A1 SLC40A1 PSMC5 SLC34A1 SLC2A2 PSMC6 SLC6A2 PSMC3 SLC6A3 PSMC4 HK1 PSMC1 SLC22A5 SLC22A12 PSMC2 HEPH SLC22A18 NUP62 ABCD1 NDC1 ABCC2 SLC36A2 NUP133 ABCC8 SLC17A5 SLC2A10 ABCC6 ABCC9 SLC17A8 SLC7A7 SLC7A9 NUP50 NUP54 SLC20A2 DERL3 RHOG GTPASE CYCLE%REACTOME%R-HSA-9013408.1 RHOG GTPase cycle DOCK2 DOCK1 ITGB1 CYFIP1 ANKLE2 TRIO TFRC ARHGDIG ARHGDIA MCF2L VAV3 PLEKHG3 ARHGAP1 ARHGEF16 RHOG ARHGAP39 VAV1 ARHGAP5 NDUFS3 ELMO2 ARHGAP35 ARHGEF5 ARHGEF26 PREX1 SHMT2 PLD1 IQGAP2 KALRN OPHN1 NDUFA5 STBD1 HSPE1 ARHGDIB LETM1 ERBIN VAPB LBR MAP3K11 EMD TMPO RAB7A VRK2 LEMD3 VAV2 PIK3R1 ARFGAP3 CDC42EP1 CDC42 DSG2 VAMP3 GARRE1 LMAN1 ARHGAP21 PGRMC2 VANGL1 DEPDC1B EPHA2 YKT6 PAK4 CAV1 MCAM MCF2 MPP7 ARHGAP32 DIAPH3 DOCK5 DOCK4 DOCK3 ESYT1 STX5 PAK2 KTN1 LAMTOR1 ITSN1 INHIBITION OF TSC COMPLEX FORMATION BY PKB%REACTOME%R-HSA-165181.2 Inhibition of TSC complex formation by PKB TSC2 TSC1 AKT2 CLEAVAGE OF THE DAMAGED PYRIMIDINE%REACTOME DATABASE ID RELEASE 76%110329 Cleavage of the damaged pyrimidine H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 NTHL1 TDG MBD4 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 SMUG1 H2BC12 NEIL3 H2BC13 NEIL2 H3-4 H2BC14 POT1 H2AJ TERF2IP NEIL1 H2BC15 H2BC11 RIP-MEDIATED NFKB ACTIVATION VIA ZBP1%REACTOME DATABASE ID RELEASE 76%1810476 RIP-mediated NFkB activation via ZBP1 IKBKB MYD88 CHUK NFKBIA RELA TICAM1 NFKB2 IKBKG RIPK1 RIPK3 DHX9 NFKB1 ZBP1 NKIRAS1 NKIRAS2 TLR3 NFKBIB HSP90 CHAPERONE CYCLE FOR SHRS%REACTOME DATABASE ID RELEASE 76%3371497 HSP90 chaperone cycle for SHRs DNAJB1 HSPA1L PTGES3 NR3C1 HSPA2 DNAJA1 DYNC1I1 DNAJA4 NR3C2 DNAJA2 FKBP4 HSPA1B FKBP5 DYNLL1 AR DYNC1LI1 DYNC1LI2 CAPZA3 PGR CAPZA1 CAPZA2 ACTR10 DYNC1I2 DCTN2 DCTN3 HSP90AA1 HSPA8 CAPZB ACTR1A DYNC1H1 DCTN6 DCTN5 DCTN1 HSPA1A DCTN4 DYNLL2 HSP90AB1 STIP1 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME DATABASE ID RELEASE 76%4793953 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) B4GALT1 INTERLEUKIN-23 SIGNALING%REACTOME DATABASE ID RELEASE 76%9020933 Interleukin-23 signaling JAK2 P4HB STAT3 IL23A IL23R STAT4 IL12B TYK2 IL12RB1 LIPID PARTICLE ORGANIZATION%REACTOME DATABASE ID RELEASE 76%8964572 Lipid particle organization HILPDA CIDEA FITM1 FITM2 HSD17B13 CIDEC DEFECTIVE LFNG CAUSES SCDO3%REACTOME DATABASE ID RELEASE 76%5083630 Defective LFNG causes SCDO3 NOTCH2 LFNG NOTCH3 NOTCH4 NOTCH1 EPHB-MEDIATED FORWARD SIGNALING%REACTOME DATABASE ID RELEASE 76%3928662 EPHB-mediated forward signaling ROCK1 ROCK2 ARPC4 FYN ARPC5 GRIN2B GRIN1 ARHGEF28 ARPC1B ARPC2 ACTG1 ARPC3 CFL1 LYN YES1 LIMK2 LIMK1 KALRN PTK2 ACTB HRAS RASA1 ACTR2 ARPC1A WASL RAC1 TIAM1 CDC42 SDC2 PAK1 ITSN1 RHOA APC C:CDC20 MEDIATED DEGRADATION OF CYCLIN B%REACTOME DATABASE ID RELEASE 76%174048 APC C:Cdc20 mediated degradation of Cyclin B UBB CDC20 UBC RPS27A ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 UBA52 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDK1 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 CCNB1 TRIGLYCERIDE METABOLISM%REACTOME%R-HSA-8979227.1 Triglyceride metabolism LPIN2 LPIN3 MGLL PRKACG PRKACB CAV1 GK3P MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 PLIN3 PPP1CC PPP1CB LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 PRKACA FABP2 FABP3 FABP4 GPAM FABP5 FABP6 GPD2 FABP7 PNPLA4 PNPLA5 PLIN1 LPIN1 ATTACHMENT AND ENTRY%REACTOME%R-HSA-9694614.2 Attachment and Entry ACE2 TMPRSS2 7a N 3a CTSL M E FURIN VCP S CONSTITUTIVE SIGNALING BY LIGAND-RESPONSIVE EGFR CANCER VARIANTS%REACTOME%R-HSA-1236382.1 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants UBB HSP90AA1 CDC37 HRAS UBC SHC1 GAB1 RPS27A PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 UBA52 EGFR CBL SIGNALING BY TCF7L2 MUTANTS%REACTOME DATABASE ID RELEASE 76%5339700 Signaling by TCF7L2 mutants TCF7L2 CTBP2 CTBP1 SYNTHESIS OF SUBSTRATES IN N-GLYCAN BIOSYTHESIS%REACTOME%R-HSA-446219.2 Synthesis of substrates in N-glycan biosythesis ST3GAL3 ST6GALNAC1 CMAS MPI GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 ST6GALNAC2 GFUS NANS NUDT14 ST6GAL2 ALG5 RENBP DPM1 DPM2 DPM3 MVD ST6GALNAC5 GNE ST3GAL4 ST6GALNAC6 UAP1 NPL ST3GAL1 FUOM ST3GAL2 ST6GAL1 NEU2 NEU3 NEU4 GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 ST3GAL6 ST6GALNAC3 CTSA ST6GALNAC4 PMM1 ST8SIA1 ST8SIA2 GFPT2 GFPT1 PMM2 ST8SIA3 SRD5A3 DOLK NUS1 NAGK DHDDS FCSK GLB1 DOLPP1 SLC35A1 SLC35C1 SLC17A5 SIGNALING BY NON-RECEPTOR TYROSINE KINASES%REACTOME DATABASE ID RELEASE 76%9006927 Signaling by Non-Receptor Tyrosine Kinases CCNE1 NR3C1 DOCK1 CDK2 ELMO2 ARHGAP35 ERBB2 SFPQ CBL LRRK2 PELP1 NRG1 NRG2 NRG3 NRG4 ELMO1 CRK KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN EGF HIF1A SOCS3 GPNMB STAP2 PTPN1 SRMS UBA52 HBEGF BCAR1 STAT3 EGFR AKT1 UBB HRAS UBC RASA1 CCND1 RPS27A CDK4 NRAS DOK1 PTK6 RAC1 ARAP1 EREG RHOA BTC CDKN1B AKT-MEDIATED INACTIVATION OF FOXO1A%REACTOME%R-HSA-211163.2 AKT-mediated inactivation of FOXO1A FOXO1 AKT2 AKT1 AKT3 DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME DATABASE ID RELEASE 76%5619037 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 PURINE SALVAGE%REACTOME%R-HSA-74217.4 Purine salvage HPRT1 ADA GMPR2 ADK GMPR AMPD1 AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP PROLACTIN RECEPTOR SIGNALING%REACTOME%R-HSA-1170546.1 Prolactin receptor signaling STAT5A STAT5B CSH1 PRL PRLR GHR GH1 PTPN11 RBX1 JAK2 BTRC SKP1 CUL1 ASSEMBLY OF COLLAGEN FIBRILS AND OTHER MULTIMERIC STRUCTURES%REACTOME DATABASE ID RELEASE 76%2022090 Assembly of collagen fibrils and other multimeric structures COL5A3 COL7A1 COL6A2 COL4A3 COL5A2 COL6A1 COL8A2 COL4A5 BMP1 COL8A1 COL9A1 COL6A3 COL9A3 COL6A6 COL9A2 COL18A1 COL6A5 LAMC2 CTSS MMP20 CTSL CTSB MMP7 MMP3 MMP9 MMP13 COL15A1 LAMA3 LAMB3 TLL2 TLL1 ITGB4 LOXL3 LOXL4 LOXL1 LOXL2 PCOLCE LOX PXDN ITGA6 COL11A1 PLEC COL11A2 COL10A1 CD151 COL27A1 COL24A1 COL1A1 COL3A1 COL2A1 COL1A2 COL5A1 COL4A2 COL4A1 COL4A4 TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX%REACTOME%R-HSA-445989.3 TAK1 activates NFkB by phosphorylation and activation of IKKs complex TAB1 SAA1 UBE2V1 HMGB1 APP IKBKB CHUK NFKBIA RELA IKBKG NFKB2 NOD1 NOD2 AGER IRAK1 IRAK2 S100A12 NFKB1 NKIRAS1 RIPK2 NKIRAS2 S100B TRAF6 UBE2N NFKBIB TAB3 MAP3K7 TAB2 PLASMA LIPOPROTEIN ASSEMBLY%REACTOME DATABASE ID RELEASE 76%8963898 Plasma lipoprotein assembly APOA1 APOA4 APOC2 APOC1 P4HB APOB A2M PRKACG PRKACB SAR1B MTTP ZDHHC8 PRKACA APOE ABCA1 APOC4 APOC3 APOA2 EVENTS ASSOCIATED WITH PHAGOCYTOLYTIC ACTIVITY OF PMN CELLS%REACTOME DATABASE ID RELEASE 76%8941413 Events associated with phagocytolytic activity of PMN cells LPO MPO DEFECTIVE DPM3 CAUSES DPM3-CDG (CDG-1O)%REACTOME DATABASE ID RELEASE 76%4719360 Defective DPM3 causes DPM3-CDG (CDG-1o) DPM1 DPM2 DPM3 INTERACTIONS OF TAT WITH HOST CELLULAR PROTEINS%REACTOME%R-HSA-176034.2 Interactions of Tat with host cellular proteins CDK9 CCNT1 tat NS1 MEDIATED EFFECTS ON HOST PATHWAYS%REACTOME DATABASE ID RELEASE 76%168276 NS1 Mediated Effects on Host Pathways PABPN1 KPNA7 NUP42 KPNA4 NUP210 NUP43 KPNA5 KPNA2 RAE1 KPNA3 RANBP2 NUP93 CPSF4 EIF2AK2 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 KPNA1 NUP214 NUP153 NS KPNB1 SEC13 NUP62 NDC1 ISG15 NUP133 NUP107 NUP188 NUP50 NUP54 THROMBOXANE SIGNALLING THROUGH TP RECEPTOR%REACTOME DATABASE ID RELEASE 76%428930 Thromboxane signalling through TP receptor GNG12 GNG11 GNG13 GNA14 GNB2 GNAQ GNB1 GNG3 GNA15 GNB4 GNG2 GNB3 GNA13 GNG5 AAMP GNG4 GNB5 GNG7 GNA11 GNG8 GNGT1 TBXA2R GNGT2 GNG10 MPS IV - MORQUIO SYNDROME B%REACTOME DATABASE ID RELEASE 76%2206308 MPS IV - Morquio syndrome B GLB1 DEFECTIVE ABCC2 CAUSES DJS%REACTOME%R-HSA-5679001.3 Defective ABCC2 causes DJS ABCC2 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF GROWTH FACTORS AND THEIR RECEPTORS%REACTOME DATABASE ID RELEASE 76%8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors ESR1 ERBB2 TGFA VEGFA CGA TFAP2A TFAP2B TFAP2C CGB8 ATAD2 YY1 KIT EGFR ERK MAPK TARGETS%REACTOME%R-HSA-198753.1 ERK MAPK targets DUSP6 PPP2CA DUSP7 PPP2CB MAPK7 PPP2R1B PPP2R5D PPP2R1A MEF2A MAPK14 MEF2C MAPK11 ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DUSP4 DUSP3 VRK3 DEFECTS OF FORMATION OF FIBRIN CLOT (CLOTTING CASCADE)%REACTOME DATABASE ID RELEASE 76%9651496 Defects of Formation of Fibrin Clot (Clotting Cascade) F2 F10 F8 VWF GP1BB KLKB1 F12 F11 GP1BA GP5 GP9 F9 SERPING1 GGCX TPST2 TPST1 NTF3 ACTIVATES NTRK3 SIGNALING%REACTOME DATABASE ID RELEASE 76%9034013 NTF3 activates NTRK3 signaling NTRK3 NTF3 LGI-ADAM INTERACTIONS%REACTOME%R-HSA-5682910.2 LGI-ADAM interactions LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 STX1B CACNG8 ADAM23 CACNG2 CACNG3 STX1A CACNG4 DLG4 DEFECTIVE CYP11B1 CAUSES AH4%REACTOME%R-HSA-5579017.2 Defective CYP11B1 causes AH4 CYP11B1 RESPONSE OF EIF2AK1 (HRI) TO HEME DEFICIENCY%REACTOME DATABASE ID RELEASE 76%9648895 Response of EIF2AK1 (HRI) to heme deficiency PPP1R15A CEBPB ASNS EIF2AK1 CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 GRB10 TRIB3 CHAC1 ATF5 ATF3 ATF4 MITOTIC G2-G2 M PHASES%REACTOME%R-HSA-453274.2 Mitotic G2-G2 M phases PPP2R1B PPP2CA PPP2CB HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PPP1CB PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 PPP2R2A OFD1 PPME1 PPP1R12A PHLDA1 CEP135 HSP90AB1 GTSE1 BORA FKBPL FBXW11 CDC25C TUBB CEP131 CDC25B TUBGCP2 HAUS4 HMMR HAUS3 CSNK1D PKMYT1 TPX2 HAUS6 TUBGCP5 HAUS5 CSNK1E TUBGCP6 TUBGCP3 TUBG1 TUBGCP4 DYNLL1 FBXL7 CKAP5 LIN54 HAUS2 TUBA4A FOXM1 MYBL2 HAUS1 AKAP9 LIN52 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 UBA52 NME7 AJUBA LIN37 OPTN LIN9 SDCCAG8 LCMT1 PAFAH1B1 CDK11A DYNC1I2 FBXL18 DCTN2 PPP2R3B SSNA1 CDK11B XPO1 DCTN3 MZT1 CUL1 CENPF AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 E2F1 CLASP1 CEP78 E2F3 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CDKN1A CEP43 CCNA2 CCNA1 TP53 CDK2 RBX1 WEE1 CCNH EP300 CDK7 MNAT1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 REGULATION OF RUNX1 EXPRESSION AND ACTIVITY%REACTOME%R-HSA-8934593.1 Regulation of RUNX1 Expression and Activity CBFB CCND3 RUNX1 CDK6 CCND2 CCND1 PTPN11 TNRC6C MOV10 TNRC6A AGO3 TNRC6B AGO4 AGO1 AGO2 SRC PML CARGO TRAFFICKING TO THE PERICILIARY MEMBRANE%REACTOME DATABASE ID RELEASE 76%5620920 Cargo trafficking to the periciliary membrane SMO RAB3IP RHO ARF4 SSTR3 CCT3 RAB8A EXOC8 EXOC7 TCP1 EXOC4 GBF1 EXOC3 RAB11A EXOC6 EXOC5 CCT2 EXOC2 EXOC1 CCT8 CCT5 CCT4 PKD2 PKD1 CNGA2 BBS9 CNGA4 BBS7 BBS5 BBS4 MKKS CYS1 LZTFL1 BBS10 MCHR1 RP2 BBS12 CNGB1 UNC119B ARL6 ARL3 ASAP1 ARL13B INPP5E PDE6D NPHP3 RAB11FIP3 BBS2 BBS1 BBIP1 TTC8 CIRCADIAN CLOCK%REACTOME%R-HSA-400253.3 Circadian Clock RBM4 HDAC3 CREBBP DBP RORA NAMPT NR3C1 SIRT1 KLF15 CRY2 CRY1 SIK1 CLOCK ARNTL2 NPAS2 ARNTL RXRA RAI1 AVP NFIL3 NOCT NRIP1 MEF2D PPARGC1A PPARA NR1D1 PER2 PER1 BHLHE40 MEF2C EP300 PPP1CB FBXL3 BTRC SKP1 CSNK1D CSNK1E HIF1A F7 UBA52 CUL1 UBB NCOA1 MED1 SREBF1 NCOA2 UBC CPT1A SMARCD3 CHD9 RPS27A NCOA6 HELZ2 PPP1CC TBL1XR1 TGS1 CARM1 TBL1X CREB1 NCOR1 PPP1CA ATF2 CRTC2 CRTC3 CRTC1 SERPINE1 BHLHE41 FORMYL PEPTIDE RECEPTORS BIND FORMYL PEPTIDES AND MANY OTHER LIGANDS%REACTOME%R-HSA-444473.1 Formyl peptide receptors bind formyl peptides and many other ligands HEBP1 SAA1 APP ANXA1 FPR1 FPR3 MT-RNR2 FPR2 UNC93B1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 76%5602415 UNC93B1 deficiency - HSE UNC93B1 TLR3 PLCG1 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1251932.3 PLCG1 events in ERBB2 signaling ERBB2 EGFR PLCG1 EGF INTESTINAL ABSORPTION%REACTOME%R-HSA-8963676.2 Intestinal absorption SLC5A1 SLC2A5 SLC2A2 RSC1A1 DEATH RECEPTOR SIGNALLING%REACTOME%R-HSA-73887.4 Death Receptor Signalling TAB1 HDAC3 PRDM4 NGF TNFRSF1A CASP8 GNA13 TRADD RIPK1 TRAF2 FADD TRIO ARHGDIA MCF2L VAV3 ARHGEF16 VAV1 ARHGEF5 ARHGEF26 PREX1 KALRN YWHAE VAV2 TIAM1 NFKB1 MAPK8 ABR ARHGEF7 UBA52 MCF2 TNFSF10 TNFRSF10B TNFRSF10A CFLAR UBB TNFRSF10D PLEKHG5 UBC RPS27A RAC1 ADAM17 ITSN1 PSEN1 BCL2L11 NCSTN SOS1 RASGRF2 SPPL2B SPPL2A TNF CASP3 ARHGEF40 UL36 PRKCI USP4 USP2 OMG CLIP3 TIAM2 MAG OBSCN RBCK1 SQSTM1 NGEF NSMAF BEX3 MAGED1 TNFAIP3 PSEN2 RTN4 APH1A BAG4 APH1B SHARPIN ECT2 CRMA ARHGEF33 ARHGEF35 CYLD ARHGEF37 ARHGEF39 ARHGEF38 NET1 TAX1BP1 SPI-2 OTUD7B ARHGEF10L AATF SMPD3 SMPD2 AKAP13 RACK1 CASP2 HDAC2 MYD88 PSENEN HDAC1 ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 FASLG ARHGEF15 ARHGEF17 ARHGEF19 FAS TRAF1 SORCS3 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 BIRC2 ITGB3BP BIRC3 ARHGEF6 RNF31 XIAP FGD1 FGD2 FGD3 FGD4 LINGO1 USP21 BAD OTULIN IKBKB CHUK NFKBIA CASP10 RELA IKBKG ARHGEF18 IRAK1 RIPK2 RHOA TRAF6 TAB3 MAP3K7 NGFR TAB2 PROCESSING OF SMDT1%REACTOME%R-HSA-8949664.1 Processing of SMDT1 STOML2 MCUB SPG7 PHB MAIP1 PHB2 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU REGULATION OF TP53 ACTIVITY%REACTOME%R-HSA-5633007.3 Regulation of TP53 Activity RHNO1 L3MBTL1 BLM PPP2R1B MEAF6 MAPKAP1 BRIP1 NUAK1 SMYD2 TP53BP2 ATRIP BANP MAP2K6 BARD1 PLK3 BRPF1 BRPF3 JMY CSNK2A1 RAD17 PPP2R5C RAD9B TP73 CSNK2A2 ATR RAD9A PRR5 DYRK2 CSNK2B PPP1R13B SETD9 BRCA1 ING5 ING2 PIP4P1 EXO1 PPP1R13L TOPBP1 PPP2CA RFC5 PPP2CB PRMT5 RMI2 BRD1 RFC3 RFC4 PRKAB2 RFC2 RMI1 PRKAA2 PRKAG1 PDPK1 TOP3A PRKAG2 SGK1 RNF34 PRKAB1 WRN PRKAG3 TP53INP1 RBBP8 PPP2R1A RICTOR RFFL BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 RAD50 TTC5 RPA3 CCNG1 RAD1 CDK5R1 TPX2 CDK5 UBA52 AKT1 AURKA PML UBB UBC RPS27A AURKB DAXX HIPK2 MAPK14 MAPK11 CDK1 PHF20 CHEK2 ZNF385A AKT3 CCNA2 CCNA1 TP53 CDKN2A CDK2 MDM2 ATM MDM4 SUPT16H TAF9 SSRP1 TAF1L TAF7L TAF9B TAF15 TAF12 TAF13 TAF10 TAF11 TAF7 TAF4B EHMT2 TAF6 USP2 TAF5 TAF4 CHD4 TAF3 CHD3 TAF2 TAF1 EP300 TBP CHEK1 PIN1 HDAC2 HDAC1 RBBP4 RBBP7 MTA2 MBD3 PRKAA1 STK11 AKT2 MLST8 GATAD2B GATAD2A MTOR USP7 MRE11 TP53RK EHMT1 PRDM1 NOC2L KAT5 PIP4K2A PIP4K2B NBN KMT5A PIP4K2C TP63 HUS1 KAT6A MAPKAPK5 DNA2 ACTIVATION OF TRKA RECEPTORS%REACTOME%R-HSA-187015.2 Activation of TRKA receptors ADCYAP1 ADCYAP1R1 NGF ADORA2A NTRK1 NTRK2 OXYGEN-DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA-INDUCIBLE FACTOR ALPHA%REACTOME DATABASE ID RELEASE 76%1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ELOB ELOC RBX1 UBE2D2 UBE2D3 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 HIF3A PSMD4 LIMD1 PSMD5 CUL2 PSMD2 VHL PSMD3 EGLN1 PSMD1 EGLN3 PSMA5 EGLN2 PSMA6 WTIP PSMA3 EPAS1 PSMA4 PSMA1 HIF1A PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 AJUBA PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EPIGENETIC REGULATION OF GENE EXPRESSION%REACTOME DATABASE ID RELEASE 76%212165 Epigenetic regulation of gene expression TDG ARID4B RRP8 SAP130 SAP30BP SAP30 DNMT1 BAZ2A GSK3B SUDS3 PHF19 EZH2 SUV39H1 PHF1 DNMT3L SIN3B DNMT3B JARID2 EED TET2 TET1 AEBP2 MTF2 TET3 UHRF1 SAP30L SAP18 SUZ12 MBD2 SIN3A UBTF SIRT1 CCNH POLR2E POLR2F POLR2H H2AX EHMT2 H2AB1 POLR2K H2AC19 POLR2L CHD4 CHD3 GTF2H1 TTF1 GTF2H2 ACTB H2AC14 H2BC21 GTF2H3 EP300 GTF2H4 H2BU1 H3-3B GTF2H5 CDK7 H3C8 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 BAZ1B H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 DDX21 TAF1D H3C15 MTA1 TAF1B RBBP4 TAF1C TAF1A H2BS1 RBBP7 MTA2 SF3B1 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 SMARCA5 H2BC1 DEK GATAD2B GATAD2A MYBBP1A H2AC20 ERCC6 NEURODEGENERATIVE DISEASES%REACTOME%R-HSA-8863678.1 Neurodegenerative Diseases FOXO3 CDC25C GOLGA2 BCL2L11 CDC25B JUN CAPNS1 SOD2 FASLG LMNB1 CAPNS2 YWHAE PRDX2 PRDX1 CAPN2 CAPN1 CAST CDK5 APP CDC25A CDK5R1 HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME DATABASE ID RELEASE 76%5693579 Homologous DNA Pairing and Strand Exchange RHNO1 BLM BRIP1 ATRIP ATM BARD1 RAD17 RAD9B ATR RAD9A BRCA1 EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 RMI1 BRCA2 TOP3A RAD51AP1 XRCC2 WRN XRCC3 PALB2 RBBP8 RAD51D MRE11 RAD51 RPA1 CHEK1 RPA2 KAT5 NBN RAD50 RPA3 RAD51B HUS1 RAD1 RAD51C DNA2 DEFECTIVE SLC22A18 CAUSES LUNG CANCER (LNCR) AND EMBRYONAL RHABDOMYOSARCOMA 1 (RMSE1)%REACTOME%R-HSA-5619066.1 Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1) SLC22A18 TRANSCRIPTIONAL REGULATION BY TP53%REACTOME%R-HSA-3700989.6 Transcriptional Regulation by TP53 CREBBP TXNRD1 YWHAE PPP2R1A YWHAG CDC25C TPX2 CDK5 UBA52 AURKA PML CCNB1 UBB TFDP1 UBC TFDP2 RPS27A E2F1 CENPJ CDK1 ATF2 CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 TAF9 SSRP1 CDK9 TAF1L CCNH TAF7L POLR2A TAF9B POLR2B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 TAF4B POLR2I EHMT2 POLR2J TAF6 USP2 POLR2K TAF5 POLR2L TAF4 CHD4 TAF3 GTF2H1 CHD3 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 EP300 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 CHEK1 PIN1 CASP2 HDAC2 HDAC1 RBBP4 RBBP7 MTA2 MBD3 GATAD2B GATAD2A CASP10 USP7 CARM1 MRE11 TP53RK EHMT1 PRDM1 NOC2L KAT5 PIP4K2A PIP4K2B NBN KMT5A PIP4K2C TCEA1 TP63 HUS1 KAT6A MAPKAPK5 DNA2 RHNO1 L3MBTL1 BLM PPP2R1B MEAF6 MAPKAP1 BRIP1 NUAK1 SMYD2 TP53BP2 ATRIP BANP MAP2K6 BARD1 PLK3 BRPF1 BRPF3 JMY GPX2 CSNK2A1 RAD17 PPP2R5C RAD9B TP73 CSNK2A2 ATR RAD9A PRR5 DYRK2 CSNK2B PPP1R13B SETD9 YWHAQ BRCA1 ING5 ING2 YWHAH PIP4P1 EXO1 PPP1R13L PPP2CA TOPBP1 PPP2CB RFC5 PRMT5 RMI2 BRD1 RFC3 RFC4 PRKAB2 RFC2 RMI1 PRKAA2 PRKAG1 PDPK1 TOP3A PRKAG2 SGK1 RNF34 PRKAB1 WRN PRKAG3 TP53INP1 RBBP8 RICTOR RFFL BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 RAD50 TTC5 RPA3 CCNG1 RAD1 CDK5R1 GLS YWHAB AKT1 TNFRSF10B TNFRSF10A TNFRSF10D YWHAZ JUN PRDX2 PRDX1 AURKB DAXX HIPK2 TNRC6C MOV10 RAD51D MDC1 CCNK TNRC6A MT-CO1 TNRC6B TP53AIP1 COX7A2L MAPK14 SCO1 MAPK11 SCO2 DDIT4 MT-CO2 MT-CO3 CDKN1A TXN CDKN1B PRELID3A PHF20 CHEK2 PRELID1 SURF1 ZNF385A AKT3 CRADD CCNA2 GADD45A CCNA1 PLK2 CCNE2 CDK12 CCNE1 TP53 CDK13 GPI PCBP4 BTG2 COX7B CDKN2A COX7C CDK2 BBC3 MDM2 ATM AIFM2 TNKS1BP1 MDM4 COX8A CNOT6L PRMT1 FOS DDB2 PCNA COX5B COX5A AGO3 PLAGL1 PERP AGO4 PMS2 AGO1 BID AGO2 TIGAR NPM1 MLH1 SFN COX6C LRPPRC STEAP3 CCNT2 TACO1 COX6A1 SESN3 SESN2 BNIP3L G6PD IGFBP3 COX6B1 MSH2 FANCD2 COX19 COX16 COX18 NDRG1 PMAIP1 COX11 COX14 BCL2L14 ZNF420 FANCI TNFRSF10C CHM CNOT10 FANCC CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 CNOT2 CNOT3 CYCS CNOT8 CNOT9 COX20 COX4I1 PTEN TRIAP1 PIDD1 CASP6 CASP1 FAS APAF1 RABGGTB RABGGTA RBL2 RBL1 RRM2B TMEM219 BIRC5 NLRC4 E2F4 PRKAA1 E2F7 E2F8 NDUFA4 RPTOR ARID3A STK11 BAX AKT2 MLST8 SLC38A9 TSC2 TSC1 MTOR RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 GLS2 LEISHMANIA INFECTION%REACTOME%R-HSA-9658195.2 Leishmania infection GSDMD V1-20 GPR15 IGKV2D-40 IGHV3-11 FZD7 IGHV3-13 GPR27 GPR25 GPR20 RLN2 IGHV1-46 RLN3 ADM PTH1R IGHV IL10 LPG1G2 CYFIP1 V5-4 NCKAP1 V5-1 SYK ARPC4 GPR32 IL18 PTH2R ARPC5 FYN V5-6 HCK MAPK1 IL1A IL1B BRK1 IGLV3-19 RAMP2 ARPC2 RAMP3 ARPC3 MAPK3 GPR45 PTH GNAI3 WAS PRKX GNAI1 GNAI2 IGLV3-25 NT5E INSL3 IGLV3-27 IGKC IGLV3-21 TSHB GPR150 PTGIR V4-6 V4-2 V4-1 AVPR2 IGKV1-5 SCTR CYBA ACTR2 MYO9B GCG GHRH VAV2 ADM2 RAMP1 IGLV PRKACA IGHG3 PYCARD IGHG4 ADORA2A IGHG1 ADORA2B IGHG2 GGT1 NOXO1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 DPEP2 DPEP1 IAPP DPEP3 ABL1 GNAZ CALCA CALCB CALCRL IGHV4-59 NCKAP1L GPR83 GPR84 WASF1 IGLV2-11 NCKIPSD WASF2 CALCR IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 DVL1 IGLV1-44 TSHR MYO1C IGKV3-15 BAIAP2 DVL3 NLRP3 IGKV3-11 POMC V2-8 ABI2 GGT5 CD163 ABI1 IGLV7-43 IGKV1D-16 NOXA1 IGKV1D-12 IL6 NOX1 IGLV1-51 IGLV2-23 IGKV3-20 GLP1R PRKAR2B IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A PSTPIP1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 RHBDF2 GLP2R IGKV3D-20 GIP MYH2 CRH ADAM17 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 PTH2 PTHLH IGKV1-39 IGKV1-33 FCGR1A WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 FCGR2A SUGT1 VIP MYO5A CTSG ACTB CD3G FURIN WNT5A FGR VAV3 HTR4 VAV1 RXFP1 ITPR1 RXFP2 GNG10 ELMO2 ITPR2 ITPR3 HTR6 HTR7 GNG12 C3AR1 GNG11 GNG13 GNB2 PTGDR GNB1 TAAR8 GNB4 TAAR9 TAAR6 GNB3 TAAR5 MYH9 TAAR2 GNB5 P2RX7 TAAR1 WASL GNGT1 P2RX4 GNGT2 CDC42 LHB NFKB1 CALM1 MAPK8 HSP90AB1 NCK1 C3 ADCYAP1 ADCYAP1R1 MC2R GNG3 GNG2 CGA GNG5 GNG4 GNG7 GNG8 MC1R ARPC1B ACTG1 LYN YES1 PTK2 JUN MC4R CREB1 MAPK14 GPR39 TXN FSHB PLK2 GPBAR1 MC3R ADRB3 PLCG1 PRKACG FSHR PRKACB AVP PTGER4 NPSR1 ADCY9 PRKAR1B PRKAR1A BTK PRKAR2A PTGER2 GNAS NPS ADCY4 ADCY3 ADCY2 ADCY1 GPHA2 ARPC1A ADCY8 ADCY7 ADCY6 ADCY5 P2RY11 MC5R ELMO1 CRK GPHB5 CASP1 CYSLTR1 CYSLTR2 CYFIP2 VIPR1 VIPR2 LHCGR AHCYL1 SCT WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 GPR176 IGKV1-16 GNAT3 IGKV1-17 IGKV1-12 ADRB1 IGHV3-7 RELA ADRB2 IGHV3-9 ENTPD1 NFKB2 IGHV3-30 V2-17 IGHV3-33 ENTPD5 V2-15 TAAR3P V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 TXNIP HRH2 V1-11 IGKV2D-30 GIPR V1-16 DRD1 V1-13 IGHV1-69 MEFV CRHR1 CRHR2 DVL2 DRD5 GHRHR PLCG2 HMOX1 SORAFENIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702624.1 sorafenib-resistant FLT3 mutants FLT3 THE ROLE OF NEF IN HIV-1 REPLICATION AND DISEASE PATHOGENESIS%REACTOME%R-HSA-164952.1 The role of Nef in HIV-1 replication and disease pathogenesis AP1S2 AP1M2 AP1S1 AP1M1 AP1S3 DOCK2 ELMO1 nef B2M HLA-A CD8B LCK PACS1 CD28 FYN AP2S1 ATP6V1H HCK CD4 AP2B1 PAK2 AP1G1 ARF1 AP2A1 RAC1 AP1B1 AP2A2 AP2M1 ACTIVATION OF RAC1 DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619229.2 Activation of RAC1 downstream of NMDARs RAC1 CAMK1 CAMKK1 CAMKK2 CALM1 GIT1 ACTIVATION OF NMDA RECEPTORS AND POSTSYNAPTIC EVENTS%REACTOME%R-HSA-442755.7 Activation of NMDA receptors and postsynaptic events KPNA2 PRKACG PRKACB CAMK1 ACTN2 PRKAR1B CAMKK1 RASGRF2 CAMKK2 RASGRF1 KIF17 PRKAR1A NRGN GRIN2B RPS6KA6 MAPK1 GRIN1 RPS6KA3 CASK GRIN2D GRIA2 DLG1 RPS6KA2 LIN7A PRKAR2A DLG2 RPS6KA1 LIN7C DLG3 LRRC7 PPM1E MAPK3 LIN7B DLG4 NEFL PPM1F GRIN2A GRIA3 PRKX GRIA4 GRIN2C GRIN3B GRIN3A NBEA APBA1 PRKAB2 PRKAA2 PRKAG1 PDPK1 PRKAG2 PRKAB1 PRKAG3 ADCY1 ADCY8 PRKACA CALM1 GIT1 NRG1 PRKAA1 CAMK2B PRKAR2B HRAS CAMK2D CAMK2A CAMK2G NRAS CREB1 RAC1 CAMK4 GRIA1 SRC REGULATION OF PTEN STABILITY AND ACTIVITY%REACTOME%R-HSA-8948751.1 Regulation of PTEN stability and activity CSNK2A1 CSNK2A2 TRIM27 CSNK2B PREX2 USP13 WWP2 RNF146 NEDD4 MKRN1 STUB1 FRK OTUD3 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PTEN PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 XIAP PSMD13 AKT2 PSMA7 PSMB10 PSMA8 AKT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TNKS2 TNKS AKT3 ACETYLCHOLINE INHIBITS CONTRACTION OF OUTER HAIR CELLS%REACTOME%R-HSA-9667769.1 Acetylcholine inhibits contraction of outer hair cells CHRNA9 CHRNA10 KCNN2 KCNMB1 KCNMA1 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 76%5659735 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 CYCLIN A B1 B2 ASSOCIATED EVENTS DURING G2 M TRANSITION%REACTOME DATABASE ID RELEASE 76%69273 Cyclin A B1 B2 associated events during G2 M transition CCNA1 CDC25C CDC25B PPP2R1B PKMYT1 CDK2 FOXM1 WEE1 CCNH LCMT1 PPP2R3B XPO1 CCNB2 CCNB1 PPP2CA PPP2CB CDK7 MNAT1 PPP2R1A PLK1 CDC25A CDK1 PPP2R2A PPME1 CCNA2 SIALIC ACID METABOLISM%REACTOME%R-HSA-4085001.2 Sialic acid metabolism SLC35A1 ST3GAL3 ST6GALNAC1 CMAS NANP ST6GALNAC2 NANS ST6GAL2 ST6GALNAC5 ST3GAL4 GNE ST6GALNAC6 NPL ST3GAL1 ST3GAL2 NEU2 ST6GAL1 NEU3 NEU4 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 ST3GAL6 CTSA ST6GALNAC3 ST6GALNAC4 ST8SIA1 ST8SIA2 SLC17A5 ST8SIA3 GLB1 PENTOSE PHOSPHATE PATHWAY%REACTOME DATABASE ID RELEASE 76%71336 Pentose phosphate pathway RBKS G6PD PRPS2 PRPS1 RPEL1 RPE TALDO1 PGD DERA RPIA SHPK PGM2 PGLS TKT PRPS1L1 MPS IIIB - SANFILIPPO SYNDROME B%REACTOME%R-HSA-2206282.2 MPS IIIB - Sanfilippo syndrome B NAGLU FERTILIZATION%REACTOME%R-HSA-1187000.2 Fertilization CATSPER1 CATSPER3 CATSPER2 CATSPER4 HVCN1 ADAM21 ADAM20 OVGP1 IZUMO3 IZUMO2 IZUMO4 IZUMO1 ADAM30 ADAM2 ACR KCNU1 CATSPERB CATSPERD CATSPERG CD9 ZP1 ZP3 ZP2 SPAM1 ZP4 B4GALT1 DEFECTIVE F8 BINDING TO VON WILLEBRAND FACTOR%REACTOME DATABASE ID RELEASE 76%9672393 Defective F8 binding to von Willebrand factor F8 VWF TRANSCRIPTION OF SARS-COV-1 SGRNAS%REACTOME DATABASE ID RELEASE 76%9682708 Transcription of SARS-CoV-1 sgRNAs N 1a rep TRAF3 DEFICIENCY - HSE%REACTOME%R-HSA-5602571.2 TRAF3 deficiency - HSE TRAF3 TICAM1 TLR3 OVARIAN TUMOR DOMAIN PROTEASES%REACTOME DATABASE ID RELEASE 76%5689896 Ovarian tumor domain proteases TP53 PTEN ESR1 VCP RIPK1 UBA52 OTUB2 OTUD7A VCPIP1 ZRANB1 IFIH1 UBB YOD1 APC RNF135 RNF128 OTUD5 MAVS TNIP1 UBC TNIP2 DDX58 TNIP3 OTUB1 TRIM25 RPS27A IKBKG TNFAIP3 OTUD3 UBE2D1 NOD1 NOD2 TRAF3 CDK1 OTUD7B RIPK2 RHOA TRAF6 DEFECTIVE SLC2A9 CAUSES HYPOURICEMIA RENAL 2 (RHUC2)%REACTOME%R-HSA-5619047.2 Defective SLC2A9 causes hypouricemia renal 2 (RHUC2) SLC2A9 SHC1 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 76%1250196 SHC1 events in ERBB2 signaling PRKCD PRKCA NRG1 NRG2 NRG3 HRAS NRG4 ERBB2 SHC1 PRKCE PTPN12 SOS1 EGF NRAS HBEGF EGFR EREG BTC RAP1 SIGNALLING%REACTOME DATABASE ID RELEASE 76%392517 Rap1 signalling YWHAZ RAP1GAP2 RASGRP2 RASGRP1 PRKACG RAP1GAP PRKACB RAP1B RAP1A RAF1 SIPA1 RAPGEF3 RAPGEF4 PRKACA YWHAB TRNA PROCESSING IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 76%6784531 tRNA processing in the nucleus RPP21 RPP25 TSEN34 DDX1 CSTF2 RPP14 NUP42 C2orf49 NUP43 RTRAF RAE1 CPSF1 RANBP2 RPP40 CPSF4 XPOT FAM98B RAN NUP35 NUP37 SEC13 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP214 NUP153 ELAC2 TRNT1 NUP62 NDC1 POP5 POP7 NUP133 POP1 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 NUP50 TSEN54 NUP54 CLP1 RPP38 NF-KB IS ACTIVATED AND SIGNALS SURVIVAL%REACTOME DATABASE ID RELEASE 76%209560 NF-kB is activated and signals survival UBB NGF IKBKB UBC NFKBIA SQSTM1 RELA RPS27A UBA52 IRAK1 NFKB1 TRAF6 NGFR TRANSPORT OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 76%382551 Transport of small molecules SLC3A2 RUNX1 SLC36A4 ATP6V1H SLC24A2 SLC24A1 SLC24A4 SLC24A3 SLC8B1 PRKACA SKP1 UBA52 CUL1 UBB PRKAR2B HBB UBC RPS27A NR1H2 AKAP1 SLC6A20 HDLBP PCSK9 CLTA AP2A1 ZDHHC8 VLDLR PCSK6 AP2A2 LIPA PCSK5 LIPC CREB3L3 LIPG LDLRAP1 SLC4A1 AP2M1 ABCA12 CUBN SLC4A4 MYLIP PSMD8 AMN SLC12A6 PSMD9 SLC39A4 APOA2 PSMD6 APOA1 SLC34A3 PSMD7 APOA4 ABCG8 PSMD4 SLC34A2 LSR APOA5 ABCG5 PSMD5 SLC6A19 SOAT1 PSMD2 NPC1 SLC6A18 PSMD3 SOAT2 PSMD1 NPC2 SLC6A14 PSMA5 ANGPTL8 SLC11A2 PSMA6 ANGPTL3 SLC5A7 ANGPTL4 PSMA3 LPA VCP PSMA4 CES3 PSMA1 ABCG1 ABCB6 PSMA2 CETP PSME3 SAR1B ABCB4 PSME4 MTTP SEL1L PSME1 SLC1A1 LPL PSME2 SLC1A3 LCAT SLC5A1 LMF2 PSMD10 LMF1 PSMB11 SLC5A2 APOF PSMD12 AP2S1 PSMD11 APOE PSMD14 LDLR PSMD13 FGF21 GPIHBP1 PSMA7 ABCA1 PSMB10 PSMA8 MBTPS1 ABCA3 PSMB6 APOC4 ERLIN1 PSMB7 APOC3 PSMB4 NR1H3 ERLIN2 PSMB5 APOBR CP PSMB2 AP2B1 PSMB3 NCEH1 SLC2A9 SLC6A5 PSMB1 APOC2 PSMF1 SLC26A4 APOC1 ALB SLC26A3 PSMB8 RNF185 P4HB PSMB9 MBTPS2 SEM1 SLC2A1 PSMC5 SLC40A1 PSMC6 SLC22A4 SLC2A2 SLC6A2 PSMC3 SLC22A3 SLC6A3 PSMC4 RSC1A1 PSMC1 SLC22A15 PSMC2 SLC22A5 SLC22A12 SLC22A16 HEPH SLC22A18 RAF1 SLC22A2 ABCD1 SLC22A1 ABCC2 SLC36A2 SLC2A10 ABCC6 ABCC9 SLC7A7 SLC7A9 SLC20A2 DERL3 DERL1 DERL2 SLC3A1 RNF5 ERLEC1 OS9 SLC12A3 SLC16A1 KCNJ11 SLC4A2 SLC12A1 SLC4A3 SLC4A5 ABCA10 RHAG SLC5A9 TFR2 ABCB1 TTYH3 TTYH2 ABCB7 ABCB5 CLCNKB NEDD4L CLCNKA TUSC3 ABCB8 ARL2 ABCB9 GNG10 MAGT1 SLC30A10 SLC5A3 SLC5A4 CYB5R2 CYB5R1 GNG12 CYB5R4 GNG11 HMOX2 GNG13 ABCA2 ABCA5 LETM1 GNB2 ABCA6 ABCA4 GNB1 ABCA9 ABCA7 GNB4 SLC16A10 ABCA8 GNB3 SLC6A6 FXYD4 SLC6A9 GNB5 FXYD3 FBXL5 FXYD2 FXYD1 FXYD7 GNGT1 CYB5RL FXYD6 SLC35B3 SLC6A1 SLC35B2 GNGT2 ABCC10 LCN9 ABCC11 SLC27A1 EMB SLC35B4 SLC18A1 SLC35D1 SLC18A2 SLC35D2 SLC2A14 SLCO1B1 SLC2A11 LCN15 SLC2A13 SLCO2B1 SLC2A12 LCN12 NIPA1 SLCO1B3 SLC39A10 APOD NIPA2 SLC16A2 SLC39A14 SLC35A2 SLC7A6 SLC35A1 SLC7A8 SLC35A3 SLC7A1 SLC35C1 SLC7A3 SLC33A1 ANO10 SLCO1C1 ARL2BP RHBG GNG3 SLCO4A1 SLC17A3 DMTN SLCO4C1 WWP1 SLCO2A1 GNG2 ABCB10 SLCO1A2 OSTM1 LCN1 GNG5 ATP8A2 SLC27A6 GNG4 SLC29A4 ATP8A1 GNG7 BEST2 SLC25A5 SLC29A1 ATP12A GNG8 SLC28A2 SLC9C1 BEST3 SLC25A4 SLC28A1 SLC9C2 SLC29A3 BEST1 BEST4 SLC25A6 SLN SLC27A4 SLC29A2 SLC39A6 SLC28A3 SLC16A7 SLC39A5 SLC16A8 SLC39A8 SLC26A11 SLC39A7 SLC39A2 SLC16A3 SLC39A1 SLC39A3 SLC15A1 SLC38A1 SLC15A2 ATP11C ATP11B ATP11A SLC9B1 SLC9B2 RHCG SLC26A1 IREB2 CLCA2 CLCA1 SLC15A3 SLC38A3 SLC15A4 SLC38A2 SLC26A2 CLCA4 SLC38A5 SLC38A4 SLC14A1 SLC14A2 ATP8B4 ATP8B3 ATP8B2 ATP8B1 SLC4A10 CYBRD1 PIP SLC26A7 ACO1 SLC26A9 SLC26A6 TCIRG1 UNC80 ATP7B MB SLC13A1 SLC36A1 SLC13A2 TRPC5 SLC13A3 SLC13A4 AVP TRPC4 TRPC1 NGB ASPH SLC47A2 SLC47A1 ATP10D SLC5A11 ATP10B SLC5A12 ATP10A SLC5A10 SLC25A26 SLC25A29 PLN LRRC8C BSND LRRC8D LRRC8A LRRC8B SLC13A5 ATP9B ATP9A LRRC8E SLC12A2 SLC12A4 MCOLN3 SLC12A5 TRPA1 CLCA3P CTNS MCOLN1 MCOLN2 TPCN2 TPCN1 UNC79 SLC5A6 SLC46A1 AHCYL2 NIPAL4 NIPAL1 NIPAL2 NIPAL3 ATP6V1E1 SLC12A7 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 SLC6A15 SLC6A13 AZGP1 VDAC3 VDAC2 VDAC1 ATP6V0D1 ATP6V0D2 SLC22A6 SLC45A3 WNK4 TRPM1 TRPM2 ANKH ATP6V0A2 ATP6V0A4 TRPM7 TRPM8 RAB11FIP2 TRPM5 TRPM6 ATP6V1C1 TRPM3 ATP6V0A1 ATP6V1C2 TRPM4 SLC10A6 ATP4B ATP4A WNK1 MYO5B WNK2 WNK3 SLC22A8 SLC22A7 CUTC MRS2 SLC44A5 RYR1 RYR2 SLC44A3 SLC44A4 SLC44A2 SLC7A11 SLC7A10 RYR3 SLC22A17 CLIC2 SLC22A11 ATP6V0B SLC32A1 TSC22D3 ANO8 ANO9 ANO6 FTL HBA2 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 ATP6V0C SGK2 SLC43A2 SLC66A1 SLC20A1 SLC43A1 FTMT ATP6V1G3 ATP6V0E2 MFSD4B PEX19 SLC31A1 FKBP1B HFE SLC30A7 SLC30A6 SLC30A8 SLC30A3 MMGT1 SLC30A2 SLC30A5 ATP1B3 TFRC SLC30A1 ATP1B2 ATP1B1 TRPC4AP SCNN1G SCNN1D SCNN1B SCNN1A STEAP2 ABCG4 ABCG2 ATP6V1A SLC41A2 SLC1A2 SLC41A1 SLC1A4 SLC1A6 SLC1A7 NALCN ASIC4 ASIC5 ASIC2 ATP6V1D ASIC3 ATP6V1F AVPR2 ASIC1 TRPV2 TRPV3 TRPV1 TRPV6 TRPV4 EIF2S2 TRPV5 EIF2S1 ABCD2 EIF2S3 ABCD3 SLC2A3 SLC2A6 SLC2A7 CA1 CA2 CA4 ABCC4 ABCC1 ATP6AP1 SLC1A5 GLRX3 ABCC5 TRDN PEX3 ATP6V1B2 ATP6V1B1 STOML3 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP2C2 ADD3 CLCN3 ATP2C1 CLCN2 ADD1 CYGB CLCN1 ADD2 CAND1 STOM ABCF1 ATP13A1 SLC50A1 SLC4A7 CLCN7 CLCN6 SLC4A8 SLC4A9 CLCN5 CLCN4 ATP13A4 ATP13A5 ATP13A2 FTH1 BSG CFTR A2M TF FURIN NEDD8 RAB11A ATP7A STOML2 MCUB SPG7 PHB MAIP1 PHB2 SLC11A1 PARL AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 TRPC7 PDZD11 TRPC6 TRPC3 SLC2A4 SLC2A8 SRI LCN2 APOB ATP2B4 SGK1 ATP2B3 ATP2B2 ATP2B1 CLTC SLC8A3 CALM1 SLC6A12 SLC6A11 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A1 CAMK2B SLC5A5 CAMK2D CAMK2A CAMK2G AQP12A AQP8 AQP10 AQP9 SLC6A7 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 MIP AQP11 SLC44A1 PRKACG PRKACB SLC7A5 ADCY9 PRKAR1B PRKAR1A PRKAR2A STEAP3 GNAS ABCC3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 SLC34A1 SLC25A10 SLC5A8 SLC25A18 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A1 SLC25A22 HMOX1 RHO GTPASES ACTIVATE WASPS AND WAVES%REACTOME%R-HSA-5663213.1 RHO GTPases Activate WASPs and WAVEs WASF3 ABL1 NCKAP1L WASF1 NCKIPSD WASF2 CYFIP1 NCKAP1 ARPC4 BAIAP2 ARPC5 BTK MAPK1 CYFIP2 BRK1 ABI2 ARPC1B ARPC2 ABI1 ACTG1 MAPK3 ARPC3 WIPF1 WIPF2 WIPF3 WAS PTK2 ACTB ACTR2 ARPC1A WASL RAC1 CDC42 NCK1 CREATINE METABOLISM%REACTOME%R-HSA-71288.1 Creatine metabolism SLC6A11 CKB CKM CKMT2 CKMT1B SLC6A7 GAMT SLC6A8 GATM SLC6A12 BETA OXIDATION OF MYRISTOYL-COA TO LAUROYL-COA%REACTOME%R-HSA-77285.2 Beta oxidation of myristoyl-CoA to lauroyl-CoA HADHB HADHA ACADL REGULATION OF TP53 ACTIVITY THROUGH ACETYLATION%REACTOME%R-HSA-6804758.3 Regulation of TP53 Activity through Acetylation HDAC2 HDAC1 MEAF6 TP53 RBBP4 MAP2K6 RBBP7 MTA2 BRPF1 BRPF3 MBD3 AKT2 ING5 ING2 GATAD2B PIP4P1 AKT1 PML GATAD2A CHD4 CHD3 BRD1 EP300 BRD7 PIP4K2A PIP4K2B PIN1 PIP4K2C KAT6A AKT3 DEFECTIVE CHST3 CAUSES SEDCJD%REACTOME%R-HSA-3595172.1 Defective CHST3 causes SEDCJD CSPG5 CSPG4 BCAN CHST3 NCAN DCN BGN VCAN DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH6%REACTOME%R-HSA-5632968.1 Defective Mismatch Repair Associated With MSH6 MSH6 MSH2 GLOBAL GENOME NUCLEOTIDE EXCISION REPAIR (GG-NER)%REACTOME%R-HSA-5696399.1 Global Genome Nucleotide Excision Repair (GG-NER) POLD2 MCRS1 XRCC1 INO80 POLE4 ERCC4 ERCC1 PIAS1 POLE2 POLE3 ERCC5 SUMO1 SUMO3 SUMO2 DDB2 RBX1 PCNA CCNH YY1 RFC5 GTF2H1 GTF2H2 ACTB RFC3 RFC4 GTF2H3 RFC2 GTF2H4 CETN2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RPA1 RPA2 RPA3 GPS1 UBA52 COPS4 COPS2 UBB RUVBL1 UBC POLK NFRKB POLE RPS27A RNF111 LIG1 PARP1 RFC1 PARP2 DDB1 ACTR5 USP45 ACTL6A XPA LIG3 COPS7B RAD23A COPS7A ACTR8 CUL4A CHD1L COPS3 RAD23B UBE2V2 COPS6 INO80C COPS5 INO80B INO80E INO80D XPC COPS8 POLD3 CUL4B PIAS3 TFPT UBE2N POLD4 UBE2I POLD1 SIGNALING BY EXTRACELLULAR DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 76%9680187 Signaling by extracellular domain mutants of KIT KIT DEFECTIVE PYROPTOSIS%REACTOME%R-HSA-9710421.1 Defective pyroptosis H3C15 RBBP4 PRIM2 PRIM1 H2BS1 RBBP7 POLA1 POLA2 GSDME DNMT1 H2AZ1 H2BC9 H2AZ2 EZH2 H4C9 H2BC8 H2BC5 DNMT3B H2BC3 EED H2BC1 H2AX H2AB1 H2AC20 H2AC19 SUZ12 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRON-CONTAINING TRANSCRIPT%REACTOME DATABASE ID RELEASE 76%159236 Transport of Mature mRNA derived from an Intron-Containing Transcript NUP42 NUP43 RAE1 RANBP2 NXT1 NUP35 EIF4A3 CASC3 NUP37 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 DDX39A DDX39B ZC3H11A SARNP SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 SEC13 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 SRRM1 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NCBP1 NUP214 NUP153 NCBP2 NUP62 NDC1 NUP133 NUP50 NUP54 RELEASE%REACTOME DATABASE ID RELEASE 76%168298 Release PA PB2 NP NA NS HA M PB1 REGULATION OF IFNG SIGNALING%REACTOME%R-HSA-877312.2 Regulation of IFNG signaling PTPN1 JAK2 PIAS1 SOCS1 IFNG PTPN6 IFNGR1 IFNGR2 SUMO1 JAK1 PTPN11 SOCS3 ROLE OF SECOND MESSENGERS IN NETRIN-1 SIGNALING%REACTOME%R-HSA-418890.1 Role of second messengers in netrin-1 signaling TRPC7 TRPC6 PLCG1 TRPC5 TRPC3 DCC TRPC4 PITPNA TRPC1 NTN1 CONDENSATION OF PROMETAPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 76%2514853 Condensation of Prometaphase Chromosomes NCAPG CSNK2A1 NCAPD2 SMC4 NCAPH CSNK2A2 SMC2 CSNK2B CDK1 CCNB2 CCNB1 DEFECTIVE GNE CAUSES SIALURIA, NONAKA MYOPATHY AND INCLUSION BODY MYOPATHY 2%REACTOME%R-HSA-4085011.1 Defective GNE causes sialuria, Nonaka myopathy and inclusion body myopathy 2 GNE BH3-ONLY PROTEINS ASSOCIATE WITH AND INACTIVATE ANTI-APOPTOTIC BCL-2 MEMBERS%REACTOME%R-HSA-111453.5 BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members BCL2L11 BCL2 BID BCL2L1 STAT3 BBC3 PMAIP1 BMF BAD ACTIVATED NTRK3 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 76%9034864 Activated NTRK3 signals through RAS HRAS SOS1 NRAS NTRK3 NTF3 SIGNALING BY TGF-BETA RECEPTOR COMPLEX IN CANCER%REACTOME%R-HSA-3304351.2 Signaling by TGF-beta Receptor Complex in Cancer TGFB1 SMAD4 SMAD3 TGFBR1 TGFBR2 FKBP1A SMAD2 CYTOSOLIC SENSORS OF PATHOGEN-ASSOCIATED DNA%REACTOME%R-HSA-1834949.1 Cytosolic sensors of pathogen-associated DNA CREBBP CTNNB1 RIPK1 POLR2E POLR2F POLR2H POLR2K POLR2L EP300 TBK1 IRF3 RIPK3 DHX9 NFKB1 NKIRAS1 POLR1C NKIRAS2 POLR1D TLR3 NFKBIB MYD88 CRCP CGAS TICAM1 DDX41 LRRFIP1 TRIM21 IRF7 TRIM56 PRKDC NLRC3 IFI16 DHX36 STAT6 UBA52 XRCC6 POLR3GL XRCC5 TREX1 POLR3A STING1 POLR3B ZBP1 POLR3C NLRP4 POLR3D DTX4 POLR3E POLR3F POLR3G POLR3H POLR3K UBB TRIM32 IKBKB CHUK UBC NFKBIA RELA RPS27A IKBKG NFKB2 MRE11 INSULIN RECEPTOR SIGNALLING CASCADE%REACTOME%R-HSA-74751.3 Insulin receptor signalling cascade SHC1 GAB1 PIK3CA FLT3 SOS1 MAPK1 AKT2 MAPK3 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 NRAS FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 INSR FLT3LG FRS2 GRB10 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 PIK3C3 FGFR4 PIK3R2 FGF10 INS SYNTHESIS OF IPS IN THE NUCLEUS%REACTOME%R-HSA-1855191.2 Synthesis of IPs in the nucleus IP6K1 IP6K2 IPPK IPMK DEUBIQUITINATION%REACTOME DATABASE ID RELEASE 76%5688426 Deubiquitination TAB1 YY1 ARRB1 ARRB2 HGS CCP110 GATA3 UBA52 NLRP3 UBB RUVBL1 UBC NFRKB RPS27A ACTR5 ACTL6A MYC RAD23A ACTR8 RAD23B INO80C INO80B CDK1 INO80E INO80D TFPT MCRS1 CFTR INO80 SMAD4 ESR1 SMAD3 SMURF2 AR TAF9B STAM TAF10 USP4 USP2 H2AC19 ACTB OTUD5 H2AC14 H2BC21 EP300 H2BU1 USP13 RNF146 TNFAIP3 H2AC8 H2AC6 H2AC7 OTUD3 H2BC17 H2BC12 H2BC13 KAT2B UBE2D1 CYLD H2BC14 CDC25A KAT2A H2BC15 TRAF3 OTUD7B H2BC11 PSMD8 NEDD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 H2BC9 PSME2 BIRC2 PSMD10 BIRC3 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 PSMD14 H2BC3 PSMD13 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 OTUB2 USP21 OTUD7A PSMB7 H2AC20 PSMB4 VCPIP1 ZRANB1 PSMB5 YOD1 IFIH1 PSMB2 PSMB3 APC RNF128 RNF135 PSMB1 PSMF1 MAVS TNIP1 TNIP2 PSMB8 DDX58 TNIP3 PSMB9 OTUB1 TRIM25 SEM1 IKBKG PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 PSMC2 STAM2 SMAD2 TRRAP KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 USP17L30 HCFC1 RNF123 BRCC3 BARD1 SNX3 RHOT1 RIPK1 RCE1 TRAF2 SIAH2 TADA2B H2AC21 BAP1 H2AW WDR48 IDE BABAM1 BABAM2 UCHL1 BRCA1 UIMC1 UFD1 TOMM70 JOSD2 UCHL3 JOSD1 UCHL5 PTRH2 PRKN WDR20 USP17L21 USP17L20 USP17L22 STAMBPL1 USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP17L19 USP17L10 USP17L2 USP17L12 USP17L3 USP17L11 USP17L1 USP17L13 KDM1B TOMM20 ATXN3L USP8 USP5 USP3 MUL1 H2AC1 FKBP8 STAMBP FOXO4 ATXN3 ATXN7 CLSPN USP9X SMAD1 USP11 SMAD7 TADA3 OGT USP37 USP33 USP34 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 SUDS3 USP42 USP44 AXIN1 AXIN2 H2BC18 BECN1 USP14 USP15 USP16 USP10 ABRAXAS1 USP12 FOXK2 FOXK1 ABRAXAS2 MAT2B USP18 USP19 CDC20 USP24 USP25 USP26 USP20 USP22 ADRM1 USP28 ASXL1 ASXL2 CCNA2 CCNA1 TP53 MDM2 MDM4 DDB2 SKP2 VDAC3 VDAC2 VDAC1 PTEN IL33 HIF1A NFKBIA ADRB2 TNKS2 TNKS TGFB1 NOD1 NOD2 TGFBR1 RIPK2 RHOA TGFBR2 TRAF6 MAP3K7 CATION-COUPLED CHLORIDE COTRANSPORTERS%REACTOME%R-HSA-426117.1 Cation-coupled Chloride cotransporters SLC12A2 SLC12A4 SLC12A5 SLC12A7 SLC12A3 SLC12A1 SLC12A6 DISEASES OF MITOTIC CELL CYCLE%REACTOME DATABASE ID RELEASE 76%9675126 Diseases of mitotic cell cycle CCNE2 CCNE1 CDK2 SKP2 CDKN1C RB1 CCND3 TFDP1 FZR1 CDK6 CCND2 TFDP2 CCND1 CDK4 E2F1 DAXX E2F2 ATRX E2F3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDKN1A CDC27 CDKN1B ANAPC4 ANAPC5 ANAPC1 EFFECTS OF PIP2 HYDROLYSIS%REACTOME%R-HSA-114508.2 Effects of PIP2 hydrolysis MGLL TRPC7 TRPC6 TRPC3 ITPR1 ITPR2 ITPR3 PRKCD PRKCE RASGRP2 DGKG RASGRP1 DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ PRKCQ DAGLB DGKK DGKI DGKH ABNORMAL CONVERSION OF 2-OXOGLUTARATE TO 2-HYDROXYGLUTARATE%REACTOME DATABASE ID RELEASE 76%2978092 Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate IDH1 DEGRADATION OF AXIN%REACTOME DATABASE ID RELEASE 76%4641257 Degradation of AXIN SMURF2 RNF146 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 AXIN1 UBA52 PSMD10 AXIN2 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TNKS2 TNKS ACTIVATION OF GENE EXPRESSION BY SREBF (SREBP)%REACTOME DATABASE ID RELEASE 76%2426168 Activation of gene expression by SREBF (SREBP) TM7SF2 CREBBP PMVK SC5D FDFT1 FDPS NFYA HMGCS1 GGPS1 NFYB NFYC CYP51A1 RXRA ELOVL6 LSS SREBF2 SQLE SCD SP1 MTF1 DHCR7 PPARA MVD ACACA NCOA1 MED1 NCOA2 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X FASN GPAM IDI1 MVK ACACB TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY DREAM COMPLEX%REACTOME DATABASE ID RELEASE 76%1362277 Transcription of E2F targets under negative control by DREAM complex HDAC1 TFDP1 TFDP2 RBBP4 E2F1 CDC6 LIN54 RBL2 RBL1 LIN52 PCNA MYC E2F4 TOP2A LIN37 MAX LIN9 CDC25A E2F5 LOSS OF PHOSPHORYLATION OF MECP2 AT T308%REACTOME%R-HSA-9022535.1 Loss of phosphorylation of MECP2 at T308 CAMK4 PRKACA CALM1 FGFR4 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190322 FGFR4 ligand binding and activation FGF23 KLB FGF16 FGF19 FGF1 FGF18 FGF2 FGF4 FGF6 FGFR4 FGF9 FGF20 G ALPHA (12 13) SIGNALLING EVENTS%REACTOME%R-HSA-416482.5 G alpha (12 13) signalling events SOS1 GNA13 TRIO RASGRF2 ADRA1D MCF2L VAV3 RHOC BTK RHOB ARHGEF16 GNA12 PLXNB1 VAV1 ADRA1B ARHGEF40 GNG10 ADRA1A ARHGEF5 ARHGEF26 PREX1 GNG12 TIAM2 KALRN GNG11 GNG13 OBSCN GNB2 NGEF GNB1 GNB4 GNB3 GNB5 ECT2 GNGT1 VAV2 ARHGEF33 TIAM1 ARHGEF35 GNGT2 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L AKAP13 ABR ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 GNG3 ARHGEF19 GNG2 ARHGEF9 ARHGEF7 ARHGEF3 GNG5 ARHGEF4 ROCK1 GNG4 ARHGEF1 ROCK2 GNG7 ARHGEF2 SOS2 GNG8 MCF2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 PLEKHG5 TBXA2R ARHGEF18 ITSN1 RHOA REGULATED NECROSIS%REACTOME%R-HSA-5218859.3 Regulated Necrosis GSDMD IRF1 IRF2 TP53 3a ELANE CASP8 TRADD RIPK1 GSDME TRAF2 FADD CHMP2B CHMP2A HMGB1 SDCBP IL18 IL1A IL1B CASP5 CASP3 CASP4 FLOT1 UL36 PDCD6IP RIR1 PELI1 BAK1 MLKL GZMB HSP90AA1 CDC37 NS STUB1 CHMP3 CHMP6 CRMA CHMP7 RIPK3 SPI-2 CYCS OGT FASLG CASP1 FAS BIRC2 UBA52 BIRC3 XIAP BAX TNFSF10 FLOT2 TNFRSF10B TNFRSF10A UBB UBC RPS27A CHMP4C CHMP4B CHMP4A TP63 BETA-OXIDATION OF VERY LONG CHAIN FATTY ACIDS%REACTOME%R-HSA-390247.3 Beta-oxidation of very long chain fatty acids ABCD1 ACOT8 EHHADH DECR2 ACOT6 ACAA1 ACOT4 HSD17B4 IKBA VARIANT LEADS TO EDA-ID%REACTOME%R-HSA-5603029.2 IkBA variant leads to EDA-ID IKBKB CHUK NFKBIA RELA IKBKG NFKB1 NFKB2 SYNTHESIS OF PI%REACTOME%R-HSA-1483226.3 Synthesis of PI CDS1 PITPNM1 PITPNM3 PITPNM2 CDIPT APC-CDC20 MEDIATED DEGRADATION OF NEK2A%REACTOME DATABASE ID RELEASE 76%179409 APC-Cdc20 mediated degradation of Nek2A UBA52 UBB CDC20 UBC RPS27A BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 NRCAM INTERACTIONS%REACTOME%R-HSA-447038.1 NrCAM interactions NRP2 CNTN2 NRCAM ANK1 DLG1 DLG3 DLG4 PRESYNAPTIC FUNCTION OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 76%500657 Presynaptic function of Kainate receptors GNG12 PLCB3 GNG11 PLCB1 GNG13 PLCB2 GNB2 GNB1 GNG3 GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 GNGT1 GRIK3 GNGT2 GNG10 POTENTIAL THERAPEUTICS FOR SARS%REACTOME%R-HSA-9679191.2 Potential therapeutics for SARS NR3C1 ACE2 RIPK1 ITGB1 ATP1B3 ATP1B2 ATP1B1 KDM1A CHD4 CHD3 HSP90AA1 TBK1 FXYD4 FXYD3 AP2A1 FXYD2 FXYD1 FXYD7 ARID4A AP2A2 FXYD6 NS5B JAK3 IL6R IL1R1 SIGMAR1 IFNGR1 BRMS1 FURIN AP2M1 IFNGR2 TLR7 JAK1 IFNAR1 PHF21A BRD4 HSP90AB1 CRBN STAT2 REST TUBB HDAC2 IMPDH1 HDAC1 PTGES3 IMPDH2 PDCD1 ATP1A4 ATP1A3 MTA1 FKBP4 ATP1A2 ATP1A1 RBBP4 S1PR1 ARID4B RBBP7 MTA2 TYK2 SAP30 ROCK1 ROCK2 MTA3 SUDS3 MBD3 CYSLTR1 AP2S1 RCOR1 ZBP1 COMT GATAD2B GATAD2A SAP30L AP2B1 SAP18 HMG20B JAK2 ITGA4 TLR9 FKBP1A SIGNALLING TO ERK5%REACTOME%R-HSA-198765.1 Signalling to ERK5 MAPK7 MAP2K5 SIGNALING BY MST1%REACTOME%R-HSA-8852405.1 Signaling by MST1 SPINT1 MST1 HPN MST1R SPINT2 ANTIMICROBIAL ACTION AND ANTIMICROBIAL RESISTANCE IN MTB%REACTOME DATABASE ID RELEASE 76%9639775 Antimicrobial action and antimicrobial resistance in Mtb rpoA rpoC rpoZ SIGNALING BY INSULIN RECEPTOR%REACTOME%R-HSA-74752.1 Signaling by Insulin receptor TCIRG1 ATP6V1G3 ATP6V0E2 SHC1 GAB1 PIK3CA FLT3 SOS1 ATP6V1H MAPK1 MAPK3 ATP6V1A PDPK1 ATP6V1D ATP6V1F PTPN11 PIK3R1 GRB10 TRIB3 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6AP1 PIK3R2 INS ATP6V1B2 ATP6V1B1 ATP6V0D1 ATP6V0D2 ATP6V0A2 ATP6V0A4 ATP6V1C1 ATP6V0A1 ATP6V1C2 AKT2 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 NRAS FGF7 FGF9 ATP6V0B FGF20 THEM4 FGF23 FGF22 INSR FLT3LG FRS2 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 ATP6V0C FGF10 INFECTION WITH MYCOBACTERIUM TUBERCULOSIS%REACTOME DATABASE ID RELEASE 76%9635486 Infection with Mycobacterium tuberculosis GSK3A ENO1 DUSP16 B2M CORO1A eis lpdC esxH esxG RNF213 esxA Rv1410c PGK1 ATP6V1H MAPK1 TRIM27 sapM Rv3655c ndkA MAPK3 CTSG KPNA1 Rv3364c ptpA secA2 NOS2 VPS33B PPE2 lprG lprM SFPQ HGS RAB5A KPNB1 Rv3654c RAB7A rpoA rpoC rpoZ Rv1281c msrA irtB irtA Rv2779c sodC sodB UBA52 ahpE ahpD MRC1 ahpC katG secY secF secE Rv1280c secA1 secG secD Rv2895c MT2748 UBB bfr pstS1 dlaT mscR UBC Rv1283c trx-2 RPS27A Rv1282c glbN fgd1 ggt-1 trxA bfrB cpnT tpx trxB TLR2 LTF RNA POLYMERASE II HIV PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 76%167162 RNA Polymerase II HIV Promoter Escape GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 RAC2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013404 RAC2 GTPase cycle DOCK2 DOCK1 PIK3CA ITGB1 CYFIP1 NCKAP1 ANKLE2 TRIO TFRC NCF1 ARHGDIA NCF2 VAV3 NCF4 ARHGAP1 BRK1 ARHGAP39 VAV1 ARHGAP35 DOCK10 PREX1 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ERBIN VAPB LBR EMD TMPO SWAP70 RAB7A CYBB CYBA VRK2 LEMD3 VAV2 PIK3R1 BCR IQGAP1 TIAM1 CDC42EP1 CDC42 DSG2 PAK1 VAMP3 GARRE1 ARHGAP17 GIT1 PIK3R2 LMAN1 GIT2 ARHGAP21 ABR PGRMC2 RACGAP1 NHS SLITRK5 VANGL1 DEPDC1B NCKAP1L WASF2 EPHA2 PAK4 CAV1 MCAM MCF2 ARHGAP26 MPP7 ARHGAP32 DIAPH3 ABI2 TAOK3 DOCK4 ABI1 DOCK3 ESYT1 PAK2 LAMTOR1 RAC2 ARMCX3 CDC42EP4 PIK3R3 PLD2 SAMM50 MTX1 DEF6 ENOS ACTIVATION%REACTOME DATABASE ID RELEASE 76%203615 eNOS activation CAV1 HSP90AA1 NOS3 LYPLA1 SPR CALM1 DDAH1 DDAH2 AKT1 ZDHHC21 CYGB RHOF GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9035034 RHOF GTPase cycle FAM169A TOR1AIP1 ARHGAP21 AKAP12 BAIAP2L2 BASP1 POTEE FARP1 ACTN1 VANGL1 RHOF DEPDC1B SENP1 ADD3 DIAPH1 SRGAP2 DIAPH2 CAV1 MCAM SNAP23 SLC4A7 ARHGAP32 ARHGAP1 DIAPH3 ARHGAP39 ARHGAP5 STEAP3 ESYT1 SYDE1 BAIAP2L1 ACTB LMNB1 TMPO CAPZB RAB7A MYO9B PIK3R1 ARHGAP12 VAMP3 PIK3R2 MTMR1 SOWAHC TRP CHANNELS%REACTOME DATABASE ID RELEASE 76%3295583 TRP channels TRPC7 TRPM1 TRPM2 TRPC6 TRPC5 TRPC3 TRPM7 TRPC4 TRPM8 TRPC1 TRPM5 TRPM6 TRPM3 TRPC4AP TRPM4 MCOLN3 TRPA1 TRPV2 MCOLN1 TRPV3 MCOLN2 TRPV1 TRPV6 TRPV4 TRPV5 SENSORY PROCESSING OF SOUND BY OUTER HAIR CELLS OF THE COCHLEA%REACTOME%R-HSA-9662361.1 Sensory processing of sound by outer hair cells of the cochlea CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 TPRN PLS1 TMC1 KCNMA1 MYO7A TMC2 MYO3B CASK MYO3A KCNQ4 FSCN2 EZR PCDH15 USH1C TWF2 TWF1 ESPNL EPB41L1 EPB41L3 KCNMB1 CDH23 OTOG XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 GSN WHRN RDX MYH9 LHFPL5 MSN OTOGL CHRNA9 TMIE CHRNA10 USH1G KCNN2 MYO15A STRC SLC26A5 SPTAN1 SPTBN1 MYO1C AXON GUIDANCE%REACTOME DATABASE ID RELEASE 76%422475 Axon guidance EPHB6 MYL12A EFNB2 EFNB1 SDCBP EFNB3 FYN PAK3 EPHB2 MAPK1 EPHB1 EPHB4 EPHB3 EZR MAPK3 HSP90AA1 ERBB2 RDX MSN MYO9B ALCAM PRKACA DPYSL4 DPYSL5 RPL4 SCN11A RPL5 DPYSL2 RPL30 DPYSL3 RPL3 HOXA2 RPL32 UNC5A RPL31 UNC5B RPL34 UNC5C UNC5D RPLP1 ISL1 RPL10L MYL6 RPLP0 SCN10A RPL10A RPL8 MYL9 ABL1 RPL6 AGAP2 RPL7 FLRT3 UPF3A RPS4X L1CAM RPS15 RET RPL7A CHL1 RPS14 UPF2 RPS17 LYPLA2 RPS16 DSCAML1 RPL18A ZSWIM8 RPS19 FARP2 RPS18 SEMA5A RPL36AL RPL36 PLXND1 CDK5 RPL35 ITGA2B KIF4B RPLP2 MSI1 RPL38 UBA52 PLXNC1 KIF4A RPL37 MAP2K1 SEMA6A RPS11 RPL39 MAP2K2 SEMA6D RPS10 CACNB1 RPS13 CACNB2 RPS12 CACNB3 RPS9 CACNB4 RPS7 SEMA7A RPL21 SHC3 PLXNA2 NCBP1 RPS8 PLXNA1 SRGAP3 NCBP2 RPS5 SRGAP1 UBB RPL23 PLXNA4 RPL22 PLXNA3 RPS6 PTPRC DAB1 RPL13A UBC RPSA LHX3 PTPRA RPS3A RPS27A LHX2 RPL9P9 ITGA10 RPL37A RPL24 PLXNB3 RPL27 LHX4 CLASP1 LHX9 ETF1 RPL26 CNTNAP1 RPL29 ITGB3 RPL28 PIK3CD RPS4Y2 TREM2 RPL10 ITGAV RAC1 RPL12 NEO1 RPL11 ITGA2 ITGA1 RPL36A RPS27L EVL RPS4Y1 ITGA5 MET GSPT2 ITGA9 GSPT1 RPS15A SEMA3A RPL14 NTN4 RPS3 SEMA3E RPL13 ABLIM1 RPS2 ABLIM2 RPL15 ABLIM3 RPL18 SEMA4A RPL17 SEMA4D RPL19 NELL2 NFASC RPL39L RPL41 RPS6KA4 MYO10 RPL35A DAG1 RPL23A SCN1B RPL3L SCN1A DOCK1 ELOB EPHA5 RPS26 ELOC EPHA4 RPS25 EPHA7 RPS28 EPHA6 RPS27 EPHA8 RPS29 SHTN1 RPL27A RPL22L1 KCNQ2 KCNQ3 RPS20 EPHA1 FAU TLN1 RPS21 PFN1 RPL26L1 EPHA3 RPS24 PFN2 RPS23 GRB7 EPHA10 GRIN2B MYL12B RPS6KA6 RRAS GRIN1 SCN3B SCN3A DLG1 VASP SIAH1 DLG3 ARTN CD24 DLG4 SCN2A SCN2B ROBO2 NRP1 ROBO1 CAP1 ACTB GFRA1 GFRA3 RGMB GFRA2 GFRA4 RGMA ENAH AKAP5 RELN PAK5 CAP2 CLTA CD72 AP2A1 RANBP9 SCN9A VLDLR NRTN DSCAM AP2A2 DOK2 TYROBP DOK4 DOK5 DOK6 SCN8A CACNA1D AP2M1 CACNA1C EFNA5 EFNA4 PSMD8 CACNA1H PSMD9 CACNA1G PSMD6 CACNA1I PSMD7 MYH14 PSMD4 MYH11 CACNA1S PSMD5 MYH10 PSMD2 PRNP PSMD3 PSPN PSMD1 CNTN6 PSMA5 EFNA1 PSMA6 EFNA3 EFNA2 PSMA3 GDNF PSMA4 FES PSMA1 CNTN1 PSMA2 LDB1 PSME3 RND1 PSME4 HJV PSME1 SCN5A PSME2 GAP43 PSMD10 DCX SCN4A PSMB11 PSMD12 SHANK3 AP2S1 PSMD11 SCN4B PSMD14 LAMA1 PSMD13 CRMP1 SLIT1 PSMA7 SCN7A PSMB10 SLIT3 PSMA8 NCAM1 PSMB6 SLIT2 PSMB7 PDLIM7 PSMB4 CLASP2 PSMB5 MAPK12 PSMB2 AP2B1 MAPK13 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RAP1GAP PSMC2 CSNK2A1 CSNK2A2 VAV3 CSNK2B KALRN HSP90AB1 ARHGEF28 ARPC1B ACTG1 CFL1 LYN YES1 LIMK2 LIMK1 PTK2 SDC2 ITSN1 GPC1 SHC1 GAB1 PIK3CA PLCG1 TRPC5 SOS1 TRPC4 TRPC1 AGRN PIP5K1C CXCR4 ST8SIA4 ARPC1A CLTB ST8SIA2 EGFR CLTCL1 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 CXCL12 COL4A5 COL6A3 COL6A6 COL6A5 ITGB1 TRIO ARPC4 ARPC5 RPS6KA3 RPS6KA5 RPS6KA2 ARHGAP39 ARPC2 RPS6KA1 ARPC3 ARHGAP35 ACTR2 VAV2 TIAM1 SPTB GRB10 PIK3R2 ABL2 SRGAP2 PAK4 ADAM10 ANK2 ANK3 ANK1 SRC PSEN1 SPTBN4 NCSTN SPTBN5 COL9A1 COL9A3 COL9A2 EIF4A3 SPTBN2 CASC3 LAMC1 MAGOH SH3KBP1 NGEF MMP2 RBM8A MMP9 PSEN2 APH1A APH1B UPF3B MAGOHB RNPS1 DCC PITPNA NTN1 PSENEN ARHGEF11 LAMB1 ARHGEF12 SOS2 SH3GL2 IRS2 PIK3CB FRS2 GAB2 SPTA1 TRPC7 TRPC6 TRPC3 SIAH2 DNM1 DNM2 DNM3 HSPA8 PTPN11 MYH9 CLTC WASL PIK3R1 CDC42 PAK1 NCK2 PAK6 MAPK8 SPTAN1 GIT1 CDK5R1 SPTBN1 NCK1 CUL2 USP33 ARHGEF7 EPHA2 GSK3B PRKCA MAPK7 PABPC1 CREB1 MAPK14 MAPK11 PRKCQ EIF4G1 PRKACG PRKACB RBX1 RHOC RHOB PLXNB1 PRKAR2A NUMB NRP2 CNTN2 NRCAM NCAN ROCK1 ROCK2 HRAS RASA1 NRAS DOK1 PIK3R3 RHOA PPP3CB DEFECTIVE PRO-SFTPC CAUSES SMDP2 AND RDS%REACTOME%R-HSA-5688354.2 Defective pro-SFTPC causes SMDP2 and RDS SFTPC DIGESTION OF DIETARY LIPID%REACTOME DATABASE ID RELEASE 76%192456 Digestion of dietary lipid PNLIP LIPF PNLIPRP1 PNLIPRP2 CEL PNLIPRP3 CLPS DEFECTIVE CHST14 CAUSES EDS, MUSCULOCONTRACTURAL TYPE%REACTOME DATABASE ID RELEASE 76%3595174 Defective CHST14 causes EDS, musculocontractural type CHST14 CSPG5 CSPG4 BCAN NCAN DCN BGN VCAN INTRINSIC PATHWAY FOR APOPTOSIS%REACTOME%R-HSA-109606.3 Intrinsic Pathway for Apoptosis GSDMD BCL2L11 TP53 PPP3R1 CDKN2A BBC3 TP53BP2 CASP8 GSDME TP73 BID MAPK1 PPP1R13B YWHAQ CASP3 SFN YWHAH MAPK3 BAK1 GZMB YWHAE PMAIP1 YWHAG MAPK8 BMF DYNLL2 CYCS C1QBP BCL2 BCL2L1 APAF1 DYNLL1 YWHAB XIAP STAT3 BAX AKT2 APIP AKT1 BAD YWHAZ TFDP1 TFDP2 AVEN CASP9 CASP7 E2F1 PPP3CC DIABLO UACA CARD8 NMT1 TP63 AKT3 AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL%REACTOME%R-HSA-198323.4 AKT phosphorylates targets in the cytosol TSC2 CHUK MDM2 CASP9 GSK3A AKT1S1 MKRN1 GSK3B AKT2 CDKN1A CDKN1B AKT1 BAD AKT3 DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BARD1 LOSS OF FUNCTION%REACTOME%R-HSA-9699150.2 Defective DNA double strand break response due to BARD1 loss of function BRCA1 BARD1 MRNA EDITING: A TO I CONVERSION%REACTOME DATABASE ID RELEASE 76%75064 mRNA Editing: A to I Conversion ADAR ADARB1 FOLDING OF ACTIN BY CCT TRIC%REACTOME DATABASE ID RELEASE 76%390450 Folding of actin by CCT TriC CCT8 CCT5 CCT6A ACTB CCT4 CCT6B CCT3 CCT2 TCP1 CCT7 SIGNALING BY EGFRVIII IN CANCER%REACTOME%R-HSA-5637812.1 Signaling by EGFRvIII in Cancer HSP90AA1 CDC37 HRAS SHC1 GAB1 PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 EGFR CBL REGULATION OF BETA-CELL DEVELOPMENT%REACTOME DATABASE ID RELEASE 76%186712 Regulation of beta-cell development CREBBP PTF1A FOXA3 HES1 IAPP FOXA2 NEUROG3 SNW1 MAMLD1 GCK FOXO1 AKT2 AKT1 EP300 SLC2A2 MAML2 MAML1 RBPJ ONECUT3 ONECUT1 KAT2B HNF4G NEUROD1 NKX6-1 KAT2A NKX2-2 PAX4 PDX1 PAX6 MAML3 HNF1B NOTCH1 HNF1A MAFA FGF10 INS RFX6 AKT3 INSM1 SIGNALING BY RHO GTPASES, MIRO GTPASES AND RHOBTB3%REACTOME DATABASE ID RELEASE 76%9716542 Signaling by Rho GTPases, Miro GTPases and RHOBTB3 FAM169A TOR1AIP1 AKAP12 PRKCB BAIAP2L2 BASP1 POTEE FARP1 ACTN1 RHOF SENP1 DIAPH1 DIAPH2 PAK3 MAPK1 MAPK3 TWF1 WAS KDM1A HSP90AA1 DOCK11 CDC37 KIF5B ERBIN KIF5A HGS YWHAE CCP110 RAB7A PPP1CB MYO9B PPP2R1A YWHAG KLC1 PPP1R12A KLC4 KLC3 KLC2 MYL6 MYL9 ABL1 DYNLL1 CKAP5 NCKIPSD FARP2 KIF18A PLXND1 MAPRE1 DVL1 DVL3 PAFAH1B1 DOCK6 DYNC1I2 DOCK5 DOCK4 DOCK3 PLXNA1 DOCK9 SRGAP3 DOCK8 SRGAP1 DOCK7 CAPZB CLASP1 DYNC1H1 NDE1 RAC1 PLK1 EVL KIF2A WASF3 KIF2C KIF2B DOCK2 DOCK1 MFN1 MFN2 AR RPS27 LCK CENPE PFN1 PFN2 RASGRF2 GRB7 MYL12B LIN7B H2AX DLG4 H2AB1 H2AC19 ACTB H2AC14 H2BC21 PREX2 H2BU1 WWP2 H3-3B H3C8 H2AC8 PAK5 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 NUP107 H2BC11 MYH14 MYH11 MYH10 H3C15 ARHGAP10 H2BS1 VCP RND1 H2AZ1 H2BC9 H2AZ2 AAAS H4C9 H2BC8 H2BC5 NUP160 NUP85 H2BC3 H2BC1 H2AC20 CLASP2 PAK2 UACA NUP133 STMN2 MYLK WDR91 EPSTI1 NUP43 ANKFY1 STARD8 RANBP2 MRTFA FRS3 WDR81 DAAM1 CDCA8 IQGAP3 SKA1 SKA2 NUP37 ANKLE2 RHOT2 STARD13 ARHGDIG JUP ARHGDIA FAM135A MCF2L CDC42SE2 VAV3 ARHGAP9 PLEKHG3 ARHGAP8 ARHGEF16 OSBPL11 RHOG ARHGAP4 VAV1 LRRC1 NDUFS3 NUF2 ELMO2 NUDC ARHGEF5 RRAS2 ARHGEF26 SHMT2 GMIP LRRC41 PLD1 IQGAP2 CIT CDC42EP5 KALRN HMOX2 INCENP NDUFA5 CDC42EP3 CCT6A HSPE1 CDC42EP2 LETM1 PKN3 VAPB CENPA MAP3K11 CENPC FGD5 CHN2 CHN1 FLNA CENPT CENPU KIDINS220 WDR11 TMEM59 CENPH CENPI TUBA1B SHKBP1 TAOK1 CENPK CENPL CENPM GOPC PKN2 FILIP1 CENPN PKN1 CENPO HSP90AB1 CENPP STIP1 CENPQ CENPS UHRF1BP1L FAM13B FAM13A MSI2 STK10 SLK MEN1 GOLGA8R RALGAPA1 FAM91A1 TEX2 CLIP1 PHIP MAD1L1 RHOBTB2 DDRGK1 NDC80 NSFL1C NF2 ARHGAP11A ARHGAP11B TAGAP EFHD2 SPDL1 PLEKHG4 DDX4 ARHGEF28 ARPC1B PLEKHG1 TNFAIP1 PLEKHG6 ACTG1 RND3 CFL1 RANGAP1 FLOT2 NIPSNAP2 MUC13 PPP1R12B FAM83B DSP SRF LIMK2 ANKRD26 NSL1 LIMK1 PLEKHG5 SH3BP1 PTK2 CSK CDC20 TMOD3 WHAMM SEMA4F SCRIB PPP1R14A PCDH7 PTPN13 CDC42BPB CKAP4 KTN1 CDC42BPA NISCH MYO19 PRC1 CCDC88A VANGL2 PPP1CC CPNE8 GOLGA3 UBXN11 CPD KNL1 SPATA13 KCTD13 DSG1 ROPN1 PKP4 TMEM87A KLK3 PICALM DSN1 SCAI RCC2 ZWINT ANLN AHCTF1 ITSN1 FAF2 FNBP1L KIF14 HINT2 GJA1 SH3PXD2A NDEL1 CCDC115 RHOH RHOD RHOJ TAX1BP3 RHOU MIS12 TRAK1 TRAK2 PLEKHG4B EMC3 FNBP1 CTNNA1 PIK3CA BCAP31 CAVIN1 DYNC1LI1 SOS1 DLC1 DYNC1LI2 B9D2 SPC24 TJP2 SPC25 ERCC6L RTKN PRAG1 ZWILCH SYDE2 ARHGAP44 ARHGAP40 KNTC1 RALBP1 KCTD3 SFN ARHGAP45 ALDH3A2 SGO1 SGO2 ARHGEF25 ARHGAP19 ARHGAP18 PMF1 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 ARPC1A ARHGAP30 DNMBP RND2 ZAP70 GFOD1 CCDC187 RAP1GDS1 MOSPD2 BUB1 KDM4C FMNL3 FMNL1 FMNL2 ACTC1 STX5 LAMTOR1 RHOBTB3 DVL2 GNA13 ITGB1 CYFIP1 NCKAP1 TRIO ARPC4 TFRC NCF1 NCF2 ARPC5 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARPC2 ARHGAP6 ARPC3 ARHGAP35 DOCK10 PREX1 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 LBR EMD TMPO SWAP70 ARAP2 ARAP3 CYBB ACTR2 CYBA OCRL VRK2 LEMD3 VAV2 BCR ARFGAP3 TIAM1 ABCD3 RAPGEF1 CDC42EP1 DSG2 VAMP3 ARFGAP2 GARRE1 AMIGO2 NOXO1 ARHGAP17 PIK3R2 ATP6AP1 SLC1A5 ARHGAP15 LMAN1 CDC25C ARHGAP21 ABR PGRMC2 RACGAP1 SLITRK3 NHS SLITRK5 ABL2 NCKAP1L WASF1 ADD3 SRGAP2 WASF2 YKT6 PAK4 IL32 JAG1 CAV1 MCAM MCF2 STOM BAIAP2 ARHGAP26 MPP7 ARHGAP32 SLC4A7 DIAPH3 ABI2 TAOK3 ABI1 CENPF NOXA1 NOX3 ESYT1 NOX1 FERMT2 CDH1 ARL13B ZW10 KLK2 CFTR SCFD1 CTNNB1 STAM ARHGEF40 DDX39B TIAM2 OBSCN NGEF SEC13 ECT2 CTTN ARHGEF39 RHOQ NET1 PIN1 ARHGEF10L AKAP13 C1QBP ARHGEF11 ARHGEF10 PLEKHG2 DYNC1I1 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 TRIP10 SOS2 ITGB3BP RAB9A ARHGEF6 FGD1 RAB9B FGD2 FGD3 FGD4 PIK3R4 NCOA2 STAM2 S100A9 S100A8 FRS2 PIK3C3 PPP2R1B PPP2R5E PPP2R5B RHOT1 PPP2R5A PPP2R5D PPP2R5C YWHAQ YWHAH PPP2CA PPP2CB PDPK1 ALS2 PLIN3 MYH9 ZNF512B CLTC WASL PIK3R1 IQGAP1 SH3RF1 ARHGAP12 CDC42 PAK1 NCK2 PAK6 WDR6 CALM1 CEP97 SPTAN1 DYNLL2 GIT1 SPTBN1 NCK1 GIT2 TPM4 DST USP9X TPM3 TXNL1 VHL MYO9A VANGL1 DEPDC1B PEAK1 DLG5 RHOV ARHGEF7 EPHA2 YWHAB XPO1 PRKCD PRKCA YWHAZ LMNB1 AURKB MAPK14 MAPK11 CDKN1B CCNE1 BTK RHOC RHOB STEAP3 FLOT1 CKB BUB1B BUB3 MAD2L1 SPEN RNF20 CCT2 CPSF7 ROCK1 ROCK2 CUL3 BIRC5 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 CYFIP2 MYO6 PDE5A RBBP6 VIM HNRNPC WIPF1 CCT7 WIPF2 MTR RBMX DBN1 WIPF3 DBT RASAL2 RAC2 ARAP1 ARMCX3 CDC42EP4 PIK3R3 PLD2 ARHGEF18 SAMM50 MTX1 PRKCZ DEF6 RHOA PARD6A MTMR1 SOWAHC DEFECTIVE ABCA12 CAUSES ARCI4B%REACTOME DATABASE ID RELEASE 76%5682294 Defective ABCA12 causes ARCI4B ABCA12 AMINO ACIDS REGULATE MTORC1%REACTOME DATABASE ID RELEASE 76%9639288 Amino acids regulate mTORC1 TCIRG1 ATP6V1G3 ATP6V0E2 ATP6V1H ATP6V1A SESN2 ATP6V1D ATP6V1F SEC13 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 FLCN SESN1 C12orf66 SZT2 MIOS ATP6V1B2 ITFG2 ATP6V1B1 KPTN ATP6V0D1 DEPDC5 ATP6V0D2 SEH1L NPRL2 NPRL3 WDR24 SH3BP4 FNIP1 FNIP2 WDR59 CASTOR1 CASTOR2 BMT2 ATP6V1C1 RPTOR ATP6V1C2 MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 ATP6V0B LAMTOR3 LAMTOR5 ATP6V0C METABOLISM OF FOLATE AND PTERINES%REACTOME DATABASE ID RELEASE 76%196757 Metabolism of folate and pterines DHFR2 SLC46A1 ALDH1L1 MTHFR MTHFS ALDH1L2 DHFR MTHFD1L MTHFD1 MTHFD2 MTHFD2L SLC25A32 FOLR2 SLC19A1 SHMT2 SHMT1 REACTIONS SPECIFIC TO THE HYBRID N-GLYCAN SYNTHESIS PATHWAY%REACTOME%R-HSA-975574.1 Reactions specific to the hybrid N-glycan synthesis pathway MGAT3 GSD 0 (MUSCLE)%REACTOME DATABASE ID RELEASE 76%3828062 GSD 0 (muscle) GYG1 GYS1 PROGRAMMED CELL DEATH%REACTOME%R-HSA-5357801.2 Programmed Cell Death GSDMD PPP3R1 SDCBP IL18 MAPK1 IL1A IL1B MAPK3 KPNA1 HSP90AA1 CDC37 YWHAE KPNB1 GSN DSG2 YWHAG UNC5A UNC5B DYNLL1 ADD1 UBA52 UBB TFDP1 UBC TFDP2 RPS27A CDH1 E2F1 BCL2L11 IRF1 IRF2 ELANE CTNNB1 GSDME CASP3 UL36 NS MAGED1 STUB1 CRMA SPI-2 DCC PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 C1QBP OPA1 PSMD5 PSMD2 BCL2 PSMD3 BCL2L1 PSMD1 PSMA5 PSMA6 ARHGAP10 PSMA3 TJP1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BIRC2 PSMD10 BIRC3 PSMB11 PSMD12 PSMD11 XIAP PSMD14 PSMD13 OMA1 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 BAD PSMB4 PSMB5 PSMB2 PSMB3 APC PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 AVEN PSMC5 CASP9 PSMC6 CASP7 PPP3CC PSMC3 CHMP4C PSMC4 CHMP4B DIABLO PSMC1 UACA CARD8 PSMC2 NMT1 CHMP4A TP63 TP53BP2 CASP8 TRADD RIPK1 TRAF2 FADD CHMP2B CHMP2A TP73 PPP1R13B YWHAQ YWHAH CHMP3 CHMP6 CHMP7 RIPK3 MAPK8 SPTAN1 BMF DYNLL2 CLSPN OGT STAT3 YWHAB TNFSF10 AKT1 FLOT2 TNFRSF10B TNFRSF10A DSP PRKCD PTK2 YWHAZ LMNB1 DSG1 PRKCQ AKT3 TP53 3a CDKN2A BBC3 BCAP31 TJP2 HMGB1 BID SFN CASP5 CASP4 FLOT1 PDCD6IP RIR1 PELI1 BAK1 MLKL GZMB PMAIP1 CYCS MC159L ORF71 TICAM2 LY96 FASLG CASP6 TICAM1 CASP1 FAS APAF1 CD14 TLR4 ROCK1 BAX AKT2 VIM APIP DAPK1 DAPK2 DAPK3 H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 OCLN APPL1 DFFB DFFA DBNL GAS2 MAPT SATB1 FNTA PLEC PKP1 BMX STK24 STK26 HMGB2 DNM1L DSG3 ACIN1 PROSTANOID LIGAND RECEPTORS%REACTOME%R-HSA-391908.1 Prostanoid ligand receptors PTGDR2 TBXA2R PTGDR PTGFR PTGER1 PTGIR PTGER2 PTGER3 PTGER4 TFAP2A ACTS AS A TRANSCRIPTIONAL REPRESSOR DURING RETINOIC ACID INDUCED CELL DIFFERENTIATION%REACTOME%R-HSA-8869496.2 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation NPM1 NOP2 HSPD1 TFAP2A MYBL2 SMOOTH MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 76%445355 Smooth Muscle Contraction DYSF MYL6B TPM4 MYL6 ACTG2 MYH11 CALD1 MYL9 ANXA6 TPM3 MYLK MYL10 ANXA2 CAV3 GUCY1A2 TPM2 GUCY1A1 TPM1 SORBS1 SORBS3 PXN MYLPF ACTA2 MYL5 MYL7 MYL12A TLN1 VCL MYL12B PAK2 ITGA1 PAK1 ANXA1 CALM1 GUCY1B2 TRIM72 GUCY1B1 ITGB5 LMOD1 PIWI-INTERACTING RNA (PIRNA) BIOGENESIS%REACTOME%R-HSA-5601884.1 PIWI-interacting RNA (piRNA) biogenesis PIWIL2 TDRKH PIWIL1 PIWIL4 PLD6 POLR2A HENMT1 POLR2B POLR2C ASZ1 POLR2D MAEL POLR2E MOV10L1 DDX4 POLR2F MYBL1 POLR2G TDRD9 POLR2H TDRD6 POLR2I TDRD1 POLR2J TDRD12 POLR2K FKBP6 POLR2L HSP90AA1 ESTROGEN-STIMULATED SIGNALING THROUGH PRKCZ%REACTOME DATABASE ID RELEASE 76%9634635 Estrogen-stimulated signaling through PRKCZ HRAS MAPK1 PRKCZ PDPK1 NRAS LTC4-CYSLTR MEDIATED IL4 PRODUCTION%REACTOME DATABASE ID RELEASE 76%9664535 LTC4-CYSLTR mediated IL4 production DPEP2 DPEP1 DPEP3 CYSLTR1 CYSLTR2 GGT5 GGT1 REDUCTION OF CYTOSOLIC CA++ LEVELS%REACTOME%R-HSA-418359.1 Reduction of cytosolic Ca++ levels ATP2A1 SLC8A3 SLC8A1 SLC8A2 ATP2B4 CALM1 ATP2B3 ATP2B2 ATP2A3 ATP2B1 SRI ATP2A2 DOWNSTREAM SIGNAL TRANSDUCTION%REACTOME%R-HSA-186763.2 Downstream signal transduction CRK PIK3CA PLCG1 SOS1 STAT6 BCAR1 GRB7 STAT3 PDGFB CRKL STAT5A PDGFRB STAT5B STAT1 HRAS PDGFRA PIK3CB RASA1 NRAS PTPN11 PIK3R1 RAPGEF1 NCK2 SRC PIK3R2 NCK1 CARNITINE METABOLISM%REACTOME%R-HSA-200425.5 Carnitine metabolism CPT2 MID1IP1 CPT1A THRSP PRKAB2 SLC25A20 PRKAA2 CPT1B PPARD RXRA PRKAG2 SLC22A5 RNA POLYMERASE I PROMOTER CLEARANCE%REACTOME DATABASE ID RELEASE 76%73854 RNA Polymerase I Promoter Clearance CCNH POLR2E POLR2F POLR2H MAPK3 H2AX EHMT2 H2AB1 POLR2K H2AC19 POLR2L CHD4 CHD3 GTF2H1 TTF1 GTF2H2 H2AC14 H2BC21 GTF2H3 GTF2H4 H2BU1 H3-3B GTF2H5 H3C8 CDK7 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 TAF1D H3C15 MTA1 TAF1B RBBP4 TAF1C TAF1A H2BS1 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 GATAD2B GATAD2A H2AC20 ERCC6 MBD2 RRN3 UBTF TOXICITY OF BOTULINUM TOXIN TYPE F (BOTF)%REACTOME%R-HSA-5250981.2 Toxicity of botulinum toxin type F (botF) botF SV2C SV2B SV2A VAMP1 VAMP2 CD28 DEPENDENT VAV1 PATHWAY%REACTOME%R-HSA-389359.1 CD28 dependent Vav1 pathway CD80 CD28 RAC1 FYN PAK2 CDC42 PAK3 PAK1 VAV1 CD86 LCK TRANSCRIPTIONAL REGULATION OF GRANULOPOIESIS%REACTOME DATABASE ID RELEASE 76%9616222 Transcriptional regulation of granulopoiesis CBFB RUNX1 CDK2 RXRA RARA H2AX H2AB1 H2AC19 H2AC14 H2BC21 MYB EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 CEBPB H2BC17 CSF3R H2BC12 SPI1 H2BC13 GFI1 H2BC14 TAL1 H2AJ CEBPA KMT2A IL6R H2BC15 CEBPE FLI1 KLF5 H2BC11 GATA2 H3C15 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 STAT3 H2BC3 H2BC1 DEK H2AC20 TFDP1 TFDP2 CDK4 E2F1 CREB1 MYC CDKN1A LEF1 RRNA PROCESSING IN THE MITOCHONDRION%REACTOME%R-HSA-8868766.2 rRNA processing in the mitochondrion HSD17B10 NSUN4 TRMT10C MTERF4 PRORP TFB1M ELAC2 MRM1 MRM2 MRM3 DEFECTIVE MTR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLG%REACTOME DATABASE ID RELEASE 76%3359469 Defective MTR causes methylmalonic aciduria and homocystinuria type cblG MTRR MTR HSF1 ACTIVATION%REACTOME%R-HSA-3371511.1 HSF1 activation EEF1A1 HSBP1 HSF1 PTGES3 HDAC6 HSP90AA1 RPA1 RPA2 YWHAE RPA3 VCP HSP90AB1 SARS-COV INFECTIONS%REACTOME DATABASE ID RELEASE 76%9679506 SARS-CoV Infections GSK3A RIPK1 ITGB1 CHMP2B ATP1B3 CHMP2A ATP1B2 ATP1B1 ST6GALNAC2 RPN2 PRKCSH TUSC3 RPN1 MAGT1 FUT8 GANAB S MAN2A1 KDM1A MGAT5 ST3GAL4 HSP90AA1 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST MGAT4C DAD1 FXYD4 MGAT4A CHMP3 MGAT4B FXYD3 CANX FXYD2 STT3A FXYD1 MAN1B1 FXYD7 CHMP6 ST6GALNAC3 CHMP7 ST6GALNAC4 FXYD6 PHF21A HSP90AB1 TUBB PTGES3 8b ZCRB1 DDX5 ATP1A4 VHL 9b ATP1A3 FKBP4 UVRAG ATP1A2 ATP1A1 S1PR1 ARID4B GALNT1 SAP30 PARP10 TYK2 PARP6 GSK3B SUDS3 PARP4 PARP16 UBA52 PARP9 PARP14 N RCOR1 PARP8 BECN1 ZBP1 COMT UBB SAP30L RB1 SAP18 UBC RPS27A HMG20B JAK2 ITGA4 UBE2I NR3C1 ACE2 ST3GAL3 TMPRSS2 7a 3a SUMO1 CTSL CHD4 CHD3 M MAP1LC3B TBK1 AP2A1 ARID4A AP2A2 NS5B JAK3 IL6R IL1R1 SIGMAR1 BRMS1 IFNGR1 FURIN AP2M1 IFNGR2 TLR7 IFNAR1 JAK1 BRD4 CRBN STAT2 REST HDAC2 IMPDH1 HDAC1 IMPDH2 PDCD1 MTA1 RBBP4 VCP RBBP7 MTA2 ROCK1 ROCK2 MTA3 MBD3 CYSLTR1 AP2S1 E 1a rep GATAD2B GATAD2A AP2B1 PIK3R4 CHMP4C CHMP4B CHMP4A TLR9 PIK3C3 FKBP1A AMPK INHIBITS CHREBP TRANSCRIPTIONAL ACTIVATION ACTIVITY%REACTOME%R-HSA-163680.3 AMPK inhibits chREBP transcriptional activation activity STK11 PRKAB2 MLXIPL PRKAA2 ADIPOQ ADIPOR1 PRKAG2 ADIPOR2 TWIK-RELATED SPINAL CORD K+ CHANNEL (TRESK)%REACTOME DATABASE ID RELEASE 76%1299344 TWIK-related spinal cord K+ channel (TRESK) KCNK18 NIK-->NONCANONICAL NF-KB SIGNALING%REACTOME DATABASE ID RELEASE 76%5676590 NIK-->noncanonical NF-kB signaling BTRC SKP1 PSMD8 PSMD9 PSMD6 FBXW11 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RELB PSMA2 UBA3 PSME3 MAP3K14 PSME4 UBE2M PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 CHUK UBC PSMB8 PSMB9 RPS27A SEM1 NFKB2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PROCESSING OF CAPPED INTRON-CONTAINING PRE-MRNA%REACTOME%R-HSA-72203.3 Processing of Capped Intron-Containing Pre-mRNA PABPN1 CPSF4 ZCRB1 DDX5 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 SNRPD3 SRRM2 METTL3 CRNKL1 CD2BP2 SF1 SLBP CSTF3 SNU13 NCBP1 RNPC3 PCBP1 NCBP2 CSTF1 SYMPK ZRSR2 PRPF38A HNRNPL HNRNPM HNRNPK HNRNPF SUGP1 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SRSF10 SF3A3 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CWC27 EFTUD2 CWC22 PAPOLA MTREX TXNL4A SNRNP35 SNW1 SNRPN WBP11 PRPF4 PRPF6 HNRNPUL1 PRPF3 NXT1 EIF4A3 SNRPG CASC3 SNRNP27 GLE1 PPIH MAGOH SNRPE THOC1 SNRPF THOC3 SNRNP25 POLR2A THOC2 SNRPC POLR2B THOC5 SNRNP200 POLR2C CDC40 SNRPA POLR2D THOC7 SNRPB POLR2E THOC6 PRPF8 POLR2F DDX39A ZMAT5 POLR2G DDX39B FUS POLR2H ZC3H11A CPSF3 POLR2I SARNP CPSF2 POLR2J SRSF2 CWC15 POLR2K SRSF3 LSM5 POLR2L SRSF4 LSM4 SRSF5 LSM3 SRSF6 LSM2 SRSF7 CHERP SLU7 GTF2F1 LSM8 SRSF9 LSM7 FYTTD1 LSM6 GTF2F2 DDX46 LUZP4 RBM8A DDX42 PPWD1 POLDIP3 YBX1 SRSF1 USP39 U2AF1 ELAVL2 U2AF1L4 PTBP1 NXF1 PCBP2 SEC13 SART1 U2AF2 DHX38 METTL14 SRSF11 SNRNP70 CHTOP RBM5 ALYREF BCAS2 UPF3B CTNNBL1 MAGOHB RBM17 NXF2B BUD31 RNPS1 TFIP11 PLRG1 NUP107 SYF2 NUP188 SNRPA1 DNAJC8 RBM22 WBP4 DDX23 PRCC CSTF2T PUF60 FIP1L1 SNRPB2 HNRNPA1 SMNDC1 NUP210 HNRNPA0 HNRNPA3 PPIL1 NUP93 WTAP GPKOW CDC5L POM121 U2SURP NUP205 SNRNP40 SF3B1 SNRNP48 PPIL3 PPIL4 PPIL6 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 ISY1 PRPF19 AQR PPIE NUP62 NDC1 XAB2 NUP133 NUP50 NUP54 CLP1 CSTF2 NUP42 NUP43 RAE1 CPSF1 RANBP2 NUP35 NUP37 HSPA8 DHX9 ELAVL1 NUP214 CPSF7 SRRM1 TRA2B HNRNPC EIF4E RBMX HEPARAN SULFATE HEPARIN (HS-GAG) METABOLISM%REACTOME DATABASE ID RELEASE 76%1638091 Heparan sulfate heparin (HS-GAG) metabolism GPC5 GPC4 HS3ST3A1 HS6ST1 GPC6 HS6ST2 HS2ST1 HS6ST3 B3GAT3 NDST2 NDST1 NDST4 NDST3 B3GALT6 HS3ST3B1 EXT1 GLCE EXT2 HS3ST5 HS3ST6 SDC1 HS3ST4 HS3ST1 AGRN B4GALT7 HS3ST2 DCN SLC35D2 NCAN BGN VCAN GLB1 NAGLU CSPG5 CSPG4 HPSE2 XYLT2 XYLT1 SGSH IDS GUSB IDUA B3GAT2 B3GAT1 GLB1L HPSE HSPG2 BCAN SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 PECAM1 INTERACTIONS%REACTOME%R-HSA-210990.1 PECAM1 interactions ITGAV PECAM1 FYN PTPN6 PLCG1 INPP5D PTPN11 LYN ITGB3 YES1 LCK IKBKB DEFICIENCY CAUSES SCID%REACTOME DATABASE ID RELEASE 76%5602636 IKBKB deficiency causes SCID IKBKB CHUK IKBKG DEFECTIVE B3GAT3 CAUSES JDSSDHD%REACTOME DATABASE ID RELEASE 76%3560801 Defective B3GAT3 causes JDSSDHD GPC5 GPC4 CSPG5 GPC6 CSPG4 B3GAT3 DCN SDC1 AGRN HSPG2 SDC4 BCAN SDC2 SDC3 NCAN BGN GPC1 VCAN GPC3 GPC2 BINDING OF TCF LEF:CTNNB1 TO TARGET GENE PROMOTERS%REACTOME%R-HSA-4411364.3 Binding of TCF LEF:CTNNB1 to target gene promoters MYC TCF7L2 AXIN2 TCF7L1 RUNX3 CTNNB1 TCF7 LEF1 TOLL LIKE RECEPTOR TLR1:TLR2 CASCADE%REACTOME%R-HSA-168179.1 Toll Like Receptor TLR1:TLR2 Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN RPS27A CREB1 MAPK14 MAPK11 ATF2 FOS S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 PELI1 SOCS1 IRAK4 SAA1 MYD88 LY96 FGB FGA CD14 TLR4 FGG ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 REGULATION OF TP53 DEGRADATION%REACTOME%R-HSA-6804757.1 Regulation of TP53 Degradation CCNA1 PPP2R1B TP53 MAPKAP1 CDKN2A CDK2 MDM2 ATM MDM4 PPP2R5C UBA52 PRR5 AKT2 MLST8 AKT1 USP2 PPP2CA PPP2CB UBB MTOR UBC RPS27A PDPK1 DAXX USP7 SGK1 RNF34 PPP2R1A RICTOR RFFL CDK1 CCNG1 PHF20 CHEK2 AKT3 CCNA2 TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES%REACTOME%R-HSA-425393.2 Transport of inorganic cations anions and amino acids oligopeptides SLC8A1 SLC20A1 SLC3A2 SLC8A2 SLC43A1 SLC3A1 SLC12A3 SLC4A2 SLC12A1 SLC4A3 SLC36A4 SLC4A5 SLC24A2 SLC24A1 SLC24A4 SLC24A3 SRI SLC8B1 SLC1A2 SLC1A4 SLC1A6 SLC1A7 SLC16A10 SLC6A6 SLC8A3 CALM1 SLC1A5 SLC7A6 SLC7A8 SLC7A1 SLC7A3 SLC6A12 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC4A7 SLC9A9 SLC9A1 SLC4A8 SLC4A9 SLC26A11 SLC15A1 SLC38A1 SLC5A5 SLC15A2 SLC26A1 SLC15A3 SLC38A3 SLC15A4 SLC38A2 SLC26A2 SLC38A5 SLC38A4 SLC4A10 SLC26A7 SLC26A9 SLC26A6 SLC36A1 SLC7A5 SLC5A12 SLC25A26 SLC25A29 SLC6A20 SLC12A2 SLC12A4 SLC12A5 CTNS AHCYL2 SLC12A7 SLC4A1 SLC4A4 SLC12A6 SLC6A15 SLC34A3 SLC34A2 SLC6A19 SLC6A18 SLC6A14 SLC1A1 SLC1A3 SLC26A4 SLC26A3 SLC7A11 SLC34A1 SLC7A10 SLC32A1 SLC25A10 SLC5A8 SLC36A2 SLC25A18 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC7A7 SLC17A1 SLC7A9 SLC25A22 SLC20A2 SLC43A2 CYSTEINE FORMATION FROM HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 76%1614603 Cysteine formation from homocysteine CTH CBSL CBS RHO GTPASE CYCLE%REACTOME%R-HSA-9012999.1 RHO GTPase cycle FAM169A TOR1AIP1 AKAP12 BAIAP2L2 BASP1 POTEE FARP1 ACTN1 RHOF SENP1 DIAPH1 DIAPH2 PAK3 TWF1 WAS HSP90AA1 DOCK11 CDC37 ERBIN HGS CCP110 RAB7A MYO9B FARP2 PLXND1 DOCK6 DOCK5 DOCK4 DOCK3 PLXNA1 DOCK9 SRGAP3 DOCK8 SRGAP1 DOCK7 CAPZB RAC1 WASF3 DOCK2 DOCK1 LCK RASGRF2 GRB7 ACTB PREX2 WWP2 PAK5 ARHGAP10 VCP RND1 AAAS PAK2 UACA STMN2 WDR91 EPSTI1 ANKFY1 STARD8 FRS3 WDR81 DAAM1 IQGAP3 ANKLE2 STARD13 ARHGDIG JUP ARHGDIA FAM135A MCF2L CDC42SE2 VAV3 ARHGAP9 PLEKHG3 ARHGAP8 ARHGEF16 OSBPL11 RHOG ARHGAP4 VAV1 LRRC1 NDUFS3 ELMO2 NUDC ARHGEF5 RRAS2 ARHGEF26 SHMT2 GMIP PLD1 IQGAP2 CIT CDC42EP5 KALRN HMOX2 NDUFA5 CDC42EP3 CCT6A HSPE1 CDC42EP2 LETM1 PKN3 VAPB MAP3K11 FGD5 CHN2 CHN1 KIDINS220 WDR11 TMEM59 TUBA1B SHKBP1 GOPC PKN2 FILIP1 PKN1 HSP90AB1 STIP1 UHRF1BP1L FAM13B FAM13A MSI2 STK10 SLK GOLGA8R RALGAPA1 FAM91A1 TEX2 PHIP RHOBTB2 DDRGK1 NSFL1C ARHGAP11A ARHGAP11B TAGAP EFHD2 PLEKHG4 DDX4 ARHGEF28 PLEKHG1 TNFAIP1 PLEKHG6 ACTG1 RND3 FLOT2 NIPSNAP2 MUC13 FAM83B DSP ANKRD26 PLEKHG5 SH3BP1 CSK TMOD3 WHAMM SEMA4F SCRIB PCDH7 PTPN13 CDC42BPB CKAP4 KTN1 CDC42BPA NISCH CCDC88A VANGL2 CPNE8 GOLGA3 UBXN11 CPD SPATA13 KCTD13 DSG1 PKP4 TMEM87A PICALM ANLN ITSN1 FAF2 FNBP1L KIF14 HINT2 GJA1 SH3PXD2A CCDC115 RHOH RHOD RHOJ RHOU PLEKHG4B EMC3 FNBP1 PIK3CA BCAP31 CAVIN1 SOS1 DLC1 TJP2 RTKN PRAG1 SYDE2 ARHGAP44 ARHGAP40 RALBP1 KCTD3 ARHGAP45 ALDH3A2 ARHGEF25 ARHGAP19 ARHGAP18 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 ARHGAP30 DNMBP RND2 ZAP70 GFOD1 CCDC187 MOSPD2 FMNL3 FMNL1 FMNL2 ACTC1 STX5 LAMTOR1 GNA13 ITGB1 CYFIP1 NCKAP1 TRIO TFRC NCF1 NCF2 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARHGAP6 ARHGAP35 DOCK10 PREX1 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 LBR EMD TMPO SWAP70 ARAP2 ARAP3 CYBB CYBA OCRL VRK2 LEMD3 VAV2 BCR ARFGAP3 TIAM1 ABCD3 RAPGEF1 CDC42EP1 DSG2 VAMP3 ARFGAP2 GARRE1 AMIGO2 NOXO1 ARHGAP17 PIK3R2 ATP6AP1 SLC1A5 ARHGAP15 LMAN1 ARHGAP21 ABR PGRMC2 RACGAP1 SLITRK3 NHS SLITRK5 ABL2 NCKAP1L WASF1 ADD3 SRGAP2 WASF2 YKT6 PAK4 IL32 JAG1 CAV1 MCAM MCF2 STOM BAIAP2 ARHGAP26 MPP7 ARHGAP32 SLC4A7 DIAPH3 ABI2 TAOK3 ABI1 NOXA1 NOX3 ESYT1 NOX1 FERMT2 ARL13B CFTR SCFD1 STAM ARHGEF40 DDX39B TIAM2 OBSCN NGEF ECT2 ARHGEF39 RHOQ NET1 ARHGEF10L AKAP13 C1QBP ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 TRIP10 SOS2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 STAM2 FRS2 ALS2 ZNF512B CLTC WASL PIK3R1 IQGAP1 SH3RF1 ARHGAP12 CDC42 PAK1 NCK2 PAK6 WDR6 CEP97 SPTAN1 GIT1 SPTBN1 NCK1 GIT2 TPM4 DST USP9X TPM3 TXNL1 MYO9A VANGL1 DEPDC1B PEAK1 DLG5 RHOV ARHGEF7 EPHA2 LMNB1 RHOC RHOB STEAP3 FLOT1 CKB SPEN RNF20 CCT2 CPSF7 ROCK1 ROCK2 CUL3 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 CYFIP2 MYO6 PDE5A RBBP6 VIM HNRNPC WIPF1 CCT7 WIPF2 MTR RBMX DBN1 WIPF3 DBT RASAL2 RAC2 ARAP1 ARMCX3 CDC42EP4 PIK3R3 PLD2 ARHGEF18 SAMM50 MTX1 DEF6 RHOA PARD6A MTMR1 SOWAHC RPIA DEFICIENCY: FAILED CONVERSION OF RU5P TO R5P%REACTOME DATABASE ID RELEASE 76%6791461 RPIA deficiency: failed conversion of RU5P to R5P RPIA CONSTITUTIVE SIGNALING BY AKT1 E17K IN CANCER%REACTOME%R-HSA-5674400.1 Constitutive Signaling by AKT1 E17K in Cancer FOXO3 MAPKAP1 MDM2 GSK3A GSK3B FOXO1 PRR5 AKT2 MLST8 AKT1 BAD TSC2 MTOR CHUK CASP9 PDPK1 AKT1S1 FOXO6 NR4A1 RPS6KB2 CREB1 RICTOR CDKN1A CDKN1B FOXO4 AKT3 RNA POLYMERASE III CHAIN ELONGATION%REACTOME%R-HSA-73780.2 RNA Polymerase III Chain Elongation POLR3K POLR2L CRCP POLR3GL POLR3A POLR3B POLR2E POLR3C POLR1C POLR2F POLR3D POLR3E POLR1D POLR2H POLR3F POLR3G POLR3H POLR2K SUMOYLATION OF DNA REPLICATION PROTEINS%REACTOME%R-HSA-4615885.3 SUMOylation of DNA replication proteins NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 SUMO1 NUP205 SUMO3 CDCA8 SUMO2 NUP35 PCNA BIRC5 NUP37 TOP2A AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 AURKA RANGAP1 NUP214 NUP153 INCENP AURKB TOP2B SEC13 NUP62 TOP1 NDC1 NUP133 NUP107 NUP188 PIAS4 NUP50 PIAS3 NUP54 UBE2I DEFECTIVE CYP26B1 CAUSES RHFCA%REACTOME%R-HSA-5579015.2 Defective CYP26B1 causes RHFCA CYP26B1 PKA-MEDIATED PHOSPHORYLATION OF CREB%REACTOME DATABASE ID RELEASE 76%111931 PKA-mediated phosphorylation of CREB PRKX PRKAR2B NBEA ADCY4 PRKACG ADCY3 PRKACB ADCY2 ADCY1 CREB1 ADCY8 ADCY7 ADCY6 ADCY9 ADCY5 PRKAR1B PRKAR1A PRKACA PRKAR2A CALM1 DEFECTIVE SLC4A1 CAUSES HEREDITARY SPHEROCYTOSIS TYPE 4 (HSP4), DISTAL RENAL TUBULAR ACIDOSIS (DRTA) AND DRTA WITH HEMOLYTIC ANEMIA (DRTA-HA)%REACTOME%R-HSA-5619050.1 Defective SLC4A1 causes hereditary spherocytosis type 4 (HSP4), distal renal tubular acidosis (dRTA) and dRTA with hemolytic anemia (dRTA-HA) SLC4A1 BIOLOGICAL OXIDATIONS%REACTOME DATABASE ID RELEASE 76%211859 Biological oxidations GSTZ1 TPST2 TPST1 CYP26A1 CYP27B1 CYP11B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 CYP2C9 CYP2C8 CYP2D6 CYP1A2 CYP2E1 CYP3A4 CHAC1 GGT1 DPEP2 DPEP1 DPEP3 POMC GGT5 RXRA N6AMT1 TRMT112 CES3 NCOA1 NCOA2 ACSM5 ACSM4 AS3MT FDXR CYP1B1 CHAC2 SULT2A1 GSTK1 CMBL POR CYP2U1 FDX1 FDX2 CES2 CES1 MAOB MTARC2 MTARC1 MGST3 MGST1 MGST2 ADH7 ADH5 ADH6 SULT1A1 ADH4 CYB5R3 CYP2B6 GSTT2B SULT1A4 SULT1A3 SULT1A2 ACSM1 GSTM4 GSTM3 ACSM2B GLYATL3 GSTM2 GLYATL2 GSTM1 GLYATL1 CYP4F2 CYP4F3 CYP4F8 SULT1B1 CYP2S1 CYP1A1 GSTM5 ACY3 ACY1 SULT1C2 SULT1C4 GSTO2 GSTO1 AKR1A1 UGDH CYP21A2 AHRR ADH1C ADH1B ADH1A GSTP1 PTGS1 SULT1E1 CYP2A13 CYP2F1 CBR3 AOC3 ARNT2 SLC35B3 NQO2 SLC35B2 AOC1 AOC2 GSS FMO1 SLC35D1 FMO2 CYP2W1 GSTA5 GSTA4 AADAC GSTA3 HSP90AB1 GSTA2 MTRR GSTA1 GGT3P PTGES3 UGT1A10 TPMT AHR CNDP2 AKR7A2 ABHD10 HPGDS AKR7A3 UGT2B10 UGT2B11 UGT2B15 AIP UGT2B17 ALDH3A1 SULT6B1 GSTT2 GSTT1 GLYAT CYP4F22 CYP2C19 CYP2C18 CYP19A1 CYP11A1 ESD UGT3A2 MAOA UGT3A1 COMT CYP2J2 GGT7 GGT6 EPHX1 CYP4F11 MAT2B CYP4F12 GGCT GCLC NAT1 NAT2 CYP11B2 TBXAS1 GCLM PODXL2 CYP4A22 ACSM2A SLC26A1 OPLAH ALDH2 CYP4V2 UGT2A3 UGT2A2 UGT2A1 FMO3 SULT4A1 UGT1A1 SLC26A2 CYP4A11 CYP3A43 ARNT ABHD14B CYP2A7 CYP2A6 ALDH1A1 UGT2B4 PAPSS2 UGT2B7 ACSS2 UGT2B28 CYP3A5 BPHL CYP3A7 UGP2 MAT2A ALDH1B1 UGT1A5 UGT1A4 BPNT2 BPNT1 UGT1A3 UGT1A9 CYP51A1 ACSS1 UGT1A8 UGT1A7 UGT1A6 CYB5B CYP4B1 AKR7L AHCY CYP46A1 PAPSS1 CYP7A1 PTGIS NR1H4 CYP7B1 CYP8B1 CYP27A1 CYP39A1 MAT1A NNMT MTR PAOX SEMA4D IN SEMAPHORIN SIGNALING%REACTOME DATABASE ID RELEASE 76%400685 Sema4D in semaphorin signaling SEMA4D LIMK2 LIMK1 MYL6 MYH14 MYH11 ARHGEF11 MYL9 MYH10 ERBB2 ARHGEF12 MYH9 ROCK1 ROCK2 RND1 RAC1 RHOC MYL12B RHOB RRAS MET PLXNB1 RHOA ARHGAP35 PEXIDARTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702605.1 pexidartinib-resistant FLT3 mutants FLT3 COMPETING ENDOGENOUS RNAS (CERNAS) REGULATE PTEN TRANSLATION%REACTOME DATABASE ID RELEASE 76%8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation TNRC6A AGO3 TNRC6B AGO4 AGO1 AGO2 TNRC6C MOV10 ACTIVATED NTRK2 SIGNALS THROUGH RAS%REACTOME DATABASE ID RELEASE 76%9026519 Activated NTRK2 signals through RAS NTF4 BDNF HRAS SOS1 NRAS NTRK2 ARL13B-MEDIATED CILIARY TRAFFICKING OF INPP5E%REACTOME DATABASE ID RELEASE 76%5624958 ARL13B-mediated ciliary trafficking of INPP5E ARL13B INPP5E PDE6D POTASSIUM CHANNELS%REACTOME%R-HSA-1296071.2 Potassium Channels KCNJ11 KCNMA1 KCNQ4 GNG10 GNG12 GNG11 KCNMB1 GNG13 KCNMB2 KCNMB3 GNB2 KCNMB4 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 GNG2 KCNK18 GNG5 GNG4 GNG7 GNG8 KCNQ2 KCNQ3 KCNG1 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNH3 KCNH4 KCNH5 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNN1 KCNN3 KCNN4 KCNF1 KCNK6 KCNK7 KCNC1 KCNK9 KCNC2 KCNC3 KCNN2 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNA6 KCNA7 KCNJ1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ10 KCNJ8 KCNB1 KCNJ9 KCNJ12 KCNB2 KCNJ14 KCNJ15 KCNJ16 KCNS1 KCNS2 KCNS3 KCNK1 KCNK2 HCN2 KCNK3 GABBR2 KCNK4 HCN1 GABBR1 ABCC8 ABCC9 AFLATOXIN ACTIVATION AND DETOXIFICATION%REACTOME%R-HSA-5423646.4 Aflatoxin activation and detoxification ACY1 DPEP2 DPEP1 GGT3P MGST3 DPEP3 MGST1 MGST2 AKR7A2 AKR7A3 CYP2A13 AKR7L CYP1A2 CYP3A4 GGT5 GGT1 GGT7 GGT6 ACY3 CYP3A5 INTERLEUKIN-20 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 76%8854691 Interleukin-20 family signaling STAT4 TYK2 STAT3 IL22 IL20 IL26 IL24 IL20RA IL20RB IL22RA2 IFNL2 STAT5A IFNL1 STAT5B STAT1 IFNL3 IL10RB IL19 IFNLR1 IL22RA1 PTPN11 JAK2 JAK3 JAK1 STAT2 SIGNALING BY FGFR2 AMPLIFICATION MUTANTS%REACTOME%R-HSA-2023837.1 Signaling by FGFR2 amplification mutants FGFR2 NEF AND SIGNAL TRANSDUCTION%REACTOME%R-HSA-164944.2 Nef and signal transduction RAC1 FYN DOCK2 PAK2 ELMO1 HCK nef LCK PHYSIOLOGICAL FACTORS%REACTOME%R-HSA-5578768.1 Physiological factors CORIN WWTR1 KAT2B HIPK1 GATA4 NPPC NPR1 HIPK2 NPR2 NPPA TBX5 NKX2-5 MAP3K8 (TPL2)-DEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-5684264.2 MAP3K8 (TPL2)-dependent MAPK1 3 activation FBXW11 MAP2K4 UBB IKBKB CHUK TNIP2 UBC RPS27A IKBKG UBA52 MAP2K1 BTRC NFKB1 SKP1 CUL1 MAP3K8 DISEASES OF SIGNAL TRANSDUCTION BY GROWTH FACTOR RECEPTORS AND SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 76%5663202 Diseases of signal transduction by growth factor receptors and second messengers ATG7 CREBBP BRAP JAG2 FN1 FZD8 BRAF SHH NOX4 HHAT DHH GRB2 STRN IHH ZMYM2 FZD5 HEY1 GSK3A HEY2 FZD6 KREMEN1 DUSP16 AGTRAP KREMEN2 DUSP8 DUSP9 VCL CNKSR2 APBB1IP CNKSR1 MRAS KIT AMER1 FYN KANK1 NEURL1B MAPK1 LMNA SHOC2 AGK SYVN1 MIB2 MAPK3 MIB1 HEYL AGGF1 PDGFB PEBP1 PIM1 ARRB1 PDGFRB RNF43 ARRB2 STAT1 HGF HSP90AA1 CDC37 FAM114A2 PORCN ERBB2 ERBIN MARK3 CPSF6 WNT3A ESR2 QKI CDK8 PPP1CB FGFR3 FGFR1 TENT4A CD86 KIAA1549 PPP2R1A CD80 DUSP10 MYO18A KSR1 BCR KSR2 ETV6 ESRP1 KDM7A HDAC5 LRP5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 PIK3R2 LRP6 DLL4 HES5 TRAT1 FAM131B HDAC6 NEURL1 PIK3AP1 AKAP9 JAG1 ITGA2B UBA52 MAP2K1 MAP2K2 CLCN6 CUL1 NCBP1 NCBP2 UBB GOLGA4 UBC RPS27A MAML2 MAML1 ITGB3 RBPJ PIK3CD MYC RAC1 JAK2 ADAM10 ADAM17 MET EREG BTC MAML3 CEP43 NOTCH1 HDAC4 SRC PSEN1 FOXO3 BCL2L11 HES1 TCF7L2 NCSTN SMAD4 ESR1 TGFA SMAD3 SNW1 FLT3 CTNNB1 KRAS MAMLD1 LCK TLN1 CD28 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2F1 EP300 GTF2F2 PSEN2 APH1A BAG4 APH1B AP3B1 KAT2B KAT2A PSMD8 PSMD9 PSMD6 PSMD7 HDAC2 PSMD4 PSENEN CUX1 HDAC1 FIP1L1 PSMD5 PSMD2 PSMD3 BCL2L1 FGB PSMD1 FGA PSMA5 PSMA6 LRRFIP1 VWF PSMA3 VCP PSMA4 PSMA1 PSMA2 EPGN FGG PSME3 PSME4 SEL1L PSME1 PSME2 TRIP11 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 BAD PSMB4 ERLIN2 PSMB5 PSMB2 PSMB3 KLB APC PSMB1 IRS1 PHB PSMF1 CHUK PSMB8 IRS2 PSMB9 PIK3CB FGF1 SEM1 PSMC5 FGF2 CASP9 PTPN12 PSMC6 FGF3 PSMC3 FGF4 TBL1XR1 PSMC4 FGF6 FOXO6 PSMC1 FGF7 NR4A1 TBL1X PSMC2 FGF9 RAP1B RPS6KB2 RAP1A FGF20 RAF1 FGF23 FGF22 FLT3LG FRS2 GAB2 FGF16 FGF19 FGF18 FGFR4 SMAD2 FGF10 HDAC3 DERL2 PPP2R1B MAPKAP1 PPP2R5E ERLEC1 OS9 PPP2R5B PPP2R5A PPP2R5D PPP2R5C WDR48 PRR5 RHOG VAV1 PPP2CA PPP2CB MAP3K11 PDPK1 PTPN11 RICTOR PIK3R1 IQGAP1 CALM1 CBL SPTBN1 FOXO4 EGF GSK3B AXIN1 STAT3 YWHAB AKT1 LYN YES1 DUSP6 DUSP7 CAMK2B CSK CAMK2D KDR CAMK2A CAMK2G PPP1CC NCOR2 CREB1 NCOR1 CDKN1A CDKN1B AKT3 TRAK1 SHC1 GAB1 MDM2 PIK3CA PLCG1 SOS1 CTBP2 CTBP1 RBX1 PAPSS1 FZD4 CSNK1A1 AREG NRG1 NRG2 PTEN NRG3 NRG4 HBEGF FOXO1 EGFR AKT2 MLST8 SPRED3 TSC2 SPRED2 STAT5A SPRED1 STAT5B MTOR HRAS PDGFRA FGFR2 AKT1S1 NRAS NF1 HDAC10 RAC2 HDAC11 TNKS2 ARAF TNKS TGFB1 CCNC PIK3R3 MPRIP FGFR1OP2 TRIM24 DKK1 SND1 TGFBR1 DKK2 DKK4 TGFBR2 BIN2 FKBP1A ZC3HAV1 FXR1 CD19 PCP CE PATHWAY%REACTOME%R-HSA-4086400.2 PCP CE pathway PRKCB FZD8 FZD7 WNT11 FZD3 SMURF2 FZD5 FZD6 DAAM1 PFN1 FZD4 ARRB2 RAC3 CLTA CLTC AP2A1 CLTB AP2A2 AP2M1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PRKCG PSMD2 WNT5B PSMD3 ROR1 PSMD1 ROR2 PSMA5 PRICKLE1 PSMA6 WNT1 WNT4 PSMA3 FZD1 PSMA4 RYK PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 DVL1 UBA52 PSMD10 PSMB11 PSMD12 DVL3 PSMD11 AP2S1 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB AP2B1 PRKCA PSMB3 PSMB1 PSMF1 SCRIB UBC PSMB8 PSMB9 WNT5A RPS27A SEM1 PSMC5 PSMC6 VANGL2 PSMC3 PSMC4 PSMC1 PSMC2 RAC2 RAC1 SMURF1 RHOA DVL2 PARD6A PI3K CASCADE%REACTOME%R-HSA-109704.5 PI3K Cascade GAB1 PIK3CA FLT3 AKT2 KLB IRS1 PDE3B PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 FLT3LG FRS2 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 PIK3C3 FGFR4 PIK3R2 FGF10 N-GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-532668.2 N-glycan trimming in the ER and Calnexin Calreticulin cycle DERL1 DERL2 RNF5 OS9 VCP UBXN1 NGLY1 RNF139 SEL1L MLEC UGGT2 UGGT1 MARCHF6 UBA52 EDEM3 PDIA3 EDEM1 AMFR RNF103 PRKCSH TRIM13 CALR SYVN1 ENGASE GANAB UBB UBC RNF185 RPS27A EDEM2 MOGS PSMC1 CANX MAN1B1 RAD23B ORGANIC ANION TRANSPORT%REACTOME%R-HSA-561048.1 Organic anion transport SLC22A7 SLC22A6 SLC22A12 SLC22A11 SLC22A8 ENDOSOMAL VACUOLAR PATHWAY%REACTOME DATABASE ID RELEASE 76%1236977 Endosomal Vacuolar pathway LNPEP HLA-G HLA-E CTSS CTSL HLA-H B2M HLA-B HLA-A HLA-C HLA-F COMPLEMENT CASCADE%REACTOME DATABASE ID RELEASE 76%166658 Complement cascade V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 C3AR1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 C3 C5 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 FCN1 FCN2 IGHV4-34 FCN3 IGHV1-2 CD81 IGHV4-39 C4BPA C4BPB C4A IGKV2-29 MASP1 IGKV2-28 CPB2 IGLC3 CFH IGLC1 CFI IGLC2 C4B_2 V1-9 C2 V1-7 VTN V1-5 C6 V1-3 C7 C9 C8B IGKV3D-20 C8A C8G MBL2 CR2 IGKV2-30 CR1 IGHV2-70 CD46 IGHV2-5 C1QB IGHV3-48 CRP IGLV3-1 C1QA COLEC11 COLEC10 IGKV1-39 C1S IGKV1-33 C1R CPN2 CPN1 IGHV3-53 IGLC7 CFHR2 CFHR1 IGKV5-2 CFHR4 F2 IGLC6 CFHR3 CFHR5 C1QC ELANE PROS1 CD59 CD55 CLU SERPING1 IGHV3-23 IGLV2-8 IGKV1-16 C5AR2 IGKV1-17 C5AR1 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 CFD IGKV4-1 GZMM IGHV7-81 CFB V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 CD19 TACHYKININ RECEPTORS BIND TACHYKININS%REACTOME%R-HSA-380095.2 Tachykinin receptors bind tachykinins TACR2 TACR3 TACR1 TAC3 TAC1 KILLING MECHANISMS%REACTOME DATABASE ID RELEASE 76%9664420 Killing mechanisms RAC1 DVL1 JUN FZD7 DVL3 WNT5A MAPK8 NOXO1 NOXA1 DVL2 CYBA NOX1 DOPAMINE RECEPTORS%REACTOME%R-HSA-390651.2 Dopamine receptors DRD1 DRD2 DRD3 DRD4 DRD5 ROLE OF LAT2 NTAL LAB ON CALCIUM MOBILIZATION%REACTOME%R-HSA-2730905.2 Role of LAT2 NTAL LAB on calcium mobilization V1-20 IGHV3-53 IGLC7 IGKV2D-40 IGHV3-11 IGKV5-2 IGLC6 IGHV3-13 LAT2 PIK3CA IGHV1-46 IGHE SOS1 IGHV V5-4 V5-1 SYK FYN V5-6 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 PDPK1 V4-6 V4-2 V4-1 IGKV1-5 PIK3R1 IGLV V3-4 V3-3 V3-2 PIK3R2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN IGHV3-23 IGLV1-51 IGLV2-23 IGLV2-8 IGKV3-20 IGHV4-34 IGKV1-16 IGHV1-2 IGHV4-39 IGKV1-17 IGKV1-12 PIK3CB IGHV3-7 IGKV2-29 IGHV3-9 IGKV2-28 IGLC3 IGHV3-30 IGLC1 V2-17 IGLC2 IGHV3-33 V1-9 V1-7 V2-15 V1-5 V2-19 V1-3 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV3D-20 V1-11 IGKV2D-30 GAB2 IGKV2-30 V1-16 IGHV2-70 V1-13 IGHV2-5 IGHV1-69 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 HEREDITARY FRUCTOSE INTOLERANCE%REACTOME DATABASE ID RELEASE 76%5657560 Hereditary fructose intolerance ALDOB INCRETIN SYNTHESIS, SECRETION, AND INACTIVATION%REACTOME%R-HSA-400508.1 Incretin synthesis, secretion, and inactivation ISL1 GNG13 TCF7L2 GNAT3 FFAR4 GNB3 CTNNB1 PCSK1 CDX2 GPR119 DPP4 GCG SPCS3 FFAR1 SPCS2 SPCS1 LEP GIP SEC11A SEC11C GRP GATA4 PAX6 REGULATION OF TP53 EXPRESSION%REACTOME%R-HSA-6804754.1 Regulation of TP53 Expression PRDM1 TP53 SIGNALING BY ERBB2 IN CANCER%REACTOME DATABASE ID RELEASE 76%1227990 Signaling by ERBB2 in Cancer NRG1 HSP90AA1 NRG2 NRG3 CDC37 HRAS NRG4 ERBB2 ERBIN SHC1 GAB1 PTPN12 PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 HBEGF EGFR EREG BTC CLEAVAGE OF THE DAMAGED PURINE%REACTOME%R-HSA-110331.2 Cleavage of the damaged purine H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 MPG H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 NEIL3 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 APOPTOSIS INDUCED DNA FRAGMENTATION%REACTOME DATABASE ID RELEASE 76%140342 Apoptosis induced DNA fragmentation H1-1 H1-0 H1-3 H1-2 H1-5 H1-4 KPNB1 DFFB DFFA HMGB1 HMGB2 CASP3 KPNA1 DEGRADATION OF BETA-CATENIN BY THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 76%195253 Degradation of beta-catenin by the destruction complex PPP2R1B PPP2R5E TCF7L2 TCF7L1 CTNNB1 CTBP2 PPP2R5B CTBP1 PPP2R5A PPP2R5D RBX1 PPP2R5C AMER1 FRAT1 FRAT2 TLE4 TLE3 TLE2 TLE1 TLE5 PPP2CA PPP2CB PPP2R1A BTRC CSNK1A1 SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 GSK3B PSME4 PSME1 PSME2 AXIN1 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 ZRANB1 PSMB2 UBB PSMB3 APC PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TCF7 LEF1 SEMA3A-PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION%REACTOME DATABASE ID RELEASE 76%399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion NRP1 PLXNA4 PLXNA3 FES FARP2 RND1 TLN1 RAC1 FYN RRAS SEMA3A PIP5K1C PLXNA2 PLXNA1 SIGNALING BY CTNNB1 PHOSPHO-SITE MUTANTS%REACTOME%R-HSA-4839743.2 Signaling by CTNNB1 phospho-site mutants PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 ERBB2 ACTIVATES PTK6 SIGNALING%REACTOME%R-HSA-8847993.1 ERBB2 Activates PTK6 Signaling PTK6 NRG1 NRG2 HBEGF NRG3 NRG4 ERBB2 EGFR EREG BTC EGF TICAM1-DEPENDENT ACTIVATION OF IRF3 IRF7%REACTOME DATABASE ID RELEASE 76%9013973 TICAM1-dependent activation of IRF3 IRF7 IKBKE UBB UBA52 UBC IRF3 TRAF3 TICAM1 RPS27A IRF7 TLR3 TBK1 TANK REGULATION OF COMPLEMENT CASCADE%REACTOME%R-HSA-977606.5 Regulation of Complement cascade V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 C3AR1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 C3 C5 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 CD81 IGHV4-39 C4BPA C4BPB C4A IGKV2-29 IGKV2-28 CPB2 IGLC3 CFH IGLC1 CFI IGLC2 C4B_2 V1-9 C2 V1-7 VTN V1-5 C6 V1-3 C7 C9 C8B IGKV3D-20 C8A C8G CR2 IGKV2-30 CR1 IGHV2-70 CD46 IGHV2-5 C1QB IGHV3-48 IGLV3-1 C1QA IGKV1-39 C1S IGKV1-33 C1R CPN2 CPN1 IGHV3-53 IGLC7 CFHR2 CFHR1 IGKV5-2 CFHR4 F2 IGLC6 CFHR3 CFHR5 C1QC ELANE PROS1 CD59 CD55 CLU SERPING1 IGHV3-23 IGLV2-8 IGKV1-16 C5AR2 IGKV1-17 C5AR1 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 CFB V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 CD19 HYPUSINYLATION%REACTOME%R-HSA-204626.1 Hypusinylation EIF5A2 DHPS DOHH EIF5A MTF1 ACTIVATES GENE EXPRESSION%REACTOME%R-HSA-5660489.1 MTF1 activates gene expression MTF1 CSRP1 SNCB VIRUS ASSEMBLY AND RELEASE%REACTOME%R-HSA-168268.3 Virus Assembly and Release PA PB2 NP NA NS HA M CALR PB1 CANX PLATELET AGGREGATION (PLUG FORMATION)%REACTOME DATABASE ID RELEASE 76%76009 Platelet Aggregation (Plug Formation) FN1 FGB F2 SHC1 FGA CRK VWF GP1BB SOS1 FGG GP1BA TLN1 ITGA2B PTPN1 GP5 SYK APBB1IP BCAR1 GP9 AKT1 PTK2 CSK MPL THPO PDPK1 RASGRP2 RASGRP1 ITGB3 RAP1B RAP1A ADRA2C ADRA2B RAPGEF3 RAPGEF4 ADRA2A SRC HYDROLYSIS OF LPC%REACTOME DATABASE ID RELEASE 76%1483115 Hydrolysis of LPC PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLBD1 PLA2G4A GPCPD1 FOXO-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-9614085.2 FOXO-mediated transcription FOXO3 CREBBP GADD45A BCL2L11 NR3C1 SIRT1 PCBP4 SMAD4 NFYA BBC3 SMAD3 NFYB NFYC GCK PPARGC1A YWHAQ SFN ABCA6 EP300 NPY BTG1 MSTN CITED2 IGFBP1 TRIM63 KAT2B SIRT3 DDIT3 CAT RETN PCK1 KLF4 YWHAG FBXO32 G6PC1 BCL6 PINK1 CCNG2 AGRP INS FOXO4 ATXN3 HDAC2 HDAC1 FASLG RBL2 CAV1 FOXO1 YWHAB STK11 POMC AKT2 AKT1 PLXNA4 YWHAZ SREBF1 FOXG1 SOD2 SIN3A FOXO6 TXNIP CDKN1A CDKN1B TXN SMAD2 AKT3 DEFECTIVE SLC22A5 CAUSES SYSTEMIC PRIMARY CARNITINE DEFICIENCY (CDSP)%REACTOME%R-HSA-5619053.1 Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP) SLC22A5 ACTIVATED NTRK2 SIGNALS THROUGH FRS2 AND FRS3%REACTOME DATABASE ID RELEASE 76%9028731 Activated NTRK2 signals through FRS2 and FRS3 NTF4 BDNF HRAS FRS2 SOS1 FRS3 NRAS PTPN11 NTRK2 THE ROLE OF GTSE1 IN G2 M PROGRESSION AFTER G2 CHECKPOINT%REACTOME%R-HSA-8852276.2 The role of GTSE1 in G2 M progression after G2 checkpoint TP53 HSP90AA1 HSP90AB1 PSMD8 PSMD9 GTSE1 PSMD6 FKBPL PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 MAPRE1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 CCNB2 PSMB4 CCNB1 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 CDK1 CDKN1A POST-TRANSLATIONAL PROTEIN PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 76%8957275 Post-translational protein phosphorylation FN1 APP PRKCSH GAS6 BPIFB2 APOB MGAT4A C3 MEN1 PENK IL6 CKAP4 C4A KTN1 ADAM10 SDC2 GPC3 TGOLN2 LAMC1 TF TIMP1 IGFBP3 MIA3 SERPINA1 PCSK9 IGFBP1 SERPINC1 CSF1 VCAN TNC APOA2 SPP1 DMP1 APOA1 LGALS1 CDH2 EVA1A APOA5 LAMB1 CCN1 CHGB IGFBP5 IGFBP4 FGA APLP2 SERPIND1 SHISA5 PDIA6 MXRA8 SPARCL1 SCG3 SCG2 FGG LTBP1 HSP90B1 STC2 IGFBP7 F5 AMELX WFS1 AMBN FUCA2 PROC APOE TMEM132A BMP4 HRC CALU MELTF FBN1 MBTPS1 SERPINA10 MSLN CHRDL1 PRSS23 CP BMP15 QSOX1 AHSG MEPE ALB DNAJC3 RCN1 P4HB VGF ENAM AMTN VWA1 KNG1 FAM20C FAM20A MFGE8 MATN3 ITIH2 AFP FGF23 FSTL1 ANO8 FSTL3 CST3 SPP2 APOL1 GOLM1 LAMB2 NUCB1 NOTUM PNPLA2 GAP JUNCTION TRAFFICKING AND REGULATION%REACTOME DATABASE ID RELEASE 76%157858 Gap junction trafficking and regulation GJA4 GJA9 GJD2 GJA8 GJD4 GJD3 TJP1 GJA10 GJC1 GJC2 MYO6 DAB2 DNM1 DNM2 GJB2 GJB1 GJB4 GJB3 GJB6 GJB5 GJB7 CLTA CLTC CLTB GJA1 CLTCL1 AP2M1 GJA3 GJA5 FORMATION OF RNA POL II ELONGATION COMPLEX%REACTOME%R-HSA-112382.2 Formation of RNA Pol II elongation complex CTDP1 RTF1 ELL MLLT3 CCNT1 SUPT6H SUPT4H1 IWS1 ELOA3DP LEO1 ELOA EAF1 NELFB EAF2 ELOB PAF1 ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 CCNK TCEA1 AFF4 CDC73 CTR9 WDR61 MLLT1 SYNTHESIS OF PYROPHOSPHATES IN THE CYTOSOL%REACTOME DATABASE ID RELEASE 76%1855167 Synthesis of pyrophosphates in the cytosol IP6K1 ITPK1 NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 NUDT3 IPPK NUDT4 BIOSYNTHESIS OF DPAN-3-DERIVED MARESINS%REACTOME%R-HSA-9026290.1 Biosynthesis of DPAn-3-derived maresins ALOX5 ALOX12 DEFECTIVE POMT2 CAUSES MDDGA2, MDDGB2 AND MDDGC2%REACTOME%R-HSA-5083629.1 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 POMT1 DAG1 POMT2 RNA POLYMERASE II TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%73857 RNA Polymerase II Transcription CREBBP CSF2 CBFB PRKCB RUNX1 IHH MAPK1 BGLAP MAPK3 MYL9 ITGA2B NCBP1 NCBP2 PLXNA4 ITGA5 MET CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 GRIN2B H2AX EHMT2 H2AB1 H2AC19 CHD4 CHD3 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 CHEK1 H2AJ KAT2A H2BC15 H2BC11 HDAC2 HDAC1 H3C15 RBBP4 H2BS1 RBBP7 MTA2 LDB1 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 DEK GATAD2B GATAD2A H2AC20 CASP10 HNF4G HDAC3 GCK CSNK2A1 CSNK2A2 CSNK2B NFKB1 MEN1 FKBP5 NOTCH2 NOTCH3 NOTCH4 TNFRSF10B TNFRSF10A YES1 TNFRSF10D VEGFA DAXX BLK ELF1 ELF2 PAX5 GPAM AGO3 AGO4 AGO1 AGO2 SKP2 FZR1 FASLG FAS SOCS3 PTPN1 PRKAA1 FOXO1 RPTOR STK11 AKT2 MLST8 SLC38A9 TSC2 TSC1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB OCLN RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 IRAK1 COL1A1 NOP2 HSPD1 PABPN1 CPSF4 TFAP2A TFAP2B TFAP2C CGB8 ATAD2 YY1 KIT MEF2C STAT1 LBR PPARD CEBPB SPI1 TAL1 DDIT3 KMT2A CDC25C HDAC6 TPX2 MYBL2 JAG1 CAV1 SNRPD3 SLBP PML CSTF3 CSTF1 SYMPK RB1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CCND1 CDK4 E2F1 PCF11 MAML2 MAML1 RBPJ WDR33 ITGAL MYC CCN2 TEAD1 TEAD2 TEAD3 TEAD4 BRD2 SRRT ITGA4 RUNX3 ATF2 MAML3 YAP1 NOTCH1 NUDT21 SRC TCF7 SERPINE1 LEF1 FOXO3 BCL2L11 HES1 SIRT1 WWTR1 TCF7L2 SMAD4 PAPOLA TCF7L1 ZFHX3 SMAD3 SMURF2 SNW1 CTNNB1 KRAS MAMLD1 GTF2A1 GTF2A2 GTF2B SNRPG PPARGC1A TAF9 TAF1L NR1D1 SNRPE GTF2E1 SNRPF GTF2E2 TAF7L TAF9B TAF15 TAF12 TAF13 SNRPB TAF10 TAF11 TAF7 TAF4B CPSF3 TAF6 CPSF2 TAF5 USP2 TAF4 TAF3 TAF2 TAF1 UBE2D3 PIN1 CSTF2T CASP2 FIP1L1 GP1BA MED1 SREBF1 SMARCD3 TBL1XR1 FOXO6 CARM1 NR4A1 TBL1X MRE11 TP53RK EHMT1 PRDM1 NOC2L KAT5 PIP4K2A PIP4K2B NBN KMT5A PIP4K2C TP63 HUS1 KAT6A MAPKAPK5 DNA2 RHNO1 L3MBTL1 BLM MEAF6 PPP2R1B MAPKAP1 BRIP1 NUAK1 SMYD2 TP53BP2 ATRIP BANP MAP2K6 TRPC3 BARD1 PLK3 BRPF1 BRPF3 JMY RAD17 PPP2R5C RAD9B TP73 ATR RAD9A PRR5 DYRK2 PPP1R13B SETD9 BRCA1 ING5 ING2 PIP4P1 EXO1 PPP1R13L PPP2CA TOPBP1 RFC5 PPP2CB PRMT5 RMI2 BRD1 RFC3 RFC4 RFC2 RMI1 PDPK1 TOP3A SGK1 RNF34 WRN PTPN11 TP53INP1 RBBP8 RICTOR RFFL BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 RAD50 TTC5 CALM1 RPA3 CCNG1 RAD1 CDK5R1 GLS GAMT EZH2 SIN3B EED SUZ12 JUN SOD2 PRDX2 PRDX1 RAD51D RAD51 MDC1 CCNK MT-CO1 TP53AIP1 COX7A2L SCO1 SCO2 DDIT4 MT-CO2 MT-CO3 TXN PRELID3A PRELID1 SURF1 CRADD GADD45A PLK2 CDK12 CDK13 GPI BTG2 COX7B COX7C BBC3 AIFM2 TNKS1BP1 COX8A CNOT6L PRMT1 FOS DDB2 PCNA COX5B COX5A PLAGL1 BDNF PERP PMS2 BID TIGAR NPM1 MLH1 COX6C LRPPRC STEAP3 CCNT2 TACO1 COX6A1 SESN3 SESN2 BNIP3L G6PD IGFBP3 COX6B1 MSH2 FANCD2 COX19 COX16 COX18 NDRG1 PMAIP1 COX11 COX14 BCL2L14 ZNF420 FANCI TNFRSF10C CNOT10 FANCC CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 CNOT2 CNOT3 CYCS CNOT8 CNOT9 COX20 COX4I1 PTEN TRIAP1 PIDD1 CASP6 CASP1 APAF1 RABGGTB RABGGTA RBL2 RBL1 RRM2B TMEM219 BIRC5 NLRC4 E2F4 E2F7 E2F8 NDUFA4 ARID3A BAX NPPA TBX5 NKX2-5 HDAC10 HDAC11 TXNIP CCNC GLS2 HEY1 HEY2 TXNRD1 ERBB2 MYB YWHAE ESR2 CDK8 PPP2R1A ZFPM1 PRKACA HDAC5 GATA4 GATA3 YWHAG HDAC8 HDAC9 GATA2 SKP1 DLL1 GATA1 HDAC7 ABL1 NFE2 CBX5 CDK5 UBA52 CUL1 AURKA IL6 CCNB1 UBB UBC RPS27A SIN3A CENPJ CRH CDK1 CR1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR4A2 NR5A1 AR RXRA SUMO1 RARA PPARG PGR PPARA CCNH RNMT POLR2A POLR2B POLR2C POLR2D GRIA2 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J GRIN2A POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 STUB1 ANAPC15 ANAPC16 BTG1 ANAPC7 MSTN UBE2C CITED2 UBE2E1 IGFBP1 UBE2D1 TRIM63 SIRT3 ANAPC10 CAT ANAPC11 CDC23 RETN PCK1 UBE2S CDC26 KLF4 FBXO32 CDC16 G6PC1 CDC27 ANAPC4 PINK1 ANAPC5 CCNG2 AGRP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 APOE PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 PSMC2 TCEA1 AFF4 CDC73 CTR9 SMAD2 CLP1 WDR61 TNFRSF18 MLLT1 RTF1 MLLT3 SUPT6H IWS1 LEO1 CSTF2 EAF1 EAF2 PAF1 CPSF1 GPX2 LSM10 LSM11 ZNF287 ZNF17 ZNF18 ZNF19 ZNF285 RBFOX1 ZNF282 NEDD4L ZNF10 ZNF12 ZNF14 CLDN5 ZNF28 ZNF274 ZNF273 ZNF20 ZNF23 ZNF25 ZNF26 ZNF268 ZNF267 ABCA6 PPARGC1B ZNF266 ZNF264 ZNF263 NR2F1 ZNF34 NR0B2 NR2F6 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 MED12 MED14 MED13 MED10 ZNF41 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ACTL6B RING1 WWP1 ZNF480 CGA MED27 MED26 MED23 MED25 MED24 MED20 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 SERPINB13 ZNF471 ZNF470 ZNF227 ZNF226 ZNF468 ZNF225 ZNF224 ZNF223 ZNF222 ZNF221 ZNF461 ZNF460 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF697 ZNF213 ZNF696 ZNF454 ZNF212 ZNF211 ZNF692 ZNF691 RORC RORB ZNF208 ZNF689 ZNF205 ZNF688 ZNF446 PITX2 AKT3 ZNF445 ZNF202 ZNF443 ZNF684 ZNF442 ZNF200 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ZFP69B FOXP3 MAF ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF675 ZNF433 PVALB ZNF432 ZNF431 KMT2E ZNF430 SFN ZNF671 KMT2D ZNF670 DLX5 DLX6 KMT2C KMT2B ZNF840P MED30 MOBP ZKSCAN7 ZNF429 MED31 ZKSCAN8 ZNF669 NPY ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 SOCS4 ZKSCAN1 CHM ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 SP7 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 HAND2 ZNF875 PPM1D ZNF627 PF4 ZNF626 ZNF625 ZNF624 ZNF621 E2F6 ZNF620 ZNF860 MGA ZNF619 IL2RA ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 PTPN4 ZNF610 EGFR TRIM33 SMARCB1 UXT ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 ZNF721 ZNF720 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B L3MBTL2 ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 ZNF700 HIVEP3 INTS1 INTS3 INTS2 SMARCA2 SMARCA4 INTS5 ITGBL1 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 BMI1 HNF4A PBRM1 SATB2 RXRB ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 ZFP28 PRDM7 ICE1 ICE2 ARID2 MSX2 SSU72 ZNF99 GPRIN1 TFAP2D TFAP2E AUTS2 IL2 IL3 BMP2 NABP2 NABP1 TCF3 DPY30 TGIF1 RBM14 ZNF75CP TGIF2 RNF2 OPRM1 RRM2 ZNF804B TAF8 ZNF175 PHAX ZSCAN32 ZNF169 JUNB SLC2A3 ZNF705F ZNF705G ZNF705D ZNF705E ZNF160 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NR2C2AP ZNF143 PHC2 PHC1 ZNF383 ZNF141 ZNF382 ZNF140 SETD1B SETD1A OPRK1 NFATC2 NR1D2 CDC7 ELL2 PHC3 ELL3 ZNF37A ZNF702P POMC ZNF138 SST ZNF136 ZNF135 ZNF133 RARG ASH2L RSPO3 ZNF124 ZIK1 TCF12 RARB ZNF599 ZNF114 ZNF597 ZNF112 ZNF596 ZNF595 RNF111 ZNF350 ZNF347 ZNF589 PARP1 ZNF587 ZNF586 ZIM2 ZNF343 ACTL6A ZIM3 ZNF101 ZNF100 ZNF584 WWOX ZNF583 PCGF6 CDKN2B ZNF582 PCGF5 PCGF2 ZNF33B ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 YEATS4 ZFP30 TGFA ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZFP37 ZNF565 ZNF564 EIF4A3 ZNF563 CASC3 ZNF562 ZNF320 ZNF561 MAGOH ZNF560 THOC1 THOC3 NRBP1 THOC2 ZNF559 THOC5 ZNF317 CDC40 ZNF558 CTSL THOC7 ZNF557 THOC6 ZNF799 DDX39A CTSK ZNF556 DDX39B ZNF555 ZC3H11A ZNF554 SARNP ZNF311 SRSF2 ZNF552 SRSF3 ZNF551 SRSF4 ZNF793 SRSF5 ZNF550 SRSF6 CSF1R SRSF7 ZNF792 SLU7 ZNF791 SRSF9 ZNF790 KRBA1 FYTTD1 KRBOX4 LUZP4 RBM8A ZNF767P ZNF549 POLDIP3 SRSF1 ZNF548 U2AF1 ZNF547 ZNF546 U2AF1L4 ZNF304 U2AF2 ZNF544 MMP13 DHX38 ZNF302 SRSF11 ZNF786 ZNF543 CHTOP ZNF785 ALYREF UPF3B SKIL MAGOHB ZNF300 ZNF782 ESRRA RNPS1 ZNF540 ZNF658B IFNG ESRRB ESRRG ZFP69 ZNF778 ZNF777 SPP1 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 ZC3H8 ZNF529 ZNF528 WDR5 ZNF764 TJP1 ZNF521 ZNF761 ZNF75D ZNF75A ZFP90 ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 SMARCD1 SMARCD2 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 ZNF500 ZNF740 SMARCE1 RPRD2 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 SOX2 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 TWIST2 TWIST1 RPAP2 ZNF726P1 CITED1 CITED4 VENTX PRMT6 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B LMO1 LMO2 KCTD1 ATP1B4 LIFR KCTD6 RPRD1B RPRD1A CBX8 CBX6 POU2F1 CBX4 CBX2 SMAD6 POU2F2 NR4A3 KDM5B THRA NR2E1 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ARID1A ARID1B ZNF197 ZNF195 NR2C2 THBS1 YWHAQ ZNF286A ZNF189 ZNF184 YWHAH ZNF180 PRKAB2 PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 INS FOXO4 ATXN3 USP9X SMAD1 SMAD7 GSK3B AXIN1 YWHAB AKT1 YWHAZ CAMK2B CAMK2D FOXG1 CAMK2A GPS2 HTT AURKB CAMK2G HIPK2 NCOR2 TNRC6C MOV10 CREB1 NCOR1 CAMK4 TNRC6A TNRC6B MAPK14 MAPK11 PRKCQ CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 CCNA1 CCNE2 CCNE1 TP53 PCBP4 NFYA CDKN2A CDK2 MDM2 NFYB ATM NFYC MDM4 RBX1 SP1 MAX E2F5 GLI3 GLI2 ITCH CPSF7 SRRM1 RELA TGFB1 SMURF1 LGALS3 ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON%REACTOME DATABASE ID RELEASE 76%936964 Activation of IRF3 IRF7 mediated by TBK1 IKK epsilon UBB TICAM2 UBC LY96 TICAM1 RPS27A CD14 TLR4 IRF7 PTPN11 TBK1 IKBKE UBA52 IRF3 TRAF3 TANK TRNA-DERIVED SMALL RNA (TSRNA OR TRNA-RELATED FRAGMENT, TRF) BIOGENESIS%REACTOME%R-HSA-9708296.1 tRNA-derived small RNA (tsRNA or tRNA-related fragment, tRF) biogenesis DICER1 ELAC2 ANG CELLULAR RESPONSE TO CHEMICAL STRESS%REACTOME%R-HSA-9711123.1 Cellular response to chemical stress CREBBP HDAC3 KEAP1 NOX4 TXNRD1 GPX2 CSNK2A1 GPX1 NCF1 CSNK2A2 NCF2 NCF4 CSNK2B ERO1A ATOX1 NUDT2 PRDX3 PRDX6 NOX5 HMOX2 NFE2L2 GPX3 GPX6 GPX5 GPX8 GPX7 BLVRB BLVRA HM13 GSTP1 TXNRD2 CYBB SOD3 CYBA SOD1 CCS SKP1 ABCC1 UBA52 MAFK NLRP3 STAT3 CUL1 PRKCD UBB HBB UBC SOD2 PRDX2 RPS27A PRDX1 SIN3A NCOR2 NCOR1 MT-CO1 FABP1 COX7A2L AQP8 SCO1 SCO2 MT-CO2 MT-CO3 TXN SURF1 COX7B COX7C COX8A RXRA RBX1 COX5B PPARA COX5A COX6C LRPPRC SKP2 TACO1 COX6A1 COX6B1 COX19 COX16 COX18 FBXL17 BACH1 COX11 COX14 TXN2 CAT PSMD8 PSMD9 CYCS PSMD6 PSMD7 PSMD4 COX20 COX4I1 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 STAP2 PSME1 PSME2 PSMD10 PSMB11 PSMD12 NDUFA4 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 ATP7A PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 NCOA1 PSMB3 MED1 PSMB1 PSMF1 ALB NCOA2 PSMB8 P4HB SMARCD3 PSMB9 SEM1 CHD9 NCOA6 PSMC5 HELZ2 PSMC6 TBL1XR1 PSMC3 TGS1 PSMC4 CARM1 PSMC1 TBL1X PSMC2 PTK6 TXNIP HBA2 HMOX1 AMYLOID FIBER FORMATION%REACTOME DATABASE ID RELEASE 76%977225 Amyloid fiber formation NCSTN B2M SIAH2 APP SIAH1 LYZ H2AX H2AB1 H2AC19 PRKN TTR SEMG1 H2AC14 H2BC21 H2BU1 H3-3B H3C8 GSN UBE2L6 H2AC8 H2AC6 APH1A H2AC7 APH1B CALB1 H2BC17 NAT8B H2BC12 BACE1 H2BC13 APCS H2BC14 TSPAN33 TSPAN5 SNCA H2BC15 ODAM SNCAIP SORL1 FURIN TSPAN15 H2BC11 TSPAN14 NAT8 TGFBI INS ITM2B APOA1 APOA4 SAA1 PSENEN IAPP USP9X CALCA H3C15 FGA H2BS1 H2AZ1 H2BC9 UBA52 H4C9 H2BC8 H2BC5 APOE H2BC3 GGA2 GGA1 H2BC1 GGA3 H2AC20 UBB PRL UBC RPS27A NPPA MFGE8 CST3 ADAM10 HSPG2 LTF TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR%REACTOME%R-HSA-1679131.1 Trafficking and processing of endosomal TLR CNPY3 HSP90B1 LGMN CTSS CTSB UNC93B1 CTSL TLR9 CTSK TLR7 TLR3 TLR8 SUMOYLATION%REACTOME%R-HSA-2990846.4 SUMOylation CREBBP BLM CBX8 CBX4 NUP42 CBX2 NUP43 RAE1 SENP1 RANBP2 MRTFA BMI1 CDCA8 SATB2 TFAP2B NUP35 TFAP2C NUP37 TRIM27 BRCA1 ING2 INCENP CETN2 TDG RNF2 WRN RPA1 HDAC7 SMC5 PARK7 SMC6 SMC3 DDX5 VHL HERC2 DDX17 NSMCE3 PHC2 CBX5 NSMCE2 PHC1 NSMCE1 MITF RING1 HIC1 EID3 RAD21 DNMT1 ZBED1 TP53BP1 XRCC4 STAG1 STAG2 PHC3 SP3 ZNF131 SENP5 FOXL2 DNMT3B SMC1A SENP2 SAFB RNF168 NSMCE4A RANGAP1 SP100 AURKA PML UHRF2 NUP214 CASP8AP2 NOP58 MBD1 RAD52 SUZ12 HNRNPK ZNF350 AURKB DAXX PARP1 HIPK2 SIN3A NCOR2 RWDD3 UBA2 SAE1 MDC1 PCGF2 PIAS4 XPC HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 TP53 NR2C1 ESR1 NR3C2 CDKN2A PIAS1 NR4A2 MDM2 NR5A1 AR RXRA SUMO1 CTBP1 SUMO3 SUMO2 RARA NRIP1 PPARG PCNA PGR PPARGC1A PPARA TOP2A NPM1 CHD3 EP300 SEC13 IKBKE NUP107 NUP188 HDAC2 HDAC1 NUP210 MTA1 NUP93 POM121 NUP205 BIRC5 AAAS H4C9 NUP160 POM121C NUP85 TPR NUP88 TRIM28 NUP155 HNRNPC NUP153 NCOA1 NCOA2 NFKBIA RELA TOPORS NFKB2 IKBKG TOP2B L3MBTL2 NUP62 TOP1 SATB1 NDC1 NUP133 NUP50 NUP54 CELLULAR RESPONSES TO EXTERNAL STIMULI%REACTOME%R-HSA-8953897.4 Cellular responses to external stimuli CREBBP NOX4 TXNRD1 ATP6V1H MAPK1 IL1A MAPK3 HSP90AA1 YWHAE ACTR1A RPL4 RPL5 RPL30 RPL3 SKP1 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 DYNLL1 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 AJUBA MAFK RPS11 RPL39 NLRP3 RPS10 RPS13 DYNC1I2 RPS12 DCTN2 RPS9 DCTN3 RPS7 CUL1 RPL21 IL6 RPS8 RPS5 UBB RPL23 RPL22 HBB RPS6 RPL13A UBC RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 CAPZB SIN3A RPL26 RPL29 DYNC1H1 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RORA RPL39L RPL41 NR3C1 RPL35A RPL23A RPL3L NR3C2 ELOB RPS26 ELOC RPS25 RPS28 AR RPS27 RPS29 RXRA RPL27A RPL22L1 IFNB1 RPS20 FAU RPS21 PGR RPL26L1 PPARA RPS24 RPS23 CAPZA1 CAPZA2 H2AX EHMT2 H2AB1 H2AC19 CSRP1 SNCB H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 FBXL17 H2AC8 BACH1 H2AC6 ANAPC15 H2AC7 ANAPC16 ANAPC7 H2BC17 CITED2 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 ANAPC10 H2BC14 ANAPC11 H2AJ CAT CDC23 UBE2S H2BC15 CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 APOA1 PSMD7 PSMD4 PSMD5 PSMD2 H3C15 PSMD3 NUP210 PSMD1 PSMA5 RBBP4 NUP93 PSMA6 PSMA3 H2BS1 VCP POM121 PSMA4 RBBP7 NUP205 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 IGFBP7 H2AZ2 PSMD10 AAAS H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 POM121C PSMD14 NUP85 H2BC3 PSMD13 TPR NUP88 PSMA7 H2BC1 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 H2AC20 PSMB4 NUP153 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 ALB PSMB8 P4HB PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NUP62 NDC1 NUP133 NUP50 NUP54 HDAC3 NUP42 NUP43 RAE1 RANBP2 NUP35 GPX2 CSNK2A1 GPX1 NUP37 CSNK2A2 CSNK2B HMOX2 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP NFKB1 HSP90AB1 STIP1 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 DNAJA4 DNAJA2 FKBP4 HSPA1B FKBP5 RING1 STAT3 VEGFA FABP1 TCIRG1 DYNC1LI1 DYNC1LI2 AGO3 AGO4 AGO1 SKP2 FZR1 SLC46A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 FLCN SESN1 C12orf66 SZT2 MIOS ITFG2 ATP6V0D1 KPTN ATP6V0D2 DEPDC5 SEH1L LY96 NPRL2 NPRL3 WDR24 SH3BP4 FNIP1 EPAS1 TLR4 FNIP2 HIF1A WDR59 CASTOR1 CASTOR2 STAP2 BMT2 ATP6V1C1 ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR H1-1 H1-0 RRAGA H1-3 H1-2 RRAGC H1-5 RHEB H1-4 RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 ATP6V0B LAMTOR5 HBA2 ATP6V0C ATP6V1G3 ATP6V0E2 BMI1 CXCL8 NCF1 NCF2 MEF2C NCF4 RPS6KA3 RPS6KA2 RPS6KA1 ATP6V1A ATP6V1D ATP6V1F CYBB RNF2 PPP1R15A CYBA CEBPB EIF2AK1 CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 GRB10 TRIB3 CHAC1 ATF5 ATF3 ATF4 ABCC1 HSBP1 HSF1 HDAC6 ATP6V1B2 ATP6V1B1 PHC2 PHC1 PHC3 RB1 TFDP1 CDK6 TFDP2 CDK4 E2F1 E2F2 E2F3 CDKN2B ATF2 CRTC2 CRTC3 CRTC1 SIRT1 CLOCK NPAS2 ARNTL RAI1 NRIP1 MEF2D PPARGC1A NR1D1 UBE2D2 UBE2D3 BAG4 SEC13 DYNC1I1 CAPZA3 ACTR10 ATP7A MAP2K3 MAP2K4 NCOA1 MED1 MAPKAPK3 MAP2K7 NCOA2 SMARCD3 CHD9 NCOA6 MAPK9 HELZ2 TBL1XR1 MAPK10 TGS1 CARM1 TBL1X MRE11 EEF1A1 EHMT1 VENTX KAT5 NBN MAPKAPK5 KEAP1 CBX8 CBX6 CBX4 CBX2 MAP2K6 ATR ERO1A ATOX1 NUDT2 PRDX3 PRDX6 NOX5 NFE2L2 GPX3 GPX6 GPX5 HSPA8 GPX8 APOB GPX7 BLVRB BLVRA HM13 GSTP1 TXNRD2 SOD3 SOD1 CCS RPA1 RPA2 DCTN6 DCTN5 RAD50 DCTN1 RPA3 DCTN4 MAPK8 DYNLL2 HIF3A LIMD1 CUL2 VHL EGLN1 EGLN3 EGLN2 WTIP GSK3B EZH2 EED XPO1 NUP214 PRKCD MAPK7 ASF1A SUZ12 CAMK2B HSPA4L CAMK2D HSPH1 JUN MAPKAPK2 ST13 CAMK2A SOD2 EIF2AK4 LMNB1 PRDX2 CRYAB PRDX1 HSPA14 HSPA13 CAMK2G UBN1 NCOR2 CDKN2D CDKN2C TNRC6C MOV10 EPO HIKESHI CREB1 NCOR1 MAP3K5 ERF TNIK TNRC6A MT-CO1 BAG5 TNRC6B BAG2 BAG3 COX7A2L MAPK14 SCO1 BAG1 ARNT AQP8 MAPK11 SCO2 HIF1AN CLEC1B MT-CO2 HSPA1A DNAJC2 MT-CO3 CDKN1A IMPACT CDKN1B DNAJC7 TXN DNAJB6 MT1M MT1X SURF1 CCAR2 CCNA2 MT2A CCNA1 MT1A CCNE2 MT1F CCNE1 MT1G TP53 MT1H MT1B CDKN2A MT1E COX7B CDK2 HSPA12A COX7C MDM2 HSPA12B ID1 ATM MDM4 MINK1 COX8A HIRA MAP4K4 ETS1 FOS ETS2 RPS19BP1 RBX1 SP1 HIGD1A MTF1 COX5B EP400 COX5A GCN1 HSPA9 HSPA5 HSPA4 PSPHP1 HSPA7 HSPA6 HMGA1 COX6C HMGA2 LRPPRC MT4 MT3 HSPB8 TACO1 CABIN1 COX6A1 CA9 KDM6B SESN2 COX6B1 COX19 COX16 COX18 COX11 COX14 TXN2 CYCS COX20 COX4I1 ASNS CUL3 NDUFA4 RELA PTK6 TXNIP HMOX1 TOLL LIKE RECEPTOR 2 (TLR2) CASCADE%REACTOME%R-HSA-181438.1 Toll Like Receptor 2 (TLR2) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN RPS27A CREB1 MAPK14 MAPK11 ATF2 FOS S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 PELI1 SOCS1 IRAK4 SAA1 MYD88 LY96 FGB FGA CD14 TLR4 FGG ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 PI-3K CASCADE:FGFR2%REACTOME%R-HSA-5654695.2 PI-3K cascade:FGFR2 GAB1 FGF1 FGF2 PIK3CA FGF3 FGF4 FGF6 PTPN11 FGF7 FGF9 FGF20 FGF23 PIK3R1 FGF22 FRS2 FGF16 FGF18 FGF10 DEFECTIVE SFTPA2 CAUSES IPF%REACTOME DATABASE ID RELEASE 76%5687868 Defective SFTPA2 causes IPF SFTPA2 RECRUITMENT AND ATM-MEDIATED PHOSPHORYLATION OF REPAIR AND SIGNALING PROTEINS AT DNA DOUBLE STRAND BREAKS%REACTOME DATABASE ID RELEASE 76%5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks TP53 ATM SUMO1 BRCC3 BARD1 BAP1 BABAM1 BABAM2 BRCA1 UIMC1 H2AX RNF8 NSD2 APBB1 KDM4A H2BC21 KDM4B EYA1 H2BU1 EYA2 EYA3 EYA4 PPP5C BAZ1B H2BC17 H2BC12 H2BC13 H3-4 H2BC14 H2BC15 RAD50 H2BC11 MAPK8 ABL1 HERC2 H2BS1 UBXN1 TP53BP1 H2BC9 UBA52 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 RNF168 ABRAXAS1 UBB UBC RPS27A MRE11 MDC1 KAT5 UBE2V2 NBN PIAS4 CHEK2 UBE2N UBE2I POSTMITOTIC NUCLEAR PORE COMPLEX (NPC) REFORMATION%REACTOME%R-HSA-9615933.1 Postmitotic nuclear pore complex (NPC) reformation NUP43 NUP93 KPNB1 POM121 SUMO1 RCC1 RAN NUP205 SEC13 NUP35 NUP62 NUP37 NDC1 NUP133 NUP160 AHCTF1 NUP85 NUP107 NUP188 NUP155 RANGAP1 NUP54 UBE2I TNPO1 INTERCONVERSION OF 2-OXOGLUTARATE AND 2-HYDROXYGLUTARATE%REACTOME%R-HSA-880009.1 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate ADHFE1 D2HGDH L2HGDH CREB1 PHOSPHORYLATION THROUGH NMDA RECEPTOR-MEDIATED ACTIVATION OF RAS SIGNALING%REACTOME DATABASE ID RELEASE 76%442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling ACTN2 RASGRF2 RASGRF1 GRIN2B RPS6KA6 MAPK1 GRIN1 RPS6KA3 GRIN2D DLG1 RPS6KA2 DLG2 RPS6KA1 DLG3 MAPK3 LRRC7 DLG4 NEFL CAMK2B CAMK2D HRAS CAMK2A PDPK1 CAMK2G NRAS CREB1 CALM1 MYOGENESIS%REACTOME%R-HSA-525793.2 Myogenesis CDH2 ABL1 CTNNA1 MAP2K6 CTNNB1 MEF2D MEF2A MEF2C MAPK12 TCF12 TCF3 NTN3 CDH4 BNIP2 NEO1 CTNNA2 CDON SPAG9 MAPK14 CDC42 MYOG MAPK11 MEF2B MYOD1 MYF6 TCF4 CDH15 MYF5 CYCLIN A:CDK2-ASSOCIATED EVENTS AT S PHASE ENTRY%REACTOME%R-HSA-69656.3 Cyclin A:Cdk2-associated events at S phase entry CCNA1 CCNE2 CCNE1 CDK2 CABLES1 WEE1 CCNH MAX E2F5 SKP2 FZR1 CDK7 MNAT1 CDC25A SKP1 CKS1B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 CDC25B PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 LIN54 RBL2 PSMA4 PSMA1 PSMA2 LIN52 PSME3 PSME1 PSME2 E2F4 UBA52 PSMD10 LIN37 PSMD12 LIN9 PSMD11 PSMD14 PSMD13 AKT2 PSMA7 PSMB10 CUL1 AKT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB RB1 PSMB3 PSMB1 TFDP1 PSMF1 UBC PSMB8 TFDP2 PSMB9 CCND1 RPS27A SEM1 PSMC5 CDK4 E2F1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 MYC CDKN1A CDKN1B AKT3 CCNA2 MITOTIC G1 PHASE AND G1 S TRANSITION%REACTOME%R-HSA-453279.4 Mitotic G1 phase and G1 S transition PPP2R1B PPP2CA PPP2CB RRM2 PPP2R1A RPA1 RPA2 RPA3 SKP1 PPP2R2A ABL1 LIN54 MYBL2 LIN52 CDC7 UBA52 LIN37 LIN9 PPP2R3B CUL1 AKT1 LYN CCNB1 UBB CDKN1C RB1 CCND3 TFDP1 UBC CDK6 CCND2 TFDP2 CCND1 POLE RPS27A CDK4 E2F1 E2F2 E2F3 CDKN2D CDKN2C MYC JAK2 CDKN2B CDK1 CDKN1A CDKN1B AKT3 CCNA2 CCNA1 CCNE2 CCNE1 POLE4 CDKN2A CDK2 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 CABLES1 PCNA WEE1 CCNH TOP2A MAX E2F5 MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDK7 CDC6 MNAT1 CDC25A CKS1B GMNN PSMD8 PSMD9 FBXO5 PSMD6 DYRK1A PSMD7 MCM10 PSMD4 TK1 HDAC1 DBF4 PSMD5 TYMS PSMD2 RPA4 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 E2F6 RBL2 PSMA4 RBL1 PSMA1 PSMA2 PSME3 CDC45 PSME1 PSME2 E2F4 PSMD10 PSMD12 PSMD11 DHFR PSMD14 PSMD13 AKT2 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 INTERFERON SIGNALING%REACTOME%R-HSA-913531.2 Interferon Signaling OAS1 IRF4 OAS2 OAS3 IRF8 KPNA7 IRF5 KPNA4 IRF6 KPNA5 USP41 KPNA2 EIF4E2 KPNA3 IRF9 SAMHD1 EIF2AK2 TRIM46 TRIM48 GBP2 FCGR1B GBP1 GBP4 GBP3 TRIM45 MX2 MX1 TRIM35 TRIM38 ABCE1 TRIM31 TRIM34 MAPK3 KPNA1 STAT1 KPNB1 IFNA13 IFNA14 IFNA16 IFNA17 IFNA10 IFNA21 UBA52 IFNA5 IFNA4 HLA-H IFNA7 HLA-B PML HLA-C IFNA6 HLA-F HLA-G HLA-E UBB IFNA2 UBC IFNA8 RPS27A JAK2 FCGR1A IRF1 IRF2 PIAS1 B2M SUMO1 HLA-A IFNB1 EIF4A3 UBA7 NS UBE2L6 NEDD4 HERC5 SEC13 UBE2E1 ISG15 CD44 IRF3 SOCS1 NUP107 PIN1 IFNG IFNGR1 NUP188 IFNGR2 JAK1 NUP210 NUP93 TRIM21 POM121 IRF7 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NCAM1 NUP153 PSMB8 DDX58 TRIM25 ADAR NUP62 NDC1 NUP133 NUP50 NUP54 IP6K2 NUP42 NUP43 RAE1 RANBP2 NUP35 NUP37 FLNA PTPN11 PTPN6 TYK2 SP100 NUP214 PRKCD USP18 CAMK2B CAMK2D CAMK2A CAMK2G EIF4G1 MT2A PLCG1 PTAFR IFNAR1 STAT2 EIF4A2 IFITM3 EIF4A1 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 IFI30 SOCS3 IFIT3 ICAM1 IFIT2 PTPN1 TRIM29 TRIM26 TRIM22 GBP6 GBP5 RSAD2 IFI27 TRIM17 PDE12 TRIM14 TRIM10 HLA-DQA2 EIF4E HLA-DQA1 EGR1 HLA-DRB5 HLA-DRB4 BST2 HLA-DRB3 HLA-DRB1 TRIM8 TRIM6 TRIM5 TRIM2 TRIM3 ARIH1 HLA-DPA1 HLA-DQB2 HLA-DQB1 RNASEL IFI6 gag FLNB HLA-DPB1 MID1 VCAM1 ISG20 HLA-DRA XAF1 EIF4G3 EIF4G2 CIITA EIF4E3 OASL UBE2N TRIM68 TRIM62 PPM1B PROTON OLIGOPEPTIDE COTRANSPORTERS%REACTOME%R-HSA-427975.2 Proton oligopeptide cotransporters SLC15A3 SLC15A4 SLC15A1 SLC15A2 TRAF6-MEDIATED INDUCTION OF TAK1 COMPLEX WITHIN TLR4 COMPLEX%REACTOME%R-HSA-937072.2 TRAF6-mediated induction of TAK1 complex within TLR4 complex TAB1 UBB TICAM2 UBC LY96 TICAM1 RPS27A CD14 TLR4 UBA52 IRAK2 TRAF6 TAB3 TAB2 MAP3K7 NEUTROPHIL DEGRANULATION%REACTOME%R-HSA-6798695.2 Neutrophil degranulation ATG7 GSDMD RHOF DIAPH1 SDCBP MAPK1 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 ARMC8 SCAMP1 RNASE2 UNC13D HSP90AA1 FLG2 PADI2 A1BG CFP PLAC8 CRACR2A KPNB1 PRDX4 GSN S100A11 RAB7A FUCA1 PA2G4 AZU1 HRNR TCN1 TOLLIP SERPINA3 PYGB PIGR SIGLEC9 LPCAT1 PYCARD PYGL CEP290 OLR1 SERPINB3 SERPINB1 NFAM1 PGAM1 TMC6 SERPINB6 PLEKHO2 SERPINB10 SERPINB12 TUBB GRN ASAH1 METTL7A AGA AGL ERP44 LRG1 YPEL5 DYNLL1 SIGLEC5 GPR84 GHDC TMEM179B RAB3D HP EPX RAB44 MLEC LAMP1 CLEC5A LAMP2 TOM1 KCMF1 IST1 OLFM4 ILF2 ACLY CLEC4C CLEC4D RAB37 HLA-H DSC1 HLA-B ARL8A HLA-C BRI3 UBR4 RAB4B PTPRB FCN1 NIT2 HBB PTPRC SNAP25 ITGAM ITGB2 FCAR ALAD FCGR3B GM2A ITGAX ACP3 PGM1 RNASET2 DYNC1H1 NDUFC2 PKM ITGAV DNAJC5 RAC1 TMBIM1 TUBB4B CANT1 FGL2 RAB24 CPPED1 PFKL CHIT1 CR1 VAPA MGAM MNDA FOLR3 VPS35L CALML5 ANPEP CPNE1 CPNE3 GOLGA7 ARSA NFASC C6orf120 KRT1 MIF SLPI DOCK2 CRISPLD2 FCGR2A TMEM63A MMTAG2 SYNGR1 COMMD9 ARSB B2M VAT1 HLA-A PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 BST1 CYSTM1 ORM1 PTPRJ ORM2 GLIPR1 ACTR1B CTSH CD33 LRRC7 CD53 MANBA FCER1G MME ALOX5 GAA NME2 COMMD3 CAP1 CEACAM3 TTR RAP2C CEACAM1 RAP2B CEACAM6 ALDOC CEACAM8 CD47 ALDOA DNASE1L1 CSTB FRK CD63 LILRA3 PGRMC1 CREG1 ORMDL3 CD58 AP2A2 LAIR1 GCA TYROBP CAT PTGES2 RETN APEH HUWE1 LILRB2 DERA LILRB3 SVIP QPCT PGM2 CD68 SRP14 PLAU COTL1 PSMD6 SIRPA PSMD7 ENPP4 OSTF1 CHRNB4 CD93 PSMD2 CD300A PSMD3 HVCN1 IRAG2 PSMD1 NPC2 ATAD3B PSMA5 OSCAR DOK3 PPIA VCP ADGRG3 CNN2 DPP7 PSMA2 ALDH3B1 GGH ADA2 DNAJC13 SELL TARM1 MAN2B1 PSMD12 DEGS1 FUCA2 PSMD11 MS4A3 PSMD14 DDX3X PSMD13 TNFAIP6 CRISP3 SIRPB1 HEBP2 HK3 ADGRE5 PSMB7 NAPRT ADGRE3 HGSNAT DYNLT1 QSOX1 ATP6AP2 AHSG PSMB1 PLAUR CHI3L1 DNAJC3 PDXK CLEC12A MVP AGPAT2 TMEM30A CMTM6 PSMC3 PDAP1 GALNS PTX3 PSMC2 RAP1B PPIE S100P RAP1A GLA CST3 TNFRSF1B JUP ARHGAP9 CSNK2B RHOG MAGT1 PLD1 IQGAP2 C3AR1 HMOX2 DDOST NFKB1 FPR1 HSP90AB1 FPR2 C3 STK10 HSPA1B SLCO4C1 ATP8A1 CCT8 PPBP DSP ATP11B CKAP4 ATP11A DSG1 DGAT1 SLC15A4 DSN1 B4GALT1 HEXB FAF2 FABP5 ATP8B4 TCIRG1 DYNC1LI1 GNS ARHGAP45 PTAFR CXCR1 CXCR2 NEU1 SERPINA1 CTSA VNN1 MOSPD2 GLB1 VAMP8 TICAM2 TRPM2 CD14 PAFAH1B2 CAB39 ATP6V0A1 AMPD3 APRT PNP GYG1 C5AR1 RAB3A SLC44A2 LAMTOR2 LAMTOR1 DBNL LAMTOR3 RAB31 PKP1 PSAP ANO6 FTL RAB5B RAB5C S100A12 ATP6V0C RAB6A AP1M1 TXNDC5 MPO ANXA2 TRAPPC1 CYFIP1 VCL ARPC5 SNAP23 CXCL1 STBD1 ATP6V1D SNAP29 CYBB ACTR2 CYBA SLC2A3 NCKAP1L RAB10 CAND1 STOM RAB14 RAB18 FTH1 TBC1D10C CAPN1 PRSS2 ITGAL ADAM10 ADAM8 PSEN1 NCSTN ELANE SURF4 CTSS RAB27A MMP25 SLC2A5 TIMP2 CTSG CTSZ CTSD GDI2 CTSB MMP8 MMP9 CTSC CD44 PRCP CD59 CD177 CD55 XRCC6 XRCC5 ACTR10 GUSB STING1 RAB9B PGLYRP1 HPSE PRSS3 CAMP SLC11A1 RNASE3 BPI PRTN3 EEF1A1 S100A9 S100A8 EEF2 TLR2 COPB1 LTF S100A7 MGST1 CYB5R3 DEFA1B IGF2R DEFA4 FGR PECAM1 LYZ PRDX6 LCN2 HSPA8 GSTP1 IQGAP1 AOC1 P2RX1 PTPN6 TSPAN14 SPTAN1 LTA4H PRKCD MAPK14 HSPA1A IDH1 CDK13 GPI ARG1 HMGB1 HSPA6 CD36 ACAA1 KCNAB2 SLC27A2 IMPDH1 IMPDH2 APAF1 CCT2 ROCK1 BST2 NRAS CFD RHOA BIN2 LGALS3 ALKBH3 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME%R-HSA-112126.1 ALKBH3 mediated reversal of alkylation damage ALKBH3 ASCC1 ASCC2 ASCC3 ESTABLISHMENT OF SISTER CHROMATID COHESION%REACTOME%R-HSA-2468052.1 Establishment of Sister Chromatid Cohesion STAG1 STAG2 ESCO1 CDCA5 SMC3 PDS5B ESCO2 PDS5A SMC1A WAPL RAD21 CGMP EFFECTS%REACTOME DATABASE ID RELEASE 76%418457 cGMP effects PDE11A KCNMB1 KCNMB2 KCNMB3 PRKG2 KCNMB4 PDE2A IRAG1 KCNMA1 PDE10A PDE9A PDE1B PDE5A PDE1A ITPR1 DEFECTIVE SLC2A10 CAUSES ARTERIAL TORTUOSITY SYNDROME (ATS)%REACTOME DATABASE ID RELEASE 76%5619068 Defective SLC2A10 causes arterial tortuosity syndrome (ATS) SLC2A10 DEFECTIVE ABCC8 CAN CAUSE HYPO- AND HYPER-GLYCEMIAS%REACTOME DATABASE ID RELEASE 76%5683177 Defective ABCC8 can cause hypo- and hyper-glycemias ABCC8 KCNJ11 RUNX2 REGULATES GENES INVOLVED IN CELL MIGRATION%REACTOME DATABASE ID RELEASE 76%8941332 RUNX2 regulates genes involved in cell migration MMP13 ITGBL1 CBFB ITGA5 AKT2 AKT1 AKT3 EXPRESSION AND PROCESSING OF NEUROTROPHINS%REACTOME DATABASE ID RELEASE 76%9036866 Expression and Processing of Neurotrophins NGF PCSK6 PCSK5 FURIN CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM%REACTOME DATABASE ID RELEASE 76%1793185 Chondroitin sulfate dermatan sulfate metabolism GPC5 GPC4 CHST14 GPC6 B3GAT3 B3GALT6 ARSB SDC1 AGRN B4GALT7 DCN CSGALNACT1 CHST7 CHPF CHPF2 NCAN CSGALNACT2 BGN VCAN CHSY1 CHST11 CHST12 CHST15 CSPG5 CSPG4 CHSY3 CHST13 CHST3 XYLT2 XYLT1 IDS IDUA B3GAT2 B3GAT1 HSPG2 BCAN SDC4 SDC2 HEXB SDC3 HEXA HYAL1 DSE HYAL3 GPC1 DSEL GPC3 UST GPC2 RUNX1 REGULATES GENES INVOLVED IN MEGAKARYOCYTE DIFFERENTIATION AND PLATELET FUNCTION%REACTOME DATABASE ID RELEASE 76%8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function CBFB RUNX1 NR4A3 PRMT1 AGO3 AGO4 AGO1 KMT2E THBS1 KMT2D H2AX H2AB1 KMT2C H2AC19 KMT2B H2AC14 H2BC21 EP300 DPY30 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B ZFPM1 H2BC14 H2AJ KMT2A H2BC15 H2BC11 GATA1 HDAC1 MYL9 H3C15 PF4 NFE2 WDR5 H2BS1 SETD1B GP1BA SETD1A H2AZ1 ITGA2B H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 SIN3B H2BC3 RBBP5 H2BC1 ASH2L H2AC20 SIN3A TNRC6C MOV10 TNRC6A TNRC6B PRMT6 PRKCQ DEFECTIVE PAPSS2 CAUSES SEMD-PA%REACTOME%R-HSA-3560796.1 Defective PAPSS2 causes SEMD-PA PAPSS2 CHEMOKINE RECEPTORS BIND CHEMOKINES%REACTOME%R-HSA-380108.3 Chemokine receptors bind chemokines CXCL10 CXCL11 CXCL12 CXCL6 CXCL9 CXCL8 CCL13 CCL11 CXCL1 CXCL3 CXCL2 CXCL5 CXCR5 CXCR4 CXCR6 CXCR1 CXCR3 CXCR2 CCL19 CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 XCL2 XCL1 CX3CR1 CCL7 CCL5 CCL28 CCL27 CCL4 PF4 CCL3 CCL2 CCL1 CCR10 CCR1 CXCL13 CXCL16 XCR1 PPBP CCRL2 ACKR4 ACKR3 ACKR2 CX3CL1 CCL3L3 CCR9 CCR8 CCR7 CCR6 CCR5 CCR4 CCR3 CCR2 FASL CD95L SIGNALING%REACTOME%R-HSA-75157.2 FasL CD95L signaling FADD CASP10 FASLG FAS CASP8 NEF-MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS%REACTOME%R-HSA-164938.1 Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters CD4 AP2B1 AP1S2 AP1M2 AP1S1 AP1M1 AP1S3 AP1G1 nef B2M ARF1 HLA-A CD8B LCK AP2A1 PACS1 CD28 AP1B1 AP2A2 AP2S1 ATP6V1H AP2M1 MODULATION BY MTB OF HOST IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 76%9637628 Modulation by Mtb of host immune system UBB Rv2779c esxA UBA52 pstS1 UBC TLR2 MRC1 RPS27A B2M ptpA EPHA-MEDIATED GROWTH CONE COLLAPSE%REACTOME%R-HSA-3928663.3 EPHA-mediated growth cone collapse MYL6 MYH14 MYH11 MYL9 MYH10 NGEF MYH9 ROCK1 ROCK2 FYN MYL12B RHOA LYN YES1 LXRS REGULATE GENE EXPRESSION LINKED TO CHOLESTEROL TRANSPORT AND EFFLUX%REACTOME%R-HSA-9029569.1 LXRs regulate gene expression linked to cholesterol transport and efflux HDAC3 APOD ARL4C ABCG8 NR1H2 EEPD1 ABCG5 RXRA ABCG1 CETP RXRB AGO3 AGO4 AGO1 APOE AGO2 ABCA1 APOC4 NR1H3 KDM1A NCOA1 APOC2 APOC1 KDM4A GPS2 EP300 TBL1XR1 NCOR2 TNRC6C TBL1X MOV10 NCOR1 TNRC6A TNRC6B KDM1B KDM3A ALANINE METABOLISM%REACTOME DATABASE ID RELEASE 76%8964540 Alanine metabolism GPT GABA B RECEPTOR ACTIVATION%REACTOME%R-HSA-977444.3 GABA B receptor activation GNAL KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 ADCY9 GABBR2 GABBR1 GNG10 GNAI3 GNG12 GNAI1 GNG11 GNAI2 GNG13 GNAT3 GNB2 GNB1 GNB4 ADCY4 GNB3 ADCY3 ADCY2 GNB5 ADCY1 ADCY8 ADCY7 ADCY6 GNGT1 ADCY5 GNGT2 RECOGNITION OF DNA DAMAGE BY PCNA-CONTAINING REPLICATION COMPLEX%REACTOME DATABASE ID RELEASE 76%110314 Recognition of DNA damage by PCNA-containing replication complex POLD2 USP1 UBE2B POLE4 DTL RAD18 POLE2 POLE3 PCNA RBX1 UBA52 WDR48 UBB RFC5 UBC RFC3 RFC4 RFC2 RPS27A POLE RFC1 DDB1 RPA1 CUL4A RPA2 RPA3 POLD3 CUL4B POLD4 POLD1 RAC1 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013149 RAC1 GTPase cycle FARP1 GNA13 IQGAP3 ITGB1 CYFIP1 NCKAP1 TRIO TFRC NCF1 ARHGDIA NCF2 MCF2L SNAP23 VAV3 PAK3 NCF4 ARHGAP9 PLEKHG3 ARHGAP1 BRK1 ARHGAP39 ARHGAP4 VAV1 ARHGAP5 ARHGAP35 ARHGEF5 DOCK10 PREX1 GMIP PLD1 WAS ARHGAP42 IQGAP2 CIT BAIAP2L1 KALRN DOCK11 OPHN1 ARHGDIB ERBIN LBR EMD TMPO ALS2 FGD5 SWAP70 CHN2 ARAP2 RAB7A CHN1 ARAP3 CYBB CYBA MYO9B VRK2 LEMD3 WASL PIK3R1 VAV2 BCR IQGAP1 TIAM1 ARHGAP12 CDC42EP1 CDC42 PAK1 VAMP3 GARRE1 PAK6 AMIGO2 PKN2 NOXO1 ARHGAP17 PIK3R2 GIT1 PKN1 SLC1A5 ARHGAP15 GIT2 ARHGAP21 ABR FAM13B FAM13A RACGAP1 NHS VANGL1 DEPDC1B ABL2 NCKAP1L WASF1 SRGAP2 ARHGEF7 WASF2 EPHA2 YKT6 PAK4 FARP2 JAG1 CAV1 MCAM MCF2 BAIAP2 ARHGAP26 MPP7 ARHGAP32 DOCK6 TAGAP DIAPH3 DOCK5 ABI2 PLEKHG4 TAOK3 DOCK4 PLEKHG1 ABI1 NOXA1 PLEKHG6 NOX3 DOCK3 ESYT1 NOX1 DOCK9 SRGAP3 FERMT2 DOCK8 SRGAP1 DOCK7 SH3BP1 CDC42BPA KTN1 NISCH SPATA13 RAC1 WASF3 DOCK2 DOCK1 PIK3CA SOS1 DLC1 SYDE2 RASGRF2 ARHGAP44 RALBP1 ARHGAP45 ARHGEF25 TIAM2 ARHGAP22 ARHGAP20 PREX2 NGEF ARHGAP29 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 PAK5 ARHGAP33 ARHGAP31 ARHGAP30 ECT2 ARHGEF39 FMNL1 ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF15 ARHGEF19 ARHGAP10 ARHGEF4 SOS2 ARHGEF6 CYFIP2 WIPF1 WIPF2 WIPF3 PAK2 LAMTOR1 ARAP1 CDC42EP4 PIK3R3 PLD2 ARHGEF18 DEF6 PARD6A HDACS DEACETYLATE HISTONES%REACTOME DATABASE ID RELEASE 76%3214815 HDACs deacetylate histones HDAC3 H2AC17 H2AC12 H2AC21 H2AW H2AC19 KDM1A CHD4 CHD3 H2AC14 H2BC21 H2BU1 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 ARID4A H2BC14 H2BC15 HDAC8 BRMS1 H2BC11 H2AC1 PHF21A REST HDAC2 HDAC1 H3C15 MTA1 RBBP4 ARID4B RBBP7 MTA2 SAP30 MTA3 SUDS3 H2BC9 MBD3 H4C9 H2BC18 H2BC8 H2BC5 RCOR1 H2BC3 H2BC1 GATAD2B GATAD2A H2AC20 SAP30L SAP18 GPS2 TBL1XR1 NCOR2 HMG20B TBL1X NCOR1 HDAC10 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9694676.1 Translation of Replicase and Assembly of the Replication Transcription Complex PIK3R4 9b UVRAG MAP1LC3B CHMP4C CHMP4B CHMP3 CHMP4A CHMP2B CHMP2A CHMP6 CHMP7 BECN1 PIK3C3 rep ASSEMBLY OF THE HIV VIRION%REACTOME DATABASE ID RELEASE 76%175474 Assembly Of The HIV Virion UBB MVB12B UBC UBAP1 rev MVB12A gag-pol RPS27A vif NMT2 PPIA nef vpr vpu VPS28 VPS37C gag VPS37D VPS37A VPS37B UBA52 TSG101 env FURIN EICOSANOIDS%REACTOME%R-HSA-211979.1 Eicosanoids CYP4B1 CYP4F11 CYP4F12 CYP8B1 CYP4A11 CYP4F22 PTGIS TBXAS1 CYP4F2 CYP4F3 CYP4A22 CYP4F8 BIOSYNTHESIS OF A2E, IMPLICATED IN RETINAL DEGRADATION%REACTOME DATABASE ID RELEASE 76%2466712 Biosynthesis of A2E, implicated in retinal degradation NAPEPLD ANTIGEN PROCESSING-CROSS PRESENTATION%REACTOME%R-HSA-1236975.1 Antigen processing-Cross presentation TAP2 FCGR1B TAP1 CD207 SEC61A2 MRC2 SEC61A1 NCF1 SEC61G NCF2 SEC61B SNAP23 TAPBP NCF4 CYBB CYBA VAMP3 SEC22B UBA52 PDIA3 CALR HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E UBB UBC RPS27A ITGAV FCGR1A B2M HLA-A S100A1 CTSS HMGB1 TIRAP mip BTK porB TLR6 CTSL CD36 LNPEP PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 MYD88 PSMD5 VAMP8 PSMD2 PSMD3 LY96 FGB PSMD1 FGA PSMA5 PSMA6 CD14 PSMA3 TLR4 PSMA4 PSMA1 FGG PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 MRC1 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 STX4 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 CHUK PSMB8 PSMB9 SEM1 IKBKG PSMC5 PSMC6 PSMC3 PSMC4 TLR1 PSMC1 PSMC2 S100A9 S100A8 TLR2 ITGB5 SENSORY PROCESSING OF SOUND%REACTOME%R-HSA-9659379.1 Sensory processing of sound CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 TPRN PLS1 TMC1 KCNMA1 CAPZA1 MYO7A CAPZA2 TMC2 PCLO MYO3B BSN CASK MYO3A CACNA2D2 KCNQ4 SYP FSCN2 SYN1 EZR PCDH15 CABP2 USH1C CABP1 TWF2 LRRC52 TWF1 OTOF ESPNL EPB41L1 EPB41L3 KCNMB1 CDH23 OTOG XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 GSN STX1A WHRN RDX MYH9 LHFPL5 MSN ATP2B1 OTOGL CHRNA9 TMIE CHRNA10 USH1G KCNN2 MYO15A STRC SLC26A5 CACNA1D SPTAN1 SPTBN1 VAMP2 MYO1C CACNB2 SNAP25 RAB3A CAPZB DNAJC5 SLC17A8 GLUTAMATE AND GLUTAMINE METABOLISM%REACTOME DATABASE ID RELEASE 76%8964539 Glutamate and glutamine metabolism KYAT1 GLS GLUL RIMKLA RIMKLB PYCR1 GOT2 PYCR2 PYCR3 GLUD1 OAT GLUD2 GLS2 SIGNAL ATTENUATION%REACTOME DATABASE ID RELEASE 76%74749 Signal attenuation IRS1 INSR GRB10 IRS2 SHC1 MAPK1 SOS1 MAPK3 INS DOWNREGULATION OF ERBB2:ERBB3 SIGNALING%REACTOME%R-HSA-1358803.1 Downregulation of ERBB2:ERBB3 signaling RNF41 UBB NRG1 NRG2 UBA52 ERBB2 UBC USP8 RPS27A AKT2 AKT1 AKT3 VASOPRESSIN-LIKE RECEPTORS%REACTOME%R-HSA-388479.2 Vasopressin-like receptors OXT AVPR1A OXTR AVPR2 AVPR1B AVP TICAM1, RIP1-MEDIATED IKK COMPLEX RECRUITMENT%REACTOME%R-HSA-168927.3 TICAM1, RIP1-mediated IKK complex recruitment UBB UBE2V1 IKBKB CHUK UBC UBE2D2 UBE2D3 TICAM1 RPS27A IKBKG RIPK1 BIRC2 UBE2D1 UBA52 BIRC3 RIPK3 TRAF6 TLR3 UBE2N INTERLEUKIN RECEPTOR SHC SIGNALING%REACTOME DATABASE ID RELEASE 76%912526 Interleukin receptor SHC signaling CSF2 SHC1 PIK3CA SOS1 IL2RA INPP5D INPPL1 IL5RA IL2 CSF2RB IL3 IL2RG CSF2RA IL5 PIK3CB IL2RB IL3RA PIK3CD PIK3R1 JAK2 PIK3R3 JAK3 GAB2 PTPN6 JAK1 PIK3R2 FCGR3A-MEDIATED PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 76%9664422 FCGR3A-mediated phagocytosis V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV LPG1G2 CYFIP1 V5-4 NCKAP1 V5-1 ARPC4 SYK FGR ARPC5 FYN VAV3 V5-6 HCK MAPK1 BRK1 VAV1 IGLV3-19 ARPC2 ELMO2 ARPC3 MAPK3 WAS IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 MYH9 IGKV1-5 ACTR2 MYO9B WASL VAV2 IGLV IGHG3 CDC42 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 NCK1 ABL1 IGHV4-59 NCKAP1L WASF1 IGLV2-11 NCKIPSD WASF2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MYO1C IGKV3-15 BAIAP2 IGKV3-11 V2-8 ABI2 IGLV7-43 ARPC1B ABI1 ACTG1 IGKV1D-16 IGKV1D-12 LYN YES1 IGLV1-51 IGLV2-23 IGKV3-20 PTK2 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 MYO5A BTK ACTB CD3G ARPC1A ELMO1 CRK CYFIP2 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 TGF-BETA RECEPTOR SIGNALING ACTIVATES SMADS%REACTOME%R-HSA-2173789.1 TGF-beta receptor signaling activates SMADs SMAD7 SMAD4 SMAD3 SMURF2 UBE2M UBA52 USP15 NEDD4L XPO1 UCHL5 UBB UBC RPS27A MTMR4 PMEPA1 PPP1CC BAMBI PPP1CB STRAP STUB1 PPP1R15A TGFB1 PPP1CA SMURF1 TGFBR1 FURIN TGFBR2 CBL FKBP1A SMAD2 NEDD8 FGFR1C LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190373 FGFR1c ligand binding and activation FGF23 FGF1 FGF2 FGF4 FGF6 ANOS1 FGF9 FGF20 KERATINIZATION%REACTOME DATABASE ID RELEASE 76%6805567 Keratinization DSG2 DSC1 CAPNS1 CAPN1 KRT1 PCSK6 FURIN PPL PI3 JUP LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRTAP17-1 KRT8 KRT7 KRT5 LCE1E LCE1F LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 SPRR2E FLG SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 SPRR2A SPRR2B SPRR2D ST14 CDSN KRTAP16-1 KRTAP8-1 SPRR1A SPRR1B KRTAP26-1 DSP KRT24 KRT23 KRT20 CASP14 KRT28 LCE5A KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 DSG1 KRTAP9-4 PKP4 KRTAP9-3 KRTAP9-2 KRTAP15-1 KRTAP9-1 KRT35 KRT34 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 KRT37 KRT36 LCE6A IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B KRTAP2-4 KRTAP2-3 KRTAP2-2 KRTAP2-1 KRT13 KLK13 KLK14 KRT12 KRT10 LCE3E KLK12 PERP KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 KRTAP3-1 TGM5 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 KRT78 KAZN KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 PKP3 SPINK9 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 KRTAP4-1 LELP1 KRTAP12-1 KRTAP12-3 KRTAP4-9 KRTAP12-2 KRTAP4-8 KRTAP4-7 KRTAP12-4 KRTAP4-6 KRTAP4-5 KRTAP22-1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 KRTAP5-9 CELA2A KRTAP5-8 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRT80 KRTAP21-2 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 PKP1 KRTAP10-9 KRTAP6-3 KRTAP10-8 KRTAP21-1 DSG3 INTESTINAL HEXOSE ABSORPTION%REACTOME%R-HSA-8981373.1 Intestinal hexose absorption SLC5A1 SLC2A5 SLC2A2 RSC1A1 GLYCEROPHOSPHOLIPID CATABOLISM%REACTOME DATABASE ID RELEASE 76%6814848 Glycerophospholipid catabolism PNPLA7 GDE1 GDPD1 GDPD3 PNPLA6 ENPP6 GDPD5 PROTEIN LOCALIZATION%REACTOME DATABASE ID RELEASE 76%9609507 Protein localization TOMM22 PEX26 CHCHD4 CHCHD5 CHCHD2 CHCHD3 DDO SCP2 CHCHD7 PEX19 NUDT19 LONP2 MPV17 PHYH CMC4 CMC2 PAM16 ECH1 BCS1L GNPAT ACOT2 COX17 PEX11B APP ATP5MC1 SEC61G TIMM50 SEC61B BAG6 IDE PITRM1 GRPEL1 LDHD GRPEL2 HACL1 CYC1 TOMM70 HAO2 COA4 OTOF DNAJC19 FIS1 EPHX2 NOS2 CHCHD10 TYSND1 TIMM44 TIMM10B CS COQ2 PXMP4 EMD ACO2 HSCB STX1A CROT TAZ SERP1 TIMM17A TIMM17B GET1 GET3 COA6 ABCD2 GET4 ABCD3 CAMLG TIMM23 TOMM20 TIMM22 PEX2 TIMM21 PEX1 PEX7 SLC25A17 ACOX1 PEX6 AGPS ACOX3 FXN PEX3 NDUFB8 TOMM40 TIMM9 USP9X TIMM13 TIMM10 ATP5F1A ATP5F1B UBL4A PEX16 ATAD1 TIMM8B TIMM8A MTX2 IDH3G SGTA PEX10 PEX12 GDAP1 UBA52 SLC25A4 GFER PEX13 PEX14 SLC25A6 DHRS4 NUDT7 TOMM7 CRAT TOMM5 TOMM6 UBB UBC RPS27A HAO1 VAPA IDH1 HSPA9 HMGCL HSD17B4 ACOT8 EHHADH DECR2 ACAA1 ACBD5 UBE2D2 ACOT4 UBE2D3 COX19 OTC BAAT UBE2D1 CAT AMACR ACOX2 PIPOX SLC27A2 VDAC1 PRNP VAMP2 DAO PXMP2 STX5 PMPCB PMPCA ABCD1 SLC25A12 SAMM50 AGXT MTX1 GSTK1 SLC25A13 PAOX HSPD1 PECR ZFAND6 HMOX1 TRANSCRIPTIONAL ACTIVATION OF P53 RESPONSIVE GENES%REACTOME%R-HSA-69560.2 Transcriptional activation of p53 responsive genes TP53 PCBP4 CDKN1A ZNF385A SCAVENGING OF HEME FROM PLASMA%REACTOME DATABASE ID RELEASE 76%2168880 Scavenging of heme from plasma V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 HP IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 CD163 IGLV7-43 HPR IGKV1D-16 HPX IGKV1D-12 IGHA1 IGHA2 IGLV1-51 AMBP IGLV2-23 IGKV3-20 JCHAIN IGHV4-34 HBB IGHV1-2 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 LRP1 APOA1 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 ALB IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 HBA2 APOL1 V1-16 V1-13 IGHV1-69 FORMATION OF INCISION COMPLEX IN GG-NER%REACTOME%R-HSA-5696395.1 Formation of Incision Complex in GG-NER ERCC4 ERCC1 PIAS1 ERCC5 SUMO1 SUMO3 SUMO2 DDB2 RBX1 CCNH UBA52 UBB GTF2H1 GTF2H2 UBC GTF2H3 GTF2H4 RPS27A CETN2 RNF111 GTF2H5 CDK7 PARP1 ERCC3 ERCC2 PARP2 DDB1 MNAT1 USP45 XPA RAD23A RPA1 CUL4A RPA2 CHD1L RAD23B UBE2V2 RPA3 XPC CUL4B PIAS3 UBE2N UBE2I DEFECTIVE CP CAUSES ACERULOPLASMINEMIA (ACERULOP)%REACTOME DATABASE ID RELEASE 76%5619060 Defective CP causes aceruloplasminemia (ACERULOP) CP SLC40A1 REGULATION BY C-FLIP%REACTOME%R-HSA-3371378.1 Regulation by c-FLIP FADD FASLG FAS CASP8 TRADD TNFSF10 TNFRSF10B RIPK1 TNFRSF10A TRAF2 TRIF-MEDIATED PROGRAMMED CELL DEATH%REACTOME%R-HSA-2562578.1 TRIF-mediated programmed cell death FADD TICAM2 LY96 RIPK3 TICAM1 CD14 TLR4 CASP8 RIPK1 FRS-MEDIATED FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654700 FRS-mediated FGFR2 signaling HRAS FGF1 FGF2 FGF3 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF7 FGF9 FGF20 FGF23 FGF22 FRS2 FGF16 FGF18 FGF10 STEROLS ARE 12-HYDROXYLATED BY CYP8B1%REACTOME DATABASE ID RELEASE 76%211994 Sterols are 12-hydroxylated by CYP8B1 CYP8B1 PTGIS CYTOSOLIC IRON-SULFUR CLUSTER ASSEMBLY%REACTOME%R-HSA-2564830.2 Cytosolic iron-sulfur cluster assembly RTEL1 CIAO3 NUBP1 NUBP2 BRIP1 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B ERCC2 ABCB7 POLD1 MUSCLE CONTRACTION%REACTOME DATABASE ID RELEASE 76%397014 Muscle contraction DYSF ATP2A1 SLC8A1 MYL6B ACTG2 SLC8A2 CALD1 ANXA6 MYLK MYL10 NOS1 ANXA2 CAV3 GUCY1A2 TPM2 GUCY1A1 TPM1 FKBP1B SORBS1 SORBS3 MYLPF KCNJ11 ACTA2 MYL5 MYL7 VCL MYL12A ATP1B3 STIM1 ATP1B2 ATP1B1 ORAI2 ORAI1 CACNA2D2 ITPR1 ITPR2 ITPR3 SRI CACNG8 ATP2B4 ATP2B3 CACNG4 ATP2B2 FXYD4 ATP2B1 FXYD3 FXYD2 FXYD1 SLC8A3 FXYD7 FXYD6 PRKACA HIPK1 PAK1 SCN11A GATA4 CALM1 TRDN TPM4 MYL6 SCN10A MYL9 TPM3 ATP1A4 ATP1A3 ATP1A2 ATP1A1 KCNK18 AKAP9 SLN CACNB1 CACNB2 TMOD3 CAMK2B CAMK2D CAMK2A CAMK2G TMOD1 HIPK2 ACTN3 TMOD4 KCNK12 TMOD2 KCNK15 MYL4 MYL1 MYL2 MYL3 ITGA1 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 DMPK ANXA1 NEB FGF14 FGF13 FGF12 FGF11 KCNK5 MYBPC3 MYBPC1 WWTR1 MYBPC2 TNNC1 SCN1B TNNC2 SCN1A MYH3 TNNT1 TNNT2 TNNT3 MYH8 MYH6 TTN CACNG6 CACNG7 TRPC1 TNNI1 TLN1 TNNI2 ASPH DMD TNNI3 ACTN2 KCNIP1 KCNIP2 KCNIP3 MYL12B KCNIP4 DES SCN3B TCAP KCNH2 SCN3A RANGRF PLN KCNK10 SCN2A SCN2B KCNK13 KCNK16 KCNK17 KCNQ1 KCNK6 KCNK7 KCNK9 SCN9A KCND1 KAT2B KCND2 KCND3 SCN8A CACNA1C MYH11 KCNJ2 KCNJ4 PXN KCNJ12 KCNJ14 SCN5A SCN4A KCNK1 SCN4B KCNK2 KCNK3 KCNK4 SCN7A AHCYL1 VIM RYR1 RYR2 PAK2 NPPC NPR1 RYR3 NPR2 NPPA CLIC2 TBX5 NKX2-5 CORIN ABCC9 GUCY1B2 GUCY1B1 TRIM72 ITGB5 ATP2A3 LMOD1 ATP2A2 TRANSPORT OF ORGANIC ANIONS%REACTOME DATABASE ID RELEASE 76%879518 Transport of organic anions SLC16A2 ALB SLCO1C1 SLCO4A1 SLCO4C1 SLCO1B1 SLCO2A1 SLCO1A2 SLCO2B1 AVP SLCO1B3 THE NLRP3 INFLAMMASOME%REACTOME%R-HSA-844456.5 The NLRP3 inflammasome RELA PSTPIP1 CASP1 SUGT1 NFKB2 P2RX7 TXNIP APP PYCARD NLRP3 NFKB1 MEFV PANX1 TXN hly HSP90AB1 HMOX1 GLYOXYLATE METABOLISM AND GLYCINE DEGRADATION%REACTOME%R-HSA-389661.6 Glyoxylate metabolism and glycine degradation OGDH GLDC PDHB GCSH DDO DLAT PDHA2 PDHX PDHA1 AGXT2 GOT2 HOGA1 DLD GRHPR DAO PXMP2 LIPT1 DLST LIAS DHTKD1 DBT BCKDHA BCKDHB AMT HAO1 PRODH2 GNMT ALDH4A1 NDUFAB1 AGXT INHIBITION OF SIGNALING BY OVEREXPRESSED EGFR%REACTOME DATABASE ID RELEASE 76%5638303 Inhibition of Signaling by Overexpressed EGFR HBEGF AREG TGFA EGFR EREG BTC EGF EPGN SIGNALING BY PLASMA MEMBRANE FGFR1 FUSIONS%REACTOME%R-HSA-8853336.1 Signaling by plasma membrane FGFR1 fusions ERLIN2 FGFR1 BAG4 MANIPULATION OF HOST ENERGY METABOLISM%REACTOME%R-HSA-9636667.2 Manipulation of host energy metabolism esxA PGK1 ENO1 NUCLEOBASE CATABOLISM%REACTOME%R-HSA-8956319.1 Nucleobase catabolism SAMHD1 AGXT2 GDA DPYS NT5C2 NUDT5 PNP DNPH1 TYMP NT5C UPP2 NT5M NT5E NUDT16 UPP1 NUDT15 ENTPD2 ENTPD1 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD5 ENTPD8 UPB1 NT5C1A NT5C1B DPYD ADPRM ITPA XDH FCGR3A-MEDIATED IL10 SYNTHESIS%REACTOME%R-HSA-9664323.1 FCGR3A-mediated IL10 synthesis V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV IL10 LPG1G2 V5-4 V5-1 SYK FGR FYN V5-6 HCK IGLV3-19 ITPR1 ITPR2 ITPR3 PRKX IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 PRKACA IGHG4 IGHG1 IGHG2 CALM1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN YES1 IGLV1-51 IGLV2-23 IGKV3-20 PRKAR2B IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 CREB1 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 FCGR2A PLCG1 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A CD3G ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 AHCYL1 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 PLCG2 DEVELOPMENTAL BIOLOGY%REACTOME DATABASE ID RELEASE 76%1266738 Developmental Biology CREBBP CBFB RUNX1 DHH EPHB6 MYL12A EFNB2 EFNB1 SDCBP EFNB3 FYN PAK3 EPHB2 MAPK1 EPHB1 EPHB4 EPHB3 EZR MAPK3 RDX MSN ALCAM DPYSL4 DPYSL5 RPL4 SCN11A DPYSL2 RPL5 DPYSL3 RPL30 RPL3 HOXA2 UNC5A RPL32 UNC5B RPL31 UNC5C RPL34 UNC5D RPLP1 ISL1 RPL10L MYL6 RPLP0 SCN10A RPL10A MYL9 RPL8 AGAP2 RPL6 RPL7 FLRT3 UPF3A RPS4X L1CAM RPS15 RET RPL7A CHL1 RPS14 UPF2 RPS17 LYPLA2 RPS16 DSCAML1 RPL18A ZSWIM8 RPS19 FARP2 RPS18 SEMA5A RPL36AL RPL36 PLXND1 RPL35 ITGA2B RPLP2 MSI1 RPL38 PLXNC1 RPL37 MAP2K1 SEMA6A RPS11 RPL39 MAP2K2 SEMA6D RPS10 CACNB1 RPS13 CACNB2 RPS12 CACNB3 RPS9 CACNB4 RPS7 SEMA7A DSC1 SHC3 RPL21 NCBP1 PLXNA2 RPS8 PLXNA1 NCBP2 SRGAP3 RPS5 SRGAP1 RPL23 PLXNA4 RPL22 PLXNA3 PTPRC RPS6 DAB1 RPL13A RPSA LHX3 PTPRA RPS3A LHX2 RPL9P9 ITGA10 RPL37A RPL24 PLXNB3 RPL27 LHX4 ETF1 LHX9 CNTNAP1 RPL26 ITGB3 RPL29 PIK3CD RPL28 RPS4Y2 TREM2 ITGAV RPL10 NEO1 RPL12 ITGA2 RPL11 ITGA1 RPL36A RPS27L EVL ITGA5 RPS4Y1 MET GSPT2 ITGA9 GSPT1 RPS15A SEMA3A NTN4 RPL14 RPS3 SEMA3E RPL13 ABLIM1 RPS2 ABLIM2 RPL15 ABLIM3 RPL18 SEMA4A RPL17 SEMA4D NELL2 RPL19 NFASC RPL39L RPL41 RPS6KA4 KRT1 RPL35A DAG1 RPL23A SCN1B SCN1A RPL3L EPHA5 ELOB RPS26 EPHA4 ELOC RPS25 EPHA7 RPS28 EPHA6 RPS27 EPHA8 RPS29 SHTN1 RPL27A RPL22L1 KCNQ2 KCNQ3 RPS20 EPHA1 FAU TLN1 RPS21 RPL26L1 PFN1 EPHA3 RPS24 PFN2 RPS23 GRB7 EPHA10 GRIN2B MYL12B RRAS GRIN1 SCN3B SCN3A DLG1 VASP SIAH1 DLG3 ARTN CD24 H2AX DLG4 SCN2A SCN2B H2AB1 H2AC19 ROBO2 NRP1 ROBO1 CAP1 ACTB GFRA1 H2AC14 GFRA3 RGMB H2BC21 EP300 GFRA2 H2BU1 GFRA4 RGMA H3-3B H3C8 ENAH AKAP5 H2AC8 RELN PAK5 H2AC6 CAP2 H2AC7 CD72 H2BC17 RANBP9 SCN9A H2BC12 NRTN H2BC13 KAT2B DSCAM DOK2 H2BC14 TYROBP H2AJ DOK4 KAT2A DOK5 H2BC15 DOK6 SCN8A CACNA1D CACNA1C H2BC11 EFNA5 EFNA4 CACNA1H CACNA1G CACNA1I HDAC2 MYH14 MYH11 CACNA1S MYH10 H3C15 PRNP PSPN CNTN6 RBBP4 EFNA1 EFNA3 EFNA2 H2BS1 GDNF RBBP7 FES CNTN1 LDB1 RND1 H2AZ1 HJV H2BC9 SCN5A GAP43 H2AZ2 DCX SCN4A H4C9 H2BC8 SHANK3 H2BC5 SCN4B LAMA1 H2BC3 CRMP1 SLIT1 H2BC1 SCN7A SLIT3 DEK NCAM1 SLIT2 PDLIM7 H2AC20 CLASP2 MAPK12 MAPK13 SLC2A2 ONECUT3 ONECUT1 HNF4G NEUROD1 NKX6-1 NKX2-2 PAX4 PDX1 PAX6 HNF1B HNF1A MAFA PPL RFX6 INSM1 PTF1A HDAC3 FOXA3 FOXA2 NEUROG3 GCK CSNK2A1 CSNK2A2 JUP VAV3 CSNK2B KALRN LCE1A LCE1B LIPJ LIPN LIPM PRSS8 LIPK KRT4 KRT3 KRT2 KRTAP17-1 NFKB1 KRT8 KRT7 KRT5 LCE1E LCE1F HSP90AB1 LCE1C KRT9 LCE1D LCE2B LCE2C LCE2A KRTAP4-11 LORICRIN KRTAP20-1 KRTAP20-2 SPRR2E FLG SPRR2F SPRR2G KRTAP10-10 KRTAP10-11 KRTAP10-12 KRTAP27-1 KLK5 KLK8 EVPL KRT33B KRTAP5-10 KRT33A KRTAP5-11 STAT3 SPRR2A SPRR2B SPRR2D ARHGEF28 ST14 ARPC1B CDSN KRTAP16-1 ACTG1 KRTAP8-1 CFL1 LYN SPRR1A YES1 SPRR1B KRTAP26-1 LIMK2 KRT24 LIMK1 PTK2 KRT23 KRT20 CASP14 KRT28 LCE5A KRT27 KRT26 KRT25 KRTAP1-5 KRTAP1-4 KRTAP1-3 KRTAP1-1 KRTAP9-7 KRTAP9-6 KRTAP9-4 KRTAP9-3 KRTAP9-2 KRTAP15-1 KRTAP9-1 KRT35 KRT34 FABP4 SDC2 KRT32 KRT31 KRTAP9-9 KRTAP9-8 KRT39 KRT38 GPC1 KRT37 PLIN1 KRT36 LCE6A IVL KRTAP25-1 SPRR3 CSTA LCE2D LCE3C LCE3D SHC1 LCE3A GAB1 LCE3B CTNNA1 KRTAP2-4 PIK3CA KRTAP2-3 PLCG1 KRTAP2-2 SOS1 KRTAP2-1 KRT13 KLK13 KLK14 AGRN KRT12 KRT10 LCE3E KLK12 KRT19 KRT18 KRT17 KRT16 LCE4A KRT15 KRT14 KRTAP24-1 TGM1 KRTAP3-3 KRTAP3-2 KRTAP3-1 TGM5 KRT6C KRT6B RPTN KRT6A KRT71 KRTAP13-2 KRTAP13-1 KRTAP13-4 KRTAP13-3 SPINK6 SPINK5 KRT79 ST8SIA4 KRT78 KAZN KRT77 KRT76 KRT75 KRT74 KRT73 KRT72 PKP2 ST8SIA2 PKP3 SPINK9 DSC2 DSC3 KRTAP23-1 KRT40 KRTAP4-4 KRTAP4-3 KRTAP4-2 KRTAP4-1 LELP1 KRTAP12-1 KRTAP12-3 KRTAP4-9 KRTAP12-2 KRTAP4-8 KRTAP4-7 KRTAP12-4 KRTAP4-6 KRTAP4-5 KRTAP22-1 EPAS1 TCHH KRTAP5-3 KRTAP5-2 KRTAP5-1 KRTAP10-1 KRTAP11-1 KRTAP5-9 CELA2A KRTAP5-8 FOXO1 KRTAP5-7 KRTAP5-6 KRTAP5-5 KRTAP5-4 KRTAP19-2 AKT2 KRTAP19-1 KRTAP19-4 KRTAP19-3 KRTAP19-6 KRTAP19-5 KRTAP19-8 KRTAP19-7 DSG4 KRT82 KRT81 KRT80 KRTAP21-2 KRTAP21-3 KRTAP29-1 KRT86 KRT85 KRT84 KRT83 KRTAP6-2 KRTAP6-1 KRTAP10-3 KRTAP10-2 KRTAP10-5 KRTAP10-4 KRTAP10-7 KRTAP10-6 PKP1 KRTAP10-9 KRTAP6-3 KRTAP10-8 KRTAP21-1 DSG3 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL4A5 COL6A3 COL6A6 COL6A5 ITGB1 TRIO YY1 MEF2A MEF2C RPS6KA3 RPS6KA5 RPS6KA2 ARHGAP39 RPS6KA1 ARHGAP35 LGI1 LGI4 LGI3 LGI2 ADAM11 ADAM22 STX1B CACNG8 ADAM23 CACNG2 CACNG3 STX1A CACNG4 CEBPB CSF3R SPI1 VAV2 GFI1 TAL1 TIAM1 CEBPA KMT2A GRB10 DSG2 CEBPE FLI1 KLF5 PIK3R2 ABL2 ADIPOQ SRGAP2 PAK4 CCND3 TFDP1 TFDP2 CDK4 E2F1 MAML2 MAML1 RBPJ MYC TEAD1 MAML3 YAP1 NOTCH1 SRC LEF1 FOXO3 HES1 WWTR1 SMAD4 SMAD3 SNW1 CTNNB1 MAMLD1 MEF2D PPARGC1A TNF MAG NGEF PSEN2 APH1A APH1B PKNOX1 NR2F2 PBX1 NANOG MED19 CTCF MED18 MED11 POU5F1 MED29 MED28 MED22 MED21 ZNF467 WT1 PSENEN NAB1 ARHGEF11 NAB2 PIAS2 UTRN ARHGEF12 MBP ADGRV1 ZNF638 SRY PAXIP1 EGR2 MED13L FOXD3 NCOA3 MPZ POU3F1 SOS2 POU3F2 ADGRG6 ZIC3 DPPA4 LAMA2 HMGCR HOXA3 HOXA1 HOXA4 MED9 SOX10 HOXB4 HOXB3 HOXB2 HOXB1 HOXD1 NCOA1 PRDM14 MED1 ZSCAN10 HOXC4 NCOA2 WNT10B CDK19 HOXD4 SMARCD3 CHD9 HOXD3 NCOA6 ZNF335 SALL1 HELZ2 SALL4 TBL1XR1 TGS1 MAFB CARM1 PAGR1 AMH TBL1X CEBPD PTGDS EBF1 ADIRF PRX DRP2 DMRT1 SCD5 LIN28A KDM6A THRAP3 FAM120B MEIS1 PMP22 TRPC7 TRPC6 MAP2K6 TRPC3 PTPN11 MAPK8 CDK5R1 HIF3A CUL2 EZH2 EED SUZ12 JUN PERP CNOT6 CNOT9 CCNC HSP90AA1 ERBB2 MYB CDK8 MYO9B PRKACA GATA4 GATA2 IAPP ABL1 WNT1 CDK5 KIF4B KIF4A UBA52 AJUBA UBB UBC RPS27A CLASP1 RAC1 MYO10 DOCK1 NR5A1 RXRA RARA PPARG PPARA LEP POLR2A POLR2B POLR2C RPS6KA6 POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L CLTA AP2A1 VLDLR PCSK6 AP2A2 PCK1 KLF4 AP2M1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 CDH2 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 ANGPTL4 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 LPL PSME2 PSMD10 PSMB11 PSMD12 AP2S1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 AP2B1 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RAP1GAP PSMC2 SMAD2 LEFTY1 FOXH1 GDF1 ACVR1B ACVR2B ACVR2A CFC1 DRAP1 ACVR1C TDGF1P3 LEFTY2 TDGF1 DAND5 NODAL CER1 MED16 MED15 MED17 MED12 MED14 MED13 MED10 MED27 MED26 MED23 MED25 MED24 MED20 DSP DSG1 PKP4 ITSN1 AKT3 TRPC5 TRPC4 TRPC1 PIP5K1C KMT2D KMT2C CXCR4 MED30 MED31 ARPC1A CLTB EGFR CLTCL1 SMARCA4 CXCL12 ARPC4 ARPC5 ARPC2 ARPC3 TCF3 ACTR2 SPTB MED8 MED4 MED6 MED7 RARG ASH2L TCF12 RARB CAPNS1 CAPN1 ADAM10 ANK2 ANK3 ANK1 PCGF2 PSEN1 SPTBN4 NCSTN SPTBN5 COL9A1 COL9A3 COL9A2 EIF4A3 SPTBN2 CASC3 LAMC1 MAGOH SH3KBP1 MMP2 RBM8A MMP9 UPF3B MAGOHB RNPS1 FURIN DCC PITPNA NTN1 LAMB1 WDR5 RBBP5 SH3GL2 IRS2 PIK3CB SOX2 FGF2 SOX9 FGF9 FRS2 GAB2 SPTA1 FGF10 PI3 SIAH2 SLC2A4 DNM1 DNM2 DNM3 HSPA8 MYH9 CLTC WASL PIK3R1 CDC42 PAK1 NCK2 PAK6 SPTAN1 GIT1 INS SPTBN1 NCK1 USP33 ARHGEF7 EPHA2 GSK3B AKT1 PRKCA MAPK7 PABPC1 NCOR2 CREB1 NCOR1 MAPK14 MAPK11 PRKCQ EIF4G1 CDKN1A CDK2 CYP51A1 PRKACG PRKACB SREBF2 RBX1 RHOC RHOB CD36 PLXNB1 PRKAR2A NUMB NTN3 NRP2 CNTN2 CDH4 BNIP2 NRCAM CTNNA2 CDON SPAG9 MYOG MEF2B IL6R MYOD1 MYF6 TCF4 NCAN CDH15 MYF5 ROCK1 ROCK2 HRAS RELA RASA1 NRAS DOK1 TGFB1 PIK3R3 RHOA PPP3CB FGFR3 MUTANT RECEPTOR ACTIVATION%REACTOME%R-HSA-2033514.1 FGFR3 mutant receptor activation FGF23 FGF16 FGF1 FGF18 FGF2 FGF4 FGFR3 FGF9 FGF20 RND2 GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9696270 RND2 GTPase cycle UHRF1BP1L DST TXNL1 VANGL1 FNBP1 DEPDC1B DLG5 FRS3 EPHA2 PLXND1 CAV1 PRAG1 TFRC ARHGAP1 TNFAIP1 ARHGAP5 LRRC1 ALDH3A2 ARHGAP35 NUDC MUC13 RBMX FAM83B ANKRD26 SCRIB PTPN13 CKAP4 KTN1 NISCH VANGL2 GOLGA3 UBXN11 KCTD13 KIDINS220 DSG1 PKP4 LEMD3 PIK3R1 RND2 FRS2 KIF14 WDR6 PIK3R2 REMOVAL OF THE FLAP INTERMEDIATE%REACTOME DATABASE ID RELEASE 76%69166 Removal of the Flap Intermediate POLD2 PRIM2 PRIM1 POLA1 POLA2 PCNA RPA1 RPA2 RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 SYNTHESIS OF PE%REACTOME DATABASE ID RELEASE 76%1483213 Synthesis of PE CHKA LPIN2 SELENOI LPIN3 PISD ETNPPL PHOSPHO1 ETNK2 ETNK1 CEPT1 CHKB PCYT2 LPIN1 RHO GTPASE EFFECTORS%REACTOME%R-HSA-195258.4 RHO GTPase Effectors PRKCB DIAPH1 ITGB1 CYFIP1 NCKAP1 ARPC4 NCF1 NCF2 ARPC5 PAK3 NCF4 MAPK1 BRK1 ARPC2 ARPC3 MAPK3 WAS KDM1A KIF5B KIF5A YWHAE PPP1CB CYBB CYBA ACTR2 PPP2R1A YWHAG KLC1 NOXO1 PPP1R12A KLC4 KLC3 KLC2 MYL6 CDC25C MYL9 ABL1 NCKAP1L DYNLL1 WASF1 SRGAP2 CKAP5 NCKIPSD WASF2 KIF18A MAPRE1 DVL1 BAIAP2 DVL3 PAFAH1B1 DYNC1I2 DIAPH3 ABI2 ABI1 CENPF NOXA1 NOX3 NOX1 CDH1 CLASP1 DYNC1H1 RAC1 NDE1 PLK1 EVL ZW10 KIF2A KLK2 WASF3 CFTR KIF2C KIF2B AR RPS27 CTNNB1 CENPE PFN1 PFN2 MYL12B H2AX LIN7B DLG4 H2AB1 H2AC19 ACTB H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 SEC13 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ CTTN RHOQ H2BC15 NUP107 PIN1 H2BC11 MYH14 MYH11 MYH10 H3C15 DYNC1I1 H2BS1 H2AZ1 H2BC9 ITGB3BP H2AZ2 H4C9 H2BC8 H2BC5 NUP160 NUP85 H2BC3 H2BC1 H2AC20 CLASP2 PIK3R4 NCOA2 PAK2 S100A9 S100A8 NUP133 PIK3C3 PPP2R1B PPP2R5E MYLK NUP43 RANBP2 MRTFA DAAM1 PPP2R5B CDCA8 IQGAP3 PPP2R5A SKA1 PPP2R5D SKA2 PPP2R5C NUP37 RHOG YWHAQ NUF2 YWHAH NUDC PPP2CA IQGAP2 CIT PPP2CB INCENP PKN3 CENPA CENPC PDPK1 FLNA CENPT MYH9 CENPU WASL CENPH IQGAP1 CENPI TAOK1 CENPK CDC42 PAK1 CENPL CENPM GOPC CALM1 PKN2 CENPN DYNLL2 PKN1 CENPO CENPP NCK1 CENPQ CENPS MEN1 CLIP1 MAD1L1 NDC80 NF2 YWHAB SPDL1 ARPC1B XPO1 ACTG1 CFL1 RANGAP1 PPP1R12B SRF LIMK2 PRKCD NSL1 LIMK1 PRKCA PTK2 CDC20 YWHAZ PPP1R14A KTN1 AURKB PRC1 PPP1CC KNL1 ROPN1 KLK3 DSN1 SCAI RCC2 ZWINT MAPK14 MAPK11 AHCTF1 KIF14 CDKN1B NDEL1 RHOD TAX1BP3 MIS12 CTNNA1 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L RTKN ZWILCH BTK RHOC RHOB KNTC1 SFN SGO1 SGO2 PMF1 RHPN1 RHPN2 BUB1B BUB3 MAD2L1 ARPC1A BUB1 KDM4C FMNL3 FMNL1 FMNL2 ROCK1 ROCK2 BIRC5 CYFIP2 WIPF1 WIPF2 WIPF3 RAC2 PRKCZ RHOA DVL2 HH MUTANTS ARE DEGRADED BY ERAD%REACTOME%R-HSA-5362768.2 Hh mutants are degraded by ERAD DERL2 ERLEC1 SHH OS9 SYVN1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 PSME3 PSME4 SEL1L PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 1%REACTOME DATABASE ID RELEASE 76%418592 ADP signalling through P2Y purinoceptor 1 GNG12 GNG11 GNG13 GNA14 GNB2 GNAQ P2RY1 GNB1 GNG3 GNA15 GNB4 GNG2 GNB3 GNG5 PLA2G4A GNG4 GNB5 GNG7 GNA11 GNG8 GNGT1 MAPK14 GNGT2 GNG10 SIGNALING BY ERBB2 KD MUTANTS%REACTOME%R-HSA-9664565.1 Signaling by ERBB2 KD Mutants NRG1 HSP90AA1 NRG2 NRG3 CDC37 HRAS NRG4 ERBB2 ERBIN SHC1 GAB1 PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 HBEGF EGFR EREG BTC TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION%REACTOME%R-HSA-975138.2 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7 8 or 9 activation TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 TLR7 MAPK8 NFKBIB FBXW11 IRAK4 SAA1 MYD88 TICAM2 LY96 TICAM1 CD14 TLR4 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 TLR9 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 PROTON-COUPLED MONOCARBOXYLATE TRANSPORT%REACTOME DATABASE ID RELEASE 76%433692 Proton-coupled monocarboxylate transport SLC16A3 EMB SLC16A7 BSG SLC16A1 SLC16A8 UCH PROTEINASES%REACTOME%R-HSA-5689603.2 UCH proteinases MCRS1 INO80 H2AC17 H2AC12 HCFC1 BARD1 H2AC21 YY1 BAP1 H2AW UCHL1 UCHL3 H2AC19 UCHL5 ACTB H2AC14 MBD5 H2AC8 MBD6 H2AC6 H2AC7 KDM1B H2AC1 PSMD8 NEDD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 SMAD7 PSMD2 PSMD3 OGT PSMD1 PSMA5 PSMA6 PSMA3 SENP8 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 USP15 PSMD13 PSMA7 PSMB10 PSMA8 FOXK2 PSMB6 FOXK1 PSMB7 PSMB4 H2AC20 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 RUVBL1 UBC PSMB8 NFRKB PSMB9 RPS27A ADRM1 SEM1 PSMC5 ASXL1 PSMC6 PSMC3 ASXL2 PSMC4 PSMC1 ACTR5 PSMC2 ACTL6A ACTR8 TGFB1 INO80C INO80B TGFBR1 INO80E INO80D TGFBR2 TFPT IRS-MEDIATED SIGNALLING%REACTOME%R-HSA-112399.3 IRS-mediated signalling GAB1 PIK3CA FLT3 SOS1 AKT2 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 NRAS FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 FLT3LG FRS2 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 PIK3C3 FGFR4 PIK3R2 FGF10 SIGNALING BY PDGFRA TRANSMEMBRANE, JUXTAMEMBRANE AND KINASE DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 76%9673767 Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants PIK3R1 STAT1 HRAS PDGFRA STAT3 PIK3CB PIK3CA SOS1 NRAS PIK3R2 DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (DUODENUM)%REACTOME DATABASE ID RELEASE 76%5655799 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum) SLC40A1 HEPH TOXICITY OF TETANUS TOXIN (TETX)%REACTOME DATABASE ID RELEASE 76%5250982 Toxicity of tetanus toxin (tetX) tetX VAMP2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCOSE-DEPENDENT INSULINOTROPIC POLYPEPTIDE (GIP)%REACTOME%R-HSA-400511.2 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ISL1 PCSK1 GPR119 DPP4 SPCS3 FFAR1 SPCS2 SPCS1 GIP SEC11A SEC11C GATA4 PAX6 G1 PHASE%REACTOME DATABASE ID RELEASE 76%69236 G1 Phase CCNE2 CCNE1 PPP2R1B ABL1 CDKN2A CDK2 RBL2 RBL1 E2F4 CCNH UBA52 E2F5 PPP2R3B CUL1 SKP2 LYN PPP2CA CDKN1C PPP2CB UBB RB1 CCND3 TFDP1 UBC CDK6 CCND2 TFDP2 CCND1 RPS27A CDK4 E2F1 CDK7 E2F2 E2F3 CDKN2D CDKN2C MNAT1 PPP2R1A PTK6 JAK2 CDKN2B CDKN1A CDKN1B SKP1 PPP2R2A CKS1B DEFECTIVE HEXA CAUSES GM2G1%REACTOME%R-HSA-3656234.1 Defective HEXA causes GM2G1 HEXA PLATELET SENSITIZATION BY LDL%REACTOME DATABASE ID RELEASE 76%432142 Platelet sensitization by LDL PPP2CA PPP2CB PPP2R1B PPP2R5E APOB PPP2R5B PTPN11 PLA2G4A PPP2R5A PPP2R5D PPP2R1A PPP2R5C FGR MAPK14 PECAM1 PTPN6 LRP8 UPTAKE AND FUNCTION OF ANTHRAX TOXINS%REACTOME DATABASE ID RELEASE 76%5210891 Uptake and function of anthrax toxins MAP2K4 MAP2K1 MAP2K7 MAP2K2 cya FURIN lef CALM1 pagA PDCD6IP LXRS REGULATE GENE EXPRESSION LINKED TO GLUCONEOGENESIS%REACTOME%R-HSA-9632974.1 LXRs regulate gene expression linked to gluconeogenesis PCK1 RXRA RXRB NRIP1 NR1H3 REGULATION OF ACTIVATED PAK-2P34 BY PROTEASOME MEDIATED DEGRADATION%REACTOME%R-HSA-211733.1 Regulation of activated PAK-2p34 by proteasome mediated degradation PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PAK2 PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 COSTIMULATION BY THE CD28 FAMILY%REACTOME%R-HSA-388841.3 Costimulation by the CD28 family PPP2R1B PPP2R5E MAPKAP1 PIK3CA TRAC CD3E PPP2R5B GRAP2 TRBC1 PPP2R5A LCK ICOSLG PPP2R5D PDCD1LG2 PPP2R5C CD28 CD274 TRBV12-3 TRAV29DV5 TRBV7-9 FYN PRR5 BTLA PAK3 TRAV19 TRAV8-4 VAV1 PPP2CA CD4 PPP2CB CD3G CD3D PDPK1 PTPN11 CD86 CD80 PPP2R1A RICTOR PIK3R1 CDC42 TRIB3 PAK1 PTPN6 PIK3R2 PDCD1 CTLA4 MAP3K14 AKT2 MLST8 AKT1 HLA-DQA2 HLA-DQA1 LYN MAP3K8 YES1 HLA-DRB5 HLA-DRB4 CSK MTOR HLA-DRB3 HLA-DRB1 PAK2 HLA-DPA1 HLA-DQB2 HLA-DQB1 THEM4 RAC1 HLA-DPB1 PIK3R3 HLA-DRA TNFRSF14 AKT3 BIOSYNTHESIS OF DPAN-3 SPMS%REACTOME DATABASE ID RELEASE 76%9025094 Biosynthesis of DPAn-3 SPMs ALOX5 PTGS2 ALOX15 ALOX12 DIGESTION%REACTOME DATABASE ID RELEASE 76%8935690 Digestion LIPF PNLIPRP1 PNLIPRP2 CEL PNLIPRP3 GUCY2C CLPS PNLIP CHIT1 MGAM CHIA GUCA2B SI AMY2A GUCA2A LCT AMY1A PIR AMY2B ALPI TREH AMY1B AMY1C BETA DEFENSINS%REACTOME%R-HSA-1461957.1 Beta defensins DEFB125 DEFB124 DEFB123 DEFB121 DEFB107B DEFB105B DEFB104B DEFB1 DEFB109B DEFB136 DEFB135 DEFB134 DEFB133 DEFB108B DEFB132 DEFB108C DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 DEFB130A CCR6 DEFB130B DEFB4B TLR2 CCR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 RUNX1 AND FOXP3 CONTROL THE DEVELOPMENT OF REGULATORY T LYMPHOCYTES (TREGS)%REACTOME DATABASE ID RELEASE 76%8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) IL2RA NFATC2 CBFB IL2 CTLA4 RUNX1 CR1 IFNG FOXP3 TNFRSF18 NON-CODING RNA METABOLISM%REACTOME DATABASE ID RELEASE 76%194441 Non-coding RNA Metabolism NUP42 NUP43 RAE1 RANBP2 NUP35 SNRPG NUP37 SNRPE SNRPF SNRPB GEMIN2 WDR77 CLNS1A GEMIN4 GEMIN5 PRMT5 GEMIN6 GEMIN7 GEMIN8 DDX20 SMN2 SNUPN SEC13 PHAX NUP107 NUP188 NUP210 NUP93 POM121 NUP205 SNRPD2 AAAS SNRPD1 SNRPD3 NUP160 POM121C NUP85 TPR NUP88 NUP155 NCBP1 NUP214 NUP153 NCBP2 TGS1 NUP62 NDC1 NUP133 NUP50 NUP54 MET RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 76%6806942 MET Receptor Activation HGF SPINT1 HPN MET HGFAC SPINT2 HDMS DEMETHYLATE HISTONES%REACTOME%R-HSA-3214842.3 HDMs demethylate histones H3C15 KDM5B H4C9 KDM6B KDM1A KDM4A KDM4B KDM5A PHF2 H3C8 KDM5C KDM5D KDM3B PHF8 UTY KDM2A KDM2B KDM4D ARID5B JMJD6 KDM1B RIOX2 KDM7A KDM6A KDM4C KDM3A LEWIS BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%9037629 Lewis blood group biosynthesis FUT9 B3GALT2 B3GALT1 ST3GAL4 B4GALNT2 ST6GALNAC6 ST3GAL3 ST3GAL6 FUT10 FUT11 B3GALT4 B3GALT5 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 ERBB2 REGULATES CELL MOTILITY%REACTOME DATABASE ID RELEASE 76%6785631 ERBB2 Regulates Cell Motility NRG1 NRG2 MEMO1 NRG3 NRG4 ERBB2 DIAPH1 EGF HBEGF EGFR EREG RHOA BTC ELECTRON TRANSPORT FROM NADPH TO FERREDOXIN%REACTOME%R-HSA-2395516.2 Electron transport from NADPH to Ferredoxin FDXR FDX1 FDX2 TRIGLYCERIDE BIOSYNTHESIS%REACTOME%R-HSA-75109.6 Triglyceride biosynthesis LPIN2 LPIN3 GK3P MOGAT3 MOGAT2 MOGAT1 GK2 AGMO GPAT2 DGAT2 GK DGAT1 GPAM LPIN1 DEFECTIVE SLC35A2 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2M (CDG2M)%REACTOME%R-HSA-5619072.1 Defective SLC35A2 causes congenital disorder of glycosylation 2M (CDG2M) SLC35A2 SHC-MEDIATED CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 76%5654719 SHC-mediated cascade:FGFR4 KLB HRAS FGF1 FGF2 FGF4 SOS1 FGF6 NRAS FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 FGFR4 PI3K AKT ACTIVATION%REACTOME%R-HSA-198203.3 PI3K AKT activation PIK3R1 NGF IRS1 IRS2 PIK3CB PIK3CA RHOA PIK3R2 NTRK1 MGMT-MEDIATED DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 76%5657655 MGMT-mediated DNA damage reversal MGMT SEALING OF THE NUCLEAR ENVELOPE (NE) BY ESCRT-III%REACTOME%R-HSA-9668328.1 Sealing of the nuclear envelope (NE) by ESCRT-III VPS4A TUBAL3 TUBB6 TUBB8 TUBA3E TUBB3 SPAST TUBB1 TUBB8B LEMD2 TUBA3D CC2D1B TUBA3C TUBA4A CHMP2B CHMP2A TUBA4B IST1 CHMP4C CHMP4B CHMP3 TUBA1A CHMP4A TUBA8 CHMP6 TUBA1C TUBB4B CHMP7 TUBA1B TUBB4A TUBB2B TUBB2A DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME DATABASE ID RELEASE 76%5688399 Defective ABCA3 causes SMDP3 ABCA3 SYNTHESIS OF DOLICHYL-PHOSPHATE MANNOSE%REACTOME%R-HSA-162699.1 Synthesis of dolichyl-phosphate mannose DPM1 DPM2 DPM3 PRE-NOTCH PROCESSING IN THE ENDOPLASMIC RETICULUM%REACTOME DATABASE ID RELEASE 76%1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum NOTCH2 NOTCH3 NOTCH4 POGLUT1 NOTCH1 POFUT1 AUTODEGRADATION OF CDH1 BY CDH1:APC C%REACTOME%R-HSA-174084.4 Autodegradation of Cdh1 by Cdh1:APC C FZR1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RA BIOSYNTHESIS PATHWAY%REACTOME%R-HSA-5365859.2 RA biosynthesis pathway RDH11 ADH1C ADH4 ADH1A CYP26A1 CRABP1 AKR1C3 DHRS3 CYP26B1 ALDH1A3 SDR16C5 CYP26C1 DHRS9 ALDH1A2 RDH10 RDH16 RDH5 DHRS4 RDH14 RDH13 ALDH8A1 ALDH1A1 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G1 CELL CYCLE ARREST%REACTOME%R-HSA-6804116.3 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CCNA1 CCNE2 CCNE1 TP53 PCBP4 CDK2 E2F1 E2F7 E2F8 ARID3A CDKN1A CDKN1B ZNF385A CCNA2 DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME%R-HSA-5619079.1 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 NOD1 2 SIGNALING PATHWAY%REACTOME DATABASE ID RELEASE 76%168638 NOD1 2 Signaling Pathway TAB1 CASP2 UBE2V1 CASP1 MAP2K6 CASP8 AAMP BIRC2 BIRC3 CARD9 CASP4 MAPK12 MAPK13 IKBKB CHUK CASP9 IKBKG TNFAIP3 NOD1 CYLD NOD2 MAPK14 MAPK11 ITCH IRAK1 IRAK2 RIPK2 TRAF6 UBE2N TAB3 MAP3K7 TAB2 HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 76%167287 HIV elongation arrest and recovery CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CCNK TCEA1 PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 76%1257604 PI3K AKT Signaling STRN GSK3A BMI1 KIT FYN MAPK1 TRIM27 MAPK3 PDGFB KDM1A PDGFRB HGF ERBB2 ESR2 RNF2 CD86 PPP2R1A CD80 TRIB3 HDAC5 HDAC7 PIK3R2 TRAT1 PIK3AP1 PHC2 PHC1 UBA52 PHC3 RCOR1 PML UBB UBC RPS27A PIK3CD RAC1 MET EREG ATF2 BTC SRC FOXO3 ESR1 TGFA FLT3 LCK PPARG CD28 CHD4 CHD3 PREX2 USP13 WWP2 RNF146 NEDD4 MKRN1 STUB1 FRK OTUD3 PSMD8 PSMD9 PSMD6 PSMD7 HDAC2 PSMD4 HDAC1 PSMD5 PSMD2 PSMD3 MTA1 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 PSMA4 RBBP7 PSMA1 MTA2 PSMA2 EPGN PSME3 MTA3 PSME4 PSME1 PSME2 MBD3 PSMD10 PSMB11 PSMD12 PSMD11 XIAP PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 GATAD2B PSMB6 GATAD2A PSMB7 BAD PSMB4 PSMB5 PSMB2 PSMB3 KLB PSMB1 IRS1 PSMF1 CHUK PSMB8 IRS2 PSMB9 PIK3CB FGF1 SEM1 PSMC5 FGF2 CASP9 PSMC6 FGF3 PSMC3 FGF4 SALL4 USP7 PSMC4 FGF6 FOXO6 PSMC1 FGF7 NR4A1 PSMC2 FGF9 RPS6KB2 FGF20 THEM4 FGF23 FGF22 INSR FLT3LG FRS2 PIP4K2A GAB2 PIP4K2B FGF16 FGF19 FGF18 PIP4K2C FGFR4 FGF10 HDAC3 PPP2R1B CBX8 MAPKAP1 CBX6 PPP2R5E CBX4 CBX2 NR2E1 PPP2R5B PPP2R5A PPP2R5D CSNK2A1 PPP2R5C CSNK2A2 PRR5 CSNK2B RHOG VAV1 PPP2CA PPP2CB PDPK1 PTPN11 RICTOR PIK3R1 INS FOXO4 RING1 EGF GSK3B EZH2 IER3 EED PIP5K1A PIP5K1B AKT1 SNAI1 SNAI2 MECOM PHLPP2 PHLPP1 ATN1 SUZ12 MAF1 JUN TNRC6C MOV10 CREB1 TNRC6A TNRC6B CDKN1A CDKN1B AKT3 TP53 GAB1 MDM2 PIK3CA AGO3 AGO4 AGO1 AGO2 PIP5K1C AREG IRAK4 REST MYD88 NRG1 NRG2 PTEN NRG3 NRG4 IL1RL1 IL33 HBEGF FOXO1 RPTOR EGFR AKT2 MLST8 SLC38A9 EGR1 TSC2 MTOR RRAGA PDGFRA RRAGC RHEB RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC2 TNKS2 TNKS PIK3R3 IRAK1 TRAF6 CD19 INTERLEUKIN-12 FAMILY SIGNALING%REACTOME%R-HSA-447115.5 Interleukin-12 family signaling MIF ANXA2 IL10 HSPA9 CAPZA1 STAT1 GSTO1 ARF1 MSN SOD1 CANX CDC42 TALDO1 RALA CA1 IFNG SNRPA1 JAK1 TCP1 PITPNA GSTA2 RPLP0 VAMP7 IL23A PPIA IL23R CNN2 STAT4 IL12B AIP TYK2 IL12RB1 PSME2 MTAP STAT3 CFL1 IL27 IL27RA PAK2 IL12A SOD2 P4HB LMNB1 SERPINB2 LCP1 HNRNPF IL6ST EBI3 BOLA2B HNRNPDL IL12RB2 RAP1B PDCD4 CRLF1 JAK2 HNRNPA2B1 PLC-GAMMA1 SIGNALLING%REACTOME DATABASE ID RELEASE 76%167021 PLC-gamma1 signalling NGF PLCG1 NTRK1 ELASTIC FIBRE FORMATION%REACTOME%R-HSA-1566948.2 Elastic fibre formation BMP7 GDF5 MFAP5 MFAP4 MFAP1 MFAP3 MFAP2 ITGA8 ITGB1 LTBP1 BMP4 FBN1 BMP2 LOXL3 LOXL4 LOXL1 LOXL2 ITGB3 VTN LOX FBN2 FBN3 ITGAV BMP10 ELN TGFB1 LTBP4 LTBP2 FBLN1 ITGA5 LTBP3 FBLN2 FBLN5 FURIN EFEMP2 EFEMP1 ITGB8 ITGB6 ITGB5 TGFB2 TGFB3 REGULATION OF NECROPTOTIC CELL DEATH%REACTOME%R-HSA-5675482.4 Regulation of necroptotic cell death OGT FASLG FAS CASP8 TRADD RIPK1 TRAF2 FADD BIRC2 SDCBP UBA52 BIRC3 XIAP FLOT1 TNFSF10 FLOT2 PDCD6IP TNFRSF10B TNFRSF10A PELI1 UBB MLKL HSP90AA1 CDC37 UBC RPS27A STUB1 CRMA RIPK3 SPI-2 CYTOSOLIC TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 76%379716 Cytosolic tRNA aminoacylation AARS1 MARS1 QARS1 HARS1 YARS1 WARS1 DARS1 GARS1 IARS1 NARS1 SARS1 PPA1 FARSA CARS1 TARS1 AIMP1 EEF1E1 FARSB VARS1 AIMP2 LARS1 RARS1 KARS1 EPRS1 GPCR LIGAND BINDING%REACTOME DATABASE ID RELEASE 76%500792 GPCR ligand binding FZD8 FZD7 SHH WNT11 DHH IHH FZD3 FZD5 ADM FZD6 PTH1R PTH2R RAMP2 RAMP3 PTH WNT3A SCTR GCG GHRH ADM2 RAMP1 IAPP CALCA CALCB CALCRL WNT1 WNT4 FZD1 CALCR GLP1R GLP2R GIP CRH PTH2 PTHLH VIP ADGRE5 ADGRE3 NPFFR2 APP OXTR NPFFR1 RXFP4 RRH HTR4 GRPR RXFP1 RXFP2 GNG10 RXFP3 EDNRA HTR6 EDNRB HTR7 GNG12 C3AR1 GNG11 OXER1 GNG13 PROK2 PROK1 GNB2 PTGDR CMKLR1 GNB1 UTS2R TAAR8 GNB4 TAAR9 TAAR6 GNB3 NPFF TAAR5 TAAR2 GNB5 GPR37L1 PDYN TAAR1 TRHR GNGT1 UTS2B KEL AGTR1 GNGT2 AGTR2 PTGFR LHB LPAR1 FPR1 LPAR2 LPAR3 FPR3 LPAR4 FPR2 C3 NLN MC2R C5 GALR3 GALR2 GALR1 NPBWR1 PENK GNG3 NPBWR2 PPY HCRT GNG2 CGA CCR10 GNG5 NTSR1 GNG4 NTSR2 GNG7 CCR1 GPR17 GNG8 NMB XCR1 PPBP NMBR MC1R LPAR5 LPAR6 NMS GPR183 PNOC NMU GNRH2 GNRH1 GPR18 PTGDR2 QRFP CX3CL1 MLN BRS3 MC4R GPR132 CCKAR OPN1LW CCR9 FFAR4 GNRHR CCR8 FFAR3 CCR7 FFAR2 FFAR1 CCR6 CCR5 CCR4 CCR3 OXGR1 CCR2 GPR39 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B GPR35 FSHB TACR2 GPBAR1 GPR31 TACR3 AVPR1A TACR1 F2 MC3R GAL ADRB3 CCKBR OPN1MW FSHR AVP RGR PTGER4 NPSR1 OPRD1 CCL13 NPB CCL11 PLPPR1 PLPPR2 GRP PTGER1 PLPPR3 PTGER2 PLPPR4 PTAFR PTGER3 FZD4 PLPPR5 CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R RHO CCL19 PRLH CCL17 GPHA2 CCL16 CCL25 P2RY12 P2RY13 P2RY10 CCL22 P2RY11 CCL21 CCL20 P2RY14 GPR55 GPR4 AGT GPR143 XK MT-RNR2 MC5R SAA1 F2RL1 CCL28 CCL27 F2RL2 PF4 F2RL3 GPHB5 CHRM2 CHRM3 CHRM1 GPR68 CHRM4 GPR65 NPY2R CHRM5 PMCH CXCL13 CXCL16 CYSLTR1 CYSLTR2 ADORA3 CCRL2 ADORA1 GHSR LHCGR F2R NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 CCL3L3 C5AR2 C5AR1 ADRB1 ADRB2 NTS MCHR1 MCHR2 KNG1 HCAR2 HCAR3 TAAR3P HRH1 HCAR1 HRH3 TBXA2R HRH2 PSAP HRH4 TAC3 DRD1 DRD2 TAC1 DRD3 DRD4 DRD5 OPN4 OPN3 HTR1E HTR1F HTR1D HTR1A HTR1B OPN5 CXCL10 PYY CXCL11 CXCL12 RLN2 RLN3 NMUR2 NMUR1 CXCL6 CXCL9 CXCL8 MLNR HTR2B HTR2C OXT ECE1 ADRA1D CXCL1 HTR2A ECE2 TRH CXCL3 ADRA1B CXCL2 ADRA1A CXCL5 LTB4R HEBP1 GPER1 BDKRB2 PRLHR BDKRB1 INSL3 QRFPR INSL5 TSHB PTGIR NPY5R GNRHR2 AVPR2 OPRM1 SSTR1 SSTR2 ADRA2C SSTR3 ADRA2B SSTR4 ADRA2A SSTR5 CORT ADORA2A ADORA2B XCL2 XCL1 CX3CR1 NPY4R OPRL1 P2RY6 CCL7 CNR2 P2RY4 CNR1 CCL5 P2RY2 CCL4 P2RY1 CCL3 S1PR1 CCL2 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HTR5A HCRTR2 TSHR APLN HCRTR1 KISS1 POMC OPN1SW SST ACKR4 ACKR3 ACKR2 ACKR1 CD55 WNT10B WNT5A ADCYAP1 ADCYAP1R1 FZD10 SMO CRHBP WNT10A FZD9 UCN3 UCN2 WNT9B WNT9A PTCH1 WNT8A WNT8B WNT7B WNT7A GNAS WNT6 WNT2 WNT3 PTCH2 UCN WNT2B ADGRE1 ADGRE2 WNT16 TAS2R60 TAS2R7 TAS2R9 TAS2R40 TAS2R8 TAS2R41 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM1 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS1R2 TAS2R1 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 VIPR1 GABBR2 VIPR2 CASR GABBR1 SCT TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R16 TAS2R38 TAS2R39 TAS2R19 GIPR CRHR1 GHRHR DEFECTIVE PGM1 CAUSES PGM1-CDG (CDG1T)%REACTOME%R-HSA-5609974.2 Defective PGM1 causes PGM1-CDG (CDG1t) PGM1 INTRACELLULAR SIGNALING BY SECOND MESSENGERS%REACTOME DATABASE ID RELEASE 76%9006925 Intracellular signaling by second messengers STRN KPNA2 GSK3A BMI1 KIT FYN MAPK1 TRIM27 MAPK3 PDGFB PRKX KDM1A PDGFRB HGF ERBB2 ESR2 RNF2 CD86 PPP2R1A CD80 PRKACA TRIB3 HDAC5 HDAC7 PIK3R2 TRAT1 PIK3AP1 PRKCG PHC2 PHC1 UBA52 PHC3 RCOR1 PML UBB PRKAR2B UBC RPS27A PIK3CD RAC1 MET EREG ATF2 BTC SRC FOXO3 ESR1 TGFA FLT3 LCK PPARG CD28 CAMKK1 CAMKK2 CHD4 CHD3 NBEA PREX2 USP13 WWP2 RNF146 NEDD4 MKRN1 STUB1 FRK OTUD3 PSMD8 PSMD9 PSMD6 PSMD7 HDAC2 PSMD4 HDAC1 PSMD5 PSMD2 PSMD3 MTA1 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 PSMA4 RBBP7 PSMA1 MTA2 PSMA2 EPGN PSME3 MTA3 PSME4 PSME1 PSME2 MBD3 PSMD10 PSMB11 PSMD12 PSMD11 XIAP PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 GATAD2B PSMB6 GATAD2A PSMB7 BAD PSMB4 PSMB5 PSMB2 PSMB3 KLB PSMB1 IRS1 PSMF1 CHUK PSMB8 IRS2 PSMB9 PIK3CB PRKCE FGF1 SEM1 PSMC5 FGF2 CASP9 PSMC6 FGF3 PSMC3 FGF4 SALL4 USP7 PSMC4 FGF6 FOXO6 PSMC1 FGF7 NR4A1 PSMC2 FGF9 RPS6KB2 FGF20 THEM4 FGF23 FGF22 INSR FLT3LG FRS2 PIP4K2A GAB2 PIP4K2B FGF16 FGF19 GRK2 FGF18 PIP4K2C FGFR4 FGF10 HDAC3 PPP2R1B CBX8 MAPKAP1 CBX6 PPP2R5E CBX4 CBX2 NR2E1 PPP2R5B PPP2R5A PPP2R5D CSNK2A1 PPP2R5C CSNK2A2 PRR5 CSNK2B PDE1B RHOG PDE1A VAV1 ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PDPK1 PTPN11 RICTOR PIK3R1 CALM1 INS FOXO4 RING1 EGF GSK3B EZH2 IER3 EED PIP5K1A PIP5K1B AKT1 SNAI1 SNAI2 MECOM PHLPP2 PRKCD PHLPP1 PRKCA ATN1 SUZ12 MAF1 CAMK2B CAMK2D JUN CAMK2A CAMK2G TNRC6C MOV10 CREB1 CAMK4 TNRC6A TNRC6B CDKN1A CDKN1B AKT3 TP53 GAB1 MDM2 PIK3CA PLCG1 PRKACG PRKACB ADCY9 PRKAR1B AGO3 PRKAR1A AGO4 AGO1 AGO2 PRKAR2A PIP5K1C PDE1C ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 AREG IRAK4 REST MYD88 NRG1 NRG2 PTEN NRG3 NRG4 IL1RL1 IL33 HBEGF FOXO1 RPTOR EGFR AKT2 MLST8 AHCYL1 SLC38A9 EGR1 TSC2 MTOR RRAGA PDGFRA RRAGC RHEB RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RAC2 TNKS2 TNKS PIK3R3 IRAK1 TRAF6 CD19 G BETA:GAMMA SIGNALLING THROUGH PI3KGAMMA%REACTOME%R-HSA-392451.3 G beta:gamma signalling through PI3Kgamma GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 AKT2 GNG10 AKT1 GNG12 GNG11 GNG13 GNB2 GNB1 PDPK1 GNB4 PIK3R6 PIK3CG GNB3 PIK3R5 GNB5 GNGT1 GNGT2 RHOA AKT3 METABOLISM OF AMINE-DERIVED HORMONES%REACTOME DATABASE ID RELEASE 76%209776 Metabolism of amine-derived hormones ASMT DUOX2 SLC5A5 TPO AANAT TSHB CGA IYD DIO1 DIO2 DIO3 TPH2 TH DDC PNMT TPH1 DUOX1 DBH SIGNALING BY HIGH-KINASE ACTIVITY BRAF MUTANTS%REACTOME DATABASE ID RELEASE 76%6802948 Signaling by high-kinase activity BRAF mutants FN1 BRAF FGB FGA VWF FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CSK HRAS MARK3 NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 KSR2 SRC FGFR1B LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190370.2 FGFR1b ligand binding and activation FGF22 FGF1 FGF2 FGF3 FGF10 PEPTIDE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 76%375276 Peptide ligand-binding receptors CXCL10 PYY CXCL11 CXCL12 RLN2 RLN3 NMUR2 NMUR1 CXCL6 CXCL9 CXCL8 MLNR OXT ECE1 CXCL1 ECE2 TRH CXCL3 CXCL2 CXCL5 HEBP1 GPER1 BDKRB2 PRLHR BDKRB1 INSL3 QRFPR INSL5 NPY5R AVPR2 OPRM1 SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 CORT XCL2 XCL1 CX3CR1 NPY4R OPRL1 CCL7 CCL5 CCL4 CCL3 CCL2 CCL1 OPRK1 CCK HCRTR2 APLN HCRTR1 KISS1 POMC SST ACKR4 ACKR3 ACKR2 ACKR1 NPFFR2 APP OXTR NPFFR1 RXFP4 GRPR RXFP1 RXFP2 RXFP3 EDNRA EDNRB C3AR1 PROK2 PROK1 UTS2R NPFF GPR37L1 PDYN TRHR UTS2B KEL AGTR1 AGTR2 FPR1 FPR3 FPR2 C3 NLN MC2R C5 GALR3 GALR2 GALR1 NPBWR1 PENK NPBWR2 PPY HCRT CCR10 NTSR1 NTSR2 CCR1 NMB XCR1 PPBP NMBR MC1R NMS PNOC NMU QRFP CX3CL1 MLN BRS3 MC4R CCKAR CCR9 CCR8 CCR7 CCR6 CCR5 CCR4 CCR3 CCR2 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B TACR2 TACR3 AVPR1A TACR1 F2 MC3R GAL CCKBR AVP NPSR1 OPRD1 CCL13 NPB CCL11 GRP CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R CCL19 PRLH CCL17 CCL16 CCL25 CCL22 CCL21 CCL20 AGT XK MT-RNR2 MC5R SAA1 F2RL1 CCL28 CCL27 F2RL2 PF4 F2RL3 NPY2R PMCH CXCL13 CXCL16 CCRL2 GHSR F2R NPY1R APLNR UTS2 CCL3L3 C5AR2 C5AR1 NTS MCHR1 MCHR2 KNG1 PSAP TAC3 TAC1 ALPHA-OXIDATION OF PHYTANATE%REACTOME%R-HSA-389599.2 Alpha-oxidation of phytanate PHYH SLC25A17 HACL1 SLC27A2 PECR RESPONSE TO METAL IONS%REACTOME DATABASE ID RELEASE 76%5660526 Response to metal ions MT2A MT1A MT1F CSRP1 MT1G MT1H SNCB MT1B MT1E MTF1 MT4 MT3 MT1M MT1X SCAVENGING BY CLASS F RECEPTORS%REACTOME%R-HSA-3000484.1 Scavenging by Class F Receptors HSP90AA1 HSPH1 porB APOB CALR HYOU1 SCARF1 TP53 REGULATES TRANSCRIPTION OF SEVERAL ADDITIONAL CELL DEATH GENES WHOSE SPECIFIC ROLES IN P53-DEPENDENT APOPTOSIS REMAIN UNCERTAIN%REACTOME%R-HSA-6803205.1 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 TP53BP2 RABGGTB NDRG1 RABGGTA BCL2L14 BIRC5 CHM TP73 PERP PPP1R13B TP53I3 BCL6 TP63 INLA-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELLS%REACTOME%R-HSA-8876493.1 InlA-mediated entry of Listeria monocytogenes into host cells inlA UBB CBLL1 UBA52 UBC CDH1 RPS27A CTNNB1 SRC CTNND1 DECTIN-1 MEDIATED NONCANONICAL NF-KB SIGNALING%REACTOME%R-HSA-5607761.1 Dectin-1 mediated noncanonical NF-kB signaling BTRC SKP1 PSMD8 PSMD9 PSMD6 FBXW11 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 RELB PSMA2 UBA3 PSME3 MAP3K14 PSME4 UBE2M PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 CHUK UBC PSMB8 RELA PSMB9 RPS27A SEM1 NFKB2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FORMATION OF THE ACTIVE COFACTOR, UDP-GLUCURONATE%REACTOME DATABASE ID RELEASE 76%173599 Formation of the active cofactor, UDP-glucuronate UGP2 UGDH SLC35D1 SYNTHESIS OF PIPS AT THE ER MEMBRANE%REACTOME%R-HSA-1483248.6 Synthesis of PIPs at the ER membrane PI4K2B SBF1 MTMR2 SACM1L PI4KA NEGATIVE REGULATION OF ACTIVITY OF TFAP2 (AP-2) FAMILY TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 76%8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors TFAP2C TFAP2E WWOX SUMO1 KCTD1 TFAP2A UBE2I KCTD15 TFAP2B TFAP2D DEFECTIVE SLC24A4 CAUSES HYPOMINERALIZED AMELOGENESIS IMPERFECTA (AI)%REACTOME%R-HSA-5619055.1 Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI) SLC24A4 BDNF ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9024909.1 BDNF activates NTRK2 (TRKB) signaling BDNF NTRK2 SIGNAL TRANSDUCTION BY L1%REACTOME%R-HSA-445144.1 Signal transduction by L1 NRP1 L1CAM ITGB3 ITGB1 CSNK2A1 ITGA2B ITGAV RAC1 VAV2 MAP2K1 CSNK2A2 MAP2K2 ITGA5 PAK1 MAPK1 EGFR CSNK2B ITGA9 NCAM1 MAPK3 FORMATION OF A POOL OF FREE 40S SUBUNITS%REACTOME DATABASE ID RELEASE 76%72689 Formation of a pool of free 40S subunits RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B DEADENYLATION-DEPENDENT MRNA DECAY%REACTOME DATABASE ID RELEASE 76%429914 Deadenylation-dependent mRNA decay TNKS1BP1 CNOT6L EIF4A3 LSM5 LSM4 LSM3 LSM2 LSM7 LSM6 SKIV2L CNOT10 CNOT4 CNOT6 CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 CNOT9 HBS1L TUT7 EIF4A2 TUT4 EDC3 EIF4A1 EDC4 TTC37 PATL1 NT5C3B DDX6 DCPS PAIP1 LSM1 PAN2 PAN3 DCP1B EIF4E EIF4B DIS3 XRN1 PABPC1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 DCP1A EIF4G1 WDR61 RRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6790901.4 rRNA modification in the nucleus and cytosol RCL1 TBL3 MPHOSPH10 NOL11 NOP10 TRMT112 RPS14 DDX49 DDX47 WDR3 NOP56 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RPS9 RRP9 RPS7 FBL BUD23 SNU13 UTP14A UTP14C NOP58 UTP15 WDR36 UTP11 IMP3 RPS6 DIMT1 WDR75 IMP4 DDX52 UTP18 DIEXF DKC1 NHP2 TSR3 HEATR1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 GAR1 RRP36 UTP20 DCAF13 UTP6 NOP2 NOP14 UTP4 RPS2 PNO1 KRR1 UTP3 TRANSPORT OF NUCLEOSIDES AND FREE PURINE AND PYRIMIDINE BASES ACROSS THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 76%83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane SLC25A5 SLC29A1 SLC28A2 SLC25A4 SLC28A1 SLC29A3 SLC25A6 ARL2BP SLC29A2 SLC28A3 ARL2 SLC29A4 G2 M CHECKPOINTS%REACTOME DATABASE ID RELEASE 76%69481 G2 M Checkpoints RHNO1 BLM BRIP1 ATRIP BRCC3 BARD1 RAD17 RAD9B ATR RAD9A BABAM1 BABAM2 YWHAQ BRCA1 UIMC1 YWHAH EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 YWHAE RMI1 TOP3A WRN RBBP8 RPA1 H3-4 RPA2 RAD50 YWHAG RPA3 RAD1 GTSE1 CDC25C CLSPN PKMYT1 HERC2 TP53BP1 CDC7 UBA52 YWHAB RNF168 ABRAXAS1 CCNB2 CCNB1 UBB YWHAZ UBC RPS27A MDC1 UBE2V2 CDK1 PIAS4 CHEK2 TP53 CDK2 ATM SUMO1 WEE1 SFN MCM7 MCM8 H2AX MCM3 MCM4 MCM5 MCM6 MCM2 RNF8 ORC5 NSD2 ORC4 ORC6 H2BC21 ORC1 H2BU1 ORC3 ORC2 CDC6 H2BC17 H2BC12 H2BC13 CHEK1 H2BC14 CDC25A H2BC15 H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 MCM10 PSMD4 DBF4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 H2BS1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CDC45 PSME1 H2BC9 PSME2 PSMD10 H4C9 PSMB11 PSMD12 H2BC8 PSMD11 H2BC5 PSMD14 PSMD13 H2BC3 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MRE11 KAT5 NBN HUS1 UBE2N DNA2 DEFECTIVE SLC27A4 CAUSES ICHTHYOSIS PREMATURITY SYNDROME (IPS)%REACTOME DATABASE ID RELEASE 76%5619108 Defective SLC27A4 causes ichthyosis prematurity syndrome (IPS) SLC27A4 ALPHA-LINOLENIC ACID (ALA) METABOLISM%REACTOME DATABASE ID RELEASE 76%2046106 alpha-linolenic acid (ALA) metabolism ABCD1 ACOT8 ELOVL1 FADS2 SCP2 ACAA1 ELOVL5 ACSL1 ELOVL2 ELOVL3 HSD17B4 FADS1 MET INTERACTS WITH TNS PROTEINS%REACTOME%R-HSA-8875513.1 MET interacts with TNS proteins HGF MET TNS4 TNS3 ITGB1 DCC MEDIATED ATTRACTIVE SIGNALING%REACTOME DATABASE ID RELEASE 76%418885 DCC mediated attractive signaling PTK2 DOCK1 WASL RAC1 TRIO CDC42 ABLIM1 SRC DCC ABLIM2 ABLIM3 NTN1 NCK1 TRANSCRIPTION OF E2F TARGETS UNDER NEGATIVE CONTROL BY P107 (RBL1) AND P130 (RBL2) IN COMPLEX WITH HDAC1%REACTOME DATABASE ID RELEASE 76%1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 HDAC1 TFDP1 TFDP2 RBBP4 E2F1 LIN54 RBL2 RBL1 MYBL2 LIN52 E2F4 LIN37 LIN9 E2F5 CDK1 CCNA2 TRAF6 MEDIATED IRF7 ACTIVATION%REACTOME%R-HSA-933541.5 TRAF6 mediated IRF7 activation CREBBP IFNA21 IRF7 IFNB1 SIKE1 TRAF2 IFNA5 IFNA4 IFNA7 IFNA6 TANK IFIH1 IFNA2 RNF135 MAVS DDX58 IFNA8 EP300 TRIM25 IFNA13 IFNA14 TBK1 IFNA16 IFNA17 IKBKE IFNA10 IRF3 TRAF6 ORC1 REMOVAL FROM CHROMATIN%REACTOME%R-HSA-68949.3 Orc1 removal from chromatin CCNA1 CDK2 RBX1 MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 DISEASE%REACTOME DATABASE ID RELEASE 76%1643685 Disease CREBBP SHH HHAT DHH IHH F8 GSK3A ENO1 DUSP16 CORO1A eis lpdC esxH esxG RNF213 esxA Rv1410c PGK1 ATP6V1H MAPK1 TRIM27 sapM Rv3655c ndkA MAPK3 KPNA1 Rv3364c ptpA secA2 NOS2 VPS33B PPE2 lprG lprM SFPQ HGS RAB5A KPNB1 Rv3654c RAB7A CYP27B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL SEMA5A RPL36 RPL35 ITGA2B RPLP2 RPL38 MAP2K1 RPL37 RPS11 MAP2K2 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 NCBP1 RPS8 NCBP2 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 ITGB3 RPL29 PIK3CD RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 MET RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 DAG1 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU TLN1 RPS21 RPL26L1 RPS24 RPS23 H2AX H2AB1 H2AC19 CHD4 CHD3 ACTB H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 H2BC11 HDAC2 HDAC1 H3C15 MTA1 RBBP4 H2BS1 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 GATAD2B GATAD2A H2AC20 SFTPC IKBKB CHUK CASP9 IKBKG SLC22A5 NMT1 SLC22A18 HDAC3 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 STAT3 SI LCT MAOA COMT RANGAP1 CSK KDR DAXX ATRX ALG2 SLC26A2 B4GALT1 SDC4 SDC2 HEXB SDC3 HEXA PRELP PAPSS2 GPC1 GPC3 GPC2 GPC5 GPC4 CHST14 GPC6 ST3GAL3 TRAK1 CHST6 B3GAT3 LUM OMD KERA B3GALT6 EXT1 EXT2 OGN SDC1 FMOD AGRN B4GALT7 SKP2 FZR1 NUS1 DHDDS fliC TLR10 IRAK4 TLR5 MYD88 LY96 FASLG TICAM1 CD14 TLR4 MMAA MMUT AKT2 MLST8 GYS1 GYG1 TSC2 MTOR AKT1S1 ITGB1 VCL CYFIP1 NCKAP1 BRK1 PDGFB PDGFRB STAT1 botF SV2C SV2B SV2A VAMP1 CYBA CD86 CD80 VAV2 BCR NOXO1 PIK3R2 HDAC6 8b ZCRB1 DDX5 9b UVRAG NCKAP1L WASF1 WASF2 JAG1 BAIAP2 ABI2 ABI1 NOXA1 NOX1 CDKN1C RB1 CCND3 TFDP1 CDK6 CCND2 HNRNPK TFDP2 CCND1 CDK4 E2F1 E2F2 E2F3 MAML2 MAML1 RBPJ MYC ITGA4 MAML3 NOTCH1 SRC FOXO3 BCL2L11 HES1 TCF7L2 SMAD4 SMAD3 SNW1 CTNNB1 KRAS MAMLD1 GTF2A1 GTF2A2 GTF2B TAF9 TAF1L GTF2E1 GTF2E2 TAF7L TAF9B TAF15 TAF12 TAF13 TAF10 TAF11 TAF7 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TBK1 ISG15 TRAF3 FIP1L1 C1QBP FGB FGA F10 VWF GP1BB F12 F11 FGG GP1BA GP5 GP9 SGSH IDS F9 GUSB IDUA SERPING1 E MCCC2 PC PCCA HLCS MCCC1 PCCB MAP2K4 ACACA MAP2K7 TBL1XR1 FOXO6 NR4A1 RPS6KB2 TBL1X FDXR EEF2 CYP1B1 CYP2U1 FDX1 FDX2 PPP2R1B PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C FGR ITPR1 ITPR2 ITPR3 ACY1 PPP2CA PPP2CB CYP21A2 PTPN11 P2RX7 P2RX4 GSS CALM1 MAPK8 DYNLL2 MTRR TPMT CYP4F22 CYP19A1 CYP11A1 GCLC SLC5A5 CYP11B2 TBXAS1 GCLM OPLAH UGT1A1 PAH UGT1A4 AHCY PAPSS1 MAT1A MTR FGFR2 HDAC10 HDAC11 ARAF CCNC MPRIP FGFR1OP2 TRIM24 DKK1 SND1 DKK2 DKK4 BIN2 ZC3HAV1 FXR1 CD19 ATG7 SLC3A2 BRAP JAG2 FN1 FZD8 BRAF NOX4 GRB2 STRN ZMYM2 HEY1 HEY2 KREMEN1 AGTRAP KREMEN2 DUSP8 TXNRD1 DUSP9 CNKSR2 APBB1IP CNKSR1 MRAS AMER1 KANK1 NEURL1B LMNA SHOC2 AGK SYVN1 MIB2 SLC24A1 MIB1 SLC24A4 HEYL AGGF1 PEBP1 KDM1A PIM1 RNF43 HGF FAM114A2 PORCN MARK3 CPSF6 WNT3A ESR2 QKI CDK8 FGFR3 FGFR1 TENT4A KIAA1549 DUSP10 MYO18A KSR1 KSR2 ETV6 ESRP1 KDM7A HDAC5 LRP5 HDAC8 HDAC9 DLL1 HDAC7 LRP6 PHF21A DLL4 HES5 TRAT1 FAM131B NEURL1 PIK3AP1 ABL1 CDK5 RCOR1 CALR SIN3A HMG20B RAC1 JAK2 DOCK2 DOCK1 ALDOB SLC6A20 PA PB2 NP NA NS HA M PB1 CLTA AP2A1 AP2A2 G6PC1 AP2M1 CUBN AMN APOA1 AP2S1 ABCA1 AP2B1 DNAJC3 TCEA1 SMAD2 GUCY2C PDZD3 sta1 POMT2 POMT1 ST6GALNAC2 RPN2 PRKCSH TUSC3 RPN1 MAGT1 FUT8 GANAB S MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 SLC35D1 SLCO1B1 SLCO1B3 SLC35A2 SLC35A1 SLC35A3 SLC35C1 SLC33A1 SLCO2A1 SLC25A5 SLC25A4 SLC29A3 SLC25A6 SLC27A4 MUC13 FMO3 AKT3 AP1S2 AP1S1 AP1S3 VPS36 DYNC1LI1 DYNC1LI2 VPS25 VPS28 GNS FZD4 SNF8 ARF1 ARPC1A AREG VAMP2 HBEGF EGFR TRIM28 UBAP1 DVL2 AP1M2 AP1M1 ARPC4 ARPC5 ARPC2 ARPC3 ARRB1 ARRB2 AP1G1 ACTR2 VPS37C VPS37D VPS37A VPS37B VPS4B VPS4A MYO1C GOLGA2 GOLGA4 AP1B1 EREG BTC CFTR TGFA MYO5A STAM SH3KBP1 CD3G MAP1LC3B SEC13 AP3B1 CUX1 EPS15 DYNC1I1 EPGN TRIP11 SH3GL3 SH3GL2 SH3GL1 WNT5A CHMP4C CHMP4B CHMP4A STAM2 TSG101 SYT2 SYT1 VTA1 CHMP2B CHMP2A THBS1 MYH9 CHMP3 CHMP6 CHMP7 CHMP5 CBL MVB12B MVB12A EGF GALNT1 XRCC4 SLC9A6 SLC9A9 ZBP1 DUSP6 DUSP7 CAMK2B CAMK2D CAMK2A GPS2 CAMK2G NCOR2 CREB1 NCOR1 CAMK4 S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 HMGA1 ABCB11 SFTPA2 RCC1 CYP7B1 CYP27A1 PDGFRA NFKBIA RELA NFKB2 SLC34A1 gag TNKS2 TNKS SLC17A5 SLC17A8 FZD5 FZD6 FYN GGCX CFP SNAP25 PGM1 CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP ARSB NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 GAA TTR LRAT RBP4 RBP1 CDC25A NUP107 NUP188 SLC4A1 ABCA12 SLC4A4 SLC12A6 SLC39A4 SLC34A3 ABCG8 SLC34A2 ABCG5 SLC6A19 SLC6A18 NUP210 SLC6A14 SLC11A2 NUP93 PPIA SLC5A7 VCP POM121 NUP205 ABCB6 ABCB4 SEL1L SLC1A1 SLC1A3 SLC5A1 AAAS SLC5A2 NUP160 POM121C NUP85 TPR NUP88 GCKR NUP155 ABCA3 ERLIN1 NUP153 HGSNAT ERLIN2 CP SLC2A9 SLC6A5 SLC26A4 SLC26A3 RNF185 ABCD4 SLC2A1 SLC40A1 SLC2A2 SLC6A2 GALNS SLC6A3 HK1 SLC22A12 HEPH NUP62 ABCD1 NDC1 ABCC2 SLC36A2 NUP133 ABCC8 SLC2A10 ABCC6 ABCC9 SLC7A7 HYAL1 SLC7A9 NUP50 NUP54 SLC20A2 DERL3 DERL1 DERL2 SLC3A1 RNF5 ERLEC1 OS9 NUP42 rev NUP43 RAE1 gag-pol vif RANBP2 NMT2 SLC12A3 SLC16A1 vpr vpu KCNJ11 NAPEPLD SLC12A1 GCK NUP35 RHAG NUP37 VAV3 RHOG VAV1 ELMO2 CSF2RB CSF2RA MAP3K11 OGG1 NTHL1 NEIL3 NEIL1 NFKB1 TLR3 HSP90AB1 PTGES3 FKBP4 TYK2 NOTCH2 LFNG NOTCH3 NOTCH4 ARPC1B ACTG1 LYN YES1 PTK2 PPP1CC ACE2 TMPRSS2 7a 3a SHC1 GAB1 PIK3CA PLCG1 SOS1 CTBP2 CTBP1 MPI DPM1 DPM2 DPM3 GNE NEU1 CTSA GFPT1 PMM2 SRD5A3 DOLK GLB1 NRG1 NRG2 NRG3 NRG4 ELMO1 CRK FOXO1 STAT5A STAT5B PABPN1 KPNA7 KPNA4 KPNA5 KPNA2 KPNA3 CPSF4 EIF2AK2 KIT ELK1 TPST2 TPST1 STX1B STX1A CYP11B1 CDC25C CDC25B PML DBP UNC93B1 UL36 PSEN2 APH1A BAG4 APH1B PSENEN BAD PHB CEBPD FEN1 MAPKAP1 tetX cya lef pagA BARD1 PRR5 BRCA1 PDPK1 RICTOR CDK5R1 ADCYAP1 ADCYAP1R1 VHL ARID4B SAP30 DNMT1 SUDS3 EZH2 RDH5 DNMT3B EED SAP30L SAP18 SUZ12 JUN SOD2 LMNB1 PRDX2 PRDX1 CCNK TXN PLK2 PMS2 NPM1 MLH1 CCNT2 MSH2 CTNND1 inlA CBLL1 PTEN CASP1 CYFIP2 VIPR1 VIPR2 AHCYL1 SCT WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 GPR176 IGKV1-16 GNAT3 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 ENTPD1 IGHV3-30 V2-17 IGHV3-33 ENTPD5 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 TXNIP V1-11 IGKV2D-30 GIPR V1-16 V1-13 IGHV1-69 MEFV CRHR1 CRHR2 GHRHR PLCG2 HMOX1 GSDMD V1-20 GPR15 IGKV2D-40 IGHV3-11 FZD7 IGHV3-13 GPR27 GPR25 GPR20 IGHV1-46 ADM PTH1R IGHV IL10 SCP LPG1G2 CVC2 V5-4 CVC1 V5-1 B3GLCT SYK ADAMTS12 GPR32 ADAMTS10 IL18 ADAMTS15 PTH2R ADAMTS14 V5-6 ADAMTS13 HCK RDH12 IL1A ADAMTS19 IL1B ADAMTS17 IGLV3-19 NEC1 RAMP2 NEC2 RAMP3 B4GAT1 GPR45 SFTA3 PTH US12 GNAI3 US11 WAS US10 PRKX MSH3 GNAI1 US28 GNAI2 HSP90AA1 US27 CDC37 IGLV3-25 US26 NT5E ERBB2 US24 IGLV3-27 ERBIN US34 IGKC US32 YWHAE IGLV3-21 US30 GPR150 V4-6 US19 V4-2 US18 V4-1 US17 PPP1CB US16 IGKV1-5 SCTR US14 US13 MYO9B G6PC3 GCG PPP2R1A US23 GHRH US22 ADM2 US20 RAMP1 RLBP1 IGLV BTRC PRKACA MUC5AC IGHG3 ADAMTS20 PYCARD THSD7B IGHG4 C1GALT1C1 IGHG1 THSD7A IGHG2 ALG8 GGT1 ALG9 V3-4 SKP1 ALG6 V3-3 ALG3 V3-2 ALG1 IGKV1D-39 BTD IGKV1D-33 UL147A DPEP2 KHK TUBB DPEP1 MUC12 IAPP MUC15 DPEP3 SFTPB GNAZ SFTPD CALCA CYP17A1 CALCB UL103 CALCRL MUC3A IGHV4-59 UL102 GPR83 MUC3B DYNLL1 GPR84 UL104 IGLV2-11 NCKIPSD MUC16 MUC17 CALCR MUC19 IGLV1-40 MUC20 IGLV1-47 AKAP9 MUC21 IGLV6-57 GALK1 IGLV2-14 HA-33 DVL1 GALT IGLV1-44 UBA52 MUC5B IGKV3-15 GALE DVL3 TCN2 NLRP3 ADAMTSL1 IGKV3-11 DYNC1I2 ADAMTSL5 V2-8 ADAMTSL4 GGT5 ADAMTSL3 CD163 ADAMTSL2 IGLV7-43 inlB IGKV1D-16 CUL1 IPO5 IGKV1D-12 LARGE1 IL6 IGLV1-51 ADAMTS2 ADAMTS3 IGLV2-23 ADAMTS6 UBB IGKV3-20 ADAMTS7 GLP1R IGHV4-34 THSD1 PRKAR2B THSD4 IGHV1-2 IGHV4-39 CD320 UBC GBE1 FCGR3A PSTPIP1 CHMP1A UL119/UL118 RPS27A IGKV2-29 UL11 IGKV2-28 UL18 IGLC3 UL17 IGLC1 UL16 IGLC2 V1-9 UL14 DYNC1H1 V1-7 UL13 V1-5 UL32 V1-3 UL31 HELI RHBDF2 UL38 GLP2R UL37 IGKV3D-20 GIP UL35 UL34 MYH2 CRH ALG14 ALG13 IGKV2-30 LIG4 IGHV2-70 ALG12 IGHV2-5 IGHV3-48 CEP43 ALG11 IGLV3-1 UL29 PTH2 HDAC4 UL27 UL26 PTHLH UBE2I IGKV1-39 UL25 IGKV1-33 UL24 UL23 FCGR1A UL54 WASF3 IGHV3-53 UL52 NR3C1 CBX1 IGLC7 MYO10 UL44 IGKV5-2 UL43 ESR1 UL48 IGLC6 UL47 FCGR2A SUGT1 UL76 UL74 VIP UL71 FLT3 UL70 nef UL79 SUMO1 B2M HLA-A UL78 POMGNT1 CD8B LCK RFT1 UL131A PACS1 UL41A CD28 UL69 UL112/UL113 CCNH RNMT UL91 POLR2A THBS2 POLR2B UL99 POLR2C UL98 POLR2D MUC1 POLR2E UL97 POLR2F MUC2 POLR2G UL96 POLR2H UL95 POLR2I UL94 POLR2J UL92 POLR2K MUC7 POLR2L MUC4 RNGTT MUC6 UL80 GTF2H1 UL88 GTF2H2 UL87 SUPT5H UL84 GTF2F1 UL83 GTF2H3 UL82 GTF2H4 ntnha GTF2F2 UL2 GTF2H5 UL4 CDK7 ERCC3 UL5 ERCC2 UL7 MNAT1 UL9 ANAPC15 UL22A ANAPC16 ha17 EPM2A ANAPC7 UBE2C US3 UBE2E1 US2 UBE2D1 US9 ANAPC10 US8 ANAPC11 MCP CDC23 ha70 TALDO1 UBE2S DUT CDC26 MMAB CDC16 RL11 CDC27 RL10 RPIA ANAPC4 SPON2 ANAPC5 SPON1 ANAPC1 PPP1R3C PSMD8 MMADHC PSMD9 US33A PSMD6 US34A PSMD7 SBSPON NAGLU PSMD4 RL9A RL8A PSMD5 DPAGT1 PSMD2 BANF1 PSMD3 botG PSMD1 SSPOP PSMA5 botE PSMA6 botD botA PSMA3 botB PSMA4 PSIP1 PSMA1 LMBRD1 PSMA2 GALNT3 PSME3 NHLRC1 PSME4 UL15A PSME1 UL130 PSME2 UL132 PSMD10 UL133 PSMB11 UL138 CD9 PSMD12 TRM3 PSMD11 TRM2 PSMD14 TRM1 PSMD13 UL144 UL147 PSMA7 UL146 PSMB10 1a UL148 rep PSMA8 gB PSMB6 gH PSMB7 gL PSMB4 gM PSMB5 gN PSMB2 UL114 PSMB3 UL121 APC PSMB1 UL120 PSMF1 UL123 PAK2 UL122 PSMB8 UL124 PSMB9 UL117 SEM1 SEMA5B PSMC5 TRS1 PTPN12 PSMC6 GYG2 PSMC3 RL1 PSMC4 CUL5 PSMC1 MPDU1 RAP1B PSMC2 STRA6 RAP1A SLC37A4 RAF1 TRX1 SFTPA1 MMACHC TRX2 MUCL1 UL111A CBLIF GYS2 RANBP1 C1GALT1 GALNT12 UL21A GRSF1 DCXR CASP8 RAN TRADD RIPK1 TRAF2 FADD APP HTR4 NEDD4L RXFP1 RXFP2 HTR6 HTR7 C3AR1 PTGDR ABCA4 TAAR8 TAAR9 TAAR6 FXYD4 TAAR5 TAAR2 FXYD3 FXYD2 FXYD1 TAAR1 FXYD7 FXYD6 LHB C3 MC2R CGA MC1R MC4R OPN1LW CCR5 GPR39 AVPR1B FSHB GPBAR1 AVPR1A F2 MC3R ADRB3 OPN1MW FSHR AVP PTGER4 NPSR1 PTGER2 CXCR4 NPS GPHA2 P2RY11 MC5R GPHB5 CYSLTR1 CYSLTR2 LHCGR ADRB1 ADRB2 TAAR3P HRH2 DRD1 DRD5 RLN2 RLN3 ATP1B3 ATP1B2 ATP1B1 INSL3 TSHB PTGIR AVPR2 ADORA2A ADORA2B ATP1A4 ATP1A3 ATP1A2 ATP1A1 S1PR1 TSHR POMC OPN1SW CLCN6 MSH6 CAPNS1 CAPNS2 CDH1 BSG LIG1 PARP1 CAPN2 CAPN1 CAST ADAM10 HSPG2 BCAN ADAM17 PSEN1 ADAMTS16 NCSTN ADAMTS18 PRIM2 PRIM1 POLA1 POLA2 GSDME ADAMTS4 ADAMTS5 ADAMTS1 CTSL CTSG ADAMTS8 ADAMTS9 DCN FURIN IFNGR1 IFNGR2 JAK1 ACAN BCL2L1 LRRFIP1 KLKB1 XRCC6 XRCC5 KLB IRS1 PIK3R4 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 TLR1 FGF9 FGF20 FGF23 FGF22 S100A9 FLT3LG S100A8 FRS2 TLR2 GAB2 LTF FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 H2AC17 H2AC12 H2AC21 H2AW WDR48 env CD4 CLTC WASL PIK3R1 IQGAP1 CDC42 H2AC1 SPTBN1 FOXO4 NCK1 PARP10 PARP6 GSK3B PARP4 PARP16 PARP9 AXIN1 PARP14 N H2BC18 BECN1 PARP8 YWHAB XPO1 AKT1 NUP214 MAPK14 HSPA1A CDKN1A CDKN1B IDH1 CCNE2 CCNE1 CDKN2A CDK2 MDM2 PRKACG PRKACB RBX1 ADCY9 PRKAR1B PRKAR1A PRKAR2A PDCD6IP RIR1 GNAS ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 ARID4A NS5B JAK3 IL6R IL1R1 SIGMAR1 BRMS1 TLR7 NCAN IFNAR1 BGN BRD4 CRBN VCAN CHSY1 STAT2 REST IMPDH1 IMPDH2 PDCD1 CSPG5 CSPG4 CHST3 rpoA rpoC rpoZ Rv1281c ROCK1 msrA ROCK2 irtB irtA Rv2779c sodC sodB ahpE ahpD MRC1 ahpC katG secY secF secE Rv1280c secA1 secG secD Rv2895c SPRED3 MT2748 SPRED2 SPRED1 bfr pstS1 HRAS dlaT mscR Rv1283c trx-2 Rv1282c glbN fgd1 ggt-1 NRAS trxA bfrB cpnT NF1 tpx trxB RAC2 TGFB1 PIK3R3 TGFBR1 TGFBR2 FKBP1A MINERALOCORTICOID BIOSYNTHESIS%REACTOME%R-HSA-193993.2 Mineralocorticoid biosynthesis CYP11B2 CYP21A2 LHB CGA HSD3B2 HSD3B1 REGULATION OF GENE EXPRESSION IN BETA CELLS%REACTOME DATABASE ID RELEASE 76%210745 Regulation of gene expression in beta cells FOXA3 IAPP FOXA2 SLC2A2 GCK HNF4G FOXO1 NEUROD1 NKX6-1 NKX2-2 PDX1 AKT2 PAX6 HNF1A MAFA AKT1 INS RFX6 AKT3 THE FATTY ACID CYCLING MODEL%REACTOME%R-HSA-167826.3 The fatty acid cycling model SLC25A27 UCP3 UCP2 UCP1 SLC25A14 ACTIVATION OF CASPASES THROUGH APOPTOSOME-MEDIATED CLEAVAGE%REACTOME%R-HSA-111459.3 Activation of caspases through apoptosome-mediated cleavage XIAP CASP9 APAF1 CASP7 CASP3 CYCS NUCLEAR ENVELOPE BREAKDOWN%REACTOME DATABASE ID RELEASE 76%2980766 Nuclear Envelope Breakdown LPIN2 LPIN3 PRKCB BANF1 NEK9 NUP42 NUP210 NEK6 NUP43 NEK7 RAE1 VRK1 RANBP2 LEMD2 NUP93 CTDNEP1 CNEP1R1 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 CCNB2 CCNB1 NUP214 NUP153 PRKCA LMNB1 EMD SEC13 NUP62 LEMD3 NDC1 PLK1 NUP133 CDK1 NUP107 NUP188 NUP50 NUP54 LPIN1 APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS%REACTOME%R-HSA-351906.1 Apoptotic cleavage of cell adhesion proteins DSP PKP1 DSG2 CDH1 DSG3 OCLN CASP3 TJP1 CTNNB1 TJP2 DSG1 NEF MEDIATED CD4 DOWN-REGULATION%REACTOME%R-HSA-167590.1 Nef Mediated CD4 Down-regulation CD4 AP2A1 AP2B1 AP2A2 AP2S1 ATP6V1H AP2M1 nef ARF1 LCK PROTEIN UBIQUITINATION%REACTOME DATABASE ID RELEASE 76%8852135 Protein ubiquitination DERL1 RTF1 LEO1 UBE2B RAD18 PAF1 UBE2Z UBE2L3 UBE2Q2 HLA-A RNF152 SHPRH UBE2E3 PCNA RNF40 RNF144A CDC34 UBE2R2 SELENOS WAC UBA6 BCL10 UBE2J2 HLTF TMEM129 UBE2H UBE2G1 UCHL3 UBE2A UBE2G2 US11 UBE2W UBE2T RNF181 UBA1 UBE2D2 UBE2D3 H2BC17 H2BC12 UBE2C UBE2E1 H2BC13 UBE2D1 H2BC14 PEX2 H2BC15 UBE2S USP5 UBE2K H2BC11 USP9X VCP RNF20 PRKDC PEX10 H2BC9 PEX12 UBA52 PEX13 H2BC8 PEX14 H2BC5 H2BC3 H2BC1 HLA-B OTULIN UBB RRAGA UBC RPS27A USP7 UBE2V2 CDC73 CTR9 UBE2N WDR61 NGF-STIMULATED TRANSCRIPTION%REACTOME%R-HSA-9031628.2 NGF-stimulated transcription REST NAB1 NAB2 ID1 EGR2 FOS MEF2D F3 CDK5 ELK1 SH3GL3 ATF1 TPH1 EGR1 SRF DNM2 CHD4 TCF12 RRAD ASCL1 LYL1 EP300 JUND VGF EGR3 EGR4 FOSL1 ARC SGK1 ID2 ID4 FOSB CREB1 ID3 TRIB1 CDK5R2 JUNB ATF2 CDK5R1 RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER%REACTOME DATABASE ID RELEASE 76%76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter CRCP POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 BRF1 BDP1 POLR1C POLR1D DISEASES ASSOCIATED WITH THE TLR SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 76%5602358 Diseases associated with the TLR signaling cascade IRAK4 TLR5 MYD88 LY96 FGB FGA TICAM1 CD14 TLR4 FGG S100A1 HMGB1 TIRAP mip UNC93B1 BTK porB TLR6 CD36 IKBKB CHUK NFKBIA RELA IKBKG NFKB2 TLR1 S100A9 S100A8 TLR2 TRAF3 NFKB1 TLR3 fliC TLR10 PHOSPHORYLATION OF PROTEINS INVOLVED IN G1 S TRANSITION BY ACTIVE CYCLIN E:CDK2 COMPLEXES%REACTOME%R-HSA-69200.2 Phosphorylation of proteins involved in G1 S transition by active Cyclin E:Cdk2 complexes CCNE2 RB1 CCNE1 CDK2 BETA OXIDATION OF PALMITOYL-COA TO MYRISTOYL-COA%REACTOME DATABASE ID RELEASE 76%77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA HADHB HADHA ACADVL SMAC (DIABLO) BINDS TO IAPS%REACTOME DATABASE ID RELEASE 76%111463 SMAC (DIABLO) binds to IAPs XIAP CASP9 APAF1 CASP7 CASP3 DIABLO CYCS FATTY ACID METABOLISM%REACTOME DATABASE ID RELEASE 76%8978868 Fatty acid metabolism ELOVL1 FADS2 SCP2 ELOVL5 NUDT19 ACSL1 ELOVL2 PHYH ELOVL3 FADS1 PLA2G4A GPX2 ACOT2 GPX1 GPX4 ALOX15 ALOX12 ALOX12B ALOXE3 CYP4F2 CYP4F3 CYP4F8 HACL1 HAO2 CYP1A1 EPHX2 CPT2 MID1IP1 THRSP PRKAB2 SLC25A20 CPT1B PRKAA2 PPARD PRKAG2 CROT PTGS1 CYP2C9 CYP2C8 CYP1A2 GGT1 ACADVL FAAH SLC25A17 ACAA2 ABCC1 ACSM3 ECI1 ACSM6 ACOX3 ACAD11 DPEP2 HADH DPEP1 ACAD10 PTGES3 ACOT9 DPEP3 MECR ACOT7 ACOT11 ACSL6 HPGDS ACOT12 ACSL5 ACOT13 ACSL3 ACOT1 SLC27A3 PTGES HACD1 HPGD HACD3 LTA4H HACD2 HACD4 THEM5 CYP4F22 HTD2 CYP2C19 MORC2 DECR1 ACBD7 NUDT7 ACBD6 ACLY GGT5 ACBD4 CRAT TECRL ACSF3 CYP2J2 MCAT ALOX15B ACSF2 PRXL2B CYP4F11 PPT1 PPT2 HADHB ACOT7L HADHA SLC25A1 ACADL TECR MAPKAPK2 PCTP DBI TBXAS1 ACOXL MCEE ACADM CYP4A22 ACADS CBR1 ELOVL4 FAAH2 ELOVL7 PTGR1 PTGR2 ACSBG1 ACSBG2 PON3 CYP4A11 PON2 PON1 HSD17B3 HSD17B12 LTC4S HSD17B8 AWAT1 CBR4 OLAH ALOX5AP ELOVL6 RXRA SCD CYP4B1 ECHS1 HSD17B4 ALOX5 PTGS2 ACOT8 EHHADH DECR2 ACOT6 ACAA1 ACBD5 PTGIS ACOT4 AKR1C3 NDUFAB1 CYP8B1 PTGES2 AMACR FASN ACOX2 SLC27A2 MMAA MMUT PCCA PCCB ACACA CPT1A SLC22A5 PTGDS THEM4 ABCD1 CYP1B1 SCD5 CYP2U1 PECR ASTROCYTIC GLUTAMATE-GLUTAMINE UPTAKE AND METABOLISM%REACTOME DATABASE ID RELEASE 76%210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism SLC1A2 SLC1A3 SLC38A1 GLUL RNA POLYMERASE I TRANSCRIPTION%REACTOME%R-HSA-73864.3 RNA Polymerase I Transcription CAVIN1 CCNH POLR2E POLR2F POLR2H MAPK3 H2AX EHMT2 H2AB1 POLR2K H2AC19 POLR2L CHD4 CHD3 GTF2H1 TTF1 GTF2H2 H2AC14 H2BC21 GTF2H3 GTF2H4 H2BU1 H3-3B GTF2H5 H3C8 CDK7 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 TAF1D H3C15 MTA1 TAF1B RBBP4 TAF1C TAF1A H2BS1 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 GATAD2B GATAD2A H2AC20 ERCC6 MBD2 RRN3 UBTF CONSTITUTIVE SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME%R-HSA-2660826.1 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG1 JAG2 ADAM10 ADAM17 DLL1 NOTCH1 DLL4 MPS IV - MORQUIO SYNDROME A%REACTOME%R-HSA-2206290.1 MPS IV - Morquio syndrome A GALNS TRANSLESION SYNTHESIS BY REV1%REACTOME%R-HSA-110312.1 Translesion synthesis by REV1 REV3L RFC5 UBB RFC3 UBC RFC4 RFC2 RPS27A RFC1 PCNA RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 DISEASES OF GLYCOSYLATION%REACTOME%R-HSA-3781865.1 Diseases of glycosylation POMT2 POMT1 B3GLCT ADAMTS12 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS13 THBS1 ADAMTS19 ADAMTS17 B4GAT1 MGAT2 CFP MOGS MAN1B1 MUC5AC ADAMTS20 THSD7B C1GALT1C1 THSD7A ALG8 ALG9 ALG6 ALG3 ALG1 MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 MUC19 SEMA5A MUC20 MUC21 GALK1 GALT MUC5B GALE NOTCH2 ADAMTSL1 LFNG NOTCH3 ADAMTSL5 NOTCH4 ADAMTSL4 ADAMTSL3 ADAMTSL2 LARGE1 MUC13 ADAMTS2 ADAMTS3 ADAMTS6 ADAMTS7 THSD1 THSD4 PGM1 ALG2 SLC26A2 HSPG2 B4GALT1 ALG14 BCAN SDC4 ALG13 SDC2 HEXB ALG12 SDC3 ALG11 HEXA PRELP NOTCH1 PAPSS2 GPC1 GPC3 GPC2 GPC5 GPC4 CHST14 ADAMTS16 GPC6 DAG1 ST3GAL3 CHST6 B3GAT3 ADAMTS18 LUM OMD KERA B3GALT6 EXT1 EXT2 OGN SDC1 POMGNT1 RFT1 FMOD MPI AGRN B4GALT7 ADAMTS4 ADAMTS5 THBS2 ADAMTS1 MUC1 MUC2 DPM1 DPM2 DPM3 ADAMTS8 MUC7 MUC4 ADAMTS9 MUC6 GNE DCN NEU1 CTSA GFPT1 PMM2 SRD5A3 SPON2 DOLK NCAN SPON1 NUS1 DHDDS BGN ACAN VCAN GLB1 CHSY1 SBSPON CSPG5 DPAGT1 CSPG4 SSPOP CHST3 GALNT3 SEMA5B MPDU1 MUCL1 C1GALT1 GALNT12 SYNAPTIC ADHESION-LIKE MOLECULES%REACTOME%R-HSA-8849932.4 Synaptic adhesion-like molecules GRIA3 RTN3 GRIA4 PTPRS GRIN2C PTPRF LRFN3 PTPRD LRFN2 LRFN4 LRFN1 GRIA1 GRIN2B GRIN1 GRIN2D DLG1 DLG3 FLOT1 DLG4 FLOT2 GRIN2A METABOLISM OF INGESTED SEMET, SEC, MESEC INTO H2SE%REACTOME%R-HSA-2408508.2 Metabolism of ingested SeMet, Sec, MeSec into H2Se NNMT HNMT CTH AHCY CBS SCLY GNMT MAT1A RECYCLING OF BILE ACIDS AND SALTS%REACTOME DATABASE ID RELEASE 76%159418 Recycling of bile acids and salts ABCC3 NCOA1 NCOA2 ALB STARD5 SLC10A1 SLC10A2 RXRA SLCO1A2 NR1H4 BAAT FABP6 SLCO1B1 SLC27A5 ABCB11 SLCO1B3 MRNA DECAY BY 5' TO 3' EXORIBONUCLEASE%REACTOME%R-HSA-430039.1 mRNA decay by 5' to 3' exoribonuclease LSM5 LSM4 LSM3 LSM2 XRN1 LSM7 EDC3 LSM6 DCP2 EDC4 PATL1 DDX6 LSM1 DCP1B DCP1A PHENYLKETONURIA%REACTOME DATABASE ID RELEASE 76%2160456 Phenylketonuria PAH TAMATINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9703009.1 tamatinib-resistant FLT3 mutants FLT3 NICOTINAMIDE SALVAGING%REACTOME%R-HSA-197264.5 Nicotinamide salvaging NNMT PTGS2 NAMPT PTGIS NAXE RNLS SLC22A13 NAXD NUDT12 PARP10 PARP6 PARP4 PARP16 PARP9 CYP8B1 PARP14 SLC5A8 PARP8 NAPRT FORMATION OF ANNULAR GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 76%196025 Formation of annular gap junctions CLTC DNM2 CLTB DAB2 GJA1 CLTCL1 AP2M1 CLTA DNM1 ACTIVATION OF AMPK DOWNSTREAM OF NMDARS%REACTOME%R-HSA-9619483.2 Activation of AMPK downstream of NMDARs PRKAA1 CAMKK2 PRKAB2 PRKAA2 PRKAG1 CALM1 PRKAG2 PRKAB1 PRKAG3 DNA STRAND ELONGATION%REACTOME%R-HSA-69190.2 DNA strand elongation POLD2 PRIM2 PRIM1 POLA1 POLA2 GINS1 GINS2 PCNA CDC45 GINS3 GINS4 MCM7 MCM8 MCM3 MCM4 MCM5 RFC5 MCM6 MCM2 RFC3 RFC4 RFC2 LIG1 RFC1 RPA1 RPA2 RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME DATABASE ID RELEASE 76%5658471 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 XBP1(S) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381038.3 XBP1(S) activates chaperone genes KDELR3 ATP6V0D1 SHC1 GSK3A PDIA6 PPP2R5B CUL7 ADD1 FKBP14 SULT1A3 SEC31A CXXC1 TLN1 MYDGF EXTL2 EXTL1 TATDN2 WFS1 DNAJB9 SSR1 EDEM1 EXTL3 LMNA TSPYL2 KLHDC3 ZBTB17 DDX11 SYVN1 WIPI1 PDIA5 YIF1A CTDSP2 DNAJB11 SRPRA SRPRB HDGF TPP1 DNAJC3 PLA2G4B SERP1 HYOU1 ARFGAP1 GFPT1 DCTN1 GOSR2 ACADVL PREB SIGNALING BY BRAF AND RAF FUSIONS%REACTOME DATABASE ID RELEASE 76%6802952 Signaling by BRAF and RAF fusions ATG7 BCL2L11 FN1 TRAK1 BRAF AGTRAP TLN1 VCL CNKSR2 APBB1IP CNKSR1 MAPK1 LMNA AGK MAPK3 PAPSS1 AGGF1 PEBP1 ARRB1 ARRB2 FAM114A2 MARK3 QKI TENT4A KIAA1549 AP3B1 KSR1 KSR2 IQGAP1 ESRP1 KDM7A CALM1 FAM131B FGB FGA VWF FGG AKAP9 ITGA2B MAP2K1 MAP2K2 YWHAB CLCN6 CAMK2B CSK HRAS CAMK2D CAMK2A CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 ARAF JAK2 MPRIP TRIM24 SND1 SRC ZC3HAV1 FXR1 ACTIVATED POINT MUTANTS OF FGFR2%REACTOME DATABASE ID RELEASE 76%2033519 Activated point mutants of FGFR2 FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 LOSS OF FUNCTION OF TGFBR2 IN CANCER%REACTOME DATABASE ID RELEASE 76%3642278 Loss of Function of TGFBR2 in Cancer TGFB1 TGFBR1 TGFBR2 MTB IRON ASSIMILATION BY CHELATION%REACTOME%R-HSA-1222449.2 Mtb iron assimilation by chelation irtA Rv2895c bfr LTF bfrB irtB ESTROGEN-DEPENDENT NUCLEAR EVENTS DOWNSTREAM OF ESR-MEMBRANE SIGNALING%REACTOME DATABASE ID RELEASE 76%9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling SRF FOXO3 PTK2 UHMK1 BCL2 TGFA CCND1 EGF FOS EPGN CREB1 HBEGF AREG ELK1 MAPK1 EGFR EREG AKT2 BTC CDKN1B XPO1 MAPK3 AKT1 AKT3 ACTIVATED NTRK3 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 76%9034793 Activated NTRK3 signals through PLCG1 PLCG1 NTRK3 NTF3 MATURATION OF PROTEIN 3A%REACTOME DATABASE ID RELEASE 76%9683673 Maturation of protein 3a ST3GAL4 ST6GALNAC3 ST6GALNAC4 ST3GAL3 ST3GAL1 ST3GAL2 3a ST6GAL1 ST6GALNAC2 GALNT1 PHASE I - FUNCTIONALIZATION OF COMPOUNDS%REACTOME%R-HSA-211945.5 Phase I - Functionalization of compounds MAOB MTARC2 MTARC1 ADH7 ADH5 ADH6 ADH4 CYB5R3 CYP2B6 CYP4F2 CYP4F3 CYP4F8 CYP2S1 CYP1A1 CYP21A2 AHRR ADH1C ADH1B ADH1A CYP26A1 CYP27B1 CYP11B1 PTGS1 CYP26B1 CYP2A13 CYP24A1 CYP26C1 CYP2F1 CYP2R1 CBR3 CYP2C9 AOC3 CYP2C8 ARNT2 CYP2D6 NQO2 CYP1A2 AOC1 CYP2E1 AOC2 CYP3A4 FMO1 FMO2 CYP2W1 AADAC HSP90AB1 PTGES3 AHR AIP ALDH3A1 CYP4F22 CYP2C19 CYP2C18 CYP19A1 POMC CYP11A1 MAOA CYP2J2 EPHX1 CYP4F11 CYP4F12 CYP11B2 TBXAS1 CYP4A22 ALDH2 CYP4V2 FMO3 CYP4A11 CYP3A43 ARNT CYP2A7 CYP2A6 ALDH1A1 ACSS2 CYP3A5 BPHL CYP3A7 ALDH1B1 CYP51A1 RXRA ACSS1 CYB5B CYP4B1 CYP46A1 CYP7A1 PTGIS NR1H4 CYP7B1 CYP8B1 CYP27A1 CYP39A1 CES3 NCOA1 NCOA2 FDXR CYP1B1 CMBL POR CYP2U1 FDX1 PAOX FDX2 CES2 CES1 STAT6-MEDIATED INDUCTION OF CHEMOKINES%REACTOME DATABASE ID RELEASE 76%3249367 STAT6-mediated induction of chemokines STAT6 STING1 TBK1 RESOLUTION OF D-LOOP STRUCTURES THROUGH HOLLIDAY JUNCTION INTERMEDIATES%REACTOME%R-HSA-5693568.1 Resolution of D-loop Structures through Holliday Junction Intermediates BLM BRIP1 ATM BARD1 BRCA1 EXO1 RMI2 MUS81 SLX4 EME1 RMI1 EME2 BRCA2 GEN1 TOP3A RAD51AP1 SLX1B XRCC2 SPIDR WRN XRCC3 PALB2 RBBP8 RAD51D MRE11 RAD51 KAT5 NBN RAD50 RAD51B RAD51C DNA2 GLUCOCORTICOID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%194002 Glucocorticoid biosynthesis CYP11B2 CYP17A1 POMC CYP21A2 HSD11B1 CYP11B1 HSD11B2 HSD3B2 HSD3B1 SERPINA6 SYNTHESIS, SECRETION, AND DEACYLATION OF GHRELIN%REACTOME%R-HSA-422085.2 Synthesis, secretion, and deacylation of Ghrelin UCN GH1 PCSK1 ACHE GCG SPCS3 BCHE SPCS2 MBOAT4 SPCS1 IGF1 LEP PLA2G7 SEC11A SEC11C KLF4 CRHR2 INS DEFECTIVE PMM2 CAUSES PMM2-CDG (CDG-1A)%REACTOME DATABASE ID RELEASE 76%4043911 Defective PMM2 causes PMM2-CDG (CDG-1a) PMM2 SIGNALING BY PDGFR IN DISEASE%REACTOME DATABASE ID RELEASE 76%9671555 Signaling by PDGFR in disease GOLGA4 FIP1L1 STAT1 HRAS PDGFRA KDR PIK3CB STRN PIK3CA SOS1 NRAS PIK3R1 ETV6 WDR48 KANK1 STAT3 BIN2 PIK3R2 THE PROTON BUFFERING MODEL%REACTOME%R-HSA-167827.2 The proton buffering model SLC25A27 UCP3 UCP2 UCP1 SLC25A14 ESSENTIAL FRUCTOSURIA%REACTOME%R-HSA-5657562.3 Essential fructosuria KHK SIGNALING BY NTRK1 (TRKA)%REACTOME%R-HSA-187037.2 Signaling by NTRK1 (TRKA) NGF PPP2R1B BRAF PPP2R5D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DNM1 DNM2 PPP2CA CRKL PPP2CB DNM3 RRAD ASCL1 LYL1 JUND EGR3 EGR4 FOSL1 ARC SGK1 ID2 ID4 FOSB ID3 KIDINS220 PPP2R1A TRIB1 CLTC CDK5R2 PIK3R1 JUNB RAPGEF1 ADORA2A RALA PIK3R2 CDK5R1 NTRK1 NTRK2 ADCYAP1 ADCYAP1R1 CDK5 MAP2K1 MAP2K2 YWHAB STAT3 SHC3 DUSP4 TPH1 DUSP3 VRK3 DUSP6 SRF TCF12 DUSP7 MAPK7 MAPKAPK2 CREB1 MAPK14 MAPK11 ATF2 SHC1 ID1 PIK3CA PLCG1 SOS1 FOS MEF2D CHD4 EP300 CLTA AP2A1 AP2A2 SHC2 RALGDS DNAL4 RALB RIT1 RIT2 AP2M1 REST NAB1 NAB2 MAP2K5 CRK EGR2 F3 AP2S1 SH3GL3 ATF1 EGR1 MAPK12 AP2B1 MAPK13 IRS1 MAPKAPK3 SH3GL2 HRAS IRS2 PIK3CB VGF NRAS RAP1A FRS2 RHOA DEFECTIVE SLC16A1 CAUSES SYMPTOMATIC DEFICIENCY IN LACTATE TRANSPORT (SDLT)%REACTOME%R-HSA-5619070.1 Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT) BSG SLC16A1 SIGNALING BY LIGAND-RESPONSIVE EGFR VARIANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%5637815 Signaling by Ligand-Responsive EGFR Variants in Cancer UBB HSP90AA1 CDC37 HRAS UBC SHC1 GAB1 RPS27A PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 UBA52 EGFR CBL DEFECTIVE MPDU1 CAUSES MPDU1-CDG (CDG-1F)%REACTOME DATABASE ID RELEASE 76%4687000 Defective MPDU1 causes MPDU1-CDG (CDG-1f) MPDU1 DEFECTIVE SLC5A7 CAUSES DISTAL HEREDITARY MOTOR NEURONOPATHY 7A (HMN7A)%REACTOME%R-HSA-5619114.1 Defective SLC5A7 causes distal hereditary motor neuronopathy 7A (HMN7A) SLC5A7 CASP8 ACTIVITY IS INHIBITED%REACTOME%R-HSA-5218900.2 CASP8 activity is inhibited FADD CRMA FASLG SPI-2 FAS CASP8 TRADD TNFSF10 TNFRSF10B RIPK1 TNFRSF10A TRAF2 TP53 REGULATES TRANSCRIPTION OF DEATH RECEPTORS AND LIGANDS%REACTOME%R-HSA-6803211.1 TP53 Regulates Transcription of Death Receptors and Ligands TNFRSF10D TNFRSF10C TP53 TP73 IGFBP3 PPP1R13B TP53BP2 FAS TP63 TNFRSF10B TMEM219 TNFRSF10A SHC-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428933.1 SHC-related events triggered by IGF1R IGF1 HRAS IGF2 SOS1 NRAS IGF1R RHOBTB2 GTPASE CYCLE%REACTOME%R-HSA-9013418.2 RHOBTB2 GTPase cycle HSP90AA1 TMOD3 CCT6A CDC37 TXNL1 MSI2 ACTN1 CCT2 PHIP CUL3 RHOBTB2 SRRM1 TRA2B STK38 MYO6 ACTG1 DDX39B HNRNPC CCT7 HSP90AB1 RBMX TWF1 DBN1 INITIATION OF NUCLEAR ENVELOPE (NE) REFORMATION%REACTOME%R-HSA-2995383.5 Initiation of Nuclear Envelope (NE) Reformation PPP2CA BANF1 LMNB1 LBR VRK1 EMD LEMD2 KPNB1 PPP2R1A LEMD3 ANKLE2 CDK1 PPP2R2A SIRT2 CCNB2 CCNB1 NEDDYLATION%REACTOME%R-HSA-8951664.2 Neddylation SOCS6 SOCS5 WDTC1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 CCDC22 KBTBD13 COMMD10 TULP4 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 FBXL21P ASB15 ASB16 FBXL20 DCAF16 DCAF17 ASB10 FEM1C DCAF10 DCAF11 FEM1A FEM1B FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 NEURL2 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 BTRC SKP1 FBXW11 FBXL7 UBA3 UBE2M CAND1 UBA52 FBXL18 CUL1 UBB UBC RPS27A ELOB ELOC COMMD9 COMMD3 UBE2D2 UBE2D3 UBE2D1 FBXO32 PSMD8 NEDD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 WDR5 PSMA3 PSMA4 RBBP7 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 RBBP5 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 CUL5 DDB1 PSMC1 PSMC2 COPS7B COPS7A CUL4A COPS3 COPS6 COPS5 ERCC8 COPS8 CUL4B KCTD6 KEAP1 DCAF7 DTL FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 FBXW2 UCHL3 LRRC41 FBXL3 FBXL5 HIF3A CUL2 VHL SENP8 COP1 CUL7 DDB2 RBX1 SKP2 LRR1 CCNF DCAF8 DCAF5 DCAF4 DCAF6 FBXO7 FBXO9 WSB1 WSB2 FBXO2 OBSL1 DCUN1D5 EPAS1 DCUN1D3 DCUN1D4 DCUN1D1 HIF1A DCUN1D2 SOCS3 COMMD8 PUM2 CUL3 BIRC5 FBXL8 GPS1 FBXL4 DDA1 ANKRD9 COPS4 UBXN7 COMMD2 COPS2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 GAN KLHL2 KLHL3 SPSB3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 CCDC8 KBTBD8 SPSB4 FBXO27 FBXO21 FBXO22 FBXW12 CISH FBXW8 FBXO17 KBTBD7 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 CUL9 KLHL11 KLHL13 FBXO44 DCAF13 FBXO41 SOCS2 FBXO40 BTBD1 UBD NAE1 HISTAMINE RECEPTORS%REACTOME%R-HSA-390650.2 Histamine receptors HRH3 HRH2 HRH4 HRH1 DEREGULATED CDK5 TRIGGERS MULTIPLE NEURODEGENERATIVE PATHWAYS IN ALZHEIMER'S DISEASE MODELS%REACTOME DATABASE ID RELEASE 76%8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models FOXO3 CDC25C GOLGA2 BCL2L11 CDC25B JUN CAPNS1 SOD2 FASLG LMNB1 CAPNS2 YWHAE PRDX2 PRDX1 CAPN2 CAPN1 CAST CDK5 APP CDC25A CDK5R1 PI5P REGULATES TP53 ACETYLATION%REACTOME%R-HSA-6811555.2 PI5P Regulates TP53 Acetylation TP53 PIP4K2A EP300 PIP4K2B PIN1 PIP4K2C MAP2K6 ING2 PIP4P1 DEFECTIVE CD320 CAUSES METHYLMALONIC ACIDURIA%REACTOME DATABASE ID RELEASE 76%3359485 Defective CD320 causes methylmalonic aciduria CD320 TCN2 TOLL LIKE RECEPTOR 3 (TLR3) CASCADE%REACTOME%R-HSA-168164.3 Toll Like Receptor 3 (TLR3) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 CASP8 FOS RIPK1 PPP2R5D FADD HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 TANK PPP2CA PPP2CB UBE2D2 UBE2D3 TBK1 PPP2R1A IKBKE UBE2D1 BTRC IRF3 RIPK3 TRAF3 NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 TLR3 NFKBIB FBXW11 SAA1 TICAM1 IRF7 BIRC2 UBA52 MAP2K1 BIRC3 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA RELA RPS27A IKBKG MAPK9 NFKB2 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 RNA POLYMERASE III TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73980.3 RNA Polymerase III Transcription Termination POLR3K POLR2L CRCP NFIX POLR3GL SSB NFIA POLR3A NFIB NFIC POLR3B POLR2E POLR3C POLR1C POLR2F POLR3D POLR3E POLR1D POLR2H POLR3F POLR3G POLR3H POLR2K G1 S-SPECIFIC TRANSCRIPTION%REACTOME%R-HSA-69205.3 G1 S-Specific Transcription CCNA1 HDAC1 TK1 CCNE1 TYMS RBBP4 E2F6 LIN54 RBL2 POLA1 RBL1 LIN52 PCNA CDC45 E2F4 LIN37 LIN9 E2F5 DHFR TFDP1 ORC1 TFDP2 E2F1 CDT1 CDC6 RRM2 CDK1 FBXO5 ZBP1(DAI) MEDIATED INDUCTION OF TYPE I IFNS%REACTOME DATABASE ID RELEASE 76%1606322 ZBP1(DAI) mediated induction of type I IFNs IKBKB MYD88 CHUK NFKBIA RELA TICAM1 NFKB2 IKBKG TBK1 RIPK1 IRF3 RIPK3 DHX9 NFKB1 ZBP1 NKIRAS1 NKIRAS2 NLRP4 DTX4 TLR3 NFKBIB DDX58 IFIH1-MEDIATED INDUCTION OF INTERFERON-ALPHA BETA%REACTOME%R-HSA-168928.8 DDX58 IFIH1-mediated induction of interferon-alpha beta CREBBP CASP8 IFNB1 SIKE1 RIPK1 TRAF2 FADD HMGB1 APP TOMM70 TANK HSP90AA1 OTUD5 NLRX1 UBA7 UBE2D2 EP300 UBE2D3 NLRC5 TNFAIP3 UBE2L6 IFNA13 HERC5 IFNA14 TBK1 IFNA16 IFNA17 RNF216 PCBP2 IKBKE ATG5 ISG15 UBE2D1 ATG12 IFNA10 CYLD RNF125 IRF3 ITCH TRAF3 TAX1BP1 DHX58 NFKB1 PIN1 NKIRAS1 TKFC UBE2K NKIRAS2 NFKBIB HSP90AB1 SAA1 IFNA21 IRF7 UBA52 IFNA5 IFNA4 IFNA7 IFNA6 IFIH1 UBB IFNA2 IKBKB RNF135 MAVS CHUK UBC DDX58 NFKBIA IFNA8 CASP10 RELA TRIM25 RPS27A IKBKG NFKB2 MAP3K1 AGER S100A12 S100B TRAF6 NOSIP MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 76%203754 NOSIP mediated eNOS trafficking NOS3 NOSIP RHESUS GLYCOPROTEINS MEDIATE AMMONIUM TRANSPORT.%REACTOME%R-HSA-444411.1 Rhesus glycoproteins mediate ammonium transport. RHAG RHBG RHCG CELLULAR RESPONSE TO HYPOXIA%REACTOME%R-HSA-1234174.2 Cellular response to hypoxia CREBBP ELOB ELOC RBX1 HIGD1A CA9 UBE2D2 EP300 UBE2D3 CITED2 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 HIF3A PSMD4 LIMD1 PSMD5 CUL2 PSMD2 VHL PSMD3 EGLN1 PSMD1 EGLN3 PSMA5 EGLN2 PSMA6 WTIP PSMA3 EPAS1 PSMA4 PSMA1 HIF1A PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 AJUBA PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 VEGFA PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 EPO PSMC2 ARNT HIF1AN SLIT2:ROBO1 INCREASES RHOA ACTIVITY%REACTOME DATABASE ID RELEASE 76%8985586 SLIT2:ROBO1 increases RHOA activity ROBO1 RHOA SLIT2 MYO9B SELENOAMINO ACID METABOLISM%REACTOME DATABASE ID RELEASE 76%2408522 Selenoamino acid metabolism CBS IARS1 TXNRD1 CTH SCLY RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 SEPHS2 RPS17 RPS16 RPL18A RPS19 RPS18 SECISBP2 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 LARS1 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 AIMP1 RPL12 RPL11 AIMP2 RPL36A RPS27L RPS4Y1 RPS15A RPL14 EPRS1 RPS3 PAPSS2 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 QARS1 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 EEF1E1 RPS23 AHCY KARS1 PAPSS1 GNMT HNMT RARS1 MAT1A NNMT EEFSEC SEPSECS PSTK MARS1 DARS1 INMT SARS1 HH MUTANTS ABROGATE LIGAND SECRETION%REACTOME%R-HSA-5387390.4 Hh mutants abrogate ligand secretion DERL2 ERLEC1 SHH OS9 HHAT DHH IHH SYVN1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 PSME3 PSME4 SEL1L PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ORGANIC CATION ANION ZWITTERION TRANSPORT%REACTOME%R-HSA-549132.1 Organic cation anion zwitterion transport SLC22A7 RUNX1 SLC22A6 SLC22A4 SLC22A3 RSC1A1 SLC22A15 SLC22A5 SLC22A12 SLC22A11 SLC22A16 SLC22A18 SLC22A2 SLC22A1 SLC22A8 ACTIVATION, TRANSLOCATION AND OLIGOMERIZATION OF BAX%REACTOME DATABASE ID RELEASE 76%114294 Activation, translocation and oligomerization of BAX BID BAX CARNITINE SYNTHESIS%REACTOME%R-HSA-71262.2 Carnitine synthesis TMLHE BBOX1 ALDH9A1 SHMT1 DISEASES OF PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 76%9645723 Diseases of programmed cell death FOXO3 BCL2L11 CDKN2A PRIM2 PRIM1 CASP8 POLA1 TRADD POLA2 RIPK1 GSDME TRAF2 FADD APP H2AX H2AB1 H2AC19 H2AC14 H2BC21 YWHAE H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 CDC25A H2AJ H2BC15 H2BC11 CDK5R1 CDC25C CDC25B C1QBP H3C15 FASLG RBBP4 H2BS1 RBBP7 DNMT1 H2AZ1 CDK5 H2BC9 H2AZ2 EZH2 H4C9 H2BC8 H2BC5 DNMT3B H2BC3 EED H2BC1 H2AC20 GOLGA2 SUZ12 CAPNS1 JUN SOD2 LMNB1 CAPNS2 PRDX2 PRDX1 CAPN2 CAPN1 CAST REGULATION OF GENE EXPRESSION IN EARLY PANCREATIC PRECURSOR CELLS%REACTOME%R-HSA-210747.1 Regulation of gene expression in early pancreatic precursor cells PTF1A ONECUT3 ONECUT1 NKX6-1 PDX1 HNF1B FGF10 FMO OXIDISES NUCLEOPHILES%REACTOME%R-HSA-217271.2 FMO oxidises nucleophiles FMO3 FMO1 FMO2 VOLTAGE GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296072.2 Voltage gated Potassium channels KCNA5 KCNA6 KCNA7 KCNB1 KCNQ2 KCNB2 KCNQ3 KCNS1 KCNS2 KCNG1 KCNS3 KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 KCNQ4 KCNH3 KCNH4 KCNH5 KCNH6 KCNH7 KCNH8 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNF1 KCNC1 KCNC2 KCNC3 KCNC4 KCND1 KCND2 KCND3 KCNAB1 KCNAB2 KCNAB3 KCNA10 KCNA1 KCNA2 KCNA3 KCNA4 HDR THROUGH MMEJ (ALT-NHEJ)%REACTOME DATABASE ID RELEASE 76%5685939 HDR through MMEJ (alt-NHEJ) MRE11 LIG3 XRCC1 RAD50 NBN PARP1 POLQ FEN1 PARP2 RBBP8 ACTIVATED NTRK3 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9603381.1 Activated NTRK3 signals through PI3K PIK3R1 IRS1 PIK3CA SRC NTRK3 NTF3 PRESYNAPTIC PHASE OF HOMOLOGOUS DNA PAIRING AND STRAND EXCHANGE%REACTOME%R-HSA-5693616.2 Presynaptic phase of homologous DNA pairing and strand exchange RHNO1 BLM BRIP1 ATRIP ATM BARD1 RAD17 RAD9B ATR RAD9A BRCA1 EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 RMI1 BRCA2 TOP3A XRCC2 WRN RBBP8 RAD51D MRE11 RAD51 RPA1 CHEK1 RPA2 KAT5 NBN RAD50 RPA3 RAD51B HUS1 RAD1 RAD51C DNA2 ACTIVATION OF NIMA KINASES NEK9, NEK6, NEK7%REACTOME%R-HSA-2980767.2 Activation of NIMA Kinases NEK9, NEK6, NEK7 PLK1 NEK9 NEK6 NEK7 CDK1 CCNB2 CCNB1 DEFECTIVE COFACTOR FUNCTION OF FVIIIA VARIANT%REACTOME DATABASE ID RELEASE 76%9672396 Defective cofactor function of FVIIIa variant F9 F8 F10 DNA METHYLATION%REACTOME DATABASE ID RELEASE 76%5334118 DNA methylation H3C15 H2BS1 DNMT1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 DNMT3L H2BC5 DNMT3B H2BC3 H2BC1 H2AX H2AB1 H2AC20 UHRF1 H2AC19 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CLASS I MHC MEDIATED ANTIGEN PROCESSING & PRESENTATION%REACTOME DATABASE ID RELEASE 76%983169 Class I MHC mediated antigen processing & presentation ATG7 UBE2V1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 KBTBD13 FCGR1B ASB13 ASB14 RNF213 ASB11 RNF7 NCF1 ASB12 NCF2 ASB17 SNAP23 ASB18 NCF4 FBXL22 FBXL21P ASB15 ASB16 FBXL20 MIB2 ASB10 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 CYBB ASB6 CYBA ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 BTRC VAMP3 SEC22B SKP1 CBLB DCAF1 SEC23A HERC4 RNF115 FBXW11 HERC3 RNF114 HERC1 HERC6 RNF126 HECW2 CBLL2 TRIM11 ANAPC13 UBE2J1 RNF217 FBXL7 HACE1 MEX3C SEC24B UBAC1 UBA3 SEC24A DZIP3 RNF220 UBE2M DET1 LRSAM1 UBA52 TRIM9 TRIM4 ARIH2 PDIA3 RNF144B RNF138 RNF130 FBXL18 RLIM CALR TRIP12 SEC24D UBE2D4 SEC24C HLA-H UBE3C CUL1 HLA-B UBE3D HLA-C LTN1 HLA-F RNF19B HLA-G UBE3A UBR4 HLA-E UBE3B UBB NPEPPS RNF19A AREL1 UBE2E2 UBC UBE4A TRAIP RPS27A UBA5 RNF111 UBR2 UBR1 LONRF1 GLMN UBOX5 UBE2U RNF182 UBE2O TPP2 ITGAV BLMH TRIM71 RNF14 UFL1 UBE2V2 UBE2Q1 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 MGRN1 RNF6 FCGR1A RNF4 RCHY1 ZNRF1 ZNRF2 HECTD1 HECTD2 ELOB HECTD3 ELOC TRIM41 SMURF2 ERAP2 RNF25 ERAP1 B2M TRIM39 HLA-A LNX1 TRIM36 SEC31A TRIM37 CTSS CTSL SIAH1 RBCK1 UBA7 UBE2D2 UBE2D3 UBE2L6 NEDD4 HERC5 MKRN1 STUB1 SEC13 ANAPC7 UBE2C UBE2E1 UBE2D1 TRIM63 ANAPC10 ANAPC11 CDC23 HUWE1 UBE2S CDC26 SOCS1 CDC16 FBXO32 CDC27 UBE2K ANAPC4 ANAPC5 MYLIP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 FGB PSMD1 FGA PSMA5 PSMA6 TRIM21 PSMA3 PSMA4 PSMA1 PSMA2 FGG PSME3 SAR1B PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 TRIM32 IKBKB PSMB3 PSMB1 PSMF1 CHUK PSMB8 PSMB9 SEM1 IKBKG PSMC5 PSMC6 PSMC3 PSMC4 CUL5 TLR1 PSMC1 PSMC2 S100A9 S100A8 TLR2 KCTD6 KEAP1 UBE2B FBXO4 FBXO6 RNF123 UBE2Z UBE2L3 UBE2Q2 FBXW4 TAP2 FBXW5 TAP1 SIAH2 CD207 FBXW10 UBE2E3 SEC61A2 MRC2 FBXW7 CDC34 FBXW9 SEC61A1 SEC61G UBE2R2 SEC61B FBXW2 TAPBP UBA6 NEDD4L UBE2J2 UBE2H UBE2G1 UBE2A UBE2G2 LRRC41 RNF41 UBE2W PRKN UBA1 RNF34 FBXL3 FBXL5 CANX SH3RF1 CUL2 VHL HERC2 WWP1 CDC20 CUL7 RBX1 S100A1 HMGB1 HSPA5 TIRAP mip BTK porB TLR6 CD36 SKP2 LNPEP FZR1 ITCH LRR1 CCNF MYD88 FBXO7 VAMP8 FBXO9 WSB1 LY96 FBXO2 CD14 TLR4 SOCS3 CUL3 FBXL8 FBXL4 MRC1 RBBP6 GAN KLHL2 KLHL3 STX4 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 KBTBD7 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 SMURF1 KLHL42 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2N ITGB5 INTERLEUKIN-38 SIGNALING%REACTOME DATABASE ID RELEASE 76%9007892 Interleukin-38 signaling IL1RL2 IL1RAPL1 IL1F10 MAPK8 FGFR1 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190242.2 FGFR1 ligand binding and activation FGF23 FGF22 FGF1 FGF2 FGF3 FGF4 FGF6 ANOS1 FGF10 FGF9 FGF20 DSCAM INTERACTIONS%REACTOME%R-HSA-376172.1 DSCAM interactions MAPK12 RAC1 MAPK13 DSCAM MAPK14 MAPK11 PAK1 MAPK8 DSCAML1 DCC NTN1 MULTIFUNCTIONAL ANION EXCHANGERS%REACTOME%R-HSA-427601.2 Multifunctional anion exchangers SLC26A7 SLC26A9 SLC26A6 SLC26A2 SLC26A4 SLC26A3 SLC5A12 SLC26A1 SLC26A11 STING MEDIATED INDUCTION OF HOST IMMUNE RESPONSES%REACTOME%R-HSA-1834941.3 STING mediated induction of host immune responses CGAS DDX41 TRIM21 TBK1 PRKDC NLRC3 MRE11 IFI16 STAT6 XRCC6 XRCC5 TREX1 IRF3 STING1 NLRP4 DTX4 INTERLEUKIN-9 SIGNALING%REACTOME DATABASE ID RELEASE 76%8985947 Interleukin-9 signaling STAT5A STAT5B STAT1 IL9 IL2RG IL9R JAK3 STAT3 JAK1 DEFECTIVE SLC11A2 CAUSES HYPOCHROMIC MICROCYTIC ANEMIA, WITH IRON OVERLOAD 1 (AHMIO1)%REACTOME DATABASE ID RELEASE 76%5619048 Defective SLC11A2 causes hypochromic microcytic anemia, with iron overload 1 (AHMIO1) SLC11A2 FRS2-MEDIATED ACTIVATION%REACTOME%R-HSA-170968.5 Frs2-mediated activation CRKL NGF MAP2K1 RAPGEF1 BRAF FRS2 MAP2K2 YWHAB MAPK1 MAPK3 RAP1A SIGNALING BY SCF-KIT%REACTOME%R-HSA-1433557.4 Signaling by SCF-KIT SOCS6 CMA1 PIK3CA SH2B3 SH2B2 SOS1 FES GRAP2 LCK GRB7 KIT PTPRU FYN FER STAT3 TEC GRAP VAV1 LYN YES1 STAT5A PRKCA STAT5B STAT1 HRAS MMP9 NRAS PTPN11 RAC1 PIK3R1 JAK2 PIK3R3 CHEK1 GRB10 GAB2 SOCS1 PTPN6 CBL PIK3R2 METABOLISM OF ANGIOTENSINOGEN TO ANGIOTENSINS%REACTOME%R-HSA-2022377.5 Metabolism of Angiotensinogen to Angiotensins CMA1 ATP6AP2 CTSZ CTSD ACE2 CPB2 CPA3 ENPEP CPB1 ACE AGT GZMH ANPEP CTSG AOPEP MME REN CES1 CELL CYCLE CHECKPOINTS%REACTOME%R-HSA-69620.2 Cell Cycle Checkpoints YWHAE PPP2R1A YWHAG GTSE1 CDC25C PKMYT1 DYNLL1 CKAP5 KIF18A MAPRE1 CDC7 UBA52 PAFAH1B1 DYNC1I2 CENPF CCNB2 CCNB1 UBB UBC RPS27A CLASP1 DYNC1H1 NDE1 PLK1 UBE2V2 CDK1 ZW10 PIAS4 KIF2A KIF2C KIF2B RPS27 SUMO1 CENPE WEE1 H2AX H2BC21 H2BU1 ANAPC15 ANAPC16 SEC13 ANAPC7 H2BC17 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 CHEK1 ANAPC10 H2BC14 ANAPC11 CDC25A CDC23 UBE2S H2BC15 CDC26 NUP107 CDC16 CDC27 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DYNC1I1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 H2BS1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 H2BC9 PSME2 PSMD10 ITGB3BP H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 PSMD14 NUP85 H2BC3 PSMD13 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 MRE11 KAT5 NUP133 NBN HUS1 DNA2 RHNO1 BLM PPP2R1B PPP2R5E BRIP1 NUP43 ATRIP RANBP2 BRCC3 BARD1 PPP2R5B CDCA8 PPP2R5A SKA1 PPP2R5D SKA2 RAD17 PPP2R5C NUP37 RAD9B ATR RAD9A BABAM1 BABAM2 YWHAQ BRCA1 UIMC1 NUF2 YWHAH NUDC EXO1 PPP2CA TOPBP1 PPP2CB RFC5 RMI2 INCENP RFC3 RFC4 CENPA RFC2 RMI1 CENPC TOP3A WRN CENPT CENPU RBBP8 CENPH RPA1 CENPI H3-4 RPA2 TAOK1 CENPK CENPL CENPM RAD50 RPA3 CENPN RAD1 DYNLL2 CENPO CENPP CENPQ CENPS CLSPN HERC2 CLIP1 MAD1L1 TP53BP1 NDC80 YWHAB SPDL1 XPO1 RNF168 ABRAXAS1 RANGAP1 NSL1 CDC20 YWHAZ AURKB PPP1CC KNL1 MDC1 DSN1 RCC2 ZWINT AHCTF1 CDKN1A CDKN1B PHF20 NDEL1 CHEK2 ZNF385A CCNA2 CCNA1 CCNE2 CCNE1 TP53 MIS12 COP1 PCBP4 CDKN2A CDK2 MDM2 ATM MDM4 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 SFN MCM7 SGO1 MCM8 SGO2 MCM3 MCM4 MCM5 PMF1 MCM6 MCM2 RNF8 NSD2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDC6 BUB1B BUB3 MAD2L1 BUB1 MCM10 DBF4 BIRC5 CDC45 UBE2N DRUG RESISTANCE OF PDGFR MUTANTS%REACTOME%R-HSA-9674415.1 Drug resistance of PDGFR mutants PDGFRA SHC1 EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 76%1250347 SHC1 events in ERBB4 signaling NRG1 NRG2 HBEGF NRG3 HRAS NRG4 SHC1 EREG BTC SOS1 NRAS GOLGI CISTERNAE PERICENTRIOLAR STACK REORGANIZATION%REACTOME DATABASE ID RELEASE 76%162658 Golgi Cisternae Pericentriolar Stack Reorganization RAB2A RAB1B GOLGA2 GORASP2 BLZF1 GORASP1 PLK1 USO1 MAPK1 CDK1 RAB1A CCNB2 CCNB1 TRANSPORT OF GLYCEROL FROM ADIPOCYTES TO THE LIVER BY AQUAPORINS%REACTOME DATABASE ID RELEASE 76%432030 Transport of glycerol from adipocytes to the liver by Aquaporins AQP9 AQP7 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN G2 CELL CYCLE ARREST%REACTOME%R-HSA-6804114.2 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest GADD45A CDC25C TP53 TFDP1 TFDP2 EP300 RBL2 PRMT1 RBL1 CARM1 PCNA E2F4 BAX CDK1 SFN AURKA ZNF385A CCNB1 FLT3 SIGNALING THROUGH SRC FAMILY KINASES%REACTOME%R-HSA-9706374.1 FLT3 signaling through SRC family kinases SYK FLT3LG FYN HCK FLT3 LCK MET ACTIVATES RAS SIGNALING%REACTOME%R-HSA-8851805.1 MET activates RAS signaling RANBP9 HGF RANBP10 HRAS MET SOS1 NRAS MUC20 MYD88:MAL(TIRAP) CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-166058.3 MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAB1 UBE2V1 PPP2R1B MAP2K6 PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN RPS27A CREB1 MAPK14 MAPK11 ATF2 FOS S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 PELI1 SOCS1 IRAK4 SAA1 MYD88 LY96 FGB FGA CD14 TLR4 FGG ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 SORAFENIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9669936 Sorafenib-resistant KIT mutants KIT ER-PHAGOSOME PATHWAY%REACTOME DATABASE ID RELEASE 76%1236974 ER-Phagosome pathway B2M HLA-A TAP2 TAP1 SEC61A2 S100A1 HMGB1 SEC61A1 SEC61G TIRAP SEC61B mip SNAP23 TAPBP BTK porB TLR6 CD36 VAMP3 SEC22B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 MYD88 PSMD5 VAMP8 PSMD2 PSMD3 FGB LY96 PSMD1 FGA PSMA5 PSMA6 CD14 PSMA3 TLR4 PSMA4 PSMA1 FGG PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PDIA3 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 CALR PSMB10 HLA-H PSMA8 HLA-B PSMB6 HLA-C PSMB7 HLA-F PSMB4 HLA-G PSMB5 STX4 HLA-E PSMB2 UBB IKBKB PSMB3 PSMB1 PSMF1 CHUK UBC PSMB8 PSMB9 RPS27A SEM1 IKBKG PSMC5 PSMC6 PSMC3 PSMC4 TLR1 PSMC1 PSMC2 S100A9 S100A8 TLR2 MAPK1 (ERK2) ACTIVATION%REACTOME DATABASE ID RELEASE 76%112411 MAPK1 (ERK2) activation JAK2 MAP2K2 MAPK1 IL6R JAK1 PTPN11 IL6 TYK2 CHREBP ACTIVATES METABOLIC GENE EXPRESSION%REACTOME DATABASE ID RELEASE 76%163765 ChREBP activates metabolic gene expression ACACA MLX AGPAT1 FASN MLXIPL ACLY ACACB DOPAMINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME DATABASE ID RELEASE 76%212676 Dopamine Neurotransmitter Release Cycle SNAP25 SYT1 UNC13B APBA1 RAB3A SYN3 CPLX1 SYN2 RIMS1 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 VAMP2 PPFIA2 CASK LIN7A SLC18A2 LIN7C SYN1 LIN7B ASSEMBLY OF THE SARS-COV-2 REPLICATION-TRANSCRIPTION COMPLEX (RTC)%REACTOME DATABASE ID RELEASE 76%9694271 Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC) rep MPS IIID - SANFILIPPO SYNDROME D%REACTOME%R-HSA-2206305.2 MPS IIID - Sanfilippo syndrome D GNS ER QUALITY CONTROL COMPARTMENT (ERQC)%REACTOME DATABASE ID RELEASE 76%901032 ER Quality Control Compartment (ERQC) DERL2 UBB RNF5 OS9 UBC RNF185 EDEM2 RPS27A RNF139 SEL1L MAN1B1 UGGT2 UGGT1 UBA52 MARCHF6 EDEM3 EDEM1 AMFR RNF103 TRIM13 SYVN1 VRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 76%192905 vRNP Assembly PA HSP90AA1 PB2 NP PB1 IPO5 DEFECTIVE SLC22A12 CAUSES RENAL HYPOURICEMIA 1 (RHUC1)%REACTOME%R-HSA-5619071.1 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) SLC22A12 LEUKOTRIENE RECEPTORS%REACTOME%R-HSA-391906.2 Leukotriene receptors GPR17 CYSLTR1 CYSLTR2 LTB4R2 LTB4R GLYCOGEN STORAGE DISEASES%REACTOME DATABASE ID RELEASE 76%3229121 Glycogen storage diseases GAA GYG1 UBB UBC GBE1 RPS27A GYG2 NHLRC1 SLC37A4 EPM2A G6PC3 UBA52 GYS2 G6PC1 PPP1R3C GYS1 CYCLIN D ASSOCIATED EVENTS IN G1%REACTOME DATABASE ID RELEASE 76%69231 Cyclin D associated events in G1 CCNE2 CCNE1 PPP2R1B ABL1 CDKN2A CDK2 RBL2 RBL1 E2F4 CCNH UBA52 E2F5 PPP2R3B CUL1 SKP2 LYN PPP2CA CDKN1C PPP2CB UBB RB1 CCND3 TFDP1 UBC CDK6 CCND2 TFDP2 CCND1 RPS27A CDK4 E2F1 CDK7 E2F2 E2F3 CDKN2D CDKN2C MNAT1 PPP2R1A PTK6 JAK2 CDKN2B CDKN1A CDKN1B SKP1 PPP2R2A CKS1B PEPTIDE HORMONE METABOLISM%REACTOME%R-HSA-2980736.2 Peptide hormone metabolism ACE2 TCF7L2 SLC30A7 CTNNB1 PCSK1 SLC30A6 SLC30A8 CDX2 GPR119 DPP4 SPCS3 CGB8 SLC30A5 SPCS2 SPCS1 LEP SEC11A MYO5A SEC11C RAB27A GRP CPA3 ENPEP CPB1 ACE CTSG GZMH ERO1A AOPEP MME REN CTSZ CTSD GNG13 UCN KIF5C KIF5B KIF5A TSHB STX1A GNB3 PCSK2 ACHE GCG ERO1B BCHE MYRIP MBOAT4 CLTRN IGF1 PLA2G7 INHBB INHBA INHBC INHBE LHB GATA4 KLF4 CPE INHA EXOC8 EXOC7 AGT INS ISL1 CMA1 EXOC4 EXOC3 EXOC6 EXOC5 CGA EXOC2 VAMP2 EXOC1 POMC ATP6AP2 GNAT3 GH1 FFAR4 CPB2 FFAR1 GIP PAX6 CRHR2 ANPEP FSHB CES1 DEFECTIVE CYP7B1 CAUSES SPG5A AND CBAS3%REACTOME%R-HSA-5579013.2 Defective CYP7B1 causes SPG5A and CBAS3 CYP7B1 REUPTAKE OF GABA%REACTOME DATABASE ID RELEASE 76%888593 Reuptake of GABA SLC6A11 SLC6A1 SLC6A13 SLC6A12 GSD IB%REACTOME%R-HSA-3229133.2 GSD Ib SLC37A4 FOXO-MEDIATED TRANSCRIPTION OF CELL DEATH GENES%REACTOME%R-HSA-9614657.1 FOXO-mediated transcription of cell death genes CREBBP FOXO3 BCL2L11 NFYA FASLG EP300 NFYB BBC3 NFYC CITED2 FOXO1 DDIT3 STK11 BCL6 PINK1 FOXO4 GLYCOLYSIS%REACTOME DATABASE ID RELEASE 76%70171 Glycolysis PPP2R1B GPI NUP42 NUP43 RAE1 RANBP2 ENO1 ALDOB PRKACG PRKACB GCK NUP35 PPP2R5D NUP37 PGK1 GAPDHS PPP2CA PPP2CB ALDOC ALDOA SEC13 PPP2R1A PRKACA NUP107 NUP188 ADPGK ENO2 ENO3 PGAM1 HK2 TPI1 PGAM2 BPGM PGM2L1 PGP GAPDH PFKFB2 PFKFB1 NUP210 PFKFB4 PFKFB3 PGK2 NUP93 GNPDA1 GNPDA2 PFKM POM121 PFKP NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 GCKR HK3 NUP155 NUP214 NUP153 HK1 NUP62 NDC1 NUP133 PFKL NUP50 NUP54 PHOSPHATE BOND HYDROLYSIS BY NUDT PROTEINS%REACTOME DATABASE ID RELEASE 76%2393930 Phosphate bond hydrolysis by NUDT proteins ADPRM NUDT16 NUDT15 NUDT5 NEGATIVE REGULATION OF FGFR2 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654727 Negative regulation of FGFR2 signaling BRAF MKNK1 SPRY2 UBA52 MAPK1 MAPK3 PPP2CA PPP2CB UBB UBC FGF1 RPS27A FGF2 FGF3 FGF4 FGF6 FGF7 PTPN11 FGF9 FGF20 PPP2R1A FGF23 FGF22 FRS2 FGF16 FGF18 CBL FGF10 PD-1 SIGNALING%REACTOME%R-HSA-389948.2 PD-1 signaling PDCD1 TRAC CD3E TRBC1 LCK PDCD1LG2 CD274 TRBV12-3 TRAV29DV5 TRBV7-9 TRAV19 TRAV8-4 HLA-DQA2 HLA-DQA1 HLA-DRB5 CD4 HLA-DRB4 CSK HLA-DRB3 HLA-DRB1 CD3G CD3D HLA-DPA1 HLA-DQB2 PTPN11 HLA-DQB1 HLA-DPB1 HLA-DRA PTPN6 MITOCHONDRIAL TRANSCRIPTION INITIATION%REACTOME%R-HSA-163282.3 Mitochondrial transcription initiation TFB2M POLRMT TFAM BETA-CATENIN PHOSPHORYLATION CASCADE%REACTOME%R-HSA-196299.1 Beta-catenin phosphorylation cascade PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 FRAT1 FRAT2 OLIGOMERIZATION OF CONNEXINS INTO CONNEXONS%REACTOME%R-HSA-190704.1 Oligomerization of connexins into connexons GJB2 GJB1 GJA1 NUCLEAR IMPORT OF REV PROTEIN%REACTOME%R-HSA-180746.1 Nuclear import of Rev protein NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 RAN NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 NPM1 TPR NUP88 NUP155 NUP214 NUP153 KPNB1 RCC1 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE%REACTOME DATABASE ID RELEASE 76%1660516 Synthesis of PIPs at the early endosome membrane PIK3C2A PIK3R4 MTMR4 PI4K2B VAC14 MTMR10 MTMR2 MTMR12 MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PIK3C3 PI4K2A REGULATION OF FZD BY UBIQUITINATION%REACTOME%R-HSA-4641263.2 Regulation of FZD by ubiquitination LGR5 UBB LGR4 RNF43 RSPO4 FZD8 UBC WNT3A RPS27A FZD5 FZD6 UBA52 USP8 LRP5 ZNRF3 LRP6 RSPO2 FZD4 RSPO3 RSPO1 LGR6 REV-MEDIATED NUCLEAR EXPORT OF HIV RNA%REACTOME DATABASE ID RELEASE 76%165054 Rev-mediated nuclear export of HIV RNA NUP42 NUP210 NUP43 rev RAE1 RANBP2 NUP93 POM121 RAN NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 XPO1 NUP155 RANGAP1 NUP214 NUP153 RCC1 SEC13 NUP62 NDC1 NUP133 RANBP1 NUP107 NUP188 NUP50 NUP54 LONG-TERM POTENTIATION%REACTOME DATABASE ID RELEASE 76%9620244 Long-term potentiation NRG1 GRIN2C CAMK2B CAMK2D CAMK2A CAMK2G ACTN2 GRIA1 GRIN2B NRGN GRIN1 GRIN2D GRIA2 DLG1 DLG2 CALM1 DLG3 LRRC7 SRC DLG4 NEFL GRIN2A RHO GTPASES ACTIVATE IQGAPS%REACTOME DATABASE ID RELEASE 76%5626467 RHO GTPases activate IQGAPs RAC1 IQGAP2 IQGAP1 CDC42 CDH1 CTNNA1 MEN1 CALM1 CTNNB1 CLIP1 IQGAP3 AUTOPHAGY%REACTOME%R-HSA-9612973.2 Autophagy TOMM22 ATG7 NBR1 UBE2V1 CSNK2A1 CHMP2B CHMP2A CSNK2A2 CSNK2B TOMM70 PRKN HSP90AA1 HSPA8 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG2 PLIN2 PRKAB1 PRKAG3 CHMP3 VPS37C VPS37D VPS37A CHMP6 VPS37B CHMP7 TOMM20 DYNLL2 HSP90AB1 HSF1 TOMM40 HDAC6 MVB12B PARK7 UVRAG MVB12A DYNLL1 USP30 LAMP2 UBA52 BECN1 DYNC1I2 TOMM7 TOMM5 TOMM6 UBB HBB UBC RPS27A PCNT DYNC1H1 ARL13B ULK1 CFTR GABARAPL2 MFN1 ATM MFN2 DYNC1LI1 DYNC1LI2 VPS28 IFT88 GABARAP WIPI1 SQSTM1 MAP1LC3B ATG5 ATG12 PINK1 VDAC1 DYNC1I1 VCP EPAS1 PRKAA1 RPTOR MLST8 SLC38A9 TSC2 TSC1 GABARAPL3 MTOR ATG3 GABARAPL1 RRAGA PIK3R4 ATG9B UBAP1 ATG9A RRAGC ATG10 RHEB ATG14 RRAGB ATG13 RNASE1 RRAGD CHMP4C CHMP4B MTMR3 LAMTOR2 ATG101 LAMTOR1 MTERF3 LAMTOR4 CHMP4A GFAP LAMTOR3 EEF1A1 ATG16L1 LAMTOR5 CETN1 MTMR14 WDR45 MAP1LC3A TSG101 MAP1LC3C RB1CC1 FUNDC1 WIPI2 PEX5 ATG4C ATG4B PIK3C3 ATG4A UBE2N ATG4D WDR45B AMBRA1 DEFECTIVE ALG14 CAUSES CONGENITAL MYASTHENIC SYNDROME (ALG14-CMS)%REACTOME%R-HSA-5633231.2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) ALG14 ALG13 INHIBITION OF IFN-BETA%REACTOME DATABASE ID RELEASE 76%168888 Inhibition of IFN-beta NS GABA RECEPTOR ACTIVATION%REACTOME%R-HSA-977443.5 GABA receptor activation GABRB3 GABRB2 GNAL GABRB1 GABRR3 GABRR2 GABRR1 NPTN GABRG3 GABRG2 GABRQ GABRA2 GABRA1 GABRA6 GABRA5 GABRA4 GABRA3 ADCY9 GNG10 GNAI3 GNG12 GNAI1 GNG11 GNAI2 GNG13 GNB2 GNB1 GNB4 ADCY4 GNB3 ADCY3 ADCY2 GNB5 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 ARHGEF9 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 GABBR2 GABBR1 GNAT3 LXRS REGULATE GENE EXPRESSION LINKED TO TRIGLYCERIDE LIPOLYSIS IN ADIPOSE%REACTOME%R-HSA-9031528.1 LXRs regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 RXRA PLIN1 RXRB NR1H3 NEURONAL SYSTEM%REACTOME%R-HSA-112316.7 Neuronal System PLCB3 PLCB1 PRKCB PLCB2 KPNA2 GAD1 GAD2 MAPK1 RPS6KA3 KCNQ4 RPS6KA2 RPS6KA1 MAPK3 NTRK3 GNAI3 SLC1A2 EPB41L1 PRKX EPB41L3 GNAI1 GNAI2 SLC1A6 SLC1A7 CACNG8 CACNG2 CACNG3 STX1A CACNG4 PRKACA PRKCG SLITRK3 SLITRK5 KCNK18 CACNB1 CACNB2 CACNB3 CACNB4 PRKAR2B SNAP25 RAC1 DNAJC5 SRC GJA10 KCNQ2 KCNQ3 IL1RAPL1 CAMK1 ACTN2 CAMKK1 CAMKK2 RASGRF2 KIF17 RASGRF1 GRIN2B NRGN RPS6KA6 GRIN1 GRIN2D CASK GRIA2 DLG1 PANX1 LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIN2A GRIA3 GRIA4 GRIN2C GRIN3B GRIN3A NBEA UNC13B APBA1 SYN3 CPLX1 SYN2 RIMS1 AKAP5 PPFIA1 TSPOAP1 PPFIA4 PPFIA3 PPFIA2 AP2A1 CHRNA9 SHARPIN KCNN2 CHRNB4 SLC5A7 ARHGEF9 SLC1A1 SLC1A3 SHANK3 NSF SLC6A3 SLC22A2 SLC22A1 ABCC8 ABCC9 GABRB3 GABRB2 GNAL GABRB1 SYT2 GABRR3 SYT1 GABRR2 GABRR1 NPTN GABRG3 GABRG2 GABRQ GABRA2 SYT9 GABRA1 KCNJ11 GABRA6 GABRA5 GABRA4 GABRA3 ABAT ARL6IP5 HOMER3 CACNA2D1 KCNMA1 CACNA2D3 EPB41 STXBP1 EPB41L5 CACNA2D2 EPB41L2 TSPAN7 HOMER1 SYN1 GNG10 HOMER2 PPFIBP1 PPFIBP2 GRIK5 GRIK4 GNG12 GRIK1 GNG11 GRIK2 KCNMB1 GNG13 SLC6A4 KCNMB2 PANX2 KCNMB3 SIPA1L1 GNB2 KCNMB4 DLGAP1 HSPA8 PRKAB2 DLGAP3 GNB1 DLGAP2 PRKAA2 PRKAG1 DLGAP4 GNB4 PDPK1 ALDH5A1 PRKAG2 PICK1 GNB3 BEGAIN PRKAB1 CHRND PRKAG3 GLRA1 GNB5 GLRA2 GLRA3 CHRNG GNGT1 CHRNE APBA3 APBA2 SLC6A1 GNGT2 GRIP1 CHRNB2 CHRNB3 GRIP2 NAAA CALM1 SLC18A2 CHRNA1 CHRNA3 CHRNA2 GIT1 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHAT GLS CACNA1B CACNA1A CACNA1E LRRC4B SYT7 LRRTM3 GLUL LRRTM4 GNG3 LRRTM1 LRRTM2 HTR3E GNG2 HTR3C HTR3D GNG5 HTR3A GNG4 SLC6A12 HTR3B GNG7 SLC6A11 LRTOMT IL1RAPL2 GNG8 SHANK2 SHANK1 NLGN3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 NCALD MAOA SLITRK2 COMT SLITRK1 FLOT2 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X PRKCA SYT12 CAMK2B GLRB SLC38A1 CAMK2D SYT10 CAMK2A CAMK2G ALDH2 CREB1 CAMK4 SLC38A2 RTN3 PTPRS PTPRF LRFN3 PTPRD LRFN2 LRFN4 LRFN1 MDM2 PRKACG PRKACB ADCY9 PRKAR1B GJC1 KCNG1 PRKAR1A KCNG2 KCNG3 KCNG4 KCNH1 KCNH2 PRKAR2A KCNH3 KCNH4 KCNH5 FLOT1 KCNH6 KCNK10 KCNH7 KCNH8 KCNK13 KCNK16 KCNK17 KCNQ1 KCNQ5 KCNV1 KCNV2 KCNN1 KCNN3 KCNN4 ADCY4 KCNF1 KCNK6 ADCY3 KCNK7 KCNC1 ADCY2 ADCY1 KCNK9 ACHE KCNC2 ADCY8 KCNC3 ADCY7 BCHE KCNC4 ADCY6 GRIK3 KCND1 ADCY5 KCND2 KCND3 KCNAB1 KCNAB2 SLC18A3 KCNAB3 KCNA10 HCN4 HCN3 KCNA1 KCNA2 KCNA3 SLC6A13 KCNA4 KCNA5 KCNA6 KCNA7 NRG1 GJD2 KCNJ1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 GRM1 KCNJ6 KCNJ10 KCNJ8 KCNB1 GRM5 KCNJ9 KCNJ12 KCNB2 VAMP2 KCNJ14 KCNJ15 KCNJ16 KCNS1 KCNS2 PRKAA1 KCNS3 KCNK1 KCNK2 HCN2 MYO6 KCNK3 GABBR2 KCNK4 HCN1 GABBR1 GNAT3 HRAS RAB3A NRAS DBNL SLC32A1 GRIA1 SLC17A7 GLS2 FATTY ACYL-COA BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%75105 Fatty acyl-CoA biosynthesis ELOVL1 ELOVL5 ACSL6 ACSL1 ELOVL2 ACSL5 ELOVL3 ELOVL6 ACSL3 SLC27A3 HACD1 SCD HACD3 HACD2 HACD4 HTD2 MORC2 ACLY TECRL ACSF3 PPT1 ACACA PPT2 SLC25A1 TECR ELOVL4 ELOVL7 ACSBG1 ACSBG2 HSD17B3 SCD5 HSD17B12 FASN HSD17B8 CBR4 OLAH C-TYPE LECTIN RECEPTORS (CLRS)%REACTOME DATABASE ID RELEASE 76%5621481 C-type lectin receptors (CLRs) CREBBP TAB1 UBE2V1 PPP3R1 CASP8 NFATC1 SYK CDC34 FYN PAK3 BCL10 RPS6KA5 IL1B env ITPR1 ITPR2 ITPR3 PDPK1 BTRC PRKACA MUC5AC PYCARD PAK1 NFKB1 CALM1 SKP1 FBXW11 MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 RELB MUC19 UBA3 MAP3K14 MUC20 NFATC2 MUC21 UBE2M UBA52 MUC5B CARD9 CLEC4C CLEC4D CUL1 LYN MUC13 PRKCD UBB CLEC10A UBC ICAM2 ICAM3 CLEC4A RPS27A CLEC4E CARD11 CLEC7A NFATC3 CLEC6A MALT1 PRKACG PRKACB MUC1 MUC2 FCER1G MUC7 MUC4 MUC6 UBE2D2 EP300 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 AHCYL1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 HRAS CHUK PAK2 NFKBIA PSMB8 RELA PSMB9 SEM1 NFKB2 IKBKG PSMC5 PSMC6 PSMC3 NRAS PSMC4 PSMC1 PSMC2 RAF1 MUCL1 CD209 PPP3CA TRAF6 UBE2N PPP3CB PLCG2 TAB3 MAP3K7 TAB2 SOS-MEDIATED SIGNALLING%REACTOME%R-HSA-112412.3 SOS-mediated signalling IRS1 HRAS IRS2 SOS1 NRAS ACTIVATION OF PPARGC1A (PGC-1ALPHA) BY PHOSPHORYLATION%REACTOME%R-HSA-2151209.1 Activation of PPARGC1A (PGC-1alpha) by phosphorylation MAPK12 PPARGC1A MAPK14 MAPK11 PRKAB2 PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 PI3K EVENTS IN ERBB4 SIGNALING%REACTOME DATABASE ID RELEASE 76%1250342 PI3K events in ERBB4 signaling NRG1 PIK3R1 NRG2 HBEGF NRG3 NRG4 PIK3CA EREG BTC TRANSCRIPTIONAL REGULATION BY RUNX1%REACTOME DATABASE ID RELEASE 76%8878171 Transcriptional regulation by RUNX1 CREBBP CSF2 CBFB PRKCB RUNX1 BMI1 PBRM1 ARID2 AUTS2 IL2 IL3 MYB TCF3 DPY30 RNF2 SPI1 ZFPM1 TAL1 KMT2A GATA3 GATA2 GATA1 MYL9 ABL1 NFE2 PHC2 PHC1 SETD1B SETD1A NFATC2 ITGA2B UBA52 PHC3 ASH2L PML RSPO3 TCF12 UBB CCND3 UBC CDK6 CCND2 RPS27A CCND1 SIN3A ACTL6A CR1 PCGF5 YAP1 RYBP SRC ESR1 CCNH CTSL CTSK H2AX H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 CDK7 H2AC8 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ H2BC15 IFNG H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 WDR5 PSMA3 H2BS1 TJP1 PSMA4 PSMA1 PSMA2 LDB1 PSME3 GP1BA PSME4 H2AZ1 PSME1 H2BC9 PSME2 PSMD10 H2AZ2 H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 SMARCD1 PSMD14 SMARCD2 H2BC3 PSMD13 RBBP5 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 PSMB7 H2AC20 PSMB4 SMARCE1 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SMARCD3 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PRMT6 LMO1 LMO2 LIFR TNFRSF18 KCTD6 CBX8 CBX6 CBX4 CBX2 NR4A3 CSNK2A1 TP73 ARID1A CSNK2A2 ARID1B CSNK2B THBS1 CLDN5 PTPN11 CTLA4 ACTL6B RING1 AXIN1 SIN3B SERPINB13 HIPK2 TNRC6C MOV10 BLK ELF1 ELF2 PAX5 TNRC6A TNRC6B PRKCQ GPAM FOXP3 PRMT1 AGO3 AGO4 AGO1 AGO2 KMT2E KMT2D KMT2C KMT2B SOCS4 ITCH YAF2 PF4 SOCS3 IL2RA SMARCB1 SMARCC1 SMARCC2 OCLN SMARCA2 SMARCA4 LGALS3 TRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 76%6787450 tRNA modification in the mitochondrion MTO1 TRIT1 TRMT61B GTPBP3 HSD17B10 TRMT10C PRORP TRMU MITOTIC PROMETAPHASE%REACTOME%R-HSA-68877.5 Mitotic Prometaphase PPP2R1B PPP2R5E NEK9 NEK6 NEK7 NUP43 RANBP2 PPP2R5B CDCA8 PPP2R5A SKA1 PPP2R5D CSNK2A1 SKA2 PPP2R5C NUP37 CSNK2A2 CSNK2B NUF2 NUDC PPP2CA PPP2CB HSP90AA1 INCENP CEP57 CENPA YWHAE CENPC CETN2 CEP164 CCP110 PCM1 CENPT ACTR1A CENPU TUBA1A PPP2R1A CNTRL CEP250 CENPH NEK2 CENPI PRKACA TAOK1 NINL CENPK CEP290 CENPL CENPM YWHAG CDK5RAP2 OFD1 CENPN DYNLL2 CEP135 CENPO CENPP CENPQ TUBB CENPS CEP131 TUBGCP2 HAUS4 HAUS3 SMC3 CSNK1D HAUS6 TUBGCP5 HAUS5 CSNK1E TUBGCP6 TUBGCP3 TUBG1 TUBGCP4 DYNLL1 CKAP5 HAUS2 TUBA4A CLIP1 RAD21 KIF18A HAUS1 AKAP9 MAD1L1 TUBG2 CEP63 MZT2B MAPRE1 NDC80 STAG1 MZT2A SFI1 STAG2 NME7 SDCCAG8 PAFAH1B1 SMC1A DYNC1I2 SPDL1 DCTN2 SSNA1 XPO1 DCTN3 MZT1 CENPF RANGAP1 CCNB2 CCNB1 HAUS8 NSL1 HAUS7 CDC20 PRKAR2B CEP70 CEP72 CEP192 AURKB PCNT CEP76 PPP1CC CLASP1 CEP78 KNL1 PLK4 DYNC1H1 ODF2 CEP152 NDE1 DSN1 PLK1 TUBB4B EML4 RCC2 TUBB4A ZWINT NUMA1 NEDD1 CENPJ AHCTF1 ALMS1 CDK1 CEP41 CEP43 ZW10 NDEL1 KIF2A KIF2C MIS12 KIF2B RPS27 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L CENPE ZWILCH KNTC1 SGO1 SGO2 PMF1 BUB1B BUB3 SEC13 MAD2L1 BUB1 NUP107 NCAPG NCAPD2 SMC4 NCAPH SMC2 DYNC1I1 BIRC5 ITGB3BP NUP160 NUP85 CLASP2 CDCA5 NUP133 PDS5B PDS5A WAPL ABORTIVE ELONGATION OF HIV-1 TRANSCRIPT IN THE ABSENCE OF TAT%REACTOME DATABASE ID RELEASE 76%167242 Abortive elongation of HIV-1 transcript in the absence of Tat CTDP1 NCBP2 POLR2L SUPT4H1 SUPT5H GTF2F1 NELFB GTF2F2 NELFCD NELFA NELFE POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I NCBP1 POLR2J POLR2K TRANSPORT OF MATURE MRNAS DERIVED FROM INTRONLESS TRANSCRIPTS%REACTOME%R-HSA-159234.2 Transport of Mature mRNAs Derived from Intronless Transcripts FIP1L1 NUP42 NUP210 NUP43 RAE1 CPSF1 RANBP2 NUP93 CPSF4 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 SLBP NUP155 EIF4E CPSF3 NCBP1 CPSF2 NUP214 NUP153 NCBP2 SYMPK NXF1 SEC13 WDR33 NUP62 NDC1 ALYREF NUP133 NUP107 NUP188 NUP50 NUP54 HORMONE LIGAND-BINDING RECEPTORS%REACTOME DATABASE ID RELEASE 76%375281 Hormone ligand-binding receptors TSHB GPHB5 GNRHR2 GNRHR FSHR CGA GPHA2 TSHR LHB LHCGR GNRH2 GNRH1 FSHB DEFECTIVE SLC5A5 CAUSES THYROID DYSHORMONOGENESIS 1 (TDH1)%REACTOME%R-HSA-5619096.1 Defective SLC5A5 causes thyroid dyshormonogenesis 1 (TDH1) SLC5A5 FORMATION OF SENESCENCE-ASSOCIATED HETEROCHROMATIN FOCI (SAHF)%REACTOME%R-HSA-2559584.1 Formation of Senescence-Associated Heterochromatin Foci (SAHF) RB1 TP53 ASF1A H1-1 H1-0 H1-3 H1-2 LMNB1 H1-5 H1-4 HIRA UBN1 EP400 HMGA1 HMGA2 CABIN1 FCERI MEDIATED NF-KB ACTIVATION%REACTOME DATABASE ID RELEASE 76%2871837 FCERI mediated NF-kB activation TAB1 UBE2V1 V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 CDC34 V5-6 BCL10 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 PDPK1 V4-6 V4-2 V4-1 IGKV1-5 IGLV BTRC NFKB1 SKP1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 FBXW11 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 UBA52 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 CUL1 IGKV1D-16 IGKV1D-12 LYN IGLV1-51 IGLV2-23 UBB IGKV3-20 IGHV4-34 IGHV1-2 UBC IGHV4-39 IGKV2-29 RPS27A IGKV2-28 CARD11 IGLC3 IGLC1 IGLC2 V1-9 V1-7 MALT1 V1-5 V1-3 IGKV3D-20 RASGRP4 PRKCQ IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 IGHE UBE2D2 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 IGHV3-23 PSMB4 PSMB5 IGLV2-8 PSMB2 IKBKB PSMB3 IGKV1-16 PSMB1 PSMF1 IGKV1-17 CHUK IGKV1-12 NFKBIA PSMB8 IGHV3-7 RELA PSMB9 IGHV3-9 SEM1 IKBKG PSMC5 IGHV3-30 PSMC6 V2-17 RASGRP2 PSMC3 IGHV3-33 RASGRP1 PSMC4 PSMC1 V2-15 PSMC2 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 TRAF6 UBE2N TAB3 MAP3K7 TAB2 AMINO ACID CONJUGATION%REACTOME DATABASE ID RELEASE 76%156587 Amino Acid conjugation ACSM1 ACSM5 ACSM4 ACSM2B GLYATL3 GLYAT GLYATL2 GLYATL1 ACSM2A DNA REPLICATION%REACTOME DATABASE ID RELEASE 76%69306 DNA Replication RFC5 RFC3 RFC4 RFC2 RPA1 RPA2 RPA3 SKP1 CDC7 UBA52 CUL1 UBB UBC POLE RPS27A LIG1 E2F1 E2F2 RFC1 E2F3 POLD3 POLD4 CCNA2 POLD1 CCNA1 POLD2 CCNE2 CCNE1 POLE4 CDK2 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 RBX1 PCNA MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 GMNN PSMD8 PSMD9 PSMD6 PSMD7 MCM10 PSMD4 DBF4 PSMD5 PSMD2 RPA4 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 GINS1 PSME3 GINS2 PSME4 CDC45 PSME1 GINS3 PSME2 GINS4 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FEN1 DNA2 SIGNAL AMPLIFICATION%REACTOME%R-HSA-392518.1 Signal amplification GNA14 P2RY1 GNG3 GNA15 GNG2 GNA13 GNG5 AAMP GNG4 PLA2G4A GNG7 GNA11 GNG8 GNG10 GNAI3 GNG12 GNAI1 GNG11 GNAI2 GNG13 GNAT3 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 TBXA2R P2RY12 GNGT2 MAPK14 NUCLEOTIDE-LIKE (PURINERGIC) RECEPTORS%REACTOME%R-HSA-418038.1 Nucleotide-like (purinergic) receptors P2RY4 P2RY2 P2RY1 GPR17 P2RY12 P2RY13 P2RY10 P2RY11 ADORA3 ADORA2A LPAR6 ADORA2B ADORA1 P2RY14 LPAR4 P2RY6 DEFECTIVE ABCB4 CAUSES PFIC3, ICP3 AND GBD1%REACTOME%R-HSA-5678771.2 Defective ABCB4 causes PFIC3, ICP3 and GBD1 ABCB4 METABOLISM OF VITAMIN K%REACTOME DATABASE ID RELEASE 76%6806664 Metabolism of vitamin K UBIAD1 VKORC1 VKORC1L1 OXIDATIVE DEMETHYLATION OF DNA%REACTOME DATABASE ID RELEASE 76%5221030 Oxidative demethylation of DNA TDG TET2 TET1 TET3 TRNA PROCESSING%REACTOME DATABASE ID RELEASE 76%72306 tRNA processing RPP21 RPP25 TSEN34 DDX1 CSTF2 HSD17B10 RPP14 C2orf49 NUP42 NUP43 RTRAF CPSF1 RAE1 RPP40 RANBP2 CPSF4 XPOT FAM98B RAN NUP35 NUP37 NUP214 TRMU MTO1 TRIT1 TRMT61B GTPBP3 THG1L ALKBH8 TRMT44 PUS3 TYW5 EPRS1 METTL1 TYW3 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B TRMT12 TRMT13 TRMT11 WDR4 NSUN2 NSUN6 QTRT1 DUS2 QTRT2 CTU2 CTU1 URM1 TYW1 LCMT2 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ADAT2 TRMT5 TRMT6 TRMT61A SEC13 TRMT112 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 TRMT10C PRORP ELAC2 TRNT1 NUP62 TP53RK NDC1 POP5 POP7 NUP133 POP1 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 NUP50 TSEN54 NUP54 CLP1 RPP38 PROGRESSIVE TRIMMING OF ALPHA-1,2-LINKED MANNOSE RESIDUES FROM MAN9 8 7GLCNAC2 TO PRODUCE MAN5GLCNAC2%REACTOME%R-HSA-964827.2 Progressive trimming of alpha-1,2-linked mannose residues from Man9 8 7GlcNAc2 to produce Man5GlcNAc2 MAN1C1 MAN1A2 MAN1A1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF UNSATURATED FATTY ACIDS%REACTOME%R-HSA-77288.2 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids HADHB HADHA ACADL DECR1 ACADM ECI1 NOSTRIN MEDIATED ENOS TRAFFICKING%REACTOME DATABASE ID RELEASE 76%203641 NOSTRIN mediated eNOS trafficking DNM2 CAV1 WASL NOS3 NOSTRIN MATURATION OF PROTEIN E%REACTOME DATABASE ID RELEASE 76%9694493 Maturation of protein E UBB UBA52 UBC RPS27A E DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH3%REACTOME DATABASE ID RELEASE 76%5632927 Defective Mismatch Repair Associated With MSH3 MSH3 MSH2 SELENOCYSTEINE SYNTHESIS%REACTOME%R-HSA-2408557.2 Selenocysteine synthesis RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 SEPHS2 EEFSEC RPS17 RPS16 RPL18A RPS19 RPS18 SECISBP2 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 SEPSECS RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 PSTK RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 SARS1 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 DEFECTIVE DPM1 CAUSES DPM1-CDG (CDG-1E)%REACTOME%R-HSA-4717374.1 Defective DPM1 causes DPM1-CDG (CDG-1e) DPM1 DPM2 DPM3 TOLL LIKE RECEPTOR 5 (TLR5) CASCADE%REACTOME%R-HSA-168176.1 Toll Like Receptor 5 (TLR5) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 NFKBIB fliC TLR10 FBXW11 IRAK4 TLR5 SAA1 MYD88 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN WNT SIGNALING%REACTOME%R-HSA-8939256.1 RUNX1 regulates transcription of genes involved in WNT signaling CBFB AXIN1 RUNX1 ESR1 FOXP3 RSPO3 PERVASIVE DEVELOPMENTAL DISORDERS%REACTOME DATABASE ID RELEASE 76%9005895 Pervasive developmental disorders NCOR1 HDAC3 CAMK4 HDAC1 PRKACA GPS2 CALM1 TBL1XR1 NCOR2 SIN3A TBL1X MIRO GTPASE CYCLE%REACTOME%R-HSA-9715370.1 Miro GTPase Cycle RHOT2 TRAK1 TRAK2 RAP1GDS1 MFN1 MFN2 MYO19 RHOT1 VARIANT SLC6A14 MAY CONFER SUSCEPTIBILITY TOWARDS OBESITY%REACTOME%R-HSA-5619094.1 Variant SLC6A14 may confer susceptibility towards obesity SLC6A14 DISEASES OF CARBOHYDRATE METABOLISM%REACTOME DATABASE ID RELEASE 76%5663084 Diseases of carbohydrate metabolism KHK NAGLU ARSB ALDOB NHLRC1 GNS UBA52 SGSH IDS GUSB IDUA SI LCT GYS1 GYG1 HGSNAT GAA UBB UBC GBE1 RPS27A GYG2 GALNS SLC37A4 EPM2A G6PC3 GYS2 TALDO1 HYAL1 G6PC1 RPIA DCXR PPP1R3C GLB1 DEFECTIVE CYP17A1 CAUSES AH5%REACTOME%R-HSA-5579028.4 Defective CYP17A1 causes AH5 CYP17A1 SYNTHESIS OF PA%REACTOME DATABASE ID RELEASE 76%1483166 Synthesis of PA PLA2G4A GNPAT PLA2G2A PLD6 ALPI AGPAT5 PLA2G1B PLA2G5 PLD1 LCLAT1 AGPAT4 GPAT4 LIPI LIPH AGPAT1 ACP6 GPAT3 PLA2G2F AGPAT2 PLA2G2D PLA2G12A PLA2G4D PLA2G2E MIGA2 PLA2G4B MIGA1 DDHD2 GPAT2 DDHD1 LPCAT4 GPD1 PLA2G10 GPD1L PLA2R1 PLD2 LPCAT1 GPAM GPD2 AGPAT3 MYD88 DEFICIENCY (TLR5)%REACTOME%R-HSA-5602680.1 MyD88 deficiency (TLR5) TLR5 MYD88 fliC SPHINGOLIPID METABOLISM%REACTOME%R-HSA-428157.4 Sphingolipid metabolism ARSA ARSB OSBP VAPB NEU2 NEU3 NEU1 ORMDL3 CTSA GLTP CERK GBA3 GBA2 SPTLC1 SMPD4 SPHK1 STS SPTLC2 SPTLC3 SMPD3 SMPD1 SMPD2 ENPP7 GLB1 CERS3 CERS4 CERS5 CERS6 SPHK2 ASAH1 SPNS2 GBA SUMF2 SUMF1 PRKD3 CPTP PRKD2 PRKD1 PLPP3 PLPP2 CERS1 PLPP1 ALDH3B1 CSNK1G2 CERS2 ASAH2 SAMD8 SGMS1 PPM1L SGMS2 DEGS1 UGCG UGT8 ALDH3B2 SGPL1 ARSL ORMDL2 GLB1L ARSJ ARSK ARSH ESYT1 ARSI SPTSSB B4GALNT1 ARSF SPTSSA ARSG KDSR ARSD B3GALNT1 ORMDL1 SGPP2 GM2A SGPP1 GALC ACER2 ACER1 FA2H ACER3 GLA ESYT3 ESYT2 DEGS2 PSAP HEXB VAPA HEXA AUF1 (HNRNP D0) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 76%450408 AUF1 (hnRNP D0) binds and destabilizes mRNA HSPA8 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 HSPB1 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PABPC1 PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 EIF4G1 HSPA1A TNFR1-INDUCED PROAPOPTOTIC SIGNALING%REACTOME%R-HSA-5357786.2 TNFR1-induced proapoptotic signaling TNFRSF1A TNFAIP3 CASP8 TRADD RIPK1 TRAF2 FADD CYLD OTUD7B TNF UL36 USP21 USP4 USP2 EXTRACELLULAR MATRIX ORGANIZATION%REACTOME%R-HSA-1474244.2 Extracellular matrix organization TNXB COL5A3 JAM2 COL7A1 JAM3 COL6A2 FN1 DSPP COL4A3 PLOD3 COL5A2 PLOD2 COL6A1 PLOD1 COL20A1 ACTN1 COL8A2 COMP IBSP COL4A6 TNN COL4A5 COL21A1 TNR COL8A1 ADAM19 ADAM12 TRAPPC4 COL6A3 PPIB COL6A6 NID2 COL6A5 CRTAP ITGB1 P4HA1 P4HA2 P4HA3 ITGA11 COLGALT2 LAMC3 ADAMTS14 ITGAE HAPLN1 ITGB7 COLGALT1 ITGA3 ASPN ITGAD ITGA7 PCOLCE2 LAMA4 PDGFB LRP4 BMP2 ITGA2B PRSS1 COL16A1 ADAMTS2 COL12A1 ADAMTS3 CAPN15 CAPN8 CAPN9 CAPN6 CAPNS1 ITGAM CAPN7 ITGB2 CAPNS2 CDH1 CAPN5 ITGA10 BSG CAPN2 ITGAX CAPN3 CAPN1 PRSS2 ITGB3 CAST VTN PHYKPL ITGAL CTRB2 ITGAV CTRB1 COL23A1 ITGA2 ADAM10 ITGA1 HSPG2 BCAN ITGA5 ADAM17 ADAM15 ITGA4 ITGA9 OPTC ADAM9 NTN4 ADAM8 COL17A1 COL13A1 SERPINE1 HTRA1 KLK2 PSEN1 NID1 KLK7 ADAMTS16 DAG1 SCUBE3 NCSTN SCUBE1 ADAMTS18 A2M ELANE BMP1 COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 LAMC2 DMD LAMC1 CTSS MMP20 ADAMTS4 ADAMTS5 MMP25 MMP24 CASK ADAMTS1 CTSL CASP3 CTSK TIMP2 CTSG TIMP1 ADAMTS8 TPSAB1 ADAMTS9 CTSD CTSB MMP7 TTR CEACAM1 MMP1 COL25A1 CEACAM6 MMP2 MMP3 CEACAM8 MMP8 CD47 MMP9 DCN MMP10 MMP12 MMP11 MMP14 MMP13 MMP16 MMP15 MMP17 MMP19 CD44 LAMA5 COL15A1 TMPRSS6 LAMA3 FURIN PLG COL19A1 ACAN SPOCK3 SPP1 TNC DMP1 COL26A1 LAMB3 CMA1 LAMB1 CAPN13 CAPN14 FGB CAPN11 FGA CAPN12 CAPN10 TLL2 TLL1 KLKB1 FGG LTBP1 LAMA2 LAMA1 BMP4 FBN1 NCAM1 P4HB FGF2 MATN3 LAMB2 PECAM1 THBS1 NRXN1 PRKCA KDR ICAM2 ICAM3 FBN2 FBN3 BMP10 ELN LTBP4 LTBP2 SDC4 FBLN1 SDC2 LTBP3 FBLN2 SDC3 FBLN5 EFEMP2 SH3PXD2A EFEMP1 ITGB8 ITGB6 TGFB2 TGFB3 BMP7 GDF5 PTPRS MFAP5 MFAP4 MFAP1 MFAP3 MFAP2 ITGA8 LUM SDC1 FMOD AGRN NCAN BGN VCAN ICAM1 ITGB4 LOXL3 LOXL4 LOXL1 LOXL2 PCOLCE LOX PXDN COL11A1 ITGA6 COL11A2 PLEC SPARC COL10A1 CD151 TGFB1 ICAM4 COL28A1 VCAM1 ICAM5 COL27A1 MUSK COL24A1 F11R P3H2 COL22A1 P3H1 COL1A1 P3H3 COL3A1 PDGFA COL2A1 SERPINH1 COL1A2 DDR1 COL5A1 MATN1 COL4A2 MATN4 COL4A1 ITGB5 DDR2 COL4A4 LYSOSOME VESICLE BIOGENESIS%REACTOME DATABASE ID RELEASE 76%432720 Lysosome Vesicle Biogenesis AP1S2 AP1M2 AP1S1 AP1M1 TXNDC5 CLVS2 AP1S3 VAMP8 VAMP7 CLVS1 AP4B1 VAMP2 GNS M6PR CHMP2A APP BLOC1S1 DNM2 ARRB1 CTSZ AP4E1 SH3GL2 AP4M1 HSPA8 HGS AP1G2 AP1G1 ARF1 CLTA CLTC DNASE2 CLTB AP1B1 DNAJC6 AP4S1 ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS%REACTOME DATABASE ID RELEASE 76%176187 Activation of ATR in response to replication stress MCM10 CDC25C CLSPN DBF4 CDK2 ATRIP CDC45 RAD17 CDC7 RAD9B ATR RAD9A MCM7 MCM8 MCM3 MCM4 MCM5 RFC5 MCM6 MCM2 ORC5 ORC4 RFC3 ORC6 RFC4 ORC1 RFC2 ORC3 ORC2 CDC6 RPA1 CHEK1 RPA2 CDC25A RPA3 HUS1 RAD1 RUNX3 REGULATES P14-ARF%REACTOME DATABASE ID RELEASE 76%8951936 RUNX3 regulates p14-ARF CBFB TGFB1 RUNX1 BRD2 EP300 CCND1 RUNX3 HDAC4 KRAS RHO GTPASES ACTIVATE ROCKS%REACTOME DATABASE ID RELEASE 76%5627117 RHO GTPases Activate ROCKs LIMK2 LIMK1 MYL6 MYH14 MYH11 MYL9 MYH10 PPP1CB MYH9 ROCK1 ROCK2 RHOC MYL12B RHOB PAK1 RHOA PPP1R12A CFL1 PPP1R12B GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN GG-NER%REACTOME DATABASE ID RELEASE 76%5696397 Gap-filling DNA repair synthesis and ligation in GG-NER POLD2 XRCC1 POLE4 POLE2 POLE3 PCNA UBA52 UBB RFC5 UBC RFC3 POLK RFC4 RFC2 RPS27A POLE LIG1 RFC1 LIG3 RPA1 RPA2 RPA3 POLD3 POLD4 POLD1 TOLL LIKE RECEPTOR 4 (TLR4) CASCADE%REACTOME%R-HSA-166016.2 Toll Like Receptor 4 (TLR4) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 CASP8 RIPK1 FADD PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DNM1 DNM2 PPP2CA CD180 PPP2CB LY86 DNM3 LBP PTPN11 PPP2R1A BTRC RIPK3 NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN ITGAM ITGB2 RPS27A CREB1 MAPK14 MAPK11 ATF2 FOS S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 TANK PELI1 UBE2D2 UBE2D3 TBK1 IKBKE UBE2D1 IRF3 TRAF3 SOCS1 IRAK4 SAA1 MYD88 TICAM2 LY96 FGB FGA TICAM1 CD14 TLR4 IRF7 FGG BIRC2 BIRC3 PTPN4 ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 BPI S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N PLCG2 TAB3 MAP3K7 TAB2 CARDIAC CONDUCTION%REACTOME DATABASE ID RELEASE 76%5576891 Cardiac conduction ATP2A1 SLC8A1 SLC8A2 NOS1 FKBP1B KCNJ11 ATP1B3 STIM1 ATP1B2 ATP1B1 ORAI2 ORAI1 CACNA2D2 ITPR1 ITPR2 ITPR3 SRI CACNG8 ATP2B4 ATP2B3 CACNG4 ATP2B2 FXYD4 ATP2B1 FXYD3 FXYD2 FXYD1 SLC8A3 FXYD7 FXYD6 PRKACA HIPK1 SCN11A GATA4 CALM1 TRDN SCN10A ATP1A4 ATP1A3 ATP1A2 ATP1A1 KCNK18 AKAP9 SLN CACNB1 CACNB2 CAMK2B CAMK2D CAMK2A CAMK2G HIPK2 KCNK12 KCNK15 KCNE1 KCNE2 KCNE3 KCNE4 KCNE5 DMPK FGF14 FGF13 FGF12 FGF11 KCNK5 WWTR1 SCN1B SCN1A CACNG6 CACNG7 TRPC1 ASPH TNNI3 KCNIP1 KCNIP2 KCNIP3 KCNIP4 SCN3B KCNH2 SCN3A RANGRF PLN KCNK10 SCN2A SCN2B KCNK13 KCNK16 KCNK17 KCNQ1 KCNK6 KCNK7 KCNK9 SCN9A KCND1 KAT2B KCND2 KCND3 SCN8A CACNA1C KCNJ2 KCNJ4 KCNJ12 KCNJ14 SCN5A SCN4A KCNK1 SCN4B KCNK2 KCNK3 KCNK4 SCN7A AHCYL1 RYR1 RYR2 NPPC NPR1 RYR3 NPR2 NPPA CLIC2 TBX5 NKX2-5 CORIN ABCC9 ATP2A3 ATP2A2 OREXIN AND NEUROPEPTIDES FF AND QRFP BIND TO THEIR RESPECTIVE RECEPTORS%REACTOME%R-HSA-389397.1 Orexin and neuropeptides FF and QRFP bind to their respective receptors QRFP HCRTR2 NPFFR2 HCRTR1 NPFFR1 QRFPR HCRT NPFF IRF3-MEDIATED INDUCTION OF TYPE I IFN%REACTOME%R-HSA-3270619.1 IRF3-mediated induction of type I IFN DDX41 TBK1 PRKDC NLRC3 MRE11 IFI16 XRCC6 XRCC5 TREX1 IRF3 STING1 NLRP4 DTX4 CHL1 INTERACTIONS%REACTOME%R-HSA-447041.1 CHL1 interactions NRP1 ITGA2 ITGA1 HSPA8 CNTN6 ANK1 CHL1 ITGA10 ITGB1 MRNA EDITING%REACTOME%R-HSA-75072.3 mRNA Editing ADAR ADARB1 APOBEC1 APOBEC3C APOBEC2 APOBEC4 APOBEC3H A1CF APOBEC3A APOBEC3B NUCLEAR ENVELOPE (NE) REASSEMBLY%REACTOME%R-HSA-2995410.5 Nuclear Envelope (NE) Reassembly TUBB6 TUBB3 TUBB1 NUP43 VRK1 SUMO1 RAN NUP35 CHMP2B NUP37 ANKLE2 CHMP2A TUBA4B PPP2CA LBR EMD KPNB1 RCC1 CHMP3 TUBA1A SEC13 PPP2R1A TUBA8 LEMD3 CHMP6 TUBA1C CHMP7 TUBA1B NUP107 NUP188 TUBB2B TUBB2A PPP2R2A SIRT2 VPS4A TUBAL3 BANF1 TUBB8 TUBA3E SPAST TUBB8B LEMD2 NUP93 TUBA3D CC2D1B POM121 TUBA3C TUBA4A NUP205 IST1 NUP160 NUP85 NUP155 RANGAP1 TNPO1 CCNB2 CCNB1 LMNB1 CHMP4C CHMP4B CHMP4A NUP62 NDC1 TUBB4B TUBB4A NUP133 AHCTF1 CDK1 NUP54 UBE2I PHOSPHOLIPID METABOLISM%REACTOME%R-HSA-1483257.3 Phospholipid metabolism RAB4A GNPAT SYNJ2 PLD6 AGK SYNJ1 PIK3C2A RAB5A LPGAT1 TAZ PITPNB CPNE7 CPNE6 OCRL MFSD2A STARD7 RUFY1 PLA1A MTMR8 PLA2G3 MTMR9 LPCAT1 MTMR6 MTMR7 PGS1 PTDSS2 PTDSS1 PTPMT1 PIK3R2 INPP5J INPP5K TMEM86B STARD10 PEMT CDS2 DGAT2L7P OSBPL10 TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 RAB14 PLEKHA8 LPCAT3 LPCAT2 PNPLA3 TPTE2 ABHD4 ABHD3 PLD4 PLD3 OSBPL8 OSBPL5 HADHB DGAT2L6 HADHA CRLS1 PI4KB TNFAIP8 PIK3C2G PIK3C2B TPTE AWAT2 MBOAT7 MBOAT1 MBOAT2 CHPT1 PIK3CD INPP5E CPNE1 CPNE3 PLB1 AGPAT1 PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLBD1 GPCPD1 VAC14 MTMR10 MTMR12 MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A INPP5D SBF1 SBF2 PIK3R4 PIK3CB AGPAT2 MTMR3 MTMR14 PIP4K2A PIP4K2B PIP4K2C PNPLA2 PIK3C3 CHKB PCYT2 CHKA SELENOI PISD ETNPPL PHOSPHO1 ETNK2 ETNK1 CEPT1 PLA2G4A CSNK2A1 PLA2G2A CSNK2A2 CSNK2B ALPI PIP4P1 PLD1 INPPL1 MTMR4 PIK3R1 AGPAT3 CHAT PIP5K1A PIP5K1B PCTP PTPN13 GPAT2 DGAT2 DGAT1 GPAM GPD2 LPIN1 LPIN2 LPIN3 MGLL SLC44A1 PIK3CA PLA2G6 PIP5K1C AGPAT5 PLA2G1B PLA2G5 LCLAT1 AGPAT4 GPAT4 LIPI LIPH ACP6 GPAT3 PLA2G2F CDS1 PLA2G2D ARF3 PITPNM1 PLA2G12A PIK3R6 PITPNM3 PLA2G2E PITPNM2 MIGA2 PIK3CG PIK3R5 MIGA1 CDIPT ARF1 DDHD2 DDHD1 LPCAT4 ACHE GPD1 BCHE PLA2G10 PI4K2B GPD1L MTMR2 PLA2R1 SACM1L PI4KA PTEN SLC44A5 SLC44A3 SLC44A4 SLC44A2 PIK3R3 BMX PLD2 PNPLA7 GDE1 GDPD1 GDPD3 PNPLA6 ENPP6 GDPD5 MTMR1 UNCOATING OF THE INFLUENZA VIRION%REACTOME%R-HSA-168336.3 Uncoating of the Influenza Virion PA PB2 NP NA NS HA M PB1 SIGNALING BY AMER1 MUTANTS%REACTOME DATABASE ID RELEASE 76%4839748 Signaling by AMER1 mutants PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH3 (MUTSBETA)%REACTOME%R-HSA-5358606.1 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) POLD2 MSH3 MSH2 LIG1 PCNA RPA1 RPA2 PMS2 MLH1 RPA3 POLD3 POLD4 EXO1 POLD1 CA-DEPENDENT EVENTS%REACTOME DATABASE ID RELEASE 76%111996 Ca-dependent events PRKCG KPNA2 PRKACG PRKACB PLA2G4A ADCY9 CAMKK1 PRKAR1B CAMKK2 PRKAR1A MAPK1 PDE1B PDE1A PRKAR2A PRKX PRKCD PRKCA CAMK2B PRKAR2B CAMK2D NBEA CAMK2A PDE1C CAMK2G ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 CAMK4 ADCY6 ADCY5 PRKACA GRK2 CALM1 DEACTIVATION OF THE BETA-CATENIN TRANSACTIVATING COMPLEX%REACTOME%R-HSA-3769402.3 Deactivation of the beta-catenin transactivating complex HDAC1 TCF7L2 TCF7L1 MEN1 SRY CTNNB1 CTBP1 UBA52 XIAP RBBP5 AKT2 TLE4 TLE3 KMT2D XPO1 TLE2 TLE1 ASH2L AKT1 UBB APC YWHAZ UBC SOX2 RPS27A SOX9 CHD8 CBY1 SOX3 SOX17 SOX6 SOX7 SOX4 BTRC BCL9L CTNNBIP1 SOX13 PYGO1 PYGO2 BCL9 TCF7 LEF1 PRE-NOTCH EXPRESSION AND PROCESSING%REACTOME DATABASE ID RELEASE 76%1912422 Pre-NOTCH Expression and Processing ATP2A1 CREBBP TP53 RUNX1 ST3GAL3 SNW1 MAMLD1 AGO3 AGO4 AGO1 AGO2 H2AX PRKCI H2AB1 H2AC19 ST3GAL4 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 TMED2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 ST3GAL6 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 FURIN H2BC11 H3C15 POGLUT1 H2BS1 POFUT1 SEL1L H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 NOTCH2 H2BC5 LFNG NOTCH3 H2BC3 NOTCH4 H2BC1 H2AC20 TFDP1 JUN TFDP2 CCND1 E2F1 E2F3 MAML2 TNRC6C MAML1 MOV10 RBPJ TNRC6A TNRC6B B4GALT1 SIRT6 MAML3 ELF3 MFNG NOTCH1 RFNG ATP2A3 RAB6A ATP2A2 DASATINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669914.1 Dasatinib-resistant KIT mutants KIT SPHINGOLIPID DE NOVO BIOSYNTHESIS%REACTOME%R-HSA-1660661.7 Sphingolipid de novo biosynthesis CERS4 CERS5 CERS6 SPHK2 SPNS2 PRKD3 PRKD2 PRKD1 PLPP3 PLPP2 CERS1 ALDH3B1 PLPP1 CSNK1G2 CERS2 SAMD8 SGMS1 PPM1L SGMS2 DEGS1 ALDH3B2 SGPL1 ORMDL2 OSBP SPTSSB SPTSSA KDSR VAPB ORMDL1 SGPP2 SGPP1 ACER2 ACER1 FA2H ACER3 ORMDL3 DEGS2 SPTLC1 VAPA SPHK1 SPTLC2 SPTLC3 CERS3 TRANSLATION%REACTOME%R-HSA-72766.4 Translation IARS1 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 EIF2S2 MRPL3 EIF2S1 MRPL2 EIF2S3 MRPL1 MRPL40 MRPL9 CHCHD1 RPL4 MRPS28 RPL5 TSFM RPL30 MRPS26 RPL3 MRPS27 RPL32 MRPS24 RPL31 MRPS25 RPL34 MRPS22 RPLP1 MRPS23 MRPS18B RPL10L RPLP0 MRPL49 MRPS18A RPL10A RPL8 MRPS2 RPL6 MRPS21 RPL7 MRPL47 MRPL48 RPS4X RPS15 MRPL45 MRPS7 RPL7A RPS14 MRPL46 RPS17 MRPS6 RPS16 MRPL43 RPL18A MRPS5 RPS19 MRPL44 RPS18 TUFM RPL36AL MRPS18C RPL36 MRPL52 RPL35 MRPL53 RPLP2 OXA1L RPL38 UBA52 MRPS9 RPL37 MRPL50 RPS11 MRPL51 RPL39 AURKAIP1 RPS10 DAP3 RPS13 MRPS35 RPS12 MRPS36 MRPL18 MRPS33 RPS9 MRPS34 RPS7 RPL21 MRPL19 MRPL16 MRPS31 RPS8 MRPL17 MRPL58 RPS5 RPL23 MRPL14 RPL22 MRPL15 MRPS30 RPS6 MRPL12 RPL13A MRPL57 RPSA MRPL13 RPS3A MRPL10 RPS27A RPL9P9 MRPL54 RPL37A RPL24 MRPL55 RPL27 MRPL11 MRPL20 ETF1 RPL26 PTCD3 RPL29 GADD45GIP1 RPL28 MRPL27 RPS4Y2 MRPL28 ERAL1 RPL10 MRPL23 RPL12 MRPL24 RPL11 MRPL21 RPL36A MRPL22 RPS27L RPS4Y1 MRPL30 GSPT2 GSPT1 RPS15A RPL14 RPS3 RPL13 RPS2 PARS2 RPL15 EARS2 RPL18 LARS2 RPL17 PPA2 RPL19 TARS2 RPL39L AARS2 RPL41 HARS2 RPL35A EIF5 RPL23A RPL3L TRAM1 RPS26 GFM2 RPS25 SRP54 RPS28 FARS2 RPS27 SSR4 RPS29 SSR2 RPL27A SSR3 SRP9 RPL22L1 RPS20 MRRF SRP72 FAU RPS21 SRP68 SPCS3 SPCS2 SRP19 RPL26L1 RPS24 SPCS1 MTFMT RPS23 YARS2 NARS2 SEC11A RARS2 SEC11C CARS2 VARS2 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF5B MARS2 DARS2 SARS2 MTRF1L MTIF2 MTIF3 EIF4H IARS2 WARS2 N6AMT1 APEH TRMT112 SRP14 EEF1B2 EEF1A1 EEF1G EEF1D EEF1A2 EEF1A1P5 EEF2 SEC61A2 SEC61A1 SEC61G SEC61B RPN2 RPN1 DDOST LARS1 PABPC1 AIMP1 AIMP2 EIF4G1 EPRS1 AARS1 QARS1 HARS1 YARS1 WARS1 GARS1 NARS1 PPA1 FARSA CARS1 TARS1 FARSB EEF1E1 VARS1 SSR1 KARS1 SRPRA SRPRB RARS1 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 EIF4A1 EIF4EBP1 EIF4E EIF4B MARS1 DARS1 SARS1 REPLICATION OF THE SARS-COV-1 GENOME%REACTOME DATABASE ID RELEASE 76%9682706 Replication of the SARS-CoV-1 genome GSK3B RB1 ZCRB1 DDX5 VHL N GSK3A 1a rep FCERI MEDIATED MAPK ACTIVATION%REACTOME DATABASE ID RELEASE 76%2871796 FCERI mediated MAPK activation V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV GRAP2 V5-4 V5-1 SYK VAV3 V5-6 MAPK1 VAV1 IGLV3-19 MAPK3 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 VAV2 IGLV PAK1 V3-4 MAPK8 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 JUN IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 PLCG1 IGHE SOS1 FOS LCP2 IGHV3-23 IGLV2-8 MAP2K4 IGKV1-16 MAP2K7 HRAS IGKV1-17 PAK2 IGKV1-12 IGHV3-7 IGHV3-9 MAPK9 IGHV3-30 MAP3K1 V2-17 MAPK10 IGHV3-33 NRAS V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 PLCG2 ACTIVATION OF PKB%REACTOME%R-HSA-165158.4 Activation of PKB THEM4 TRIB3 PDPK1 AKT2 ASPARTATE AND ASPARAGINE METABOLISM%REACTOME%R-HSA-8963693.1 Aspartate and asparagine metabolism FOLH1B ASPG SLC25A12 NAT8L NAALAD2 ASPA SLC25A13 GOT1 GADL1 FOLH1 GOT2 ASNS CHROMOSOME MAINTENANCE%REACTOME DATABASE ID RELEASE 76%73886 Chromosome Maintenance BLM NOP10 ANKRD28 RFC5 RFC3 RFC4 PPP6C RFC2 CENPA CENPC PPP6R3 ACD TINF2 WRN CENPT TERF1 CENPU TERF2 WRAP53 CENPH RPA1 H3-4 CENPI POT1 RPA2 TERF2IP CENPK CENPL CENPM RPA3 CENPN CENPO CENPP CENPQ CENPS RTEL1 RUVBL1 DAXX LIG1 ATRX RFC1 KNL1 POLD3 POLD4 CCNA2 POLD1 CCNA1 POLD2 CDK2 PRIM2 PRIM1 POLA1 POLA2 PCNA POLR2A POLR2B POLR2C POLR2D NPM1 POLR2E POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L H2AC14 H2BC21 DSCC1 H2BU1 HJURP H3-3B RUVBL2 OIP5 H2AC8 SHQ1 H2AC6 PIF1 H2AC7 CHTF8 TERT CTC1 H2BC17 RSF1 H2BC12 CHTF18 H2BC13 MIS18BP1 H2BC14 STN1 H2AJ CENPW CENPX H2BC15 TEN1 MIS18A H2BC11 RBBP4 H2BS1 RBBP7 H2AZ1 H2BC9 ITGB3BP H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 H2AC20 DKC1 NHP2 GAR1 FEN1 DNA2 RHOB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013026 RHOB GTPase cycle STARD8 CAVIN1 DIAPH1 DLC1 DAAM1 TJP2 IQGAP3 RTKN TFRC ARHGDIG STARD13 JUP MCF2L SNAP23 RHOB ARHGAP1 ARHGAP39 ARHGAP5 FLOT1 ARHGAP35 ARHGEF5 ARHGEF25 PREX1 CIT OPHN1 RHPN2 PKN3 ERBIN MYO9B ECT2 VAV2 PIK3R1 BCR VAMP3 NET1 PKN2 ARHGEF10L PIK3R2 ACTC1 PKN1 AKAP13 ARHGAP21 ABR ARHGEF11 ARHGEF10 RACGAP1 STK10 ARHGEF12 MYO9A SLK VANGL1 ARHGEF17 DEPDC1B ARHGEF3 ROCK1 ARHGEF1 ROCK2 ARHGEF2 CAV1 MCAM STOM MCF2 ARHGAP26 ARHGAP32 DIAPH3 ARHGEF28 FLOT2 PCDH7 ANLN SOWAHC DEFECTIVE CSF2RB CAUSES SMDP5%REACTOME DATABASE ID RELEASE 76%5688849 Defective CSF2RB causes SMDP5 SFTPA2 SFTPA1 SFTPC CSF2RB SFTPB SFTPD CSF2RA SFTA3 REGULATION OF CORTICAL DENDRITE BRANCHING%REACTOME%R-HSA-8985801.1 Regulation of cortical dendrite branching ROBO2 ROBO1 NCK2 SLIT1 UNBLOCKING OF NMDA RECEPTORS, GLUTAMATE BINDING AND ACTIVATION%REACTOME%R-HSA-438066.3 Unblocking of NMDA receptors, glutamate binding and activation GRIA3 GRIA4 GRIN2C CAMK2B CAMK2D CAMK2A CAMK2G ACTN2 GRIA1 GRIN2B GRIN1 GRIN2D GRIA2 DLG1 DLG2 CALM1 DLG3 LRRC7 DLG4 NEFL GRIN2A TRANSCRIPTIONAL REGULATION BY VENTX%REACTOME DATABASE ID RELEASE 76%8853884 Transcriptional Regulation by VENTX TP53 TCF7L2 CDKN2A CTNNB1 AGO3 AGO4 AGO1 EHMT2 IL6 CSF1R FZR1 RELA CCND1 TNRC6C ANAPC15 MOV10 CEBPB ANAPC16 ANAPC7 UBE2C EHMT1 UBE2E1 TNRC6A UBE2D1 TNRC6B ANAPC10 VENTX ANAPC11 CDC23 UBE2S CDC26 NFKB1 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 LEF1 SYNTHESIS OF DIPHTHAMIDE-EEF2%REACTOME%R-HSA-5358493.1 Synthesis of diphthamide-EEF2 EEF2 DPH1 DPH2 DPH3 DPH5 DNAJC24 DPH6 DPH7 HOST INTERACTIONS OF HIV FACTORS%REACTOME%R-HSA-162909.1 Host Interactions of HIV factors AP1M2 AP1M1 NUP42 rev NUP43 gag-pol RAE1 vif RANBP2 vpr vpu RAN NUP35 NUP37 FYN ATP6V1H HCK KPNA1 CD4 KPNB1 AP1G1 BTRC SKP1 SLC25A5 UBA52 SLC25A4 SLC25A6 XPO1 RANGAP1 NUP214 UBB UBC RPS27A RAC1 AP1B1 AP1S2 CCNT1 AP1S1 AP1S3 DOCK2 ELOB ELOC nef B2M HLA-A CD8B tat LCK RBX1 PACS1 CD28 CDK9 NPM1 HMGA1 RCC1 ARF1 SEC13 AP2A1 AP2A2 NUP107 NUP188 AP2M1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 BANF1 PSMD3 NUP210 ELMO1 PSMD1 PSMA5 NUP93 PSMA6 PPIA PSMA3 POM121 PSIP1 PSMA4 NUP205 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 AAAS PSMB11 PSMD12 PSMD11 NUP160 AP2S1 PSMD14 POM121C PSMD13 NUP85 TPR NUP88 PSMA7 PSMB10 NUP155 PSMA8 PSMB6 PSMB7 NUP153 PSMB4 PSMB5 PSMB2 AP2B1 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CUL5 PSMC4 PSMC1 PSMC2 NUP62 gag NDC1 NUP133 RANBP1 NUP50 NUP54 GLYCOPROTEIN HORMONES%REACTOME DATABASE ID RELEASE 76%209822 Glycoprotein hormones CGB8 INHBB INHBA INHBC INHBE LHB TSHB INHA CGA FSHB DISINHIBITION OF SNARE FORMATION%REACTOME%R-HSA-114516.4 Disinhibition of SNARE formation STX4 PRKCA PRKCB PRKCG STXBP3 P75NTR RECRUITS SIGNALLING COMPLEXES%REACTOME DATABASE ID RELEASE 76%209543 p75NTR recruits signalling complexes UBB NGF IKBKB MYD88 UBC SQSTM1 RPS27A UBA52 IRAK1 RIPK2 TRAF6 PRKCI NGFR BIOSYNTHESIS OF E-SERIES 18(S)-RESOLVINS%REACTOME%R-HSA-9018896.1 Biosynthesis of E-series 18(S)-resolvins ALOX5 LTA4H ALOX15 HPGD REPRESSION OF WNT TARGET GENES%REACTOME%R-HSA-4641265.3 Repression of WNT target genes HDAC1 TCF7L2 TCF7L1 TLE4 TLE3 TLE2 TLE1 CTBP2 CTBP1 TLE5 TCF7 LEF1 PYRIMIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 76%73621 Pyrimidine catabolism DPYD TYMP NT5C UPP2 NT5M NT5E UPP1 AGXT2 DPYS UPB1 NT5C1A DEFECTIVE CYP27A1 CAUSES CTX%REACTOME%R-HSA-5578996.4 Defective CYP27A1 causes CTX CYP27A1 INITIAL TRIGGERING OF COMPLEMENT%REACTOME%R-HSA-166663.2 Initial triggering of complement V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 C3 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 FCN1 FCN2 IGHV4-34 FCN3 IGHV1-2 IGHV4-39 C4A IGKV2-29 MASP1 IGKV2-28 IGLC3 IGLC1 IGLC2 C4B_2 V1-9 C2 V1-7 V1-5 V1-3 IGKV3D-20 MBL2 IGKV2-30 IGHV2-70 IGHV2-5 C1QB IGHV3-48 CRP IGLV3-1 C1QA COLEC11 COLEC10 IGKV1-39 C1S IGKV1-33 C1R IGHV3-53 IGLC7 IGKV5-2 IGLC6 C1QC IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 CFD IGKV4-1 GZMM IGHV7-81 CFB V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-1592230.2 Mitochondrial biogenesis HDAC3 CREBBP CHCHD3 HCFC1 RXRA MEF2D PPARGC1A PPARA NR1D1 HSPA9 ATP5MC1 MEF2C PRKAB2 PPARGC1B PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 SIRT3 ESRRA CALM1 TFB1M CYCS ALAS1 MICOS13 MICOS10 MT-ATP6 CHCHD6 MTERF1 GABPA ATP5F1A TWNK ATP5F1B SIRT4 SIRT5 PPRC1 POLG2 PERM1 ATP5MC2 MTX2 ATP5MC3 TFAM NRF1 TFB2M APOO POLRMT ATP5MG ATP5MF ATP5ME DMAC2L ATP5PF ATP5PD APOOL ATP5PB IDH2 DNAJC11 IMMT ATP5F1C ATP5F1D ATP5F1E MT-ATP8 MAPK12 TMEM11 ATP5PO NCOA1 SSBP1 MED1 NCOA2 SOD2 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X CREB1 NCOR1 CAMK4 GLUD1 MAPK14 SAMM50 MAPK11 MTX1 GLUD2 ATF2 CRTC2 CRTC3 CRTC1 ACSS2 TCF DEPENDENT SIGNALING IN RESPONSE TO WNT%REACTOME DATABASE ID RELEASE 76%201681 TCF dependent signaling in response to WNT CREBBP FZD8 FZD5 FZD6 KREMEN1 KREMEN2 AMER1 RNF43 WNT3A PPP2R1A BTRC LRP5 LRP6 CSNK1E WNT1 WNT4 FZD1 RYK CAV1 DVL1 UBA52 DVL3 ASH2L RSPO3 UBB RUVBL1 UBC RPS27A CHD8 CBY1 SOX3 SOX17 MYC SOX6 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 PYGO1 PYGO2 RUNX3 BCL9 TCF7 LEF1 TCF7L2 TCF7L1 SMURF2 CTNNB1 FRAT1 FRAT2 TLE4 TLE3 TLE2 TLE1 H2AX H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 RNF146 H2AC8 H2AC6 H2AC7 TERT H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 SRY PSMA3 H2BS1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 PSMD10 H2AZ2 H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 XIAP PSMD14 H2BC3 PSMD13 RBBP5 PSMA7 H2BC1 PSMB10 PSMA8 ZNRF3 RSPO2 PSMB6 RSPO1 PSMB7 H2AC20 PSMB4 LGR6 PSMB5 LGR5 PSMB2 LGR4 RSPO4 PSMB3 APC SFRP1 PSMB1 SFRP2 PSMF1 HECW1 CCDC88C PSMB8 SOX2 WIF1 PSMB9 WNT5A KLHL12 SEM1 PSMC5 SOST PSMC6 DACT1 SOX9 PSMC3 CXXC4 PSMC4 PSMC1 PSMC2 KAT5 CDC73 TRRAP PPP2R1B LEO1 PPP2R5E PPP2R5B PPP2R5A PPP2R5D CSNK2A1 PPP2R5C CSNK2A2 CSNK2B PPP2CA PPP2CB H3-4 USP8 MEN1 USP34 GSK3B AXIN1 AXIN2 XPO1 PIP5K1B AKT1 YWHAZ CTBP1 RBX1 WNT9A KMT2D WNT8A WNT8B FZD4 WNT3 CSNK1A1 CSNK1G2 CUL3 AKT2 TNKS2 TNKS DKK1 DKK2 DKK4 DVL2 SMARCA4 IONOTROPIC ACTIVITY OF KAINATE RECEPTORS%REACTOME DATABASE ID RELEASE 76%451306 Ionotropic activity of kainate receptors GRIK4 GRIK1 GRIK2 GRIK3 DLG1 CALM1 NCALD DLG3 DLG4 GRIK5 INHIBITION OF PKR%REACTOME DATABASE ID RELEASE 76%169131 Inhibition of PKR NS EIF2AK2 PLASMA LIPOPROTEIN REMODELING%REACTOME DATABASE ID RELEASE 76%8963899 Plasma lipoprotein remodeling APOA1 APOA4 APOA5 ANGPTL8 ANGPTL3 ANGPTL4 LPA ABCG1 CETP LPL LCAT LMF2 LMF1 APOF APOE FGF21 GPIHBP1 MBTPS1 APOC3 APOC2 ALB APOB MBTPS2 PCSK6 PCSK5 LIPC CREB3L3 LIPG FURIN APOA2 DEFECTIVE SERPING1 CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657689.1 Defective SERPING1 causes hereditary angioedema SERPING1 KLKB1 F12 CALCITONIN-LIKE LIGAND RECEPTORS%REACTOME DATABASE ID RELEASE 76%419812 Calcitonin-like ligand receptors ADM2 IAPP RAMP1 CALCA CALCB CALCRL RAMP2 ADM RAMP3 CALCR HS-GAG DEGRADATION%REACTOME DATABASE ID RELEASE 76%2024096 HS-GAG degradation GPC5 NAGLU GPC4 GPC6 SDC1 AGRN HPSE2 HSPG2 SGSH SDC4 IDS SDC2 GUSB IDUA SDC3 GLB1L HPSE GPC1 GLB1 GPC3 GPC2 DEFECTIVE SLC17A8 CAUSES AUTOSOMAL DOMINANT DEAFNESS 25 (DFNA25)%REACTOME DATABASE ID RELEASE 76%5619076 Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25) SLC17A8 MICRORNA (MIRNA) BIOGENESIS%REACTOME%R-HSA-203927.3 MicroRNA (miRNA) biogenesis POLR2L BCDIN3D RAN XPO5 DROSHA AGO3 PRKRA POLR2A AGO4 POLR2B AGO1 POLR2C AGO2 DICER1 POLR2D POLR2E TARBP2 POLR2F POLR2G POLR2H POLR2I POLR2J DGCR8 POLR2K ABACAVIR TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-2161517.2 Abacavir transmembrane transport SLC22A2 SLC22A1 ABCB1 SLC22A3 ABCG2 DEFECTIVE CYP19A1 CAUSES AEXS%REACTOME%R-HSA-5579030.2 Defective CYP19A1 causes AEXS CYP19A1 GSD IA%REACTOME DATABASE ID RELEASE 76%3274531 GSD Ia G6PC1 PYRUVATE METABOLISM%REACTOME%R-HSA-70268.6 Pyruvate metabolism PDHB VDAC1 DLAT PDHA2 RXRA PDHX SLC16A1 PDHA1 GSTZ1 DLD SLC16A8 SLC16A3 PPARD BSG GLO1 LDHC LDHB LDHA PDPR MPC1 MPC2 PDK4 ME1 PDK3 PDK2 PDK1 PDP1 PDP2 LDHAL6A LDHAL6B DIMERIZATION OF PROCASPASE-8%REACTOME DATABASE ID RELEASE 76%69416 Dimerization of procaspase-8 FADD FASLG FAS CASP8 TRADD TNFSF10 TNFRSF10B RIPK1 TNFRSF10A TRAF2 SIGNALING BY RAS MUTANTS%REACTOME%R-HSA-6802949.2 Signaling by RAS mutants BRAP FN1 BRAF FGB FGA VWF KRAS FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CAMK2B PHB CSK CAMK2D HRAS CAMK2A MARK3 MAP3K11 CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 JAK2 KSR2 CALM1 SRC DEFECTIVE ALG6 CAUSES ALG6-CDG (CDG-1C)%REACTOME DATABASE ID RELEASE 76%4724289 Defective ALG6 causes ALG6-CDG (CDG-1c) ALG6 TRANSCRIPTIONAL REGULATION OF TESTIS DIFFERENTIATION%REACTOME%R-HSA-9690406.2 Transcriptional regulation of testis differentiation PTGDS WT1 DMRT1 DHH GATA4 NR5A1 SRY SOX9 FGF9 AMH INACTIVATION OF CSF3 (G-CSF) SIGNALING%REACTOME DATABASE ID RELEASE 76%9705462 Inactivation of CSF3 (G-CSF) signaling ELOB ELOC SOCS3 TYK2 SYK RNF7 UBA52 STAT3 HCK LYN UBB STAT5A STAT5B STAT1 UBC UBE2D2 UBE2D3 RPS27A CUL5 CSF3R UBE2D1 JAK2 SOCS1 JAK1 CSF3 CHROMATIN MODIFYING ENZYMES%REACTOME DATABASE ID RELEASE 76%3247509 Chromatin modifying enzymes CREBBP PBRM1 ARID2 KDM1A PADI2 DPY30 KMT2A KDM7A HDAC8 PHF21A SETD1B SETD1A RCOR1 ASH2L RUVBL1 CCND1 CDK4 HMG20B ACTL6A JAK2 ATF2 RPS2 MCRS1 YEATS4 CLOCK TAF9 TAF12 TAF10 H2AX EHMT2 H2AB1 H2AC19 CHD4 CHD3 ACTB H2AC14 H2BC21 EP300 H2BU1 H3C8 RUVBL2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 H2BC11 HDAC2 HDAC1 H3C15 MTA1 RBBP4 WDR5 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 SMARCD1 SMARCD2 H2BC3 RBBP5 H2BC1 GATAD2B GATAD2A H2AC20 SMARCE1 NCOA1 NCOA2 SMARCD3 TBL1XR1 CARM1 TBL1X EHMT1 KAT5 PRMT6 KDM6A KMT5A KAT6A KDM3A KAT8 HDAC3 KAT7 TRRAP SUPT20H ATXN7L3 MEAF6 H2AC17 PADI3 H2AC12 PADI4 PADI1 PADI6 SMYD2 PRDM16 KAT14 HCFC1 SETDB1 SETDB2 KDM5B TADA2A ZZZ3 SUV39H2 BRPF1 SETD2 BRPF3 SETD3 TADA2B SETD6 H2AC21 SETD7 SGF29 ARID1A H2AW ING4 ARID1B ING3 PRMT7 PRMT3 PAX3 ASH1L SUPT3H ING5 TAF6L DOT1L NSD3 WDR77 NSD1 BRD8 ELP1 ELP2 PRMT5 ELP3 ELP4 BRD1 ELP5 ELP6 PRDM9 JADE1 JADE3 JADE2 KDM5A PHF2 KMT5B KMT5C KDM5C SUPT7L KDM5D MORF4L1 KDM3B PHF8 KAT6B MORF4L2 UTY KDM2A HAT1 KDM2B ENY2 TAF5L KDM4D ARID5B MBIP JMJD6 DMAP1 KDM1B SMYD3 RIOX2 DR1 COPRS MRGBP NFKB1 YEATS2 TADA1 BRWD1 H2AC1 VPS72 MSL2 MSL3 MSL1 ATF7IP ATXN7 KANSL1 KANSL2 KANSL3 TADA3 OGT ACTL6B ARID4B SAP130 SAP30 SUDS3 EZH2 SUV39H1 H2BC18 EED AEBP2 MECOM SAP30L SAP18 SUZ12 GPS2 USP22 NCOR2 NCOR1 PHF20 PRMT1 EP400 KMT2E KMT2D KMT2C KMT2B KDM6B NSD2 KDM4A KDM4B ARID4A KDM4C BRMS1 REST SMARCB1 EPC1 SMARCC1 SMARCC2 RELA NFKB2 HDAC10 SMARCA2 SMARCA4 AGGREPHAGY%REACTOME%R-HSA-9646399.3 Aggrephagy UBB HSF1 UBE2V1 PRKN HDAC6 HSP90AA1 PARK7 CFTR UBC DYNC1I1 RPS27A PCNT DYNLL1 VCP DYNC1LI1 DYNC1LI2 DYNC1H1 CETN1 IFT88 ARL13B UBA52 DYNC1I2 DYNLL2 UBE2N FICOLINS BIND TO REPETITIVE CARBOHYDRATE STRUCTURES ON THE TARGET CELL SURFACE%REACTOME%R-HSA-2855086.1 Ficolins bind to repetitive carbohydrate structures on the target cell surface FCN1 FCN2 FCN3 MASP1 DEFECTIVE CFTR CAUSES CYSTIC FIBROSIS%REACTOME%R-HSA-5678895.3 Defective CFTR causes cystic fibrosis DERL1 DERL2 CFTR RNF5 ERLEC1 OS9 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 PSME3 PSME4 SEL1L PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 ERLIN1 PSMB4 PSMB5 ERLIN2 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 RNF185 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DERL3 PROTEIN REPAIR%REACTOME DATABASE ID RELEASE 76%5676934 Protein repair MSRA PCMT1 MSRB2 MSRB3 MSRB1 TXN VEGFA-VEGFR2 PATHWAY%REACTOME DATABASE ID RELEASE 76%4420097 VEGFA-VEGFR2 Pathway WASF3 PRKCB MAPKAP1 DOCK1 CTNNA1 PIK3CA PLCG1 CTNNB1 PRKACG PRKACB CYFIP1 NCKAP1 NCF1 JUP NCF2 FYN PRR5 VAV3 PAK3 NCF4 BRK1 VAV1 ITPR1 ELMO2 ITPR2 ITPR3 HSP90AA1 NOS3 PDPK1 CYBB CYBA CTNND1 RICTOR VAV2 PIK3R1 PRKACA SHC2 CDC42 TRIB3 PAK1 NCK2 SPHK1 CALM1 PIK3R2 NCK1 ELMO1 CRK SHB NCKAP1L CDH5 WASF1 SH2D2A PXN PTK2B WASF2 AXL ROCK1 ROCK2 CAV1 BCAR1 BAIAP2 CYFIP2 HSPB1 AKT2 ABI2 MLST8 AHCYL1 ABI1 AKT1 MAPK12 PRKCD MAPK13 PRKCA PTK2 MAPKAPK3 MTOR HRAS KDR MAPKAPK2 PAK2 PIK3CB RASA1 NRAS ITGB3 THEM4 ITGAV RAC1 MAPK14 MAPK11 PRKCZ RHOA AKT3 BICARBONATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%425381 Bicarbonate transporters AHCYL2 SLC4A7 SLC4A8 SLC4A9 SLC4A1 SLC4A10 SLC4A2 SLC4A4 SLC4A3 SLC4A5 DEFECTIVE TRANSLOCATION OF RB1 MUTANTS TO THE NUCLEUS%REACTOME%R-HSA-9661070.1 Defective translocation of RB1 mutants to the nucleus RB1 SLBP INDEPENDENT PROCESSING OF HISTONE PRE-MRNAS%REACTOME%R-HSA-111367.2 SLBP independent Processing of Histone Pre-mRNAs NCBP2 SNRPG LSM10 LSM11 SNRPE SNRPF SNRPD3 ZNF473 SNRPB NCBP1 DISEASES OF METABOLISM%REACTOME%R-HSA-5668914.4 Diseases of metabolism B3GLCT ADAMTS12 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS17 B4GAT1 SFTA3 CFP CYP27B1 CYP11B1 CYP26B1 CYP24A1 G6PC3 CYP26C1 CYP2R1 MUC5AC ADAMTS20 THSD7B C1GALT1C1 THSD7A ALG8 GGT1 ALG9 ALG6 ALG3 ALG1 BTD KHK MUC12 MUC15 SFTPB SFTPD CYP17A1 MUC3A MUC3B MUC16 MUC17 MUC19 SEMA5A MUC20 MUC21 GALK1 UBA52 GALT MUC5B GALE TCN2 ADAMTSL1 POMC ADAMTSL5 ADAMTSL4 ADAMTSL3 ADAMTSL2 LARGE1 ADAMTS2 ADAMTS3 UBB ADAMTS6 ADAMTS7 THSD1 THSD4 CD320 UBC GBE1 RPS27A PGM1 HSPG2 BCAN ALG14 ALG13 ALG12 ALG11 NOTCH1 ADAMTS16 DAG1 ADAMTS18 ARSB ALDOB POMGNT1 RFT1 ADAMTS4 ADAMTS5 THBS2 ADAMTS1 MUC1 MUC2 ADAMTS8 MUC7 GAA MUC4 ADAMTS9 MUC6 DCN EPM2A TALDO1 MMAB G6PC1 RPIA SPON2 SPON1 CUBN PPP1R3C ACAN MMADHC AMN SBSPON NAGLU SLC34A2 DPAGT1 SSPOP LMBRD1 GALNT3 NHLRC1 SGSH IDS GUSB IDUA MCCC2 PC ABCA3 PCCA HLCS MCCC1 HGSNAT PCCB ACACA SFTPC ABCD4 SEMA5B GYG2 GALNS MPDU1 SLC37A4 SFTPA1 MMACHC FDXR MUCL1 CYP1B1 CBLIF GYS2 C1GALT1 HYAL1 GALNT12 CYP2U1 FDX1 FDX2 DCXR POMT2 POMT1 THBS1 ACY1 CSF2RB MGAT2 CSF2RA CYP21A2 MOGS MAN1B1 GSS SLC35D1 MTRR MC2R TPMT CYP4F22 NOTCH2 LFNG CYP19A1 NOTCH3 CYP11A1 SI NOTCH4 LCT MAOA MUC13 GCLC CYP11B2 TBXAS1 GCLM OPLAH FMO3 ALG2 UGT1A1 SLC26A2 B4GALT1 SDC4 SDC2 HEXB SDC3 HEXA PRELP PAPSS2 IDH1 GPC1 PAH GPC3 GPC2 GPC5 GPC4 CHST14 GPC6 ST3GAL3 CHST6 UGT1A4 B3GAT3 LUM OMD KERA B3GALT6 EXT1 EXT2 OGN SDC1 FMOD AGRN MPI GNS B4GALT7 AHCY DPM1 DPM2 DPM3 SFTPA2 GNE NEU1 CTSA CYP7B1 CYP27A1 GFPT1 PMM2 SRD5A3 NCAN DOLK NUS1 MAT1A BGN DHDDS VCAN GLB1 CHSY1 CSPG5 CSPG4 CHST3 MMAA MMUT MTR GYS1 GYG1 BIOSYNTHESIS OF DPAN-3-DERIVED PROTECTINS AND RESOLVINS%REACTOME%R-HSA-9026286.1 Biosynthesis of DPAn-3-derived protectins and resolvins ALOX5 ALOX15 SEMA3A PAK DEPENDENT AXON REPULSION%REACTOME%R-HSA-399954.2 Sema3A PAK dependent Axon repulsion NRP1 LIMK1 PLXNA4 HSP90AA1 PLXNA3 PAK2 FES RAC1 FYN PAK3 PAK1 SEMA3A CFL1 HSP90AB1 PLXNA2 PLXNA1 CHK1 CHK2(CDS1) MEDIATED INACTIVATION OF CYCLIN B:CDK1 COMPLEX%REACTOME%R-HSA-75035.4 Chk1 Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex CDC25C YWHAZ YWHAE WEE1 CHEK1 YWHAB CDK1 YWHAQ YWHAG SFN YWHAH CHEK2 CCNB1 G-PROTEIN ACTIVATION%REACTOME DATABASE ID RELEASE 76%202040 G-protein activation GNG12 GNG11 GNG13 GNA14 GNB2 GNAQ GNB1 GNG3 GNA15 GNB4 GNG2 GNB3 OPRM1 GNG5 GNG4 GNB5 GNG7 PDYN GNA11 GNG8 GNGT1 GNGT2 POMC GNG10 CLASSICAL ANTIBODY-MEDIATED COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 76%173623 Classical antibody-mediated complement activation C1R V1-20 IGHV3-53 IGLC7 IGKV2D-40 IGHV3-11 IGKV5-2 IGLC6 IGHV3-13 C1QC IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGHV3-23 IGLV1-51 IGLV2-23 IGLV2-8 IGKV3-20 IGHV4-34 IGKV1-16 IGHV1-2 IGHV4-39 IGKV1-17 IGKV1-12 IGHV3-7 IGKV2-29 IGHV3-9 IGKV2-28 IGLC3 IGHV3-30 IGLC1 V2-17 IGLC2 IGHV3-33 V1-9 V1-7 V2-15 V1-5 V2-19 V1-3 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV3D-20 V1-11 IGKV2D-30 IGKV2-30 V1-16 IGHV2-70 V1-13 IGHV2-5 IGHV1-69 C1QB IGHV3-48 CRP IGLV3-1 C1QA IGKV1-39 C1S IGKV1-33 INTERLEUKIN-12 SIGNALING%REACTOME DATABASE ID RELEASE 76%9020591 Interleukin-12 signaling RPLP0 MIF ANXA2 VAMP7 PPIA CNN2 STAT4 IL12B AIP IL10 TYK2 IL12RB1 PSME2 HSPA9 MTAP CAPZA1 CFL1 GSTO1 PAK2 IL12A SOD2 P4HB LMNB1 SERPINB2 HNRNPF LCP1 BOLA2B HNRNPDL ARF1 IL12RB2 RAP1B MSN SOD1 PDCD4 JAK2 CDC42 RALA TALDO1 CA1 IFNG SNRPA1 JAK1 TCP1 PITPNA GSTA2 HNRNPA2B1 TRIGLYCERIDE CATABOLISM%REACTOME%R-HSA-163560.3 Triglyceride catabolism MGLL ABHD5 FABP12 PLIN3 PPP1CC PPP1CB LIPE PRKACG PRKACB CAV1 FABP9 PPP1CA FABP1 FABP2 PRKACA FABP3 FABP4 FABP5 FABP6 GPD2 FABP7 PNPLA4 PNPLA5 PLIN1 CROSS-PRESENTATION OF PARTICULATE EXOGENOUS ANTIGENS (PHAGOSOMES)%REACTOME%R-HSA-1236973.1 Cross-presentation of particulate exogenous antigens (phagosomes) ITGAV NCF1 NCF2 NCF4 CD36 CYBB ITGB5 CYBA TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF CELL CYCLE FACTORS%REACTOME DATABASE ID RELEASE 76%8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors TFAP2C MYC CDKN1A KDM5B TFAP2A CHYLOMICRON CLEARANCE%REACTOME DATABASE ID RELEASE 76%8964026 Chylomicron clearance LIPC APOE APOB LDLR LDLRAP1 G BETA:GAMMA SIGNALLING THROUGH CDC42%REACTOME DATABASE ID RELEASE 76%8964616 G beta:gamma signalling through CDC42 GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 GNGT1 GNGT2 ARHGEF6 CDC42 PAK1 GNG10 SIGNALING BY NUCLEAR RECEPTORS%REACTOME%R-HSA-9006931.5 Signaling by Nuclear Receptors CREBBP CBFB PDHB RUNX1 STRN KPNA2 CXCL12 RXRB RXRG YY1 KANK1 ELK1 MAPK1 MAPK3 GNAI3 KDM1A GNAI1 GNAI2 HSP90AA1 MYB CPT1B PPARD ESR2 CYP26A1 CYP26B1 CYP26C1 GATA3 PIK3R2 DDX5 S1PR3 CAV1 DHRS4 RARG RARB CCND1 MYC EREG ATF2 BTC SRC FOXO3 NR1H2 CCNT1 ESR1 TGFA RXRA GTF2A1 RARA GTF2A2 NRIP1 PGR CDK9 POLR2A POLR2B POLR2C POLR2D POLR2E TLE3 POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L CTSD MMP7 H2AC14 GTF2F1 RDH11 H2BC21 EP300 MMP2 H2BU1 GTF2F2 MMP3 H3-3B H3C8 MMP9 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ PCK1 H2BC15 H2BC11 MYLIP ABCG8 HDAC1 ABCG5 H3C15 BCL2 ANGPTL3 H2BS1 ABCG1 CETP EPGN NCOA3 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 APOE H2BC3 H2BC1 ABCA1 APOC4 H2AC20 NR1H3 NCOA1 MED1 APOC2 APOC1 NCOA2 CPT1A TBL1XR1 CARM1 TBL1X CITED1 KAT5 PDK4 PDK3 PDK2 PDK1 KDM3A KCTD6 ARL4C HDAC3 EEPD1 POU2F1 ADH4 GNG10 GNG12 GNG11 GNG13 GNB2 JUND GNB1 NOS3 ADH1C GNB4 PDPK1 ADH1A GNB3 FOSB GNB5 PIK3R1 GNGT1 GNGT2 KDM1B SPHK1 CALM1 HSP90AB1 APOD PTGES3 SMC3 FKBP4 GNG3 FKBP5 PDHX GNG2 EGF CRABP1 GNG5 ZDHHC7 RAD21 DHRS3 GNG4 CRABP2 ALDH1A3 GNG7 GREB1 SDR16C5 NR5A2 DHRS9 GNG8 STAG1 TFF3 ALDH1A2 RDH10 STAG2 TFF1 AXIN1 RDH16 ZNF217 RDH5 EBAG9 RDH14 FOXA1 RDH13 PPID CAV2 SMC1A ALDH8A1 CHD1 CXXC5 XPO1 USF2 USF1 AKT1 SRF PTK2 JUN GPS2 NCOR2 TNRC6C MOV10 CREB1 NCOR1 TNRC6A TNRC6B GPAM FABP5 ALDH1A1 CDKN1B PLIN1 AKT3 DLAT PIK3CA UGT1A3 PRMT1 FOS SCD SP1 AGO3 DLD AGO4 AGO1 AGO2 UHMK1 KDM4A KDM4B PPP5C AKR1C3 AREG FASN FABP6 IGF1R PDHA2 PDHA1 HBEGF EGFR AKT2 GNAT3 HRAS NRAS PIK3R3 PRKCZ ZDHHC21 G2 M DNA REPLICATION CHECKPOINT%REACTOME DATABASE ID RELEASE 76%69478 G2 M DNA replication checkpoint WEE1 PKMYT1 CDK1 CCNB2 CCNB1 DEFECTIVE HK1 CAUSES HEXOKINASE DEFICIENCY (HK DEFICIENCY)%REACTOME DATABASE ID RELEASE 76%5619056 Defective HK1 causes hexokinase deficiency (HK deficiency) HK1 METABOLISM OF RNA%REACTOME%R-HSA-8953854.4 Metabolism of RNA RCL1 TBL3 MPHOSPH10 NOL11 NOP10 HSD17B10 APOBEC1 APOBEC3C APOBEC2 APOBEC4 APOBEC3H A1CF APOBEC3A APOBEC3B PPP2R1A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 CSNK1D UPF3A RPS4X RPS15 RPL7A CSNK1E RPS14 UPF2 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 UPF1 RPS9 RPS7 RPL21 NCBP1 RPS8 NCBP2 RPS5 UBB RPL23 RPL22 RPS6 RPL13A UBC RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 GSPT1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 CCNH RPS23 RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TRMT112 NUP107 NUP188 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 DDX21 PSMD5 PSMD2 PSMD3 NUP210 PSMD1 PSMA5 NUP93 PSMA6 PSMA3 POM121 PSMA4 NUP205 PSMA1 PSMA2 SF3B1 PSME3 PSME4 PSME1 PSME2 PSMD10 AAAS PSMB11 PSMD12 PSMD11 NUP160 POM121C PSMD14 NUP85 PSMD13 TPR NUP88 PSMA7 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 PSMB4 NUP153 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 ISY1 SEM1 PSMC5 PRPF19 PSMC6 PSMC3 PSMC4 AQR PSMC1 PSMC2 PPIE ADAR NUP62 ADARB1 NDC1 POP5 POP7 XAB2 NUP133 POP1 TSEN15 POP4 RPP30 RTCB ZBTB8OS TSEN2 NUP50 TSEN54 NUP54 CLP1 WDR61 RPP38 RPP21 TNFSF13 RPP25 TSEN34 DDX1 CSTF2 RPP14 C2orf49 NUP42 RTRAF NUP43 RAE1 CPSF1 RANBP2 RPP40 XPOT FAM98B RAN NUP35 LSM10 NUP37 LSM11 XRN2 SKIV2L DHX9 NOP56 ZNF473 RRP1 LAS1L SMG1 SMG9 SMG7 SMG8 SMG5 SMG6 RIOK2 RIOK1 TEX10 GNL3 NIP7 EXOSC10 RIOK3 WDR18 WDR12 BYSL TSR1 FTSJ3 EBNA1BP2 NCL ISG20L2 NOB1 C1D IGF2BP1 IGF2BP3 IGF2BP2 PNRC2 LTV1 ERI1 NOL12 NOL9 PES1 BOP1 MPHOSPH6 RBM28 SENP3 PELP1 EIF4E EIF4B NOP2 PABPN1 CPSF4 PHAX NSUN4 MTERF4 PPP2R2A TFB1M MRM1 MRM2 MRM3 ZCRB1 DDX5 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 SNRPD3 SRRM2 METTL3 CRNKL1 CD2BP2 SF1 SLBP CSTF3 SNU13 RNPC3 PCBP1 CSTF1 SYMPK ZRSR2 PRPF38A HNRNPL HNRNPM HNRNPK HNRNPF SUGP1 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SRSF10 SF3A3 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CWC27 EFTUD2 CWC22 PAPOLA MTREX TXNL4A SNRNP35 SNRPN SNW1 WBP11 PRPF4 PRPF6 HNRNPUL1 NXT1 PRPF3 SNRPG EIF4A3 CASC3 SNRNP27 GLE1 PPIH SNRPE MAGOH THOC1 SNRPF THOC3 SNRNP25 THOC2 SNRPC THOC5 SNRNP200 SNRPA CDC40 THOC7 SNRPB THOC6 PRPF8 DDX39A ZMAT5 DDX39B FUS ZC3H11A CPSF3 SARNP CPSF2 SRSF2 CWC15 SRSF3 LSM5 SRSF4 LSM4 SRSF5 LSM3 SRSF6 LSM2 SRSF7 CHERP LSM8 SLU7 SRSF9 LSM7 LSM6 FYTTD1 LUZP4 DDX46 RBM8A DDX42 PPWD1 POLDIP3 SRSF1 YBX1 U2AF1 USP39 ELAVL2 U2AF1L4 PTBP1 NXF1 SART1 U2AF2 PCBP2 SEC13 METTL14 DHX38 SRSF11 SNRNP70 CHTOP RBM5 BCAS2 ALYREF UPF3B CTNNBL1 MAGOHB RBM17 NXF2B BUD31 TFIP11 RNPS1 PLRG1 SYF2 SNRPA1 DNAJC8 RBM22 WBP4 DDX23 PRCC CSTF2T PUF60 FIP1L1 SNRPB2 HNRNPA1 SMNDC1 HNRNPA0 HNRNPA3 PPIL1 WTAP GPKOW CDC5L U2SURP SNRNP40 SNRNP48 PPIL3 PPIL4 PPIL6 TGS1 TP53RK GEMIN2 WDR77 CLNS1A PPP2CA GEMIN4 GEMIN5 PRMT5 GEMIN6 GEMIN7 GEMIN8 DDX20 SMN2 HSPA8 SNUPN YWHAB HSPB1 ELAVL1 ZFP36 XPO1 KHSRP AKT1 TNPO1 NUP214 DIS3 NOP58 PRKCD PRKCA YWHAZ XRN1 MAPKAPK2 PABPC1 DCP2 SET ANP32A PARN ZFP36L1 EXOSC7 EXOSC6 EXOSC5 TRMU EXOSC4 MTO1 EXOSC9 TRIT1 EXOSC8 TRMT61B EXOSC3 GTPBP3 EXOSC2 EXOSC1 MAPK14 MAPK11 THG1L DCP1A ALKBH8 EIF4G1 HSPA1A TRMT44 PUS3 TYW5 EPRS1 METTL1 TYW3 CDKAL1 PUS7 FTSJ1 THADA OSGEP TRMT9B TRMT12 TRMT13 TRMT11 WDR4 NSUN2 NSUN6 TNKS1BP1 QTRT1 DUS2 CNOT6L QTRT2 CTU2 CTU1 URM1 TYW1 LCMT2 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ADAT2 TRMT5 TRMT6 TRMT61A CNOT10 CNOT4 CNOT6 CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 CNOT9 HBS1L TUT7 TUT4 EIF4A2 EDC3 EDC4 EIF4A1 TTC37 PATL1 NT5C3B DDX6 DCPS CPSF7 PAIP1 LSM1 PAN2 PAN3 DCP1B SRRM1 DDX49 DDX47 WDR3 TRA2B FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 HNRNPC FBL BUD23 RBMX UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DIEXF TRMT10C DKC1 PRORP NHP2 TSR3 ELAC2 HEATR1 TRNT1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 GAR1 RRP36 UTP20 DCAF13 UTP6 NOP14 UTP4 PNO1 KRR1 UTP3 COLLAGEN BIOSYNTHESIS AND MODIFYING ENZYMES%REACTOME%R-HSA-1650814.4 Collagen biosynthesis and modifying enzymes COL5A3 COL7A1 COL6A2 COL4A3 PLOD3 COL5A2 PLOD2 COL6A1 PLOD1 COL20A1 COL8A2 COL4A6 COL4A5 COL21A1 BMP1 COL8A1 COL9A1 COL6A3 COL9A3 COL6A6 PPIB COL9A2 COL18A1 COL6A5 COL14A1 CRTAP P4HA1 P4HA2 P4HA3 COLGALT2 ADAMTS14 COLGALT1 PCOLCE2 COL25A1 COL15A1 COL19A1 COL26A1 TLL2 TLL1 COL16A1 ADAMTS2 COL12A1 ADAMTS3 P4HB PCOLCE COL11A1 COL11A2 COL10A1 COL23A1 COL28A1 COL27A1 COL24A1 P3H2 COL22A1 P3H1 COL1A1 P3H3 COL3A1 COL2A1 SERPINH1 COL1A2 COL17A1 COL5A1 COL4A2 COL13A1 COL4A1 COL4A4 DECTIN-2 FAMILY%REACTOME DATABASE ID RELEASE 76%5621480 Dectin-2 family MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 MUC19 MUC20 MUC21 SYK MUC5B FYN MUC1 env MUC2 CLEC4C CLEC4D MUC13 LYN FCER1G MUC7 MUC4 MUC6 CLEC10A CLEC4A CLEC4E CLEC6A MUCL1 MUC5AC PLCG2 PI-3K CASCADE:FGFR3%REACTOME DATABASE ID RELEASE 76%5654710 PI-3K cascade:FGFR3 GAB1 FGF1 FGF2 PIK3CA FGF4 PTPN11 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF18 TWIK-RELEATED ACID-SENSITIVE K+ CHANNEL (TASK)%REACTOME DATABASE ID RELEASE 76%1299316 TWIK-releated acid-sensitive K+ channel (TASK) KCNK3 KCNK9 GLUTAMATE BINDING, ACTIVATION OF AMPA RECEPTORS AND SYNAPTIC PLASTICITY%REACTOME%R-HSA-399721.3 Glutamate binding, activation of AMPA receptors and synaptic plasticity PRKCB PRKCG MDM2 MYO6 GRIA2 DLG1 TSPAN7 DLG4 GRIA3 EPB41L1 GRIA4 PRKCA CAMK2B CAMK2D CAMK2A NSF CACNG8 CACNG2 CACNG3 CAMK2G AKAP5 PICK1 CACNG4 AP2A1 GRIP1 GRIA1 GRIP2 SIGNALING BY ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 76%9665686 Signaling by ERBB2 TMD JMD mutants NRG1 HSP90AA1 NRG2 NRG3 CDC37 HRAS NRG4 ERBB2 ERBIN SHC1 PLCG1 SOS1 EGF NRAS HBEGF EGFR EREG BTC NUCLEOTIDE METABOLISM%REACTOME%R-HSA-15869.5 Nucleotide metabolism PFAS ATIC GUK1 PPAT TK2 NME2P1 NUDT13 ADSL SAMHD1 CAD CTPS2 NME3 CTPS1 NME4 TXNRD1 NME1 DCTD CMPK1 UMPS GART DCTPP1 DTYMK AK1 AK2 GMPS CDA AK4 GLRX GDA AK5 DPYS AK6 NT5C2 AK7 NUDT5 AK8 DNPH1 AK9 NME2 TYMP LHPP NT5C RRM1 UPP2 PAICS NT5M UCKL1 NUDT16 NT5E DHODH UPP1 UCK2 NUDT15 UCK1 ENTPD2 PUDP ENTPD3 ADSS1 ENTPD4 ADSS2 ENTPD6 ENTPD7 ENTPD8 UPB1 RRM2 NT5C1A NT5C1B DPYD ADPRM ITPA IMPDH1 TK1 IMPDH2 TYMS AGXT2 RRM2B GMPR2 ADK GMPR AMPD1 AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP HPRT1 ADA ENTPD1 ENTPD5 TXN XDH KERATAN SULFATE KERATIN METABOLISM%REACTOME%R-HSA-1638074.1 Keratan sulfate keratin metabolism ST3GAL3 CHST6 LUM OMD KERA OGN FMOD GNS GLB1L B4GAT1 ST3GAL4 ST3GAL1 ST3GAL2 B4GALT2 B4GALT3 B3GNT7 B3GNT4 B3GNT3 CHST1 ST3GAL6 B3GNT2 B4GALT6 CHST5 B4GALT4 B4GALT1 CHST2 B4GALT5 HEXB SLC35D2 HEXA PRELP ACAN GLB1 REGULATION OF TP53 ACTIVITY THROUGH PHOSPHORYLATION%REACTOME DATABASE ID RELEASE 76%6804756 Regulation of TP53 Activity through Phosphorylation CCNA1 RHNO1 BLM TP53 BRIP1 NUAK1 CDK2 MDM2 ATRIP ATM MDM4 BARD1 SUPT16H PLK3 CSNK2A1 TAF9 SSRP1 RAD17 TAF1L RAD9B CSNK2A2 ATR TAF7L RAD9A TAF9B DYRK2 TAF15 CSNK2B TAF12 TAF13 BRCA1 TAF10 TAF11 TAF7 TAF4B EXO1 TAF6 TAF5 TOPBP1 TAF4 RFC5 TAF3 TAF2 RMI2 TAF1 RFC3 RFC4 PRKAB2 RFC2 RMI1 PRKAA2 PRKAG1 TOP3A PRKAG2 TBP PRKAB1 WRN PRKAG3 TP53INP1 RBBP8 RPA1 CHEK1 RPA2 HIPK1 RAD50 PIN1 RPA3 RAD1 CDK5R1 TPX2 CDK5 UBA52 PRKAA1 STK11 AURKA UBB UBC RPS27A AURKB HIPK2 MRE11 TP53RK NOC2L KAT5 MAPK14 MAPK11 NBN HUS1 CHEK2 MAPKAPK5 CCNA2 DNA2 SIGNALING BY NOTCH4%REACTOME DATABASE ID RELEASE 76%9013694 Signaling by NOTCH4 PSEN1 CREBBP HES1 NCSTN SMAD3 HEY1 SNW1 HEY2 ACTA2 MAMLD1 RBX1 EP300 PSEN2 APH1A APH1B KAT2B KAT2A TACC3 SKP1 PSMD8 DLL4 PSMD9 HES5 PSMD6 PSMD7 PSMD4 PSENEN PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 JAG1 PSME1 PSME2 UBA52 PSMD10 PSMD12 NOTCH2 PSMD11 PSMD14 PSMD13 NOTCH4 PSMA7 PSMB10 CUL1 AKT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 FLT4 YWHAZ PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 MAML2 PSMC1 MAML1 PSMC2 RBPJ ADAM10 MAML3 NOTCH1 INOSITOL TRANSPORTERS%REACTOME%R-HSA-429593.2 Inositol transporters SLC5A11 SLC2A13 SLC5A3 BIOSYNTHESIS OF ASPIRIN-TRIGGERED D-SERIES RESOLVINS%REACTOME%R-HSA-9020265.1 Biosynthesis of aspirin-triggered D-series resolvins ALOX5 LTA4H POLB-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 76%110362 POLB-Dependent Long Patch Base Excision Repair PARG APEX1 LIG1 ADPRS POLB PARP1 FEN1 PARP2 TGFBR1 LBD MUTANTS IN CANCER%REACTOME%R-HSA-3656535.1 TGFBR1 LBD Mutants in Cancer TGFB1 TGFBR1 TGFBR2 FKBP1A DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NTHL1%REACTOME DATABASE ID RELEASE 76%9616333 Defective Base Excision Repair Associated with NTHL1 NTHL1 REPRODUCTION%REACTOME DATABASE ID RELEASE 76%1474165 Reproduction BLM ATR BRCA1 FKBP6 PRDM9 TOP3A ACD TINF2 TERF1 TERF2 RBBP8 RPA1 H3-4 POT1 RPA2 TERF2IP RAD50 RPA3 HSPA2 SMC3 RAD21 STAG1 STAG2 SMC1A LMNB1 CDK4 BRCA2 RAD51 B4GALT1 RAD51C UBE2I CDK2 ATM MLH1 H2AX H2AB1 H2AC19 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 MSH4 H2BC11 MSH5 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SPO11 CATSPER1 SYCP1 CATSPER3 SYNE2 CATSPER2 SYNE1 CATSPER4 H3C15 HVCN1 SUN2 SUN1 ADAM21 TEX12 ADAM20 OVGP1 TEX15 IZUMO3 SMC1B IZUMO2 DMC1 H2BS1 IZUMO4 PSMC3IP IZUMO1 MND1 ADAM30 MLH3 ADAM2 REC8 ACR H2AZ1 SYCP3 KCNU1 H2BC9 CATSPERB CATSPERD H2AZ2 H4C9 CATSPERG H2BC8 CD9 ZP1 H2BC5 ZP3 ZP2 H2BC3 SPAM1 ZP4 H2BC1 H2AC20 MRE11 NBN RUNX1 REGULATES EXPRESSION OF COMPONENTS OF TIGHT JUNCTIONS%REACTOME DATABASE ID RELEASE 76%8935964 RUNX1 regulates expression of components of tight junctions CBFB RUNX1 OCLN TJP1 CLDN5 REGULATION OF TLR BY ENDOGENOUS LIGAND%REACTOME DATABASE ID RELEASE 76%5686938 Regulation of TLR by endogenous ligand GSDMD LBP FGB LY96 FGA APOB CD14 TLR4 TLR1 FGG GSDME S100A1 HMGB1 S100A9 S100A8 TLR2 TLR6 CD36 P53-INDEPENDENT DNA DAMAGE RESPONSE%REACTOME DATABASE ID RELEASE 76%69610 p53-Independent DNA Damage Response CHEK1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHEK2 GLYCOGEN SYNTHESIS%REACTOME DATABASE ID RELEASE 76%3322077 Glycogen synthesis GYG1 PGM2L1 UBB UGP2 UBC GBE1 RPS27A GYG2 PGM1 NHLRC1 EPM2A UBA52 GYS2 PGM2 PPP1R3C GYS1 SUMOYLATION OF RNA BINDING PROTEINS%REACTOME DATABASE ID RELEASE 76%4570464 SUMOylation of RNA binding proteins CBX8 NUP42 NUP210 CBX4 NUP43 CBX2 RAE1 PHC2 RANBP2 PHC1 NUP93 BMI1 RING1 POM121 SUMO1 NUP205 SUMO2 NUP35 NUP37 AAAS PHC3 NUP160 POM121C NUP85 TPR NUP88 NUP155 HNRNPC NUP214 NUP153 NOP58 HNRNPK RNF2 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 PCGF2 NUP50 NUP54 UBE2I PI AND PC TRANSPORT BETWEEN ER AND GOLGI MEMBRANES%REACTOME%R-HSA-1483196.2 PI and PC transport between ER and Golgi membranes PITPNB REGULATION OF ACTIN DYNAMICS FOR PHAGOCYTIC CUP FORMATION%REACTOME DATABASE ID RELEASE 76%2029482 Regulation of actin dynamics for phagocytic cup formation V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV CYFIP1 V5-4 NCKAP1 V5-1 ARPC4 SYK ARPC5 VAV3 V5-6 MAPK1 BRK1 VAV1 IGLV3-19 ARPC2 ELMO2 ARPC3 MAPK3 WAS HSP90AA1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 MYH9 IGKV1-5 ACTR2 MYO9B WASL VAV2 IGLV IGHG3 CDC42 IGHG4 PAK1 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 HSP90AB1 IGKV1D-33 NCK1 ABL1 IGHV4-59 NCKAP1L WASF1 IGLV2-11 NCKIPSD WASF2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MYO1C IGKV3-15 NF2 BAIAP2 IGKV3-11 V2-8 ABI2 IGLV7-43 ARPC1B ABI1 ACTG1 IGKV1D-16 CFL1 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 LIMK1 PTK2 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 FCGR2A MYO5A BTK ACTB CD3G ARPC1A ELMO1 CRK CYFIP2 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 ACTIVATION OF PUMA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 76%139915 Activation of PUMA and translocation to mitochondria TP53 TP73 TFDP1 TFDP2 PPP1R13B TP53BP2 BBC3 E2F1 TP63 B CELL ACTIVATION%REACTOME DATABASE ID RELEASE 76%983705 B Cell Activation PRKCB IGKV2D-40 IGHV3-11 PPP3R1 IGHV3-13 IGHV1-46 NFATC1 IGHV SYK STIM1 FYN ORAI2 ORAI1 BCL10 VAV1 IGLV3-19 ITPR1 ITPR2 ITPR3 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-5 PIK3R1 IGLV BTRC NFKB1 PTPN6 CALM1 SKP1 NFKBIB IGKV1D-39 IGKV1D-33 NCK1 FBXW11 PIK3AP1 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 NFATC2 IGLV2-14 UBA52 IGLV1-44 IGKV3-15 IGKV3-11 IGLV7-43 CUL1 IGKV1D-16 IGKV1D-12 LYN IGLV1-51 IGLV2-23 UBB IGKV3-20 IGHV4-34 IGHV1-2 UBC IGHV4-39 IGKV2-29 RPS27A IGKV2-28 CARD11 IGLC3 IGLC1 NFATC3 IGLC2 MALT1 BLK PIK3CD IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 SOS1 TRPC1 BTK SH3KBP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PPIA PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 DAPP1 PSME2 RASGRP3 PSMD10 CD79B CD79A PSMB11 PSMD12 REL PSMD11 NFKBIE PSMD14 CD22 PSMD13 IGHM BLNK IGHD PSMA7 AHCYL1 PSMB10 PSMA8 PSMB6 PSMB7 IGHV3-23 PSMB4 PSMB5 IGLV2-8 PSMB2 IKBKB PSMB3 IGKV1-16 PSMB1 PSMF1 HRAS IGKV1-17 CHUK IGKV1-12 NFKBIA PSMB8 IGHV3-7 RELA PSMB9 IGHV3-9 SEM1 IKBKG PSMC5 IGHV3-30 PSMC6 PSMC3 IGHV3-33 RASGRP1 NRAS PSMC4 PSMC1 PSMC2 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV2D-30 IGHV1-69 PPP3CA FKBP1A PPP3CB PLCG2 MAP3K7 CD19 UNCOATING OF THE HIV VIRION%REACTOME%R-HSA-162585.1 Uncoating of the HIV Virion gag rev gag-pol vif PPIA vpr nef vpu PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%75896 Plasmalogen biosynthesis GNPAT DHRS7B AGPS BIOSYNTHESIS OF MARESIN CONJUGATES IN TISSUE REGENERATION (MCTR)%REACTOME%R-HSA-9026762.1 Biosynthesis of maresin conjugates in tissue regeneration (MCTR) GSTM4 LTC4S PROLINE CATABOLISM%REACTOME DATABASE ID RELEASE 76%70688 Proline catabolism PRODH PRODH2 ALDH4A1 SUMO IS PROTEOLYTICALLY PROCESSED%REACTOME%R-HSA-3065679.2 SUMO is proteolytically processed SENP5 SENP2 SENP1 SUMO1 SUMO3 SUMO2 RAS PROCESSING%REACTOME%R-HSA-9648002.2 RAS processing ABHD17A GOLGA7 FNTB HRAS PRKG2 BCL2L1 NRAS KRAS USP17L2 RCE1 FNTA PDE6D PRKCQ LYPLA1 CALM1 ARL2 ICMT ABHD17C ZDHHC9 ABHD17B MATURATION OF PROTEIN 3A%REACTOME DATABASE ID RELEASE 76%9694719 Maturation of protein 3a ST3GAL4 ST6GALNAC3 ST6GALNAC4 ST3GAL3 ST3GAL1 3a ST3GAL2 ST6GAL1 ST6GALNAC2 GALNT1 WNT5A-DEPENDENT INTERNALIZATION OF FZD2, FZD5 AND ROR2%REACTOME DATABASE ID RELEASE 76%5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 CLTC AP2A1 CLTB AP2B1 AP2A2 AP2S1 ROR1 ROR2 WNT5A FZD5 AP2M1 CLTA SUPPRESSION OF APOPTOSIS%REACTOME DATABASE ID RELEASE 76%9635465 Suppression of apoptosis RNF213 lprM SFPQ MAPK1 TRIM27 GSK3A Rv3655c Rv3654c MAPK3 CTSG Rv3364c ptpA CLEC7A (DECTIN-1) SIGNALING%REACTOME%R-HSA-5607764.1 CLEC7A (Dectin-1) signaling TAB1 UBE2V1 PPP3R1 CASP8 NFATC1 SYK CDC34 BCL10 IL1B ITPR1 ITPR2 ITPR3 PDPK1 BTRC PYCARD NFKB1 CALM1 SKP1 FBXW11 RELB UBA3 MAP3K14 NFATC2 UBE2M UBA52 CARD9 CUL1 PRKCD UBB UBC RPS27A CARD11 CLEC7A NFATC3 MALT1 UBE2D2 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 AHCYL1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 CHUK NFKBIA PSMB8 RELA PSMB9 SEM1 NFKB2 IKBKG PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PPP3CA TRAF6 UBE2N PPP3CB PLCG2 TAB3 MAP3K7 TAB2 PCNA-DEPENDENT LONG PATCH BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 76%5651801 PCNA-Dependent Long Patch Base Excision Repair POLD2 RFC5 POLE4 RFC3 RFC4 RFC2 POLE2 POLE3 POLE LIG1 POLB RFC1 PCNA RPA1 RPA2 APEX1 RPA3 POLD3 FEN1 POLD4 POLD1 DISPLACEMENT OF DNA GLYCOSYLASE BY APEX1%REACTOME DATABASE ID RELEASE 76%110357 Displacement of DNA glycosylase by APEX1 SMUG1 MPG OGG1 NTHL1 APEX1 TDG MBD4 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO ATRX MUTATIONS%REACTOME DATABASE ID RELEASE 76%9670615 Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations DAXX ATRX DEFECTIVE SLC26A3 CAUSES CONGENITAL SECRETORY CHLORIDE DIARRHEA 1 (DIAR1)%REACTOME DATABASE ID RELEASE 76%5619085 Defective SLC26A3 causes congenital secretory chloride diarrhea 1 (DIAR1) SLC26A3 SIGNALLING TO RAS%REACTOME%R-HSA-167044.4 Signalling to RAS MAPK12 MAPK13 NGF MAPKAPK3 HRAS MAPKAPK2 SHC1 SOS1 NRAS SHC2 MAPK14 MAPK11 RALGDS RALA RALB SHC3 NTRK1 ABERRANT REGULATION OF MITOTIC G1 S TRANSITION IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 76%9659787 Aberrant regulation of mitotic G1 S transition in cancer due to RB1 defects CDKN1C CCNE2 RB1 CCNE1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CDK2 CCND1 CDK4 E2F1 E2F2 E2F3 CDKN1A CDKN1B DEFECTIVE ABCG8 CAUSES GBD4 AND SITOSTEROLEMIA%REACTOME DATABASE ID RELEASE 76%5679090 Defective ABCG8 causes GBD4 and sitosterolemia ABCG8 ABCG5 MITOCHONDRIAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 76%1268020 Mitochondrial protein import TOMM22 CHCHD4 CHCHD5 CHCHD2 CHCHD3 CHCHD7 CMC4 CMC2 PAM16 BCS1L COX17 HSPA9 ATP5MC1 TIMM50 PITRM1 GRPEL1 LDHD GRPEL2 TOMM70 CYC1 COA4 DNAJC19 CHCHD10 TIMM44 TIMM10B CS COQ2 COX19 ACO2 HSCB TAZ TIMM17A TIMM17B OTC COA6 TIMM23 TOMM20 TIMM22 TIMM21 FXN NDUFB8 TOMM40 VDAC1 TIMM9 TIMM13 TIMM10 ATP5F1A ATP5F1B TIMM8B TIMM8A MTX2 IDH3G SLC25A4 GFER SLC25A6 TOMM7 TOMM5 TOMM6 PMPCB PMPCA SLC25A12 SAMM50 MTX1 SLC25A13 HSPD1 LYSOSOMAL OLIGOSACCHARIDE CATABOLISM%REACTOME%R-HSA-8853383.1 Lysosomal oligosaccharide catabolism MAN2B2 MAN2C1 MAN2B1 MANBA SEROTONIN RECEPTORS%REACTOME%R-HSA-390666.3 Serotonin receptors HTR1F HTR7 HTR1D HTR2B HTR5A HTR1A HTR2C HTR1B HTR2A HTR4 HTR6 HTR1E RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF HSCS%REACTOME%R-HSA-8939236.1 RUNX1 regulates transcription of genes involved in differentiation of HSCs CBFB RUNX1 TP73 MYB TCF3 SPI1 TAL1 KMT2A GATA3 GATA2 GATA1 ABL1 UBA52 UBB TCF12 UBC RPS27A YAP1 CCNH H2AX H2AB1 H2AC19 H2AC14 H2BC21 H2BU1 H3-3B CDK7 H3C8 H2AC8 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ ITCH H2BC15 H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 H2BS1 PSMA4 PSMA1 LDB1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 PSMD10 H2AZ2 H4C9 PSMB11 PSMD12 H2BC8 PSMD11 H2BC5 PSMD14 PSMD13 H2BC3 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 PSMB7 H2AC20 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 LMO1 LMO2 CDT1 ASSOCIATION WITH THE CDC6:ORC:ORIGIN COMPLEX%REACTOME DATABASE ID RELEASE 76%68827 CDT1 association with the CDC6:ORC:origin complex MCM8 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 GMNN PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DISEASES OF HEMOSTASIS%REACTOME%R-HSA-9671793.2 Diseases of hemostasis F2 F10 F8 VWF GP1BB KLKB1 F12 F11 GP1BA GP5 GP9 F9 SERPING1 GGCX TPST2 TPST1 SIGNALING BY ACTIVIN%REACTOME%R-HSA-1502540.2 Signaling by Activin ACVR1B ACVR2B ACVR2A FST SMAD4 DRAP1 ACVR1C SMAD3 FSTL3 INHBB INHBA SMAD2 FOXH1 GOLGI-TO-ER RETROGRADE TRANSPORT%REACTOME DATABASE ID RELEASE 76%8856688 Golgi-to-ER retrograde transport RAB6B PLA2G4A COPE USE1 KIF28P KIF5C BICD1 KIF5B BICD2 KIF5A KIF21A KIF21B KIFAP3 ACTR1A KIF16B KIF20A KIF20B ARFGAP3 DCTN6 ARFGAP1 DCTN5 ARFGAP2 DCTN1 KLC1 SEC22B DCTN4 DYNLL2 RAB1A AGPAT3 KLC4 KLC3 KLC2 RAB1B KIF3B RACGAP1 KIF3C BNIP1 DYNLL1 GALNT2 GALNT1 KIF18A KIF18B KIF4B KIF4A PAFAH1B1 DYNC1I2 DCTN2 RAB18 DCTN3 KDELR1 KIF12 KIF11 KIF15 KIF19 CAPZB KIF13B DYNC1H1 KIF1C KIF1B KIF1A KIF25 KIF23 KIF22 KIF6 KIF27 ZW10 KIF9 KIF2A KDELR2 KIFC2 KDELR3 KIFC1 KIF2C KIF2B DYNC1LI1 DYNC1LI2 PLA2G6 CENPE SURF4 KIF26A KIF26B CAPZA1 CAPZA2 KIF3A ARF3 TMED3 TMED2 ARF4 TMED7 ARF1 TMED9 NAPA NAPB STX18 COPZ2 NAPG COPZ1 DYNC1I1 GBF1 PAFAH1B3 CAPZA3 PAFAH1B2 ARF5 RAB3GAP2 NBAS COPG2 COPG1 ACTR10 RAB3GAP1 ARCN1 NSF RINT1 COPB2 COPA TMED10 COPB1 RAB6A INTRACELLULAR METABOLISM OF FATTY ACIDS REGULATES INSULIN SECRETION%REACTOME%R-HSA-434313.2 Intracellular metabolism of fatty acids regulates insulin secretion CD36 ACSL3 CELL DIVISION%REACTOME DATABASE ID RELEASE 76%68884 cell division SMC3 MAU2 NIPBL RAD21 KIF20A PLK1 STAG1 STAG2 KIF23 PDS5B PDS5A SMC1A WAPL DEFECTIVE SLC4A4 CAUSES RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL RETARDATION (PRTA-OA)%REACTOME DATABASE ID RELEASE 76%5619054 Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA) SLC4A4 ECM PROTEOGLYCANS%REACTOME%R-HSA-3000178.4 ECM proteoglycans TNXB PTPRS DSPP DAG1 COMP ITGA8 LUM IBSP TNN TNR COL9A1 COL9A3 COL9A2 ITGB1 FMOD AGRN LAMC1 HAPLN1 ASPN ITGA7 LAMA4 LRP4 DCN LAMA5 LAMA3 NCAN BGN ACAN VCAN TNC DMP1 LAMB1 ITGA2B LAMA2 LAMA1 NCAM1 ITGAX ITGB3 MATN3 VTN ITGAV SPARC ITGA2 TGFB1 HSPG2 MUSK BCAN LAMB2 ITGA9 ITGB6 MATN1 ITGB5 SERPINE1 MATN4 TGFB2 TGFB3 DEFECTIVE MAOA CAUSES BRUNS%REACTOME%R-HSA-5579012.2 Defective MAOA causes BRUNS MAOA MYD88 DEFICIENCY (TLR2 4)%REACTOME%R-HSA-5602498.1 MyD88 deficiency (TLR2 4) MYD88 FGB LY96 FGA CD14 TLR4 TLR1 FGG S100A1 HMGB1 S100A9 TIRAP S100A8 mip TLR2 BTK porB TLR6 CD36 MITOCHONDRIAL TRNA AMINOACYLATION%REACTOME%R-HSA-379726.1 Mitochondrial tRNA aminoacylation LARS2 SARS2 PPA2 TARS2 AARS2 HARS2 IARS2 WARS2 QARS1 FARS2 GARS1 YARS2 NARS2 RARS2 CARS2 VARS2 KARS1 MARS2 PARS2 DARS2 EARS2 SMAD4 MH2 DOMAIN MUTANTS IN CANCER%REACTOME%R-HSA-3311021.1 SMAD4 MH2 Domain Mutants in Cancer SMAD4 SMAD3 SMAD2 TRANSLESION SYNTHESIS BY POLI%REACTOME%R-HSA-5656121.1 Translesion synthesis by POLI REV3L RFC5 UBB RFC3 UBC RFC4 RFC2 POLI RPS27A RFC1 PCNA RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 BASIGIN INTERACTIONS%REACTOME DATABASE ID RELEASE 76%210991 Basigin interactions SLC3A2 SLC7A6 SLC7A8 L1CAM PPIA SLC16A1 ITGB1 SLC7A5 CAV1 ATP1B3 ATP1B2 ATP1B1 ITGA3 SLC16A8 SLC16A3 MAG MMP1 SPN SLC7A11 PPIL2 SLC7A10 BSG ITGA6 SLC7A7 SLC7A9 TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS%REACTOME DATABASE ID RELEASE 76%168271 Transport of Ribonucleoproteins into the Host Nucleus NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 KPNA1 NUP214 NUP153 PA PB2 NP KPNB1 PB1 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181430.3 Norepinephrine Neurotransmitter Release Cycle SNAP25 SYT1 UNC13B RAB3A CPLX1 RIMS1 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 VAMP2 PPFIA2 SLC22A2 SLC22A1 SLC18A2 MAOA REGULATION OF TP53 EXPRESSION AND DEGRADATION%REACTOME%R-HSA-6806003.2 Regulation of TP53 Expression and Degradation CCNA1 PPP2R1B TP53 MAPKAP1 CDKN2A CDK2 MDM2 ATM MDM4 PPP2R5C UBA52 PRR5 AKT2 MLST8 AKT1 USP2 PPP2CA PPP2CB UBB MTOR UBC RPS27A PDPK1 DAXX USP7 SGK1 RNF34 PPP2R1A RICTOR RFFL PRDM1 CDK1 CCNG1 PHF20 CHEK2 AKT3 CCNA2 ACETYLATION%REACTOME%R-HSA-156582.2 Acetylation NAT1 NAT2 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF ADENYLATE CYCLASE%REACTOME DATABASE ID RELEASE 76%442720 CREB1 phosphorylation through the activation of Adenylate Cyclase ADCY8 PRKX PRKAR1B PRKAR2B PRKAR1A PRKACA PRKAR2A CALM1 PRKACG PRKACB CREB1 ADCY1 INTEGRATION OF VIRAL DNA INTO HOST GENOMIC DNA%REACTOME DATABASE ID RELEASE 76%175567 Integration of viral DNA into host genomic DNA gag BANF1 rev gag-pol vif HMGA1 vpr PSIP1 vpu HCMV INFECTION%REACTOME%R-HSA-9609646.2 HCMV Infection SCP ITGB1 CVC2 CVC1 ELK1 NEC1 NEC2 US12 US11 US10 US28 US27 US26 US24 US34 US32 US30 US19 US18 US17 US16 US14 US13 VPS37C US23 VPS37D US22 VPS37A US20 VPS37B UL147A VPS4A UL103 UL102 DYNLL1 UL104 DYNC1I2 PML HNRNPK CHMP1A UL119/UL118 UL11 UL18 UL17 UL16 UL14 UL13 DYNC1H1 UL32 UL31 HELI UL38 UL37 UL35 UL34 UL29 UL27 UL26 UL25 UL24 UL23 UL54 DBP UL52 CBX1 UL44 UL43 UL48 UL47 UL76 UL74 UL71 UL70 UL79 UL78 UL131A UL41A UL69 UL112/UL113 UL91 UL99 UL98 UL97 UL96 UL36 UL95 UL94 UL92 H2AC19 UL80 UL88 UL87 H2AC14 UL84 H2BC21 UL83 UL82 H2BU1 UL2 UL4 H3C8 UL5 H2AC8 UL7 UL9 H2AC6 UL22A H2AC7 SEC13 H2BC17 US3 H2BC12 US2 H2BC13 US9 US8 H2BC14 MCP H2BC15 DUT NUP107 RL11 NUP188 RL10 H2BC11 US33A US34A RL9A RL8A H3C15 DYNC1I1 NUP210 RBBP4 NUP93 POM121 RBBP7 NUP205 UL15A UL130 H2BC9 UL132 UL133 AAAS H4C9 UL138 TRM3 H2BC8 TRM2 H2BC5 NUP160 POM121C TRM1 NUP85 UL144 H2BC3 UL147 TPR NUP88 UL146 H2BC1 UL148 gB NUP155 gH gL H2AC20 gM NUP153 gN UL114 UL121 UL120 IRS1 UL123 UL122 UL124 UL117 TRS1 TBL1XR1 RL1 CHMP4C CHMP4B TBL1X CHMP4A CEBPD NUP62 TRX1 NDC1 TRX2 UL111A TSG101 NUP133 UL21A NUP50 NUP54 HDAC3 H2AC17 H2AC12 NUP42 NUP43 RAE1 RANBP2 NUP35 CHMP2B NUP37 H2AC21 CHMP2A H2AW CHMP3 CHMP6 CHMP7 NFKB1 H2AC1 DYNLL2 MVB12B MVB12A EZH2 H2BC18 EED NUP214 SUZ12 GPS2 DAXX NCOR2 CREB1 NCOR1 VPS36 DYNC1LI1 DYNC1LI2 VPS25 VPS28 RIR1 SNF8 EGFR TRIM28 UBAP1 INHIBITION OF MEMBRANE REPAIR%REACTOME DATABASE ID RELEASE 76%9635644 Inhibition of membrane repair esxH esxG HGS ADRENALINE SIGNALLING THROUGH ALPHA-2 ADRENERGIC RECEPTOR%REACTOME DATABASE ID RELEASE 76%392023 Adrenaline signalling through Alpha-2 adrenergic receptor ADRA2C ADRA2B ADRA2A PURINE CATABOLISM%REACTOME%R-HSA-74259.4 Purine catabolism DNPH1 NT5C NT5E NUDT16 NUDT15 NT5C1A NT5C1B ADPRM ITPA GDA NT5C2 XDH NUDT5 PNP PROCESSING OF INTRONLESS PRE-MRNAS%REACTOME DATABASE ID RELEASE 76%77595 Processing of Intronless Pre-mRNAs NCBP2 CSTF2T CSTF1 FIP1L1 SYMPK CSTF2 PABPN1 PAPOLA CPSF1 CPSF4 PCF11 CPSF7 WDR33 CPSF3 CSTF3 NUDT21 NCBP1 CPSF2 CLP1 METABOLISM OF INGESTED MESEO2H INTO MESEH%REACTOME%R-HSA-5263617.2 Metabolism of ingested MeSeO2H into MeSeH TXNRD1 PTK6 PROMOTES HIF1A STABILIZATION%REACTOME DATABASE ID RELEASE 76%8857538 PTK6 promotes HIF1A stabilization LRRK2 PTK6 HBEGF EGFR HIF1A GPNMB INTEGRATION OF PROVIRUS%REACTOME%R-HSA-162592.2 Integration of provirus BANF1 rev gag-pol vif PPIA vpr PSIP1 vpu gag XRCC4 XRCC6 XRCC5 LIG4 HMGA1 KPNA1 DEFECTIVE PRO-SFTPB CAUSES SMDP1 AND RDS%REACTOME%R-HSA-5688031.2 Defective pro-SFTPB causes SMDP1 and RDS SFTPB ASYMMETRIC LOCALIZATION OF PCP PROTEINS%REACTOME DATABASE ID RELEASE 76%4608870 Asymmetric localization of PCP proteins FZD8 FZD7 FZD3 SMURF2 FZD5 FZD4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PRICKLE1 PSMA6 PSMA3 FZD1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 SCRIB UBC PSMB8 PSMB9 WNT5A RPS27A SEM1 PSMC5 PSMC6 VANGL2 PSMC3 PSMC4 PSMC1 PSMC2 SMURF1 DVL2 PARD6A POU5F1 (OCT4), SOX2, NANOG REPRESS GENES RELATED TO DIFFERENTIATION%REACTOME%R-HSA-2892245.1 POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation SOX2 NANOG POU5F1 RAF MAP KINASE CASCADE%REACTOME%R-HSA-5673001.10 RAF MAP kinase cascade BRAP CSF2 FN1 BRAF DUSP16 DUSP8 DUSP9 VCL CNKSR2 APBB1IP CNKSR1 MRAS KIT FYN MAPK1 SHOC2 MAPK3 PDGFB PEBP1 ARRB1 PDGFRB IL2 ARRB2 HGF IL3 ERBB2 MARK3 PPP1CB PPP2R1A DUSP10 KSR1 KSR2 SPTB PIK3R2 RET ITGA2B UBA52 MAP2K1 MAP2K2 SHC3 UBB UBC PTPRA RPS27A ITGB3 JAK2 PDE6D MET EREG BTC SRC GOLGA7 SPTBN4 SPTBN5 TGFA FLT3 KRAS TLN1 SPTBN2 ACTN2 RASGRF2 RASGRF1 GRIN2B GRIN1 GRIN2D DLG1 DLG2 DLG3 ARTN LRRC7 DLG4 NEFL GFRA1 GFRA3 GFRA2 GFRA4 RANBP9 NRTN JAK1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSPN BCL2L1 FGB PSMD1 FGA PSMA5 PSMA6 VWF PSMA3 GDNF PSMA4 PSMA1 PSMA2 EPGN FGG PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 NCAM1 PSMB6 PSMB7 PSMB4 PSMB5 MAPK12 PSMB2 PSMB3 KLB PSMB1 IRS1 PHB PSMF1 PSMB8 IRS2 PSMB9 PIK3CB FGF1 SEM1 PSMC5 FGF2 PSMC6 FGF3 PSMC3 FGF4 PSMC4 FGF6 RASGRP1 PSMC1 FGF7 PSMC2 FGF9 RAP1B RAP1A FGF20 RAF1 FGF23 FGF22 FLT3LG FRS2 SPTA1 FGF16 FGF19 FGF18 FGFR4 FGF10 PPP2R1B PPP2R5E PRKG2 FRS3 PPP2R5B RCE1 PPP2R5A PPP2R5D PPP2R5C ARL2 PPP2CA PPP2CB IL5RA CSF2RB IL2RG CSF2RA IL5 MAP3K11 IL2RB IL3RA USP17L2 PIK3R1 IQGAP1 CALM1 SPTAN1 SPTBN1 EGF YWHAB DUSP4 DUSP6 DUSP7 PTK2 CAMK2B CSK CAMK2D CAMK2A CAMK2G PPP1CC RASGRP4 PRKCQ SHC1 PIK3CA SOS1 RBX1 PPP5C SHC2 RALGDS AREG JAK3 NRG1 NRG2 NRG3 NRG4 CUL3 IL2RA RASGRP3 HBEGF EGFR ICMT ABHD17C ZDHHC9 ABHD17B SPRED3 ABHD17A FNTB SPRED2 SPRED1 SYNGAP1 HRAS PDGFRA RASA3 RASA4 RASA1 RASA2 RASAL1 WDR83 RASAL2 PAQR3 RASAL3 RGL3 NRAS LAMTOR2 RGL1 DAB2IP RGL2 NF1 PEA15 KBTBD7 LAMTOR3 DUSP5 DUSP2 DUSP1 FNTA ARAF IL17RD RAPGEF2 RASGEF1A ANGPT1 TEK PTPN7 LYPLA1 PTPN3 RNA POLYMERASE I TRANSCRIPTION TERMINATION%REACTOME DATABASE ID RELEASE 76%73863 RNA Polymerase I Transcription Termination POLR1H TAF1D TAF1B TAF1C TAF1A CAVIN1 CCNH POLR2E POLR2F POLR2H POLR2K POLR2L GTF2H1 TTF1 GTF2H2 GTF2H3 GTF2H4 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 UBTF POLR1A POLR1B POLR1C POLR1D POLR1E POLR1F POLR1G RESPONSE OF EIF2AK4 (GCN2) TO AMINO ACID DEFICIENCY%REACTOME DATABASE ID RELEASE 76%9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency CEBPB CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 RPL4 RPL5 RPL30 ATF3 RPL3 ATF4 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA EIF2AK4 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A ATF2 IMPACT RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 GCN1 RPS24 RPS23 ASNS RIBOSOMAL SCANNING AND START CODON RECOGNITION%REACTOME%R-HSA-72702.3 Ribosomal scanning and start codon recognition EIF5 RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 FAU RPS21 RPS24 RPS23 EIF4H EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 RPS4X RPS15 EIF4A1 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF4E EIF4B RPS8 RPS5 RPS6 RPSA RPS3A RPS27A RPS4Y2 RPS27L RPS4Y1 EIF4G1 RPS15A RPS3 RPS2 CLEC7A INFLAMMASOME PATHWAY%REACTOME DATABASE ID RELEASE 76%5660668 CLEC7A inflammasome pathway PYCARD RELA IL1B NFKB1 CASP8 MALT1 COHESIN LOADING ONTO CHROMATIN%REACTOME DATABASE ID RELEASE 76%2470946 Cohesin Loading onto Chromatin STAG1 STAG2 MAU2 SMC3 NIPBL PDS5B PDS5A SMC1A WAPL RAD21 DEFECTIVE MMACHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLC%REACTOME%R-HSA-3359474.1 Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC MMACHC DEFECTIVE GCLC CAUSES HAGGSD%REACTOME DATABASE ID RELEASE 76%5578999 Defective GCLC causes HAGGSD GCLC GCLM HYALURONAN METABOLISM%REACTOME%R-HSA-2142845.1 Hyaluronan metabolism HAS2 CHP1 HMMR CD44 GUSB HEXB SLC9A1 CEMIP HEXA HYAL1 STAB2 LYVE1 HYAL3 HAS1 HYAL2 ABCC5 HAS3 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME%R-HSA-5619081.1 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 GLUCOSE METABOLISM%REACTOME%R-HSA-70326.8 Glucose metabolism FBP1 PPP2R1B SLC25A11 GPI FBP2 PCK2 NUP42 SLC37A1 NUP43 MDH1 RAE1 MDH2 RANBP2 G6PC2 ENO1 ALDOB PRKACG PRKACB GCK NUP35 PPP2R5D NUP37 PGK1 GAPDHS PPP2CA PPP2CB ALDOC ALDOA SEC13 PPP2R1A G6PC3 PRKACA PCK1 NUP107 NUP188 ADPGK G6PC1 ENO2 ENO3 PGAM1 HK2 TPI1 PGAM2 BPGM PGM2L1 PGP GAPDH PFKFB2 PFKFB1 NUP210 PFKFB4 PFKFB3 PGK2 NUP93 GNPDA1 GNPDA2 PFKM POM121 GOT1 PFKP NUP205 GOT2 AAAS NUP160 POM121C NUP85 TPR NUP88 GCKR HK3 NUP155 PC NUP214 NUP153 SLC25A1 HK1 SLC37A4 NUP62 NDC1 SLC25A10 SLC25A12 NUP133 PFKL SLC25A13 NUP50 NUP54 EICOSANOID LIGAND-BINDING RECEPTORS%REACTOME%R-HSA-391903.1 Eicosanoid ligand-binding receptors PTGDR2 OXER1 PTGDR PTGIR PTGER4 GPR17 TBXA2R CYSLTR1 CYSLTR2 PTGFR PTGER1 PTGER2 PTGER3 LTB4R2 LTB4R GTP HYDROLYSIS AND JOINING OF THE 60S RIBOSOMAL SUBUNIT%REACTOME%R-HSA-72706.2 GTP hydrolysis and joining of the 60S ribosomal subunit EIF2S2 EIF2S1 EIF2S3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A EIF5 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF5B EIF4H EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 EIF4A1 EIF4E EIF4B GSD 0%REACTOME DATABASE ID RELEASE 76%3858516 GSD 0 GYS2 GYG2 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX%REACTOME DATABASE ID RELEASE 76%937042 IRAK2 mediated activation of TAK1 complex TAB1 UBB UBA52 UBC IRAK2 RPS27A TRAF6 TAB3 TAB2 MAP3K7 DEFECTIVE GGT1 CAUSES GLUTH%REACTOME%R-HSA-5579022.3 Defective GGT1 causes GLUTH GGT1 REVERSAL OF ALKYLATION DAMAGE BY DNA DIOXYGENASES%REACTOME%R-HSA-73943.2 Reversal of alkylation damage by DNA dioxygenases ALKBH3 ASCC1 ASCC2 ASCC3 FTO ALKBH2 ALKBH5 PHASE 2 - PLATEAU PHASE%REACTOME DATABASE ID RELEASE 76%5576893 Phase 2 - plateau phase KCNQ1 CACNG8 CACNG4 CACNG6 CACNG7 AKAP9 KCNE1 KCNE2 KCNE3 KCNE4 CACNB1 KCNE5 CACNA2D2 CACNB2 CACNA1C CAMK IV-MEDIATED PHOSPHORYLATION OF CREB%REACTOME%R-HSA-111932.3 CaMK IV-mediated phosphorylation of CREB CAMK4 CAMK2B CAMKK1 CAMK2D CAMKK2 CAMK2A KPNA2 CALM1 CAMK2G CREB1 ACTIVATION OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 76%399710 Activation of AMPA receptors GRIA3 GRIA4 GRIA1 GRIA2 PEPTIDE CHAIN ELONGATION%REACTOME%R-HSA-156902.2 Peptide chain elongation RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 EEF1A1 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L EEF2 RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 REGULATED PROTEOLYSIS OF P75NTR%REACTOME%R-HSA-193692.1 Regulated proteolysis of p75NTR PSEN1 PSENEN NCSTN ADAM17 RELA NFKB1 PSEN2 TRAF6 APH1A NGFR APH1B SIGNALING BY MRAS-COMPLEX MUTANTS%REACTOME%R-HSA-9660537.1 Signaling by MRAS-complex mutants RAF1 ARAF MRAS BRAF YWHAB SHOC2 PPP1CC PPP1CB NEGATIVE REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 76%5675221 Negative regulation of MAPK pathway BRAP PPP2R1B PPP2R5E BRAF DUSP16 PPP2R5B PPP2R5A DUSP8 PPP2R5D DUSP9 PPP2R5C UBA52 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 DUSP4 PEBP1 PPP2CA MAPK12 DUSP6 PPP2CB UBB DUSP7 HRAS UBC MARK3 RPS27A PAQR3 PPP5C NRAS DUSP10 PPP2R1A DUSP5 RAF1 DUSP2 KSR1 DUSP1 ARAF PTPN7 PTPN3 DISEASES ASSOCIATED WITH N-GLYCOSYLATION OF PROTEINS%REACTOME%R-HSA-3781860.1 Diseases associated with N-glycosylation of proteins DPAGT1 MGAT2 MOGS MPDU1 RFT1 MAN1B1 ALG2 B4GALT1 ALG14 ALG13 ALG12 ALG8 ALG11 ALG9 ALG6 ALG3 ALG1 ACTIVATION OF THE AP-1 FAMILY OF TRANSCRIPTION FACTORS%REACTOME%R-HSA-450341.1 Activation of the AP-1 family of transcription factors JUN MAPK14 MAPK11 MAPK1 MAPK9 ATF2 MAPK10 MAPK8 MAPK3 FOS SARS-COV-2 INFECTION%REACTOME%R-HSA-9694516.2 SARS-CoV-2 Infection ACE2 TMPRSS2 ST3GAL3 7a 3a GSK3A SUMO1 CHMP2B CHMP2A ST6GALNAC2 RPN2 PRKCSH CTSL TUSC3 RPN1 MAGT1 FUT8 GANAB S MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MAP1LC3B MOGS M DDOST MGAT4C DAD1 MGAT4A CHMP3 MGAT4B CANX STT3A MAN1B1 CHMP6 ST6GALNAC3 CHMP7 ST6GALNAC4 FURIN ZCRB1 DDX5 VHL 9b UVRAG VCP GALNT1 PARP10 PARP6 GSK3B PARP4 PARP16 PARP9 UBA52 PARP14 N PARP8 BECN1 E rep UBB RB1 PIK3R4 UBC RPS27A CHMP4C CHMP4B CHMP4A PIK3C3 UBE2I SIGNALING BY NOTCH2%REACTOME DATABASE ID RELEASE 76%1980145 Signaling by NOTCH2 PSEN1 HES1 PSENEN JAG2 NEURL1 NCSTN MDK CNTN1 MAMLD1 FCER2 JAG1 UBA52 NOTCH2 NEURL1B MIB2 MIB1 UBB GZMB UBC EP300 RPS27A PSEN2 MAML2 APH1A MAML1 RBPJ APH1B CREB1 ADAM10 MAML3 DLL1 DLL4 HES5 DEFECTIVE SLC2A1 CAUSES GLUT1 DEFICIENCY SYNDROME 1 (GLUT1DS1)%REACTOME DATABASE ID RELEASE 76%5619043 Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1) SLC2A1 THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS (PARS)%REACTOME%R-HSA-456926.2 Thrombin signalling through proteinase activated receptors (PARs) GNA14 F2RL2 F2 F2RL3 GNG3 GNA15 GNG2 GNA13 GNG5 GNG4 GNG7 GNA11 GNG8 MAPK1 GNA12 F2R GNG10 MAPK3 ARRB1 GNG12 ARRB2 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 GPCR DOWNSTREAM SIGNALLING%REACTOME DATABASE ID RELEASE 76%388396 GPCR downstream signalling PLCB3 GPR15 PLCB1 PRKCB PLCB2 PPP3R1 GPR27 GPR25 GPR20 ADM PTH1R GPR32 PTH2R MAPK1 RAMP2 RAMP3 MAPK3 GPR45 PTH GNAI3 PRKX GNAI1 GNAI2 GPR150 SCTR PPP2R1A GCG GHRH ADM2 RAMP1 PRKACA IAPP PRKCG GNAZ CALCA CALCB CALCRL GPR83 GPR84 CALCR CDK5 GLP1R PRKAR2B GLP2R GIP CRH PTH2 PTHLH VIP CAMKK1 RASGRF2 CAMKK2 NBEA PRKCE PPP3CC RASGRP2 RASGRP1 GNAL RGS9 RGS6 RGS7 NPFFR2 APP OXTR MCF2L NPFFR1 VAV3 RXFP4 RRH ARHGEF16 HTR4 GRPR VAV1 RXFP1 RXFP2 GNG10 RXFP3 ARHGEF5 EDNRA ARHGEF26 HTR6 EDNRB HTR7 GNG12 C3AR1 KALRN GNG11 OXER1 GNG13 PROK2 PROK1 GNB2 PTGDR GNAQ GNB1 UTS2R TAAR8 GNB4 TAAR9 TAAR6 GNB3 NPFF TAAR5 TAAR2 GNB5 GPR37L1 PDYN TAAR1 TRHR GNGT1 UTS2B AGTR1 GNGT2 AGTR2 PTGFR LHB LPAR1 FPR1 LPAR2 LPAR3 FPR3 LPAR4 FPR2 C3 MC2R C5 GALR3 GALR2 GNA14 GALR1 NPBWR1 PENK GNG3 NPBWR2 GNA15 PPY HCRT GNG2 CGA CCR10 GNG5 NTSR1 GNG4 NTSR2 GNG7 CCR1 GNA11 GPR17 GNG8 NMB XCR1 PPBP NMBR MC1R LPAR5 LPAR6 RGS11 NMS GPR183 PNOC NMU GNRH2 GNRH1 GPR18 PTGDR2 QRFP PLEKHG5 CX3CL1 MLN BRS3 MC4R GPR132 CCKAR OPN1LW CCR9 FFAR4 GNRHR CCR8 FFAR3 CCR7 FFAR2 FFAR1 CCR6 CCR5 CCR4 PPP1CA CCR3 OXGR1 CCR2 GPR39 ITSN1 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B AKT3 FSHB TACR2 GPBAR1 GPR31 MGLL TACR3 AVPR1A TACR1 F2 MC3R GAL PIK3CA ADRB3 CCKBR OPN1MW SOS1 FSHR AVP RGR PTGER4 NPSR1 OPRD1 CCL13 NPB GRP PTGER1 PTGER2 PTAFR PTGER3 ARHGEF25 CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R RHO CCL19 GPHA2 CCL16 CCL25 P2RY12 P2RY13 P2RY10 P2RY11 CCL21 CCL20 P2RY14 GPR55 GPR4 AGT GPR143 MT-RNR2 MC5R SAA1 F2RL1 CCL28 CCL27 F2RL2 PF4 F2RL3 GPHB5 CHRM2 CHRM3 CHRM1 GPR68 CHRM4 GPR65 NPY2R CHRM5 PMCH CXCL13 HBEGF CXCL16 CYSLTR1 CYSLTR2 ADORA3 EGFR ADORA1 AKT2 GHSR LHCGR F2R NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 C5AR1 ADRB1 ADRB2 NTS MCHR1 MCHR2 KNG1 HCAR2 HCAR3 TAAR3P HRH1 HCAR1 TBXA2R HRH2 PSAP HRH4 TAC3 DRD1 TAC1 DRD3 DRD4 DRD5 OPN4 OPN3 HTR1E HTR1F HTR1D HTR1B OPN5 CXCL10 PYY CXCL11 KPNA2 CXCL12 RLN2 RLN3 NMUR2 NMUR1 GNA13 CXCL6 CXCL9 GNAT1 CXCL8 GAST MLNR PLCB4 HTR2B TRIO HTR2C RGSL1 PPP1R1B OXT PDE3A ADRA1D CCL4L2 RGS4 CXCL1 HTR2A RGS5 RPS6KA3 RGS2 TRH RGS3 RPS6KA2 RGS1 CXCL3 ADRA1B RPS6KA1 PDE8B RGS8 CXCL2 ADRA1A PDE8A PCP2 CXCL5 PREX1 GRK5 LTB4R GRK6 HEBP1 ARRB1 GPSM1 GPER1 ARRB2 GPSM2 BDKRB2 PDE4B PDE4A BDKRB1 INSL3 GPSM3 QRFPR PDE4D INSL5 PDE4C TSHB RGS18 PTGIR RGS17 NPY5R RGS19 GNRHR2 RGS14 AVPR2 RGS13 OPRM1 RGS16 SSTR1 RGS21 SSTR2 RGS20 ADRA2C RGS22 SSTR3 RGS10 ADRA2B VAV2 RGS12 SSTR4 PDE7B ADRA2A TIAM1 PDE7A SSTR5 CORT ADORA2A ADORA2B XCL2 XCL1 CX3CR1 NPY4R PIK3R2 OPRL1 P2RY6 CNR2 P2RY4 ABR CNR1 CCL5 P2RY2 CCL4 P2RY1 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HTR5A HCRTR2 MCF2 TSHR APLN HCRTR1 KISS1 POMC OPN1SW SST ACKR3 SRC ARHGEF40 TIAM2 OBSCN NGEF MMP3 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 PDE3B GRK3 GRK2 PPP2R1B TRPC7 TRPC6 TRPC3 PLA2G4A PPP2R5D PDE1B PDE1A ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PDE11A PDE2A PDPK1 PIK3R1 PDE10A CDC42 PAK1 CALM1 ADCYAP1 ADCYAP1R1 ARHGEF7 AKT1 PRKCD PRKCA MAPK7 CAMK2B CAMK2D CAMK2A CAMK2G DGKG DGKE DAGLA DGKD CREB1 DGKB DGKA CAMK4 ABHD6 ABHD12 PRKCH DGKZ DGKQ PRKCQ DAGLB DGKK DGKI DGKH PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A BTK RHOC RHOB GNA12 PLXNB1 PRKAR2A GNAS PDE1C PIK3R6 ADCY4 PIK3CG PIK3R5 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 TAS2R60 TAS2R7 TAS2R9 TAS2R40 TAS2R8 TAS2R41 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM1 GRM3 GPRC6A GRM2 GRM5 GRM4 ROCK1 GRM7 ROCK2 GRM6 GRM8 TAS1R2 TAS2R1 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 VIPR1 GABBR2 VIPR2 CASR AHCYL1 GABBR1 SCT TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR176 TAS2R38 TAS2R39 GNAT3 TAS2R19 HRAS NRAS PIK3R3 ARHGEF18 GIPR RHOA CRHR1 CRHR2 PPP3CA GHRHR PPP3CB GNAT2 DEFECTIVE SLC3A1 CAUSES CYSTINURIA (CSNU)%REACTOME%R-HSA-5619113.1 Defective SLC3A1 causes cystinuria (CSNU) SLC3A1 SLC7A9 INFLUENZA INFECTION%REACTOME%R-HSA-168255.4 Influenza Infection PABPN1 KPNA7 KPNA4 NUP42 KPNA5 NUP43 KPNA2 RAE1 KPNA3 RANBP2 CPSF4 EIF2AK2 RAN NUP35 NUP37 KPNA1 HSP90AA1 KPNB1 CANX CLTC RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 SLC25A6 RPS10 RPS13 RPS12 CALR RPS9 XPO1 RPS7 IPO5 RPL21 NUP214 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 PARP1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A HSPA1A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PA PB2 GTF2F1 NP NA NS GTF2F2 HA M PB1 CLTA SEC13 ISG15 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 DNAJC3 NUP62 NDC1 TGFB1 NUP133 GRSF1 NUP50 NUP54 SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE%REACTOME%R-HSA-1660499.6 Synthesis of PIPs at the plasma membrane RAB4A PIK3CA SYNJ2 SYNJ1 PIP5K1C INPPL1 PIK3C2A RAB5A PIK3R6 PIK3CG PIK3R5 ARF1 OCRL PI4K2B RUFY1 PIK3R1 MTMR2 MTMR8 MTMR9 MTMR6 PIK3R2 INPP5J INPP5K PTEN PLEKHA1 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 MTM1 PLEKHA4 RAB14 INPP4A PLEKHA8 INPP4B PI4K2A PIP5K1A PIP5K1B INPP5D SBF2 PIK3C2G PIK3C2B PTPN13 PIK3CB MTMR3 PIK3CD MTMR14 PIK3R3 BMX PIP4K2A PIP4K2B PIP4K2C MTMR1 UBIQUITIN MEDIATED DEGRADATION OF PHOSPHORYLATED CDC25A%REACTOME%R-HSA-69601.3 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A CHEK1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHEK2 ELECTRIC TRANSMISSION ACROSS GAP JUNCTIONS%REACTOME DATABASE ID RELEASE 76%112303 Electric Transmission Across Gap Junctions GJC1 GJD2 PANX2 PANX1 GJA10 ERYTHROPOIETIN ACTIVATES PHOSPHOLIPASE C GAMMA (PLCG)%REACTOME DATABASE ID RELEASE 76%9027277 Erythropoietin activates Phospholipase C gamma (PLCG) JAK2 EPOR IRS2 PLCG1 LYN EPO PLCG2 NONSENSE-MEDIATED DECAY (NMD)%REACTOME DATABASE ID RELEASE 76%927802 Nonsense-Mediated Decay (NMD) PPP2CA PPP2R1A RPL4 RPL5 RPL30 RPL3 RPL32 PPP2R2A RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 UPF3A RPS4X RPS15 RPL7A RPS14 RPS17 UPF2 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 UPF1 RPS9 RPS7 RPL21 NCBP1 RPS8 SMG1 SMG9 NCBP2 RPS5 SMG7 RPL23 SMG8 RPL22 SMG5 RPS6 SMG6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 DCP1A GSPT1 EIF4G1 RPS15A PNRC2 RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU EIF4A3 RPS21 CASC3 RPL26L1 RPS24 MAGOH RPS23 RBM8A UPF3B MAGOHB RNPS1 GALACTOSE CATABOLISM%REACTOME DATABASE ID RELEASE 76%70370 Galactose catabolism PGM2L1 GALK1 GALT GALE PGM2 OLEOYL-PHE METABOLISM%REACTOME%R-HSA-9673163.1 Oleoyl-phe metabolism PM20D1 GENE AND PROTEIN EXPRESSION BY JAK-STAT SIGNALING AFTER INTERLEUKIN-12 STIMULATION%REACTOME%R-HSA-8950505.3 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RPLP0 MIF ANXA2 PPIA CNN2 STAT4 AIP IL10 PSME2 HSPA9 MTAP CAPZA1 CFL1 GSTO1 PAK2 SOD2 LMNB1 SERPINB2 HNRNPF LCP1 BOLA2B HNRNPDL ARF1 RAP1B MSN SOD1 PDCD4 CDC42 RALA TALDO1 CA1 IFNG SNRPA1 TCP1 PITPNA GSTA2 HNRNPA2B1 HIGHLY CALCIUM PERMEABLE NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME DATABASE ID RELEASE 76%629597 Highly calcium permeable nicotinic acetylcholine receptors CHRNA6 CHRNB4 CHRNB2 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 RHO GTPASES ACTIVATE PAKS%REACTOME DATABASE ID RELEASE 76%5627123 RHO GTPases activate PAKs LIMK1 MYL6 MYH14 MYH11 MYL9 MYH10 MYLK PAK2 PPP1CB FLNA MYH9 RAC1 NF2 CTTN MYL12B CDC42 PAK3 PAK1 CALM1 PPP1R12A PPP1R12B ANTIGEN PRESENTATION: FOLDING, ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC%REACTOME%R-HSA-983170.3 Antigen Presentation: Folding, assembly and peptide loading of class I MHC ERAP2 ERAP1 B2M SEC24B HLA-A SEC24A TAP2 SAR1B SEC31A TAP1 HSPA5 PDIA3 TAPBP CALR SEC24D SEC24C HLA-H HLA-B HLA-C HLA-F HLA-G HLA-E SEC13 CANX SEC23A TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION%REACTOME%R-HSA-948021.2 Transport to the Golgi and subsequent modification COL7A1 TRAPPC2 ANKRD28 TRAPPC3 SEC16B F8 TRAPPC1 TRAPPC4 SEC16A TRAPPC5 TMEM115 COPE TRAPPC9 CNIH1 MAN1A2 MAN1A1 FUT8 CNIH2 CNIH3 MAN2A1 MCFD2 MGAT5 ST3GAL4 MGAT1 TRAPPC6A MGAT2 ST6GAL1 PPP6C PPP6R1 TRAPPC6B PPP6R3 GORASP1 MGAT4C FUCA1 MGAT4A ACTR1A MGAT4B ARFGAP3 SPTB DCTN6 ARFGAP1 DCTN5 CHST10 BET1L LHB CHST8 ARFGAP2 DCTN1 GOSR2 SEC22B DCTN4 SEC22A GOSR1 FUT3 SPTAN1 SEC22C DYNLL2 RAB1A SPTBN1 SEC23A INS RAB1B LMAN1 CSNK1D MAN1C1 DYNLL1 CGA YKT6 SEC24B SEC24A DYNC1I2 DCTN2 SEC24D DCTN3 SEC24C FOLR1 BET1 KDELR1 GOLGA2 CAPZB COG8 COG7 COG6 DYNC1H1 LMAN1L COG5 COG4 COG3 MANEA COG2 COG1 B4GALT1 ANK2 ANK3 ANK1 TFG PREB KDELR2 KDELR3 SPTBN4 SPTBN5 LMAN2L TGFA SCFD1 DYNC1LI1 DYNC1LI2 SEC31A SPTBN2 CAPZA1 CAPZA2 CTSZ MIA2 MIA3 ARF3 TMED3 B4GALT2 TMED2 ARF4 B4GALT3 TMED7 ARF1 CTSC SERPINA1 SEC13 ST8SIA6 TMED9 B4GALT6 B4GALT4 ST8SIA2 AREG B4GALT5 NAPA ST8SIA3 NAPB STX17 COPZ2 NAPG COPZ1 CD59 DYNC1I1 CD55 GBF1 SEC23IP SAR1B CAPZA3 ARF5 F5 COPG2 COPG1 USO1 ACTR10 LMAN2 MGAT3 STX5 TRAPPC10 ARCN1 NSF TRAPPC2L TBC1D20 COPB2 COPA TMED10 GRIA1 COPB1 SPTA1 MAN2A2 HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR) OR SINGLE STRAND ANNEALING (SSA)%REACTOME%R-HSA-5693567.2 HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) RHNO1 BLM BRIP1 ATRIP BRCC3 BARD1 RAD17 RAD9B ATR RAD9A BABAM1 BABAM2 BRCA1 UIMC1 EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 RMI1 TOP3A WRN RBBP8 RPA1 H3-4 RPA2 RAD50 PPP4R2 TIPIN RPA3 TIMELESS PPP4C RAD1 POLH CLSPN ABL1 HERC2 TP53BP1 UBA52 RNF168 ABRAXAS1 UBB RTEL1 RAD52 UBC POLK POLE RPS27A BRCA2 RAD51AP1 XRCC2 RFC1 XRCC3 PALB2 RAD51D RAD51 MDC1 UBE2V2 SIRT6 PIAS4 RAD51B POLD3 RAD51C UBE2I POLD4 CCNA2 POLD1 CCNA1 POLD2 RNF4 POLE4 ERCC4 ERCC1 CDK2 POLE2 POLE3 ATM SUMO1 SUMO2 PCNA H2AX RNF8 NSD2 MUS81 H2BC21 SLX4 EME1 H2BU1 EME2 GEN1 SLX1B SPIDR H2BC17 H2BC12 H2BC13 CHEK1 H2BC14 H2BC15 H2BC11 H2BS1 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 MRE11 KAT5 NBN HUS1 UBE2N DNA2 PLATELET DEGRANULATION%REACTOME DATABASE ID RELEASE 76%114608 Platelet degranulation FN1 ACTN1 LEFTY2 F8 BRPF3 VCL APP PECAM1 THBS1 GAS6 PDGFB CYB5R1 HGF A1BG FLNA SOD1 SERPINA3 CALM1 ABCC4 POTEKP ISLR HABP4 FAM3C CHID1 SERPINF2 ACTN4 GTPBP2 SYTL4 TMX3 CD109 SELENOP TAGLN2 NHLRC2 TEX264 EGF TUBA4A STXBP2 ENDOD1 APOH VTI1B ITGA2B RARRES2 CYRIB LAMP2 MANF PPBP SELP SCCPDH MAGED2 HRG FERMT3 LGALS3BP ECM1 WDR1 PLEK CFL1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 PHACTR2 SRGN ANXA5 VEGFB MMRN1 TOR4A PCDH7 VEGFC ITIH4 VEGFD ITIH3 CLEC3B VEGFA CDC37L1 LY6G6F LHFPL2 PCYOX1L ITGB3 SERPINE1 TGFB2 TGFB3 A2M TTN TLN1 PFN1 ACTN2 HSPA5 ORM1 RAB27B ORM2 CD36 TF TIMP1 CAP1 ALDOA SERPINA1 CD63 IGF1 IGF2 PLG PROS1 F13A1 APOA1 FGB PF4 FGA APLP2 PPIA VWF SCG3 FGG CLU F5 CD9 APOOL SERPING1 CALU QSOX1 AHSG ALB KNG1 CFD SPARC TGFB1 PSAP SPP2 ALPK1 SIGNALING PATHWAY%REACTOME%R-HSA-9645460.2 ALPK1 signaling pathway TAB1 UBB UBA52 UBC RPS27A TRAF6 TIFA TAB3 TAB2 ALPK1 MAP3K7 FLT3 MUTANTS BIND TKIS%REACTOME DATABASE ID RELEASE 76%9702509 FLT3 mutants bind TKIs FLT3 FREE FATTY ACID RECEPTORS%REACTOME DATABASE ID RELEASE 76%444209 Free fatty acid receptors FFAR1 GPR31 FFAR4 FFAR3 FFAR2 GABA SYNTHESIS, RELEASE, REUPTAKE AND DEGRADATION%REACTOME DATABASE ID RELEASE 76%888590 GABA synthesis, release, reuptake and degradation SNAP25 SYT1 HSPA8 RAB3A CPLX1 RIMS1 ALDH5A1 STX1A SLC6A12 VAMP2 SLC32A1 SLC6A11 ABAT DNAJC5 GAD1 GAD2 SLC6A1 SLC6A13 DEFECTIVE LARGE CAUSES MDDGA6 AND MDDGB6%REACTOME%R-HSA-5083627.1 Defective LARGE causes MDDGA6 and MDDGB6 B4GAT1 LARGE1 G-PROTEIN MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 76%112040 G-protein mediated events PLCB3 PLCB1 GNAL PLCB2 KPNA2 PRKACG PRKACB PLA2G4A PLCB4 ADCY9 PRKAR1B CAMKK1 CAMKK2 PRKAR1A MAPK1 PDE1B PDE1A PRKAR2A ITPR1 ITPR2 ITPR3 GNAI3 PRKX GNAI1 GNAI2 NBEA GNAQ PDE1C ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACA CALM1 PRKCG GNA14 GNA15 GNA11 AHCYL1 PRKCD PRKCA CAMK2B PRKAR2B GNAT3 CAMK2D CAMK2A CAMK2G CREB1 CAMK4 GRK2 FORMATION OF THE CORNIFIED ENVELOPE%REACTOME%R-HSA-6809371.3 Formation of the cornified envelope IVL SPRR3 CSTA LCE2D LCE3C LCE3D LCE3A LCE3B PI3 KLK13 KLK14 LCE3E KLK12 PERP JUP LCE4A TGM1 TGM5 RPTN SPINK6 SPINK5 LCE1A KAZN LCE1B LIPJ LIPN LIPM PCSK6 PRSS8 LIPK PKP2 PKP3 DSG2 SPINK9 DSC2 DSC3 FURIN LCE1E LCE1F LCE1C LCE1D LELP1 LCE2B LCE2C LCE2A LORICRIN SPRR2E FLG SPRR2F TCHH SPRR2G KLK5 KLK8 CELA2A EVPL SPRR2A SPRR2B SPRR2D ST14 CDSN DSC1 SPRR1A SPRR1B DSP DSG4 CASP14 CAPNS1 LCE5A CAPN1 DSG1 PKP4 PKP1 DSG3 PPL LCE6A RHESUS BLOOD GROUP BIOSYNTHESIS%REACTOME%R-HSA-9037628.1 Rhesus blood group biosynthesis RHCE RHD CONJUGATION OF BENZOATE WITH GLYCINE%REACTOME%R-HSA-177135.1 Conjugation of benzoate with glycine ACSM1 ACSM2B GLYATL3 GLYAT GLYATL2 GLYATL1 REGULATION OF GENE EXPRESSION BY HYPOXIA-INDUCIBLE FACTOR%REACTOME DATABASE ID RELEASE 76%1234158 Regulation of gene expression by Hypoxia-inducible Factor CREBBP HIGD1A CITED2 HIF3A ARNT EP300 VEGFA EPAS1 HIF1A EPO CA9 RHO GTPASES ACTIVATE NADPH OXIDASES%REACTOME%R-HSA-5668599.6 RHO GTPases Activate NADPH Oxidases PRKCD PRKCA PRKCB PIK3R4 CYBB CYBA RAC2 RAC1 S100A9 NCF1 S100A8 NCF2 MAPK14 MAPK11 NCF4 MAPK1 PRKCZ PIN1 NOXO1 PIK3C3 NOXA1 MAPK3 NOX3 NOX1 TRANSPORT OF GAMMA-CARBOXYLATED PROTEIN PRECURSORS FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME%R-HSA-159763.3 Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus F7 PROC F2 F9 F10 BGLAP PROS1 PROZ GAS6 CERAMIDE SIGNALLING%REACTOME%R-HSA-193681.2 Ceramide signalling NGF SMPD2 NGFR VEGFR2 MEDIATED VASCULAR PERMEABILITY%REACTOME%R-HSA-5218920.2 VEGFR2 mediated vascular permeability MAPKAP1 CTNNA1 CDH5 CTNNB1 CAV1 JUP PRR5 PAK3 VAV3 AKT2 MLST8 VAV1 AKT1 HSP90AA1 MTOR PAK2 NOS3 PDPK1 CTNND1 THEM4 RICTOR RAC1 VAV2 PAK1 TRIB3 CALM1 AKT3 REGULATION OF PTEN MRNA TRANSLATION%REACTOME DATABASE ID RELEASE 76%8943723 Regulation of PTEN mRNA translation TNRC6A AGO3 TNRC6B PTEN AGO4 AGO1 AGO2 TNRC6C MOV10 DEFECTIVE F9 SECRETION%REACTOME DATABASE ID RELEASE 76%9673218 Defective F9 secretion F9 E3 UBIQUITIN LIGASES UBIQUITINATE TARGET PROTEINS%REACTOME DATABASE ID RELEASE 76%8866654 E3 ubiquitin ligases ubiquitinate target proteins DERL1 RTF1 LEO1 UBE2B RAD18 PAF1 UBE2L3 HLA-A RNF152 SHPRH PCNA RNF40 RNF144A SELENOS WAC BCL10 UBE2J2 HLTF TMEM129 UBE2A US11 RNF181 UBE2D2 UBE2D3 H2BC17 H2BC12 UBE2E1 H2BC13 UBE2D1 H2BC14 PEX2 H2BC15 H2BC11 VCP RNF20 PRKDC PEX10 H2BC9 PEX12 UBA52 PEX13 H2BC8 PEX14 H2BC5 H2BC3 H2BC1 HLA-B UBB RRAGA UBC RPS27A UBE2V2 CDC73 CTR9 UBE2N WDR61 TRANSCRIPTIONAL REGULATION BY THE AP-2 (TFAP2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 76%8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors CREBBP ESR1 YEATS4 TGFA KDM5B SUMO1 CGA MYBL2 TFAP2A TFAP2B TFAP2C CGB8 ATAD2 YY1 KIT APOE EGFR NPM1 DEK TFAP2D TFAP2E ERBB2 EP300 VEGFA KCTD15 CITED2 MYC CITED1 CITED4 WWOX CDKN1A NOP2 HSPD1 KCTD1 PITX2 UBE2I MITOCHONDRIAL TRANSLATION TERMINATION%REACTOME%R-HSA-5419276.1 Mitochondrial translation termination GFM2 MRRF MRPS17 MRPS15 MTRF1L MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPS18B MRPL49 MRPS18A MRPS2 MRPS21 MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 FRUCTOSE CATABOLISM%REACTOME%R-HSA-70350.6 Fructose catabolism KHK GLYCTK TKFC ALDH1A1 ALDOB MACROAUTOPHAGY%REACTOME%R-HSA-1632852.8 Macroautophagy TOMM22 ATG7 NBR1 UBE2V1 CSNK2A1 CHMP2B CHMP2A CSNK2A2 CSNK2B TOMM70 PRKN HSP90AA1 HSPA8 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG2 PLIN2 PRKAB1 PRKAG3 CHMP3 CHMP6 CHMP7 TOMM20 DYNLL2 HSF1 TOMM40 HDAC6 PARK7 UVRAG DYNLL1 USP30 UBA52 BECN1 DYNC1I2 TOMM7 TOMM5 TOMM6 UBB UBC RPS27A PCNT DYNC1H1 ARL13B ULK1 CFTR GABARAPL2 MFN1 ATM MFN2 DYNC1LI1 DYNC1LI2 IFT88 GABARAP WIPI1 SQSTM1 MAP1LC3B ATG5 ATG12 PINK1 VDAC1 DYNC1I1 VCP EPAS1 PRKAA1 RPTOR MLST8 SLC38A9 TSC2 TSC1 GABARAPL3 MTOR ATG3 GABARAPL1 RRAGA PIK3R4 ATG9B ATG9A RRAGC ATG10 RHEB ATG14 RRAGB ATG13 RRAGD CHMP4C CHMP4B MTMR3 LAMTOR2 ATG101 LAMTOR1 MTERF3 LAMTOR4 CHMP4A LAMTOR3 ATG16L1 LAMTOR5 CETN1 MTMR14 WDR45 MAP1LC3A MAP1LC3C RB1CC1 FUNDC1 WIPI2 PEX5 ATG4C ATG4B PIK3C3 ATG4A UBE2N ATG4D WDR45B AMBRA1 SRP-DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE%REACTOME DATABASE ID RELEASE 76%1799339 SRP-dependent cotranslational protein targeting to membrane SEC61A2 SEC61A1 SEC61G SEC61B RPN2 RPN1 DDOST RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L TRAM1 RPS26 RPS25 SRP54 RPS28 RPS27 SSR4 RPS29 SSR2 RPL27A SSR3 SRP9 RPL22L1 RPS20 SRP72 FAU RPS21 SRP68 SPCS3 SRP19 SPCS2 RPL26L1 RPS24 SPCS1 RPS23 SEC11A SEC11C SSR1 SRPRA SRPRB SRP14 MITOTIC METAPHASE ANAPHASE TRANSITION%REACTOME%R-HSA-68881.2 Mitotic Metaphase Anaphase Transition PLK1 FBXO5 SENSING OF DNA DOUBLE STRAND BREAKS%REACTOME%R-HSA-5693548.1 Sensing of DNA Double Strand Breaks MRE11 KAT5 RAD50 NBN KPNA2 ATM SCN4%REACTOME%R-HSA-3282872.2 SCN4 G6PC3 INTERLEUKIN-2 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 76%451927 Interleukin-2 family signaling CSF2 SHC1 GRB2 PIK3CA SOS1 STAT4 PTK2B LCK IL2RA SOS2 SYK IL9 IL9R STAT3 INPP5D INPPL1 IL5RA STAT5A IL2 CSF2RB STAT5B STAT1 IL3 IL2RG CSF2RA IL5 PIK3CB IL2RB IL3RA PIK3CD PIK3R1 IL21 JAK2 PIK3R3 IL21R LGALS9 JAK3 HAVCR2 GAB2 IL15RA IL15 PTPN6 JAK1 PIK3R2 PHASE 4 - RESTING MEMBRANE POTENTIAL%REACTOME%R-HSA-5576886.1 Phase 4 - resting membrane potential KCNK5 KCNK13 KCNK16 KCNK17 KCNJ2 KCNJ4 KCNK6 KCNK18 KCNK7 KCNJ12 KCNK12 KCNK9 KCNJ14 KCNK15 KCNK1 KCNK2 KCNK3 KCNK4 KCNK10 IRAK1 RECRUITS IKK COMPLEX%REACTOME%R-HSA-937039.1 IRAK1 recruits IKK complex UBE2V1 IKBKB CHUK IRAK1 PELI3 PELI2 IKBKG TRAF6 UBE2N PELI1 SIGNALING BY EGFR IN CANCER%REACTOME DATABASE ID RELEASE 76%1643713 Signaling by EGFR in Cancer UBB HSP90AA1 CDC37 HRAS UBC SHC1 GAB1 TGFA RPS27A PIK3CA PLCG1 SOS1 EGF NRAS EPGN PIK3R1 UBA52 HBEGF AREG EGFR EREG BTC CBL LOSS OF FUNCTION OF TGFBR1 IN CANCER%REACTOME DATABASE ID RELEASE 76%3656534 Loss of Function of TGFBR1 in Cancer TGFB1 SMAD3 TGFBR1 TGFBR2 FKBP1A SMAD2 POST-TRANSLATIONAL PROTEIN MODIFICATION%REACTOME%R-HSA-597592.7 Post-translational protein modification CREBBP F8 SENP1 TRIM27 GGCX BGLAP PROZ GAS6 CFP HGS RAB5A RAB7A FUCA1 RAB3D SEMA5A RAB44 RAB37 RAB4B FCGR3B RAB24 RPS2 ARSA DAG1 ELOB ELOC COMMD9 ARSB BST1 H2AC19 COMMD3 CHD3 ACTB H2AC14 H2BC21 EP300 H2BU1 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 CDC25A KAT2A H2BC15 NUP107 DPH1 NUP188 DPH2 H2BC11 DPH3 DPH5 DNAJC24 DPH6 DPH7 HDAC2 HDAC1 MTA1 NUP210 NUP93 VCP POM121 RBBP7 NUP205 SEL1L H2BC9 AAAS H4C9 H2BC8 H2BC5 NUP160 POM121C H2BC3 NUP85 TPR H2BC1 NUP88 NUP155 NUP153 H2AC20 CP IFIH1 RNF135 PLAUR MAVS DDX58 RNF185 TRIM25 IKBKG NUP62 NDC1 NUP133 NUP50 NUP54 DERL1 DERL2 RNF5 DCAF7 UBE2B DTL OS9 TUBB6 NUP42 RAD18 TUBB3 NUP43 TUBB1 FBXO4 RAE1 RANBP2 MRTFA FBXO6 CDCA8 FBXW4 FBXW5 NUP35 FBXW10 NUP37 FBXW7 FBXW9 FBXW2 PRMT3 LRRC41 INCENP TDG FBXL3 FBXL5 TUBA1C TUBA1B TUBB2B TUBB2A USP11 TUBA3E MEN1 TUBA3D TUBA3C RANGAP1 CDC20 DAXX RWDD3 UBA2 SAE1 ALG2 B4GALT1 SDC2 GPC3 ST3GAL3 CTBP1 ST6GALNAC1 CMAS MPI GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ST6GAL2 ALG5 RENBP SKP2 DPM1 DPM2 DPM3 MVD ST6GALNAC5 GNE ST6GALNAC6 UAP1 NPL FUOM NEU2 NEU3 NEU4 GMDS AMDHD2 B4GALT2 NEU1 B4GALT3 ST8SIA4 B3GNT7 ST3GAL5 B3GNT4 ST8SIA5 B3GNT3 ST8SIA6 ST3GAL6 B3GNT2 CTSA B4GALT6 PMM1 ST8SIA1 VNN1 B4GALT4 ST8SIA2 VNN2 GFPT2 B4GALT5 GFPT1 PMM2 ST8SIA3 SRD5A3 DOLK NAGK NUS1 DHDDS FCSK GLB1 DOLPP1 EPAS1 HIF1A SOCS3 ICMT FOLR2 MGAT3 RRAGA SATB1 NOD1 NOD2 RIPK2 TRAF6 UBE2N TAB1 COL7A1 TFAP2B TFAP2C YY1 TPST2 TPST1 PEX2 CHST10 CHST8 LMAN1 DDX5 CD109 FBXL7 YKT6 UBA3 PEX10 UBE2M PEX12 PEX13 PEX14 FBXL18 PML HNRNPK MYC PGAP1 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 LYPD8 B3GALNT2 LYPD6B PIGS PIGU PIGT SMAD4 PIGO PIGN PIGP SMAD3 PIGZ SMURF2 PIGW PIGV PIGY PIGX LRRC49 PIGC NRIP1 PIGB PPARGC1A PIGA PIGK PIGM PIGL CHST4 PIGG TAF9B PIGF PIGH TTLL7 TTLL6 TAF10 TTLL5 TTLL4 TTLL3 TTLL2 USP4 TTLL1 USP2 ETFBKMT TTLL9 TTLL8 LY6K POFUT2 OTUD5 AGTPBP1 LY6D UBE2D2 LY6H UBE2D3 LY6E SPRN ETFB TNFAIP3 SPACA4 NICN1 MDGA2 MDGA1 RECK IKBKE NRN1 ART3 ART4 NTNG1 NTNG2 CYLD GPAA1 RAB22A B3GNTL1 TRAF3 CD52 KIN OTUD7B PRND UBE2K CAMKMT CNTN5 SERPINC1 ALPL PROS1 CNTN3 CNTN4 ALPG VCPKMT GALNT9 GALNT8 TEX101 RAB40A RAB40B RAB40C FGA GALNT7 SERPIND1 GALNT6 F10 GALNT5 GALNT4 TPGS1 TPGS2 ALG10B FGG GPLD1 GP2 GALNTL5 F5 BIRC2 GALNTL6 F7 ASGR1 BIRC3 ASGR2 PRSS21 PROC FN3KRP F9 GCNT1 METTL21A GCNT3 GCNT4 GCNT7 AGBL5 AGBL4 USP21 PRSS41 OTULIN AGBL1 AGBL3 A4GNT NCOA1 AGBL2 EEF1AKMT2 EEF1AKMT1 NCOA2 RAB3B RAB3C RAB42 LARGE2 TECTA TECTB RAB2B VASH2 VASH1 RAB34 TTLL13P TOP2B TOP1 EEF1A1 FN3K PLET1 CPM PSCA RTN4RL2 EEF2 METTL22 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 EEF2KMT RAB29 RAB15 RAB19 BLM RAB17 TTLL10 TTLL11 TTLL12 UMOD OTOA RAET1G VNN3 RAET1L IZUMO1R BARD1 B3GNT9 B3GNT8 CEACAM7 NRN1L B3GNT6 CEACAM5 B3GNT5 LY6G6C LY6G6D LSAMP GALNT11 GALNT14 GALNT13 GALNT16 BRCA1 GALNT15 GALNT18 ALPI ING2 GALNT17 GALNT10 ALG10 NTM ULBP2 POMGNT2 OPCML NEGR1 XPNPEP2 POMK APOB WRN RPA1 CALM1 FUT3 DYNLL2 HIF3A B4GALNT2 CUL2 VHL TUBB8 TUBB8B DNMT1 SUDS3 DNMT3B SUZ12 MDC1 DDB2 PCNA NPM1 IGFBP3 PTEN RABGGTB RABGGTA BIRC5 DCAF13 FN1 B3GLCT ADAMTS12 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS17 SYVN1 B4GAT1 US11 CETN2 CCP110 ACTR1A TUBA1A BTRC MUC5AC ADAMTS20 THSD7B C1GALT1C1 RAB8A GATA3 THSD7A ALG8 ALG9 SKP1 ALG6 HDAC7 ALG3 ALG1 FBXW11 MUC12 MUC15 CSNK1D MUC3A CBX5 DYNLL1 MUC3B MUC16 MUC17 UBXN1 MUC19 NGLY1 MUC20 RNF139 MUC21 MLEC UGGT2 UGGT1 MARCHF6 UBA52 EDEM3 MUC5B PDIA3 EDEM1 NLRP3 ADAMTSL1 AMFR DYNC1I2 RNF103 ADAMTSL5 TRIM13 DCTN2 ADAMTSL4 CALR ADAMTSL3 ENGASE DCTN3 ADAMTSL2 CUL1 AURKA HLA-B IL6 LARGE1 ADAMTS2 ADAMTS3 ADAMTS6 UBB ADAMTS7 THSD1 THSD4 UBC RPS27A C4A CAPZB SIN3A DYNC1H1 TUBB4B TUBB4A ALG14 ALG13 CDK1 ALG12 ALG11 PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR3C2 PIAS1 NR4A2 NR5A1 AR RXRA SUMO1 SUMO3 HLA-A SUMO2 POMGNT1 RARA RFT1 PPARG PGR PPARA CAPZA1 CAPZA2 THBS2 MUC1 MUC2 EIF5A MUC7 EIF5A2 MUC4 DHPS MUC6 DOHH USP13 RNF146 PCSK9 OTUD3 UBE2C UBE2E1 IGFBP1 UBE2D1 UBE2S FBXO32 SPON2 SPON1 PSMD8 CSF1 PSMD9 TNC APOA2 PSMD6 DMP1 APOA1 PSMD7 LGALS1 SBSPON PSMD4 CDH2 EVA1A APOA5 PSMD5 CCN1 DPAGT1 PSMD2 CHGB PSMD3 IGFBP5 PSMD1 SSPOP IGFBP4 PSMA5 APLP2 PSMA6 SHISA5 PDIA6 PSMA3 MXRA8 SPARCL1 PSMA4 PSMA1 SCG3 PSMA2 GALNT3 SCG2 PSME3 SAR1B LTBP1 PSME4 HSP90B1 PSME1 STC2 PSME2 IGFBP7 PSMD10 AMELX PSMB11 WFS1 PSMD12 AMBN FUCA2 PSMD11 APOE PSMD14 TMEM132A PSMD13 BMP4 HRC GPIHBP1 PSMA7 CALU MELTF PSMB10 PSMA8 FBN1 MBTPS1 PSMB6 OTUB2 SERPINA10 PSMB7 MSLN OTUD7A PSMB4 CHRDL1 VCPIP1 PSMB5 PRSS23 ZRANB1 PSMB2 BMP15 YOD1 PSMB3 QSOX1 APC PSMB1 RNF128 AHSG PSMF1 TNIP1 MEPE TNIP2 ALB DNAJC3 PSMB8 P4HB RCN1 TNIP3 PSMB9 VGF OTUB1 ENAM SEMA5B SEM1 PSMC5 AMTN PSMC6 VWA1 PSMC3 USP7 FAM20C PSMC4 CUL5 FAM20A DDB1 PSMC1 MFGE8 MPDU1 PSMC2 MATN3 ITIH2 AFP COPS7B FSTL1 COPS7A FSTL3 CUL4A CST3 SPP2 COPS3 MUCL1 APOL1 GOLM1 COPS6 LAMB2 COPS5 NUCB1 ERCC8 NOTUM C1GALT1 PNPLA2 GALNT12 COPS8 CDC73 CUL4B CTR9 SMAD2 WDR61 RTF1 LEO1 PAF1 UBE2Z UBE2L3 UBE2Q2 RNF152 RIPK1 POMT2 SHPRH TRAF2 UBE2E3 POMT1 RNF40 RNF144A CDC34 UBE2R2 APP SELENOS WAC ST6GALNAC2 UBA6 RPN2 BCL10 UBE2J2 PRKCSH HLTF TUSC3 RPN1 TMEM129 UBE2H MAGT1 UBE2G1 FUT8 GANAB UBE2A UBE2G2 UBE2W MAN2A1 MGAT5 UBE2T ST3GAL4 RNF181 MGAT1 UBA1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 LHB C3 SLC35A1 SLC35C1 PENK RING1 CGA MUC13 CKAP4 KTN1 TFG F2 DYNC1LI1 DYNC1LI2 CUL7 ARF3 ARF4 ARF1 SERPINA1 CHM AREG LRR1 CCNF COPZ2 DCAF8 DCAF5 VDAC3 DCAF4 COPZ1 VDAC2 DCAF6 VDAC1 FBXO7 FBXO9 WSB1 WSB2 FBXO2 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 ARF5 FBXL8 FBXL4 DDA1 ANKRD9 UBXN7 COMMD2 COMMD1 USO1 COMMD6 COMMD7 COMMD4 COMMD5 TRIM28 GAN KLHL2 LMAN2 KLHL3 STX5 SPSB3 KLHL9 SPSB2 CHML SPSB1 TRAPPC10 KBTBD6 ARCN1 KLHL5 CCDC8 KBTBD8 SPSB4 RAB3A ADRB2 FBXO27 FBXO21 RAB43 FBXO22 RAB41 FBXW12 KNG1 CISH FBXW8 RAB32 FBXO17 FBXO15 RAB30 L3MBTL2 LMO7 FBXO10 RAB31 FBXO11 ANO8 RAB36 KLHL41 RAB35 RAB38 KCTD7 KLHL42 GRIA1 CUL9 KLHL11 RAB5B KLHL13 RAB5C FBXO44 FBXO41 SOCS2 FBXO40 BTBD1 RAB6A UBD NAE1 SOCS6 RAB6B SOCS5 WDTC1 UBE2F KLHL25 TRAPPC2 ZBTB16 ANKRD28 KLHL21 TRAPPC3 KLHL22 SEC16B RAB4A BTBD6 FBXO30 FBXO31 TRAPPC1 BMI1 KLHL20 TRAPPC4 CCDC22 SEC16A KBTBD13 COMMD10 SATB2 TRAPPC5 TULP4 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 TRAPPC9 FBXL22 FBXL21P ASB15 CNIH1 ASB16 FBXL20 DCAF16 DCAF17 ASB10 CNIH2 FEM1C CNIH3 MCFD2 DCAF10 ARRB1 DCAF11 ARRB2 FEM1A FEM1B FBXL19 FBXL15 FBXL16 PPP6C FBXL13 FBXL14 FBXL12 PPP6R1 NEURL2 PPP6R3 ASB8 ASB9 RNF2 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 ARFGAP3 SPTB ARFGAP1 BET1L ARFGAP2 SEC22B SEC22A SEC22C RAB1A SEC23A RAB1B RAB21 PHC2 PHC1 SEC24B SEC24A RAB10 CAND1 PHC3 RAB14 RAB12 RAB13 RAB18 SEC24D SEC24C FOLR1 BET1 KDELR1 GOLGA2 RUVBL1 NFRKB ZNF350 PARP1 COG8 COG7 ACTR5 COG6 LMAN1L ACTL6A COG5 COG4 RAD23A COG3 ACTR8 ADAM10 COG2 RAD23B COG1 ANK2 UBE2V2 INO80C ANK3 INO80B ANK1 INO80E INO80D PCGF2 XPC PREB TFPT KDELR2 KDELR3 MCRS1 ADAMTS16 INO80 CFTR SPTBN4 SPTBN5 ADAMTS18 LMAN2L TGFA TGOLN2 SCFD1 SEC31A SPTBN2 LAMC1 RAB39A ADAMTS4 RAB27A ADAMTS5 RAB39B RAB27B ADAMTS1 STAM TF TIMP1 ADAMTS8 RAB2A ADAMTS9 CTSZ MIA2 MIA3 TMED3 TMED2 TMED7 CTSC RAB8B SEC13 TMED9 RAB33A RAB33B RAB7B NAPA NAPB FURIN STX17 NEDD8 SPP1 NAPG CD59 LAMB1 DYNC1I1 CD55 GBF1 RAB11A WDR5 RAB11B SEC23IP PRKDC CAPZA3 RAB9A COPG2 COPG1 ACTR10 RAB9B RBBP5 NSF TRAPPC2L TBC1D20 FGF23 STAM2 COPB2 COPA TMED10 COPB1 SPTA1 MAN2A2 KCTD6 TRRAP KEAP1 CBX8 H2AC17 H2AC12 USP17L4 CBX4 USP17L5 CBX2 USP17L8 USP17L30 HCFC1 RNF123 BRCC3 SNX3 RHOT1 RCE1 TMEM115 SIAH2 TADA2B H2AC21 BAP1 H2AW COPE WDR48 IDE BABAM1 BABAM2 THBS1 UCHL1 UIMC1 MAN1A2 UFD1 MAN1A1 TOMM70 JOSD2 UCHL3 JOSD1 BPIFB2 UCHL5 PTRH2 PRKN WDR20 USP17L21 TRAPPC6A USP17L20 USP17L22 HSPA8 STAMBPL1 USP17L15 MBD5 USP17L18 TRAPPC6B MBD6 GORASP1 USP17L17 USP17L19 USP17L10 USP17L2 USP17L12 USP17L3 USP17L11 USP17L1 USP17L13 DCTN6 KDM1B DCTN5 TOMM20 ATXN3L DCTN1 USP8 GOSR2 USP5 DCTN4 USP3 MUL1 GOSR1 SPTAN1 H2AC1 FKBP8 INS STAMBP SPTBN1 FOXO4 ATXN3 ATXN7 SMC5 CLSPN USP9X PARK7 SMAD1 SMC6 SMAD7 SMC3 TADA3 OGT HERC2 MAN1C1 DDX17 USP37 NSMCE3 USP33 NSMCE2 USP34 NSMCE1 MYSM1 GALNT2 MITF POLB HIC1 SENP8 EID3 GALNT1 USP30 RAD21 USP47 ZBED1 USP48 TP53BP1 USP49 XRCC4 USP42 STAG1 USP44 STAG2 AXIN1 SP3 AXIN2 H2BC18 ZNF131 BECN1 SENP5 FOXL2 USP14 SMC1A USP15 SENP2 USP16 SAFB USP10 RNF168 ABRAXAS1 NSMCE4A USP12 FOXK2 SP100 UHRF2 FOXK1 CASP8AP2 NUP214 ABRAXAS2 NOP58 MAT2B MBD1 USP18 RAD52 USP19 USP24 USP25 USP26 USP20 USP22 ADRM1 AURKB USP28 ASXL1 HIPK2 ASXL2 NCOR2 MANEA CCNA2 CCNA1 TP53 COP1 CDKN2A MDM2 MDM4 RBX1 TOP2A STS VCAN SUMF2 SUMF1 IL33 RNF20 CUL3 GPS1 COPS4 COPS2 ARSL ARSJ HNRNPC ARSK ARSH ARSI ARSF ARSG ARSD NFKBIA RELA TOPORS NFKB2 KBTBD7 TNKS2 TNKS TGFB1 SLC17A5 TGFBR1 RHOA TGFBR2 MAP3K7 CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 76%2559583 Cellular Senescence CBX8 CBX6 CBX4 CBX2 MAP2K6 BMI1 CXCL8 MAPK1 RPS6KA3 IL1A RPS6KA2 RPS6KA1 MAPK3 ACD TINF2 RNF2 TERF1 TERF2 CEBPB H3-4 POT1 TERF2IP RAD50 NFKB1 MAPK8 PHC2 PHC1 RING1 UBA52 EZH2 PHC3 STAT3 EED IL6 UBB RB1 MAPK7 ASF1A SUZ12 TFDP1 MAPKAPK2 UBC JUN CDK6 LMNB1 TFDP2 RPS27A CDK4 E2F1 UBN1 E2F2 E2F3 CDKN2D CDKN2C TNRC6C MOV10 MAP3K5 ERF TNIK TNRC6A TNRC6B MAPK14 MAPK11 CDKN2B CDKN1A TXN CDKN1B CCNA2 CCNA1 CCNE2 CCNE1 TP53 CDKN2A CDK2 MDM2 ID1 ATM MDM4 MINK1 HIRA MAP4K4 ETS1 IFNB1 ETS2 FOS SP1 EP400 AGO3 AGO4 AGO1 HMGA1 HMGA2 H2AX EHMT2 CABIN1 H2AB1 H2AC19 KDM6B H2AC14 FZR1 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ANAPC15 ANAPC16 ANAPC7 H2BC17 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 ANAPC10 H2BC14 ANAPC11 H2AJ CDC23 UBE2S H2BC15 CDC26 CDC16 CDC27 ANAPC4 H2BC11 ANAPC5 ANAPC1 H3C15 RBBP4 H2BS1 RBBP7 H2AZ1 H2BC9 IGFBP7 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 MAP2K3 MAP2K4 MAPKAPK3 MAP2K7 H1-1 H1-0 H1-3 H1-2 RELA H1-5 H1-4 MAPK9 MAPK10 MRE11 EHMT1 VENTX KAT5 NBN MAPKAPK5 PLUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 76%164525 Plus-strand DNA synthesis gag rev gag-pol vif PPIA vpr vpu MASITINIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669924.1 Masitinib-resistant KIT mutants KIT ROLE OF PHOSPHOLIPIDS IN PHAGOCYTOSIS%REACTOME%R-HSA-2029485.1 Role of phospholipids in phagocytosis V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 SYK V5-6 IGLV3-19 ITPR1 ITPR2 ITPR3 PLD1 IGLV3-25 PLPP5 IGLV3-27 PLPP4 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 PIK3R1 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 PIK3R2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 PLD4 IGKV1D-12 PLD3 IGLV1-51 IGLV2-23 PRKCD IGKV3-20 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 FCGR2A PIK3CA PLCG1 PLA2G6 CD3G AHCYL1 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 PIK3CB IGHV3-9 PRKCE IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 PLD2 V1-16 V1-13 IGHV1-69 PLCG2 INACTIVATION OF CDC42 AND RAC1%REACTOME DATABASE ID RELEASE 76%428543 Inactivation of CDC42 and RAC1 SRGAP3 RAC1 SRGAP1 ROBO1 CDC42 ARHGAP39 SRGAP2 SLIT2 GROWTH HORMONE RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 76%982772 Growth hormone receptor signaling STAT5A STAT5B STAT1 IRS1 CSH1 PRL IRS2 PRLR GHR GH1 CISH SOCS3 PTPN1 JAK2 STAT3 ADAM17 MAPK1 SOCS1 PTPN6 SOCS2 MAPK3 LYN NTF4 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME%R-HSA-9026357.1 NTF4 activates NTRK2 (TRKB) signaling NTF4 NTRK2 SURFACTANT METABOLISM%REACTOME%R-HSA-5683826.3 Surfactant metabolism SLC34A2 P2RY2 SFTPB SFTPD ADA2 CTSH ABCA3 SFTA3 SFTPA2 SFTPC CSF2RB TTF1 CSF2RA CKAP4 ZDHHC2 DMBT1 LMCD1 SLC34A1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADRA2C ADGRF5 SFTPA1 ADRA2A GATA6 ADORA2A ADORA2B EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME%R-HSA-9630750.3 Evasion of Oncogene Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A CDK4 PHASE 0 - RAPID DEPOLARISATION%REACTOME%R-HSA-5576892.2 Phase 0 - rapid depolarisation SCN10A SCN1B SCN1A CACNG6 CACNG7 SCN5A SCN4A SCN4B SCN3B CACNB1 SCN3A CACNA2D2 CACNB2 RANGRF SCN7A SCN2A SCN2B CAMK2B CAMK2D CAMK2A CACNG8 CAMK2G CACNG4 SCN9A SCN11A SCN8A CALM1 CACNA1C FGF14 FGF13 FGF12 FGF11 SIGNALING BY NTRKS%REACTOME DATABASE ID RELEASE 76%166520 Signaling by NTRKs NGF PPP2R1B BRAF FRS3 PPP2R5D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 NTRK3 DNM1 NTF3 DNM2 PPP2CA CRKL PPP2CB DNM3 RRAD ASCL1 LYL1 JUND EGR3 EGR4 FOSL1 ARC SGK1 ID2 ID4 PTPN11 FOSB ID3 KIDINS220 PPP2R1A TRIB1 CLTC PTPRO CDK5R2 PIK3R1 TIAM1 JUNB RAPGEF1 ADORA2A RALA PIK3R2 CDK5R1 NTRK1 NTRK2 ADCYAP1 ADCYAP1R1 CDK5 MAP2K1 MAP2K2 YWHAB STAT3 SHC3 DOCK3 DUSP4 TPH1 DUSP3 VRK3 DUSP6 SRF TCF12 DUSP7 MAPK7 MAPKAPK2 CREB1 RAC1 MAPK14 MAPK11 ATF2 SRC PTPRS NELFB SHC1 GAB1 ID1 PIK3CA PLCG1 SOS1 FOS MEF2D NTF4 BDNF GRIN2B CHD4 EP300 CLTA AP2A1 PCSK6 AP2A2 SHC2 RALGDS PCSK5 DNAL4 RALB RIT1 FURIN RIT2 AP2M1 REST NAB1 NAB2 MAP2K5 CRK EGR2 F3 AP2S1 BAX SH3GL3 ATF1 EGR1 MAPK12 AP2B1 MAPK13 IRS1 MAPKAPK3 SH3GL2 HRAS IRS2 PIK3CB VGF NRAS RAP1A FRS2 RHOA G ALPHA (Q) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 76%416476 G alpha (q) signalling events PLCB3 PLCB1 PLCB2 NMUR2 NMUR1 GAST MLNR PLCB4 HTR2B TRIO RGSL1 HTR2C OXT ADRA1D RGS4 RGS5 HTR2A MAPK1 RPS6KA3 RGS2 RGS3 TRH RPS6KA2 RGS1 RPS6KA1 ADRA1B MAPK3 ADRA1A GRK5 LTB4R BDKRB2 BDKRB1 QRFPR RGS18 RGS17 RGS19 GNRHR2 RGS13 RGS16 RGS21 GCG XCL2 XCL1 PIK3R2 P2RY6 P2RY2 P2RY1 CCK HCRTR2 HCRTR1 KISS1 MMP3 PRKCE RASGRP2 RASGRP1 GRK2 TRPC7 TRPC6 TRPC3 NPFFR2 APP OXTR NPFFR1 GRPR ITPR1 GNG10 ITPR2 ITPR3 EDNRA EDNRB GNG12 KALRN GNG11 GNG13 PROK2 PROK1 GNB2 GNAQ GNB1 UTS2R GNB4 GNB3 NPFF GNB5 TRHR PIK3R1 GNGT1 UTS2B AGTR1 GNGT2 PTGFR LPAR1 LPAR2 LPAR3 LPAR4 FPR2 GNA14 GNG3 GNA15 HCRT GNG2 GNG5 NTSR1 GNG4 NTSR2 GNG7 GNA11 GPR17 GNG8 NMB XCR1 NMBR LPAR5 LPAR6 NMS NMU GNRH2 GNRH1 PRKCD QRFP PRKCA MAPK7 MLN BRS3 GPR132 CCKAR FFAR4 GNRHR DGKG FFAR3 DGKE DAGLA FFAR2 DGKD CREB1 FFAR1 DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ DGKQ PRKCQ GPR39 EDN1 DAGLB EDN2 DGKK ANXA1 DGKI DGKH EDN3 AVPR1B TACR2 MGLL TACR3 AVPR1A TACR1 F2 PIK3CA CCKBR SOS1 AVP NPSR1 BTK GRP PTGER1 PTAFR ARHGEF25 NPS PROKR1 PROKR2 KISS1R P2RY10 P2RY11 GPR4 AGT GPR143 MT-RNR2 SAA1 F2RL1 F2RL2 F2RL3 GRM1 GPRC6A CHRM3 CHRM1 GPR68 GRM5 GPR65 CHRM5 PMCH HBEGF CYSLTR1 CYSLTR2 EGFR GHSR CASR F2R LTB4R2 UTS2 HRAS NTS MCHR1 MCHR2 KNG1 NRAS HRH1 TBXA2R PIK3R3 TAC3 TAC1 OPN4 DEFECTIVE CUBN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%R-HSA-3359463.1 Defective CUBN causes hereditary megaloblastic anemia 1 CBLIF CUBN AMN ASSEMBLY OF THE SARS-COV-1 REPLICATION-TRANSCRIPTION COMPLEX (RTC)%REACTOME DATABASE ID RELEASE 76%9683439 Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC) 1a rep TLR3-MEDIATED TICAM1-DEPENDENT PROGRAMMED CELL DEATH%REACTOME DATABASE ID RELEASE 76%9013957 TLR3-mediated TICAM1-dependent programmed cell death FADD RIPK3 TICAM1 CASP8 TLR3 RIPK1 MICROTUBULE-DEPENDENT TRAFFICKING OF CONNEXONS FROM GOLGI TO THE PLASMA MEMBRANE%REACTOME%R-HSA-190840.1 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane GJA1 LOSS OF FUNCTION OF FBXW7 IN CANCER AND NOTCH1 SIGNALING%REACTOME%R-HSA-2644607.1 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling RBX1 SKP1 NOTCH1 CUL1 TANDEM PORE DOMAIN POTASSIUM CHANNELS%REACTOME%R-HSA-1296346.2 Tandem pore domain potassium channels KCNK13 KCNK16 KCNK17 KCNK1 KCNK2 KCNK3 KCNK4 KCNK6 KCNK18 KCNK7 KCNK10 KCNK9 DEFECTIVE TBXAS1 CAUSES GHDD%REACTOME DATABASE ID RELEASE 76%5579032 Defective TBXAS1 causes GHDD TBXAS1 SIGNALING BY FLT3 FUSION PROTEINS%REACTOME DATABASE ID RELEASE 76%9703465 Signaling by FLT3 fusion proteins PIM1 STAT5A STAT5B HRAS NOX4 ZMYM2 PIK3CA SOS1 NRAS MYO18A PIK3R1 TRIP11 ETV6 GAB2 CDKN1A SPTBN1 DEFECTIVE SLC12A1 CAUSES BARTTER SYNDROME 1 (BS1)%REACTOME DATABASE ID RELEASE 76%5619104 Defective SLC12A1 causes Bartter syndrome 1 (BS1) SLC12A1 ION HOMEOSTASIS%REACTOME%R-HSA-5578775.2 Ion homeostasis ATP2A1 SLC8A1 SLC8A2 NOS1 FKBP1B KCNJ11 TRPC1 ASPH ATP1B3 TNNI3 STIM1 ATP1B2 ATP1B1 ORAI2 ORAI1 ITPR1 ITPR2 PLN ITPR3 SRI ATP2B4 ATP2B3 ATP2B2 FXYD4 ATP2B1 FXYD3 FXYD2 SLC8A3 FXYD1 FXYD7 FXYD6 PRKACA CALM1 TRDN ATP1A4 ATP1A3 ATP1A2 ATP1A1 SLN AHCYL1 CAMK2B RYR1 CAMK2D RYR2 CAMK2A CAMK2G RYR3 CLIC2 ABCC9 DMPK ATP2A3 ATP2A2 DEPYRIMIDINATION%REACTOME%R-HSA-73928.1 Depyrimidination H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 NTHL1 TDG MBD4 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 SMUG1 H2BC12 NEIL3 H2BC13 NEIL2 H3-4 H2BC14 POT1 H2AJ TERF2IP NEIL1 H2BC15 H2BC11 INTERACTION BETWEEN L1 AND ANKYRINS%REACTOME%R-HSA-445095.1 Interaction between L1 and Ankyrins SCN10A NFASC SPTBN4 SPTBN5 SCN1B SCN1A L1CAM KCNQ2 KCNQ3 SPTBN2 SCN5A SCN4A SCN4B SCN3B SCN3A SCN7A SCN2A SCN2B SCN9A NRCAM SPTB ANK2 SPTA1 ANK3 SCN11A ANK1 SCN8A SPTAN1 SPTBN1 DOWNREGULATION OF SMAD2 3:SMAD4 TRANSCRIPTIONAL ACTIVITY%REACTOME DATABASE ID RELEASE 76%2173795 Downregulation of SMAD2 3:SMAD4 transcriptional activity UBB HDAC1 USP9X PPM1A SMAD4 UBC SMAD3 UBE2D3 SKI RPS27A TGIF1 SMURF2 RNF111 PARP1 TGIF2 NCOR2 NCOR1 UBE2D1 UBA52 SKIL TRIM33 NEDD4L SMAD2 PROPIONYL-COA CATABOLISM%REACTOME%R-HSA-71032.2 Propionyl-CoA catabolism PCCB MCEE MMAA PCCA MMUT TNFR1-MEDIATED CERAMIDE PRODUCTION%REACTOME%R-HSA-5626978.1 TNFR1-mediated ceramide production RACK1 TNFRSF1A NSMAF TNF SMPD3 SMPD2 DEFECTIVE EXT1 CAUSES EXOSTOSES 1, TRPS2 AND CHDS%REACTOME%R-HSA-3656253.3 Defective EXT1 causes exostoses 1, TRPS2 and CHDS GPC5 GPC4 GPC6 EXT1 EXT2 SDC1 AGRN HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 PHOSPHORYLATION OF EMI1%REACTOME%R-HSA-176417.2 Phosphorylation of Emi1 PLK1 CDC20 FZR1 CDK1 CCNB1 FBXO5 DEFECTIVE OPLAH CAUSES OPLAHD%REACTOME DATABASE ID RELEASE 76%5578998 Defective OPLAH causes OPLAHD OPLAH EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME DATABASE ID RELEASE 76%9630794 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A CDK4 HIGHLY SODIUM PERMEABLE POSTSYNAPTIC ACETYLCHOLINE NICOTINIC RECEPTORS%REACTOME DATABASE ID RELEASE 76%629587 Highly sodium permeable postsynaptic acetylcholine nicotinic receptors CHRNG CHRNE CHRNB4 CHRNB2 CHRNA3 CHRND CHRNA4 GPVI-MEDIATED ACTIVATION CASCADE%REACTOME%R-HSA-114604.5 GPVI-mediated activation cascade PIK3CA LCK SYK FYN VAV3 RHOB RHOG VAV1 LYN FCER1G PIK3CB LCP2 PDPK1 PIK3R6 PIK3CG PIK3R5 PTPN11 RAC2 RAC1 PIK3R1 PDPN VAV2 MPIG6B PIK3R3 GP6 LAT CDC42 PRKCZ CLEC1B PTPN6 RHOA PIK3R2 PLCG2 SIGNALING BY MEMBRANE-TETHERED FUSIONS OF PDGFRA OR PDGFRB%REACTOME DATABASE ID RELEASE 76%9673768 Signaling by membrane-tethered fusions of PDGFRA or PDGFRB GOLGA4 ETV6 KDR KANK1 BIN2 RELAXIN RECEPTORS%REACTOME%R-HSA-444821.1 Relaxin receptors INSL3 RXFP4 INSL5 RLN2 RLN3 RXFP1 RXFP2 RXFP3 BIOSYNTHESIS OF DHA-DERIVED SPMS%REACTOME DATABASE ID RELEASE 76%9018677 Biosynthesis of DHA-derived SPMs ALOX5 EPHX2 PTGS2 HPGD LTA4H GSTM4 CYP2C9 ALOX15 CYP2C8 ALOX12 CYP2D6 CYP1A2 CYP2E1 CYP3A4 LTC4S CYP1A1 PROCESSIVE SYNTHESIS ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174414.3 Processive synthesis on the C-strand of the telomere POLD2 BLM LIG1 ACD TINF2 WRN TERF1 TERF2 PCNA RPA1 RPA2 POT1 TERF2IP RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 VLDLR INTERNALISATION AND DEGRADATION%REACTOME%R-HSA-8866427.3 VLDLR internalisation and degradation CLTC AP2A1 NR1H2 AP2B1 VLDLR AP2A2 AP2S1 AP2M1 MYLIP PCSK9 CLTA NR1H3 ACTIVATION OF BH3-ONLY PROTEINS%REACTOME%R-HSA-114452.2 Activation of BH3-only proteins BCL2L11 TP53 PPP3R1 BCL2 BBC3 TP53BP2 DYNLL1 TP73 BID YWHAB PPP1R13B YWHAQ AKT2 SFN YWHAH AKT1 BAD YWHAZ TFDP1 TFDP2 YWHAE E2F1 PPP3CC PMAIP1 YWHAG MAPK8 TP63 BMF DYNLL2 AKT3 FGFR3B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190371 FGFR3b ligand binding and activation FGF1 FGF18 FGF9 FGF20 LEISHMANIA PHAGOCYTOSIS%REACTOME%R-HSA-9664417.1 Leishmania phagocytosis V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV LPG1G2 CYFIP1 V5-4 NCKAP1 V5-1 ARPC4 SYK FGR ARPC5 FYN VAV3 V5-6 HCK MAPK1 BRK1 VAV1 IGLV3-19 ARPC2 ELMO2 ARPC3 MAPK3 WAS IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 MYH9 IGKV1-5 ACTR2 MYO9B WASL VAV2 IGLV IGHG3 CDC42 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 NCK1 ABL1 IGHV4-59 NCKAP1L WASF1 IGLV2-11 NCKIPSD WASF2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MYO1C IGKV3-15 BAIAP2 IGKV3-11 V2-8 ABI2 IGLV7-43 ARPC1B ABI1 ACTG1 IGKV1D-16 IGKV1D-12 LYN YES1 IGLV1-51 IGLV2-23 IGKV3-20 PTK2 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 MYO5A BTK ACTB CD3G ARPC1A ELMO1 CRK CYFIP2 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 DEFECTIVE POMT1 CAUSES MDDGA1, MDDGB1 AND MDDGC1%REACTOME DATABASE ID RELEASE 76%5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 POMT1 DAG1 POMT2 AUTOINTEGRATION RESULTS IN VIRAL DNA CIRCLES%REACTOME%R-HSA-177539.2 Autointegration results in viral DNA circles gag BANF1 rev gag-pol vif HMGA1 vpr PSIP1 vpu TRUNCATIONS OF AMER1 DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME DATABASE ID RELEASE 76%5467348 Truncations of AMER1 destabilize the destruction complex PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 U12 DEPENDENT SPLICING%REACTOME%R-HSA-72165.1 U12 Dependent Splicing PDCD7 EFTUD2 TXNL4A SNRNP35 PRPF6 SNRPG SNRPE SNRPF SNRNP25 POLR2A POLR2B SNRNP200 POLR2C POLR2D SNRPB POLR2E PRPF8 POLR2F ZMAT5 POLR2G POLR2H POLR2I POLR2J SRSF2 POLR2K POLR2L SRSF6 LSM2 SRSF7 GTF2F1 GTF2F2 DDX42 YBX1 SRSF1 DDX23 ZCRB1 SNRNP40 SF3B1 SNRNP48 SNRPD2 SNRPD1 SNRPD3 NCBP1 SNU13 RNPC3 NCBP2 ZRSR2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 PI5P, PP2A AND IER3 REGULATE PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 76%6811558 PI5P, PP2A and IER3 Regulate PI3K AKT Signaling PPP2R1B PPP2R5E ESR1 GAB1 TGFA STRN PIK3CA FLT3 PPP2R5B PPP2R5A LCK PPP2R5D PPP2R5C CD28 KIT FYN MAPK1 RHOG VAV1 PIP5K1C MAPK3 PDGFB PPP2CA PPP2CB PDGFRB HGF ERBB2 ESR2 PTPN11 CD86 CD80 PPP2R1A PIK3R1 AREG PIK3R2 INS IRAK4 TRAT1 NRG1 MYD88 NRG2 PIK3AP1 NRG3 NRG4 IL1RL1 IL33 EGF EPGN HBEGF EGFR IER3 PIP5K1A PIP5K1B AKT1 KLB IRS1 PDGFRA IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PIK3CD FGF20 RAC2 RAC1 FGF23 FGF22 INSR FLT3LG PIK3R3 FRS2 PIP4K2A GAB2 PIP4K2B MET IRAK1 FGF16 FGF19 EREG FGF18 PIP4K2C BTC TRAF6 FGFR4 SRC FGF10 CD19 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME%R-HSA-9632697.2 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 TOLL LIKE RECEPTOR 10 (TLR10) CASCADE%REACTOME DATABASE ID RELEASE 76%168142 Toll Like Receptor 10 (TLR10) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 NFKBIB fliC TLR10 FBXW11 IRAK4 TLR5 SAA1 MYD88 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 SYNTHESIS, SECRETION, AND INACTIVATION OF GLUCAGON-LIKE PEPTIDE-1 (GLP-1)%REACTOME DATABASE ID RELEASE 76%381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) GNG13 TCF7L2 GNAT3 FFAR4 GNB3 CTNNB1 PCSK1 CDX2 GPR119 DPP4 GCG SPCS3 FFAR1 SPCS2 SPCS1 LEP SEC11A SEC11C GRP PAX6 CLEC7A (DECTIN-1) INDUCES NFAT ACTIVATION%REACTOME%R-HSA-5607763.1 CLEC7A (Dectin-1) induces NFAT activation NFATC2 PPP3R1 CALM1 AHCYL1 ITPR1 PPP3CA NFATC3 ITPR2 PPP3CB NFATC1 ITPR3 SIGNALING BY NOTCH%REACTOME DATABASE ID RELEASE 76%157118 Signaling by NOTCH CREBBP JAG2 RUNX1 HEY1 HEY2 MDK ACTA2 FCER2 NEURL1B MIB2 MIB1 HEYL ARRB1 ARRB2 STAT1 CDK8 HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC6 NEURL1 JAG1 PLXND1 UBA52 CUL1 UBB TFDP1 UBC TFDP2 RPS27A CCND1 E2F1 E2F3 MAML2 MAML1 RBPJ MYC ADAM10 ADAM17 MAML3 SIRT6 ELF3 MFNG NOTCH1 HDAC4 RFNG PSEN1 HES1 NCSTN SMAD3 SNW1 MAMLD1 TLE4 TLE2 TLE1 PRKCI H2AX H2AB1 H2AC19 H2AC14 NBEA H2BC21 EP300 H2BU1 H3-3B WWP2 H3C8 TMED2 H2AC8 PSEN2 YBX1 APH1A H2AC6 H2AC7 APH1B H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ PBX1 KAT2A H2BC15 FURIN H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 HDAC2 PSMD4 PSENEN HDAC1 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 H2BS1 PSMA4 PSMA1 CNTN1 PSMA2 PSME3 SEL1L H2AZ1 PSME1 H2BC9 PSME2 PSMD10 H2AZ2 H4C9 H2BC8 PSMD12 H2BC5 PSMD11 PSMD14 H2BC3 PSMD13 PSMA7 H2BC1 PSMB10 PSMB6 PSMB7 H2AC20 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 TBL1XR1 PSMC4 PSMC1 TBL1X PSMC2 ATP2A3 ATP2A2 ATP2A1 HDAC3 ST3GAL4 DNER DLGAP5 WWC1 DTX1 DTX2 PTCRA DLK1 POGLUT1 POFUT1 EGF NOTCH2 LFNG NOTCH3 NOTCH4 DTX4 AKT1 FLT4 YWHAZ JUN NCOR2 TNRC6C MOV10 CREB1 NCOR1 TNRC6A TNRC6B B4GALT1 FABP7 TP53 ST3GAL3 RBX1 AGO3 AGO4 AGO1 AGO2 GZMB NUMB ST3GAL6 ITCH TACC3 HIF1A EGFR HDAC10 HDAC11 CCNC RAB6A DEFECTIVE SLC9A6 CAUSES X-LINKED, SYNDROMIC MENTAL RETARDATION,, CHRISTIANSON TYPE (MRXSCH)%REACTOME%R-HSA-5619092.1 Defective SLC9A6 causes X-linked, syndromic mental retardation,, Christianson type (MRXSCH) SLC9A6 SYNTHESIS OF PIPS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 76%8847453 Synthesis of PIPs in the nucleus PIP4K2A PIP4K2B PIP4K2C PIP4P1 OPSINS%REACTOME%R-HSA-419771.1 Opsins OPN5 OPN1SW OPN1LW RRH OPN1MW RHO OPN4 OPN3 RGR VIF-MEDIATED DEGRADATION OF APOBEC3G%REACTOME%R-HSA-180585.1 Vif-mediated degradation of APOBEC3G ELOB ELOC vif RBX1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 CUL5 PSMC4 PSMC1 PSMC2 DOWNREGULATION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 76%8863795 Downregulation of ERBB2 signaling NRG1 NRG2 NRG3 NRG4 EGF UBA52 HBEGF EGFR AKT2 AKT1 RNF41 UBB HSP90AA1 CDC37 UBC ERBB2 ERBIN RPS27A PTPN12 CUL5 STUB1 USP8 EREG BTC PTPN18 MATK AKT3 NEGATIVE REGULATION OF NMDA RECEPTOR-MEDIATED NEURONAL TRANSMISSION%REACTOME DATABASE ID RELEASE 76%9617324 Negative regulation of NMDA receptor-mediated neuronal transmission GRIN2C CAMK2B CAMK2D CAMK2A CAMK2G CAMK4 CAMK1 ACTN2 GRIN2B GRIN1 GRIN2D DLG1 DLG2 CALM1 DLG3 PPM1E LRRC7 DLG4 PPM1F NEFL GRIN2A TETRAHYDROBIOPTERIN (BH4) SYNTHESIS, RECYCLING, SALVAGE AND REGULATION%REACTOME%R-HSA-1474151.5 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation GCH1 PTS HSP90AA1 PRKG2 DHFR NOS3 SPR CALM1 AKT1 GCHFR INTERLEUKIN-2 SIGNALING%REACTOME%R-HSA-9020558.2 Interleukin-2 signaling IL2RA STAT5A SYK IL2 STAT5B IL2RG JAK3 SHC1 IL2RB PTK2B JAK1 LCK RRNA MODIFICATION IN THE MITOCHONDRION%REACTOME DATABASE ID RELEASE 76%6793080 rRNA modification in the mitochondrion NSUN4 MTERF4 TFB1M MRM1 MRM2 MRM3 CYTOCHROME C-MEDIATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 76%111461 Cytochrome c-mediated apoptotic response AVEN APAF1 CASP9 CASP7 DIABLO UACA CARD8 XIAP MAPK1 CASP3 MAPK3 APIP CYCS SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR3%REACTOME%R-HSA-1839130.1 Signaling by activated point mutants of FGFR3 FGF23 FGF16 FGF1 FGF18 FGF2 FGF4 FGFR3 FGF9 FGF20 SYNTHESIS OF DOLICHYL-PHOSPHATE%REACTOME%R-HSA-446199.1 Synthesis of Dolichyl-phosphate MVD SRD5A3 DOLK NUS1 DHDDS DOLPP1 LOSS OF PROTEINS REQUIRED FOR INTERPHASE MICROTUBULE ORGANIZATION FROM THE CENTROSOME%REACTOME DATABASE ID RELEASE 76%380284 Loss of proteins required for interphase microtubule organization from the centrosome HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 DEFECTIVE HEXB CAUSES GM2G2%REACTOME DATABASE ID RELEASE 76%3656248 Defective HEXB causes GM2G2 HEXB INNATE IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 76%168249 Innate Immune System CREBBP PPP3R1 RHOF DIAPH1 NFATC1 SDCBP FYN PAK3 ATP6V1H MAPK1 CDA FRMPD3 GMFG MAPK3 ABCA13 NHLRC3 MCEMP1 ARMC8 SCAMP1 CD180 NOS2 RNASE2 LY86 UNC13D LBP FLG2 PADI2 A1BG CFP PLAC8 KPNB1 CRACR2A PRDX4 GSN S100A11 RAB7A FUCA1 PA2G4 AZU1 HRNR TCN1 TOLLIP SERPINA3 PYGB PIGR SIGLEC9 LPCAT1 PYGL OLR1 SERPINB3 SERPINB1 NFAM1 PGAM1 TMC6 SERPINB6 PLEKHO2 SERPINB10 SERPINB12 GRN ASAH1 METTL7A AGA AGL ERP44 LRG1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX RAB44 LAMP1 CLEC5A LAMP2 TOM1 MAP2K1 KCMF1 IST1 OLFM4 ILF2 ACLY CLEC4C CLEC4D RAB37 DSC1 PLD4 ARL8A PLD3 BRI3 UBR4 RAB4B PTPRB NIT2 PTPRC SNAP25 ITGAM ITGB2 FCAR ALAD FCGR3B GM2A ITGAX ACP3 PGM1 RNASET2 NDUFC2 TREM2 PKM ITGAV DNAJC5 TMBIM1 CANT1 FGL2 RAB24 CPPED1 PFKL CHIT1 MGAM VAPA MNDA FOLR3 VPS35L CALML5 ANPEP CPNE1 CPNE3 GOLGA7 ARSA C6orf120 NFASC KRT1 MIF SLPI CRISPLD2 TMEM63A MMTAG2 SYNGR1 COMMD9 ARSB VAT1 PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 BST1 CYSTM1 ORM1 PTPRJ ORM2 GLIPR1 ACTR1B CTSH CD33 LRRC7 CD53 MANBA FCER1G MME GAA NME2 COMMD3 CAP1 CEACAM3 ACTB RAP2C TTR CEACAM1 RAP2B LCP2 EP300 CEACAM6 ALDOC CEACAM8 CD47 ALDOA DNASE1L1 CSTB CD63 LILRA3 PGRMC1 CREG1 ORMDL3 CD58 LAIR1 GCA TYROBP PTGES2 APEH HUWE1 LILRB2 LILRB3 POLR1C SVIP QPCT CD68 POLR1D SRP14 PLAU COTL1 SIRPA ENPP4 OSTF1 CHRNB4 CD93 CD300A IRAG2 ATAD3B OSCAR DOK3 PPIA VCP ADGRG3 CNN2 DPP7 ALDH3B1 GGH ADA2 DNAJC13 SELL TARM1 MAN2B1 DEGS1 MS4A3 DDX3X TNFAIP6 CRISP3 SIRPB1 HEBP2 HK3 ADGRE5 NAPRT ADGRE3 MAPK12 HGSNAT DYNLT1 MAPK13 IFIH1 IKBKB ATP6AP2 RNF135 PLAUR CHI3L1 MAVS CHUK PDXK DDX58 CLEC12A CASP10 MVP TRIM25 AGPAT2 IKBKG CASP9 TMEM30A CMTM6 PDAP1 GALNS PTX3 S100P GLA CD209 JUP VAV3 ARHGAP9 CSNK2B RHOG VAV1 ELMO2 PLD1 IQGAP2 RIPK3 DHX9 NFKB1 NKIRAS1 NKIRAS2 TLR3 NFKBIB HSP90AB1 STK10 HSPA1B CCT8 NF2 ARPC1B ACTG1 CFL1 LYN YES1 LIMK1 PTK2 DGAT1 DSN1 B4GALT1 HEXB FAF2 FABP5 PIK3CA PLCG1 SOS1 ARHGAP45 NEU1 CTSA VNN1 MOSPD2 fliC GLB1 TLR10 IRAK4 TLR5 MYD88 TICAM2 LY96 ELMO1 CRK TICAM1 CD14 TLR4 CAB39 AMPD3 APRT PNP GYG1 LAMTOR2 LAMTOR1 DBNL LAMTOR3 PKP1 NOD1 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 TAB2 TAB1 UBE2V1 LPO MPO ANXA2 AAMP VCL CYFIP1 NCKAP1 NCF1 MEF2A NCF2 MEF2C SNAP23 NCF4 ELK1 RPS6KA3 BRK1 RPS6KA5 RPS6KA2 RPS6KA1 STBD1 CYBB CYBA VAV2 PIK3R2 NCKAP1L WASF1 WASF2 RELB UBA3 MAP3K14 UBE2M BAIAP2 ABI2 ABI1 TIFA ALPK1 ITGAL ATF2 CTNNB1 UNC93B1 SLC2A5 PANX1 hly OTUD5 NLRX1 UBA7 UBE2D2 UBE2D3 NLRC5 TNFAIP3 UBE2L6 HERC5 TBK1 RNF216 PCBP2 IKBKE ATG5 ISG15 ATG12 CYLD RNF125 IRF3 TRAF3 TAX1BP1 PIN1 UBE2K PROS1 PRCP CASP2 CD177 FGB FGA FGG BIRC2 BIRC3 GUSB SERPING1 HPSE ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR MAPKAPK3 MAP2K7 ECSIT IRAK3 PELI3 PELI2 MAPK9 MAP3K1 MAPK10 EEF1A1 MRE11 EEF2 PPP2R1B MGST1 NOS1 CYB5R3 MAP2K6 GRAP2 PPP2R5D FGR PECAM1 ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PLPP5 APOB PLPP4 NOS3 PDPK1 GSTP1 PTPN11 P2RX7 AOC1 P2RX1 PTPN6 CALM1 MAPK8 KLRK1 fljB EEA1 KIR3DS1 prgJ FCER1A NCR2 MS4A2 KIR2DS2 KIR2DS4 KIR2DS5 ITK CD300LB TREM1 TXK SIGLEC16 SIGLEC15 CD300E NLRP1 KLRC2 KLRD1 AIM2 CARD9 JUN TXN CDK13 GPI ARG1 FOS KCNAB2 CASP1 APAF1 NLRC4 CYFIP2 AHCYL1 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 TXNIP V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 MEFV BIN2 PLCG2 CD19 HMOX1 ATG7 GSDMD V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV SIKE1 V5-4 V5-1 SYK V5-6 HCK IL1B IGLV3-19 WAS HSP90AA1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 IFNA13 V4-1 IFNA14 IFNA16 IGKV1-5 IFNA17 MYO9B PPP2R1A IFNA10 IGLV BTRC PRKACA MUC5AC IGHG3 PYCARD CEP290 IGHG4 IGHG1 IGHG2 V3-4 SKP1 V3-3 V3-2 IGKV1D-39 IGKV1D-33 FBXW11 TUBB MUC12 MUC15 ABL1 IFNA21 MUC3A IGHV4-59 DYNLL1 GPR84 MUC3B IGLV2-11 NCKIPSD MUC16 MUC17 MUC19 IGLV1-40 MUC20 IGLV1-47 IGLV6-57 MUC21 MLEC IGLV2-14 UBA52 IGLV1-44 IGKV3-15 MUC5B NLRP3 IGKV3-11 V2-8 IFNA5 IFNA4 IGLV7-43 IGKV1D-16 CUL1 HLA-H IFNA7 IGKV1D-12 HLA-B HLA-C IFNA6 IGLV1-51 IGLV2-23 IGKV3-20 HLA-E UBB IFNA2 FCN1 IGHV4-34 HBB FCN2 IGHV1-2 FCN3 CD81 IGHV4-39 UBC C4BPA FCGR3A C4BPB PSTPIP1 IFNA8 RPS27A C4A IGKV2-29 MASP1 IGKV2-28 CPB2 IGLC3 IGLC1 CFH IGLC2 CFI V1-9 C4B_2 C2 DYNC1H1 V1-7 VTN V1-5 C6 V1-3 C7 RAC1 C9 C8B TUBB4B IGKV3D-20 C8A C8G MYH2 MBL2 CR2 IGKV2-30 RBSN CR1 IGHV2-70 CD46 IGHV2-5 IGHV3-48 C1QB IGLV3-1 CRP C1QA COLEC11 IGKV1-39 COLEC10 C1S IGKV1-33 C1R FCGR1A CPN2 WASF3 IGHV3-53 CPN1 CFHR2 IGLC7 MYO10 CFHR1 CFHR4 IGKV5-2 DOCK2 CFHR3 IGLC6 DOCK1 FCGR2A CFHR5 SUGT1 C1QC LAT2 IGHE B2M HLA-A IFNB1 LCK CAPZA1 CAPZA2 MUC1 POLR2E POLR2F MUC2 POLR2H TANK POLR2K MUC7 ALOX5 POLR2L MUC4 MUC6 FRK UBE2D1 AP2A2 CAT RETN DERA PGM2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 HVCN1 PSMD1 NPC2 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 HSP90B1 PSME1 PSME2 PSMD10 PSMB11 PSMD12 FUCA2 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 QSOX1 PSMB1 AHSG PSMF1 PAK2 TNIP2 DNAJC3 PSMB8 PSMB9 PRKCE SEM1 PSMC5 PSMC6 PSMC3 RASGRP2 PSMC4 RASGRP1 PSMC1 PSMC2 RAP1B PPIE RAP1A RAF1 CST3 MUCL1 TNFRSF1B CASP8 RIPK1 TRAF2 FADD CDC34 APP BCL10 PRKCSH MAGT1 C3AR1 HMOX2 DDOST FPR1 FPR2 C3 C5 SLCO4C1 ATP8A1 PPBP MUC13 DSP ATP11B CKAP4 ATP11A DSG1 CCR6 SLC15A4 CCR2 ATP8B4 TCIRG1 F2 DYNC1LI1 PLA2G6 GNS PTAFR CXCR1 CXCR2 SERPINA1 ARPC1A ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 SAA1 VAMP8 ATP6V0D1 ATP6V0D2 TRPM2 ATP6V0A2 ATP6V0A4 PAFAH1B2 ATP6V1C1 ATP6V0A1 PTPN4 ATP6V1C2 C5AR2 C5AR1 RAB3A SLC44A2 ATP6V0B RAB31 ANO6 PSAP FTL RAB5B RAB5C ATP6V0C RAB6A AP1M1 TXNDC5 ATP6V1G3 ATP6V0E2 TRAPPC1 ARPC4 ARPC5 CXCL1 ARPC2 ARPC3 ATP6V1A ATP6V1D ATP6V1F SNAP29 ACTR2 SLC2A3 DHX58 TKFC ATP6V1B2 ATP6V1B1 NFATC2 RAB10 CAND1 MYO1C STOM RAB14 RAB18 FTH1 TBC1D10C CAPN1 PRSS2 ADAM10 ADAM8 PSEN1 NCSTN ELANE GSDME SURF4 CTSS MYO5A RAB27A MMP25 TEC CTSL CTSK TIMP2 CTSG CTSZ CTSD CTSB GDI2 CD3G MMP8 MMP9 CTSC CD44 SOCS1 CD59 BCL2 CD55 BCL2L1 CRCP CGAS DDX41 LRRFIP1 TRIM21 PGLYRP4 IRF7 PGLYRP3 TRIM56 DEFB105B PRKDC PGLYRP2 NLRC3 LEAP2 IFI16 DEFB1 DHX36 STAT6 CLU XRCC6 HTN1 DEFB109B POLR3GL XRCC5 HTN3 S100A7A TREX1 BPIFA1 ACTR10 POLR3A GNLY STING1 RAB9B BPIFA2 POLR3B EPPIN POLR3C PGLYRP1 POLR3D ATP7A POLR3E PRSS3 POLR3F CAMP POLR3G DEFB106B POLR3H DEFB119 POLR3K TRIM32 DCD DEFB118 DEFB117 DEFB116 PIK3R4 SLC11A1 DEFB115 PIK3CB DEFB114 RNASE6 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 BPI PRTN3 DEFB130A DEFB130B DEFB4B S100A9 S100A8 TLR2 GAB2 COPB1 LTF S100A7 REG3A DEFB103B DEFB129 TLR9 PIK3C3 DEFB131A DEFB128 DEFB127 DEFB126 ITLN1 DEFB125 DEFB124 DEFB123 REG3G DEFB121 DEFB107B ART1 PDZD11 SSA1 RNASE8 SSA2 RNASE7 DEFA1B PI3 IGF2R CHGA DEFB104B DEFA6 DEFA4 DEFA5 PLA2G2A DEFB136 DEFA3 DEFB135 DEFB134 DEFB133 env DEFB108B LYZ DEFB132 TOMM70 DEFB108C ATOX1 BPIFB2 DNM1 CD4 DNM2 BPIFB1 PRDX6 BPIFB4 DNM3 BPIFB6 SEMG1 LCN2 HSPA8 MYH9 WASL PIK3R1 IQGAP1 CDC42 PAK1 TSPAN14 SPTAN1 NCK1 TLR8 CNPY3 LGMN LTA4H ZBP1 NLRP4 DTX4 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 PRKCD MAPK7 MAPKAPK2 CLEC10A ICAM2 ICAM3 CLEC4A CLEC4E CARD11 CLEC7A NFATC3 CLEC6A MALT1 CREB1 MAPK14 RASGRP4 MAPK11 PRKCQ HSPA1A IDH1 PRKACG PRKACB S100A1 HMGB1 TIRAP mip BTK porB TLR6 HSPA6 CD36 CASP4 PELI1 ACAA1 ITCH SLC27A2 TLR7 IMPDH1 IMPDH2 CCT2 ROCK1 BST2 HRAS NFKBIA RELA NFKB2 NRAS CFD GZMM RAC2 CFB PLD2 RHOA PPP3CA PPP3CB MAP3K7 LGALS3 HYDROXYCARBOXYLIC ACID-BINDING RECEPTORS%REACTOME%R-HSA-3296197.2 Hydroxycarboxylic acid-binding receptors HCAR1 HCAR2 HCAR3 SULFUR AMINO ACID METABOLISM%REACTOME%R-HSA-1614635.6 Sulfur amino acid metabolism MTRR MRI1 CSAD ADO CBS MPST ENOPH1 GOT1 TSTD1 GOT2 BHMT2 SUOX MTAP CTH ETHE1 AHCY CDO1 GADL1 APIP MTR CBSL SQOR TST TXN2 SLC25A10 BHMT MAT1A ADI1 SIGNALING BY FGFR2 IIIA TM%REACTOME DATABASE ID RELEASE 76%8851708 Signaling by FGFR2 IIIa TM NCBP2 POLR2L GTF2F1 FGF1 GTF2F2 FGF2 FGFR2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I NCBP1 POLR2J POLR2K PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS%REACTOME%R-HSA-73817.5 Purine ribonucleoside monophosphate biosynthesis IMPDH1 LHPP IMPDH2 PFAS PAICS ATIC GART PPAT GMPS ADSS1 ADSL ADSS2 REGULATION OF PYRUVATE DEHYDROGENASE (PDH) COMPLEX%REACTOME DATABASE ID RELEASE 76%204174 Regulation of pyruvate dehydrogenase (PDH) complex PDHB DLAT PPARD PDHA2 PDHX PDHA1 RXRA GSTZ1 PDPR DLD PDK4 PDK3 PDK2 PDK1 PDP1 PDP2 YAP1- AND WWTR1 (TAZ)-STIMULATED GENE EXPRESSION%REACTOME%R-HSA-2032785.3 YAP1- and WWTR1 (TAZ)-stimulated gene expression WWTR1 HIPK2 NPPA TBX5 NKX2-5 CCN2 KAT2B TEAD1 TEAD2 HIPK1 TEAD3 TEAD4 GATA4 YAP1 SIGNALLING TO STAT3%REACTOME DATABASE ID RELEASE 76%198745 Signalling to STAT3 NGF STAT3 NTRK1 TRANSPORT OF BILE SALTS AND ORGANIC ACIDS, METAL IONS AND AMINE COMPOUNDS%REACTOME%R-HSA-425366.3 Transport of bile salts and organic acids, metal ions and amine compounds SLC44A1 RUNX1 SLC13A1 SLC31A1 SLC13A2 SLC30A7 SLC16A1 SLC30A6 SLC13A3 SLC13A4 SLC30A8 SLC30A3 SLC30A2 RHAG SLC30A5 SLC47A2 SLC30A1 SLC47A1 SLC5A11 SLC30A10 SLC5A3 SLC41A2 SLC41A1 SLC6A20 SLC13A5 SLC6A6 SLC6A9 SLC6A1 EMB SLC18A1 SLC18A2 SLC2A13 SLC6A15 SLC39A4 SLC6A13 SLC39A10 SLC39A14 SLC6A19 SLC6A18 SLC22A6 SLC6A14 SLC11A2 RHBG SLC5A7 SLC6A12 SLC6A11 SLC39A6 SLC10A6 SLC16A7 SLC39A5 SLC16A8 SLC39A8 SLC39A7 SLC39A2 SLC22A8 SLC16A3 SLC22A7 SLC39A1 CP SLC39A3 SLC44A5 SLC6A5 SLC11A1 SLC44A3 SLC44A4 SLC44A2 SLC40A1 BSG SLC22A4 SLC6A2 RHCG SLC22A3 RSC1A1 SLC6A3 SLC22A15 SLC22A12 SLC22A11 SLC22A5 SLC22A16 HEPH SLC22A18 SLC22A2 SLC22A1 SLC14A1 SLC14A2 SLC6A7 EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4%REACTOME DATABASE ID RELEASE 76%9630791 Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 CDKN2A CDK4 B-WICH COMPLEX POSITIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-5250924.2 B-WICH complex positively regulates rRNA expression POLR2E POLR2F POLR2H H2AX H2AB1 POLR2K H2AC19 POLR2L ACTB H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 BAZ1B H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H DDX21 TAF1D H3C15 TAF1B TAF1C TAF1A H2BS1 SF3B1 GSK3B H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 DEK MYBBP1A H2AC20 ERCC6 REGULATION OF PTEN GENE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%8943724 Regulation of PTEN gene transcription HDAC3 TP53 CBX8 CBX6 CBX4 CBX2 BMI1 NR2E1 PPARG MAPK1 MAPK3 KDM1A CHD4 CHD3 RNF2 HDAC5 HDAC7 REST HDAC2 HDAC1 MTA1 RBBP4 PHC2 PHC1 RING1 RBBP7 MTA2 MTA3 MBD3 EZH2 PHC3 RPTOR RCOR1 MLST8 EED SLC38A9 GATAD2B GATAD2A SNAI1 SNAI2 MECOM EGR1 ATN1 MAF1 SUZ12 MTOR RRAGA JUN RRAGC RHEB RRAGB SALL4 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 ATF2 DEFECTIVE GSS CAUSES GSS DEFICIENCY%REACTOME DATABASE ID RELEASE 76%5579006 Defective GSS causes GSS deficiency GSS DEFECTIVE SLCO1B1 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619110.2 Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B1 TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY%REACTOME%R-HSA-5676594.1 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway LTA TRAF2 MAP3K14 BIRC2 TNFSF13B BIRC3 TNFSF11 TRAF3 TNFRSF12A TNFSF12 TNFRSF11A TNFRSF13C TNFSF14 CD40LG LTBR LTB CARBOXYTERMINAL POST-TRANSLATIONAL MODIFICATIONS OF TUBULIN%REACTOME%R-HSA-8955332.1 Carboxyterminal post-translational modifications of tubulin TTLL10 TTLL11 TUBB6 TTLL12 TUBB8 TUBA3E TUBB3 TUBB1 TUBB8B TUBA3D TPGS1 TUBA3C TPGS2 LRRC49 TTLL7 TTLL6 TTLL5 AGBL5 TTLL4 AGBL4 TTLL3 TTLL2 AGBL1 TTLL1 AGBL3 TTLL9 AGBL2 TTLL8 AGTPBP1 NICN1 VASH2 VASH1 TUBA1A TTLL13P TUBA1C TUBB4B TUBA1B TUBB4A TTL TUBB2B TUBB2A SVBP RESOLUTION OF ABASIC SITES (AP SITES)%REACTOME%R-HSA-73933.2 Resolution of Abasic Sites (AP sites) POLD2 XRCC1 POLE4 POLE2 POLE3 POLB PCNA MPG PNKP RFC5 RFC3 RFC4 RFC2 OGG1 POLE NTHL1 TDG LIG1 MBD4 PARP1 RFC1 PARP2 SMUG1 LIG3 NEIL2 RPA1 RPA2 NEIL1 PARG APEX1 RPA3 ADPRS POLD3 FEN1 POLD4 POLD1 SIGNALING BY KINASE DOMAIN MUTANTS OF KIT%REACTOME DATABASE ID RELEASE 76%9669933 Signaling by kinase domain mutants of KIT KIT FRS-MEDIATED FGFR3 SIGNALING%REACTOME%R-HSA-5654706.3 FRS-mediated FGFR3 signaling HRAS FGF1 FGF2 FRS3 FGF4 SOS1 NRAS PTPN11 FGF9 FGF20 FGF23 FRS2 FGF16 FGF18 SIGNALING BY NOTCH1 T(7;9)(NOTCH1:M1580_K2555) TRANSLOCATION MUTANT%REACTOME DATABASE ID RELEASE 76%2660825 Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant JAG1 JAG2 ADAM10 ADAM17 DLL1 NOTCH1 DLL4 O2 CO2 EXCHANGE IN ERYTHROCYTES%REACTOME%R-HSA-1480926.2 O2 CO2 exchange in erythrocytes CYB5R2 RHAG CYB5R1 CYB5R4 HBB CYB5RL HBA2 CA1 CA2 CA4 SLC4A1 AQP1 LOCALIZATION OF THE PINCH-ILK-PARVIN COMPLEX TO FOCAL ADHESIONS%REACTOME DATABASE ID RELEASE 76%446343 Localization of the PINCH-ILK-PARVIN complex to focal adhesions ILK PARVA PXN ITGB1 REGULATION OF LOCALIZATION OF FOXO TRANSCRIPTION FACTORS%REACTOME%R-HSA-9614399.1 Regulation of localization of FOXO transcription factors FOXO3 YWHAZ FOXO1 YWHAB YWHAQ AKT2 YWHAG SFN FOXO6 AKT1 AKT3 FOXO4 SYNTHESIS OF PG%REACTOME DATABASE ID RELEASE 76%1483148 Synthesis of PG PLD1 CDS2 PLD6 PLD2 PGS1 PTPMT1 PLD4 PLD3 KERATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022854.1 Keratan sulfate biosynthesis ST3GAL3 CHST6 LUM OMD KERA OGN FMOD B4GAT1 ST3GAL4 ST3GAL1 ST3GAL2 B4GALT2 B4GALT3 B3GNT7 B3GNT4 B3GNT3 CHST1 ST3GAL6 B3GNT2 B4GALT6 CHST5 B4GALT4 B4GALT1 CHST2 B4GALT5 SLC35D2 PRELP ACAN BIOSYNTHESIS OF PROTECTIN AND RESOLVIN CONJUGATES IN TISSUE REGENERATION (PCTR AND RCTR)%REACTOME DATABASE ID RELEASE 76%9026766 Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR) LTC4S PTK6 REGULATES PROTEINS INVOLVED IN RNA PROCESSING%REACTOME%R-HSA-8849468.1 PTK6 Regulates Proteins Involved in RNA Processing PTK6 SFPQ KHDRBS1 KHDRBS2 KHDRBS3 BLOCKAGE OF PHAGOSOME ACIDIFICATION%REACTOME%R-HSA-9636467.1 Blockage of phagosome acidification ATP6V1H ptpA FGFR2 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 76%1839126 FGFR2 mutant receptor activation POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2F1 FGF1 GTF2F2 FGF2 FGFR2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 CHAPERONIN-MEDIATED PROTEIN FOLDING%REACTOME%R-HSA-390466.3 Chaperonin-mediated protein folding HDAC3 CCNE2 CCNE1 DCAF7 TP53 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 RGS9 RGS6 RGS7 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 XRN2 CSNK2B GAPDHS FKBP9 GNG10 GNG12 GNG11 GNG13 ACTB CCT6A GNB2 GNAQ GNB1 GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 TUBA1A FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 GBA GNA14 TUBA3E AP3M1 GNG3 GNA15 TUBA3D GNG2 CCT2 TUBA3C TUBA4A GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 CCT7 TUBB4B TUBB4A DEGRADATION OF GABA%REACTOME%R-HSA-916853.2 Degradation of GABA ABAT ALDH5A1 INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670095.2 Inhibition of DNA recombination at telomere H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 POLR2A H2BC8 POLR2B H2BC5 POLR2C POLR2D H2BC3 POLR2E POLR2F H2BC1 POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC20 H2AC19 POLR2L H2AC14 H2BC21 H2BU1 H3-3B DAXX H2AC8 ATRX ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 G ALPHA (I) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 76%418594 G alpha (i) signalling events HTR1F PLCB3 HTR1D PLCB1 PLCB2 HTR1B OPN5 PPP3R1 CXCL10 PYY CXCL11 KPNA2 CXCL12 RLN3 NMUR2 NMUR1 CXCL6 CXCL9 GNAT1 CXCL8 PLCB4 RGSL1 PPP1R1B CCL4L2 RGS4 CXCL1 RGS5 MAPK1 RGS3 RGS1 CXCL3 RGS8 CXCL2 PCP2 CXCL5 GNAI3 HEBP1 PRKX GPSM1 GPER1 GNAI1 GPSM2 BDKRB2 GNAI2 PDE4B PDE4A BDKRB1 GPSM3 PDE4D INSL5 PDE4C RGS18 RGS17 NPY5R RGS19 RGS14 RGS13 OPRM1 RGS16 SSTR1 RGS21 SSTR2 RGS20 PPP2R1A ADRA2C RGS22 SSTR3 RGS10 ADRA2B RGS12 SSTR4 ADRA2A PRKACA SSTR5 CORT CX3CR1 NPY4R OPRL1 CNR2 P2RY4 CNR1 CCL5 PRKCG GNAZ CCL4 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CDK5 HTR5A APLN POMC OPN1SW SST ACKR3 PRKAR2B SRC CAMKK1 CAMKK2 NBEA PPP3CC GRK2 GNAL PPP2R1B RGS9 RGS6 RGS7 PLA2G4A PPP2R5D APP RXFP4 RRH PDE1B PDE1A ITPR1 GNG10 ITPR2 RXFP3 ITPR3 PPP2CA GNG12 PPP2CB C3AR1 GNG11 OXER1 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GPR37L1 PDYN GNGT1 GNGT2 AGTR2 LPAR1 FPR1 CALM1 LPAR2 LPAR3 FPR3 FPR2 C3 C5 GALR3 GALR2 GNA14 GALR1 NPBWR1 PENK GNG3 NPBWR2 GNA15 PPY GNG2 CCR10 GNG5 GNG4 GNG7 CCR1 GNA11 GPR17 GNG8 PPBP LPAR5 RGS11 NMS GPR183 PNOC NMU GPR18 PTGDR2 PRKCD PRKCA CX3CL1 CAMK2B CAMK2D CAMK2A OPN1LW CCR9 CAMK2G CCR8 CCR7 CREB1 CCR6 CAMK4 CCR5 CCR4 PPP1CA CCR3 OXGR1 CCR2 ANXA1 GPR37 GPR31 GAL OPN1MW PRKACG PRKACB RGR OPRD1 ADCY9 CCL13 PRKAR1B NPB PRKAR1A PRKAR2A PTGER3 CXCR5 GNAS CXCR4 CXCR6 NPW CXCR1 CXCR3 NPY PDE1C CXCR2 ADCY4 RHO CCL19 ADCY3 ADCY2 ADCY1 ADCY8 CCL16 ADCY7 CCL25 ADCY6 P2RY12 ADCY5 P2RY13 CCL21 CCL20 P2RY14 GPR55 AGT TAS2R60 TAS2R7 MT-RNR2 TAS2R9 TAS2R40 SAA1 TAS2R8 TAS2R41 TAS2R20 CCL28 TAS2R42 CCL27 TAS2R43 TAS2R45 PF4 TAS2R46 CHRM2 GRM3 GRM2 CHRM4 GRM4 GRM7 NPY2R GRM6 GRM8 PMCH TAS1R2 CXCL13 TAS2R1 CXCL16 TAS1R1 TAS2R3 TAS1R3 ADORA3 TAS2R5 TAS2R4 TAS2R50 ADORA1 GABBR2 CASR AHCYL1 GABBR1 TAS2R30 NPY1R TAS2R31 MTNR1A TAS2R10 TAS2R13 MTNR1B TAS2R14 APLNR TAS2R16 TAS2R38 SUCNR1 TAS2R39 GNAT3 TAS2R19 C5AR1 MCHR1 MCHR2 KNG1 HCAR2 HCAR3 HCAR1 PSAP HRH4 DRD3 DRD4 PPP3CA PPP3CB GNAT2 OPN3 HTR1E ATTENUATION PHASE%REACTOME DATABASE ID RELEASE 76%3371568 Attenuation phase CREBBP HSBP1 DNAJB1 HSPA1L HSF1 PTGES3 HSP90AA1 HSPA2 HSPA8 EP300 FKBP4 HSPA1B HSPA1A HSP90AB1 SIRT1 NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME%R-HSA-427359.2 SIRT1 negatively regulates rRNA expression SIRT1 TAF1D H3C15 TAF1B TAF1C TAF1A RRP8 H2BS1 H2AZ1 H2BC9 H2AZ2 SUV39H1 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 TNFR1-INDUCED NFKAPPAB SIGNALING PATHWAY%REACTOME%R-HSA-5357956.1 TNFR1-induced NFkappaB signaling pathway RACK1 TAB1 TNFRSF1A TRAF1 TRADD RIPK1 TRAF2 BIRC2 BIRC3 RNF31 XIAP TNF USP21 USP4 USP2 IKBKB CHUK RBCK1 IKBKG TNFAIP3 SHARPIN CYLD OTUD7B TAB3 MAP3K7 TAB2 HDR THROUGH SINGLE STRAND ANNEALING (SSA)%REACTOME DATABASE ID RELEASE 76%5685938 HDR through Single Strand Annealing (SSA) RHNO1 BLM ABL1 BRIP1 ERCC4 ERCC1 ATRIP ATM BARD1 RAD17 RAD9B ATR RAD9A BRCA1 EXO1 TOPBP1 RFC5 RAD52 RMI2 RFC3 RFC4 RFC2 RMI1 TOP3A WRN RBBP8 MRE11 RAD51 RPA1 RPA2 KAT5 NBN RAD50 RPA3 HUS1 RAD1 DNA2 CD163 MEDIATING AN ANTI-INFLAMMATORY RESPONSE%REACTOME DATABASE ID RELEASE 76%9662834 CD163 mediating an anti-inflammatory response PLK2 RHBDF2 MAPK14 ADAM17 CD163 FURIN MYH9 IL10 IL6 DEFECTIVE FACTOR IX CAUSES THROMBOPHILIA%REACTOME DATABASE ID RELEASE 76%9672383 Defective factor IX causes thrombophilia F9 F8 F10 CELL CYCLE, MITOTIC%REACTOME%R-HSA-69278.4 Cell Cycle, Mitotic PRKCB MAPK1 HSP90AA1 CEP57 YWHAE KPNB1 CETN2 CEP164 CCP110 PPP1CB PCM1 ACTR1A TUBA1A PPP2R1A KIF20A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 OFD1 PPP1R12A CEP135 BORA FBXW11 TUBB CEP131 ABL1 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 KIF18A AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN IST1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 JAK2 TUBB4B TUBB4A NEDD1 CENPJ KIF23 ALMS1 CDK1 CEP41 CEP43 KIF2A UBE2I KIF2C KIF2B RPS27 SUMO1 CABLES1 CENPE WEE1 CCNH H2AX H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B CDK7 H3C8 H2AC8 MNAT1 H2AC6 ANAPC15 H2AC7 ANAPC16 ANAPC7 H2BC17 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 ANAPC10 H2BC14 ANAPC11 CDC25A H2AJ CDC23 UBE2S H2BC15 CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 H3C15 BANF1 PSMD3 NUP210 PSMD1 PSMA5 RBBP4 NUP93 PSMA6 PSMA3 H2BS1 POM121 PSMA4 NUP205 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 H2AZ2 PSMD10 AAAS H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 POM121C PSMD14 NUP85 H2BC3 PSMD13 TPR NUP88 PSMA7 H2BC1 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 H2AC20 PSMB4 NUP153 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NUP62 NDC1 ESCO1 CDCA5 NUP133 PDS5B ESCO2 PDS5A WAPL NUP50 NUP54 TUBB6 NEK9 TUBB3 NEK6 NUP42 TUBB1 NEK7 NUP43 VRK1 RAE1 CTDNEP1 RANBP2 CNEP1R1 RAN CDCA8 NUP35 SKA1 CSNK2A1 SKA2 NUP37 ANKLE2 CSNK2A2 TUBA4B CSNK2B NUF2 NUDC INCENP CENPA CENPC CENPT CENPU TUBA8 CENPH TUBA1C CENPI H3-4 TUBA1B TAOK1 CENPK CENPL CENPM TUBB2B TUBB2A CENPN CENPO HSP90AB1 CENPP CENPQ CENPS TUBAL3 TUBA3E TUBA3D TUBA3C CLIP1 MAD1L1 NDC80 SPDL1 RANGAP1 LYN NSL1 CDC20 PPP1CC KNL1 DSN1 RCC2 ZWINT AHCTF1 NDEL1 AKT3 LPIN1 LPIN2 LPIN3 MIS12 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 MCM7 MCM8 SGO1 SKP2 SGO2 MCM3 MCM4 MCM5 MCM6 PMF1 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 BUB1 SIRT2 E2F6 GINS1 GINS2 CDC45 GINS3 GINS4 DHFR USO1 AKT2 MAU2 NIPBL LBR EMD RRM2 LEMD3 PPP2R2A RAB1A PPME1 PHLDA1 GTSE1 FKBPL RAB1B CDC25C VPS4A CDC25B TUBGCP2 HMMR PKMYT1 TPX2 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 FBXL7 LIN54 FOXM1 MYBL2 LIN52 TUBG2 MZT2B CDC7 MZT2A NME7 LIN37 LIN9 LCMT1 CDK11A FBXL18 PPP2R3B CDK11B MZT1 CENPF CDKN1C GOLGA2 RB1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CCND1 POLE CDK4 E2F1 LIG1 E2F2 RFC1 E2F3 MYC CDKN2B ZW10 POLD3 POLD4 POLD1 POLD2 POLE4 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 RAB2A GORASP2 BLZF1 SEC13 NCAPG NCAPD2 SMC4 NCAPH SMC2 DYNC1I1 ITGB3BP CHMP4C CHMP4B CHMP4A KMT5A FEN1 DNA2 PPP2R1B PPP2R5E PPP2R5B PPP2R5A PPP2R5D CHMP2B PPP2R5C CHMP2A PPP2CA RFC5 PPP2CB RFC3 RFC4 RFC2 GORASP1 CHMP3 CHMP6 RPA1 CHMP7 RPA2 RPA3 DYNLL2 SMC3 TUBB8 SPAST TUBB8B LEMD2 CC2D1B RAD21 GSK3B STAG1 STAG2 SMC1A XPO1 AKT1 TNPO1 NUP214 PRKCA ARPP19 NCAPH2 NCAPG2 ENSA NCAPD3 CDC14A LMNB1 SET ESPL1 PTTG1 AURKB MASTL MCPH1 CDKN2D PPP2R2D CDKN2C EML4 NUMA1 CDKN1A CDKN1B CCNA2 CCNA1 CCNE2 CCNE1 TP53 CDKN2A CDK2 RBX1 PCNA TOP2A MAX E2F5 RCC1 BUB1B BUB3 MAD2L1 CKS1B GMNN FBXO5 DYRK1A MCM10 TK1 DBF4 TYMS RPA4 RBL2 RBL1 BIRC5 E2F4 PTK6 DEFECTIVE FACTOR XII CAUSES HEREDITARY ANGIOEDEMA%REACTOME%R-HSA-9657688.1 Defective factor XII causes hereditary angioedema F2 KLKB1 F12 HEME DEGRADATION%REACTOME DATABASE ID RELEASE 76%189483 Heme degradation GSTA1 HMOX2 ALB UGT1A4 BLVRB BLVRA ABCC2 UGT1A1 FABP1 SLCO1B1 ABCC1 ABCG2 SLCO1B3 HMOX1 SMAD2 3 MH2 DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%3315487 SMAD2 3 MH2 Domain Mutants in Cancer SMAD4 SMAD3 SMAD2 PONATINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702614 ponatinib-resistant FLT3 mutants FLT3 INTERLEUKIN-3, INTERLEUKIN-5 AND GM-CSF SIGNALING%REACTOME%R-HSA-512988.5 Interleukin-3, Interleukin-5 and GM-CSF signaling CSF2 SHC1 CRK PIK3CA SOS1 IL2RA SYK FYN HCK TEC BLNK VAV1 INPP5D LYN YES1 INPPL1 CRKL IL5RA STAT5A IL2 CSF2RB STAT5B YWHAZ IL3 IL2RG CSF2RA IL5 PIK3CB IL2RB IL3RA PTPN11 PIK3CD PIK3R1 JAK2 PIK3R3 PRKACA RAPGEF1 JAK3 GAB2 PTPN6 CBL JAK1 PIK3R2 MYOCLONIC EPILEPSY OF LAFORA%REACTOME%R-HSA-3785653.3 Myoclonic epilepsy of Lafora EPM2A GYG1 UBB UBA52 UBC RPS27A PPP1R3C GYS1 NHLRC1 PHOSPHATE BOND HYDROLYSIS BY NTPDASE PROTEINS%REACTOME%R-HSA-8850843.4 Phosphate bond hydrolysis by NTPDase proteins ENTPD2 ENTPD1 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD5 ENTPD8 REGULATION OF SIGNALING BY NODAL%REACTOME%R-HSA-1433617.1 Regulation of signaling by NODAL ACVR1B ACVR2B ACVR2A CFC1 ACVR1C TDGF1P3 LEFTY2 TDGF1 DAND5 NODAL CER1 LEFTY1 DEFECTIVE SLC24A5 CAUSES OCULOCUTANEOUS ALBINISM 6 (OCA6)%REACTOME%R-HSA-5619036.1 Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6) MRNA DECAY BY 3' TO 5' EXORIBONUCLEASE%REACTOME DATABASE ID RELEASE 76%429958 mRNA decay by 3' to 5' exoribonuclease DIS3 HBS1L TTC37 NT5C3B EXOSC7 SKIV2L EXOSC6 DCPS EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 WDR61 FGFR4 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 76%1839128 FGFR4 mutant receptor activation FGFR4 TELOMERE EXTENSION BY TELOMERASE%REACTOME DATABASE ID RELEASE 76%171319 Telomere Extension By Telomerase CCNA1 RTEL1 NOP10 ANKRD28 RUVBL1 PPP6C CDK2 RUVBL2 DKC1 PPP6R3 ACD SHQ1 NHP2 PIF1 TINF2 TERF1 TERF2 TERT WRAP53 POT1 TERF2IP GAR1 CCNA2 WNT5:FZD7-MEDIATED LEISHMANIA DAMPING%REACTOME%R-HSA-9673324.1 WNT5:FZD7-mediated leishmania damping RAC1 DVL1 JUN FZD7 DVL3 WNT5A MAPK8 NOXO1 NOXA1 DVL2 CYBA NOX1 ARACHIDONATE PRODUCTION FROM DAG%REACTOME%R-HSA-426048.3 Arachidonate production from DAG ABHD6 MGLL ABHD12 DAGLB DAGLA TRANSLESION SYNTHESIS BY POLH%REACTOME DATABASE ID RELEASE 76%110320 Translesion Synthesis by POLH RFC5 UBB RCHY1 RFC3 UBC RFC4 RFC2 RPS27A VCP RFC1 NPLOC4 SPRTN PCNA RPA1 UBA52 RPA2 RPA3 UFD1 POLH HDR THROUGH HOMOLOGOUS RECOMBINATION (HRR)%REACTOME DATABASE ID RELEASE 76%5685942 HDR through Homologous Recombination (HRR) RHNO1 POLD2 BLM POLE4 BRIP1 POLE2 POLE3 ATRIP ATM BARD1 PCNA RAD17 RAD9B ATR RAD9A BRCA1 EXO1 TOPBP1 RFC5 RMI2 RFC3 MUS81 RFC4 RFC2 SLX4 EME1 RMI1 EME2 GEN1 TOP3A SLX1B SPIDR WRN RBBP8 RPA1 CHEK1 RPA2 RAD50 RPA3 RAD1 POLH UBA52 UBB RTEL1 UBC POLK POLE RPS27A BRCA2 RAD51AP1 RFC1 XRCC2 XRCC3 PALB2 RAD51D MRE11 RAD51 KAT5 NBN RAD51B HUS1 POLD3 RAD51C POLD4 DNA2 POLD1 WNT MEDIATED ACTIVATION OF DVL%REACTOME%R-HSA-201688.1 WNT mediated activation of DVL CSNK2A1 DVL1 CSNK2A2 DVL3 CSNK2B CSNK1E DVL2 PIP5K1B MICROBIAL MODULATION OF RIPK1-MEDIATED REGULATED NECROSIS%REACTOME%R-HSA-9686347.1 Microbial modulation of RIPK1-mediated regulated necrosis MLKL CRMA 3a RIPK3 NS SPI-2 CASP8 UL36 RIR1 RIPK1 DEFECTIVE SLC6A5 CAUSES HYPEREKPLEXIA 3 (HKPX3)%REACTOME DATABASE ID RELEASE 76%5619089 Defective SLC6A5 causes hyperekplexia 3 (HKPX3) SLC6A5 RUNX3 REGULATES YAP1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951671.1 RUNX3 regulates YAP1-mediated transcription CCN2 WWTR1 TEAD1 TEAD2 TEAD3 TEAD4 RUNX3 YAP1 REGULATION OF RUNX3 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 76%8941858 Regulation of RUNX3 expression and activity CBFB CDKN2A MDM2 SMURF2 EP300 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TGFB1 SMURF1 RUNX3 SRC ANTI-INFLAMMATORY RESPONSE FAVOURING LEISHMANIA PARASITE INFECTION%REACTOME%R-HSA-9662851.1 Anti-inflammatory response favouring Leishmania parasite infection V1-20 GPR15 IGKV2D-40 IGHV3-11 IGHV3-13 GPR27 GPR25 GPR20 RLN2 IGHV1-46 RLN3 ADM PTH1R IGHV IL10 LPG1G2 V5-4 V5-1 SYK GPR32 PTH2R FYN V5-6 HCK IGLV3-19 RAMP2 RAMP3 GPR45 PTH GNAI3 PRKX GNAI1 GNAI2 IGLV3-25 INSL3 IGLV3-27 IGKC IGLV3-21 TSHB GPR150 PTGIR V4-6 V4-2 V4-1 AVPR2 IGKV1-5 SCTR GCG GHRH ADM2 RAMP1 IGLV PRKACA IGHG3 IGHG4 ADORA2A IGHG1 ADORA2B IGHG2 GGT1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 DPEP2 DPEP1 IAPP DPEP3 GNAZ CALCA CALCB CALCRL IGHV4-59 GPR83 GPR84 IGLV2-11 CALCR IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 TSHR IGKV3-15 IGKV3-11 POMC V2-8 GGT5 CD163 IGLV7-43 IGKV1D-16 IGKV1D-12 IL6 IGLV1-51 IGLV2-23 IGKV3-20 GLP1R PRKAR2B IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RHBDF2 GLP2R IGKV3D-20 GIP CRH ADAM17 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 PTH2 PTHLH IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 FCGR2A VIP CD3G FURIN FGR HTR4 RXFP1 ITPR1 RXFP2 GNG10 ITPR2 ITPR3 HTR6 HTR7 GNG12 GNG11 GNG13 GNB2 PTGDR GNB1 TAAR8 GNB4 TAAR9 TAAR6 GNB3 TAAR5 MYH9 TAAR2 GNB5 TAAR1 GNGT1 GNGT2 LHB CALM1 ADCYAP1 ADCYAP1R1 MC2R GNG3 GNG2 CGA GNG5 GNG4 GNG7 GNG8 MC1R LYN YES1 MC4R CREB1 MAPK14 GPR39 FSHB PLK2 GPBAR1 MC3R ADRB3 PLCG1 PRKACG FSHR PRKACB AVP PTGER4 NPSR1 ADCY9 PRKAR1B PRKAR1A PRKAR2A PTGER2 GNAS NPS ADCY4 ADCY3 ADCY2 ADCY1 GPHA2 ADCY8 ADCY7 ADCY6 ADCY5 P2RY11 MC5R GPHB5 CYSLTR1 CYSLTR2 VIPR1 VIPR2 LHCGR AHCYL1 SCT IGHV3-23 IGLV2-8 GPR176 IGKV1-16 GNAT3 IGKV1-17 IGKV1-12 ADRB1 IGHV3-7 ADRB2 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 TAAR3P V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 HRH2 V1-11 IGKV2D-30 GIPR V1-16 DRD1 V1-13 IGHV1-69 CRHR1 CRHR2 DRD5 GHRHR PLCG2 RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES%REACTOME%R-HSA-380270.2 Recruitment of mitotic centrosome proteins and complexes HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 CSNK1D HAUS6 HAUS5 TUBGCP5 CSNK1E TUBGCP6 TUBG1 TUBGCP3 DYNLL1 TUBGCP4 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 NME7 SDCCAG8 PAFAH1B1 CDK11A DYNC1I2 DCTN2 SSNA1 CDK11B DCTN3 MZT1 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 COOPERATION OF PDCL (PHLP1) AND TRIC CCT IN G-PROTEIN BETA FOLDING%REACTOME DATABASE ID RELEASE 76%6814122 Cooperation of PDCL (PhLP1) and TRiC CCT in G-protein beta folding CCT6B GNA14 GNG3 GNA15 GNG2 RGS9 RGS6 CCT2 GNG5 RGS7 GNG4 GNG7 GNA11 GNG8 CSNK2A1 CCT8 CCT5 CCT4 CSNK2A2 CSNK2B RGS11 GNG10 CCT7 GNG12 GNG11 GNG13 CCT6A GNB2 GNAQ GNB1 GNB4 PDCL GNB3 GNB5 GNGT1 GNGT2 CCT3 TCP1 QUIZARTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702620 quizartinib-resistant FLT3 mutants FLT3 NECTIN NECL TRANS HETERODIMERIZATION%REACTOME%R-HSA-420597.2 Nectin Necl trans heterodimerization CADM1 NECTIN4 NECTIN3 PVR NECTIN2 NECTIN1 CADM3 NILOTINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9669926 Nilotinib-resistant KIT mutants KIT STRIATED MUSCLE CONTRACTION%REACTOME%R-HSA-390522.1 Striated Muscle Contraction MYBPC3 TPM4 MYBPC1 MYBPC2 TPM3 TNNC1 TNNC2 MYH3 TNNT1 TPM2 TNNT2 TPM1 TNNT3 MYH8 MYH6 TTN TNNI1 TNNI2 DMD TNNI3 ACTN2 DES TCAP VIM TMOD3 TMOD1 ACTN3 TMOD4 TMOD2 MYL4 MYL1 MYL2 MYL3 NEB CELL RECRUITMENT (PRO-INFLAMMATORY RESPONSE)%REACTOME%R-HSA-9664424.1 Cell recruitment (pro-inflammatory response) C3 GSDMD CASP1 SUGT1 IL18 NLRP3 IL1A IL1B CTSG C3AR1 NT5E RELA PSTPIP1 ENTPD1 NFKB2 ENTPD5 P2RX7 TXNIP P2RX4 PYCARD NFKB1 MEFV TXN HSP90AB1 HMOX1 SELECTIVE AUTOPHAGY%REACTOME DATABASE ID RELEASE 76%9663891 Selective autophagy TOMM22 NBR1 UBE2V1 CFTR MFN1 MFN2 ATM DYNC1LI1 DYNC1LI2 CSNK2A1 IFT88 CSNK2A2 CSNK2B TOMM70 PRKN HSP90AA1 SQSTM1 HSPA8 PRKAB2 PRKAA2 PRKAG1 MAP1LC3B PLIN3 PRKAG2 PLIN2 PRKAB1 PRKAG3 ATG5 ATG12 TOMM20 PINK1 DYNLL2 HSF1 TOMM40 HDAC6 PARK7 VDAC1 DYNC1I1 DYNLL1 VCP EPAS1 USP30 UBA52 DYNC1I2 TOMM7 TOMM5 TOMM6 UBB UBC RPS27A PCNT DYNC1H1 MTERF3 CETN1 ARL13B MAP1LC3A FUNDC1 PEX5 ULK1 UBE2N COPI-INDEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME DATABASE ID RELEASE 76%6811436 COPI-independent Golgi-to-ER retrograde traffic RAB6B DYNC1I1 DYNLL1 GALNT2 DYNC1LI1 DYNC1LI2 GALNT1 PAFAH1B3 PLA2G4A CAPZA3 PLA2G6 PAFAH1B2 RAB3GAP2 CAPZA1 CAPZA2 ACTR10 PAFAH1B1 DYNC1I2 DCTN2 RAB18 RAB3GAP1 DCTN3 BICD1 BICD2 CAPZB ACTR1A DYNC1H1 DCTN6 DCTN5 DCTN1 DCTN4 AGPAT3 DYNLL2 RAB6A NEGATIVE REGULATION OF THE PI3K AKT NETWORK%REACTOME DATABASE ID RELEASE 76%199418 Negative regulation of the PI3K AKT network PPP2R1B PPP2R5E STRN PPP2R5B PPP2R5A PPP2R5D PPP2R5C KIT FYN MAPK1 RHOG VAV1 MAPK3 PDGFB PPP2CA PPP2CB PDGFRB HGF ERBB2 ESR2 PTPN11 CD86 CD80 PPP2R1A PIK3R1 TRIB3 PIK3R2 INS TRAT1 PIK3AP1 EGF IER3 PIP5K1A PIP5K1B AKT1 PHLPP2 PHLPP1 PIK3CD RAC1 MET EREG BTC SRC AKT3 ESR1 TGFA GAB1 PIK3CA FLT3 LCK CD28 PIP5K1C AREG IRAK4 MYD88 NRG1 NRG2 PTEN NRG3 NRG4 IL1RL1 IL33 EPGN HBEGF EGFR AKT2 KLB IRS1 PDGFRA IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 THEM4 FGF23 RAC2 FGF22 INSR FLT3LG PIK3R3 FRS2 PIP4K2A GAB2 PIP4K2B IRAK1 FGF16 FGF19 FGF18 PIP4K2C FGFR4 TRAF6 FGF10 CD19 METABOLISM OF VITAMINS AND COFACTORS%REACTOME%R-HSA-196854.6 Metabolism of vitamins and cofactors PRKG2 PDZD11 CYB5R3 SHMT2 LRP8 HSP90AA1 GSTO2 GSTO1 NT5E APOB COQ2 NOS3 TCN1 SLC2A3 CALM1 ABCC1 BTD GCHFR MTRR GCH1 PTS LRP2 PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 TCN2 PARP8 AKT1 PRSS1 SHMT1 CD320 CTRB2 CTRB1 HSPG2 SLC23A2 SDC4 SLC23A1 SDC2 NADSYN1 SDC3 PNPO SLC19A3 NADK SLC19A2 IDH1 COQ9 GPC1 COQ7 GPC3 ACACB COQ6 GPC2 COQ5 GPC5 COQ3 GPC4 NAMPT CTRC MOCS2 GPC6 MOCS3 QPRT GPHN THTPA NADK2 NMRK2 NAXE NMRK1 RNLS SLC22A13 CD38 AOX1 NAXD NUDT12 SLC25A19 SDC1 PDSS2 PDSS1 CYB5A AGRN TPK1 MOCOS BST1 NMNAT3 NMNAT2 NMNAT1 VKORC1L1 UBIAD1 LRP1 PTGS2 RETSAT PLB1 TTR APOM RDH11 PTGIS TTPA LRAT BCO2 AKR1C1 BCO1 VKORC1 PANK4 RBP4 PANK2 CLPS AKR1C3 PANK3 AKR1B10 PANK1 RBP2 RBP1 PPCDC AKR1C4 LRP10 COASY SLC46A1 SLC5A6 PNLIP LRP12 SLC25A16 CYP8B1 VNN1 VNN2 PPCS FASN ENPP2 MMAB ENPP1 ENPP3 AASDHPPT CUBN MMADHC AMN APOA2 NNMT APOA1 APOA4 MMAA MMUT LMBRD1 DHFR2 LPL ALDH1L1 MTHFR MTHFS ALDH1L2 DHFR APOE MTHFD1L MTHFD1 LDLR MTHFD2 MTHFD2L GPIHBP1 MCCC2 SLC25A32 PC FOLR2 PRSS3 SLC19A1 PCCA HLCS MTR NAPRT APOC3 MCCC1 PCCB ACACA APOC2 PDXK ABCD4 SLC2A1 MMACHC SLC5A8 FLAD1 CBLIF SLC52A2 RFK SLC52A3 SPR ACP5 SLC52A1 ACTIVATED NTRK2 SIGNALS THROUGH PI3K%REACTOME%R-HSA-9028335.1 Activated NTRK2 signals through PI3K NTF4 PIK3R1 BDNF GAB1 PIK3CA NTRK2 INSULIN RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 76%77387 Insulin receptor recycling ATP6V1B2 ATP6V1B1 TCIRG1 ATP6V1G3 ATP6V0D1 ATP6V0E2 ATP6V0D2 ATP6V0A2 ATP6V0A4 ATP6V1C1 ATP6V0A1 ATP6V1H ATP6V1C2 ATP6V1A ATP6V1D ATP6V1F ATP6V0B INSR ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6AP1 ATP6V0C INS THE IPAF INFLAMMASOME%REACTOME DATABASE ID RELEASE 76%844623 The IPAF inflammasome NLRC4 fljB prgJ CASP1 fliC SIGNALING BY RNF43 MUTANTS%REACTOME%R-HSA-5340588.2 Signaling by RNF43 mutants RNF43 FZD8 WNT3A LRP5 FZD5 FZD6 LRP6 FZD4 THE RETINOID CYCLE IN CONES (DAYLIGHT VISION)%REACTOME DATABASE ID RELEASE 76%2187335 The retinoid cycle in cones (daylight vision) RLBP1 RBP3 OPN1SW AWAT2 OPN1LW OPN1MW DHRS3 G2 M DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 76%69473 G2 M DNA damage checkpoint RHNO1 BLM TP53 BRIP1 ATRIP ATM SUMO1 BRCC3 BARD1 WEE1 RAD17 RAD9B ATR RAD9A BABAM1 BABAM2 YWHAQ BRCA1 UIMC1 SFN YWHAH H2AX EXO1 TOPBP1 RFC5 RNF8 RMI2 NSD2 RFC3 H2BC21 RFC4 RFC2 YWHAE H2BU1 RMI1 TOP3A WRN RBBP8 H2BC17 H2BC12 H2BC13 RPA1 H3-4 CHEK1 H2BC14 RPA2 H2BC15 RAD50 YWHAG RPA3 H2BC11 RAD1 CDC25C HERC2 H2BS1 TP53BP1 H2BC9 H4C9 H2BC8 H2BC5 YWHAB H2BC3 H2BC1 RNF168 ABRAXAS1 CCNB1 YWHAZ MRE11 MDC1 KAT5 UBE2V2 NBN CDK1 PIAS4 HUS1 CHEK2 UBE2N DNA2 SIGNALING BY FGFR2 IN DISEASE%REACTOME%R-HSA-5655253.1 Signaling by FGFR2 in disease GAB1 PIK3CA PLCG1 SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 HRAS GTF2F1 FGF1 GTF2F2 FGF2 FGFR2 FGF3 FGF4 FGF6 NRAS FGF7 FGF9 FGF20 FGF23 PIK3R1 FGF22 FRS2 FGF16 FGF18 FGF10 DEFECTIVE SLC24A1 CAUSES CONGENITAL STATIONARY NIGHT BLINDNESS 1D (CSNB1D)%REACTOME DATABASE ID RELEASE 76%5619077 Defective SLC24A1 causes congenital stationary night blindness 1D (CSNB1D) SLC24A1 NOTCH4 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-9013695.1 NOTCH4 Intracellular Domain Regulates Transcription CREBBP HES1 FLT4 EP300 SMAD3 SNW1 HEY1 HEY2 MAML2 ACTA2 MAMLD1 MAML1 RBPJ KAT2B NOTCH2 KAT2A NOTCH4 MAML3 NOTCH1 HES5 RHOD GTPASE CYCLE%REACTOME%R-HSA-9013405.1 RHOD GTPase cycle TOR1AIP1 AKAP12 ACTN1 ANKFY1 DIAPH1 ARHGAP1 ARHGAP39 ARHGAP5 STEAP3 ARHGAP35 STBD1 VAPB LBR EMD TMPO RAB7A PAK5 VRK2 LEMD3 PIK3R1 ARHGAP12 MOSPD2 VAMP3 PAK6 FILIP1 ARHGAP17 PIK3R2 LMAN1 ARHGAP21 PGRMC2 RACGAP1 VANGL1 DEPDC1B GOLGA8R ADD3 CAV1 MCAM ARHGAP26 SLC4A7 ARHGAP32 EFHD2 DIAPH3 ESYT1 DBN1 WHAMM LMNB1 CPNE8 CAPZB HINT2 RHOD NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY%REACTOME%R-HSA-168333.3 NEP NS2 Interacts with the Cellular Export Machinery NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 RAN NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 XPO1 NUP155 NUP214 NUP153 PA PB2 NP NS M PB1 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 TRANSCRIPTIONAL REGULATION OF PLURIPOTENT STEM CELLS%REACTOME%R-HSA-452723.2 Transcriptional regulation of pluripotent stem cells PRDM14 HIF3A ZSCAN10 SMAD4 SOX2 FGF2 NR5A1 TDGF1 SALL1 EPAS1 SALL4 FOXD3 EPHA1 ZIC3 DPPA4 PBX1 STAT3 LIN28A NANOG KLF4 POU5F1 SMAD2 BETA-OXIDATION OF PRISTANOYL-COA%REACTOME DATABASE ID RELEASE 76%389887 Beta-oxidation of pristanoyl-CoA ACOT8 ACOXL AMACR ACOX2 CRAT HSD17B4 CROT ACOX3 METABOLISM OF STEROID HORMONES%REACTOME DATABASE ID RELEASE 76%196071 Metabolism of steroid hormones CYP17A1 CGA HSD17B14 CYP19A1 POMC AKR1B1 CYP11A1 HSD17B11 HSD17B1 HSD17B2 TSPO STARD3 STARD4 SRD5A2 STARD3NL STARD6 SRD5A1 STAR AKR1B15 CYP11B2 CYP21A2 TSPOAP1 HSD11B1 CYP11B1 HSD11B2 SERPINA6 FDXR HSD17B3 HSD17B12 LHB SRD5A3 FDX1 FDX2 HSD3B2 HSD3B1 RHO GTPASES REGULATE CFTR TRAFFICKING%REACTOME DATABASE ID RELEASE 76%5627083 RHO GTPases regulate CFTR trafficking CFTR RHOQ GOPC DOWNSTREAM TCR SIGNALING%REACTOME%R-HSA-202424.4 Downstream TCR signaling UBE2V1 TRAC CD3E TRBC1 CDC34 TRBV12-3 TRAV29DV5 TRBV7-9 TRAV19 BCL10 TRAV8-4 CD4 PDPK1 PIK3R1 BTRC NFKB1 SKP1 PIK3R2 FBXW11 TRAT1 UBA52 CUL1 UBB UBC RPS27A CARD11 MALT1 PRKCQ PIK3CA LCK UBE2D2 CD3G CD3D UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PTEN PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 INPP5D HLA-DQA2 PSMB6 HLA-DQA1 PSMB7 PSMB4 HLA-DRB5 PSMB5 HLA-DRB4 PSMB2 IKBKB PSMB3 HLA-DRB3 PSMB1 PSMF1 HLA-DRB1 CHUK NFKBIA PSMB8 PIK3CB RELA PSMB9 SEM1 IKBKG PSMC5 PSMC6 HLA-DPA1 PSMC3 HLA-DQB2 PSMC4 HLA-DQB1 PSMC1 PSMC2 HLA-DPB1 HLA-DRA RIPK2 TRAF6 UBE2N MAP3K7 TAB2 SIGNALING BY LRP5 MUTANTS%REACTOME DATABASE ID RELEASE 76%5339717 Signaling by LRP5 mutants LRP5 DKK1 DKK2 DKK4 KREMEN1 KREMEN2 LXR-MEDIATED SIGNALING%REACTOME%R-HSA-9024446.2 LXR-mediated signaling HDAC3 APOD ARL4C ABCG8 NR1H2 EEPD1 ABCG5 UGT1A3 ANGPTL3 RXRA ABCG1 CETP RXRB NRIP1 SCD AGO3 AGO4 AGO1 APOE AGO2 ABCA1 APOC4 NR1H3 KDM1A NCOA1 APOC2 APOC1 KDM4A GPS2 EP300 TBL1XR1 NCOR2 TNRC6C TBL1X MOV10 NCOR1 TNRC6A TNRC6B KDM1B PCK1 FASN FABP6 MYLIP PLIN1 KDM3A MPS IX - NATOWICZ SYNDROME%REACTOME%R-HSA-2206280.2 MPS IX - Natowicz syndrome HYAL1 REGULATION OF IFNA SIGNALING%REACTOME%R-HSA-912694.1 Regulation of IFNA signaling USP18 IFNA2 IFNA21 IFNA8 IFNA13 IFNA14 IFNA16 IFNB1 PTPN11 IFNA17 TYK2 SOCS3 PTPN1 IFNA10 IFNA5 SOCS1 PTPN6 IFNA4 IFNA7 IFNAR1 JAK1 IFNA6 STAT2 OAS ANTIVIRAL RESPONSE%REACTOME%R-HSA-8983711.2 OAS antiviral response OAS1 OAS2 OAS3 DDX58 ABCE1 PDE12 FLNA OASL RNASEL DRUG RESISTANCE OF FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702506 Drug resistance of FLT3 mutants FLT3 ADRENOCEPTORS%REACTOME DATABASE ID RELEASE 76%390696 Adrenoceptors ADRA2C ADRA2B ADRA2A ADRA1D ADRB1 ADRB2 ADRB3 ADRA1B ADRA1A PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622323.3 Presynaptic nicotinic acetylcholine receptors CHRNA6 CHRNG CHRNE CHRNB4 CHRNB2 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRND CHRNA5 CHRNA4 REGULATION OF INNATE IMMUNE RESPONSES TO CYTOSOLIC DNA%REACTOME%R-HSA-3134975.2 Regulation of innate immune responses to cytosolic DNA UBB TRIM32 UBC RPS27A DDX41 TRIM21 TBK1 TRIM56 UBA52 TREX1 IRF3 STING1 ZBP1 NLRP4 DTX4 HYDROLYSIS OF LPE%REACTOME%R-HSA-1483152.3 Hydrolysis of LPE PLA2G4C GPCPD1 TANDUTINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702636.1 tandutinib-resistant FLT3 mutants FLT3 PRPP BIOSYNTHESIS%REACTOME%R-HSA-73843.2 PRPP biosynthesis PRPS2 PRPS1 PRPS1L1 VIRAL MRNA TRANSLATION%REACTOME%R-HSA-192823.4 Viral mRNA Translation RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 PA PB2 NP NA NS HA M PB1 DNAJC3 GRSF1 CLEARANCE OF DOPAMINE%REACTOME DATABASE ID RELEASE 76%379401 Clearance of dopamine LRTOMT MAOA COMT SLC6A3 RESOLUTION OF D-LOOP STRUCTURES THROUGH SYNTHESIS-DEPENDENT STRAND ANNEALING (SDSA)%REACTOME DATABASE ID RELEASE 76%5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) BLM BRIP1 ATM BARD1 BRCA1 EXO1 RTEL1 RMI2 RMI1 BRCA2 TOP3A RAD51AP1 XRCC2 WRN XRCC3 PALB2 RBBP8 RAD51D MRE11 RAD51 KAT5 NBN RAD50 RAD51B RAD51C DNA2 INTERLEUKIN-17 SIGNALING%REACTOME DATABASE ID RELEASE 76%448424 Interleukin-17 signaling TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB IL25 IL17RE IL17RC IL17RB IL17RA IL17F IL17C IL17A PPP2R1A BTRC NFKB1 SKP1 MAPK8 FBXW11 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 CHUK MAPKAPK2 UBC JUN TNIP2 RPS27A IKBKG MAPK9 MAPK10 CREB1 NOD1 NOD2 MAPK14 MAPK11 IRAK1 IRAK2 ATF2 RIPK2 TRAF6 UBE2N TAB3 MAP3K7 TAB2 REGULATION OF GLYCOLYSIS BY FRUCTOSE 2,6-BISPHOSPHATE METABOLISM%REACTOME%R-HSA-9634600.1 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism PPP2CA PPP2R1A PPP2R5D PPP2CB PPP2R1B PFKFB2 PFKFB1 PRKACA PFKFB4 PFKFB3 PRKACG PRKACB RUNX1 INTERACTS WITH CO-FACTORS WHOSE PRECISE EFFECT ON RUNX1 TARGETS IS NOT KNOWN%REACTOME%R-HSA-8939243.1 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known YAF2 CBFB CBX8 CBX6 RUNX1 CBX4 CBX2 PHC2 PHC1 ACTL6B BMI1 RING1 PBRM1 CSNK2A1 ARID1A CSNK2A2 ARID1B PHC3 SMARCD1 SMARCD2 CSNK2B SMARCB1 ARID2 SMARCE1 AUTS2 SMARCC1 SMARCC2 SMARCD3 EP300 HIPK2 RNF2 ACTL6A PCGF5 SMARCA2 RYBP SMARCA4 GENE EXPRESSION (TRANSCRIPTION)%REACTOME DATABASE ID RELEASE 76%74160 Gene expression (Transcription) CREBBP CSF2 CBFB PRKCB RUNX1 IHH MAPK1 BGLAP MAPK3 MYL9 ITGA2B NCBP1 NCBP2 PLXNA4 ITGA5 MET CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 GRIN2B H2AX EHMT2 H2AB1 H2AC19 CHD4 CHD3 TTF1 ACTB H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 BAZ1B H2BC17 H2BC12 H2BC13 KAT2B H2BC14 CHEK1 H2AJ KAT2A H2BC15 POLR1A NUP107 POLR1B NUP188 POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 DDX21 TAF1D MTERF1 H3C15 MTA1 NUP210 TAF1B RBBP4 TAF1C NUP93 TAF1A H2BS1 POM121 RBBP7 MTA2 NUP205 LDB1 SF3B1 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 AAAS H4C9 H2BC8 H2BC5 NUP160 POM121C CBX3 H2BC3 NUP85 SMARCA5 TPR H2BC1 NUP88 DEK GATAD2B NUP155 GATAD2A MYBBP1A NUP153 H2AC20 ERCC6 CASP10 BCDIN3D XPO5 DROSHA NUP62 NDC1 HNF4G NUP133 NUP50 NUP54 HDAC3 NUP42 NUP43 RAE1 RANBP2 GCK NUP35 CSNK2A1 NUP37 CSNK2A2 CSNK2B TDG NFKB1 MEN1 FKBP5 NOTCH2 NOTCH3 NOTCH4 TNFRSF10B TNFRSF10A YES1 TNFRSF10D VEGFA DAXX BLK ELF1 ELF2 PAX5 GPAM CAVIN1 TSNAX AGO3 PRKRA AGO4 AGO1 AGO2 DICER1 TSN TARBP2 SKP2 FZR1 FASLG FAS SOCS3 PTPN1 PRKAA1 FOXO1 RPTOR STK11 AKT2 MLST8 SLC38A9 TSC2 TSC1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB OCLN RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 IRAK1 COL1A1 NOP2 HSPD1 PABPN1 CPSF4 TFAP2A TFAP2B TFAP2C PIWIL2 CGB8 TDRKH ATAD2 YY1 PIWIL1 PIWIL4 KIT PLD6 MEF2C HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 TDRD12 FKBP6 STAT1 LBR PPARD CEBPB SPI1 TAL1 DDIT3 KMT2A CDC25C HDAC6 TPX2 MYBL2 JAG1 CAV1 SNRPD3 SLBP PML CSTF3 CSTF1 SYMPK RB1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CCND1 CDK4 E2F1 PCF11 MAML2 MAML1 RBPJ WDR33 ITGAL MYC CCN2 TEAD1 TEAD2 TEAD3 TEAD4 BRD2 SRRT ITGA4 RUNX3 ATF2 MAML3 YAP1 NOTCH1 NUDT21 SRC TCF7 SERPINE1 LEF1 FOXO3 BCL2L11 HES1 SIRT1 WWTR1 TCF7L2 SMAD4 PAPOLA TCF7L1 ZFHX3 SMAD3 SMURF2 SNW1 CTNNB1 KRAS MAMLD1 GTF2A1 GTF2A2 GTF2B SNRPG PPARGC1A TAF9 TAF1L NR1D1 SNRPE GTF2E1 SNRPF GTF2E2 TAF7L TAF9B TAF15 TAF12 TAF13 SNRPB TAF10 TAF11 TAF7 TAF4B CPSF3 TAF6 CPSF2 TAF5 USP2 TAF4 TAF3 TAF2 TAF1 UBE2D3 PIN1 CSTF2T CASP2 FIP1L1 GP1BA MED1 SREBF1 SMARCD3 TBL1XR1 FOXO6 CARM1 NR4A1 TBL1X MRE11 TP53RK EHMT1 PRDM1 NOC2L KAT5 PIP4K2A PIP4K2B NBN KMT5A PIP4K2C TP63 HUS1 KAT6A MAPKAPK5 DNA2 RHNO1 L3MBTL1 BLM MEAF6 PPP2R1B MAPKAP1 BRIP1 NUAK1 SMYD2 TP53BP2 ATRIP BANP MAP2K6 TRPC3 BARD1 PLK3 BRPF1 BRPF3 JMY RAD17 PPP2R5C RAD9B TP73 ATR RAD9A PRR5 DYRK2 PPP1R13B SETD9 BRCA1 ING5 ING2 PIP4P1 EXO1 PPP1R13L PPP2CA TOPBP1 RFC5 PPP2CB PRMT5 RMI2 BRD1 RFC3 RFC4 RFC2 RMI1 PDPK1 TOP3A SGK1 RNF34 WRN PTPN11 TP53INP1 RBBP8 RICTOR RFFL BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 RAD50 TTC5 CALM1 RPA3 CCNG1 RAD1 CDK5R1 GLS GAMT ARID4B RRP8 SAP130 SAP30BP SAP30 DNMT1 BAZ2A SUDS3 PHF19 EZH2 SUV39H1 PHF1 DNMT3L SIN3B DNMT3B JARID2 EED TET2 TET1 AEBP2 MTF2 TET3 UHRF1 SAP30L SAP18 SUZ12 MBD2 JUN SOD2 PRDX2 PRDX1 RAD51D RAD51 MDC1 CCNK MT-CO1 TP53AIP1 COX7A2L SCO1 SCO2 DDIT4 MT-CO2 MT-CO3 TXN PRELID3A PRELID1 SURF1 CRADD GADD45A PLK2 CDK12 CDK13 GPI BTG2 COX7B COX7C BBC3 AIFM2 TNKS1BP1 COX8A CNOT6L PRMT1 FOS DDB2 PCNA COX5B COX5A PLAGL1 BDNF PERP PMS2 BID TIGAR NPM1 MLH1 COX6C LRPPRC STEAP3 CCNT2 TACO1 COX6A1 SESN3 SESN2 BNIP3L G6PD IGFBP3 COX6B1 MSH2 FANCD2 COX19 COX16 COX18 NDRG1 PMAIP1 COX11 BRF2 COX14 IPO8 BCL2L14 GTF3A ZNF420 FANCI TNFRSF10C CNOT10 FANCC CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 CNOT2 CNOT3 CYCS CNOT8 CNOT9 COX20 COX4I1 PTEN TRIAP1 PIDD1 CASP6 CASP1 APAF1 RABGGTB RABGGTA RBL2 RBL1 RRM2B TMEM219 BIRC5 NLRC4 E2F4 E2F7 E2F8 NDUFA4 ARID3A BAX NPPA TBX5 NKX2-5 HDAC10 HDAC11 TXNIP CCNC GLS2 HEY1 HEY2 TXNRD1 HSP90AA1 ERBB2 MYB YWHAE ESR2 CDK8 PPP2R1A ZFPM1 PRKACA HDAC5 GATA4 GATA3 YWHAG HDAC8 HDAC9 GATA2 SKP1 DLL1 GATA1 HDAC7 ABL1 NFE2 CBX5 CDK5 UBA52 CUL1 AURKA IL6 CCNB1 UBB UBC RPS27A SIN3A CENPJ CRH CDK1 CR1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR4A2 NR5A1 AR RXRA SUMO1 RARA PPARG PGR PPARA CCNH RNMT POLR2A POLR2B POLR2C POLR2D GRIA2 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J GRIN2A POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 STUB1 ANAPC15 ANAPC16 BTG1 ANAPC7 MSTN UBE2C CITED2 UBE2E1 IGFBP1 UBE2D1 TRIM63 SIRT3 ANAPC10 CAT ANAPC11 CDC23 RETN PCK1 UBE2S CDC26 KLF4 FBXO32 CDC16 G6PC1 CDC27 ANAPC4 PINK1 ANAPC5 CCNG2 AGRP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 APOE PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 PSMC2 TCEA1 AFF4 CDC73 CTR9 SMAD2 CLP1 WDR61 TNFRSF18 MLLT1 RTF1 MLLT3 SUPT6H IWS1 LEO1 CSTF2 EAF1 EAF2 PAF1 CPSF1 RAN GPX2 LSM10 LSM11 ZNF287 ZNF17 ZNF18 ZNF19 ZNF285 RBFOX1 ZNF282 NEDD4L ZNF10 ZNF12 ZNF14 CLDN5 ZNF28 ZNF274 ZNF273 ZNF20 ZNF23 ZNF25 ZNF26 ZNF268 ZNF267 ABCA6 PPARGC1B ZNF266 ZNF264 ZNF263 NR2F1 ZNF34 NR0B2 NR2F6 ZNF30 ZNF257 ZNF256 ZNF254 GTF3C1 ZNF496 GTF3C2 ZNF253 GTF3C3 ZNF493 GTF3C4 ZNF250 GTF3C5 ZNF492 GTF3C6 UCMA BRF1 ZNF490 BDP1 ZNF43 ZNF45 MED16 MED15 MED17 MED12 MED14 MED13 MED10 ZNF41 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ACTL6B RING1 WWP1 ZNF480 CGA MED27 MED26 MED23 MED25 MED24 MED20 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 SERPINB13 ZNF471 DDX4 ZNF470 ZNF227 ZNF226 ZNF468 ZNF225 ZNF224 ZNF223 ZNF222 ZNF221 ZNF461 ZNF460 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF697 ZNF213 ZNF696 ZNF454 ZNF212 RRN3 ZNF211 UBTF ZNF692 ZNF691 RORC RORB ZNF208 ZNF689 ZNF205 ZNF688 ZNF446 PITX2 AKT3 ZNF445 ZNF202 ZNF443 ZNF684 ZNF442 ZNF200 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ZFP69B FOXP3 MAF ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF675 ZNF433 PVALB ZNF432 ZNF431 KMT2E ZNF430 SFN ZNF671 KMT2D ZNF670 DLX5 DLX6 KMT2C KMT2B ZNF840P MED30 MOBP ZKSCAN7 ZNF429 MED31 ZKSCAN8 ZNF669 NPY ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 SOCS4 ZKSCAN1 CHM ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 SP7 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 HAND2 ZNF875 PPM1D ZNF627 PF4 ZNF626 ZNF625 ZNF624 ZNF621 E2F6 ZNF620 ZNF860 MGA ZNF619 IL2RA ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 PTPN4 ZNF610 EGFR TRIM33 SMARCB1 UXT ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 ZNF721 ZNF720 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B L3MBTL2 ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 ZNF700 HIVEP3 INTS1 INTS3 INTS2 SMARCA2 SMARCA4 INTS5 ITGBL1 INTS4 INTS7 INTS6 INTS9 INTS8 INTS11 INTS12 INTS13 INTS14 INTS10 BMI1 HNF4A PBRM1 SATB2 RXRB ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 ZFP28 PRDM7 ICE1 ICE2 ARID2 MSX2 SSU72 ZNF99 GPRIN1 TFAP2D TFAP2E AUTS2 IL2 IL3 BMP2 NABP2 NABP1 TCF3 DPY30 TGIF1 RBM14 ZNF75CP TGIF2 RNF2 OPRM1 RRM2 ZNF804B TAF8 ZNF175 PHAX ZSCAN32 ZNF169 NFIX SSB JUNB SLC2A3 ZNF705F NFIA ZNF705G NFIB ZNF705D NFIC ZNF705E ZNF160 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NR2C2AP ZNF143 PHC2 PHC1 ZNF383 ZNF141 ZNF382 ZNF140 SETD1B SETD1A OPRK1 NFATC2 NR1D2 CDC7 ELL2 PHC3 ELL3 ZNF37A ZNF702P POMC ZNF138 SST ZNF136 ZNF135 ZNF133 RARG ASH2L RSPO3 ZNF124 ZIK1 TCF12 RARB ZNF599 ZNF114 ZNF597 ZNF112 ZNF596 ZNF595 RNF111 ZNF350 ZNF347 ZNF589 PARP1 ZNF587 ZNF586 ZIM2 ZNF343 ACTL6A ZIM3 ZNF101 ZNF100 ZNF584 WWOX ZNF583 PCGF6 CDKN2B ZNF582 PCGF5 PCGF2 ZNF33B ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 YEATS4 ZFP30 TGFA ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZFP37 ZNF565 ZNF564 EIF4A3 ZNF563 CASC3 ZNF562 ZNF320 ZNF561 MAGOH ZNF560 THOC1 THOC3 NRBP1 THOC2 ZNF559 THOC5 ZNF317 CDC40 ZNF558 CTSL THOC7 ZNF557 THOC6 ZNF799 DDX39A CTSK ZNF556 DDX39B ZNF555 ZC3H11A ZNF554 SARNP ZNF311 SRSF2 ZNF552 SRSF3 ZNF551 SRSF4 ZNF793 SRSF5 ZNF550 SRSF6 CSF1R SRSF7 ZNF792 SLU7 ZNF791 SRSF9 ZNF790 KRBA1 FYTTD1 KRBOX4 LUZP4 RBM8A ZNF767P ZNF549 POLDIP3 SRSF1 ZNF548 U2AF1 ZNF547 ZNF546 U2AF1L4 ZNF304 U2AF2 SEC13 ZNF544 MMP13 DHX38 ZNF302 SRSF11 ZNF786 ZNF543 CHTOP ZNF785 ALYREF UPF3B SKIL MAGOHB ZNF300 ZNF782 ESRRA RNPS1 ZNF540 ZNF658B IFNG ESRRB ESRRG ZFP69 ZNF778 ZNF777 SPP1 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 CRCP ZC3H8 ZNF529 ZNF528 WDR5 ZNF764 TJP1 ZNF521 ZNF761 ZNF75D ZNF75A TFAM TFB2M ZFP90 POLRMT ZNF519 ZNF517 ZNF514 POLR3GL ZNF510 ZNF750 SMARCD1 SMARCD2 POLR3A ZNF749 RBBP5 POLR3B ZNF506 POLR3C ZNF747 POLR3D ZNF746 POLR3E ZNF500 POLR3F ZNF740 POLR3G SMARCE1 POLR3H RPRD2 POLR3K ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 SOX2 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 TWIST2 TWIST1 RPAP2 ZNF726P1 CITED1 CITED4 VENTX PRMT6 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B LMO1 LMO2 KCTD1 ATP1B4 LIFR KCTD6 RPRD1B RPRD1A CBX8 CBX6 POU2F1 CBX4 CBX2 SMAD6 POU2F2 NR4A3 KDM5B THRA NR2E1 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 ARID1A ARID1B ZNF197 ZNF195 NR2C2 THBS1 YWHAQ ZNF286A ZNF189 ZNF184 YWHAH ZNF180 ANG PRKAB2 PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 INS FOXO4 ATXN3 USP9X SMAD1 SMAD7 GSK3B AXIN1 YWHAB AKT1 NUP214 YWHAZ CAMK2B CAMK2D FOXG1 CAMK2A GPS2 HTT AURKB CAMK2G HIPK2 NCOR2 TNRC6C MOV10 CREB1 NCOR1 CAMK4 TNRC6A TNRC6B MAPK14 MAPK11 PRKCQ CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 CCNA1 CCNE2 CCNE1 TP53 PCBP4 NFYA CDKN2A CDK2 MDM2 NFYB ATM NFYC MDM4 RBX1 SP1 MAX E2F5 GLI3 GLI2 ITCH CPSF7 SRRM1 RELA ELAC2 TGFB1 SMURF1 LGALS3 BINDING AND UPTAKE OF LIGANDS BY SCAVENGER RECEPTORS%REACTOME DATABASE ID RELEASE 76%2173782 Binding and Uptake of Ligands by Scavenger Receptors V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 HSP90AA1 IGLV3-25 IGLV3-27 APOB IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 HP IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 CD163 CALR IGLV7-43 HPR IGKV1D-16 HPX IGKV1D-12 IGHA1 IGHA2 IGLV1-51 AMBP IGLV2-23 IGKV3-20 JCHAIN IGHV4-34 HBB IGHV1-2 FTH1 HSPH1 IGHV4-39 IGKV2-29 MASP1 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 COLEC11 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 porB CD36 LRP1 HYOU1 SCARF1 SCARA5 MSR1 SSC5D MARCO SCGB3A2 STAB1 COLEC12 APOA1 SAA1 HSP90B1 APOE IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 ALB IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 SPARC V1-11 FTL IGKV2D-30 HBA2 APOL1 V1-16 V1-13 COL1A1 IGHV1-69 COL3A1 COL1A2 STAB2 COL4A2 COL4A1 CELL SURFACE INTERACTIONS AT THE VASCULAR WALL%REACTOME%R-HSA-202733.5 Cell surface interactions at the vascular wall V1-20 JAM2 SLC3A2 JAM3 IGKV2D-40 FN1 IGHV3-11 IGHV3-13 IGHV1-46 IGHV ITGB1 V5-4 V5-1 ATP1B3 ATP1B2 ATP1B1 FYN V5-6 IGLV3-19 ITGA3 GAS6 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV OLR1 V3-4 V3-3 PIK3R2 V3-2 IGKV1D-39 IGKV1D-33 L1CAM IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CAV1 IGLV1-44 IGKV3-15 SELP IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGHA1 IGHA2 IGLV1-51 IGLV2-23 JCHAIN IGKV3-20 IGHV4-34 IGHV1-2 ITGAM IGHV4-39 ITGB2 IGKV2-29 IGKV2-28 BSG IGLC3 ITGAX IGLC1 IGLC2 V1-9 ITGB3 V1-7 V1-5 ITGAL V1-3 ITGAV IGKV3D-20 ITGA5 IGKV2-30 ITGA4 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 MIF IGKV5-2 IGLC6 LCK GRB7 FCER1G CEACAM3 MAG CEACAM1 MMP1 CEACAM6 CEACAM8 CD47 CD58 DOK2 CD44 PROS1 SIRPA THBD PF4V1 CD177 PPIA SELL PROCR PROC INPP5D PIK3CB SLC7A7 SLC7A9 SLC16A1 CEACAM5 PECAM1 TSPAN7 APOB PICK1 PTPN11 PIK3R1 GP6 PTPN6 SLC7A6 SLC7A8 TREM1 SLC16A8 LYN TNFRSF10B YES1 TNFRSF10A SLC16A3 TNFRSF10D SDC4 SDC2 SDC3 GPC1 F2 SHC1 PIK3CA PLCG1 SOS1 SDC1 SLC7A5 VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 FCAMR PSG9 PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB PF4 CD99L2 GLG1 piiC PF3D7_1301600 CD48 SELPLG EPCAM CD74 ebl-1 IGLL1 CD84 SIRPG GRB14 JAML PSG11 CD99 SELE IGHM ESAM opaD opaE opaF opaG opaA opaB IGHV3-23 opaC opaH IGLV2-8 opaI opaJ IGKV1-16 opaK HRAS ANGPT4 IGKV1-17 ANGPT2 IGKV1-12 MERTK IGHV3-7 CD2 IGHV3-9 SPN SLC7A11 PPIL2 IGHV3-30 SLC7A10 V2-17 IGHV3-33 NRAS V2-15 V2-19 IGKV2D-28 IGKV4-1 ITGA6 IGHV7-81 TGFB1 V1-11 IGKV2D-30 ANGPT1 F11R V1-16 TEK V1-13 IGHV1-69 INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION%REACTOME DATABASE ID RELEASE 76%168273 Influenza Viral RNA Transcription and Replication NUP42 NUP43 RAE1 RANBP2 NUP35 NUP37 HSP90AA1 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 IPO5 RPL21 NUP214 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 PARP1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L PA PB2 GTF2F1 NP NA NS GTF2F2 HA M PB1 SEC13 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 DNAJC3 NUP62 NDC1 NUP133 GRSF1 NUP50 NUP54 TNFR2 NON-CANONICAL NF-KB PATHWAY%REACTOME DATABASE ID RELEASE 76%5668541 TNFR2 non-canonical NF-kB pathway TNFRSF9 TNFSF13 TNFRSF1B TNFRSF1A EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 TNFSF8 TRAF2 BTRC SKP1 FBXW11 RELB UBA3 MAP3K14 UBE2M UBA52 TNFRSF12A TNFSF12 TNFRSF11A TNFRSF13C CUL1 CD40LG LTBR LTB UBB UBC RPS27A TNF TRAF3 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 BIRC2 PSMD10 BIRC3 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 CHUK PSMB8 PSMB9 SEM1 NFKB2 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TNFRSF6B EDA TNFRSF13B TNFRSF11B EDA2R TNFSF13B TNFSF11 TNFRSF17 TNFRSF8 TNFRSF14 TNFRSF4 TNFSF18 EDARADD TNFSF14 TNFSF15 CD70 TNFRSF18 MOLECULES ASSOCIATED WITH ELASTIC FIBRES%REACTOME DATABASE ID RELEASE 76%2129379 Molecules associated with elastic fibres BMP7 GDF5 MFAP5 MFAP4 MFAP1 MFAP3 MFAP2 ITGA8 ITGB1 LTBP1 BMP4 BMP2 ITGB3 VTN ITGAV BMP10 TGFB1 LTBP4 LTBP2 FBLN1 LTBP3 FBLN2 FBLN5 EFEMP2 EFEMP1 ITGB8 ITGB6 ITGB5 TGFB2 TGFB3 NONSENSE MEDIATED DECAY (NMD) ENHANCED BY THE EXON JUNCTION COMPLEX (EJC)%REACTOME DATABASE ID RELEASE 76%975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) PPP2CA PPP2R1A RPL4 RPL5 RPL30 RPL3 RPL32 PPP2R2A RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 UPF3A RPS4X RPS15 RPL7A RPS14 RPS17 UPF2 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 UPF1 RPS9 RPS7 RPL21 NCBP1 RPS8 SMG1 SMG9 NCBP2 RPS5 SMG7 RPL23 SMG8 RPL22 SMG5 RPS6 SMG6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 DCP1A GSPT1 EIF4G1 RPS15A PNRC2 RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU EIF4A3 RPS21 CASC3 RPL26L1 RPS24 MAGOH RPS23 RBM8A UPF3B MAGOHB RNPS1 CARBOHYDRATE METABOLISM%REACTOME%R-HSA-71387.9 Carbohydrate metabolism HAS2 CHP1 FBP1 SLC25A11 FBP2 PCK2 SLC37A1 MDH1 MDH2 G6PC2 ENO1 PGK1 B4GAT1 PPP2R1A G6PC3 PYGB PRKACA PYGL TKFC PGAM1 ABCC5 KHK HMMR AGL GALK1 UBA52 GALT GALE UBB UBC GBE1 RPS27A PGM1 RHCE RHD GLYCTK HSPG2 BCAN PFKL ARSB ALDOB MANBA GAA ALDOC ALDOA DCN SEC13 EPM2A PRPS2 PRPS1 CD44 RPEL1 RPE TALDO1 PCK1 PGD NUP107 DERA NUP188 G6PC1 ADPGK RPIA ENO2 SHPK ENO3 PGM2 PPP1R3C HK2 PGLS ACAN TPI1 TKT PGAM2 PRPS1L1 BPGM RBKS PGM2L1 NAGLU PGP GAPDH PFKFB2 PFKFB1 NUP210 PFKFB4 PFKFB3 PGK2 NUP93 GNPDA1 GNPDA2 PFKM POM121 PFKP NUP205 NHLRC1 HPSE2 XYLT2 XYLT1 AAAS MAN2B1 SGSH IDS NUP160 POM121C GUSB NUP85 IDUA TPR B3GAT2 NUP88 B3GAT1 GLB1L GCKR NUP155 HPSE HK3 PC NUP153 SLC2A1 GYG2 HK1 SLC37A4 NUP62 NDC1 NUP133 GYS2 HYAL1 DSE HYAL3 NUP50 DSEL DCXR NUP54 UST PPP2R1B NUP42 NUP43 RAE1 RANBP2 GCK NUP35 PPP2R5D NUP37 GAPDHS PPP2CA PPP2CB ST3GAL4 ST3GAL1 AKR1A1 ST3GAL2 SLC35B3 SLC35B2 FUT10 FUT11 B3GALT4 B3GALT5 SLC35D2 CALM1 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 B4GALNT2 SLC9A1 NUP214 SLC25A1 SLC26A1 SLC26A2 B4GALT1 SDC4 SDC2 HEXB SDC3 HEXA ALDH1A1 PRELP PAPSS2 GPC1 GPC3 GPC2 GPC5 GPC4 HS3ST3A1 CHST14 UGP2 HS6ST1 GPC6 HS6ST2 ST3GAL3 GPI CHST6 HS2ST1 HS6ST3 B3GAT3 NDST2 LUM NDST1 OMD NDST4 KERA NDST3 B3GALT6 EXT1 HS3ST3B1 PRKACG GLCE EXT2 PRKACB OGN HS3ST5 SDC1 HS3ST6 FMOD HS3ST4 AGRN HS3ST1 GNS B4GALT7 HS3ST2 AKR1B1 PAPSS1 G6PD ST6GALNAC6 B4GALT2 B4GALT3 B3GNT7 B3GNT4 B3GNT3 CHST1 ST3GAL6 B3GNT2 B4GALT6 CHST5 B4GALT4 CHST2 B4GALT5 CSGALNACT1 CHST7 CHPF CHPF2 NCAN CSGALNACT2 BGN VCAN GLB1 CHSY1 CHST11 CHST12 CHST15 CSPG5 CSPG4 CHSY3 CHST13 CHST3 GOT1 GOT2 GYS1 GYG1 MAN2B2 MAN2C1 XYLB PHKA1 PHKA2 ABO PYGM FUT1 PHKB CRYL1 SORD LALBA PHKG1 SLC25A10 PHKG2 SLC25A12 SLC25A13 CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 TELOMERE C-STRAND SYNTHESIS INITIATION%REACTOME%R-HSA-174430.4 Telomere C-strand synthesis initiation PRIM2 PRIM1 ACD POLA1 TINF2 POLA2 TERF1 TERF2 CTC1 STN1 POT1 TERF2IP TEN1 NCAM1 INTERACTIONS%REACTOME%R-HSA-419037.1 NCAM1 interactions CACNA1I COL6A2 CACNA1S COL4A3 PRNP COL6A1 PSPN COL4A5 GDNF COL9A1 COL6A3 COL9A3 COL6A6 COL9A2 COL6A5 AGRN CACNB1 CACNB2 CACNB3 CACNB4 NCAM1 ARTN GFRA1 GFRA2 GFRA4 ST8SIA4 CNTN2 NRTN ST8SIA2 CACNA1D NCAN CACNA1C COL4A2 CACNA1H COL4A1 CACNA1G COL4A4 CS DS DEGRADATION%REACTOME DATABASE ID RELEASE 76%2024101 CS DS degradation CSPG5 CSPG4 DCN ARSB BCAN IDS IDUA HEXB HEXA HYAL1 NCAN HYAL3 BGN VCAN ACTIVATION OF RAC1%REACTOME%R-HSA-428540.4 Activation of RAC1 ROBO1 PAK2 SOS1 PAK5 PAK4 RAC1 SOS2 PAK3 PAK1 NCK2 PAK6 SLIT2 NCK1 GRB7 EVENTS IN ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 76%1306955 GRB7 events in ERBB2 signaling NRG1 NRG2 GRB7 ERBB2 ACETYLCHOLINE REGULATES INSULIN SECRETION%REACTOME DATABASE ID RELEASE 76%399997 Acetylcholine regulates insulin secretion GNA11 PLCB3 PRKCA PLCB1 PLCB2 MARCKS GNA14 GNAQ GNA15 CHRM3 RAB REGULATION OF TRAFFICKING%REACTOME%R-HSA-9007101.3 Rab regulation of trafficking RAB6B TBC1D15 TBC1D16 TRAPPC2 DENND4B TRAPPC3 DENND4A RAB4A DENND4C TRAPPC1 CCZ1 ANKRD27 TRAPPC4 TRAPPC5 HPS1 HPS4 TRAPPC8 TRAPPC9 TRAPPC6A TBC1D2 RABEP1 TBC1D3 RAB5A YWHAE ALS2 TRAPPC6B RAB7A TBC1D7 RAB8A RAB1A RAB1B DENND3 RAB21 RAB10 OPTN RAB14 RAB12 RAB13 RAB18 AKT1 RINL TBC1D10C TBC1D10A TBC1D10B RABGEF1 ULK1 RIN3 AKT3 RIN1 RIN2 GABARAPL2 SYTL1 GAPVD1 GABARAP RAB39A RAB27A RAB39B RAB27B MON1A CCZ1B MON1B RAB3IP GDI1 GDI2 MAP1LC3B DENND1C DENND1B RAB8B DENND1A RAB33A CHM RAB33B RAB7B DENND2D DENND2C RABGAP1 DENND2B DENND2A RAB3IL1 ALS2CL RAB11A RAB11B RGP1 RAB3GAP2 ARF6 RAB9A RAB9B AKT2 GGA2 RAB3GAP1 GGA1 GGA3 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 TSC2 CHML SBF1 TSC1 RIC1 SBF2 TRAPPC10 RAB3A TRAPPC2L TBC1D20 TBC1D24 RAB32 DENND6B DENND6A RAB31 RAB35 RAB38 RAB5B RAB5C TBC1D13 TBC1D14 RAB6A TBC1D17 OTHER SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 76%416700 Other semaphorin interactions SEMA4D PLXNA4 PTPRC PLXNB3 SEMA5A ITGB1 CD72 PLXND1 TREM2 PLXNC1 ITGA1 SEMA6A TYROBP SEMA6D SEMA3E SEMA7A PLXNA2 SEMA4A PLXNA1 DEFECTIVE F8 CLEAVAGE BY THROMBIN%REACTOME DATABASE ID RELEASE 76%9672391 Defective F8 cleavage by thrombin F2 F8 VWF ADAPTIVE IMMUNE SYSTEM%REACTOME%R-HSA-1280218.5 Adaptive Immune System PRKCB PPP3R1 NFATC1 FCGR1B RNF213 FYN PAK3 ITGB7 RAB7A SIGLEC9 SIGLEC5 UBR4 PTPRC ITGB2 PIK3CD TREM2 ITGAV EVL ELOB ELOC PTPRJ ACTR1B CTSH VASP CD33 SIAH1 LCP2 ENAH LILRA3 LAIR1 TYROBP HUWE1 LILRB2 LILRB3 CD300A OSCAR PPIA SELL IKBKB CHUK IKBKG BTNL9 BTNL8 BTN3A1 BTN2A2 BTN2A1 CD209 BTN1A1 BTN3A3 BTNL2 BTN3A2 PPL XDH UBE2B FBXO4 FBXO6 FBXW4 TAP2 FBXW5 TAP1 CD207 FBXW10 SEC61A2 FBXW7 MRC2 FBXW9 SEC61A1 SEC61G SEC61B FBXW2 TAPBP VAV1 LRRC41 RNF41 FBXL3 FBXL5 NFKB1 NFKBIB LYN YES1 CDC20 CSK BLK PIK3CA PLCG1 SOS1 SKP2 FZR1 CTSA ZAP70 MYD88 LY96 CD14 TLR4 SOCS3 DAPP1 RASGRP3 CD79B CD79A REL NFKBIE CD22 IGHM AKT2 BLNK IGHD MLST8 MTOR RIPK2 TRAF6 UBE2N ITGB5 TAB2 UBE2V1 ITGB1 NCF1 NCF2 SNAP23 NCF4 CYBB CYBA CD86 CD80 TRIB3 VAMP3 PIK3R2 RACGAP1 FBXL7 UBA3 MAP3K14 UBE2M FBXL18 ITGAL ITGA4 SMURF2 RBCK1 UBA7 UBE2D2 UBE2D3 UBE2L6 HERC5 UBE2K FGB FGA FGG INPP5D MAP3K8 PPP2R1B MAPKAP1 PPP2R5E TRAC CD3E PPP2R5B GRAP2 TRBC1 PPP2R5A ICOSLG PPP2R5D PDCD1LG2 PPP2R5C CD274 TRBV12-3 STIM1 TRAV29DV5 TRBV7-9 ORAI2 PRR5 BTLA ORAI1 TRAV19 TRAV8-4 ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PDPK1 RNF34 PTPN11 RICTOR LAT PTPN6 CALM1 DYNLL2 KLRK1 CUL2 VHL NCR2 KIR2DS2 ITK CD300LB TREM1 CD300E KLRD1 CD40LG PVR NECTIN2 COLEC12 CXADR PTEN CD74 JAML CD99 AHCYL1 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 FYB1 IGKV2D-30 TREML1 TREML4 V1-16 TREML2 V1-13 IGHV1-69 HCST HLA-DMA HLA-DMB KIR3DL1 KIR3DL2 SIGLEC1 PLCG2 SIGLEC8 CD19 ATG7 SIGLEC7 SIGLEC6 V1-20 HN HLA-DOA IGKV2D-40 IGHV3-11 HLA-DOB LAG3 IGHV3-13 PIANP RILP FCGR2B CD226 IGHV1-46 CD1D CD1C CD1B CD1A IGHV SLAMF7 SLAMF6 PAG1 V5-4 PILRB V5-1 PILRA SYK CD200 CTSO CTSF CTSE V5-6 NCR1 NCR3 MICA MICB IGLV3-19 NPDC1 MIB2 CD96 CD8A KIR2DL1 KIR2DL2 KIR2DL3 WAS KIR2DL4 CRTAM KIR2DS1 KIF5C CD200R1 IGLV3-25 KIF5B CLEC4G KIF5A IGLV3-27 CD300LD IGKC CD300LF IGLV3-21 CD300LG CD160 V4-6 PTPN22 KIFAP3 V4-2 CLEC2B V4-1 CLEC2D IGKV1-5 CD101 ACTR1A cd21 SIGLEC12 PPP2R1A SIGLEC11 KIF20A SIGLEC10 SH2D1A SH2D1B IGLV BTRC RAET1E PRKACA LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 KLC1 NCR3LG1 V3-4 SKP1 LAIR2 V3-3 GLYCAM1 V3-2 LILRB1 IGKV1D-39 KLC4 LILRB4 IGKV1D-33 KLC3 LILRB5 FBXW11 KLC2 KLRF1 TRAT1 KIF3B CD300C KLRB1 PIK3AP1 KLRC1 KIF3C ULBP1 ULBP3 KLRG1 IGHV4-59 DYNLL1 IGLV2-11 IGLV1-40 KIF18A IGLV1-47 IGLV6-57 IGLV2-14 KIF4B KIF4A UBA52 IGLV1-44 IGKV3-15 PDIA3 IGKV3-11 V2-8 DYNC1I2 DCTN2 CALR DCTN3 IGLV7-43 IGKV1D-16 CUL1 HLA-H IGKV1D-12 HLA-B HLA-C IGLV1-51 HLA-F IGLV2-23 HLA-G IGKV3-20 HLA-E UBB IGHV4-34 IGHV1-2 CD81 IGHV4-39 UBC FCGR3A KIF11 RPS27A KIF15 IGKV2-29 IGKV2-28 IGLC3 CAPZB IGLC1 IGLC2 V1-9 DYNC1H1 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 KIF23 KIF22 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 KIF2A IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 KIF2C IGLC7 KIF2B IGKV5-2 IGLC6 B2M HLA-A CD8B LCK CENPE CD28 KIF26A CAPZA1 CAPZA2 UL83 HA NEDD4 MKRN1 STUB1 CLTA ANAPC7 AP2A1 UBE2C UBE2E1 UBE2D1 TRIM63 AP2A2 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 FBXO32 CDC16 CDC27 AP2M1 ANAPC4 ANAPC5 MYLIP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 SAR1B PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 AP2S1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 AP2B1 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 RAP1GAP2 PSMC3 RASGRP2 PSMC4 RASGRP1 CUL5 PSMC1 RAP1GAP PSMC2 RAP1B RAP1A RAF1 SIPA1 RAPGEF3 RAPGEF4 TNFRSF14 UBE2Z UBE2L3 UBE2Q2 UBE2E3 CDC34 UBE2R2 UBA6 BCL10 UBE2J2 NEDD4L UBE2H UBE2G1 UBE2A UBE2G2 UBE2W UBA1 CANX C3 CTLA4 WWP1 AKT3 AP1S2 AP1S1 AP1S3 DYNC1LI1 DYNC1LI2 CUL7 TRPC1 LNPEP ARF1 LRR1 CCNF VAMP8 FBXO7 FBXO9 WSB1 FBXO2 FBXL8 FBXL4 GAN KLHL2 KLHL3 STX4 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 KLHL42 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 AP1M2 AP1M1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 KBTBD13 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 FBXL21P ASB15 ASB16 FBXL20 ASB10 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 AP1G1 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 SEC22B CBLB SEC23A DCAF1 HERC4 RNF115 HERC3 RNF114 HERC1 HERC6 RNF126 HECW2 CBLL2 TRIM11 ANAPC13 UBE2J1 RNF217 HACE1 SEC24B MEX3C SEC24A UBAC1 DZIP3 RNF220 NFATC2 DET1 LRSAM1 TRIM9 TRIM4 ARIH2 RNF144B RNF138 RNF130 RLIM SEC24D TRIP12 UBE2D4 SEC24C UBE3C UBE3D LTN1 RNF19B UBE3A UBE3B NPEPPS RNF19A AREL1 UBE2E2 UBE4A TRAIP UBA5 CDH1 RNF111 UBR2 UBR1 LONRF1 GLMN UBOX5 UBE2U RNF182 UBE2O TPP2 BLMH TRIM71 AP1B1 RNF14 UFL1 UBE2V2 UBE2Q1 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 MGRN1 RNF6 RNF4 RCHY1 ZNRF1 ZNRF2 HECTD1 HECTD2 HECTD3 TRIM41 ERAP2 RNF25 ERAP1 TRIM39 LNX1 TRIM36 TRIM37 SEC31A SPTBN2 CTSS CTSL CTSK SH3KBP1 CTSD CTSB CD3G CD3D CTSC SEC13 SOCS1 DYNC1I1 TRIM21 CAPZA3 ACTR10 TRIM32 SH3GL2 PIK3CB TLR1 THEM4 S100A9 S100A8 TLR2 KCTD6 KEAP1 RNF123 SIAH2 DNM1 CD4 DNM2 PRKN DNM3 CLTC PIK3R1 SH3RF1 DCTN6 CDC42 DCTN5 PAK1 DCTN1 DCTN4 NCK1 LGMN HERC2 YWHAB AKT1 YWHAZ ICAM2 ICAM3 CARD11 NFATC3 MALT1 PRKCQ PRKACG PRKACB RBX1 S100A1 HMGB1 TIRAP HSPA5 mip BTK porB KIF3A TLR6 CD36 ITCH OSBPL1A PDCD1 IFITM1 IFI30 ICAM1 CUL3 MRC1 RBBP6 HLA-DQA2 HLA-DQA1 HLA-DRB5 HLA-DRB4 HLA-DRB3 HLA-DRB1 HRAS NFKBIA RELA HLA-DPA1 NRAS HLA-DQB2 HLA-DQB1 KBTBD7 HLA-DPB1 ICAM4 PIK3R3 VCAM1 SMURF1 ICAM5 HLA-DRA PPP3CA FKBP1A PPP3CB MAP3K7 SYNTHESIS OF (16-20)-HYDROXYEICOSATETRAENOIC ACIDS (HETE)%REACTOME DATABASE ID RELEASE 76%2142816 Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) CYP2C9 CYP2C8 CYP4A11 CYP1A2 CYP1B1 CYP2C19 CYP4F2 CYP2U1 CYP1A1 TRANSCRIPTION FROM MITOCHONDRIAL PROMOTERS%REACTOME%R-HSA-75944.4 Transcription from mitochondrial promoters TFB2M POLRMT MTERF1 TFAM IMATINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9669917 Imatinib-resistant KIT mutants KIT DEFECTIVE SLC34A2 CAUSES PALM%REACTOME DATABASE ID RELEASE 76%5687583 Defective SLC34A2 causes PALM SLC34A2 MITOTIC ANAPHASE%REACTOME DATABASE ID RELEASE 76%68882 Mitotic Anaphase LBR EMD KPNB1 TUBA1A PPP2R1A LEMD3 PPP2R2A VPS4A DYNLL1 CKAP5 TUBA4A KIF18A MAPRE1 UBA52 IST1 PAFAH1B1 DYNC1I2 CENPF CCNB2 CCNB1 UBB UBC RPS27A CLASP1 DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A CDK1 ZW10 KIF2A UBE2I KIF2C KIF2B RPS27 SUMO1 CENPE ANAPC15 ANAPC16 SEC13 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DYNC1I1 BANF1 PSMD3 PSMD1 PSMA5 NUP93 PSMA6 PSMA3 POM121 PSMA4 NUP205 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 ITGB3BP PSMB11 PSMD12 PSMD11 NUP160 PSMD14 NUP85 PSMD13 PSMA7 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 PSMB4 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CHMP4C PSMC4 CHMP4B PSMC1 PSMC2 CHMP4A NUP62 NDC1 CDCA5 NUP133 PDS5B PDS5A WAPL NUP54 PPP2R1B PPP2R5E TUBB6 TUBB3 TUBB1 NUP43 VRK1 RANBP2 RAN PPP2R5B CDCA8 PPP2R5A NUP35 SKA1 PPP2R5D SKA2 CHMP2B PPP2R5C NUP37 ANKLE2 CHMP2A TUBA4B NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU CHMP3 TUBA8 CENPH CHMP6 TUBA1C CENPI CHMP7 TUBA1B TAOK1 CENPK CENPL CENPM TUBB2B TUBB2A CENPN DYNLL2 CENPO CENPP CENPQ CENPS TUBAL3 SMC3 TUBA3E TUBB8 SPAST TUBB8B LEMD2 CC2D1B TUBA3D TUBA3C CLIP1 RAD21 MAD1L1 STAG1 NDC80 STAG2 SMC1A SPDL1 XPO1 RANGAP1 TNPO1 NSL1 CDC20 LMNB1 ESPL1 PTTG1 AURKB PPP1CC KNL1 DSN1 RCC2 ZWINT AHCTF1 NDEL1 MIS12 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 SGO1 SGO2 PMF1 RCC1 BUB1B BUB3 MAD2L1 BUB1 SIRT2 BIRC5 P53-DEPENDENT G1 DNA DAMAGE RESPONSE%REACTOME%R-HSA-69563.3 p53-Dependent G1 DNA Damage Response CCNA1 CCNE2 CCNE1 TP53 COP1 PCBP4 CDKN2A CDK2 MDM2 ATM MDM4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 KINESINS%REACTOME DATABASE ID RELEASE 76%983189 Kinesins KLC2 KIFC1 KIF3B KIF2C RACGAP1 KIF3C KIF2B KIF18A KIF18B CENPE KIF4B KIF26A KIF4A KIF26B KIF3A KIF28P KIF12 KIF5C KIF5B KIF11 KIF5A KIF15 KIF21A KIF21B KIF19 KIFAP3 KIF13B KIF1C KIF1B KIF16B KIF20A KIF1A KIF20B KIF25 KIF23 KIF22 KIF6 KLC1 KIF27 KIF9 KLC4 KIF2A KLC3 KIFC2 SIGNALING BY EGFR%REACTOME%R-HSA-177929.2 Signaling by EGFR EPS15L1 EPS15 SHC1 PTPRK TGFA LRIG1 GAB1 PIK3CA SPRY1 PLCG1 SOS1 PXN EGF ADAM12 ARHGEF7 AAMP EPGN SPRY2 PAG1 UBA52 HBEGF EGFR STAM SH3GL3 EPN1 SH3KBP1 UBB CSK HRAS SH3GL2 UBC SH3GL1 HGS RPS27A PTPN12 NRAS PTPN11 STAM2 PIK3R1 ADAM10 AREG CDC42 ADAM17 EREG PTPN3 BTC CBL SRC DOWNSTREAM SIGNALING OF ACTIVATED FGFR4%REACTOME DATABASE ID RELEASE 76%5654716 Downstream signaling of activated FGFR4 KLB HRAS GAB1 FGF1 FGF2 PIK3CA PLCG1 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF19 FGF18 FGFR4 POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-622327.3 Postsynaptic nicotinic acetylcholine receptors CHRNA6 CHRNB4 CHRND CHRNA9 CHRNG CHRNE CHRNB2 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 ACTIVATED NTRK2 SIGNALS THROUGH FYN%REACTOME DATABASE ID RELEASE 76%9032500 Activated NTRK2 signals through FYN RAC1 BDNF GRIN2B DOCK3 SRC NTRK2 G2 M TRANSITION%REACTOME%R-HSA-69275.5 G2 M Transition PPP2R1B PPP2CA PPP2CB HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PPP1CB PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 PPP2R2A OFD1 PPME1 PPP1R12A PHLDA1 CEP135 HSP90AB1 GTSE1 BORA FKBPL FBXW11 CDC25C TUBB CEP131 CDC25B TUBGCP2 HAUS4 HMMR HAUS3 CSNK1D PKMYT1 TPX2 HAUS6 TUBGCP5 HAUS5 CSNK1E TUBGCP6 TUBGCP3 TUBG1 TUBGCP4 DYNLL1 FBXL7 CKAP5 LIN54 HAUS2 TUBA4A FOXM1 MYBL2 HAUS1 AKAP9 LIN52 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 UBA52 NME7 AJUBA LIN37 OPTN LIN9 SDCCAG8 LCMT1 PAFAH1B1 CDK11A DYNC1I2 FBXL18 DCTN2 PPP2R3B SSNA1 CDK11B XPO1 DCTN3 MZT1 CUL1 CENPF AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CDKN1A CEP43 CCNA2 CCNA1 TP53 CDK2 RBX1 WEE1 CCNH EP300 CDK7 MNAT1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PKMTS METHYLATE HISTONE LYSINES%REACTOME DATABASE ID RELEASE 76%3214841 PKMTs methylate histone lysines ATF7IP H3C15 SMYD2 RBBP4 PRDM16 WDR5 SETDB1 SETDB2 RBBP7 SUV39H2 SETD1B SETD2 SETD1A SETD3 SETD6 SETD7 EZH2 SUV39H1 H4C9 KMT2E RBBP5 ASH1L EED KMT2D DOT1L ASH2L NSD3 AEBP2 EHMT2 NSD1 KMT2C MECOM KMT2B NSD2 SUZ12 PRDM9 RELA DPY30 NFKB2 KMT5B H3C8 KMT5C EHMT1 SMYD3 KMT2A KMT5A NFKB1 IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL%REACTOME%R-HSA-198933.6 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell SIGLEC7 V1-20 SIGLEC6 HN IGKV2D-40 IGHV3-11 IGHV3-13 PIANP FCGR2B CD226 CD1D IGHV1-46 CD1C CD1B CD1A IGHV SLAMF7 SLAMF6 ITGB1 V5-4 PILRB V5-1 PILRA CD200 V5-6 NCR1 NCR3 ITGB7 MICA IGLV3-19 MICB NPDC1 CD96 CD8A KIR2DL1 KIR2DL2 KIR2DL3 KIR2DL4 CRTAM KIR2DS1 CD200R1 IGLV3-25 CLEC4G IGLV3-27 CD300LD IGKC CD300LF IGLV3-21 CD300LG CD160 V4-6 V4-2 CLEC2B V4-1 CLEC2D IGKV1-5 cd21 SIGLEC12 SIGLEC11 SIGLEC10 SH2D1A SH2D1B RAET1E IGLV SIGLEC9 LILRA6 LILRA1 LILRA2 LILRA4 LILRA5 NCR3LG1 LAIR2 V3-4 GLYCAM1 V3-3 LILRB1 V3-2 LILRB4 IGKV1D-39 LILRB5 IGKV1D-33 KLRF1 CD300C KLRB1 KLRC1 ULBP1 ULBP3 KLRG1 IGHV4-59 SIGLEC5 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 HLA-H IGKV1D-16 HLA-B IGKV1D-12 HLA-C HLA-F IGLV1-51 HLA-G IGLV2-23 HLA-E IGKV3-20 IGHV4-34 IGHV1-2 CD81 IGHV4-39 ITGB2 FCGR3A CDH1 IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 TREM2 ITGAL V1-3 IGKV3D-20 IGKV2-30 ITGA4 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 B2M HLA-A CD8B CD33 UL83 CD3G CD3D HA LILRA3 LAIR1 TYROBP LILRB2 LILRB3 CD300A OSCAR SELL TRAC CD3E TRBC1 TRBV12-3 TRAV29DV5 TRBV7-9 TRAV19 TRAV8-4 C3 KLRK1 NCR2 KIR2DS2 CD300LB TREM1 CD300E KLRD1 CD40LG ICAM2 ICAM3 PVR NECTIN2 COLEC12 CXADR IFITM1 ICAM1 JAML CD99 CD22 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 ICAM4 V1-11 VCAM1 ICAM5 IGKV2D-30 TREML1 V1-16 TREML4 V1-13 TREML2 IGHV1-69 HCST KIR3DL1 KIR3DL2 SIGLEC1 CD19 SIGLEC8 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PYRIMIDINE%REACTOME DATABASE ID RELEASE 76%110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 NTHL1 TDG MBD4 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 SMUG1 H2BC12 NEIL3 H2BC13 NEIL2 H3-4 H2BC14 POT1 H2AJ TERF2IP NEIL1 H2BC15 H2BC11 REGULATION OF COMMISSURAL AXON PATHFINDING BY SLIT AND ROBO%REACTOME DATABASE ID RELEASE 76%428542 Regulation of commissural axon pathfinding by SLIT and ROBO ROBO2 NELL2 ROBO1 SLIT1 SLIT3 SRC DCC SLIT2 NTN1 MTORC1-MEDIATED SIGNALLING%REACTOME%R-HSA-166208.3 mTORC1-mediated signalling MTOR RPS6 RRAGA RPS6KB1 RRAGC RHEB RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 RPTOR YWHAB EEF2K EIF4G1 MLST8 EIF4EBP1 FKBP1A SLC38A9 EIF4E EIF4B MAPK6 MAPK4 SIGNALING%REACTOME%R-HSA-5687128.3 MAPK6 MAPK4 signaling FOXO3 PRKACG PRKACB AGO3 AGO4 PAK3 AGO1 AGO2 CDC42EP5 KALRN CDC42EP3 CDC42EP2 PRKACA CDC42 PAK1 PSMD8 PSMD9 PSMD6 DNAJB1 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 CDC14B RAG2 PSMA3 RAG1 PSMA4 ETV4 PSMA1 PSMA2 MAPK6 NCOA3 PSME3 MAPK4 PSME4 SEPTIN7 PSME1 PSME2 UBA52 PSMD10 PSMB11 FOXO1 PSMD12 PSMD11 PSMD14 HSPB1 PSMD13 PSMA7 XPO1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CCND3 PSMB1 PSMF1 UBC PAK2 JUN PSMB8 CDC14A PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 TNRC6C PSMC1 MOV10 PSMC2 MYC RAC1 TNRC6A TNRC6B IGF2BP1 CDK1 MAPKAPK5 DEFECTIVE CYP27B1 CAUSES VDDR1B%REACTOME DATABASE ID RELEASE 76%5579027 Defective CYP27B1 causes VDDR1B CYP2R1 AMPLIFICATION OF SIGNAL FROM THE KINETOCHORES%REACTOME DATABASE ID RELEASE 76%141424 Amplification of signal from the kinetochores PPP2R1B KIF2C MIS12 PPP2R5E KIF2B NUP43 RANBP2 RPS27 DYNC1LI1 DYNC1LI2 B9D2 PPP2R5B SPC24 CDCA8 PPP2R5A SPC25 ERCC6L PPP2R5D SKA1 CENPE PPP2R5C SKA2 NUP37 ZWILCH KNTC1 NUF2 SGO1 NUDC SGO2 PPP2CA PMF1 PPP2CB INCENP CENPA CENPC BUB1B CENPT BUB3 CENPU SEC13 MAD2L1 PPP2R1A CENPH CENPI TAOK1 CENPK CENPL BUB1 CENPM NUP107 CENPN DYNLL2 CENPO CENPP CENPQ CENPS DYNC1I1 DYNLL1 CKAP5 CLIP1 KIF18A MAD1L1 BIRC5 MAPRE1 NDC80 ITGB3BP NUP160 PAFAH1B1 DYNC1I2 NUP85 SPDL1 XPO1 CENPF RANGAP1 CLASP2 NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 RCC2 NUP133 ZWINT AHCTF1 ZW10 NDEL1 KIF2A TRANSFER OF LPS FROM LBP CARRIER TO CD14%REACTOME DATABASE ID RELEASE 76%166020 Transfer of LPS from LBP carrier to CD14 LBP CD14 FORMATION OF THE BETA-CATENIN:TCF TRANSACTIVATING COMPLEX%REACTOME%R-HSA-201722.4 Formation of the beta-catenin:TCF transactivating complex CREBBP TRRAP LEO1 TCF7L2 TCF7L1 CTNNB1 TLE4 TLE3 TLE2 KMT2D TLE1 H2AX H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 TERT H2BC17 H2BC12 H2BC13 H3-4 H2BC14 H2AJ H2BC15 H2BC11 HDAC1 H3C15 MEN1 H2BS1 H2AZ1 H2BC9 H2AZ2 AXIN2 H4C9 H2BC8 H2BC5 H2BC3 RBBP5 H2BC1 ASH2L H2AC20 RUVBL1 MYC BCL9L KAT5 PYGO1 PYGO2 RUNX3 BCL9 CDC73 TCF7 SMARCA4 LEF1 DEFECTIVE SLC9A9 CAUSES AUTISM 16 (AUTS16)%REACTOME%R-HSA-5619052.1 Defective SLC9A9 causes autism 16 (AUTS16) SLC9A9 SIGNALING BY TGFB FAMILY MEMBERS%REACTOME%R-HSA-9006936.5 Signaling by TGFB family members ACVR1B ACVR2B ACVR2A DRAP1 ACVR1C SMAD6 CER1 NEDD4L UCHL5 BMP2 MTMR4 TGIF1 PMEPA1 CDK8 BAMBI PPP1CB TGIF2 STRAP PPP1R15A JUNB CBL SMAD1 USP9X SMAD7 MEN1 UBE2M AMHR2 ZFYVE16 UBA52 GDF2 SMAD9 SMAD5 BMPR1B BMPR1A ACVRL1 USP15 BMPR2 NOG XPO1 GREM2 UBB TFDP1 UBC TFDP2 RPS27A SKI RNF111 PPP1CC PARP1 NCOR2 NCOR1 MYC CCNK BMP10 PPP1CA CDKN2B SERPINE1 CCNT1 WWTR1 SMAD4 SMAD3 SMURF2 SNW1 SP1 CDK9 E2F5 CCNT2 UBE2D3 STUB1 UBE2D1 SKIL INHBB INHBA FURIN NEDD8 HDAC1 RBL1 E2F4 TRIM33 CHRDL1 FST PPM1A AMH FSTL1 FSTL3 TGFB1 CCNC SMURF1 ARHGEF18 CGN F11R PRKCZ TGFBR1 RHOA TGFBR2 FKBP1A SMAD2 PARD6A ATP1B4 PARD3 FOXH1 UREA CYCLE%REACTOME%R-HSA-70635.1 Urea cycle NMRAL1 ASS1 CPS1 NAGS SLC25A2 ASL SLC25A15 ARG2 ARG1 OTC PI3K AKT SIGNALING IN CANCER%REACTOME%R-HSA-2219528.2 PI3K AKT Signaling in Cancer FOXO3 MAPKAP1 ESR1 GAB1 TGFA MDM2 STRN PIK3CA GSK3A FLT3 LCK CD28 KIT FYN PRR5 RHOG VAV1 PDGFB PDGFRB HGF ERBB2 PDPK1 ESR2 PTPN11 CD86 CD80 RICTOR PIK3R1 AREG PIK3R2 FOXO4 TRAT1 NRG1 NRG2 PIK3AP1 PTEN NRG3 NRG4 EGF EPGN GSK3B HBEGF FOXO1 EGFR AKT2 MLST8 AKT1 BAD TSC2 KLB IRS1 MTOR PDGFRA CHUK IRS2 PIK3CB FGF1 FGF2 CASP9 FGF3 AKT1S1 FGF4 FGF6 FOXO6 FGF7 NR4A1 FGF9 RPS6KB2 PIK3CD CREB1 FGF20 RAC2 RAC1 FGF23 FGF22 FLT3LG PIK3R3 FRS2 GAB2 MET FGF16 FGF19 EREG FGF18 CDKN1A BTC CDKN1B FGFR4 SRC FGF10 AKT3 CD19 E2F MEDIATED REGULATION OF DNA REPLICATION%REACTOME%R-HSA-113510.3 E2F mediated regulation of DNA replication PPP2CA PPP2CB RB1 ORC5 PPP2R1B ORC4 TFDP1 ORC6 TFDP2 ORC1 ORC3 ORC2 PRIM2 E2F1 PRIM1 POLA1 POLA2 PPP2R1A CDK1 PPP2R3B MCM8 CCNB1 DEFECTIVE SLC6A3 CAUSES PARKINSONISM-DYSTONIA INFANTILE (PKDYS)%REACTOME DATABASE ID RELEASE 76%5660724 Defective SLC6A3 causes Parkinsonism-dystonia infantile (PKDYS) SLC6A3 TWIK-RELATED ALKALINE PH ACTIVATED K+ CHANNEL (TALK)%REACTOME DATABASE ID RELEASE 76%1299361 TWIK-related alkaline pH activated K+ channel (TALK) KCNK16 KCNK17 IGF1R SIGNALING CASCADE%REACTOME DATABASE ID RELEASE 76%2428924 IGF1R signaling cascade GAB1 PIK3CA FLT3 SOS1 AKT2 IRS4 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 NRAS FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 IGF1 FLT3LG FRS2 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 IGF2 PIK3C3 IGF1R FGFR4 PIK3R2 FGF10 SUMOYLATION OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 76%3232118 SUMOylation of transcription factors TP53 CDKN2A MTA1 PIAS1 MDM2 MITF HIC1 SUMO1 SUMO3 SUMO2 TFAP2B TFAP2C TP53BP1 SP3 FOXL2 PIAS4 PIAS3 UBE2I NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY%REACTOME%R-HSA-383280.1 Nuclear Receptor transcription pathway VDR NR1H2 RORA NR2C1 ESR1 NR2C2AP NR4A2 NR5A1 AR RXRA THRA HNF4A NR2E1 RXRB RARA PPARG NR1D2 PGR RXRG NR1D1 PPARA NRBP1 NR2C2 RARG RARB MED1 ESR2 PPARD NR2F1 NCOR2 NR0B2 NR4A1 NR2F6 NCOR1 HNF4G RORC ESRRA RORB ESRRB ESRRG THRB DNA DOUBLE STRAND BREAK RESPONSE%REACTOME DATABASE ID RELEASE 76%5693606 DNA Double Strand Break Response TP53 KPNA2 ATM SUMO1 BRCC3 BARD1 BAP1 BABAM1 BABAM2 BRCA1 UIMC1 H2AX RNF8 NSD2 APBB1 KDM4A H2BC21 KDM4B EYA1 H2BU1 EYA2 EYA3 EYA4 PPP5C BAZ1B H2BC17 H2BC12 H2BC13 H3-4 H2BC14 H2BC15 RAD50 H2BC11 MAPK8 ABL1 HERC2 H2BS1 UBXN1 TP53BP1 H2BC9 UBA52 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 RNF168 ABRAXAS1 UBB UBC RPS27A MRE11 MDC1 KAT5 UBE2V2 NBN PIAS4 CHEK2 UBE2N UBE2I SIGNALING BY FGFR IN DISEASE%REACTOME%R-HSA-1226099.4 Signaling by FGFR in disease GAB1 ZMYM2 PIK3CA PLCG1 SOS1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L STAT1 GTF2F1 CPSF6 GTF2F2 FGFR3 FGFR1 BAG4 MYO18A PIK3R1 BCR CUX1 LRRFIP1 STAT3 NCBP1 NCBP2 ERLIN2 STAT5A STAT5B HRAS FGF1 FGF2 FGFR2 FGF3 FGF4 FGF6 NRAS FGF7 FGF9 FGF20 FGF23 FGF22 FRS2 FGFR1OP2 GAB2 TRIM24 FGF16 FGF18 CEP43 FGFR4 FGF10 TYROSINE CATABOLISM%REACTOME%R-HSA-8963684.1 Tyrosine catabolism GSTZ1 HGD FAH TAT BETA-CATENIN INDEPENDENT WNT SIGNALING%REACTOME DATABASE ID RELEASE 76%3858494 Beta-catenin independent WNT signaling PRKG1 PLCB3 PLCB1 PRKCB PLCB2 NLK FZD8 PPP3R1 FZD7 PRKG2 WNT11 PDE6B PDE6A FZD3 FZD5 PDE6G FZD6 DAAM1 NFATC1 GNAO1 ITPR1 ITPR2 GNG10 ITPR3 GNG12 GNG11 ARRB2 GNG13 GNB2 RAC3 GNB1 GNB4 GNB3 GNB5 CLTC GNGT1 GNGT2 CALM1 PRKCG WNT5B ROR1 ROR2 PRICKLE1 GNG3 WNT1 WNT4 FZD1 GNG2 RYK GNG5 GNG4 GNG7 GNG8 DVL1 UBA52 DVL3 UBB PRKCA SCRIB UBC CAMK2A RPS27A VANGL2 TNRC6C MOV10 RAC1 TNRC6A TNRC6B TCF7 LEF1 TCF7L2 TCF7L1 SMURF2 CTNNB1 PFN1 AGO3 AGO4 AGO1 AGO2 FZD4 CLTA AP2A1 CLTB AP2A2 AP2M1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 AP2S1 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 AP2B1 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 WNT5A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RAC2 SMURF1 RHOA DVL2 PPP3CA PPP3CB PARD6A GNAT2 MAP3K7 TRANSCRIPTIONAL ACTIVATION OF CELL CYCLE INHIBITOR P21%REACTOME%R-HSA-69895.3 Transcriptional activation of cell cycle inhibitor p21 TP53 PCBP4 CDKN1A ZNF385A RUNX3 REGULATES WNT SIGNALING%REACTOME DATABASE ID RELEASE 76%8951430 RUNX3 regulates WNT signaling MYC TCF7L2 TCF7L1 CCND1 RUNX3 CTNNB1 TCF7 LEF1 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR4%REACTOME%R-HSA-5654228.2 Phospholipase C-mediated cascade; FGFR4 KLB FGF1 FGF2 PLCG1 FGF4 FGF6 FGF9 FGF20 FGF23 FGF16 FGF19 FGF18 FGFR4 DEFECTIVE SLC26A2 CAUSES CHONDRODYSPLASIAS%REACTOME%R-HSA-3560792.2 Defective SLC26A2 causes chondrodysplasias SLC26A2 FREE FATTY ACIDS REGULATE INSULIN SECRETION%REACTOME%R-HSA-400451.2 Free fatty acids regulate insulin secretion GNA11 FFAR1 PLCB3 PLCB1 PLCB2 GNA14 GNAQ GNA15 CD36 ACSL3 PROTON-COUPLED NEUTRAL AMINO ACID TRANSPORTERS%REACTOME%R-HSA-428559.1 Proton-coupled neutral amino acid transporters SLC36A2 SLC36A1 GSD XV%REACTOME%R-HSA-3814836.2 GSD XV GYG1 GYS1 PEXOPHAGY%REACTOME%R-HSA-9664873.2 Pexophagy NBR1 UBB UBA52 UBC SQSTM1 RPS27A MAP1LC3B PEX5 ATM EPAS1 USP30 PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR%REACTOME%R-HSA-392851.2 Prostacyclin signalling through prostacyclin receptor GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 PTGIR GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 GNGT1 GNGT2 GNG10 GNAS DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MLH1%REACTOME DATABASE ID RELEASE 76%5545483 Defective Mismatch Repair Associated With MLH1 PMS2 MLH1 CATECHOLAMINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%209905 Catecholamine biosynthesis TH DDC PNMT DBH ANTIGEN PROCESSING: UBIQUITINATION & PROTEASOME DEGRADATION%REACTOME DATABASE ID RELEASE 76%983168 Antigen processing: Ubiquitination & Proteasome degradation ATG7 UBE2V1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 KBTBD13 ASB13 ASB14 RNF213 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 FBXL21P ASB15 ASB16 FBXL20 MIB2 ASB10 FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 BTRC SKP1 CBLB DCAF1 HERC4 RNF115 FBXW11 HERC3 RNF114 HERC1 HERC6 RNF126 HECW2 CBLL2 TRIM11 ANAPC13 UBE2J1 RNF217 FBXL7 HACE1 MEX3C UBAC1 UBA3 DZIP3 RNF220 UBE2M DET1 LRSAM1 UBA52 TRIM9 TRIM4 ARIH2 RNF144B RNF138 RNF130 FBXL18 RLIM TRIP12 UBE2D4 UBE3C CUL1 UBE3D LTN1 RNF19B UBE3A UBR4 UBE3B UBB NPEPPS RNF19A AREL1 UBE2E2 UBC UBE4A TRAIP RPS27A UBA5 RNF111 UBR2 UBR1 LONRF1 GLMN UBOX5 UBE2U RNF182 UBE2O TPP2 BLMH TRIM71 RNF14 UFL1 UBE2V2 UBE2Q1 TRIM69 UNKL DTX3L PJA2 PJA1 TRAF7 THOP1 TRIM50 MGRN1 RNF6 RNF4 RCHY1 ZNRF1 ZNRF2 HECTD1 HECTD2 ELOB HECTD3 ELOC TRIM41 SMURF2 RNF25 TRIM39 LNX1 TRIM36 TRIM37 SIAH1 RBCK1 UBA7 UBE2D2 UBE2D3 UBE2L6 NEDD4 HERC5 MKRN1 STUB1 ANAPC7 UBE2C UBE2E1 UBE2D1 TRIM63 ANAPC10 ANAPC11 CDC23 HUWE1 UBE2S CDC26 SOCS1 CDC16 FBXO32 CDC27 UBE2K ANAPC4 ANAPC5 MYLIP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 TRIM21 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 TRIM32 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 CUL5 PSMC1 PSMC2 KCTD6 KEAP1 UBE2B FBXO4 FBXO6 RNF123 UBE2Z UBE2L3 UBE2Q2 FBXW4 FBXW5 SIAH2 FBXW10 UBE2E3 FBXW7 CDC34 FBXW9 UBE2R2 FBXW2 UBA6 NEDD4L UBE2J2 UBE2H UBE2G1 UBE2A UBE2G2 LRRC41 RNF41 UBE2W PRKN UBA1 RNF34 FBXL3 FBXL5 SH3RF1 CUL2 VHL HERC2 WWP1 CDC20 CUL7 RBX1 SKP2 LNPEP FZR1 ITCH LRR1 CCNF FBXO7 FBXO9 WSB1 FBXO2 SOCS3 CUL3 FBXL8 FBXL4 RBBP6 GAN KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 KBTBD8 SPSB4 FBXO27 FBXO21 FBXO22 FBXW12 FBXW8 FBXO17 KBTBD7 FBXO15 LMO7 FBXO10 FBXO11 KLHL41 KCTD7 SMURF1 KLHL42 KLHL11 KLHL13 FBXO44 FBXO41 FBXO40 BTBD1 UBE2N NETRIN MEDIATED REPULSION SIGNALS%REACTOME%R-HSA-418886.1 Netrin mediated repulsion signals UNC5A SRC UNC5B DCC PTPN11 UNC5C UNC5D NTN1 N-GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS-GOLGI%REACTOME%R-HSA-975576.1 N-glycan antennae elongation in the medial trans-Golgi CGA FUT8 MGAT3 MAN2A1 MGAT5 ST3GAL4 MGAT2 ST6GAL1 B4GALT2 MGAT4C B4GALT3 FUCA1 MGAT4A MGAT4B ST8SIA6 B4GALT6 B4GALT4 B4GALT1 ST8SIA2 B4GALT5 CHST10 LHB CHST8 ST8SIA3 MAN2A2 FUT3 MYD88-INDEPENDENT TLR4 CASCADE%REACTOME%R-HSA-166166.2 MyD88-independent TLR4 cascade TAB1 UBE2V1 PPP2R1B MAP2K6 CASP8 FOS RIPK1 PPP2R5D FADD HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 TANK PPP2CA PPP2CB UBE2D2 UBE2D3 TBK1 PTPN11 PPP2R1A IKBKE UBE2D1 BTRC IRF3 RIPK3 TRAF3 NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 NFKBIB FBXW11 SAA1 TICAM2 LY96 TICAM1 CD14 TLR4 IRF7 BIRC2 UBA52 MAP2K1 BIRC3 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA RELA RPS27A IKBKG MAPK9 NFKB2 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 COPI-DEPENDENT GOLGI-TO-ER RETROGRADE TRAFFIC%REACTOME%R-HSA-6811434.1 COPI-dependent Golgi-to-ER retrograde traffic KIFC1 KDELR3 KIF2C KIF2B CENPE SURF4 KIF26A KIF26B COPE USE1 KIF3A KIF28P KIF5C KIF5B KIF5A KIF21A ARF3 KIF21B TMED3 KIFAP3 TMED2 ARF4 TMED7 ARF1 TMED9 KIF16B KIF20A KIF20B ARFGAP3 ARFGAP1 ARFGAP2 NAPA NAPB SEC22B KLC1 RAB1A STX18 KLC4 COPZ2 NAPG KLC3 RAB1B KLC2 KIF3B COPZ1 RACGAP1 KIF3C BNIP1 GBF1 KIF18A KIF18B ARF5 KIF4B KIF4A NBAS COPG2 COPG1 KDELR1 KIF12 ARCN1 KIF11 NSF KIF15 KIF19 KIF13B RINT1 KIF1C KIF1B KIF1A COPB2 COPA TMED10 KIF25 KIF23 COPB1 KIF22 KIF6 KIF27 ZW10 KIF9 KIF2A KIFC2 KDELR2 RHOQ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013406 RHOQ GTPase cycle CFTR FNBP1 DLC1 IQGAP3 TFRC JUP SNAP23 PLEKHG3 ARHGAP1 ARHGAP5 STEAP3 ARHGAP35 PREX1 SYDE1 OPHN1 OBSCN CDC42EP3 CDC42EP2 WWP2 RAB7A ARHGAP33 WASL IQGAP1 GFOD1 CDC42EP1 CDC42 RHOQ PAK1 VAMP3 GOPC ARHGAP17 GIT1 SLC1A5 GIT2 ARHGAP21 VANGL1 DEPDC1B SRGAP2 ARHGEF9 ARHGEF7 PAK4 TRIP10 CAV1 STOM ARHGAP26 MPP7 SLC4A7 ARHGAP32 DIAPH3 SCRIB PAK2 CDC42BPB CDC42BPA CPNE8 LAMTOR1 ARL13B CDC42EP4 ITSN1 GJA1 GRB2 EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963640.3 GRB2 events in ERBB2 signaling NRG1 NRG2 NRG3 HRAS NRG4 ERBB2 SOS1 EGF NRAS HBEGF EGFR EREG BTC REGULATION OF CYTOSKELETAL REMODELING AND CELL SPREADING BY IPP COMPLEX COMPONENTS%REACTOME%R-HSA-446388.1 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components LIMS1 PARVA ARHGEF6 ACTN1 PXN TESK1 PARVB RSU1 LOSS OF FUNCTION OF SMAD4 IN CANCER%REACTOME DATABASE ID RELEASE 76%3304347 Loss of Function of SMAD4 in Cancer SMAD4 SMAD3 SMAD2 TOLL LIKE RECEPTOR 9 (TLR9) CASCADE%REACTOME DATABASE ID RELEASE 76%168138 Toll Like Receptor 9 (TLR9) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 TLR7 MAPK8 NFKBIB FBXW11 IRAK4 SAA1 MYD88 EEA1 TICAM2 LY96 TICAM1 CD14 TLR4 IRF7 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 PIK3R4 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 RBSN IRAK2 S100A12 ATF2 RIPK2 TLR9 PIK3C3 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 DEFECTIVE SLC34A2 CAUSES PULMONARY ALVEOLAR MICROLITHIASIS (PALM)%REACTOME%R-HSA-5619045.1 Defective SLC34A2 causes pulmonary alveolar microlithiasis (PALM) SLC34A2 PEPTIDE HORMONE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%209952 Peptide hormone biosynthesis CGB8 INHBB INHBA INHBC POMC INHBE LHB TSHB INHA PCSK1 CGA FSHB MPS IIIC - SANFILIPPO SYNDROME C%REACTOME DATABASE ID RELEASE 76%2206291 MPS IIIC - Sanfilippo syndrome C HGSNAT DEX H-BOX HELICASES ACTIVATE TYPE I IFN AND INFLAMMATORY CYTOKINES PRODUCTION%REACTOME%R-HSA-3134963.2 DEx H-box helicases activate type I IFN and inflammatory cytokines production DHX36 MYD88 RELA DHX9 NFKB1 NFKB2 IRF7 CTLA4 INHIBITORY SIGNALING%REACTOME%R-HSA-389513.1 CTLA4 inhibitory signaling PPP2CA PPP2CB PPP2R1B PPP2R5E CTLA4 PPP2R5B PTPN11 CD86 PPP2R5A LCK CD80 PPP2R5D PPP2R1A PPP2R5C FYN AKT2 AKT1 LYN YES1 AKT3 PROTEIN METHYLATION%REACTOME%R-HSA-8876725.2 Protein methylation ETFBKMT VCPKMT EEF1AKMT2 EEF1AKMT1 HSPA8 ETFB VCP EEF1A1 EEF2 METTL22 PRMT3 METTL21A KIN CALM1 CAMKMT RPS2 EEF2KMT NEGATIVE FEEDBACK REGULATION OF MAPK PATHWAY%REACTOME DATABASE ID RELEASE 76%5674499 Negative feedback regulation of MAPK pathway RAF1 MAP2K1 BRAF MAP2K2 MAPK1 MAPK3 LYSOSPHINGOLIPID AND LPA RECEPTORS%REACTOME DATABASE ID RELEASE 76%419408 Lysosphingolipid and LPA receptors S1PR1 S1PR3 S1PR2 S1PR5 S1PR4 PLPPR1 PLPPR2 LPAR5 PLPPR3 LPAR1 PLPPR4 LPAR2 LPAR3 PLPPR5 PKA ACTIVATION%REACTOME DATABASE ID RELEASE 76%163615 PKA activation PRKAR2B NBEA ADCY4 PRKACG ADCY3 PRKACB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY9 ADCY5 PRKAR1B PRKAR1A PRKACA PRKAR2A CALM1 DEFECTIVE TPR MAY CONFER SUSCEPTIBILITY TOWARDS THYROID PAPILLARY CARCINOMA (TPC)%REACTOME DATABASE ID RELEASE 76%5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 GCK NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 GCKR NUP155 NUP214 NUP153 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 CONJUGATION OF SALICYLATE WITH GLYCINE%REACTOME%R-HSA-177128.1 Conjugation of salicylate with glycine ACSM5 ACSM4 ACSM2B GLYATL3 GLYAT GLYATL2 GLYATL1 ACSM2A LXRS REGULATE GENE EXPRESSION LINKED TO LIPOGENESIS%REACTOME%R-HSA-9029558.1 LXRs regulate gene expression linked to lipogenesis NR1H2 FASN ANGPTL3 RXRA RXRB SCD NRIP1 NR1H3 MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS%REACTOME%R-HSA-174490.2 Membrane binding and targetting of GAG proteins UBB MVB12B UBC UBAP1 MVB12A RPS27A NMT2 VPS28 VPS37C gag VPS37D VPS37A VPS37B UBA52 TSG101 NUCLEOTIDE SALVAGE%REACTOME%R-HSA-8956321.1 Nucleotide salvage HPRT1 TYMP ADA TK1 UPP2 UCKL1 UCK2 UPP1 UCK1 TK2 PUDP GMPR2 ADK GMPR AMPD1 AMPD2 CDA AMPD3 DCK APRT ADAL DGUOK PNP CRENOLANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702581.1 crenolanib-resistant FLT3 mutants FLT3 SYNTHESIS OF HEPOXILINS (HX) AND TRIOXILINS (TRX)%REACTOME%R-HSA-2142696.1 Synthesis of Hepoxilins (HX) and Trioxilins (TrX) ALOX12 DISEASES ASSOCIATED WITH GLYCOSYLATION PRECURSOR BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%5609975 Diseases associated with glycosylation precursor biosynthesis GNE NEU1 PGM1 MPI GALK1 CTSA GALT GALE GFPT1 PMM2 SRD5A3 DOLK NUS1 DHDDS DPM1 DPM2 GLB1 DPM3 MEIOSIS%REACTOME DATABASE ID RELEASE 76%1500620 Meiosis BLM CDK2 ATM ATR MLH1 BRCA1 H2AX H2AB1 FKBP6 H2AC19 H2AC14 PRDM9 H2BC21 H2BU1 H3-3B H3C8 TOP3A H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 RBBP8 H2BC17 H2BC12 H2BC13 RPA1 H3-4 H2BC14 POT1 RPA2 H2AJ TERF2IP H2BC15 RAD50 RPA3 MSH4 H2BC11 MSH5 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SPO11 SYCP1 HSPA2 SYNE2 SMC3 SYNE1 H3C15 SUN2 SUN1 TEX12 TEX15 SMC1B DMC1 H2BS1 PSMC3IP MND1 RAD21 MLH3 REC8 H2AZ1 SYCP3 H2BC9 STAG1 H2AZ2 STAG2 H4C9 H2BC8 H2BC5 SMC1A H2BC3 H2BC1 H2AC20 LMNB1 CDK4 BRCA2 MRE11 RAD51 NBN RAD51C UBE2I ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONE GENES%REACTOME%R-HSA-381183.3 ATF6 (ATF6-alpha) activates chaperone genes HSP90B1 ATF6 HSPA5 NFYA DDIT3 NFYB NFYC CALR ATF4 TOLL LIKE RECEPTOR TLR6:TLR2 CASCADE%REACTOME%R-HSA-168188.1 Toll Like Receptor TLR6:TLR2 Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN RPS27A CREB1 MAPK14 MAPK11 ATF2 FOS S100A1 HMGB1 TIRAP mip BTK porB TLR6 CD36 PELI1 SOCS1 IRAK4 SAA1 MYD88 LY96 FGB FGA CD14 TLR4 FGG ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 FC EPSILON RECEPTOR (FCERI) SIGNALING%REACTOME%R-HSA-2454202.1 Fc epsilon receptor (FCERI) signaling TAB1 V1-20 UBE2V1 IGKV2D-40 IGHV3-11 PPP3R1 IGHV3-13 IGHV1-46 NFATC1 IGHV V5-4 V5-1 SYK FYN V5-6 MAPK1 IGLV3-19 MAPK3 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 VAV2 BTRC IGLV SKP1 V3-4 V3-3 PIK3R2 V3-2 IGKV1D-39 IGKV1D-33 FBXW11 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 NFATC2 IGLV6-57 IGLV2-14 UBA52 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 CUL1 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 UBB IGKV3-20 IGHV4-34 IGHV1-2 UBC IGHV4-39 RPS27A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 LAT2 IGHE TEC FCER1G UBE2D2 LCP2 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 MAP2K4 IKBKB PSMB3 PSMB1 PSMF1 MAP2K7 PAK2 CHUK PSMB8 PSMB9 PIK3CB SEM1 IKBKG PSMC5 MAPK9 MAP3K1 PSMC6 PSMC3 RASGRP2 MAPK10 PSMC4 RASGRP1 PSMC1 PSMC2 GAB2 GRAP2 CDC34 VAV3 BCL10 VAV1 ITPR1 ITPR2 ITPR3 PDPK1 PIK3R1 PAK1 NFKB1 CALM1 MAPK8 FCER1A MS4A2 ITK TXK LYN JUN CARD11 NFATC3 MALT1 RASGRP4 PRKCQ PIK3CA PLCG1 SOS1 FOS BTK AHCYL1 IGHV3-23 IGLV2-8 IGKV1-16 HRAS IGKV1-17 IGKV1-12 NFKBIA IGHV3-7 RELA IGHV3-9 IGHV3-30 V2-17 IGHV3-33 NRAS V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 PPP3CA TRAF6 PPP3CB UBE2N PLCG2 TAB3 MAP3K7 TAB2 VXPX CARGO-TARGETING TO CILIUM%REACTOME%R-HSA-5620916.2 VxPx cargo-targeting to cilium CNGA2 CNGA4 GBF1 EXOC4 RAB11A EXOC3 EXOC6 RHO EXOC5 ARF4 CNGB1 EXOC2 ASAP1 EXOC1 RAB11FIP3 RAB8A EXOC8 EXOC7 PKD2 RAB3IP PKD1 LOSS OF MECP2 BINDING ABILITY TO 5MC-DNA%REACTOME%R-HSA-9022538.1 Loss of MECP2 binding ability to 5mC-DNA HDAC1 SIN3A KERATAN SULFATE DEGRADATION%REACTOME DATABASE ID RELEASE 76%2022857 Keratan sulfate degradation GNS LUM HEXB OMD KERA HEXA GLB1L PRELP ACAN OGN GLB1 FMOD DEPURINATION%REACTOME%R-HSA-73927.1 Depurination H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 MPG H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 NEIL3 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 SEROTONIN NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-181429.3 Serotonin Neurotransmitter Release Cycle SNAP25 SYT1 UNC13B RAB3A SYN3 CPLX1 SYN2 RIMS1 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 VAMP2 PPFIA2 SLC18A2 SYN1 CELLULAR RESPONSE TO HEAT STRESS%REACTOME DATABASE ID RELEASE 76%3371556 Cellular response to heat stress CREBBP SIRT1 NUP42 NUP43 HSPA12A RAE1 HSPA12B RANBP2 ATM RPS19BP1 NUP35 NUP37 HSPA9 HSPA5 ATR HSPA4 MAPK1 HSPA7 HSPA6 MAPK3 HSPB8 HSP90AA1 HSPA8 EP300 YWHAE BAG4 SEC13 RPA1 RPA2 NUP107 NUP188 RPA3 HSP90AB1 HSBP1 DNAJB1 HSF1 HSPA1L HDAC6 PTGES3 HSPA2 NUP210 FKBP4 HSPA1B NUP93 VCP POM121 NUP205 GSK3B AAAS RPTOR NUP160 POM121C NUP85 TPR MLST8 NUP88 NUP155 NUP214 NUP153 CAMK2B MTOR CAMK2D HSPA4L MAPKAPK2 HSPH1 CAMK2A ST13 CRYAB HSPA14 AKT1S1 HSPA13 CAMK2G HIKESHI NUP62 EEF1A1 NDC1 BAG5 BAG2 NUP133 BAG3 BAG1 DNAJC2 HSPA1A DNAJC7 NUP50 DNAJB6 NUP54 CCAR2 DISASSEMBLY OF THE DESTRUCTION COMPLEX AND RECRUITMENT OF AXIN TO THE MEMBRANE%REACTOME%R-HSA-4641262.3 Disassembly of the destruction complex and recruitment of AXIN to the membrane PPP2R1B PPP2R5E WNT1 FZD5 FZD1 CTNNB1 PPP2R5B PPP2R5A CSNK1G2 GSK3B PPP2R5D CAV1 PPP2R5C DVL1 AXIN1 AMER1 DVL3 FRAT1 FRAT2 WNT8A WNT8B PPP2CA PPP2CB APC WNT3A PPP2R1A CSNK1A1 LRP5 DVL2 LRP6 APC TRUNCATION MUTANTS HAVE IMPAIRED AXIN BINDING%REACTOME%R-HSA-5467337.1 APC truncation mutants have impaired AXIN binding PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 ADENYLATE CYCLASE ACTIVATING PATHWAY%REACTOME%R-HSA-170660.1 Adenylate cyclase activating pathway ADCY8 ADCY7 GNAL ADCY9 ADCY6 ADCY5 ADCY4 ADCY3 ADCY2 ADCY1 SIGNAL REGULATORY PROTEIN FAMILY INTERACTIONS%REACTOME%R-HSA-391160.2 Signal regulatory protein family interactions SIRPA SIRPG PTK2 SKAP2 TYROBP FYB1 PTPN6 CD47 SIRPB1 PTK2B PTPN11 SPERM MOTILITY AND TAXES%REACTOME DATABASE ID RELEASE 76%1300642 Sperm Motility And Taxes KCNU1 CATSPER1 CATSPERB CATSPER3 CATSPERD CATSPER2 CATSPERG CATSPER4 HVCN1 RELEASE OF HH-NP FROM THE SECRETING CELL%REACTOME%R-HSA-5362798.1 Release of Hh-Np from the secreting cell GPC5 DISP2 SCUBE2 SHH ADAM17 DHH IHH NOTUM METABOLISM OF PROTEINS%REACTOME%R-HSA-392499.7 Metabolism of proteins CREBBP F8 SENP1 GSK3A TRIM27 HGS RAB5A GSN RAB7A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 ISL1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL SEMA5A RPL36 RPL35 RPLP2 RPL38 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 GSPT1 RPS15A RPL14 RPS3 RPL13 RPS2 PARS2 RPL15 EARS2 RPL18 LARS2 RPL17 PPA2 RPL19 TARS2 RPL39L AARS2 RPL41 HARS2 DAG1 RPL35A EIF5 RPL23A RPL3L TRAM1 RPS26 GFM2 RPS25 SRP54 FARS2 RPS28 RPS27 SSR4 RPS29 SSR2 RPL27A SSR3 SRP9 RPL22L1 RPS20 MRRF SRP72 FAU TLN1 RPS21 SRP68 SRP19 RPL26L1 MTFMT RPS24 YARS2 RPS23 NARS2 RARS2 CARS2 VARS2 EIF2B5 EIF2B4 EIF2B3 EIF2B2 SIAH1 EIF2B1 EIF5B H2AX MARS2 H2AB1 DARS2 H2AC19 SARS2 MTRF1L CHD3 MTIF2 TTF1 MTIF3 EIF4H ACTB IARS2 H2AC14 WARS2 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 KAT2A H2BC15 DPH1 DPH2 H2BC11 DPH3 DPH5 DNAJC24 DPH6 DPH7 HDAC2 HDAC1 H3C15 MTA1 H2BS1 RBBP7 H2AZ1 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 IFIH1 SFTPC RNF135 MAVS DDX58 TRIM25 IKBKG PAX6 HDAC3 DCAF7 CCT6B TUBB6 TUBB3 TUBB1 FBXO4 LONP2 FBXO6 MRTFA RGS9 RGS6 RGS7 CDCA8 FBXW4 FBXW5 FBXW10 CSNK2A1 FBXW7 FBXW9 CSNK2A2 TUBA4B FBXW2 XRN2 PRMT3 CSNK2B GAPDHS FKBP9 ARL2 GNG10 TBCD TBCC TBCB LRRC41 TBCA GNG12 GNG11 INCENP GNG13 CCT6A GNB2 GNAQ GNB1 TBCE GNB4 PDCL GNB3 SKIV2L FBXL3 GNB5 FBXL5 TUBA8 WRAP53 GNGT1 TUBA1C TUBA1B GNGT2 KIF13A CCT3 VBP1 SPHK1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 PFDN5 PFDN6 TUBAL3 USP11 MSRA GBA GNA14 PCMT1 TUBA3E MSRB2 MSRB3 AP3M1 GNG3 MSRB1 MEN1 GNA15 TUBA3D GNG2 TUBA3C GNG5 GNG4 GNG7 GNA11 GNG8 CCT8 CCT5 CCT4 NOP56 ARFGEF2 STAT3 RGS11 RANGAP1 DAXX RWDD3 UBA2 SAE1 KLK3 ALG2 B4GALT1 SDC2 GPC3 ST3GAL3 SKP2 B4GALT2 B4GALT3 B3GNT7 B3GNT4 B3GNT3 B3GNT2 B4GALT6 VNN1 B4GALT4 VNN2 B4GALT5 NUS1 DHDDS EIF4EBP1 ICMT FOLR2 EIF4E EIF4B MGAT3 RRAGA SATB1 COL7A1 CHST10 CHST8 LMAN1 DDX5 CD109 YKT6 UBA3 UBE2M HNRNPK MYC PGAP1 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 LYPD8 B3GALNT2 LYPD6B PIGS TCF7L2 PIGU PIGT SMAD4 PIGO PIGN PIGP SMAD3 PIGZ SMURF2 PIGW PIGV CTNNB1 PIGY PIGX LRRC49 PIGC PIGB PIGA PIGK PIGM PIGL CHST4 TAF9B PIGG PIGF PIGH TTLL7 TTLL6 TAF10 TTLL5 TTLL4 TTLL3 TTLL2 TTLL1 ETFBKMT TTLL9 TTLL8 LY6K POFUT2 OTUD5 AGTPBP1 LY6D LY6H UBE2D2 LY6E UBE2D3 SPRN ETFB TNFAIP3 SPACA4 UBE2L6 NICN1 MDGA2 MDGA1 RECK NRN1 IKBKE ART3 ART4 NTNG1 NTNG2 CYLD GPAA1 RAB22A B3GNTL1 TRAF3 CD52 KIN UBE2K PRND CAMKMT CNTN5 SERPINC1 ALPL PROS1 CNTN3 CNTN4 ALPG VCPKMT GALNT9 GALNT8 TEX101 RAB40A RAB40B RAB40C FGA GALNT7 SERPIND1 GALNT6 F10 GALNT5 GALNT4 TPGS1 TPGS2 ALG10B FGG GPLD1 GP2 GALNTL5 F5 GALNTL6 ASGR1 F7 ASGR2 PRSS21 PROC FN3KRP F9 GCNT1 METTL21A GCNT3 GCNT4 GCNT7 AGBL5 AGBL4 PRSS41 AGBL1 AGBL3 A4GNT NCOA1 AGBL2 EEF1AKMT2 EEF1AKMT1 RAB3B NCOA2 RAB3C RAB42 LARGE2 TECTA TECTB RAB2B VASH2 VASH1 RAB34 EEF1B2 TTLL13P TOP2B TOP1 EEF1A1 FN3K EEF1G PLET1 EEF1D CPM EEF1A2 PSCA EEF1A1P5 RTN4RL2 EEF2 METTL22 PTP4A2 RTN4RL1 TTL RAB20 RAB25 RAB26 SVBP RAB23 EEF2KMT CES1 RAB29 RAB15 RAB19 RAB17 TTLL10 TTLL11 TTLL12 UMOD OTOA RAET1G VNN3 RAET1L IZUMO1R B3GNT9 PPP2R5B B3GNT8 CEACAM7 SULT1A3 NRN1L B3GNT6 CEACAM5 B3GNT5 LY6G6C LY6G6D LSAMP GALNT11 GALNT14 GALNT13 GALNT16 GALNT15 GALNT18 GALNT17 GALNT10 ALG10 NTM ULBP2 POMGNT2 OPCML NEGR1 XPNPEP2 POMK APOB ZDHHC2 DMBT1 LMCD1 NAPSA CCDC59 PGA3 PGA5 PGA4 ADGRF5 CALM1 DYNLL2 LARS1 AIMP1 AIMP2 EPRS1 QARS1 EEF1E1 KARS1 RARS1 ASNS MARS1 DARS1 NPPA SARS1 FN1 IARS1 LMNA SYVN1 KIF5C KIF5B KIF5A GATA6 GATA4 GATA3 HDAC7 CBX5 UBXN1 NGLY1 RNF139 MLEC UGGT2 UGGT1 MARCHF6 EDEM3 PDIA3 EDEM1 AMFR RNF103 TRIM13 CALR ENGASE HLA-B ATF6 EIF2AK3 HERPUD1 PAPPA2 C4A IGFALS ERN1 CPB2 CREB3 CAPZB CREB3L4 CREB3L1 SIN3A CREB3L2 IGFBP2 IGFBP6 PAPPA KLK1 CREBRF DCSTAMP PCSK1 CDX2 GPR119 DPP4 SPCS3 SPCS2 SPCS1 LEP SEC11A CAPZA1 SEC11C CAPZA2 EIF5A EIF5A2 DHPS DOHH PLA2G4B PCSK9 IGFBP1 CREB3L3 KLF4 FBXO32 CSF1 TNC APOA2 DMP1 APOA1 LGALS1 APOA4 CDH2 EVA1A APOA5 CCN1 CHGB IGFBP5 IGFBP4 APLP2 SHISA5 PDIA6 MXRA8 SPARCL1 SCG3 SCG2 SAR1B LTBP1 HSP90B1 STC2 IGFBP7 AMELX WFS1 AMBN FUCA2 APOE TMEM132A BMP4 HRC CALU GPIHBP1 MELTF FBN1 MBTPS1 SERPINA10 MSLN CHRDL1 PRSS23 BMP15 QSOX1 AHSG MEPE DNAJC3 ALB P4HB RCN1 VGF MBTPS2 ENAM AMTN VWA1 USP7 FAM20C FAM20A DDB1 MFGE8 MATN3 ITIH2 AFP COPS7B FSTL1 COPS7A FSTL3 CST3 CUL4A SPP2 COPS3 APOL1 GOLM1 COPS6 COPS5 LAMB2 NUCB1 ERCC8 NOTUM PNPLA2 COPS8 CDC73 CUL4B CTR9 SMAD2 WDR61 RTF1 LEO1 PAF1 POMT2 POMT1 ST6GALNAC2 RPN2 PRKCSH TUSC3 RPN1 MAGT1 FUT8 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 SLC35A1 SLC35C1 RING1 MUC13 CKAP4 KTN1 TFG DYNC1LI1 DYNC1LI2 ARF3 ARF4 ARF1 SERPINA1 CHM AREG EXOC8 EXOC7 COPZ2 COPZ1 EXOC4 EXOC3 EXOC6 EXOC5 EXOC2 VAMP2 ARF5 EXOC1 USO1 GGA2 GGA1 TRIM28 GGA3 LMAN2 STX5 CHML TRAPPC10 ARCN1 RAB3A RAB43 RAB41 RAB32 RAB30 L3MBTL2 RAB31 RAB36 RAB35 RAB38 GRIA1 RAB5B RAB5C RAB6A RAB6B TRAPPC2 ANKRD28 TRAPPC3 SEC16B RAB4A TRAPPC1 BMI1 TRAPPC4 SEC16A TRAPPC5 SATB2 TRAPPC9 CNIH1 CNIH2 CNIH3 MCFD2 ARRB1 ARRB2 PPP6C PPP6R1 PPP6R3 RNF2 ARFGAP3 SPTB ARFGAP1 BET1L ARFGAP2 SEC22B SEC22A SEC22C RAB1A SEC23A RAB1B RAB21 PHC2 PHC1 SEC24B SEC24A RAB10 PHC3 RAB14 RAB12 RAB13 RAB18 SEC24D SEC24C FOLR1 BET1 KDELR1 GOLGA2 ZNF350 COG8 COG7 COG6 LMAN1L COG5 COG4 COG3 COG2 COG1 ANK2 ANK3 ANK1 PCGF2 PREB KDELR2 KDELR3 CFTR SPTBN4 SPTBN5 LMAN2L TGFA TGOLN2 SCFD1 SEC31A SPTBN2 RAB39A MYO5A RAB27A RAB39B RAB27B STAM TF CTSZ MIA2 MIA3 TMED3 TMED2 TMED7 CTSC RAB8B SEC13 TMED9 RAB33A RAB33B RAB7B NAPA NAPB STX17 NEDD8 NAPG CD59 DYNC1I1 CD55 GBF1 RAB11A WDR5 RAB11B SEC23IP CAPZA3 RAB9A COPG2 COPG1 ACTR10 RAB9B RBBP5 NSF TRAPPC2L TBC1D20 STAM2 COPB2 COPA TMED10 COPB1 SPTA1 MAN2A2 KCTD6 CBX8 CBX4 CBX2 TMEM115 COPE THBS1 MAN1A2 MAN1A1 ERO1A TRAPPC6A TRAPPC6B GORASP1 CALB1 NAT8B BACE1 APCS TSPAN33 TSPAN5 DCTN6 SNCA DCTN5 ODAM SNCAIP DCTN1 SORL1 GOSR2 TSPAN15 DCTN4 TSPAN14 GOSR1 NAT8 TGFBI INS ITM2B SMC5 PARK7 SMC6 SMC3 HERC2 MAN1C1 DDX17 NSMCE3 NSMCE2 NSMCE1 GALNT2 MITF HIC1 EID3 GALNT1 RAD21 ZBED1 TP53BP1 XRCC4 STAG1 STAG2 SP3 ZNF131 SENP5 FOXL2 SMC1A SENP2 SAFB RNF168 NSMCE4A SP100 UHRF2 CASP8AP2 NOP58 MBD1 RAD52 AURKB HIPK2 NCOR2 MANEA HSPA5 SFTPA2 EIF4A2 EIF4A1 NFKBIA RELA TOPORS NFKB2 SLC34A1 TNKS2 TNKS SLC17A5 MAP3K7 GGCX BGLAP PROZ GAS6 MRPS17 MRPS15 GFM1 MRPS16 MRPS14 MRPS11 MRPS12 MRPL38 CFP MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 FUCA1 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPS18B MRPL49 MRPS18A MRPS2 MRPS21 MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 RAB3D MRPL44 TUFM MRPS18C RAB44 MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPS34 RAB37 MRPL19 MRPL16 MRPS31 MRPL17 RAB4B MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 FCGR3B MRPL55 MRPL11 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 RAB24 MRPL22 MRPL30 ANPEP ARSA ELOB ELOC COMMD9 ARSB BST1 CTSH MME COMMD3 TTR CDC25A N6AMT1 APEH TRMT112 NUP107 NUP188 SRP14 SLC34A2 NUP210 NUP93 VCP POM121 NUP205 ADA2 SEL1L AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 ABCA3 NUP153 CP ATP6AP2 PLAUR RNF185 NUP62 NDC1 NUP133 NUP50 NUP54 DERL1 DERL2 RNF5 UBE2B OS9 DTL NUP42 RAD18 NUP43 RAE1 RANBP2 NUP35 SEC61A2 NUP37 SEC61A1 SEC61G SEC61B CSF2RB CSF2RA TDG CDC20 ACE2 SHC1 CTBP1 ST6GALNAC1 KLK13 CMAS MPI GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ST6GAL2 ALG5 RENBP DPM1 DPM2 DPM3 MVD ST6GALNAC5 GNE ST6GALNAC6 UAP1 NPL FUOM NEU2 NEU3 NEU4 GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 ST3GAL6 CTSA PMM1 ST8SIA1 ST8SIA2 GFPT2 GFPT1 PMM2 ST8SIA3 SRD5A3 DOLK NAGK FCSK GLB1 DOLPP1 EPAS1 HIF1A SOCS3 PRL GH1 NOD1 NOD2 RIPK2 TRAF6 UBE2N TAB1 TFAP2B TFAP2C CGB8 YY1 TPST2 TPST1 STX1A SERP1 CEBPB CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 PEX2 ATF3 ATF4 FBXL7 PEX10 PEX12 PEX13 PEX14 FBXL18 PML NRIP1 PPARGC1A USP4 USP2 APH1A APH1B OTUD7B PSENEN BIRC2 BIRC3 USP21 OTULIN BLM BARD1 BRCA1 ALPI ING2 WRN RPA1 FUT3 HIF3A B4GALNT2 CUL2 VHL TUBB8 TUBB8B DNMT1 SUDS3 DNMT3B SUZ12 MDC1 TXN AARS1 HARS1 YARS1 WARS1 GARS1 NARS1 PPA1 DDB2 FARSA PCNA CARS1 TARS1 FARSB VARS1 NPM1 UCN IGFBP3 HYOU1 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B PTEN RABGGTB RABGGTA BIRC5 GNAT3 DCAF13 CRHR2 B3GLCT ADAMTS12 ADAMTS10 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS19 ADAMTS17 B4GAT1 SFTA3 US11 CETN2 CCP110 ACTR1A TUBA1A GCG BTRC MUC5AC ADAMTS20 THSD7B C1GALT1C1 RAB8A THSD7A ALG8 ALG9 SKP1 ALG6 ALG3 ALG1 FBXW11 MUC12 IAPP MUC15 SFTPB CSNK1D SFTPD CALCA MUC3A MUC3B DYNLL1 MUC16 MUC17 TUBA4A MUC19 MUC20 MUC21 UBA52 MUC5B NLRP3 ADAMTSL1 DYNC1I2 ADAMTSL5 ADAMTSL4 DCTN2 ADAMTSL3 ADAMTSL2 DCTN3 CUL1 AURKA LARGE1 IL6 ADAMTS2 ADAMTS3 ADAMTS6 UBB ADAMTS7 THSD1 THSD4 UBC RPS27A DYNC1H1 TUBB4B GIP TUBB4A ALG14 ALG13 CDK1 ALG12 ALG11 PIAS4 HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR3C2 PIAS1 NR4A2 NR5A1 AR RXRA SUMO1 B2M HLA-A SUMO3 POMGNT1 SUMO2 RARA RFT1 PPARG PGR PPARA THBS2 MUC1 MUC2 MUC7 MUC4 MUC6 USP13 RNF146 OTUD3 UBE2C UBE2E1 UBE2D1 UBE2S SPON2 SPON1 PSMD8 PSMD9 PSMD6 PSMD7 SBSPON PSMD4 PSMD5 DPAGT1 PSMD2 PSMD3 PSMD1 SSPOP PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 GALNT3 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 OTUB2 PSMB6 OTUD7A PSMB7 VCPIP1 PSMB4 ZRANB1 PSMB5 YOD1 PSMB2 PSMB3 APC PSMB1 RNF128 TNIP1 PSMF1 TNIP2 TNIP3 PSMB8 OTUB1 PSMB9 SEM1 SEMA5B PSMC5 PSMC6 PSMC3 PSMC4 CUL5 PSMC1 MPDU1 PSMC2 SFTPA1 MUCL1 C1GALT1 GALNT12 UBE2Z UBE2L3 UBE2Q2 RNF152 RIPK1 SHPRH TRAF2 UBE2E3 RNF40 RNF144A CDC34 UBE2R2 APP SELENOS WAC UBA6 BCL10 UBE2J2 HLTF TMEM129 UBE2H UBE2G1 UBE2A UBE2G2 UBE2W UBE2T RNF181 UBA1 LHB ACADVL C3 PENK CGA FFAR4 FFAR1 FSHB F2 CUL7 FKBP14 CXXC1 MYDGF EXTL2 EXTL1 TATDN2 DNAJB9 SSR1 GRP EXTL3 TSPYL2 KLHDC3 ZBTB17 DDX11 WIPI1 PDIA5 YIF1A CTDSP2 DNAJB11 SRPRA SRPRB HDGF TPP1 ACHE BCHE MBOAT4 IGF1 PLA2G7 IGF2 AGT LRR1 CCNF DCAF8 SAA1 DCAF5 VDAC3 DCAF4 VDAC2 DCAF6 VDAC1 FBXO7 ATP6V0D1 FBXO9 WSB1 WSB2 FBXO2 OBSL1 DCUN1D5 DCUN1D3 DCUN1D4 DCUN1D1 DCUN1D2 COMMD8 PUM2 FBXL8 FBXL4 DDA1 ANKRD9 UBXN7 COMMD2 COMMD1 COMMD6 COMMD7 COMMD4 COMMD5 GAN KLHL2 KLHL3 SPSB3 KLHL9 SPSB2 SPSB1 KBTBD6 KLHL5 CCDC8 KBTBD8 SPSB4 ADRB2 FBXO27 FBXO21 FBXO22 FBXW12 KNG1 CISH FBXW8 FBXO17 FBXO15 LMO7 FBXO10 FBXO11 ANO8 KLHL41 KCTD7 KLHL42 CUL9 KLHL11 KLHL13 FBXO44 FBXO41 SOCS2 FBXO40 BTBD1 UBD NAE1 SOCS6 SOCS5 WDTC1 UBE2F KLHL25 ZBTB16 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 SLC30A7 KLHL20 CCDC22 SLC30A6 KBTBD13 SLC30A8 COMMD10 TULP4 CXCL8 ASB13 ASB14 SLC30A5 ASB11 RNF7 ASB12 ASB17 ASB18 FBXL22 FBXL21P ASB15 ASB16 FBXL20 DCAF16 DCAF17 ASB10 FEM1C DCAF10 DCAF11 FEM1A FEM1B FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 TSHB FBXL12 NEURL2 ASB8 ASB9 ASB6 ASB7 ASB4 ASB5 ADRA2C ASB2 ASB3 ASB1 ADRA2A ADORA2A ADORA2B P2RY2 CCL2 ADD1 CAND1 POMC RUVBL1 NFRKB PARP1 ACTR5 ACTL6A RAD23A ACTR8 ADAM10 HSPG2 RAD23B UBE2V2 INO80C INO80B INO80E INO80D XPC TFPT KLK2 MCRS1 ADAMTS16 INO80 NCSTN ADAMTS18 LAMC1 ADAMTS4 ADAMTS5 ADAMTS1 CPA3 ENPEP CPB1 ACE GZMH CTSG TIMP1 AOPEP ADAMTS8 REN RAB2A ADAMTS9 CTSD MMP1 MMP2 PCSK2 ERO1B MYRIP CLTRN INHBB INHBA INHBC INHBE CPE INHA FURIN PLG SPP1 CMA1 LAMB1 PRKDC FGF23 LTF TRRAP KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 USP17L30 HCFC1 RNF123 BRCC3 SNX3 RHOT1 RCE1 SIAH2 TADA2B H2AC21 BAP1 H2AW WDR48 IDE BABAM1 BABAM2 UCHL1 UIMC1 UFD1 LYZ TOMM70 JOSD2 UCHL3 JOSD1 BPIFB2 UCHL5 PTRH2 PRKN WDR20 SEMG1 USP17L21 USP17L20 USP17L22 HSPA8 STAMBPL1 USP17L15 MBD5 USP17L18 MBD6 USP17L17 USP17L19 USP17L10 USP17L2 USP17L12 USP17L3 USP17L11 USP17L1 USP17L13 KDM1B TOMM20 ATXN3L USP8 USP5 USP3 MUL1 SPTAN1 H2AC1 FKBP8 STAMBP SPTBN1 FOXO4 ATXN3 ATXN7 CLSPN USP9X SMAD1 SMAD7 TADA3 OGT USP37 USP33 USP34 MYSM1 POLB SENP8 USP30 USP47 USP48 USP49 USP42 USP44 AXIN1 AXIN2 H2BC18 BECN1 USP14 USP15 USP16 USP10 ABRAXAS1 KHSRP USP12 FOXK2 FOXK1 NUP214 ABRAXAS2 DIS3 MAT2B USP18 USP19 USP24 USP25 USP26 PABPC1 USP20 DCP2 USP22 ADRM1 USP28 ASXL1 PARN ASXL2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 EIF4G1 CCNA2 CCNA1 CCNE2 CCNE1 TP53 COP1 NFYA CDKN2A NFYB MDM2 NFYC MDM4 RBX1 TOP2A STS VCAN SUMF2 SUMF1 IL33 RNF20 CCT2 CUL3 GPS1 COPS4 COPS2 ARSL HNRNPC ARSJ ARSK CCT7 ARSH ARSI ARSF ARSG ARSD KBTBD7 TGFB1 TGFBR1 RHOA TGFBR2 PDE3B SIGNALLING%REACTOME%R-HSA-165160.3 PDE3B signalling PDE3B AKT2 HDL REMODELING%REACTOME DATABASE ID RELEASE 76%8964058 HDL remodeling APOA1 LCAT APOC2 ALB APOE LIPG ABCG1 CETP APOC3 DEFECTIVE BTD CAUSES BIOTIDINASE DEFICIENCY%REACTOME DATABASE ID RELEASE 76%3371598 Defective BTD causes biotidinase deficiency BTD RRNA PROCESSING%REACTOME%R-HSA-72312.3 rRNA processing RCL1 TBL3 MPHOSPH10 NOL11 NOP10 HSD17B10 RPL4 RPL5 RPL30 NSUN4 RPL3 MTERF4 RPL32 TFB1M RPL31 MRM1 RPL34 MRM2 RPLP1 MRM3 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 CSNK1D RPS4X RPS15 CSNK1E RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 SNU13 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 MTREX RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 TRMT112 DDX21 RPP30 RPP38 RPP21 RPP25 RPP14 RPP40 XRN2 NOP56 RRP1 LAS1L DIS3 NOP58 RIOK2 RIOK1 TEX10 GNL3 NIP7 EXOSC10 RIOK3 EXOSC7 WDR18 EXOSC6 WDR12 EXOSC5 BYSL EXOSC4 TSR1 EXOSC9 FTSJ3 EXOSC8 EBNA1BP2 EXOSC3 NCL EXOSC2 ISG20L2 EXOSC1 NOB1 C1D LTV1 ERI1 NOL12 NOL9 PES1 BOP1 MPHOSPH6 RBM28 SENP3 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DIEXF TRMT10C DKC1 PRORP NHP2 TSR3 ELAC2 HEATR1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 GAR1 RRP36 UTP20 DCAF13 UTP6 NOP2 NOP14 UTP4 PNO1 KRR1 UTP3 MITOCHONDRIAL CALCIUM ION TRANSPORT%REACTOME DATABASE ID RELEASE 76%8949215 Mitochondrial calcium ion transport STOML2 MCUB VDAC3 SPG7 VDAC2 PHB VDAC1 MAIP1 PHB2 LETM1 PARL AKAP1 AFG3L2 SMDT1 YME1L1 PMPCB PMPCA MICU3 MICU2 MICU1 MCU SLC8A3 SLC8B1 GP1B-IX-V ACTIVATION SIGNALLING%REACTOME DATABASE ID RELEASE 76%430116 GP1b-IX-V activation signalling RAF1 GP5 PIK3R1 YWHAZ GP9 VWF GP1BB FLNA GP1BA TRANSPORT OF CONNEXINS ALONG THE SECRETORY PATHWAY%REACTOME%R-HSA-190827.2 Transport of connexins along the secretory pathway GJB2 GJB1 GJA1 SIGNALING BY APC MUTANTS%REACTOME DATABASE ID RELEASE 76%4839744 Signaling by APC mutants PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 NEIL3-MEDIATED RESOLUTION OF ICLS%REACTOME%R-HSA-9636003.1 NEIL3-mediated resolution of ICLs NEIL3 DEFECTIVE CHSY1 CAUSES TPBS%REACTOME%R-HSA-3595177.1 Defective CHSY1 causes TPBS CSPG5 CSPG4 BCAN NCAN DCN BGN VCAN CHSY1 G2 PHASE%REACTOME DATABASE ID RELEASE 76%68911 G2 Phase CCNA1 CDK2 E2F1 E2F3 CCNA2 RNA POL II CTD PHOSPHORYLATION AND INTERACTION WITH CE%REACTOME%R-HSA-77075.2 RNA Pol II CTD phosphorylation and interaction with CE CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 GLUCAGON-TYPE LIGAND RECEPTORS%REACTOME%R-HSA-420092.1 Glucagon-type ligand receptors ADCYAP1 ADCYAP1R1 GNG3 VIP GNG2 GNG5 GNG4 GNG7 GNG8 CYSLTR2 VIPR1 VIPR2 SCT GNG10 GNAS GNG12 GLP1R GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 SCTR GNB5 GCG GHRH GNGT1 GLP2R GIP GNGT2 GIPR GHRHR DEFECTIVE NTHL1 SUBSTRATE BINDING%REACTOME%R-HSA-9630222.1 Defective NTHL1 substrate binding NTHL1 PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC%REACTOME DATABASE ID RELEASE 76%389957 Prefoldin mediated transfer of substrate to CCT TriC PFDN5 PFDN6 CCT6B TUBB6 TUBB3 TUBB1 TUBA3D TUBA3C CCT2 TUBA4A CCT8 CCT5 CCT4 CCT7 ACTB CCT6A TUBA1A TUBA1C TUBB4B TUBB4A CCT3 VBP1 TUBB2B TUBB2A TCP1 PFDN1 PFDN2 PFDN4 MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES%REACTOME%R-HSA-450282.1 MAPK targets Nuclear events mediated by MAP kinases PPP2R1B FOS PPP2R5D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DUSP4 ATF1 DUSP3 VRK3 PPP2CA DUSP6 PPP2CB DUSP7 MAPK7 JUN MAPKAPK2 MAPK9 MAPK10 CREB1 PPP2R1A MAPK14 MAPK11 ATF2 MAPK8 ACYL CHAIN REMODELLING OF PC%REACTOME DATABASE ID RELEASE 76%1482788 Acyl chain remodelling of PC PLAAT3 PLA2G4A PLA2G6 PNPLA8 PLA2G2A LPCAT3 LPCAT2 PLA2G1B PLA2G5 PLB1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G4D PLA2G2E PLA2G4E PLA2G4B MBOAT2 PLA2G4C PLBD1 LPCAT4 PLA2G10 PLA2R1 PLA2G3 LPCAT1 TMEM86B SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24-HYDROXYCHOLESTEROL%REACTOME%R-HSA-193775.1 Synthesis of bile acids and bile salts via 24-hydroxycholesterol HSD3B7 PTGIS AKR1C1 AKR1C3 AKR1C2 AKR1C4 CYP8B1 CYP27A1 CYP39A1 AMACR AKR1D1 SLC27A2 CYP46A1 SLC27A5 RECEPTOR MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 76%8934903 Receptor Mediated Mitophagy CSNK2A1 ATG5 ATG12 MAP1LC3A CSNK2A2 FUNDC1 CSNK2B MAP1LC3B ULK1 GLUTATHIONE CONJUGATION%REACTOME%R-HSA-156590.2 Glutathione conjugation GSTA1 GGT3P MGST3 MGST1 MGST2 CNDP2 HPGDS GSTT2B GSTT2 GSTM4 GSTT1 GSTM3 GSTZ1 GSTM2 GSTM1 ESD GGT5 GGT7 GGT6 GSTM5 GGCT GSTO2 GCLC GSTO1 AKR1A1 GCLM GSTP1 OPLAH CHAC2 GSS CHAC1 GSTK1 GGT1 GSTA5 GSTA4 GSTA3 GSTA2 ACTIVATION OF RRNA EXPRESSION BY ERCC6 (CSB) AND EHMT2 (G9A)%REACTOME DATABASE ID RELEASE 76%427389 Activation of rRNA Expression by ERCC6 (CSB) and EHMT2 (G9a) HDAC2 HDAC1 H3C15 MTA1 RBBP4 H2BS1 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 GATAD2B H2AX GATAD2A EHMT2 H2AB1 H2AC20 H2AC19 ERCC6 CHD4 CHD3 TTF1 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 CAM-PDE 1 ACTIVATION%REACTOME%R-HSA-111957.1 Cam-PDE 1 activation PDE1C PDE1B PDE1A CALM1 PARADOXICAL ACTIVATION OF RAF SIGNALING BY KINASE INACTIVE BRAF%REACTOME DATABASE ID RELEASE 76%6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF BRAP FN1 BRAF FGB FGA VWF KRAS FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CAMK2B PHB CSK CAMK2D HRAS CAMK2A MARK3 MAP3K11 CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 JAK2 KSR2 CALM1 SRC NEGATIVE REGULATION OF FGFR3 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654732 Negative regulation of FGFR3 signaling PPP2CA PPP2CB UBB BRAF UBC FGF1 RPS27A FGF2 FGF4 PTPN11 MKNK1 FGF9 SPRY2 FGF20 PPP2R1A FGF23 UBA52 FRS2 FGF16 MAPK1 FGF18 CBL MAPK3 ENERGY DEPENDENT REGULATION OF MTOR BY LKB1-AMPK%REACTOME%R-HSA-380972.1 Energy dependent regulation of mTOR by LKB1-AMPK PRKAA1 CAB39 CAB39L RPTOR STK11 MLST8 SLC38A9 STRADA STRADB TSC2 TSC1 MTOR PPM1A RRAGA PRKAB2 RRAGC PRKAA2 RHEB PRKAG1 RRAGB PRKAG2 RRAGD LAMTOR2 PRKAB1 LAMTOR1 PRKAG3 LAMTOR4 LAMTOR3 LAMTOR5 EGFR INTERACTS WITH PHOSPHOLIPASE C-GAMMA%REACTOME DATABASE ID RELEASE 76%212718 EGFR interacts with phospholipase C-gamma HBEGF AREG TGFA EGFR EREG BTC PLCG1 EGF EPGN ATF6 (ATF6-ALPHA) ACTIVATES CHAPERONES%REACTOME%R-HSA-381033.2 ATF6 (ATF6-alpha) activates chaperones HSP90B1 ATF6 HSPA5 NFYA DDIT3 MBTPS2 NFYB NFYC CALR ATF4 MBTPS1 TANDEM PORE DOMAIN HALOTHANE-INHIBITED K+ CHANNEL (THIK)%REACTOME%R-HSA-1299287.2 Tandem pore domain halothane-inhibited K+ channel (THIK) KCNK13 FLT3 SIGNALING%REACTOME%R-HSA-9607240.6 FLT3 Signaling FOXO3 SOCS6 BCL2L11 ABL2 PIK3CA FLT3 SH2B3 SOS1 GRAP2 LCK SYK UBA52 FYN PTPRJ HCK AKT2 AKT1 UBB STAT5A CSK STAT5B HRAS UBC RPS27A NRAS PTPN11 PIK3R1 SLA FLT3LG SLA2 GRB10 GAB2 CDKN1B SOCS2 CBL AKT3 SIGNALING BY HEDGEHOG%REACTOME%R-HSA-5358351.3 Signaling by Hedgehog DERL2 ERLEC1 SHH OS9 HHAT DHH IHH SYVN1 ARRB1 ARRB2 BTRC PRKACA SKP1 OFD1 GSK3B UBA52 CUL1 UBB DISP2 PRKAR2B SCUBE2 UBC RPS27A HHIP ADAM17 ULK3 DZIP1 EFCAB7 BOC IQCE EVC GAS1 SPOPL GAS8 SPOP GPC5 EVC2 SMURF2 IFT172 PRKACG PRKACB DYNC2H1 RPGRIP1L RBX1 IFT88 ADCY9 PRKAR1B SMO PRKAR1A GPR161 INTU KIF3A TTC21B PRKAR2A PTCH1 IFT122 FUZ ADCY10 GNAS MKS1 GLI1 GLI3 GLI2 IFT52 SUFU IFT57 IFT140 KIF7 WDR35 NUMB ADCY4 TULP3 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 CDON CSNK1A1 WDR19 ITCH PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 VCP PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 SEL1L PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 P4HB PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SMURF1 GRK2 NOTUM CDC73 CDC42 GTPASE CYCLE%REACTOME%R-HSA-9013148.1 CDC42 GTPase cycle WDR91 FARP1 STARD8 WDR81 GNA13 DAAM1 IQGAP3 TRIO TFRC ARHGDIG STARD13 ARHGDIA JUP MCF2L CDC42SE2 SNAP23 VAV3 PAK3 ARHGAP9 PLEKHG3 ARHGAP1 ARHGEF16 ARHGAP39 ARHGAP4 ARHGAP5 ARHGAP35 ARHGEF5 DOCK10 ARHGEF26 PREX1 GMIP SYDE1 PLD1 WAS ARHGAP42 IQGAP2 CDC42EP5 DOCK11 OPHN1 CDC42EP3 ARHGDIB CDC42EP2 MAP3K11 LBR TMPO ARAP2 RAB7A CHN1 ARAP3 CYBA MYO9B WASL PIK3R1 VAV2 BCR IQGAP1 TIAM1 ARFGAP3 SHKBP1 CDC42EP1 CDC42 PAK1 ARFGAP2 VAMP3 PAK6 NOXO1 ARHGAP17 PIK3R2 GIT1 GIT2 ARHGAP21 ABR FAM13B RACGAP1 VANGL1 DEPDC1B GOLGA8R SRGAP2 ARHGEF7 YKT6 PAK4 CAV1 STOM MCF2 BAIAP2 ARHGAP26 ARHGAP11B ARHGAP32 DOCK6 TAGAP DIAPH3 PLEKHG4 PLEKHG1 NOXA1 NOX1 DOCK9 SRGAP3 DOCK8 SRGAP1 DOCK7 SCRIB CDC42BPB CDC42BPA KTN1 CPNE8 SPATA13 ITSN1 FNBP1L SH3PXD2A PLEKHG4B FNBP1 DLC1 RASGRF2 ARHGAP44 ARHGAP40 RALBP1 KCTD3 ARHGAP45 STEAP3 ARHGEF25 ARHGAP22 ARHGAP20 PREX2 NGEF ARHGAP29 ARHGAP27 ARHGAP24 PAK5 ARHGAP33 ARHGAP31 ARHGAP30 ECT2 DNMBP FMNL3 FMNL1 FMNL2 ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF19 ARHGAP10 ARHGEF9 ARHGEF4 ARHGEF6 FGD1 FGD2 FGD3 FGD4 WIPF1 WIPF2 WIPF3 PAK2 LAMTOR1 ARAP1 CDC42EP4 DEF6 PARD6A TALDO1 DEFICIENCY: FAILED CONVERSION OF FRU(6)P, E4P TO SH7P, GA3P%REACTOME DATABASE ID RELEASE 76%6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P TALDO1 LEADING STRAND SYNTHESIS%REACTOME%R-HSA-69109.3 Leading Strand Synthesis POLD2 RFC5 RFC3 RFC4 RFC2 PRIM2 PRIM1 RFC1 POLA1 POLA2 PCNA POLD3 POLD4 POLD1 SIGNALING BY KIT IN DISEASE%REACTOME DATABASE ID RELEASE 76%9669938 Signaling by KIT in disease STAT5A STAT5B STAT1 HRAS PIK3CA SOS1 NRAS LCK PIK3R1 JAK2 PIK3R3 KIT FYN STAT3 PIK3R2 LYN YES1 GLUCURONIDATION%REACTOME DATABASE ID RELEASE 76%156588 Glucuronidation UGT1A10 UGP2 UGT1A5 UGT1A4 ABHD10 UGT1A3 UGT1A9 UGT2B10 UGT2B11 UGT1A8 UGT2B15 UGT1A7 UGT1A6 UGT2B17 UGT3A2 UGT3A1 UGDH UGT2A3 UGT2A2 UGT2A1 UGT1A1 SLC35D1 UGT2B4 UGT2B7 UGT2B28 SIGNALING BY GPCR%REACTOME DATABASE ID RELEASE 76%372790 Signaling by GPCR PLCB3 GPR15 PLCB1 PRKCB PLCB2 FZD8 PPP3R1 FZD7 SHH WNT11 DHH GPR27 GPR25 IHH FZD3 GPR20 FZD5 ADM FZD6 PTH1R GPR32 PTH2R MAPK1 RAMP2 RAMP3 MAPK3 GPR45 PTH GNAI3 PRKX GNAI1 GNAI2 WNT3A GPR150 SCTR PPP2R1A GCG GHRH ADM2 RAMP1 PRKACA IAPP PRKCG GNAZ CALCA CALCB CALCRL GPR83 WNT1 GPR84 WNT4 FZD1 CALCR CDK5 GLP1R PRKAR2B GLP2R GIP CRH PTH2 PTHLH VIP CAMKK1 RASGRF2 CAMKK2 NBEA ADGRE5 ADGRE3 PRKCE PPP3CC RASGRP2 RASGRP1 GNAL RGS9 RGS6 RGS7 NPFFR2 APP OXTR MCF2L NPFFR1 VAV3 RXFP4 RRH ARHGEF16 HTR4 GRPR VAV1 RXFP1 RXFP2 GNG10 RXFP3 ARHGEF5 EDNRA ARHGEF26 HTR6 EDNRB HTR7 GNG12 C3AR1 KALRN GNG11 OXER1 GNG13 PROK2 PROK1 GNB2 PTGDR GNAQ CMKLR1 GNB1 UTS2R TAAR8 GNB4 TAAR9 TAAR6 GNB3 NPFF TAAR5 TAAR2 GNB5 GPR37L1 PDYN TAAR1 TRHR GNGT1 UTS2B KEL AGTR1 GNGT2 AGTR2 PTGFR LHB LPAR1 FPR1 LPAR2 LPAR3 FPR3 LPAR4 FPR2 C3 NLN MC2R C5 GALR3 GALR2 GNA14 GALR1 NPBWR1 PENK GNG3 NPBWR2 GNA15 PPY HCRT GNG2 CGA CCR10 GNG5 NTSR1 GNG4 NTSR2 GNG7 CCR1 GNA11 GPR17 GNG8 NMB XCR1 PPBP NMBR MC1R LPAR5 LPAR6 RGS11 NMS GPR183 PNOC NMU GNRH2 GNRH1 GPR18 PTGDR2 QRFP PLEKHG5 CX3CL1 MLN BRS3 MC4R GPR132 CCKAR OPN1LW CCR9 FFAR4 GNRHR CCR8 FFAR3 CCR7 FFAR2 FFAR1 CCR6 CCR5 CCR4 PPP1CA CCR3 OXGR1 CCR2 GPR39 ITSN1 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B GPR35 AKT3 FSHB TACR2 GPBAR1 GPR31 MGLL TACR3 AVPR1A TACR1 F2 MC3R GAL PIK3CA ADRB3 CCKBR OPN1MW SOS1 FSHR AVP RGR PTGER4 NPSR1 OPRD1 CCL13 NPB CCL11 PLPPR1 PLPPR2 GRP PTGER1 PLPPR3 PTGER2 PLPPR4 PTAFR PTGER3 FZD4 PLPPR5 ARHGEF25 CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R RHO CCL19 PRLH CCL17 GPHA2 CCL16 CCL25 P2RY12 P2RY13 P2RY10 CCL22 P2RY11 CCL21 CCL20 P2RY14 GPR55 GPR4 AGT GPR143 XK MT-RNR2 MC5R SAA1 F2RL1 CCL28 CCL27 F2RL2 PF4 F2RL3 GPHB5 CHRM2 CHRM3 CHRM1 GPR68 CHRM4 GPR65 NPY2R CHRM5 PMCH CXCL13 HBEGF CXCL16 CYSLTR1 CYSLTR2 ADORA3 CCRL2 EGFR ADORA1 AKT2 GHSR LHCGR F2R NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 CCL3L3 C5AR2 C5AR1 ADRB1 ADRB2 NTS MCHR1 MCHR2 KNG1 HCAR2 HCAR3 TAAR3P HRH1 HCAR1 HRH3 TBXA2R HRH2 PSAP HRH4 TAC3 DRD1 DRD2 TAC1 DRD3 DRD4 DRD5 OPN4 OPN3 HTR1E HTR1F HTR1D HTR1A HTR1B OPN5 CXCL10 PYY CXCL11 KPNA2 CXCL12 RLN2 RLN3 NMUR2 NMUR1 GNA13 CXCL6 CXCL9 GNAT1 CXCL8 GAST MLNR PLCB4 HTR2B TRIO HTR2C RGSL1 PPP1R1B OXT ECE1 PDE3A ADRA1D CCL4L2 RGS4 CXCL1 HTR2A RGS5 ECE2 RPS6KA3 RGS2 TRH RGS3 RPS6KA2 RGS1 CXCL3 ADRA1B RPS6KA1 PDE8B RGS8 CXCL2 ADRA1A PDE8A PCP2 CXCL5 PREX1 GRK5 LTB4R GRK6 HEBP1 ARRB1 GPSM1 GPER1 ARRB2 GPSM2 BDKRB2 PRLHR PDE4B PDE4A BDKRB1 INSL3 GPSM3 QRFPR PDE4D INSL5 PDE4C TSHB RGS18 PTGIR RGS17 NPY5R RGS19 GNRHR2 RGS14 AVPR2 RGS13 OPRM1 RGS16 SSTR1 RGS21 SSTR2 RGS20 ADRA2C RGS22 SSTR3 RGS10 ADRA2B VAV2 RGS12 SSTR4 PDE7B ADRA2A TIAM1 PDE7A SSTR5 CORT ADORA2A ADORA2B XCL2 XCL1 CX3CR1 NPY4R PIK3R2 OPRL1 P2RY6 CCL7 CNR2 P2RY4 ABR CNR1 CCL5 P2RY2 CCL4 P2RY1 CCL3 S1PR1 CCL2 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HTR5A HCRTR2 MCF2 TSHR APLN HCRTR1 KISS1 POMC OPN1SW SST ACKR4 ACKR3 ACKR2 ACKR1 SRC ARHGEF40 TIAM2 OBSCN NGEF MMP3 ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L AKAP13 ARHGEF11 ARHGEF10 PLEKHG2 CD55 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 PDE3B WNT10B WNT5A GRK3 GRK2 PPP2R1B TRPC7 TRPC6 TRPC3 PLA2G4A PPP2R5D PDE1B PDE1A ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PDE11A PDE2A PDPK1 PIK3R1 PDE10A CDC42 PAK1 CALM1 ADCYAP1 ADCYAP1R1 ARHGEF7 AKT1 PRKCD PRKCA MAPK7 CAMK2B CAMK2D CAMK2A CAMK2G DGKG DGKE DAGLA DGKD CREB1 DGKB DGKA CAMK4 ABHD6 ABHD12 PRKCH DGKZ DGKQ PRKCQ DAGLB DGKK DGKI DGKH PRKACG PRKACB ADCY9 PRKAR1B FZD10 SMO CRHBP PRKAR1A WNT10A BTK RHOC FZD9 RHOB UCN3 GNA12 UCN2 PLXNB1 PRKAR2A WNT9B WNT9A PTCH1 WNT8A WNT8B WNT7B WNT7A GNAS WNT6 WNT2 WNT3 PTCH2 UCN WNT2B ADGRE1 ADGRE2 WNT16 PDE1C PIK3R6 ADCY4 PIK3CG PIK3R5 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 TAS2R60 TAS2R7 TAS2R9 TAS2R40 TAS2R8 TAS2R41 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM1 GRM3 GPRC6A GRM2 GRM5 GRM4 ROCK1 GRM7 ROCK2 GRM6 GRM8 TAS1R2 TAS2R1 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 VIPR1 GABBR2 VIPR2 CASR AHCYL1 GABBR1 SCT TAS2R30 TAS2R31 TAS2R10 TAS2R13 TAS2R14 TAS2R16 GPR176 TAS2R38 TAS2R39 GNAT3 TAS2R19 HRAS NRAS PIK3R3 ARHGEF18 GIPR RHOA CRHR1 CRHR2 PPP3CA GHRHR PPP3CB GNAT2 CENTROSOME MATURATION%REACTOME DATABASE ID RELEASE 76%380287 Centrosome maturation HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 CSNK1D HAUS6 HAUS5 TUBGCP5 CSNK1E TUBGCP6 TUBG1 TUBGCP3 DYNLL1 TUBGCP4 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 NME7 SDCCAG8 PAFAH1B1 CDK11A DYNC1I2 DCTN2 SSNA1 CDK11B DCTN3 MZT1 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 SYNTHESIS OF GDP-MANNOSE%REACTOME%R-HSA-446205.1 Synthesis of GDP-mannose MPI GMPPB PMM1 GMPPA PMM2 SENSORY PERCEPTION%REACTOME DATABASE ID RELEASE 76%9709957 Sensory Perception PDE6B PDE6A PDE6G CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 TPRN PLS1 TMC1 MYO7A TMC2 MYO3B RDH12 MYO3A KCNQ4 FSCN2 EZR SLC24A1 PCDH15 USH1C TWF2 TWF1 ESPNL EPB41L1 EPB41L3 CDH23 OTOG XIRP2 EPS8L2 MPP1 GRXCR1 GRXCR2 GSN WHRN RDX LHFPL5 MSN OTOGL TMIE USH1G MYO15A STRC SLC26A5 RLBP1 CACNB2 SNAP25 AWAT2 CAPZB DNAJC5 OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR1F12 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 CAPZA1 OR11G2 CAPZA2 OR2L5 OR1J2 OR2L3 CASK OR1J1 OR4P4 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 LRP1 RETSAT OR7A2P OR1I1 PLB1 OR2K2 TTR OR6S1 APOM OR5M11 RDH11 OR5M10 LRAT OR2I1P OR10D3 BCO2 OR8B12 BCO1 OR14K1 RBP4 OR4N5 CLPS OR2J3 OR4N4 AKR1B10 RBP2 OR2J2 RBP1 OR2J1 CHRNA9 OR4N2 CHRNA10 LRP10 OR5P3 KCNN2 PNLIP OR5P2 LRP12 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 CACNA1D OR6Y1 OR52B2 OR52B6 OR9A1P OR1N2 APOA2 OR1N1 APOA1 OR5V1 APOA4 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR1F2P OR14A16 OR10G2 LPL OR1L8 OR10G4 OR1L6 OR10G3 OR1L4 OR1L3 APOE LDLR OR1L1 OR5T3 GPIHBP1 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 APOC3 OR10G7 OR10G9 GUCA1B GUCA1A GUCA1C APOC2 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 STRA6 NMT1 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 PPEF1 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 GNAL OR51S1 OR4A47 OR5B21 REEP1 OR1P1 REEP5 REEP4 NMT2 REEP3 REEP2 REEP6 NAPEPLD OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 CNGA1 OR56B1 OR2Y1 OR8D4 OR8D2 PCLO OR56B4 BSN CACNA2D2 OR8D1 OR7A17 SYP OR6C70 SYN1 OR6C76 CABP2 OR6C75 CABP1 LRRC52 OR6C74 OR13G1 OTOF OR14I1 OR10A7 OR56A5 OR7A5 GNG13 OR10A2 OR56A4 OR52Z1 ABCA4 OR10A4 GNB1 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 GNGT1 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 RCVRN OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 METAP1 METAP2 OR7G2 OR7G1 OR8I2 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5AL1 OR5D13 OR8H2 OR8H1 OR56B2P OR52M1 OR10V1 OR2AT4 OR4C12 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR6C2 OR5A1 OR4C15 OR6C1 OPN1LW OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 SDC4 OR52K2 SDC2 OR51I1 OR52K1 SDC3 RPE65 OR9G9 OR4D11 OR2A12 OR4D10 GPC1 OR2Z1 GPC3 OR6A2 GPC2 OR9G4 GPC5 OR7C2 GPC4 OR7C1 OR9G1 GPC6 OR2A14 OR5G3 OR4E2 OR4E1 RDH8 OR3A4P OR51Q1 OPN1MW OR4D9 OR5AP2 OR5B12 SDC1 OR4D6 OR10D4P AGRN OR4D5 OR5B17 OR4D2 OR2B8P OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR14A2 OR4C3 OR3A2 OR4A15 OR3A1 OR4A16 OR8K5 OR8K3 GUCY2D OR8K1 HSD17B6 GUCY2F OR4C45 OR5AN1 OR4C46 OR4B1 RHO OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2W6P SDR9C7 OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR52A4P OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR52P1P RGS9BP OR5AC2 VAMP2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR14L1P OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 GRK1 FNTB OR2AK2 GRK7 OR51B6 OR51B5 OR51B4 OR2B6 RAB3A OR4F6 OR2B3 OR4F5 OR5H6 OR2B2 OR10K2 OR4F4 OR10K1 OR4F3 OR5H2 OR5H1 FNTA OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 RTP2 OR52J3 RTP3 OR51H1 RTP1 OR8U9 OR1G1 OR8U8 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR52I2 OR51G1 GNAT1 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR6P1 OR10Q1 SAG OR2AP1 OR2B11 OR51F2 OR51F1 OR5M9 OR2G6 OR52H1 OR5M8 OR1E3 OR1E2 OR4K5 OR2G3 OR1E1 OR2G2 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 STX1A OR8S1 OR2T34 OR2T35 OR2T33 OR5AK3P OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR10J6P OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F15 LRP2 MYO1C OPN1SW CNGB1 HSPG2 CAMKMT KCNMA1 LRP8 KCNMB1 APOB MYH9 ATP2B1 CALM1 SPTAN1 SPTBN1 DHRS3 DHRS9 RDH10 RDH16 RDH5 PRKCA CYP4V2 PRKCQ RBP3 HSD17B1 AKR1C1 AKR1C3 AKR1C4 SLC17A8 INTERLEUKIN-37 SIGNALING%REACTOME DATABASE ID RELEASE 76%9008059 Interleukin-37 signaling IL37 PTPN20 SIGIRR PTPN23 PTPN14 IL18BP PTPN13 PTPN9 PTPN5 SMAD3 CASP1 PTPN2 PTPN12 IL18R1 PTPN11 TBK1 PTPN4 STAT3 PTPN7 PTPN6 PTPN18 PURINERGIC SIGNALING IN LEISHMANIASIS INFECTION%REACTOME%R-HSA-9660826.1 Purinergic signaling in leishmaniasis infection C3 GSDMD CASP1 SUGT1 IL18 NLRP3 IL1A IL1B CTSG C3AR1 NT5E RELA PSTPIP1 ENTPD1 NFKB2 ENTPD5 P2RX7 TXNIP P2RX4 PYCARD NFKB1 MEFV TXN HSP90AB1 HMOX1 INTEGRIN CELL SURFACE INTERACTIONS%REACTOME DATABASE ID RELEASE 76%216083 Integrin cell surface interactions JAM2 JAM3 COL4A3 FN1 COMP ITGA8 LUM IBSP COL9A1 COL9A3 COL9A2 COL18A1 ITGB1 AGRN ITGA11 PECAM1 ITGAE ITGB7 THBS1 ITGA3 ITGAD ITGA7 CD47 CD44 TNC SPP1 FGB FGA FGG ICAM1 ITGA2B FBN1 COL16A1 ITGAM KDR ITGB2 ICAM2 ICAM3 CDH1 ITGA10 BSG ITGAX ITGB3 VTN ITGAL ITGAV ITGA6 ITGA2 COL23A1 ICAM4 ITGA1 VCAM1 ICAM5 HSPG2 ITGA5 F11R ITGA4 ITGA9 ITGB8 ITGB6 COL4A2 COL13A1 ITGB5 COL4A1 COL4A4 O-LINKED GLYCOSYLATION%REACTOME DATABASE ID RELEASE 76%5173105 O-linked glycosylation B3GNT9 B3GNT8 POMT2 POMT1 B3GNT6 B3GLCT B3GNT5 ADAMTS12 ADAMTS10 ADAMTS15 GALNT11 ADAMTS14 GALNT14 ADAMTS13 ST6GALNAC2 GALNT13 THBS1 GALNT16 ADAMTS19 GALNT15 ADAMTS17 GALNT18 GALNT17 GALNT10 B4GAT1 POMGNT2 ST3GAL4 ST3GAL1 POMK ST3GAL2 ST6GAL1 CFP ST6GALNAC3 ST6GALNAC4 MUC5AC ADAMTS20 THSD7B C1GALT1C1 THSD7A MUC12 MUC15 MUC3A MUC3B GALNT2 MUC16 MUC17 GALNT1 MUC19 SEMA5A MUC20 MUC21 MUC5B ADAMTSL1 ADAMTSL5 ADAMTSL4 ADAMTSL3 ADAMTSL2 LARGE1 MUC13 ADAMTS2 ADAMTS3 ADAMTS6 ADAMTS7 THSD1 THSD4 B3GALNT2 ADAMTS16 DAG1 ST3GAL3 ADAMTS18 POMGNT1 ADAMTS4 ADAMTS5 CHST4 THBS2 ADAMTS1 MUC1 MUC2 ADAMTS8 MUC7 MUC4 ADAMTS9 MUC6 POFUT2 B3GNT7 B3GNT4 B3GNT3 B3GNT2 B4GALT6 B4GALT5 B3GNTL1 SPON2 SPON1 SBSPON GALNT9 GALNT8 SSPOP GALNT7 GALNT6 GALNT5 GALNT4 GALNT3 GALNTL5 GALNTL6 GCNT1 GCNT3 GCNT4 GCNT7 A4GNT SEMA5B LARGE2 MUCL1 C1GALT1 GALNT12 UB-SPECIFIC PROCESSING PROTEASES%REACTOME%R-HSA-5689880.2 Ub-specific processing proteases TAB1 ARRB1 ARRB2 HGS CCP110 GATA3 UBA52 UBB RUVBL1 UBC RPS27A MYC CFTR SMAD4 SMAD3 SMURF2 AR TAF9B TAF10 USP4 USP2 H2AC19 H2AC14 H2BC21 H2BU1 USP13 RNF146 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 CYLD H2BC14 CDC25A KAT2A H2BC15 H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 H2BC9 PSME2 BIRC2 PSMD10 BIRC3 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 PSMD14 H2BC3 PSMD13 PSMA7 H2BC1 PSMB10 PSMA8 PSMB6 USP21 PSMB7 H2AC20 PSMB4 PSMB5 IFIH1 PSMB2 PSMB3 RNF128 PSMB1 PSMF1 PSMB8 DDX58 PSMB9 OTUB1 SEM1 IKBKG PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 PSMC2 STAM2 SMAD2 TRRAP KEAP1 H2AC17 H2AC12 USP17L4 USP17L5 USP17L8 USP17L30 RNF123 SNX3 RHOT1 RIPK1 RCE1 TRAF2 SIAH2 TADA2B H2AC21 H2AW WDR48 IDE UFD1 TOMM70 PTRH2 WDR20 USP17L21 USP17L20 USP17L22 USP17L15 USP17L18 USP17L17 USP17L19 USP17L10 USP17L2 USP17L12 USP17L3 USP17L11 USP17L1 USP17L13 TOMM20 USP8 USP5 USP3 MUL1 H2AC1 FKBP8 FOXO4 ATXN7 CLSPN USP9X SMAD1 USP11 SMAD7 TADA3 USP37 USP33 USP34 POLB USP30 USP47 USP48 USP49 SUDS3 USP42 USP44 AXIN1 AXIN2 H2BC18 BECN1 USP14 USP15 USP16 USP10 USP12 MAT2B USP18 USP19 CDC20 USP24 USP25 USP26 USP20 USP22 ADRM1 USP28 CCNA2 CCNA1 TP53 MDM2 MDM4 DDB2 SKP2 VDAC3 VDAC2 VDAC1 PTEN IL33 HIF1A NFKBIA ADRB2 TNKS2 TNKS TGFBR1 TRAF6 MAP3K7 PAUSING AND RECOVERY OF TAT-MEDIATED HIV ELONGATION%REACTOME%R-HSA-167238.2 Pausing and recovery of Tat-mediated HIV elongation CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 TCEA1 ADP SIGNALLING THROUGH P2Y PURINOCEPTOR 12%REACTOME DATABASE ID RELEASE 76%392170 ADP signalling through P2Y purinoceptor 12 GNG12 GNG11 GNAI1 GNAI2 GNG13 GNAT3 GNB2 GNB1 GNG3 GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 P2RY12 GNGT1 GNGT2 GNG10 GNAI3 SENESCENCE-ASSOCIATED SECRETORY PHENOTYPE (SASP)%REACTOME%R-HSA-2559582.2 Senescence-Associated Secretory Phenotype (SASP) CCNA1 CDKN2A CDK2 FOS CXCL8 MAPK1 RPS6KA3 IL1A RPS6KA2 RPS6KA1 MAPK3 H2AX EHMT2 H2AB1 H2AC19 H2AC14 FZR1 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 ANAPC15 CEBPB ANAPC16 ANAPC7 H2BC17 H2BC12 UBE2C UBE2E1 H2BC13 UBE2D1 H2BC14 ANAPC10 H2AJ ANAPC11 CDC23 H2BC15 UBE2S CDC26 NFKB1 CDC16 CDC27 H2BC11 ANAPC4 ANAPC5 ANAPC1 H3C15 H2BS1 H2AZ1 H2BC9 IGFBP7 UBA52 H2AZ2 H4C9 H2BC8 H2BC5 STAT3 H2BC3 H2BC1 IL6 H2AC20 UBB MAPK7 UBC JUN CDK6 RELA RPS27A CDK4 CDKN2D CDKN2C EHMT1 VENTX CDKN2B CDKN1A CDKN1B CCNA2 DEFECTIVE SLC7A7 CAUSES LYSINURIC PROTEIN INTOLERANCE (LPI)%REACTOME%R-HSA-5660862.1 Defective SLC7A7 causes lysinuric protein intolerance (LPI) SLC3A2 SLC7A7 DEFECTIVE SLC12A3 CAUSES GITELMAN SYNDROME (GS)%REACTOME%R-HSA-5619087.1 Defective SLC12A3 causes Gitelman syndrome (GS) SLC12A3 ABC TRANSPORTERS IN LIPID HOMEOSTASIS%REACTOME%R-HSA-1369062.3 ABC transporters in lipid homeostasis APOA1 ABCG8 PEX3 ABCG5 ABCA2 ABCA5 ABCA6 PEX19 ABCA9 ABCA7 ABCG1 ABCA10 ABCD1 ABCD2 ABCD3 ABCA12 ABCG4 ABCA3 SYNTHESIS OF BILE ACIDS AND BILE SALTS%REACTOME DATABASE ID RELEASE 76%192105 Synthesis of bile acids and bile salts RXRA AKR1D1 HSD17B4 CYP46A1 ABCB11 CYP7A1 OSBP OSBPL9 NCOA1 HSD3B7 ACOT8 OSBPL7 NCOA2 OSBPL6 PTGIS AKR1C1 OSBPL3 OSBPL2 AKR1C3 NR1H4 AKR1C2 AKR1C4 BAAT CYP7B1 CYP8B1 CYP27A1 CYP39A1 CH25H AMACR ACOX2 OSBPL1A SLC27A2 SLC27A5 EGR2 AND SOX10-MEDIATED INITIATION OF SCHWANN CELL MYELINATION%REACTOME DATABASE ID RELEASE 76%9619665 EGR2 and SOX10-mediated initiation of Schwann cell myelination HDAC2 NAB1 WWTR1 LAMB1 NAB2 DAG1 UTRN MBP ADGRV1 CYP51A1 EGR2 SREBF2 MPZ LAMC1 POU3F1 POU3F2 ADGRG6 LAMA2 HMGCR SOX10 MAG PRX TEAD1 DRP2 SCD5 YAP1 PMP22 SMARCA4 SYNTHESIS OF LEUKOTRIENES (LT) AND EOXINS (EX)%REACTOME DATABASE ID RELEASE 76%2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) CYP4F11 ALOX5 DPEP2 DPEP1 DPEP3 MAPKAPK2 CYP4A22 PTGR1 CYP4B1 LTA4H ALOX15 CYP4A11 CYP4F22 CYP4F2 LTC4S GGT5 CYP4F3 CYP4F8 GGT1 ABCC1 ALOX5AP DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH PMS2%REACTOME DATABASE ID RELEASE 76%5632987 Defective Mismatch Repair Associated With PMS2 PMS2 MLH1 MRNA 3'-END PROCESSING%REACTOME%R-HSA-72187.4 mRNA 3'-end processing CSTF2 PABPN1 PAPOLA CPSF1 CPSF4 EIF4A3 CASC3 MAGOH THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 DDX39A DDX39B ZC3H11A CPSF3 SARNP CPSF2 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB RNPS1 CSTF2T FIP1L1 CPSF7 SRRM1 CSTF3 NCBP1 NCBP2 CSTF1 SYMPK PCF11 WDR33 NUDT21 CLP1 RESISTANCE OF ERBB2 KD MUTANTS TO AEE788%REACTOME%R-HSA-9665250.1 Resistance of ERBB2 KD mutants to AEE788 HSP90AA1 CDC37 ERBB2 ERBIN P75 NTR RECEPTOR-MEDIATED SIGNALLING%REACTOME DATABASE ID RELEASE 76%193704 p75 NTR receptor-mediated signalling HDAC3 PRDM4 NGF GNA13 TRIO ARHGDIA MCF2L VAV3 ARHGEF16 VAV1 ARHGEF5 ARHGEF26 PREX1 KALRN YWHAE VAV2 TIAM1 NFKB1 MAPK8 ABR ARHGEF7 UBA52 MCF2 UBB PLEKHG5 UBC RPS27A RAC1 ADAM17 ITSN1 PSEN1 BCL2L11 NCSTN SOS1 RASGRF2 CASP3 ARHGEF40 PRKCI OMG TIAM2 MAG OBSCN SQSTM1 NGEF BEX3 MAGED1 PSEN2 RTN4 APH1A APH1B ECT2 ARHGEF33 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L AATF SMPD2 AKAP13 CASP2 HDAC2 MYD88 PSENEN HDAC1 ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 SORCS3 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 ITGB3BP ARHGEF6 FGD1 FGD2 FGD3 FGD4 LINGO1 BAD IKBKB NFKBIA RELA ARHGEF18 IRAK1 RIPK2 RHOA TRAF6 NGFR LATE ENDOSOMAL MICROAUTOPHAGY%REACTOME DATABASE ID RELEASE 76%9615710 Late endosomal microautophagy HDAC6 MVB12B PARK7 CFTR MVB12A VPS28 IFT88 CHMP2B CHMP2A UBA52 UBB HBB UBC HSPA8 UBAP1 RPS27A PCNT PLIN3 RNASE1 CHMP4C CHMP4B PLIN2 CHMP3 CHMP4A VPS37C CETN1 ARL13B VPS37D VPS37A CHMP6 VPS37B CHMP7 TSG101 ASSEMBLY OF ACTIVE LPL AND LIPC LIPASE COMPLEXES%REACTOME%R-HSA-8963889.2 Assembly of active LPL and LIPC lipase complexes APOA4 APOA5 APOC2 MBTPS2 ANGPTL8 ANGPTL3 ANGPTL4 LPL PCSK6 LMF2 LMF1 PCSK5 LIPC CREB3L3 FGF21 FURIN GPIHBP1 MBTPS1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 76%9694301 Maturation of replicase proteins rep NUCLEOTIDE-BINDING DOMAIN, LEUCINE RICH REPEAT CONTAINING RECEPTOR (NLR) SIGNALING PATHWAYS%REACTOME DATABASE ID RELEASE 76%168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways TAB1 UBE2V1 SUGT1 MAP2K6 CASP8 AAMP APP PANX1 CASP4 hly TNFAIP3 P2RX7 CYLD PYCARD ITCH NFKB1 HSP90AB1 fliC CASP2 fljB BCL2 prgJ BCL2L1 CASP1 NLRC4 BIRC2 BIRC3 NLRP1 NLRP3 AIM2 CARD9 MAPK12 MAPK13 IKBKB CHUK PSTPIP1 RELA CASP9 IKBKG NFKB2 TXNIP NOD1 NOD2 MAPK14 MAPK11 IRAK1 IRAK2 RIPK2 MEFV TXN TRAF6 UBE2N TAB3 MAP3K7 HMOX1 TAB2 SUNITINIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702632.1 sunitinib-resistant FLT3 mutants FLT3 AROMATIC AMINES CAN BE N-HYDROXYLATED OR N-DEALKYLATED BY CYP1A2%REACTOME%R-HSA-211957.2 Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 CYP1A2 SIGNALING BY FGFR2 FUSIONS%REACTOME DATABASE ID RELEASE 76%8853333 Signaling by FGFR2 fusions FGFR2 COX REACTIONS%REACTOME%R-HSA-140180.2 COX reactions PTGS1 SUPPRESSION OF AUTOPHAGY%REACTOME%R-HSA-9636569.1 Suppression of autophagy sapM RAB7A DUSP16 eis INFECTIOUS DISEASE%REACTOME%R-HSA-5663205.11 Infectious disease GSK3A ENO1 DUSP16 CORO1A eis lpdC esxH esxG RNF213 esxA Rv1410c PGK1 FYN ATP6V1H MAPK1 TRIM27 sapM Rv3655c ndkA MAPK3 KPNA1 Rv3364c ptpA secA2 NOS2 VPS33B PPE2 lprG lprM SFPQ HGS RAB5A KPNB1 Rv3654c RAB7A RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 RPL37 MAP2K1 RPS11 RPL39 MAP2K2 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 NCBP1 RPS8 NCBP2 RPS5 RPL23 RPL22 SNAP25 RPS6 RPL13A RPSA RPS3A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 MET RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 CTDP1 RPL17 ELL RPL19 CCNT1 RPL39L SUPT4H1 RPL41 ELOA3DP RPL35A RPL23A ELOA NELFB RPL3L ELOB RPS26 ELOC RPS25 NELFCD RPS28 NELFA RPS27 ELOA3BP RPS29 NELFE RPL27A RPL22L1 SUPT16H ELOA3P RPS20 FAU tat ELOA2 RPS21 SSRP1 RPL26L1 CDK9 RPS24 RPS23 H2AC19 CHD4 CHD3 ACTB H2AC14 H2BC21 H2BU1 H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2BC15 NUP107 NUP188 H2BC11 HDAC2 HDAC1 H3C15 MTA1 NUP210 RBBP4 NUP93 PPIA VCP POM121 RBBP7 MTA2 NUP205 MTA3 H2BC9 MBD3 AAAS H4C9 H2BC8 H2BC5 NUP160 POM121C H2BC3 NUP85 TPR H2BC1 NUP88 GATAD2B NUP155 GATAD2A NUP153 H2AC20 NMT1 NUP62 NDC1 NUP133 NUP50 NUP54 HDAC3 NUP42 rev NUP43 RAE1 gag-pol vif RANBP2 NMT2 vpr vpu NUP35 NUP37 VAV3 VAV1 GNG10 ELMO2 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 NFKB1 HSP90AB1 PTGES3 FKBP4 GNG3 GNG2 GNG5 GNG4 TYK2 GNG7 GNG8 ARPC1B ACTG1 COMT RANGAP1 LYN YES1 PTK2 DAXX ACE2 TMPRSS2 ST3GAL3 7a 3a PLCG1 ELMO1 CRK PABPN1 KPNA7 KPNA4 KPNA5 KPNA2 KPNA3 CPSF4 EIF2AK2 ITGB1 CYFIP1 NCKAP1 ELK1 BRK1 STX1B botF STX1A SV2C SV2B SV2A VAMP1 CYBA VAV2 NOXO1 8b ZCRB1 DDX5 9b UVRAG NCKAP1L WASF1 WASF2 BAIAP2 ABI2 ABI1 NOXA1 PML NOX1 RB1 HNRNPK ITGA4 SRC DBP CTNNB1 GTF2A1 GTF2A2 GTF2B TAF9 TAF1L GTF2E1 GTF2E2 TAF7L TAF9B TAF15 TAF12 TAF13 TAF10 TAF11 TAF7 UL36 TAF4B TAF6 TAF5 TAF4 TAF3 TAF2 TAF1 TBK1 ISG15 E MAP2K4 MAP2K7 TBL1XR1 TBL1X CEBPD EEF2 FEN1 tetX cya lef pagA FGR ITPR1 ITPR2 ITPR3 P2RX7 P2RX4 CALM1 MAPK8 DYNLL2 ADCYAP1 ADCYAP1R1 VHL ARID4B SAP30 SUDS3 EZH2 EED SAP30L SAP18 SUZ12 JUN CCNK TXN PLK2 NPM1 CCNT2 CTNND1 inlA CBLL1 CASP1 CYFIP2 VIPR1 VIPR2 AHCYL1 SCT WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 GPR176 IGKV1-16 GNAT3 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 ENTPD1 IGHV3-30 V2-17 IGHV3-33 ENTPD5 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 TXNIP V1-11 IGKV2D-30 GIPR V1-16 V1-13 IGHV1-69 MEFV CRHR1 CRHR2 GHRHR PLCG2 HMOX1 GSDMD V1-20 GPR15 IGKV2D-40 IGHV3-11 FZD7 IGHV3-13 GPR27 GPR25 GPR20 IGHV1-46 ADM PTH1R IGHV IL10 SCP LPG1G2 TXNRD1 CVC2 V5-4 CVC1 V5-1 SYK GPR32 IL18 PTH2R V5-6 HCK IL1A IL1B IGLV3-19 NEC1 RAMP2 NEC2 RAMP3 GPR45 PTH US12 GNAI3 US11 WAS US10 PRKX KDM1A GNAI1 US28 HSP90AA1 GNAI2 US27 IGLV3-25 US26 NT5E US24 IGLV3-27 US34 IGKC US32 IGLV3-21 US30 GPR150 V4-6 US19 V4-2 US18 V4-1 US17 US16 IGKV1-5 SCTR US14 US13 MYO9B GCG US23 GHRH US22 ADM2 US20 RAMP1 IGLV BTRC PRKACA IGHG3 PYCARD IGHG4 IGHG1 IGHG2 GGT1 V3-4 SKP1 V3-3 V3-2 PHF21A IGKV1D-39 IGKV1D-33 UL147A DPEP2 DPEP1 TUBB IAPP DPEP3 ABL1 GNAZ CALCA CALCB UL103 CALCRL IGHV4-59 GPR83 UL102 DYNLL1 GPR84 IGLV2-11 UL104 NCKIPSD CALCR IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 HA-33 DVL1 UBA52 IGLV1-44 IGKV3-15 DVL3 RCOR1 NLRP3 IGKV3-11 V2-8 DYNC1I2 GGT5 CALR CD163 IGLV7-43 IGKV1D-16 inlB IGKV1D-12 IPO5 IL6 IGLV1-51 IGLV2-23 IGKV3-20 UBB GLP1R PRKAR2B IGHV4-34 IGHV1-2 IGHV4-39 UBC FCGR3A PSTPIP1 CHMP1A RPS27A UL119/UL118 IGKV2-29 UL11 IGKV2-28 IGLC3 UL18 IGLC1 UL17 IGLC2 UL16 V1-9 UL14 HMG20B DYNC1H1 V1-7 UL13 V1-5 UL32 V1-3 UL31 RAC1 HELI RHBDF2 UL38 GLP2R JAK2 IGKV3D-20 UL37 GIP UL35 UL34 MYH2 CRH IGKV2-30 IGHV2-70 LIG4 IGHV2-5 IGHV3-48 IGLV3-1 UL29 PTH2 UL27 PTHLH UL26 UBE2I IGKV1-39 UL25 IGKV1-33 UL24 FCGR1A UL23 WASF3 UL54 IGHV3-53 UL52 NR3C1 IGLC7 CBX1 MYO10 UL44 IGKV5-2 UL43 DOCK2 IGLC6 UL48 DOCK1 FCGR2A UL47 SUGT1 UL76 VIP UL74 UL71 nef UL70 SUMO1 B2M UL79 HLA-A UL78 CD8B LCK PACS1 UL131A CD28 UL41A UL69 CCNH UL112/UL113 RNMT UL91 POLR2A POLR2B UL99 POLR2C UL98 POLR2D POLR2E UL97 POLR2F POLR2G UL96 POLR2H UL95 POLR2I UL94 POLR2J UL92 POLR2K POLR2L RNGTT GTF2H1 UL80 PA GTF2H2 UL88 SUPT5H PB2 UL87 NP GTF2F1 UL84 NA GTF2H3 UL83 NS GTF2H4 UL82 ntnha HA GTF2F2 M UL2 GTF2H5 UL4 PB1 CDK7 UL5 ERCC3 UL7 ERCC2 UL9 MNAT1 UL22A ha17 CLTA AP2A1 US3 US2 US9 US8 AP2A2 MCP ha70 DUT RL11 RL10 AP2M1 PSMD8 PSMD9 US33A PSMD6 US34A PSMD7 PSMD4 RL9A RL8A PSMD5 PSMD2 BANF1 PSMD3 botG PSMD1 PSMA5 botE PSMA6 botD botA PSMA3 botB PSMA4 PSIP1 PSMA1 PSMA2 PSME3 PSME4 UL15A PSME1 UL130 PSME2 UL132 PSMD10 UL133 PSMB11 UL138 PSMD12 CD9 TRM3 AP2S1 PSMD11 TRM2 PSMD14 TRM1 PSMD13 UL144 UL147 PSMA7 UL146 PSMB10 UL148 1a rep PSMA8 gB PSMB6 gH PSMB7 gL PSMB4 gM PSMB5 gN PSMB2 AP2B1 UL114 PSMB3 UL121 PSMB1 UL120 PSMF1 UL123 PAK2 UL122 DNAJC3 PSMB8 UL124 PSMB9 UL117 SEM1 PSMC5 TRS1 PSMC6 PSMC3 RL1 PSMC4 CUL5 PSMC1 PSMC2 TRX1 TRX2 UL111A RANBP1 TCEA1 UL21A GRSF1 RAN GUCY2C PDZD3 RIPK1 sta1 ST6GALNAC2 RPN2 HTR4 PRKCSH NEDD4L TUSC3 RXFP1 RPN1 RXFP2 MAGT1 FUT8 GANAB HTR6 S MAN2A1 HTR7 MGAT5 C3AR1 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 PTGDR ST6GAL1 EDEM2 MOGS TAAR8 DDOST TAAR9 TAAR6 MGAT4C DAD1 FXYD4 TAAR5 MGAT4A TAAR2 MGAT4B FXYD3 CANX FXYD2 STT3A FXYD1 MAN1B1 TAAR1 FXYD7 ST6GALNAC3 ST6GALNAC4 FXYD6 LHB C3 MC2R CGA SLC25A5 SLC25A4 SLC25A6 MC1R MC4R CCR5 GPR39 FSHB AP1S2 GPBAR1 AP1S1 AP1S3 VPS36 MC3R ADRB3 DYNC1LI1 FSHR DYNC1LI2 AVP VPS25 VPS28 PTGER4 NPSR1 PTGER2 CXCR4 SNF8 NPS ARF1 GPHA2 ARPC1A P2RY11 MC5R GPHB5 VAMP2 HBEGF CYSLTR1 CYSLTR2 EGFR LHCGR TRIM28 UBAP1 ADRB1 ADRB2 TAAR3P HRH2 DRD1 DVL2 DRD5 AP1M2 AP1M1 RLN2 RLN3 ARPC4 ATP1B3 ATP1B2 ARPC5 ATP1B1 ARPC2 ARPC3 INSL3 TSHB AP1G1 PTGIR AVPR2 ACTR2 VPS37C VPS37D VPS37A VPS37B ADORA2A ADORA2B VPS4B VPS4A ATP1A4 ATP1A3 ATP1A2 ATP1A1 S1PR1 MYO1C TSHR POMC CDH1 LIG1 PARP1 AP1B1 ADAM17 MYO5A STAM CTSL CTSG SH3KBP1 CD3G MAP1LC3B SEC13 FURIN IFNGR1 IFNGR2 JAK1 EPS15 DYNC1I1 XRCC6 XRCC5 SH3GL3 IRS1 SH3GL2 PIK3R4 SH3GL1 WNT5A CHMP4C CHMP4B CHMP4A STAM2 TSG101 TLR2 LTF TLR9 PIK3C3 SYT2 SYT1 H2AC17 H2AC12 VTA1 CHMP2B H2AC21 CHMP2A H2AW env CD4 MYH9 CHMP3 CLTC WASL CHMP6 CHMP7 CHMP5 CDC42 CBL H2AC1 NCK1 MVB12B MVB12A GALNT1 PARP10 PARP6 GSK3B XRCC4 PARP4 PARP16 PARP9 PARP14 N H2BC18 BECN1 PARP8 ZBP1 XPO1 NUP214 GPS2 NCOR2 CREB1 NCOR1 MAPK14 HSPA1A PRKACG PRKACB RBX1 ADCY9 PRKAR1B PRKAR1A BTK HMGA1 PRKAR2A PDCD6IP RIR1 GNAS ADCY4 RCC1 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 ARID4A NS5B JAK3 IL6R IL1R1 SIGMAR1 BRMS1 TLR7 IFNAR1 BRD4 CRBN STAT2 REST IMPDH1 IMPDH2 PDCD1 rpoA rpoC rpoZ Rv1281c ROCK1 msrA ROCK2 irtB irtA Rv2779c sodC sodB ahpE ahpD MRC1 ahpC katG secY secF secE Rv1280c secA1 secG secD Rv2895c MT2748 bfr pstS1 dlaT mscR Rv1283c RELA trx-2 Rv1282c NFKB2 glbN fgd1 ggt-1 trxA bfrB cpnT tpx trxB gag TGFB1 FKBP1A GLYCEROPHOSPHOLIPID BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%1483206 Glycerophospholipid biosynthesis CHKA SELENOI PISD ETNPPL PHOSPHO1 ETNK2 ETNK1 CEPT1 PLA2G4A GNPAT CSNK2A1 PLA2G2A CSNK2A2 PLD6 CSNK2B AGK ALPI PLD1 LPGAT1 TAZ PITPNB CPNE7 CPNE6 MFSD2A STARD7 PLA1A PLA2G3 LPCAT1 PGS1 PTDSS2 PTDSS1 PTPMT1 AGPAT3 TMEM86B STARD10 CHAT PEMT CDS2 DGAT2L7P OSBPL10 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PNPLA8 LPCAT3 LPCAT2 PNPLA3 ABHD4 ABHD3 PLD4 PLD3 OSBPL8 OSBPL5 DGAT2L6 HADHB CRLS1 HADHA PCTP AWAT2 MBOAT7 MBOAT1 MBOAT2 CHPT1 GPAT2 DGAT2 DGAT1 GPAM GPD2 CPNE1 CPNE3 LPIN1 LPIN2 LPIN3 MGLL SLC44A1 PLA2G6 AGPAT5 PLA2G1B PLA2G5 LCLAT1 AGPAT4 GPAT4 PLB1 LIPI LIPH ACP6 AGPAT1 GPAT3 PLA2G15 PLA2G2F CDS1 PLA2G4F PLA2G2D PLA2G12A PLA2G4D PITPNM1 PLA2G4E PITPNM3 PLA2G2E MIGA2 PLA2G4B PITPNM2 MIGA1 PLA2G4C CDIPT PLBD1 DDHD2 GPCPD1 DDHD1 LPCAT4 GPD1 ACHE PLA2G10 BCHE GPD1L PLA2R1 SLC44A5 SLC44A3 SLC44A4 SLC44A2 AGPAT2 PLD2 PNPLA2 CHKB PCYT2 TRANSPORT OF THE SLBP DEPENDANT MATURE MRNA%REACTOME%R-HSA-159230.2 Transport of the SLBP Dependant Mature mRNA NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 SLBP NUP155 EIF4E NCBP1 NUP214 NUP153 NCBP2 NXF1 SEC13 NUP62 NDC1 ALYREF NUP133 NUP107 NUP188 NUP50 NUP54 DEFENSINS%REACTOME%R-HSA-1461973.1 Defensins DEFB125 DEFB124 DEFB123 DEFB121 DEFB107B ART1 DEFA1B DEFB104B DEFA6 DEFA4 DEFA5 DEFB136 DEFA3 DEFB135 DEFB134 DEFB133 env DEFB108B DEFB132 DEFB108C CD4 DEFB105B DEFB1 DEFB109B PRSS3 DEFB106B DEFB119 DEFB118 DEFB117 DEFB116 DEFB115 DEFB114 DEFB113 DEFB112 DEFB110 TLR1 PRSS2 DEFB130A CCR6 DEFB130B DEFB4B TLR2 CCR2 DEFB103B DEFB129 DEFB131A DEFB128 DEFB127 DEFB126 VESICLE-MEDIATED TRANSPORT%REACTOME%R-HSA-5653656.2 Vesicle-mediated transport V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 F8 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 KIF28P HSP90AA1 IGLV3-25 KIF5C KIF5B IGLV3-27 KIF5A IGKC HGS IGLV3-21 RAB5A KIF21A YWHAE KIF21B V4-6 KIFAP3 V4-2 RAB7A V4-1 IGKV1-5 ACTR1A KIF16B KIF20A KIF20B IGLV RAB8A YWHAG KLC1 V3-4 V3-3 V3-2 IGKV1D-39 KLC4 IGKV1D-33 KLC3 KLC2 KIF3B KIF3C CSNK1D IGHV4-59 DYNLL1 IGLV2-11 HP IGLV1-40 KIF18A IGLV1-47 KIF18B IGLV6-57 IGLV2-14 KIF4B UBA52 IGLV1-44 KIF4A IGKV3-15 OPTN PAFAH1B1 IGKV3-11 V2-8 DYNC1I2 DCTN2 CD163 CALR IGLV7-43 DCTN3 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 UBB IGKV3-20 IGHV4-34 HBB IGHV1-2 KIF12 IGHV4-39 UBC KIF11 RPS27A KIF15 IGKV2-29 MASP1 IGKV2-28 KIF19 IGLC3 CAPZB IGLC1 IGLC2 V1-9 KIF13B V1-7 DYNC1H1 V1-5 KIF1C V1-3 KIF1B RAC1 KIF1A IGKV3D-20 KIF25 KIF23 KIF22 IGKV2-30 IGHV2-70 IGHV2-5 KIF6 IGHV3-48 KIF27 IGLV3-1 KIF9 COLEC11 KIF2A IGKV1-39 KIFC2 IGKV1-33 KIFC1 IGHV3-53 KIF2C IGLC7 KIF2B IGKV5-2 IGLC6 CENPE KIF26A KIF26B CAPZA1 CAPZA2 VPS45 LRP1 CLTA AP2A1 AP2A2 LDLRAP1 AP2M1 APOA1 SAR1B HSP90B1 AP2S1 APOE LDLR AP2B1 ALB COPS7B COPS7A COPS3 APOL1 COPS6 COPS5 COPS8 APP MAN2A1 AGTR1 CPD PICALM ITSN2 USP6NL SCOC ITSN1 FNBP1L RABGEF1 GJA1 GJA3 TFG GJA5 AKT3 GJA4 AP1S2 AP1S1 GJA9 AP1S3 GJA8 TACR1 VPS36 GABARAPL2 FNBP1 SYTL1 GAPVD1 DYNC1LI1 DYNC1LI2 BIN1 AVP VPS25 VPS28 PLA2G6 GNS GABARAP GJC1 BLOC1S4 BLOC1S6 GJC2 BLOC1S1 BLOC1S3 VTI1A SFN PIP5K1C SNAPIN CCZ1B FZD4 RAB3IP LNPEP SNF8 GJB2 GJB1 GJB4 GJB3 GJB6 GJB5 GJB7 ARF3 DENND1C DENND1B ARF4 ARF1 SERPINA1 DENND1A ARPC1A CLTB STON1 CHM STON2 CLINT1 AREG AP3S1 SLC18A3 DENND2D DENND2C EXOC8 EXOC7 DENND2B DENND2A COPZ2 RAB3IL1 EPS15L1 SAA1 COPZ1 GJD2 VAMP8 GJD4 GJD3 VAMP7 EXOC4 EXOC3 CHRM2 EXOC6 EXOC5 VAMP4 PAFAH1B3 EXOC2 VAMP2 PAFAH1B2 ARF5 EXOC1 HBEGF ARF6 NBAS TMF1 USO1 EGFR AKT2 GGA2 GGA1 ARFRP1 GGA3 LMAN2 STX6 STX5 STX4 CHML TSC2 RIC1 TSC1 TRAPPC10 ARCN1 SNX18 UBAP1 RAB3A ADRB2 GOLIM4 RAB43 RAB41 TPD52 RALGAPA2 RAB32 RINT1 RAB30 RALGAPB RAB31 RAB36 RAB35 RAB38 FTL HBA2 GRIA1 RAB5B COL1A1 RAB5C COL3A1 ARL1 RHOBTB3 COL1A2 CLTCL1 STAB2 DVL2 AP4S1 COL4A2 RAB6A COL4A1 KIAA0319 RAB6B AP1M2 COL7A1 AP1M1 TXNDC5 TRAPPC2 ANKRD28 TRAPPC3 SEC16B RAB4A TOR1A TRAPPC1 ANKRD27 TRAPPC4 SEC16A TRAPPC5 HPS1 HPS4 M6PR ARPC4 TFRC TRAPPC8 SYNJ2 ARPC5 TRAPPC9 SNAP23 TOR1B DAB2 CNIH1 SYNJ1 ARPC2 ARPC3 AAK1 CNIH2 CNIH3 MCFD2 ARRB1 ARRB2 PIK3C2A BICD1 BICD2 AP4M1 PPP6C AP1G2 AP1G1 PPP6R1 PPP6R3 SNAP29 AVPR2 SH3D19 ACTR2 SGIP1 OCRL VPS37C VPS37D VPS37A VPS37B ARFGAP3 SPTB ARFGAP1 BET1L VAMP3 ARFGAP2 DNAJC6 SEC22B SEC22A SEC22C RAB1A SEC23A VPS4B LMAN1 RAB1B VPS4A DENND3 LRP2 RAB21 RACGAP1 FCHO1 VPS51 VPS53 FCHO2 VPS52 UBQLN1 VPS54 UBQLN2 YKT6 SEC24B SEC24A HIP1R TPD52L1 RAB10 NECAP2 MYO1C NECAP1 RAB14 SYT11 RAB12 RAB13 RAB18 SEC24D SEC24C HPR FOLR1 HPX BET1 IGHA1 KDELR1 IGHA2 GCC2 AMBP GCC1 GOLGA2 JCHAIN GOLGA4 GOLGA5 RINL FTH1 GOLGA1 TBC1D10C ARFIP2 TBC1D10A AGFG1 TBC1D10B COG8 COG7 COG6 LMAN1L COG5 COG4 COG3 AP1B1 COG2 COG1 ANK2 ANK3 ANK1 EREG BTC ZW10 ULK1 PREB RIN3 KDELR2 KDELR3 RIN1 RIN2 CFTR SPTBN4 SPTBN5 STXBP3 LMAN2L TGFA TGOLN2 SCFD1 SNX2 GJA10 SNX9 SNX5 SEC31A SPTBN2 TBC1D8B SURF4 RAB39A MYO5A RAB27A RAB39B RAB27B STAM PUM1 SNAP91 TF MON1A MON1B C2CD5 HIP1 GDI1 SH3KBP1 CTSZ GDI2 AP4E1 MIA2 MIA3 CD3G CD3D MAP1LC3B TMED3 TMED2 TMED7 CTSC RAB8B SEC13 TMED9 AP3B1 RAB33A RAB33B GAK CTTN RAB7B RHOQ NAPA NAPB RABGAP1 STX17 STX16 STX18 NEDD8 NAPG STX10 ALS2CL CUX1 CD59 EPS15 DYNC1I1 CD55 SORT1 GBF1 RAB11A RAB11B TJP1 RGP1 SEC23IP EPGN CAPZA3 TRIP10 YIPF6 F5 TRIP11 RAB3GAP2 RAB9A COPG2 COPG1 ACTR10 RAB9B RAB3GAP1 SCARB2 SH3GL3 SYS1 DENND5B TRAPPC12 TRAPPC11 DENND5A TRAPPC13 SBF1 SBF2 SH3GL2 SH3GL1 NSF TRAPPC2L WNT5A TBC1D20 TBC1D24 CHMP4C CHMP4B AMPH DENND6B CHMP4A DENND6A STAM2 COPB2 COPA TMED10 TSG101 COPB1 SPTA1 GRK3 GRK2 MAN2A2 PACSIN2 TBC1D13 PACSIN3 TBC1D14 TBC1D17 TBC1D15 PACSIN1 TBC1D16 SYT2 SYT1 DENND4B DENND4A VTA1 DENND4C ASPSCR1 CCZ1 SYT9 AP4B1 SYT8 IGF2R PLA2G4A TMEM115 ALPP CHMP2B CHMP2A ACBD3 COPE SLC2A4 USE1 RABEPK SLC2A8 YWHAQ MAN1A2 MAN1A1 YWHAH NAA30 EPN1 DNM1 DNM2 CD4 EPN2 DNM3 TBC1D1 TRAPPC6A TBC1D2 HSPA8 RABEP1 PRKAB2 APOB TBC1D3 PRKAA2 TBC1D4 PRKAG1 ALS2 PLIN3 TRAPPC6B PRKAG2 GORASP1 TBC1D7 PRKAB1 MYH9 PRKAG3 CHMP3 NAA35 CLTC DNASE2 WASL NAA38 CHMP6 CHMP7 CHMP5 DCTN6 DCTN5 RALA DCTN1 GOSR2 CALM1 DCTN4 GOSR1 SPTAN1 CBL DYNLL2 AGPAT3 SPTBN1 INS CYTH3 CYTH2 CYTH4 MVB12B REPS2 CLVS2 BNIP1 MAN1C1 MVB12A CYTH1 REPS1 CLVS1 GALNT2 EGF GALNT1 DTNBP1 YWHAB AKT1 YWHAZ HSPH1 porB KIF3A CD36 HYOU1 SCARF1 SCARA5 MSR1 SSC5D MARCO SCGB3A2 STAB1 COLEC12 GPS1 COPS4 COPS2 MYO6 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 SPARC V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 OPIOID SIGNALLING%REACTOME DATABASE ID RELEASE 76%111885 Opioid Signalling PLCB3 PLCB1 GNAL PPP2R1B PLCB2 PPP3R1 KPNA2 PRKACG PRKACB PLA2G4A PPP2R5D PLCB4 ADCY9 PRKAR1B CAMKK1 PPP1R1B CAMKK2 PRKAR1A MAPK1 PDE1B PDE1A PRKAR2A ITPR1 ITPR2 GNG10 ITPR3 GNAI3 PPP2CA PRKX PPP2CB GNG12 GNAI1 GNG11 PDE4B GNAI2 GNG13 PDE4A NBEA GNB2 PDE4D GNAQ PDE4C GNB1 PDE1C GNB4 ADCY4 GNB3 OPRM1 ADCY3 ADCY2 GNB5 ADCY1 PPP2R1A PDYN ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 PRKACA CALM1 PRKCG GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 CDK5 GNG8 POMC AHCYL1 PRKCD PRKCA CAMK2B PRKAR2B GNAT3 CAMK2D CAMK2A CAMK2G PPP3CC CREB1 CAMK4 PPP1CA GRK2 PPP3CA PPP3CB ANCHORING FIBRIL FORMATION%REACTOME DATABASE ID RELEASE 76%2214320 Anchoring fibril formation LAMC2 LAMB3 COL7A1 LAMA3 TLL2 BMP1 TLL1 RHOJ GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013409 RHOJ GTPase cycle RHOJ FNBP1 IQGAP3 TRIO TFRC JUP SNAP23 PAK3 ARHGAP1 ARHGAP5 STEAP3 ARHGAP35 PREX1 SYDE1 WAS OPHN1 TMPO WWP2 RAB7A OCRL WASL PIK3R1 CDC42EP1 CDC42 PAK1 VAMP3 FMNL3 GIT1 PIK3R2 SLC1A5 GIT2 ARHGAP21 VANGL1 DEPDC1B ARHGEF7 PAK4 CAV1 STOM ARHGAP26 MPP7 SLC4A7 ARHGAP32 DIAPH3 WIPF2 NIPSNAP2 DOCK8 SCRIB PAK2 CDC42BPB CDC42BPA CPNE8 LAMTOR1 ARL13B FNBP1L GJA1 MRNA SPLICING%REACTOME DATABASE ID RELEASE 76%72172 mRNA Splicing CSTF2 PABPN1 CPSF1 CPSF4 HSPA8 DHX9 ZCRB1 DDX5 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 SNRPD3 SRRM2 CRNKL1 ELAVL1 CD2BP2 SF1 CSTF3 SNU13 NCBP1 RNPC3 PCBP1 NCBP2 CSTF1 SYMPK ZRSR2 PRPF38A HNRNPL HNRNPM HNRNPK HNRNPF SUGP1 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SRSF10 SF3A3 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 PRPF31 PDCD7 CWC25 CWC27 EFTUD2 CWC22 PAPOLA MTREX TXNL4A SNRNP35 SNRPN SNW1 WBP11 PRPF4 PRPF6 HNRNPUL1 PRPF3 EIF4A3 SNRPG CASC3 SNRNP27 PPIH MAGOH SNRPE SNRPF SNRNP25 POLR2A SNRPC POLR2B SNRNP200 POLR2C CDC40 SNRPA POLR2D SNRPB POLR2E PRPF8 POLR2F ZMAT5 POLR2G FUS POLR2H CPSF3 POLR2I CPSF2 POLR2J SRSF2 CWC15 POLR2K SRSF3 LSM5 POLR2L SRSF4 LSM4 SRSF5 LSM3 SRSF6 LSM2 SRSF7 CHERP GTF2F1 LSM8 SLU7 SRSF9 LSM7 LSM6 GTF2F2 DDX46 RBM8A DDX42 PPWD1 YBX1 SRSF1 USP39 U2AF1 ELAVL2 U2AF1L4 PTBP1 PCBP2 SART1 U2AF2 DHX38 SNRNP70 SRSF11 RBM5 ALYREF BCAS2 UPF3B CTNNBL1 MAGOHB RBM17 BUD31 RNPS1 TFIP11 PLRG1 SYF2 SNRPA1 DNAJC8 RBM22 WBP4 DDX23 PRCC CSTF2T PUF60 FIP1L1 SNRPB2 HNRNPA1 SMNDC1 HNRNPA0 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP CPSF7 SNRNP40 SF3B1 SNRNP48 PPIL3 PPIL4 PPIL6 SRRM1 TRA2B HNRNPC RBMX ISY1 PRPF19 AQR PPIE XAB2 CLP1 SEMA4D MEDIATED INHIBITION OF CELL ATTACHMENT AND MIGRATION%REACTOME DATABASE ID RELEASE 76%416550 Sema4D mediated inhibition of cell attachment and migration SEMA4D RAC1 RRAS MET PLXNB1 RHOA ARHGAP35 RND1 PEROXISOMAL PROTEIN IMPORT%REACTOME DATABASE ID RELEASE 76%9033241 Peroxisomal protein import PEX26 DDO SCP2 NUDT19 LONP2 MPV17 PHYH ECH1 GNPAT ACOT2 IDE HMGCL HSD17B4 HACL1 HAO2 NOS2 EPHX2 ACOT8 EHHADH TYSND1 DECR2 ACAA1 UBE2D2 ACOT4 UBE2D3 CROT BAAT UBE2D1 CAT PEX2 AMACR ACOX2 PEX1 PIPOX PEX7 SLC27A2 ACOX1 PEX6 AGPS ACOX3 USP9X PEX10 PEX12 UBA52 PEX13 PEX14 DHRS4 DAO NUDT7 CRAT UBB UBC RPS27A HAO1 AGXT GSTK1 PAOX IDH1 PECR ZFAND6 EXTENSION OF TELOMERES%REACTOME%R-HSA-180786.2 Extension of Telomeres CCNA1 POLD2 BLM NOP10 ANKRD28 CDK2 PRIM2 PRIM1 POLA1 POLA2 PCNA RFC5 RFC3 RFC4 PPP6C RFC2 DSCC1 RUVBL2 PPP6R3 SHQ1 ACD TINF2 PIF1 WRN TERF1 CHTF8 TERF2 TERT CTC1 WRAP53 CHTF18 RPA1 POT1 STN1 RPA2 TERF2IP TEN1 RPA3 RTEL1 RUVBL1 LIG1 DKC1 RFC1 NHP2 GAR1 POLD3 FEN1 POLD4 CCNA2 DNA2 POLD1 MATURATION OF PROTEIN M%REACTOME%R-HSA-9694594.1 Maturation of protein M M ACTIVATION OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68962.4 Activation of the pre-replicative complex MCM10 DBF4 POLE4 RPA4 POLE2 CDK2 POLE3 PRIM2 PRIM1 POLA1 POLA2 CDC45 CDC7 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 POLE ORC2 CDT1 CDC6 RPA1 RPA2 RPA3 GMNN DEFECTIVE TPMT CAUSES TPMT DEFICIENCY%REACTOME%R-HSA-5578995.2 Defective TPMT causes TPMT deficiency TPMT DEFECTIVE GIF CAUSES INTRINSIC FACTOR DEFICIENCY%REACTOME DATABASE ID RELEASE 76%3359457 Defective GIF causes intrinsic factor deficiency CBLIF DOWNSTREAM SIGNALING OF ACTIVATED FGFR2%REACTOME DATABASE ID RELEASE 76%5654696 Downstream signaling of activated FGFR2 HRAS GAB1 FGF1 FGF2 PIK3CA FGF3 PLCG1 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF7 FGF9 FGF20 FGF23 PIK3R1 FGF22 FRS2 FGF16 FGF18 FGF10 CELL REDOX HOMEOSTASIS%REACTOME DATABASE ID RELEASE 76%1222541 Cell redox homeostasis trxB dlaT ahpD ahpC trx-2 fgd1 trxA lpdC tpx APOPTOTIC FACTOR-MEDIATED RESPONSE%REACTOME DATABASE ID RELEASE 76%111471 Apoptotic factor-mediated response GSDMD BAK1 C1QBP CDKN2A AVEN APAF1 CASP9 CASP7 DIABLO UACA CARD8 GSDME XIAP BAX MAPK1 CASP3 MAPK3 APIP CYCS O-LINKED GLYCOSYLATION OF MUCINS%REACTOME%R-HSA-913709.3 O-linked glycosylation of mucins ST3GAL3 B3GNT9 B3GNT8 B3GNT6 B3GNT5 CHST4 GALNT11 GALNT14 ST6GALNAC2 GALNT13 MUC1 GALNT16 GALNT15 MUC2 GALNT18 GALNT17 GALNT10 MUC7 MUC4 MUC6 ST3GAL4 ST3GAL1 ST3GAL2 ST6GAL1 B3GNT7 B3GNT4 B3GNT3 B3GNT2 ST6GALNAC3 B4GALT6 ST6GALNAC4 MUC5AC B4GALT5 B3GNTL1 C1GALT1C1 MUC12 GALNT9 MUC15 GALNT8 MUC3A GALNT7 GALNT6 MUC3B GALNT5 GALNT4 GALNT2 MUC16 MUC17 GALNT1 GALNT3 MUC19 MUC20 MUC21 GALNTL5 GALNTL6 MUC5B GCNT1 GCNT3 GCNT4 GCNT7 MUC13 A4GNT MUCL1 C1GALT1 GALNT12 REGULATION OF TP53 ACTIVITY THROUGH METHYLATION%REACTOME DATABASE ID RELEASE 76%6804760 Regulation of TP53 Activity through Methylation L3MBTL1 UBB PRMT5 TP53 UBC SMYD2 EP300 MDM2 RPS27A ATM MDM4 JMY EHMT1 UBA52 SETD9 TTC5 KMT5A CHEK2 EHMT2 DISEASES ASSOCIATED WITH VISUAL TRANSDUCTION%REACTOME%R-HSA-2474795.3 Diseases associated with visual transduction TTR ABCA4 OPN1LW LRAT OPN1MW RBP4 NAPEPLD STRA6 RBP1 RLBP1 RDH5 OPN1SW RDH12 FORMATION OF ATP BY CHEMIOSMOTIC COUPLING%REACTOME%R-HSA-163210.2 Formation of ATP by chemiosmotic coupling ATP5PO MT-ATP6 ATP5F1A ATP5F1B ATP5MC2 ATP5MC3 ATP5MG ATP5MF ATP5ME DMAC2L ATP5MC1 ATP5PF ATP5PD ATP5PB ATP5F1C ATP5F1D ATP5F1E MT-ATP8 TELOMERE C-STRAND (LAGGING STRAND) SYNTHESIS%REACTOME%R-HSA-174417.3 Telomere C-strand (Lagging Strand) Synthesis POLD2 BLM PRIM2 PRIM1 POLA1 POLA2 PCNA RFC5 RFC3 RFC4 RFC2 DSCC1 LIG1 ACD RFC1 WRN TINF2 CHTF8 TERF1 TERF2 CTC1 CHTF18 RPA1 STN1 RPA2 POT1 TERF2IP TEN1 RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 VITAMIN C (ASCORBATE) METABOLISM%REACTOME DATABASE ID RELEASE 76%196836 Vitamin C (ascorbate) metabolism CYB5A GSTO2 GSTO1 SLC2A3 SLC23A2 SLC23A1 SLC2A1 CYB5R3 VEGF LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 76%194313 VEGF ligand-receptor interactions FLT1 FLT4 VEGFB KDR VEGFC VEGFD PGF VEGFA STAT5 ACTIVATION DOWNSTREAM OF FLT3 ITD MUTANTS%REACTOME DATABASE ID RELEASE 76%9702518 STAT5 activation downstream of FLT3 ITD mutants PIM1 STAT5A STAT5B NOX4 GAB2 BCL2L1 GRB2 CDKN1A FLT3 PTPN11 DEFECTIVE SLC34A3 CAUSES HEREDITARY HYPOPHOSPHATEMIC RICKETS WITH HYPERCALCIURIA (HHRH)%REACTOME%R-HSA-5619097.1 Defective SLC34A3 causes Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) SLC34A3 SIGNALING BY VEGF%REACTOME%R-HSA-194138.2 Signaling by VEGF PRKCB MAPKAP1 AAMP CYFIP1 NCKAP1 NCF1 JUP NCF2 FYN PRR5 VAV3 PAK3 NCF4 BRK1 VAV1 ITPR1 ELMO2 ITPR2 ITPR3 HSP90AA1 NOS3 PDPK1 CYBB CYBA RICTOR PIK3R1 VAV2 PRKACA CDC42 TRIB3 PAK1 NCK2 SPHK1 CALM1 PIK3R2 NCK1 NCKAP1L SHB CDH5 WASF1 SH2D2A PTK2B WASF2 AXL CAV1 BAIAP2 HSPB1 ABI2 ABI1 AKT1 PRKCD PRKCA PTK2 FLT1 FLT4 VEGFB KDR MAPKAPK2 VEGFC VEGFD PGF VEGFA ITGB3 ITGAV RAC1 MAPK14 MAPK11 AKT3 WASF3 DOCK1 CTNNA1 PIK3CA PLCG1 CTNNB1 PRKACG PRKACB NRP1 CTNND1 NRP2 SHC2 ELMO1 CRK PXN ROCK1 ROCK2 BCAR1 CYFIP2 AKT2 MLST8 AHCYL1 MAPK12 MAPK13 MAPKAPK3 MTOR HRAS PAK2 PIK3CB RASA1 NRAS THEM4 PRKCZ RHOA TRANSCRIPTION OF SARS-COV-2 SGRNAS%REACTOME DATABASE ID RELEASE 76%9694786 Transcription of SARS-CoV-2 sgRNAs N rep NTRK3 AS A DEPENDENCE RECEPTOR%REACTOME%R-HSA-9603505.1 NTRK3 as a dependence receptor NELFB BAX NTRK3 ADENYLATE CYCLASE INHIBITORY PATHWAY%REACTOME%R-HSA-170670.3 Adenylate cyclase inhibitory pathway GNAI1 GNAL GNAI2 GNAT3 ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY9 ADCY5 GNAI3 REGULATION OF THE APOPTOSOME ACTIVITY%REACTOME DATABASE ID RELEASE 76%9627069 Regulation of the apoptosome activity XIAP MAPK1 AVEN CASP9 APAF1 DIABLO MAPK3 APIP UACA CARD8 CYCS RAB GERANYLGERANYLATION%REACTOME DATABASE ID RELEASE 76%8873719 RAB geranylgeranylation RAB6B RAB15 RAB19 RAB17 RAB4A RAB39A RAB27A RAB39B RAB27B RAB2A RAB5A RAB7A RAB8B RAB33A CHM RAB33B RAB22A RAB7B RAB8A RAB1A RAB1B RAB21 RAB40A RAB40B RAB40C RAB11A RABGGTB RAB11B RABGGTA RAB3D RAB44 RAB10 RAB9A RAB14 RAB12 RAB13 RAB9B RAB18 RAB37 CHML RAB4B RAB3B RAB3C RAB3A RAB42 RAB43 RAB41 RAB2B RAB32 RAB34 RAB30 RAB31 RAB36 RAB35 RAB38 RAB24 PTP4A2 RAB5B RAB5C RAB20 RAB25 RAB26 RAB23 RAB6A RAB29 SUMOYLATION OF SUMOYLATION PROTEINS%REACTOME%R-HSA-4085377.3 SUMOylation of SUMOylation proteins NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 SUMO1 NUP205 SUMO2 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP214 NUP153 TOPORS SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 PIAS4 NUP50 NUP54 UBE2I CASPASE-MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS%REACTOME%R-HSA-264870.1 Caspase-mediated cleavage of cytoskeletal proteins MAPT PLEC CASP6 CASP7 GSN CASP3 VIM CASP8 SPTAN1 DBNL ADD1 GAS2 TP53 REGULATES TRANSCRIPTION OF CASPASE ACTIVATORS AND CASPASES%REACTOME%R-HSA-6803207.1 TP53 Regulates Transcription of Caspase Activators and Caspases CASP2 NLRC4 TP53 TP73 PIDD1 CASP6 CASP10 CASP1 APAF1 ATM TP63 CRADD FGFR2 ALTERNATIVE SPLICING%REACTOME%R-HSA-6803529.2 FGFR2 alternative splicing HNRNPA1 TIAL1 TIA1 RBFOX2 ESRP2 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2F1 HNRNPM GTF2F2 HNRNPF PTBP1 HNRNPH1 ESRP1 BBSOME-MEDIATED CARGO-TARGETING TO CILIUM%REACTOME DATABASE ID RELEASE 76%5620922 BBSome-mediated cargo-targeting to cilium BBS9 BBS7 BBS5 BBS4 MKKS LZTFL1 MCHR1 BBS10 BBS12 CCT2 ARL6 SSTR3 CCT8 CCT5 SMO CCT4 BBS2 CCT3 BBS1 BBIP1 TTC8 TCP1 RAB3IP FGFR2 LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190241.1 FGFR2 ligand binding and activation FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGFBP1 FGF9 FGFBP2 FGF20 FGFBP3 FGF23 FGF22 FGF16 FGF18 FGF10 RNA POLYMERASE I PROMOTER OPENING%REACTOME DATABASE ID RELEASE 76%73728 RNA Polymerase I Promoter Opening H3C15 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 MAPK3 H2AX H2AB1 H2AC20 H2AC19 MBD2 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 UBTF H2BC14 H2AJ H2BC15 H2BC11 PROCESSIVE SYNTHESIS ON THE LAGGING STRAND%REACTOME%R-HSA-69183.2 Processive synthesis on the lagging strand POLD2 PRIM2 LIG1 PRIM1 POLA1 POLA2 PCNA RPA1 RPA2 RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 SIGNALING BY MODERATE KINASE ACTIVITY BRAF MUTANTS%REACTOME%R-HSA-6802946.1 Signaling by moderate kinase activity BRAF mutants BRAP FN1 BRAF FGB FGA VWF KRAS FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CAMK2B PHB CSK CAMK2D HRAS CAMK2A MARK3 MAP3K11 CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 JAK2 KSR2 CALM1 SRC DEFECTS IN VITAMIN AND COFACTOR METABOLISM%REACTOME%R-HSA-3296482.3 Defects in vitamin and cofactor metabolism MTRR PCCB ACACA CD320 ABCD4 MMAA LMBRD1 MMUT MMACHC CBLIF TCN2 MMAB MCCC2 CUBN PC PCCA AMN MTR HLCS MMADHC MCCC1 BTD TOXICITY OF BOTULINUM TOXIN TYPE B (BOTB)%REACTOME%R-HSA-5250958.2 Toxicity of botulinum toxin type B (botB) HA-33 SYT2 SYT1 ha70 ntnha botB VAMP2 ha17 EXTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 76%140834 Extrinsic Pathway of Fibrin Clot Formation TFPI F3 F7 F9 F10 INTRAFLAGELLAR TRANSPORT%REACTOME%R-HSA-5620924.3 Intraflagellar transport KIF3B KIF3C DYNLL1 IFT172 DYNC2H1 TTC26 IFT88 DYNC2I1 TRIP11 TRAF3IP1 DYNLT2B KIF17 HSPB11 DYNC2LI1 IFT74 KIF3A DYNLT5 TTC21B DYNLT2 IFT80 IFT20 IFT122 IFT22 IFT43 TNPO1 TTC30B IFT81 TTC30A IFT27 DYNLRB2 DYNLRB1 IFT52 IFT46 CLUAP1 IFT57 IFT140 WDR35 KIFAP3 WDR19 DYNLL2 METABOLISM OF POLYAMINES%REACTOME%R-HSA-351202.3 Metabolism of polyamines SRM ODC1 NQO1 AGMAT SAT1 PSMD8 PSMD9 SMS PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 AZIN2 PSME1 PSME2 AZIN1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 AMD1 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 OAZ1 PSMB3 OAZ2 PSMB1 PSMF1 OAZ3 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAOX BETA OXIDATION OF DECANOYL-COA TO OCTANOYL-COA-COA%REACTOME DATABASE ID RELEASE 76%77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA HADHB HADH HADHA MECR ECHS1 ACADM MITOCHONDRIAL TRANSLATION INITIATION%REACTOME%R-HSA-5368286.1 Mitochondrial translation initiation MTFMT MRPS17 MRPS15 MRPS16 MTIF2 MRPS14 MTIF3 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPS18B MRPL49 MRPS18A MRPS2 MRPS21 MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPL44 MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 G-PROTEIN BETA:GAMMA SIGNALLING%REACTOME DATABASE ID RELEASE 76%397795 G-protein beta:gamma signalling PLCB3 PLCB1 PLCB2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 ARHGEF6 BTK AKT2 GNG10 AKT1 GNG12 GNG11 GNG13 GNB2 GNB1 PDPK1 GNB4 PIK3R6 PIK3CG GNB3 PIK3R5 GNB5 GNGT1 GNGT2 CDC42 PAK1 RHOA AKT3 DEFECTIVE FACTOR IX CAUSES HEMOPHILIA B%REACTOME%R-HSA-9668250.1 Defective factor IX causes hemophilia B GP5 GP9 F9 F8 F10 GGCX GP1BB F11 GP1BA METHIONINE SALVAGE PATHWAY%REACTOME DATABASE ID RELEASE 76%1237112 Methionine salvage pathway MRI1 MTAP ENOPH1 GOT1 ADI1 APIP DEPOLYMERISATION OF THE NUCLEAR LAMINA%REACTOME%R-HSA-4419969.1 Depolymerisation of the Nuclear Lamina LPIN2 LPIN3 PRKCA PRKCB LMNB1 EMD LEMD2 CTDNEP1 CNEP1R1 LEMD3 CDK1 CCNB1 LPIN1 RESISTANCE OF ERBB2 KD MUTANTS TO OSIMERTINIB%REACTOME DATABASE ID RELEASE 76%9665247 Resistance of ERBB2 KD mutants to osimertinib HSP90AA1 CDC37 ERBB2 ERBIN POST-CHAPERONIN TUBULIN FOLDING PATHWAY%REACTOME DATABASE ID RELEASE 76%389977 Post-chaperonin tubulin folding pathway TBCA TUBAL3 TUBB6 TUBA3E TUBB3 TUBB1 TBCE TUBA3D TUBA3C TUBA4A TUBA1A TUBA8 TUBB4B TUBA1C TUBB4A TUBA1B TUBA4B TUBB2B ARL2 TUBB2A TBCD TBCC TBCB TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM%REACTOME DATABASE ID RELEASE 76%72202 Transport of Mature Transcript to Cytoplasm NUP42 NUP43 RAE1 CPSF1 RANBP2 CPSF4 NXT1 NUP35 EIF4A3 CASC3 NUP37 GLE1 MAGOH THOC1 THOC3 THOC2 THOC5 CDC40 THOC7 THOC6 DDX39A DDX39B ZC3H11A CPSF3 SARNP CPSF2 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 NXF1 SEC13 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB NXF2B RNPS1 NUP107 NUP188 FIP1L1 NUP210 NUP93 POM121 NUP205 SRRM1 AAAS NUP160 POM121C NUP85 TPR NUP88 SLBP NUP155 EIF4E NCBP1 NUP214 NUP153 NCBP2 SYMPK WDR33 NUP62 NDC1 NUP133 NUP50 NUP54 GOLGI ASSOCIATED VESICLE BIOGENESIS%REACTOME%R-HSA-432722.3 Golgi Associated Vesicle Biogenesis AP1S2 AP1M2 AP1S1 AP1M1 TXNDC5 AP1S3 TGOLN2 SNX2 AP4B1 SNX9 SNX5 IGF2R TBC1D8B TFRC ACBD3 BLOC1S4 BLOC1S6 BLOC1S1 BLOC1S3 PUM1 SNAPIN DNM2 ARRB1 PIK3C2A AP4E1 HSPA8 AP1G1 ARF1 SH3D19 OCRL AP3B1 GAK CLINT1 AP3S1 NAPA DNAJC6 VAMP8 VAMP7 SORT1 DTNBP1 VAMP2 HIP1R TPD52L1 YIPF6 NECAP1 SH3GL2 FTH1 TPD52 CPD PICALM AP1B1 FTL RAB5C PEROXISOMAL LIPID METABOLISM%REACTOME DATABASE ID RELEASE 76%390918 Peroxisomal lipid metabolism ACOT8 EHHADH DECR2 ACOT6 ACBD5 ACAA1 ACOXL ACOT4 NUDT19 PHYH CROT ABCD1 NUDT7 AMACR ACOX2 ACBD4 CRAT HSD17B4 SLC25A17 HACL1 SLC27A2 HAO2 PECR ACOX3 S45 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 76%5358751 S45 mutants of beta-catenin aren't phosphorylated PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 DEFECTIVE SLC6A19 CAUSES HARTNUP DISORDER (HND)%REACTOME DATABASE ID RELEASE 76%5619044 Defective SLC6A19 causes Hartnup disorder (HND) SLC6A19 PPARA ACTIVATES GENE EXPRESSION%REACTOME DATABASE ID RELEASE 76%1989781 PPARA activates gene expression CREBBP HDAC3 ACSL1 FADS1 RXRB TXNRD1 CYP1A1 CPT2 PPARGC1B AHRR CDK8 PLIN2 ARNT2 SLC27A1 TRIB3 MED8 MED16 MED4 MED15 MED6 MED17 MED7 MED12 MED14 MED13 MED10 AHR MED27 MED26 MED23 MED25 MED24 MED20 PEX11A FHL2 GPS2 ANKRD1 ACADM TNFRSF21 G0S2 GRHL1 NCOR2 NCOR1 CYP4A11 FABP1 ARNT NR1H2 RORA FDFT1 NFYA HMGCS1 CLOCK NFYB NFYC NPAS2 UGT1A9 ARNTL RXRA SREBF2 SP1 PPARG PPARGC1A MTF1 NR1D1 PPARA GLIPR1 CD36 HMGCS2 CYP7A1 TIAM2 MED30 MED31 EP300 NR1H4 ESRRA MED19 MED18 MED11 AGT MED29 MED28 APOA2 MED22 ALAS1 APOA1 MED21 APOA5 ANGPTL4 MED13L ABCB4 NRF1 NCOA3 MED9 ABCA1 NR1H3 NCOA1 MED1 NCOA2 CPT1A CDK19 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 RGL1 CARM1 TBL1X CCNC SULT2A1 ME1 THRAP3 FAM120B MET ACTIVATES PTK2 SIGNALING%REACTOME DATABASE ID RELEASE 76%8874081 MET activates PTK2 signaling LAMB3 PTK2 HGF LAMB1 ITGB1 LAMC2 LAMC1 ITGA2 LAMC3 LAMA5 LAMA2 LAMA1 LAMB2 MET LAMA3 ITGA3 SRC LAMA4 G1 S TRANSITION%REACTOME DATABASE ID RELEASE 76%69206 G1 S Transition PPP2R1B PPP2CA PPP2CB RRM2 PPP2R1A RPA1 RPA2 RPA3 SKP1 LIN54 LIN52 CDC7 UBA52 LIN37 LIN9 PPP2R3B CUL1 AKT1 CCNB1 UBB RB1 TFDP1 UBC TFDP2 CCND1 POLE RPS27A CDK4 E2F1 MYC CDK1 CDKN1A CDKN1B AKT3 CCNA2 CCNA1 CCNE2 CCNE1 POLE4 CDK2 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 CABLES1 PCNA WEE1 CCNH MAX E2F5 MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDK7 CDC6 MNAT1 CDC25A CKS1B GMNN PSMD8 PSMD9 FBXO5 PSMD6 PSMD7 MCM10 PSMD4 TK1 HDAC1 DBF4 PSMD5 TYMS PSMD2 RPA4 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 E2F6 RBL2 PSMA4 RBL1 PSMA1 PSMA2 PSME3 CDC45 PSME1 PSME2 E2F4 PSMD10 PSMD12 PSMD11 DHFR PSMD14 PSMD13 AKT2 PSMA7 PSMB10 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 SIGNALING BY BMP%REACTOME%R-HSA-201451.4 Signaling by BMP ACVR2B SMAD1 ACVR2A SMAD7 SMAD4 SMAD6 SMURF2 CER1 AMHR2 ZFYVE16 GDF2 SMAD9 SMAD5 BMPR1B BMPR1A ACVRL1 BMPR2 NOG GREM2 CHRDL1 BMP2 UBE2D3 SKI AMH FSTL1 BMP10 UBE2D1 SMURF1 INSULIN-LIKE GROWTH FACTOR-2 MRNA BINDING PROTEINS (IGF2BPS IMPS VICKZS) BIND RNA%REACTOME DATABASE ID RELEASE 76%428359 Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs IMPs VICKZs) bind RNA IGF2BP1 IGF2BP3 IGF2BP2 NOTCH3 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013507.1 NOTCH3 Activation and Transmission of Signal to the Nucleus PSEN1 PSENEN JAG2 NEURL1 NCSTN EGF JAG1 UBA52 NEURL1B NOTCH3 EGFR MIB2 MIB1 UBB UBC RPS27A WWP2 PSEN2 YBX1 APH1A APH1B ADAM10 TACC3 DLL1 DLL4 ANDROGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%193048 Androgen biosynthesis SRD5A1 HSD17B3 CYP17A1 POMC HSD17B12 LHB SRD5A3 CGA HSD3B2 SRD5A2 HSD3B1 LYSINE CATABOLISM%REACTOME%R-HSA-71064.2 Lysine catabolism PHYKPL OGDH DLD HYKK AADAT ALDH7A1 GCDH PIPOX SLC25A21 AASS DLST CRYM PERK REGULATES GENE EXPRESSION%REACTOME%R-HSA-381042.1 PERK regulates gene expression NFYA NFYB CCL2 NFYC CXCL8 ASNS HSPA5 KHSRP DIS3 ATF6 EIF2AK3 HERPUD1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 CEBPB EXOSC4 EXOSC9 CEBPG EXOSC8 EXOSC3 IGFBP1 EIF2S2 EXOSC2 EIF2S1 EXOSC1 EIF2S3 DDIT3 ATF3 ATF4 PENTOSE PHOSPHATE PATHWAY DISEASE%REACTOME%R-HSA-6791465.1 Pentose phosphate pathway disease TALDO1 RPIA SEROTONIN AND MELATONIN BIOSYNTHESIS%REACTOME%R-HSA-209931.1 Serotonin and melatonin biosynthesis ASMT AANAT TPH2 DDC TPH1 SIGNALING BY FGFR3 FUSIONS IN CANCER%REACTOME DATABASE ID RELEASE 76%8853334 Signaling by FGFR3 fusions in cancer PIK3R1 HRAS FRS2 GAB1 PIK3CA SOS1 NRAS FGFR3 TRANSCRIPTIONAL REGULATION BY SMALL RNAS%REACTOME%R-HSA-5578749.3 Transcriptional regulation by small RNAs NUP42 NUP43 RAE1 RANBP2 RAN NUP35 NUP37 POLR2A POLR2B AGO1 POLR2C AGO2 POLR2D POLR2E POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 IPO8 H2AC7 SEC13 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 NUP107 NUP188 H2BC11 H3C15 NUP210 NUP93 H2BS1 POM121 NUP205 H2AZ1 H2BC9 H2AZ2 AAAS H4C9 H2BC8 NUP160 H2BC5 POM121C NUP85 H2BC3 TPR NUP88 H2BC1 NUP155 NUP214 NUP153 H2AC20 NUP62 NDC1 TNRC6A NUP133 NUP50 NUP54 APEX1-INDEPENDENT RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-5649702.2 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway LIG3 NEIL2 XRCC1 NEIL1 OGG1 POLB PNKP NUCLEOSOME ASSEMBLY%REACTOME DATABASE ID RELEASE 76%774815 Nucleosome assembly NPM1 H2AX H2AB1 H2AC19 H2AC14 H2BC21 CENPA H2BU1 CENPC HJURP OIP5 H2AC8 H2AC6 CENPT H2AC7 CENPU H2BC17 RSF1 H2BC12 H2BC13 CENPH MIS18BP1 CENPI H2BC14 H2AJ CENPW CENPX CENPK H2BC15 CENPL MIS18A CENPM H2BC11 CENPN CENPO CENPP CENPQ CENPS RBBP4 H2BS1 RBBP7 H2AZ1 H2BC9 ITGB3BP H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 H2AC20 RUVBL1 KNL1 MPS II - HUNTER SYNDROME%REACTOME DATABASE ID RELEASE 76%2206296 MPS II - Hunter syndrome IDS ONCOGENE INDUCED SENESCENCE%REACTOME DATABASE ID RELEASE 76%2559585 Oncogene Induced Senescence TP53 CDKN2A MDM2 ID1 MDM4 ETS1 ETS2 SP1 AGO3 UBA52 AGO4 AGO1 MAPK1 MAPK3 UBB RB1 TFDP1 UBC CDK6 TFDP2 RPS27A CDK4 E2F1 E2F2 E2F3 CDKN2D CDKN2C TNRC6C MOV10 ERF TNRC6A TNRC6B CDKN2B ACYL CHAIN REMODELING OF DAG AND TAG%REACTOME%R-HSA-1482883.3 Acyl chain remodeling of DAG and TAG DGAT1 DGAT2L6 MGLL DGAT2L7P AWAT2 PNPLA3 PNPLA2 DGAT2 CHOLINE CATABOLISM%REACTOME%R-HSA-6798163.2 Choline catabolism CHDH SLC44A1 SARDH BHMT ALDH7A1 DMGDH TICAM1,TRAF6-DEPENDENT INDUCTION OF TAK1 COMPLEX%REACTOME%R-HSA-9014325.3 TICAM1,TRAF6-dependent induction of TAK1 complex TAB1 UBB UBA52 UBC TICAM1 RPS27A TRAF6 TLR3 TAB3 TAB2 MAP3K7 DEFECTIVE ST3GAL3 CAUSES MCT12 AND EIEE15%REACTOME%R-HSA-3656243.1 Defective ST3GAL3 causes MCT12 and EIEE15 ST3GAL3 LUM OMD KERA PRELP ACAN OGN FMOD ACROSOME REACTION AND SPERM:OOCYTE MEMBRANE BINDING%REACTOME DATABASE ID RELEASE 76%1300645 Acrosome Reaction and Sperm:Oocyte Membrane Binding ACR CD9 IZUMO3 IZUMO2 IZUMO4 IZUMO1 VASOPRESSIN REGULATES RENAL WATER HOMEOSTASIS VIA AQUAPORINS%REACTOME DATABASE ID RELEASE 76%432040 Vasopressin regulates renal water homeostasis via Aquaporins GNG3 RAB11A GNG2 PRKACG GNG5 PRKACB AVP GNG4 GNG7 RAB11FIP2 GNG8 ADCY9 PRKAR1B PRKAR1A PRKAR2A GNG10 MYO5B GNAS GNG12 GNG11 PRKAR2B GNG13 GNB2 GNB1 GNB4 ADCY4 GNB3 AVPR2 ADCY3 ADCY2 GNB5 ADCY1 ADCY8 ADCY7 ADCY6 GNGT1 ADCY5 GNGT2 PRKACA AQP4 AQP2 AQP3 AQP1 DOWNREGULATION OF ERBB4 SIGNALING%REACTOME%R-HSA-1253288.3 Downregulation of ERBB4 signaling UBB UBA52 UBC ITCH RPS27A NEDD4 WWP1 SRC SYNTHESIS OF VERY LONG-CHAIN FATTY ACYL-COAS%REACTOME DATABASE ID RELEASE 76%75876 Synthesis of very long-chain fatty acyl-CoAs TECR ELOVL1 ELOVL5 ACSL6 ACSL1 ELOVL2 ACSL5 ELOVL3 ELOVL6 ACSL3 ELOVL4 SLC27A3 ELOVL7 HACD1 HACD3 HACD2 ACSBG1 HACD4 ACSBG2 HSD17B3 HSD17B12 TECRL ACSF3 LRR FLII-INTERACTING PROTEIN 1 (LRRFIP1) ACTIVATES TYPE I IFN PRODUCTION%REACTOME DATABASE ID RELEASE 76%3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production CREBBP IRF3 EP300 LRRFIP1 CTNNB1 DIGESTION AND ABSORPTION%REACTOME%R-HSA-8963743.2 Digestion and absorption GUCY2C SLC5A1 SLC2A5 SI GUCA2B GUCA2A LCT PIR ALPI LIPF PNLIPRP1 PNLIPRP2 CEL PNLIPRP3 SLC2A2 RSC1A1 CLPS PNLIP CHIT1 MGAM CHIA AMY2A AMY1A AMY2B TREH AMY1B AMY1C METABOLISM OF STEROIDS%REACTOME%R-HSA-8957322.2 Metabolism of steroids CREBBP RAN LBR CYP21A2 KPNB1 CYP27B1 CYP11B1 CYP24A1 CYP2R1 LHB SLCO1B1 SEC23A SLCO1B3 LGMN LRP2 CYP17A1 CGA SLCO1A2 SEC24B SEC24A CYP19A1 POMC CYP11A1 SEC24D SEC24C CYP11B2 MSMO1 NSDHL PLPP6 INSIG2 INSIG1 IDI2 ACAT2 EBP SCAP DHCR24 ARV1 HSD17B3 HSD17B12 HSD17B7 GC GPAM PIAS4 IDI1 UBE2I MVK ACACB TM7SF2 VDR PMVK SC5D FDFT1 FDPS NFYA HMGCS1 GGPS1 NFYB NFYC CYP51A1 ELOVL6 RXRA LSS SREBF2 SQLE SUMO2 SCD SP1 MTF1 DHCR7 PPARA HSD17B14 AKR1B1 HSD17B11 AKR1D1 HSD17B1 HSD17B4 HSD17B2 CYP46A1 TSPO STARD3 ABCB11 STARD4 CYP7A1 OSBP SRD5A2 OSBPL9 STARD3NL MVD STARD6 ABCC3 SRD5A1 HSD3B7 ACOT8 STAR OSBPL7 AKR1B15 OSBPL6 PTGIS STARD5 SLC10A1 AKR1C1 OSBPL3 SLC10A2 OSBPL2 TSPOAP1 HSD11B1 AKR1C3 HSD11B2 NR1H4 SERPINA6 AKR1C2 AKR1C4 BAAT CYP7B1 CYP8B1 CYP27A1 CYP39A1 CH25H AMACR FASN ACOX2 FABP6 SRD5A3 OSBPL1A SLC27A2 CUBN SLC27A5 SAR1B MBTPS1 ACACA NCOA1 MED1 ALB NCOA2 SMARCD3 MBTPS2 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X FDXR FDX1 FDX2 HSD3B2 HSD3B1 CAM PATHWAY%REACTOME DATABASE ID RELEASE 76%111997 CaM pathway PRKCG KPNA2 PRKACG PRKACB ADCY9 CAMKK1 PRKAR1B CAMKK2 PRKAR1A PDE1B PDE1A PRKAR2A PRKX PRKCD PRKCA CAMK2B PRKAR2B CAMK2D NBEA CAMK2A PDE1C CAMK2G ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 CAMK4 ADCY6 ADCY5 PRKACA GRK2 CALM1 HISTIDINE CATABOLISM%REACTOME DATABASE ID RELEASE 76%70921 Histidine catabolism CARNS1 FTCD HNMT HAL UROC1 AMDHD1 HDC CARNMT1 ALPHA-LINOLENIC (OMEGA3) AND LINOLEIC (OMEGA6) ACID METABOLISM%REACTOME DATABASE ID RELEASE 76%2046104 alpha-linolenic (omega3) and linoleic (omega6) acid metabolism ABCD1 ACOT8 ELOVL1 FADS2 SCP2 ACAA1 ELOVL5 ACSL1 ELOVL2 ELOVL3 HSD17B4 FADS1 MYD88 DEPENDENT CASCADE INITIATED ON ENDOSOME%REACTOME%R-HSA-975155.3 MyD88 dependent cascade initiated on endosome TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 TLR7 MAPK8 NFKBIB FBXW11 IRAK4 SAA1 MYD88 TICAM2 LY96 TICAM1 CD14 TLR4 IRF7 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 TLR9 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 REGULATION OF GAP JUNCTION ACTIVITY%REACTOME%R-HSA-191650.2 Regulation of gap junction activity TJP1 GJA1 REGULATION OF MITOTIC CELL CYCLE%REACTOME%R-HSA-453276.2 Regulation of mitotic cell cycle CCNA1 CDK2 SKP2 FZR1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 BTRC ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 SKP1 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 FBXO5 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 AURKA PSMB6 PSMB7 PSMB4 CCNB1 PSMB5 PSMB2 UBB RB1 PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 CDC14A PSMB9 RPS27A SEM1 PTTG1 AURKB PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 CDK1 CCNA2 NOTCH3 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%9013508 NOTCH3 Intracellular Domain Regulates Transcription CREBBP HES1 STAT1 EP300 SNW1 HEY1 HEY2 MAML2 MAMLD1 MAML1 RBPJ PLXND1 KAT2B PBX1 KAT2A DLGAP5 NOTCH3 WWC1 MAML3 PTCRA FABP7 NOTCH1 HEYL HES5 GLYCOGEN METABOLISM%REACTOME DATABASE ID RELEASE 76%8982491 Glycogen metabolism PGM2L1 UGP2 AGL NHLRC1 UBA52 GYS1 GYG1 GAA UBB UBC GBE1 RPS27A PHKA1 GYG2 PHKA2 PYGM PGM1 PHKB EPM2A PHKG1 PYGB PHKG2 PYGL GYS2 CALM1 PGM2 PPP1R3C MET ACTIVATES PTPN11%REACTOME DATABASE ID RELEASE 76%8865999 MET activates PTPN11 HGF MET GAB1 PTPN11 SIGNALING BY PDGF%REACTOME DATABASE ID RELEASE 76%186797 Signaling by PDGF COL6A2 COL4A3 COL6A1 PIK3CA COL4A5 PLCG1 SOS1 COL9A1 COL6A3 COL9A3 COL6A6 COL9A2 COL6A5 GRB7 THBS2 THBS1 PDGFB CRKL PDGFRB STAT1 PTPN11 PIK3R1 RAPGEF1 NCK2 FURIN PLG PIK3R2 NCK1 SPP1 CRK STAT6 BCAR1 STAT3 STAT5A STAT5B HRAS PDGFRA PIK3CB RASA1 PTPN12 NRAS PLAT THBS4 THBS3 PDGFD COL4A2 SRC COL4A1 COL4A4 RESISTANCE OF ERBB2 KD MUTANTS TO NERATINIB%REACTOME%R-HSA-9665246.1 Resistance of ERBB2 KD mutants to neratinib HSP90AA1 CDC37 ERBB2 ERBIN LAGGING STRAND SYNTHESIS%REACTOME%R-HSA-69186.2 Lagging Strand Synthesis POLD2 RFC5 RFC3 RFC4 RFC2 PRIM2 LIG1 PRIM1 RFC1 POLA1 POLA2 PCNA RPA1 RPA2 RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 VITAMIN D (CALCIFEROL) METABOLISM%REACTOME DATABASE ID RELEASE 76%196791 Vitamin D (calciferol) metabolism VDR CYP2R1 LGMN LRP2 GC PIAS4 CUBN CYP27B1 UBE2I SUMO2 CYP24A1 CDK-MEDIATED PHOSPHORYLATION AND REMOVAL OF CDC6%REACTOME%R-HSA-69017.2 CDK-mediated phosphorylation and removal of Cdc6 CCNA1 CCNE2 CCNE1 CDK2 FZR1 CDC6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CCNA2 ACTIVATION AND OLIGOMERIZATION OF BAK PROTEIN%REACTOME%R-HSA-111452.2 Activation and oligomerization of BAK protein BAK1 BID SLBP DEPENDENT PROCESSING OF REPLICATION-DEPENDENT HISTONE PRE-MRNAS%REACTOME DATABASE ID RELEASE 76%77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs NCBP2 SNRPG LSM10 LSM11 SNRPE SNRPF SNRPD3 ZNF473 SNRPB SLBP NCBP1 NRAGE SIGNALS DEATH THROUGH JNK%REACTOME%R-HSA-193648.1 NRAGE signals death through JNK BCL2L11 NGF SOS1 GNA13 TRIO RASGRF2 MCF2L VAV3 ARHGEF16 VAV1 ARHGEF40 ARHGEF5 ARHGEF26 PREX1 TIAM2 KALRN OBSCN NGEF MAGED1 ECT2 VAV2 ARHGEF33 TIAM1 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L MAPK8 AATF AKAP13 ABR ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF7 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 MCF2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 BAD PLEKHG5 RAC1 ARHGEF18 ITSN1 NGFR DEFECTIVE OGG1 SUBSTRATE BINDING%REACTOME DATABASE ID RELEASE 76%9656255 Defective OGG1 Substrate Binding OGG1 TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING%REACTOME%R-HSA-975110.2 TRAF6 mediated IRF7 activation in TLR7 8 or 9 signaling IRAK4 UBE2V1 MYD88 IRAK1 TLR9 TLR7 TRAF6 IRF7 UBE2N ESTROGEN BIOSYNTHESIS%REACTOME%R-HSA-193144.5 Estrogen biosynthesis AKR1B15 HSD17B14 CYP19A1 HSD17B11 HSD17B1 HSD17B2 IKK COMPLEX RECRUITMENT MEDIATED BY RIP1%REACTOME DATABASE ID RELEASE 76%937041 IKK complex recruitment mediated by RIP1 UBB UBE2V1 IKBKB TICAM2 CHUK UBC LY96 UBE2D2 UBE2D3 TICAM1 RPS27A IKBKG CD14 TLR4 RIPK1 BIRC2 UBE2D1 UBA52 BIRC3 RIPK3 TRAF6 UBE2N NEPHRIN FAMILY INTERACTIONS%REACTOME DATABASE ID RELEASE 76%373753 Nephrin family interactions MAGI2 CD2AP NPHS1 ACTN4 ACTN1 PIK3CB PIK3CA ACTN3 WASL PIK3R1 ACTN2 IQGAP1 FYN CASK NCK2 SPTAN1 KIRREL3 PIK3R2 KIRREL1 SPTBN1 KIRREL2 NCK1 SIGNALING BY ERBB2 ECD MUTANTS%REACTOME%R-HSA-9665348.2 Signaling by ERBB2 ECD mutants HSP90AA1 CDC37 HRAS ERBB2 ERBIN SHC1 GAB1 PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 EGFR P38MAPK EVENTS%REACTOME%R-HSA-171007.3 p38MAPK events MAPK12 MAPK13 MAPKAPK3 HRAS MAPKAPK2 MAPK14 MAPK11 RALGDS RALA RALB NRAS NOTCH4 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-9013700.1 NOTCH4 Activation and Transmission of Signal to the Nucleus JAG1 PSEN1 PSENEN YWHAZ ADAM10 NCSTN NOTCH4 PSEN2 APH1A DLL4 APH1B SYNTHESIS OF EPOXY (EET) AND DIHYDROXYEICOSATRIENOIC ACIDS (DHET)%REACTOME DATABASE ID RELEASE 76%2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) EPHX2 CYP2C9 CYP2C8 CYP1A2 CYP1B1 CYP2C19 CYP2J2 CYP1A1 LIGAND-INDEPENDENT CASPASE ACTIVATION VIA DCC%REACTOME DATABASE ID RELEASE 76%418889 Ligand-independent caspase activation via DCC DAPK1 DAPK2 DAPK3 CASP9 MAGED1 CASP3 APPL1 UNC5A UNC5B DCC VPU MEDIATED DEGRADATION OF CD4%REACTOME%R-HSA-180534.1 Vpu mediated degradation of CD4 vpu CD4 BTRC SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DEADENYLATION OF MRNA%REACTOME DATABASE ID RELEASE 76%429947 Deadenylation of mRNA CNOT8 CNOT9 TUT7 EIF4A2 TUT4 EIF4A1 TNKS1BP1 CNOT6L PAIP1 EIF4A3 PAN2 PAN3 EIF4E EIF4B PABPC1 PARN CNOT10 CNOT4 CNOT6 CNOT7 EIF4G1 CNOT1 CNOT11 CNOT2 CNOT3 DEFECTIVE AHCY CAUSES HMAHCHD%REACTOME DATABASE ID RELEASE 76%5578997 Defective AHCY causes HMAHCHD AHCY DEFECTIVE MPI CAUSES MPI-CDG (CDG-1B)%REACTOME DATABASE ID RELEASE 76%4043916 Defective MPI causes MPI-CDG (CDG-1b) MPI DAG AND IP3 SIGNALING%REACTOME DATABASE ID RELEASE 76%1489509 DAG and IP3 signaling PRKCG KPNA2 PLCG1 PRKACG PRKACB ADCY9 CAMKK1 PRKAR1B CAMKK2 PRKAR1A PDE1B PDE1A PRKAR2A AHCYL1 ITPR1 ITPR2 ITPR3 PRKX PRKCD PRKCA CAMK2B PRKAR2B CAMK2D NBEA CAMK2A PRKCE PDE1C CAMK2G ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 CAMK4 ADCY6 ADCY5 PRKACA GRK2 CALM1 FLT3 SIGNALING BY CBL MUTANTS%REACTOME DATABASE ID RELEASE 76%9706377 FLT3 signaling by CBL mutants UBB UBA52 FLT3LG UBC RPS27A FLT3 CBL PRESYNAPTIC DEPOLARIZATION AND CALCIUM CHANNEL OPENING%REACTOME DATABASE ID RELEASE 76%112308 Presynaptic depolarization and calcium channel opening CACNA1B CACNA1A CACNA2D1 CACNA1E CACNA2D3 CACNB1 CACNB2 CACNA2D2 CACNG2 CACNB3 CACNB4 CACNG4 CLASSICAL KIR CHANNELS%REACTOME DATABASE ID RELEASE 76%1296053 Classical Kir channels KCNJ2 KCNJ4 KCNJ12 KCNJ14 BUDDING%REACTOME%R-HSA-168302.3 Budding PA PB2 NP NA NS HA M PB1 G ALPHA (Z) SIGNALLING EVENTS%REACTOME DATABASE ID RELEASE 76%418597 G alpha (z) signalling events PRKCB GNAZ PRKCG GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 RGSL1 ADCY9 RGS4 GNG10 GNAI3 GNAS PRKCD GNG12 GNAI1 PRKCA GNG11 GNAI2 GNG13 GNAT3 GNB2 GNB1 PRKCE RGS17 GNB4 RGS19 ADCY4 GNB3 RGS16 ADCY3 ADCY2 GNB5 ADCY1 RGS20 ADCY8 ADRA2C ADCY7 ADCY6 GNGT1 ADRA2B ADCY5 PRKCH ADRA2A GNGT2 PRKCQ COLLAGEN DEGRADATION%REACTOME DATABASE ID RELEASE 76%1442490 Collagen degradation COL26A1 ELANE COL9A1 COL9A3 COL9A2 COL18A1 COL14A1 MMP20 CTSL CTSK COL16A1 COL12A1 CTSD CTSB MMP7 MMP1 COL25A1 MMP2 MMP3 MMP8 MMP9 MMP10 MMP12 PRSS2 MMP11 MMP14 PHYKPL MMP13 MMP15 COL23A1 ADAM10 MMP19 COL15A1 ADAM17 TMPRSS6 FURIN ADAM9 COL17A1 COL19A1 COL13A1 GLUCAGON SIGNALING IN METABOLIC REGULATION%REACTOME%R-HSA-163359.2 Glucagon signaling in metabolic regulation GNG3 GNG2 PRKACG GNG5 PRKACB GNG4 GNG7 GNG8 ADCY9 PRKAR1B CYSLTR2 PRKAR1A PRKAR2A GNG10 GNAS GNG12 GNG11 PRKAR2B GNG13 GNB2 GNB1 GNB4 ADCY4 GNB3 ADCY3 ADCY2 ADCY1 ADCY8 GCG ADCY7 ADCY6 ADCY5 PRKACA INTERLEUKIN-7 SIGNALING%REACTOME DATABASE ID RELEASE 76%1266695 Interleukin-7 signaling STAT5A STAT5B TSLP IRS1 HGF IL2RG IL7 H3C15 CRLF2 IRS2 H3C8 RAG2 CISH RAG1 PIK3R1 PIK3R3 JAK3 STAT3 SOCS1 SOCS2 BRWD1 JAK1 PIK3R2 SMARCA4 BIOSYNTHESIS OF SPECIALIZED PRORESOLVING MEDIATORS (SPMS)%REACTOME DATABASE ID RELEASE 76%9018678 Biosynthesis of specialized proresolving mediators (SPMs) ALOX5 EPHX2 PTGS2 HPGD PTGR1 LTA4H GSTM4 CYP2C9 ALOX15 CYP2C8 ALOX12 CYP2D6 CYP1A2 CYP2E1 CYP3A4 LTC4S ALOX5AP CYP1A1 SUNITINIB-RESISTANT KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9669934 Sunitinib-resistant KIT mutants KIT SLC TRANSPORTER DISORDERS%REACTOME%R-HSA-5619102.6 SLC transporter disorders SLC3A2 SLC3A1 AVPR1A NUP42 NUP43 RAE1 RANBP2 SLC12A3 SLC16A1 AVP SLC12A1 GCK NUP35 RHAG NUP37 SLC24A1 SLC24A4 SLC6A20 AVPR2 SEC13 NUP107 NUP188 SLC4A1 SLCO1B1 SLC4A4 SLC12A6 SLC39A4 SLCO1B3 SLC34A3 SLC34A2 SLC35A2 SLC35A1 SLC6A19 SLC35A3 SLC6A18 SLC35C1 NUP210 SLC33A1 SLC6A14 SLC11A2 NUP93 SLC5A7 SLCO2A1 POM121 NUP205 SLC1A1 SLC1A3 SLC5A1 AAAS SLC9A6 SLC29A3 SLC5A2 NUP160 SLC27A4 POM121C SLC9A9 NUP85 TPR NUP88 GCKR NUP155 NUP214 NUP153 CP SLC2A9 SLC6A5 SLC5A5 SLC26A4 SLC26A3 SLC2A1 SLC40A1 SLC2A2 BSG SLC34A1 SLC6A2 SLC6A3 HK1 SLC22A12 SLC22A5 HEPH SLC22A18 NUP62 NDC1 SLC36A2 SLC26A2 NUP133 SLC17A5 SLC2A10 SLC17A8 SLC7A7 SLC7A9 NUP50 AVPR1B NUP54 SLC20A2 SEMAXANIB-RESISTANT FLT3 MUTANTS%REACTOME%R-HSA-9702577.1 semaxanib-resistant FLT3 mutants FLT3 TRANSLATION OF STRUCTURAL PROTEINS%REACTOME DATABASE ID RELEASE 76%9683701 Translation of structural proteins ST3GAL3 3a SUMO1 GALNT1 PARP10 PARP6 GSK3B PARP4 PARP16 PARP9 UBA52 PARP14 N PARP8 ST6GALNAC2 PRKCSH E GANAB S UBB ST3GAL4 MGAT1 UBC ST3GAL1 ST3GAL2 ST6GAL1 RPS27A M MOGS CANX ST6GALNAC3 ST6GALNAC4 UBE2I NOTCH-HLH TRANSCRIPTION PATHWAY%REACTOME%R-HSA-350054.3 Notch-HLH transcription pathway HDAC3 CREBBP HDAC2 HDAC1 HDAC6 SNW1 MAMLD1 NOTCH2 NOTCH3 NOTCH4 TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 HDAC11 KAT2B KAT2A HDAC5 HDAC8 HDAC9 MAML3 HDAC4 NOTCH1 HDAC7 ZINC TRANSPORTERS%REACTOME%R-HSA-435354.2 Zinc transporters SLC39A10 SLC39A1 SLC39A14 SLC39A3 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC30A1 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 PTK6 REGULATES CELL CYCLE%REACTOME DATABASE ID RELEASE 76%8849470 PTK6 Regulates Cell Cycle PTK6 CCNE1 CDK2 CCND1 CDK4 CDKN1B RAS SIGNALING DOWNSTREAM OF NF1 LOSS-OF-FUNCTION VARIANTS%REACTOME%R-HSA-6802953.1 RAS signaling downstream of NF1 loss-of-function variants SPRED3 SPRED2 SPRED1 HRAS NRAS NF1 CALCINEURIN ACTIVATES NFAT%REACTOME%R-HSA-2025928.2 Calcineurin activates NFAT NFATC2 PPP3R1 CALM1 PPIA FKBP1A PPP3CA NFATC3 PPP3CB NFATC1 VRNA SYNTHESIS%REACTOME%R-HSA-192814.3 vRNA Synthesis PA PB2 NP PB1 PARP1 TOXICITY OF BOTULINUM TOXIN TYPE A (BOTA)%REACTOME DATABASE ID RELEASE 76%5250968 Toxicity of botulinum toxin type A (botA) HA-33 SNAP25 ha70 ntnha botA SV2C SV2B SV2A ha17 EGFR TRANSACTIVATION BY GASTRIN%REACTOME%R-HSA-2179392.1 EGFR Transactivation by Gastrin PRKCA HBEGF HRAS MMP3 EGFR SOS1 NRAS DRUG-MEDIATED INHIBITION OF ERBB2 SIGNALING%REACTOME DATABASE ID RELEASE 76%9652282 Drug-mediated inhibition of ERBB2 signaling HSP90AA1 CDC37 ERBB2 ERBIN TICAM1 DEFICIENCY - HSE%REACTOME DATABASE ID RELEASE 76%5602566 TICAM1 deficiency - HSE TICAM1 TLR3 ACYL CHAIN REMODELING OF CL%REACTOME%R-HSA-1482798.2 Acyl chain remodeling of CL PLA2G6 LCLAT1 HADHB HADHA TAZ PLA2G4A DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL1%REACTOME%R-HSA-9616334.2 Defective Base Excision Repair Associated with NEIL1 NEIL1 DERMATAN SULFATE BIOSYNTHESIS%REACTOME%R-HSA-2022923.1 Dermatan sulfate biosynthesis CHST14 CSPG5 CSPG4 BCAN NCAN DSE DCN DSEL BGN VCAN UST DEFECTIVE SLC39A4 CAUSES ACRODERMATITIS ENTEROPATHICA, ZINC-DEFICIENCY TYPE (AEZ)%REACTOME%R-HSA-5619088.2 Defective SLC39A4 causes acrodermatitis enteropathica, zinc-deficiency type (AEZ) SLC39A4 PLATELET ACTIVATION, SIGNALING AND AGGREGATION%REACTOME%R-HSA-76002.3 Platelet activation, signaling and aggregation PRKCB FN1 ACTN1 F8 GNA13 AAMP VCL SYK APBB1IP FYN MAPK1 MAPK3 GAS6 GNAI3 PDGFB ARRB1 GNAI1 ARRB2 GNAI2 HGF A1BG ADRA2C SERPINA3 VAV2 ADRA2B ADRA2A ABCC4 PIK3R2 POTEKP ISLR HABP4 FAM3C CHID1 SERPINF2 PRKCG ACTN4 GTPBP2 SYTL4 P2RY1 TMX3 CD109 SELENOP TAGLN2 NHLRC2 TEX264 STXBP2 TUBA4A ENDOD1 APOH VTI1B ITGA2B RARRES2 CYRIB MANF LAMP2 SELP SCCPDH MAGED2 HRG FERMT3 LGALS3BP ECM1 WDR1 PLEK OLA1 CTSW SERPINA4 TMSB4X TIMP3 PHACTR2 SRGN ANXA5 MMRN1 TOR4A ITIH4 ITIH3 CLEC3B CDC37L1 LY6G6F LHFPL2 PCYOX1L ITGB3 RAC1 SRC SERPINE1 STXBP3 A2M TTN LCK TLN1 PFN1 ACTN2 ORM1 RAB27B ORM2 TF TIMP1 FCER1G CAP1 MPL THPO LCP2 ALDOA CD63 PLG PROS1 F13A1 APOA1 FGB FGA APLP2 PPIA VWF GP1BB SCG3 FGG GP1BA GP5 F5 CLU GP9 CD9 APOOL SERPING1 CALU QSOX1 AHSG ALB PIK3CB PRKCE RASGRP2 RASGRP1 RAP1B RAP1A RAF1 RAPGEF3 RAPGEF4 SPP2 TRPC7 LEFTY2 TRPC6 TRPC3 PLA2G4A BRPF3 APP PECAM1 VAV3 THBS1 RHOG VAV1 ITPR1 GNG10 ITPR2 ITPR3 CYB5R1 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 PDPK1 GNB3 FLNA PTPN11 GNB5 SOD1 PIK3R1 GNGT1 PDPN MPIG6B GP6 GNGT2 LAT CDC42 PTPN6 CALM1 GNA14 GNG3 GNA15 GNG2 EGF GNG5 GNG4 GNG7 GNA11 GNG8 PPBP AKT1 CFL1 LYN PRKCD PRKCA PTK2 YWHAZ CSK VEGFB VEGFC PCDH7 VEGFD VEGFA DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ MAPK14 DGKQ PRKCQ CLEC1B DAGLB DGKK DGKI DGKH TGFB2 TGFB3 MGLL F2 SHC1 PIK3CA SOS1 HSPA5 RHOB GNA12 CD36 PIK3R6 PIK3CG PIK3R5 SERPINA1 P2RY12 IGF1 IGF2 F2RL2 PF4 F2RL3 CRK PTPN1 BCAR1 F2R STX4 GNAT3 KNG1 CFD RAC2 TBXA2R SPARC TGFB1 PIK3R3 PSAP PRKCZ RHOA PLCG2 TP53 REGULATES TRANSCRIPTION OF CELL DEATH GENES%REACTOME DATABASE ID RELEASE 76%5633008 TP53 Regulates Transcription of Cell Death Genes CREBBP CASP2 TP53 TRIAP1 PIDD1 CASP6 BBC3 CASP1 TP53BP2 AIFM2 APAF1 FAS ATM RABGGTB RABGGTA TMEM219 BIRC5 NLRC4 TP73 PERP BID BAX PPP1R13B STEAP3 TNFRSF10B TNFRSF10A TNFRSF10D BNIP3L IGFBP3 CASP10 NDRG1 PMAIP1 TP53INP1 BCL2L14 ZNF420 TNFRSF10C CHM TP53AIP1 TP53I3 BCL6 TP63 PRELID3A PRELID1 CRADD ACTIVATION OF THE MRNA UPON BINDING OF THE CAP-BINDING COMPLEX AND EIFS, AND SUBSEQUENT BINDING TO 43S%REACTOME DATABASE ID RELEASE 76%72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 FAU RPS21 RPS24 RPS23 EIF4H EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 RPS4X RPS15 EIF4A1 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 EIF4EBP1 RPS7 EIF4E EIF4B RPS8 RPS5 RPS6 RPSA PABPC1 RPS3A RPS27A RPS4Y2 RPS27L RPS4Y1 EIF4G1 RPS15A RPS3 RPS2 LXRS REGULATE GENE EXPRESSION TO LIMIT CHOLESTEROL UPTAKE%REACTOME DATABASE ID RELEASE 76%9031525 LXRs regulate gene expression to limit cholesterol uptake NR1H2 RXRA MYLIP RXRB NR1H3 TYPE II NA+ PI COTRANSPORTERS%REACTOME DATABASE ID RELEASE 76%427589 Type II Na+ Pi cotransporters SLC34A3 SLC34A2 SLC34A1 TRANSLESION SYNTHESIS BY Y FAMILY DNA POLYMERASES BYPASSES LESIONS ON DNA TEMPLATE%REACTOME DATABASE ID RELEASE 76%110313 Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template POLD2 REV3L RCHY1 POLE4 PCLAF USP43 POLE2 POLE3 VCP PCNA UBA52 USP10 UFD1 UBB RFC5 UBC RFC3 UBA7 POLK RFC4 POLI RFC2 TRIM25 RPS27A POLE UBE2L6 RFC1 NPLOC4 SPRTN ISG15 RPA1 RPA2 RPA3 POLD3 POLH POLD4 REV1 POLD1 MAD2L2 CELL-CELL COMMUNICATION%REACTOME%R-HSA-1500931.4 Cell-Cell communication ACTN1 ITGB1 JUP FYN CLDN5 ANG FLNA PTPN11 WASL PIK3R1 IQGAP1 NCK2 PTPN6 SPTAN1 PIK3R2 SPTBN1 NCK1 DST ACTN4 CDH5 PTK2B TESK1 PARVB RSU1 FERMT2 ILK LIMS1 PARVA SKAP2 PTK2 CDH1 ACTN3 CADM3 CADM1 NECTIN4 NECTIN3 PVR NECTIN2 NECTIN1 COL17A1 KIRREL3 KIRREL1 KIRREL2 MAGI2 CD2AP NPHS1 PATJ CTNNA1 CLDN2 PIK3CA CLDN1 CDH9 CTNNB1 CDH8 CDH7 CDH6 CDH3 CLDN6 LAMC2 CLDN4 CLDN3 ACTN2 CLDN9 CLDN8 CLDN7 FBLIM1 CDH24 CASK CADM2 SDK1 VASP SDK2 CLDN22 CLDN20 PRKCI CLDN23 CLDN11 CLDN10 CLDN15 CLDN14 CDH10 CLDN12 CDH11 CLDN19 CDH12 CLDN18 CDH13 CLDN17 CLDN16 CD47 CDH17 CDH18 PARD6G PARD6B CTNND1 FLNC MPP5 CDH4 LIMS2 CRB3 TYROBP LAMA3 CDH15 SIRPA LAMB3 CDH2 PXN SIRPG ARHGEF6 SIRPB1 PIK3CB ITGB4 ITGA6 PLEC CD151 FYB1 F11R PARD6A PARD3 MITOCHONDRIAL ABC TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%1369007 Mitochondrial ABC transporters ABCB7 ABCB8 ABCB10 ABCB6 DEFECTIVE ALG3 CAUSES ALG3-CDG (CDG-1D)%REACTOME DATABASE ID RELEASE 76%4720475 Defective ALG3 causes ALG3-CDG (CDG-1d) ALG3 DAP12 INTERACTIONS%REACTOME DATABASE ID RELEASE 76%2172127 DAP12 interactions KLRK1 KIR3DS1 NCR2 PIK3CA PLCG1 KIR2DS2 KIR2DS4 SOS1 B2M KIR2DS5 GRAP2 CD300LB SIGLEC14 TREM1 LCK SIGLEC16 CLEC5A SIGLEC15 SYK CD300E FYN KLRC2 VAV3 BTK KLRD1 SIRPB1 HLA-B HLA-C HLA-E HRAS PIK3CB LCP2 NRAS TREM2 RAC1 PIK3R1 VAV2 TYROBP PIK3R2 PLCG2 INVADOPODIA FORMATION%REACTOME DATABASE ID RELEASE 76%8941237 Invadopodia formation ADAM15 ADAM19 SH3PXD2A ADAM12 NEUROTRANSMITTER UPTAKE AND METABOLISM IN GLIAL CELLS%REACTOME DATABASE ID RELEASE 76%112313 Neurotransmitter uptake and metabolism In glial cells SLC1A2 SLC1A3 SLC38A1 GLUL REGULATION OF TNFR1 SIGNALING%REACTOME DATABASE ID RELEASE 76%5357905 Regulation of TNFR1 signaling RACK1 TNFRSF1A TRAF1 CASP8 TRADD RIPK1 TRAF2 FADD BIRC2 UBA52 BIRC3 RNF31 XIAP SPPL2B SPPL2A TNF UL36 USP21 USP4 USP2 OTULIN UBB CLIP3 IKBKB UBC CHUK RBCK1 RPS27A IKBKG TNFAIP3 SHARPIN CRMA CYLD TAX1BP1 SPI-2 OTUD7B DEFECTIVE ALG12 CAUSES ALG12-CDG (CDG-1G)%REACTOME DATABASE ID RELEASE 76%4720489 Defective ALG12 causes ALG12-CDG (CDG-1g) ALG12 MYD88 CASCADE INITIATED ON PLASMA MEMBRANE%REACTOME%R-HSA-975871.1 MyD88 cascade initiated on plasma membrane TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 NFKBIB fliC TLR10 FBXW11 IRAK4 TLR5 SAA1 MYD88 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 FORMATION OF HIV-1 ELONGATION COMPLEX CONTAINING HIV-1 TAT%REACTOME%R-HSA-167200.3 Formation of HIV-1 elongation complex containing HIV-1 Tat CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TCEA1 SUMOYLATION OF CHROMATIN ORGANIZATION PROTEINS%REACTOME%R-HSA-4551638.5 SUMOylation of chromatin organization proteins CBX8 NUP42 CBX4 PIAS1 NUP43 CBX2 RAE1 RANBP2 BMI1 SUMO1 SUMO3 SUMO2 SATB2 NUP35 NUP37 CHD3 RNF2 SEC13 NUP107 NUP188 HDAC2 HDAC1 NUP210 PHC2 CBX5 NUP93 PHC1 RING1 POM121 NUP205 ZBED1 AAAS H4C9 PHC3 NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP214 NUP153 SUZ12 NUP62 L3MBTL2 SATB1 NDC1 NUP133 PCGF2 NUP50 HDAC4 NUP54 UBE2I INTERLEUKIN-27 SIGNALING%REACTOME DATABASE ID RELEASE 76%9020956 Interleukin-27 signaling STAT1 JAK2 IL27 IL27RA STAT3 IL6ST EBI3 JAK1 TYK2 CANX CRLF1 KSRP (KHSRP) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 76%450604 KSRP (KHSRP) binds and destabilizes mRNA DIS3 YWHAZ DCP2 PARN EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 MAPK14 MAPK11 KHSRP AKT1 COPI-MEDIATED ANTEROGRADE TRANSPORT%REACTOME%R-HSA-6807878.1 COPI-mediated anterograde transport KDELR3 SPTBN4 SPTBN5 DYNC1LI1 DYNC1LI2 TMEM115 SPTBN2 CAPZA1 COPE CAPZA2 ARF3 TMED3 TMED2 GORASP1 ARF4 TMED7 ARF1 ACTR1A TMED9 ARFGAP3 SPTB DCTN6 ARFGAP1 DCTN5 BET1L ARFGAP2 NAPA DCTN1 NAPB GOSR2 DCTN4 GOSR1 SPTAN1 DYNLL2 RAB1A INS SPTBN1 COPZ2 NAPG RAB1B COPZ1 CD59 DYNC1I1 CD55 GBF1 DYNLL1 YKT6 CAPZA3 ARF5 COPG2 COPG1 USO1 ACTR10 DYNC1I2 DCTN2 DCTN3 FOLR1 BET1 KDELR1 STX5 GOLGA2 ARCN1 NSF CAPZB COG8 COG7 COG6 DYNC1H1 COG5 COG4 COG3 COPB2 COPA COG2 TMED10 COG1 ANK2 COPB1 ANK3 SPTA1 ANK1 KDELR2 PTK6 EXPRESSION%REACTOME DATABASE ID RELEASE 76%8849473 PTK6 Expression PTK6 PELP1 NR3C1 EPAS1 HIF1A NITRIC OXIDE STIMULATES GUANYLATE CYCLASE%REACTOME%R-HSA-392154.1 Nitric oxide stimulates guanylate cyclase NOS2 PDE11A KCNMB1 KCNMB2 KCNMB3 PRKG2 KCNMB4 NOS1 GUCY1A2 NOS3 GUCY1A1 PDE2A IRAG1 KCNMA1 PDE10A PDE9A PDE1B PDE5A PDE1A ITPR1 GUCY1B2 GUCY1B1 DOWNSTREAM SIGNALING OF ACTIVATED FGFR1%REACTOME DATABASE ID RELEASE 76%5654687 Downstream signaling of activated FGFR1 HRAS FLRT3 GAB1 FGF1 FGF2 PIK3CA FGF3 PLCG1 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF9 FGF20 FGF23 PIK3R1 FGF22 FLRT2 FLRT1 FRS2 FGF10 PHOSPHORYLATION OF PROTEINS INVOLVED IN THE G2 M TRANSITION BY CYCLIN A:CDC2 COMPLEXES%REACTOME%R-HSA-170145.2 Phosphorylation of proteins involved in the G2 M transition by Cyclin A:Cdc2 complexes CCNA1 CDK1 CCNA2 PROTEIN-PROTEIN INTERACTIONS AT SYNAPSES%REACTOME DATABASE ID RELEASE 76%6794362 Protein-protein interactions at synapses RTN3 PTPRS PTPRF SYT2 SYT1 LRFN3 PTPRD LRFN2 LRFN4 LRFN1 SYT9 IL1RAPL1 HOMER3 EPB41 GRIN2B STXBP1 GRIN1 CASK EPB41L5 GRIN2D EPB41L2 DLG1 LIN7A DLG2 LIN7C HOMER1 DLG3 FLOT1 HOMER2 LIN7B PPFIBP1 DLG4 NTRK3 PPFIBP2 GRIN2A GRIA3 EPB41L1 GRIA4 EPB41L3 GRIN2C SIPA1L1 DLGAP1 APBA1 DLGAP3 DLGAP2 DLGAP4 PPFIA1 STX1A BEGAIN PPFIA4 PPFIA3 PPFIA2 SHARPIN APBA3 APBA2 SLITRK3 LRRC4B SYT7 LRRTM3 SLITRK5 GRM1 LRRTM4 LRRTM1 LRRTM2 GRM5 IL1RAPL2 SHANK2 SHANK1 NLGN3 SHANK3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 SLITRK2 SLITRK1 FLOT2 SLITRK4 SLITRK6 PDLIM5 NLGN4Y NLGN4X SYT12 SYT10 DBNL GRIA1 CRNA SYNTHESIS%REACTOME%R-HSA-192869.3 cRNA Synthesis PA PB2 NP PB1 NEGATIVE REGULATION OF FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654733 Negative regulation of FGFR4 signaling BRAF MKNK1 SPRY2 UBA52 MAPK1 MAPK3 PPP2CA PPP2CB UBB KLB UBC FGF1 RPS27A FGF2 FGF4 FGF6 PTPN11 FGF9 FGF20 PPP2R1A FGF23 FRS2 FGF16 FGF19 FGF18 CBL FGFR4 INTERLEUKIN-1 SIGNALING%REACTOME DATABASE ID RELEASE 76%9020702 Interleukin-1 signaling TAB1 UBE2V1 MAP2K6 APP IL1A IL1B TOLLIP BTRC NFKB1 NKIRAS1 SKP1 NKIRAS2 NFKBIB FBXW11 UBA52 MAP2K1 CUL1 UBB UBC RPS27A RBX1 HMGB1 PELI1 SQSTM1 IL1RN IL1R2 MAP3K3 IL1R1 PSMD8 PSMD9 PSMD6 IRAK4 PSMD7 SAA1 PSMD4 MYD88 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 MAP3K8 PSMB4 PSMB5 MAP2K4 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 CHUK TNIP2 NFKBIA IRAK3 PSMB8 PELI3 RELA PSMB9 SEM1 PELI2 NFKB2 IKBKG PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOD1 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 RUNX3 REGULATES NOTCH SIGNALING%REACTOME DATABASE ID RELEASE 76%8941856 RUNX3 regulates NOTCH signaling CREBBP HES1 EP300 SNW1 MAML2 MAMLD1 MAML1 RBPJ JAG1 KAT2B KAT2A RUNX3 MAML3 NOTCH1 HIV TRANSCRIPTION INITIATION%REACTOME%R-HSA-167161.2 HIV Transcription Initiation GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 ION INFLUX EFFLUX AT HOST-PATHOGEN INTERFACE%REACTOME DATABASE ID RELEASE 76%6803544 Ion influx efflux at host-pathogen interface SLC11A1 PDZD11 ATP7A ATOX1 CASPASE ACTIVATION VIA EXTRINSIC APOPTOTIC SIGNALLING PATHWAY%REACTOME DATABASE ID RELEASE 76%5357769 Caspase activation via extrinsic apoptotic signalling pathway MC159L ORF71 TICAM2 LY96 FASLG TICAM1 FAS CD14 TLR4 CASP8 TRADD RIPK1 TRAF2 FADD CASP3 TNFSF10 TNFRSF10B TNFRSF10A DAPK1 DAPK2 DAPK3 CASP9 MAGED1 APPL1 UNC5A UNC5B DCC ENTRY OF INFLUENZA VIRION INTO HOST CELL VIA ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 76%168275 Entry of Influenza Virion into Host Cell via Endocytosis CLTC PA PB2 NP NA NS HA M PB1 CLTA CELLULAR RESPONSES TO STRESS%REACTOME%R-HSA-2262752.7 Cellular responses to stress CREBBP NOX4 TXNRD1 ATP6V1H MAPK1 IL1A MAPK3 HSP90AA1 YWHAE ACTR1A RPL4 RPL5 RPL30 RPL3 SKP1 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 DYNLL1 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 AJUBA MAFK RPS11 RPL39 NLRP3 RPS10 RPS13 DYNC1I2 RPS12 DCTN2 RPS9 DCTN3 RPS7 CUL1 RPL21 IL6 RPS8 RPS5 UBB RPL23 RPL22 HBB RPS6 RPL13A UBC RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 CAPZB SIN3A RPL26 RPL29 DYNC1H1 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RORA RPL39L RPL41 NR3C1 RPL35A RPL23A RPL3L NR3C2 ELOB RPS26 ELOC RPS25 RPS28 AR RPS27 RPS29 RXRA RPL27A RPL22L1 IFNB1 RPS20 FAU RPS21 PGR RPL26L1 PPARA RPS24 RPS23 CAPZA1 CAPZA2 H2AX EHMT2 H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 FBXL17 H2AC8 BACH1 H2AC6 ANAPC15 H2AC7 ANAPC16 ANAPC7 H2BC17 CITED2 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 ANAPC10 H2BC14 ANAPC11 H2AJ CAT CDC23 UBE2S H2BC15 CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 APOA1 PSMD7 PSMD4 PSMD5 PSMD2 H3C15 PSMD3 NUP210 PSMD1 PSMA5 RBBP4 NUP93 PSMA6 PSMA3 H2BS1 VCP POM121 PSMA4 RBBP7 NUP205 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 IGFBP7 H2AZ2 PSMD10 AAAS H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 POM121C PSMD14 NUP85 H2BC3 PSMD13 TPR NUP88 PSMA7 H2BC1 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 H2AC20 PSMB4 NUP153 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 ALB PSMB8 P4HB PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NUP62 NDC1 NUP133 NUP50 NUP54 HDAC3 NUP42 NUP43 RAE1 RANBP2 NUP35 GPX2 CSNK2A1 GPX1 NUP37 CSNK2A2 CSNK2B HMOX2 ACD TINF2 TERF1 TERF2 H3-4 POT1 TERF2IP NFKB1 HSP90AB1 STIP1 DNAJB1 HSPA1L PTGES3 HSPA2 DNAJA1 DNAJA4 DNAJA2 FKBP4 HSPA1B FKBP5 RING1 STAT3 VEGFA FABP1 TCIRG1 DYNC1LI1 DYNC1LI2 AGO3 AGO4 AGO1 SKP2 FZR1 SLC46A1 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 FLCN SESN1 C12orf66 SZT2 MIOS ITFG2 ATP6V0D1 KPTN ATP6V0D2 DEPDC5 SEH1L LY96 NPRL2 NPRL3 WDR24 SH3BP4 FNIP1 EPAS1 TLR4 FNIP2 HIF1A WDR59 CASTOR1 CASTOR2 STAP2 BMT2 ATP6V1C1 ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR H1-1 H1-0 RRAGA H1-3 H1-2 RRAGC H1-5 RHEB H1-4 RRAGB AKT1S1 RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 ATP6V0B LAMTOR5 HBA2 ATP6V0C ATP6V1G3 ATP6V0E2 BMI1 CXCL8 NCF1 NCF2 MEF2C NCF4 RPS6KA3 RPS6KA2 RPS6KA1 ATP6V1A ATP6V1D ATP6V1F CYBB RNF2 PPP1R15A CYBA CEBPB EIF2AK1 CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 GRB10 TRIB3 CHAC1 ATF5 ATF3 ATF4 ABCC1 HSBP1 HSF1 HDAC6 ATP6V1B2 ATP6V1B1 PHC2 PHC1 PHC3 RB1 TFDP1 CDK6 TFDP2 CDK4 E2F1 E2F2 E2F3 CDKN2B ATF2 CRTC2 CRTC3 CRTC1 SIRT1 CLOCK NPAS2 ARNTL RAI1 NRIP1 MEF2D PPARGC1A NR1D1 UBE2D2 UBE2D3 BAG4 SEC13 DYNC1I1 CAPZA3 ACTR10 ATP7A MAP2K3 MAP2K4 NCOA1 MED1 MAPKAPK3 MAP2K7 NCOA2 SMARCD3 CHD9 NCOA6 MAPK9 HELZ2 TBL1XR1 MAPK10 TGS1 CARM1 TBL1X MRE11 EEF1A1 EHMT1 VENTX KAT5 NBN MAPKAPK5 KEAP1 CBX8 CBX6 CBX4 CBX2 MAP2K6 ATR ERO1A ATOX1 NUDT2 PRDX3 PRDX6 NOX5 NFE2L2 GPX3 GPX6 GPX5 HSPA8 GPX8 APOB GPX7 BLVRB BLVRA HM13 GSTP1 TXNRD2 SOD3 SOD1 CCS RPA1 RPA2 DCTN6 DCTN5 RAD50 DCTN1 RPA3 DCTN4 MAPK8 DYNLL2 HIF3A LIMD1 CUL2 VHL EGLN1 EGLN3 EGLN2 WTIP GSK3B EZH2 EED XPO1 NUP214 PRKCD MAPK7 ASF1A SUZ12 CAMK2B HSPA4L CAMK2D HSPH1 JUN MAPKAPK2 ST13 CAMK2A SOD2 EIF2AK4 LMNB1 PRDX2 CRYAB PRDX1 HSPA14 HSPA13 CAMK2G UBN1 NCOR2 CDKN2D CDKN2C TNRC6C MOV10 EPO HIKESHI CREB1 NCOR1 MAP3K5 ERF TNIK TNRC6A MT-CO1 BAG5 TNRC6B BAG2 BAG3 COX7A2L MAPK14 SCO1 BAG1 ARNT AQP8 MAPK11 SCO2 HIF1AN CLEC1B MT-CO2 HSPA1A DNAJC2 MT-CO3 CDKN1A IMPACT CDKN1B DNAJC7 TXN DNAJB6 SURF1 CCAR2 CCNA2 CCNA1 CCNE2 CCNE1 TP53 CDKN2A COX7B CDK2 HSPA12A COX7C MDM2 HSPA12B ID1 ATM MDM4 MINK1 COX8A HIRA MAP4K4 ETS1 FOS ETS2 RPS19BP1 RBX1 SP1 HIGD1A COX5B EP400 COX5A GCN1 HSPA9 HSPA5 HSPA4 PSPHP1 HSPA7 HSPA6 HMGA1 COX6C HMGA2 LRPPRC HSPB8 TACO1 CABIN1 COX6A1 CA9 KDM6B SESN2 COX6B1 COX19 COX16 COX18 COX11 COX14 TXN2 CYCS COX20 COX4I1 ASNS CUL3 NDUFA4 RELA PTK6 TXNIP HMOX1 SIGNALING BY NOTCH1%REACTOME DATABASE ID RELEASE 76%1980143 Signaling by NOTCH1 HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B TLE4 TLE2 TLE1 MIB2 MIB1 HEYL ARRB1 ARRB2 NBEA EP300 NUMB PSEN2 CDK8 APH1A APH1B KAT2B DNER KAT2A ITCH HDAC5 DTX1 HDAC8 DTX2 HDAC9 SKP1 DLL1 HDAC7 DLK1 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 HIF1A CNTN1 JAG1 UBA52 CUL1 DTX4 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 SIGNALING BY FGFR4%REACTOME DATABASE ID RELEASE 76%5654743 Signaling by FGFR4 BRAF GAB1 PIK3CA PLCG1 FRS3 SOS1 MKNK1 SPRY2 UBA52 MAPK1 MAPK3 PPP2CA PPP2CB UBB KLB HRAS UBC FGF1 RPS27A FGF2 FGF4 FGF6 NRAS PTPN11 FGF9 FGF20 PPP2R1A FGF23 PIK3R1 FRS2 FGF16 FGF19 FGF18 CBL FGFR4 UNFOLDED PROTEIN RESPONSE (UPR)%REACTOME DATABASE ID RELEASE 76%381119 Unfolded Protein Response (UPR) KDELR3 NFYA SHC1 NFYB NFYC GSK3A PPP2R5B CUL7 CXCL8 FKBP14 SULT1A3 SEC31A TLN1 CXXC1 MYDGF EXTL2 EXTL1 TATDN2 HSPA5 DNAJB9 SSR1 EXTL3 TSPYL2 LMNA KLHDC3 ZBTB17 DDX11 SYVN1 WIPI1 PDIA5 YIF1A CTDSP2 DNAJB11 SRPRA SRPRB HDGF TPP1 PLA2G4B SERP1 HYOU1 CEBPB CEBPG IGFBP1 EIF2S2 EIF2S1 EIF2S3 DDIT3 ARFGAP1 GFPT1 CREB3L3 DCTN1 GOSR2 ACADVL ATF3 ATF4 ATP6V0D1 CCL2 PDIA6 ADD1 ASNS HSP90B1 WFS1 EDEM1 CALR KHSRP MBTPS1 DIS3 ATF6 DNAJC3 EIF2AK3 HERPUD1 DCP2 MBTPS2 ERN1 CREB3 PARN CREB3L4 CREB3L1 EXOSC7 CREB3L2 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 CREBRF DCSTAMP EXOSC2 EXOSC1 PREB RUNX3 REGULATES CDKN1A TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%8941855 RUNX3 regulates CDKN1A transcription TGFB1 TP53 SMAD4 ZFHX3 SMAD3 RUNX3 CDKN1A MRNA EDITING: C TO U CONVERSION%REACTOME DATABASE ID RELEASE 76%72200 mRNA Editing: C to U Conversion APOBEC1 APOBEC3C APOBEC2 APOBEC4 APOBEC3H A1CF APOBEC3A APOBEC3B FGFR1 MUTANT RECEPTOR ACTIVATION%REACTOME DATABASE ID RELEASE 76%1839124 FGFR1 mutant receptor activation CUX1 ZMYM2 PIK3CA LRRFIP1 STAT3 ERLIN2 STAT5A STAT5B STAT1 CPSF6 FGF1 FGF2 FGF4 FGF6 FGFR1 BAG4 FGF9 FGF20 MYO18A FGF23 PIK3R1 BCR FGFR1OP2 GAB2 TRIM24 CEP43 DEFECTIVE UGT1A1 CAUSES HYPERBILIRUBINEMIA%REACTOME%R-HSA-5579002.3 Defective UGT1A1 causes hyperbilirubinemia UGT1A1 SIGNALING BY MAP2K MUTANTS%REACTOME DATABASE ID RELEASE 76%9652169 Signaling by MAP2K mutants MAP2K1 MAP2K2 MAPK1 MAPK3 TRAFFICKING OF AMPA RECEPTORS%REACTOME DATABASE ID RELEASE 76%399719 Trafficking of AMPA receptors PRKCB PRKCG MDM2 MYO6 GRIA2 DLG1 TSPAN7 DLG4 GRIA3 EPB41L1 GRIA4 PRKCA CAMK2B CAMK2D CAMK2A NSF CACNG8 CACNG2 CACNG3 CAMK2G AKAP5 PICK1 CACNG4 AP2A1 GRIP1 GRIA1 GRIP2 MINUS-STRAND DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 76%164516 Minus-strand DNA synthesis gag rev gag-pol vif PPIA vpr vpu SIGNALING BY WNT IN CANCER%REACTOME%R-HSA-4791275.3 Signaling by WNT in cancer PPP2R1B PPP2R5E TCF7L2 FZD8 FZD5 CTNNB1 CTBP2 FZD6 KREMEN1 CTBP1 PPP2R5B KREMEN2 PPP2R5A GSK3B PPP2R5D PPP2R5C AXIN1 AMER1 FZD4 PPP2CA PPP2CB RNF43 APC PORCN WNT3A PPP2R1A TNKS2 TNKS CSNK1A1 LRP5 DKK1 DKK2 DKK4 LRP6 RUNX3 REGULATES BCL2L11 (BIM) TRANSCRIPTION%REACTOME%R-HSA-8952158.1 RUNX3 regulates BCL2L11 (BIM) transcription FOXO3 BCL2L11 SMAD4 SMAD3 RUNX3 MHC CLASS II ANTIGEN PRESENTATION%REACTOME DATABASE ID RELEASE 76%2132295 MHC class II antigen presentation AP1M2 AP1M1 HLA-DOA HLA-DOB LAG3 RILP CTSO CTSF CTSE DNM1 DNM2 DNM3 KIF5C KIF5B KIF5A AP1G1 KIFAP3 RAB7A ACTR1A CANX CLTC KIF20A DCTN6 DCTN5 DCTN1 KLC1 DCTN4 DYNLL2 KLC4 SEC23A KLC3 KLC2 KIF3B LGMN RACGAP1 KIF3C DYNLL1 SEC24B KIF18A SEC24A KIF4B KIF4A DYNC1I2 DCTN2 SEC24D DCTN3 SEC24C KIF11 KIF15 CAPZB DYNC1H1 AP1B1 KIF23 KIF22 KIF2A AP1S2 AP1S1 KIF2C AP1S3 KIF2B DYNC1LI1 DYNC1LI2 SEC31A SPTBN2 CENPE CTSS KIF26A CAPZA1 CAPZA2 KIF3A ACTR1B CTSL CTSH CTSK CTSD CTSB ARF1 CTSC CLTA SEC13 AP2A1 CTSA AP2A2 OSBPL1A AP2M1 DYNC1I1 IFI30 CD74 SAR1B CAPZA3 AP2S1 ACTR10 HLA-DQA2 HLA-DQA1 HLA-DRB5 HLA-DRB4 AP2B1 HLA-DRB3 SH3GL2 HLA-DRB1 HLA-DPA1 HLA-DQB2 HLA-DQB1 HLA-DPB1 HLA-DRA HLA-DMA HLA-DMB TOLL LIKE RECEPTOR 7 8 (TLR7 8) CASCADE%REACTOME DATABASE ID RELEASE 76%168181 Toll Like Receptor 7 8 (TLR7 8) Cascade TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PELI1 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 NKIRAS1 NKIRAS2 SKP1 TLR7 MAPK8 NFKBIB TLR8 FBXW11 IRAK4 SAA1 MYD88 TICAM2 LY96 TICAM1 CD14 TLR4 IRF7 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 ECSIT CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA PELI3 RELA PELI2 RPS27A IKBKG MAPK9 NFKB2 MAP3K1 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 TLR9 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 MISMATCH REPAIR (MMR) DIRECTED BY MSH2:MSH6 (MUTSALPHA)%REACTOME DATABASE ID RELEASE 76%5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) POLD2 MSH6 MSH2 LIG1 PCNA RPA1 RPA2 PMS2 MLH1 RPA3 POLD3 POLD4 EXO1 POLD1 HCMV LATE EVENTS%REACTOME DATABASE ID RELEASE 76%9610379 HCMV Late Events H2AC17 H2AC12 NUP42 NUP43 RAE1 RANBP2 SCP NUP35 CVC2 CVC1 CHMP2B NUP37 H2AC21 CHMP2A H2AW NEC1 NEC2 US32 CHMP3 VPS37C US23 VPS37D US22 VPS37A CHMP6 VPS37B CHMP7 H2AC1 UL147A VPS4A MVB12B UL103 MVB12A UL102 UL104 H2BC18 NUP214 HNRNPK CHMP1A UL18 UL14 UL32 UL31 HELI UL38 UL35 UL29 UL26 UL25 UL24 UL23 UL54 DBP UL52 UL44 UL43 VPS36 UL48 UL47 UL76 UL74 UL71 UL70 UL79 VPS25 VPS28 UL131A UL41A UL69 UL112/UL113 UL91 UL99 UL97 UL96 UL36 UL95 UL94 RIR1 UL92 H2AC19 SNF8 UL80 UL88 UL87 H2AC14 UL84 H2BC21 UL83 UL82 H2BU1 UL2 H3C8 H2AC8 UL7 H2AC6 UL9 H2AC7 UL22A SEC13 H2BC17 H2BC12 H2BC13 H2BC14 MCP H2BC15 NUP107 RL11 NUP188 H2BC11 RL9A RL8A H3C15 NUP210 NUP93 POM121 NUP205 UL15A UL130 H2BC9 UL132 AAAS H4C9 TRM3 H2BC8 NUP160 TRM2 H2BC5 POM121C TRM1 NUP85 UL144 H2BC3 TPR UL147 NUP88 UL146 H2BC1 UL148 NUP155 gB gH gL NUP153 H2AC20 gM gN UL121 IRS1 UL120 UL122 UBAP1 UL117 TRS1 CHMP4C CHMP4B CHMP4A CEBPD NUP62 TRX1 NDC1 TRX2 UL111A TSG101 NUP133 NUP50 NUP54 RHO GTPASES ACTIVATE RHOTEKIN AND RHOPHILINS%REACTOME%R-HSA-5666185.1 RHO GTPases Activate Rhotekin and Rhophilins RTKN TAX1BP3 RHPN1 RHPN2 RHOC RHOB RHOA LIN7B ROPN1 G0 AND EARLY G1%REACTOME%R-HSA-1538133.3 G0 and Early G1 DYRK1A CCNA1 CCNE2 HDAC1 CCNE1 CDK2 RBBP4 LIN54 RBL2 RBL1 MYBL2 LIN52 PCNA E2F4 TOP2A LIN37 MAX LIN9 E2F5 TFDP1 TFDP2 E2F1 CDC6 MYC CDC25A CDK1 CCNA2 ENDOGENOUS STEROLS%REACTOME%R-HSA-211976.4 Endogenous sterols AHR CYP51A1 RXRA CYP19A1 POMC CYP11A1 CYP46A1 CYP7A1 NCOA1 NCOA2 PTGIS CYP11B2 CYP21A2 AHRR CYP11B1 CYP4V2 NR1H4 CYP7B1 ARNT2 CYP8B1 FDXR CYP27A1 CYP1B1 CYP39A1 ARNT FDX1 FDX2 COMMON PATHWAY OF FIBRIN CLOT FORMATION%REACTOME%R-HSA-140875.4 Common Pathway of Fibrin Clot Formation SERPINA5 THBD PF4V1 CD177 FGB F2 PF4 FGA SERPIND1 F10 F8 FGG PRTN3 F5 PROCR PROC F13B SERPINE2 F2R SERPINC1 PROS1 F13A1 REGULATION OF PTEN LOCALIZATION%REACTOME DATABASE ID RELEASE 76%8948747 Regulation of PTEN localization UBB UBA52 PTEN UBC XIAP RPS27A USP7 NEDD4 PML DEFECTIVE GALT CAN CAUSE GALACTOSEMIA%REACTOME DATABASE ID RELEASE 76%5609978 Defective GALT can cause Galactosemia GALT REGULATION OF TP53 ACTIVITY THROUGH ASSOCIATION WITH CO-FACTORS%REACTOME DATABASE ID RELEASE 76%6804759 Regulation of TP53 Activity through Association with Co-factors TP53 TP53BP2 BANP TP73 POU4F1 POU4F2 PPP1R13B AKT2 TP63 PHF20 AKT1 ZNF385A PPP1R13L AKT3 CONVERSION FROM APC C:CDC20 TO APC C:CDH1 IN LATE ANAPHASE%REACTOME%R-HSA-176407.4 Conversion from APC C:Cdc20 to APC C:Cdh1 in late anaphase CDC20 FZR1 CDC14A ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 ACTIVATION OF BID AND TRANSLOCATION TO MITOCHONDRIA%REACTOME DATABASE ID RELEASE 76%75108 Activation of BID and translocation to mitochondria GZMB BID CASP8 NMT1 INTERCONVERSION OF NUCLEOTIDE DI- AND TRIPHOSPHATES%REACTOME DATABASE ID RELEASE 76%499943 Interconversion of nucleotide di- and triphosphates TYMS GUK1 NME2P1 NUDT13 CTPS2 NME3 CTPS1 RRM2B TXNRD1 NME4 NME1 DCTD CMPK1 DCTPP1 DTYMK AK1 AK2 AK4 GLRX AK5 AK6 AK7 AK8 AK9 NME2 RRM1 RRM2 TXN MAP2K AND MAPK ACTIVATION%REACTOME%R-HSA-5674135.2 MAP2K and MAPK activation FN1 BRAF FGB FGA VWF FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CSK HRAS MARK3 WDR83 NRAS LAMTOR2 ITGB3 RAP1B RAP1A LAMTOR3 RAF1 KSR1 ARAF IQGAP1 KSR2 IL17RD SRC REGULATION OF HSF1-MEDIATED HEAT SHOCK RESPONSE%REACTOME%R-HSA-3371453.1 Regulation of HSF1-mediated heat shock response SIRT1 NUP42 NUP43 HSPA12A RAE1 HSPA12B RANBP2 ATM RPS19BP1 NUP35 NUP37 HSPA9 HSPA5 ATR HSPA4 MAPK1 HSPA7 HSPA6 MAPK3 HSPA8 YWHAE BAG4 SEC13 RPA1 RPA2 NUP107 NUP188 RPA3 DNAJB1 HSF1 HSPA1L HSPA2 NUP210 HSPA1B NUP93 POM121 NUP205 GSK3B AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP214 NUP153 HSPA4L MAPKAPK2 HSPH1 ST13 HSPA14 HSPA13 HIKESHI NUP62 NDC1 BAG5 BAG2 NUP133 BAG3 BAG1 DNAJC2 HSPA1A DNAJC7 NUP50 DNAJB6 NUP54 CCAR2 PHASE 3 - RAPID REPOLARISATION%REACTOME DATABASE ID RELEASE 76%5576890 Phase 3 - rapid repolarisation KCNQ1 KCNE1 KCNE2 KCNE3 KCNE4 KCNH2 KCNE5 AKAP9 AMINE OXIDASE REACTIONS%REACTOME%R-HSA-140179.2 Amine Oxidase reactions MAOB MAOA PAOX ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING%REACTOME DATABASE ID RELEASE 76%879415 Advanced glycosylation endproduct receptor signaling SAA1 DDOST HMGB1 APP CAPZA1 CAPZA2 AGER MAPK1 PRKCSH S100A12 S100B MAPK3 LGALS3 BIOGENIC AMINES ARE OXIDATIVELY DEAMINATED TO ALDEHYDES BY MAOA AND MAOB%REACTOME DATABASE ID RELEASE 76%141333 Biogenic amines are oxidatively deaminated to aldehydes by MAOA and MAOB MAOB MAOA ADHERENS JUNCTIONS INTERACTIONS%REACTOME%R-HSA-418990.2 Adherens junctions interactions CDH2 CTNNA1 CDH5 CDH9 CTNNB1 CDH8 CDH7 CDH6 CDH3 JUP CDH24 CADM2 ANG CDH10 CDH11 CDH12 CDH1 CDH13 CDH17 CDH18 CTNND1 CADM3 CADM1 CDH4 NECTIN4 NECTIN3 PVR NECTIN2 NECTIN1 CDH15 SORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 76%9674404 Sorafenib-resistant PDGFR mutants PDGFRA GENERATION OF SECOND MESSENGER MOLECULES%REACTOME DATABASE ID RELEASE 76%202433 Generation of second messenger molecules PLCG1 TRAC ITK CD3E GRAP2 TRBC1 LCK TRBV12-3 TRAV29DV5 TRBV7-9 PAK3 TRAV19 TRAV8-4 VASP HLA-DQA2 HLA-DQA1 WAS HLA-DRB5 CD4 HLA-DRB4 HLA-DRB3 HLA-DRB1 PAK2 CD3G LCP2 CD3D ENAH HLA-DPA1 HLA-DQB2 CD101 HLA-DQB1 HLA-DPB1 ZAP70 FYB1 EVL LAT HLA-DRA PAK1 PLCG2 NCK1 SEMAPHORIN INTERACTIONS%REACTOME DATABASE ID RELEASE 76%373755 Semaphorin interactions SEMA4D ITGB1 TLN1 FYN RHOC MYL12B PAK3 RHOB RRAS PLXNB1 PIP5K1C ARHGAP35 NRP1 HSP90AA1 ERBB2 MYH9 CD72 TYROBP DPYSL4 DPYSL5 PAK1 DPYSL2 DPYSL3 CDK5R1 HSP90AB1 MYL6 MYH14 MYH11 ARHGEF11 MYL9 MYH10 ARHGEF12 FES ROCK1 FARP2 SEMA5A RND1 ROCK2 GSK3B PLXND1 CDK5 PLXNC1 SEMA6A SEMA6D CRMP1 SEMA7A CFL1 PLXNA2 PLXNA1 LIMK2 LIMK1 PLXNA4 PLXNA3 PTPRC PAK2 PLXNB3 TREM2 RAC1 ITGA1 MET SEMA3A RHOA SEMA3E SEMA4A DEFECTIVE ABCC6 CAUSES PXE%REACTOME DATABASE ID RELEASE 76%5690338 Defective ABCC6 causes PXE ABCC6 SYNTHESIS OF IP3 AND IP4 IN THE CYTOSOL%REACTOME%R-HSA-1855204.3 Synthesis of IP3 and IP4 in the cytosol PLCD3 PLCB3 PLCD4 PLCB1 PLCD1 PLCB2 PTEN PLCG1 PLCB4 SYNJ1 PLD4 INPP5D INPPL1 OCRL ITPK1 INPP5B PLCZ1 PLCE1 CALM1 ITPKB ITPKC INPP5J ITPKA PLCG2 PLCH1 PLCH2 LECTIN PATHWAY OF COMPLEMENT ACTIVATION%REACTOME DATABASE ID RELEASE 76%166662 Lectin pathway of complement activation FCN1 FCN2 FCN3 MBL2 MASP1 COLEC11 COLEC10 TRAFFICKING OF MYRISTOYLATED PROTEINS TO THE CILIUM%REACTOME DATABASE ID RELEASE 76%5624138 Trafficking of myristoylated proteins to the cilium NPHP3 CYS1 RP2 UNC119B ARL3 LOSS OF MECP2 BINDING ABILITY TO THE NCOR SMRT COMPLEX%REACTOME DATABASE ID RELEASE 76%9022537 Loss of MECP2 binding ability to the NCoR SMRT complex NCOR1 HDAC3 GPS2 TBL1XR1 NCOR2 TBL1X THE CITRIC ACID (TCA) CYCLE AND RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-1428517.1 The citric acid (TCA) cycle and respiratory electron transport NDUFB4 SLC25A27 NDUFB3 UCP3 ETFDH UCP2 UCP1 NDUFB2 PDHB SLC25A14 NDUFB1 UQCR11 UQCR10 NDUFA9 NDUFA8 MDH2 NDUFA7 TIMMDC1 NDUFA6 SLC16A1 FAHD1 NUBPL NDUFA3 NDUFA2 NDUFA1 SUCLA2 GSTZ1 ATP5MC1 NDUFS3 CYC1 NDUFA5 CS ACO2 PPARD PM20D1 NDUFB8 ATP5F1A ATP5F1B PDHX IDH3G SLC16A8 SLC16A3 BSG NDUFC2 MT-CO1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 SURF1 OGDH COX7B COX7C DLAT COX8A RXRA COX5B COX5A DLD COX6C LRPPRC DLST TACO1 COX6A1 COX6B1 COX19 COX16 COX18 ETFB COX11 ADHFE1 COX14 D2HGDH NDUFAB1 L2HGDH CYCS COX20 MT-ND6 VDAC1 COX4I1 MT-ATP6 MT-ND4 NDUFA13 MT-ND5 NDUFA11 NDUFA12 NDUFA10 MT-ND2 PDHA2 MT-ND3 PDHA1 MT-ND1 SDHC ATP5MC2 SDHD ATP5MC3 SDHA SDHB UQCRC1 ATP5MG SUCLG2 ATP5MF SUCLG1 ATP5ME UQCRC2 DMAC2L TMEM126B ATP5PF NDUFA4 NDUFB10 ATP5PD UQCRB NDUFB11 ATP5PB UQCRH IDH2 NDUFV3 NDUFV2 NDUFV1 ATP5F1C TRAP1 ATP5F1D COA1 ATP5F1E NDUFAF6 MT-ATP8 NDUFAF7 UQCRQ ATP5PO NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 ECSIT NDUFAF1 MT-CYB ETFA TMEM186 NNT IDH3B UQCRFS1 ME3 ME2 GLO1 IDH3A LDHC ACAD9 LDHB NDUFC1 LDHA COQ10B COQ10A PDPR MPC1 NDUFS8 MPC2 NDUFS7 PDK4 NDUFS6 ME1 NDUFS5 PDK3 NDUFS4 PDK2 NDUFS2 PDK1 NDUFS1 NDUFB9 PDP1 FH PDP2 LDHAL6A NDUFB7 LDHAL6B NDUFB6 NDUFB5 DEFECTIVE ACY1 CAUSES ENCEPHALOPATHY%REACTOME DATABASE ID RELEASE 76%5579007 Defective ACY1 causes encephalopathy ACY1 REGULATION OF PAK-2P34 ACTIVITY BY PS-GAP RHG10%REACTOME DATABASE ID RELEASE 76%211728 Regulation of PAK-2p34 activity by PS-GAP RHG10 PAK2 ARHGAP10 HEME SIGNALING%REACTOME DATABASE ID RELEASE 76%9707616 Heme signaling HDAC3 CREBBP APOA1 RORA SIRT1 LY96 CLOCK NPAS2 ARNTL RXRA TLR4 RAI1 NRIP1 MEF2D PPARGC1A NR1D1 PPARA MAFK MEF2C PSPHP1 XPO1 NCOA1 HBB MED1 NFE2L2 NCOA2 SMARCD3 EP300 APOB CHD9 NCOA6 HELZ2 TBL1XR1 BACH1 TGS1 CARM1 TBL1X CREB1 NCOR1 SLC46A1 HBA2 CLEC1B ATF2 CRTC2 CRTC3 CRTC1 HMOX1 SIGNALING BY LEPTIN%REACTOME%R-HSA-2586552.2 Signaling by Leptin STAT5A STAT5B IRS1 LEP JAK2 IRS2 STAT3 PTPN11 SOCS3 REGULATION OF CHOLESTEROL BIOSYNTHESIS BY SREBP (SREBF)%REACTOME DATABASE ID RELEASE 76%1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) TM7SF2 CREBBP PMVK SC5D FDFT1 FDPS NFYA HMGCS1 GGPS1 NFYB NFYC CYP51A1 ELOVL6 RXRA LSS RAN SREBF2 SQLE SCD SP1 MTF1 PPARA DHCR7 MVD KPNB1 FASN SEC23A SEC24B SEC24A SAR1B SEC24D SEC24C MBTPS1 ACACA NCOA1 MED1 NCOA2 SMARCD3 MBTPS2 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X INSIG2 INSIG1 SCAP GPAM IDI1 MVK ACACB SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE%REACTOME%R-HSA-1660517.6 Synthesis of PIPs at the late endosome membrane VAC14 MTMR2 PIK3C2A PIK3R4 MTM1 MTMR9 FIG4 MTMR7 PIKFYVE MTMR4 PIK3C3 RNA POLYMERASE I PROMOTER ESCAPE%REACTOME DATABASE ID RELEASE 76%73772 RNA Polymerase I Promoter Escape CCNH POLR2E POLR2F POLR2H H2AX H2AB1 POLR2K H2AC19 POLR2L GTF2H1 GTF2H2 H2AC14 H2BC21 GTF2H3 GTF2H4 H2BU1 H3-3B GTF2H5 H3C8 CDK7 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H TAF1D H3C15 TAF1B TAF1C TAF1A H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 H2AC20 RRN3 UBTF FRS-MEDIATED FGFR4 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654712 FRS-mediated FGFR4 signaling KLB HRAS FGF1 FGF2 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF9 FGF20 FGF23 FRS2 FGF16 FGF19 FGF18 FGFR4 SIGNALING BY OVEREXPRESSED WILD-TYPE EGFR IN CANCER%REACTOME%R-HSA-5638302.1 Signaling by Overexpressed Wild-Type EGFR in Cancer HBEGF AREG TGFA EGFR EREG BTC EGF EPGN KETONE BODY CATABOLISM%REACTOME DATABASE ID RELEASE 76%77108 Ketone body catabolism ACAT1 BDH1 OXCT1 OXCT2 DISEASES OF CELLULAR SENESCENCE%REACTOME DATABASE ID RELEASE 76%9630747 Diseases of Cellular Senescence CDK6 CDKN2A CDK4 SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1%REACTOME DATABASE ID RELEASE 76%1839122 Signaling by activated point mutants of FGFR1 FGF23 FGF1 FGF2 FGF4 FGF6 FGFR1 FGF9 FGF20 PHASE 1 - INACTIVATION OF FAST NA+ CHANNELS%REACTOME DATABASE ID RELEASE 76%5576894 Phase 1 - inactivation of fast Na+ channels KCND1 KCNIP1 KCND2 KCNIP2 KCND3 KCNIP3 KCNIP4 FBXW7 MUTANTS AND NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 76%2644605 FBXW7 Mutants and NOTCH1 in Cancer RBX1 SKP1 NOTCH1 CUL1 RUNX3 REGULATES RUNX1-MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8951911.1 RUNX3 regulates RUNX1-mediated transcription CBFB RUNX3 CHROMATIN ORGANIZATION%REACTOME%R-HSA-4839726.2 Chromatin organization CREBBP PBRM1 ARID2 KDM1A PADI2 DPY30 KMT2A KDM7A HDAC8 PHF21A SETD1B SETD1A RCOR1 ASH2L RUVBL1 CCND1 CDK4 HMG20B ACTL6A JAK2 ATF2 RPS2 MCRS1 YEATS4 CLOCK TAF9 TAF12 TAF10 H2AX EHMT2 H2AB1 H2AC19 CHD4 CHD3 ACTB H2AC14 H2BC21 EP300 H2BU1 H3C8 RUVBL2 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 H2BC11 HDAC2 HDAC1 H3C15 MTA1 RBBP4 WDR5 RBBP7 MTA2 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 SMARCD1 SMARCD2 H2BC3 RBBP5 H2BC1 GATAD2B GATAD2A H2AC20 SMARCE1 NCOA1 NCOA2 SMARCD3 TBL1XR1 CARM1 TBL1X EHMT1 KAT5 PRMT6 KDM6A KMT5A KAT6A KDM3A KAT8 HDAC3 KAT7 TRRAP SUPT20H ATXN7L3 MEAF6 H2AC17 PADI3 H2AC12 PADI4 PADI1 PADI6 SMYD2 PRDM16 KAT14 HCFC1 SETDB1 SETDB2 KDM5B TADA2A ZZZ3 SUV39H2 BRPF1 SETD2 BRPF3 SETD3 TADA2B SETD6 H2AC21 SETD7 SGF29 ARID1A H2AW ING4 ARID1B ING3 PRMT7 PRMT3 PAX3 ASH1L SUPT3H ING5 TAF6L DOT1L NSD3 WDR77 NSD1 BRD8 ELP1 ELP2 PRMT5 ELP3 ELP4 BRD1 ELP5 ELP6 PRDM9 JADE1 JADE3 JADE2 KDM5A PHF2 KMT5B KMT5C KDM5C SUPT7L KDM5D MORF4L1 KDM3B PHF8 KAT6B MORF4L2 UTY KDM2A HAT1 KDM2B ENY2 TAF5L KDM4D ARID5B MBIP JMJD6 DMAP1 KDM1B SMYD3 RIOX2 DR1 COPRS MRGBP NFKB1 YEATS2 TADA1 BRWD1 H2AC1 VPS72 MSL2 MSL3 MSL1 ATF7IP ATXN7 KANSL1 KANSL2 KANSL3 TADA3 OGT ACTL6B ARID4B SAP130 SAP30 SUDS3 EZH2 SUV39H1 H2BC18 EED AEBP2 MECOM SAP30L SAP18 SUZ12 GPS2 USP22 NCOR2 NCOR1 PHF20 PRMT1 EP400 KMT2E KMT2D KMT2C KMT2B KDM6B NSD2 KDM4A KDM4B ARID4A KDM4C BRMS1 REST SMARCB1 EPC1 SMARCC1 SMARCC2 RELA NFKB2 HDAC10 SMARCA2 SMARCA4 BIOSYNTHESIS OF DHA-DERIVED SULFIDO CONJUGATES%REACTOME%R-HSA-9026395.1 Biosynthesis of DHA-derived sulfido conjugates GSTM4 LTC4S DEFECTIVE MGAT2 CAUSES MGAT2-CDG (CDG-2A)%REACTOME DATABASE ID RELEASE 76%4793952 Defective MGAT2 causes MGAT2-CDG (CDG-2a) MGAT2 SIGNALING BY INTERLEUKINS%REACTOME DATABASE ID RELEASE 76%449147 Signaling by Interleukins GSDMD CSF2 IRF4 FN1 GRB2 IL10 SYK IL18 FYN HCK MAPK1 IL1A IL1B MAPK3 PIM1 NOS2 LBP HSP90AA1 HGF MSN PPP2R1A TOLLIP BTRC PRKACA IGHG4 IGHG1 GATA3 SKP1 FBXW11 RPLP0 RAG2 RAG1 UBA52 MAP2K1 CUL1 IL6 UBB SNAP25 ITGAM UBC ITGB2 RPS27A ITGAX PIK3CD JAK2 RORA MIF IGHE LCK CAPZA1 MUC1 ALOX5 PTGS2 H3C8 TALDO1 PSMD8 CSF1 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 PPIA PSMA3 PSMA4 CNN2 PSMA1 PSMA2 PSME3 PSME4 HSP90B1 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 CHUK PAK2 TNIP2 PSMB8 P4HB PSMB9 SEM1 IKBKG PSMC5 PTPN12 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 RAP1B CSF3 TNFRSF1B TNFRSF1A ALOX15 APP VAV1 INPPL1 IL5RA CSF2RB IL2RG CSF2RA IL5 IL2RB IL3RA CANX NFKB1 FPR1 NKIRAS1 NKIRAS2 BRWD1 TCP1 NFKBIB IL23A IL23R STAT4 PTK2B IL12B TYK2 IL12RB1 CCR1 STAT3 MAOA CFL1 LYN YES1 PTPN13 VEGFA CCR5 CCR2 RORC ANXA1 RHOU SHC1 PIK3CA SOS1 SDC1 OPRD1 CCL11 PTAFR CCL19 ARF1 CCL22 CCL20 IRAK4 SAA1 MYD88 VAMP7 FASLG CRK HIF1A SOCS3 VAMP2 IL2RA FOXO1 PTPN4 BLNK STX4 STAT5A STAT5B CCL3L3 CISH NOD1 NOD2 AGER IRAK1 PTPN7 IRAK2 S100A12 RIPK2 COL1A2 SOCS2 S100B TRAF6 UBE2N SMARCA4 TAB3 TAB2 TAB1 SOCS5 UBE2V1 CXCL10 ANXA2 FCER2 ITGB1 CXCL8 MEF2A MEF2C CXCL1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CXCL2 CRKL IL2 STAT1 IL3 STX1A OPRM1 CD86 CD80 CSF3R JUNB RAPGEF1 CA1 PIK3R2 IL37 PTPN20 PTPN23 CCL5 PTPN14 IL18BP CCL4 PTPN9 CCL3 PTPN5 PTPN2 S1PR1 CCL2 IL18R1 STXBP2 IL32 POMC HNRNPF CCND1 MYC IL21 IL21R LGALS9 HAVCR2 IL15RA IL15 ATF2 HNRNPA2B1 FOXO3 TSLP IL7 CRLF2 SMAD3 IL1RL2 IL1RAPL1 IL1F10 IL9 IL9R TEC TNF CASP3 CTSG TIMP1 CSF1R MMP1 SQSTM1 MMP2 MMP3 MMP9 TBK1 IL1RN IL1R2 LAMA5 NANOG MAP3K3 SOCS1 IFNG SNRPA1 JAK1 F13A1 PITPNA BCL2 BCL2L1 SOS2 STAT6 INPP5D ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IRS1 MAPKAPK3 MAP2K7 IRS2 IRAK3 PELI3 PIK3CB SOX2 PELI2 FGF2 MAPK9 MAPK10 CEBPD TWIST1 PRTN3 GAB2 LIFR PPP2R1B POU2F1 MAP2K6 PPP2R5D CNTFR CNTF IL31RA ZEB1 CTF1 STX3 IL10RA CLCF1 IL13RA2 IL13RA1 TXLNA FSCN1 NDN MCL1 PTPRZ1 PPP2CA CD4 IL36A PPP2CB IL36B LIF GSTO1 IL36G LCN2 IL11 IL13 HSPA8 IL16 OSMR IL31 IL34 OSM BATF PTPN11 IL18RAP IL4R SOD1 IL11RA IL36RN IL4 PIK3R1 CDC42 RALA PTPN6 MAPK8 CBL PTPN18 GSTA2 AIP MTAP AKT1 DUSP4 DUSP3 VRK3 DUSP6 DUSP7 MAPK7 YWHAZ IL27 JUN MAPKAPK2 IL27RA IL12A SOD2 SERPINB2 LMNB1 LCP1 IL6ST EBI3 BOLA2B HNRNPDL IL12RB2 PDCD4 CRLF1 CREB1 MAPK14 MAPK11 CDKN1A TP53 FOS RBX1 HSPA9 HMGB1 CD36 PELI1 IL25 IL17RE IL17RC IL17RB IL17RA IL17F IL17C IL17A JAK3 IL6R IL1R1 BCL6 STAT2 CASP1 IL1RL1 IL33 BIRC5 ICAM1 IL22 VIM IL20 IL26 IL24 IL20RA IL20RB IL22RA2 IFNL2 IFNL1 IFNL3 IL10RB IL19 NFKBIA IFNLR1 RELA IL22RA1 NFKB2 TGFB1 PIK3R3 VCAM1 HMOX1 MAP3K7 DEFECTIVE SLC26A4 CAUSES PENDRED SYNDROME (PDS)%REACTOME%R-HSA-5619046.1 Defective SLC26A4 causes Pendred syndrome (PDS) SLC26A4 TNF SIGNALING%REACTOME%R-HSA-75893.6 TNF signaling RACK1 TAB1 TNFRSF1A TRAF1 CASP8 TRADD RIPK1 TRAF2 FADD BIRC2 UBA52 BIRC3 RNF31 XIAP SPPL2B SPPL2A TNF UL36 USP21 USP4 USP2 OTULIN UBB CLIP3 IKBKB UBC CHUK RBCK1 RPS27A NSMAF IKBKG TNFAIP3 BAG4 SHARPIN CRMA CYLD ADAM17 TAX1BP1 SPI-2 OTUD7B SMPD3 SMPD2 TAB3 MAP3K7 TAB2 CYTOKINE SIGNALING IN IMMUNE SYSTEM%REACTOME%R-HSA-1280215.5 Cytokine Signaling in Immune system GSDMD OAS1 CSF2 IRF4 OAS2 FN1 OAS3 IRF8 IRF5 IRF6 GRB2 USP41 EIF4E2 IRF9 SAMHD1 TRIM46 TRIM48 GBP2 FCGR1B IL10 GBP1 GBP4 GBP3 TRIM45 SYK MX2 IL18 MX1 FYN TRIM35 TRIM38 HCK MAPK1 ABCE1 TRIM31 IL1A TRIM34 IL1B MAPK3 KPNA1 PIM1 NOS2 LBP HSP90AA1 HGF KPNB1 IFNA13 IFNA14 IFNA16 IFNA17 MSN PPP2R1A TOLLIP IFNA10 BTRC PRKACA IGHG4 IGHG1 GATA3 SKP1 FBXW11 RPLP0 IFNA21 RAG2 RAG1 UBA52 MAP2K1 IFNA5 IFNA4 CUL1 HLA-H IFNA7 HLA-B HLA-C IFNA6 IL6 HLA-F HLA-G HLA-E UBB IFNA2 SNAP25 ITGAM UBC ITGB2 IFNA8 RPS27A ITGAX PIK3CD JAK2 SLA SLA2 FCGR1A IRF1 RORA IRF2 MIF ELOB PIAS1 ELOC FLT3 SH2B3 IGHE SUMO1 B2M HLA-A IFNB1 LCK CAPZA1 PTPRJ MUC1 ALOX5 PTGS2 NS H3C8 NEDD4 UBE2E1 UBE2D1 TALDO1 NUP107 NUP188 PSMD8 CSF1 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 H3C15 PSMD3 NUP210 PSMD1 PSMA5 NUP93 PSMA6 PPIA PSMA3 POM121 PSMA4 CNN2 NUP205 PSMA1 PSMA2 PSME3 PSME4 HSP90B1 PSME1 PSME2 PSMD10 AAAS PSMB11 PSMD12 PSMD11 NUP160 POM121C PSMD14 NUP85 PSMD13 TPR NUP88 PSMA7 PSMB10 PSMA8 NUP155 NCAM1 PSMB6 PSMB7 PSMB4 NUP153 PSMB5 PSMB2 IKBKB PSMB3 PSMB1 PSMF1 CHUK PAK2 TNIP2 PSMB8 P4HB DDX58 PSMB9 TRIM25 SEM1 IKBKG PSMC5 PTPN12 PSMC6 PSMC3 PSMC4 CUL5 PSMC1 PSMC2 RAP1B TNFRSF6B EDA ADAR NUP62 TNFRSF13B NDC1 TNFRSF11B EDA2R TNFSF13B TNFSF11 NUP133 TNFRSF17 TNFRSF8 TNFRSF14 TNFRSF4 TNFSF18 EDARADD TNFSF14 NUP50 TNFSF15 NUP54 CD70 CSF3 TNFRSF18 TNFRSF9 TNFSF13 TNFRSF1B TNFRSF1A EDAR TNFSF6 TNFSF4 NUP42 LTA NUP43 CD27 RAE1 TNFSF9 RANBP2 TNFRSF25 TNFSF8 TRAF2 NUP35 NUP37 ALOX15 APP VAV1 INPPL1 IL5RA CSF2RB IL2RG CSF2RA IL5 IL2RB IL3RA FLNA CANX NFKB1 FPR1 NKIRAS1 NKIRAS2 BRWD1 TCP1 NFKBIB IL23A IL23R STAT4 PTK2B IL12B TYK2 IL12RB1 CCR1 STAT3 MAOA CFL1 LYN YES1 CSK PTPN13 VEGFA CCR5 CCR2 RORC ANXA1 AKT3 RHOU SHC1 PIK3CA PLCG1 SOS1 SDC1 OPRD1 CCL11 PTAFR CCL19 ARF1 CCL22 CCL20 IRAK4 SAA1 MYD88 VAMP7 FASLG CRK HIF1A SOCS3 VAMP2 IL2RA PTPN1 FOXO1 PTPN4 AKT2 BLNK EIF4E STX4 STAT5A STAT5B CCL3L3 CSH1 PRL PRLR GHR GH1 CISH NOD1 NOD2 AGER IRAK1 PTPN7 IRAK2 S100A12 RIPK2 COL1A2 SOCS2 S100B TRAF6 UBE2N SMARCA4 TAB3 TAB2 SOCS6 TAB1 SOCS5 UBE2V1 KPNA7 CXCL10 ANXA2 KPNA4 KPNA5 KPNA2 KPNA3 EIF2AK2 FCER2 ITGB1 CXCL8 RNF7 MEF2A MEF2C CXCL1 ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 CXCL2 CRKL IL2 STAT1 IL3 STX1A OPRM1 CD86 CD80 CSF3R JUNB RAPGEF1 GRB10 CA1 PIK3R2 IL37 PTPN20 PTPN23 CCL5 PTPN14 IL18BP CCL4 PTPN9 CCL3 PTPN5 ABL2 PTPN2 S1PR1 CCL2 IL18R1 STXBP2 RELB UBA3 MAP3K14 IL32 UBE2M POMC PML HNRNPF CCND1 MYC IL21 IL21R LGALS9 HAVCR2 IL15RA ADAM17 IL15 ATF2 HNRNPA2B1 FOXO3 BCL2L11 TSLP IL7 CRLF2 SMAD3 KRAS EIF4A3 IL1RL2 IL1RAPL1 IL1F10 IL9 IL9R TEC TNF CASP3 CTSG TIMP1 CSF1R MMP1 SQSTM1 UBA7 UBE2D2 MMP2 UBE2D3 MMP3 MMP9 UBE2L6 HERC5 TBK1 SEC13 ISG15 IL1RN CD44 IL1R2 IRF3 LAMA5 NANOG TRAF3 MAP3K3 SOCS1 PIN1 IFNG IFNGR1 SNRPA1 IFNGR2 JAK1 F13A1 PITPNA BCL2 BCL2L1 TRIM21 IRF7 SOS2 STAT6 BIRC2 BIRC3 INPP5D ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IRS1 MAPKAPK3 MAP2K7 IRS2 IRAK3 PELI3 PIK3CB SOX2 PELI2 FGF2 MAPK9 MAPK10 CEBPD TWIST1 PRTN3 FLT3LG GAB2 LIFR IP6K2 PPP2R1B POU2F1 MAP2K6 GRAP2 PPP2R5D CNTFR CNTF IL31RA ZEB1 CTF1 STX3 IL10RA CLCF1 IL13RA2 IL13RA1 TXLNA FSCN1 NDN MCL1 PTPRZ1 PPP2CA CD4 IL36A PPP2CB IL36B LIF GSTO1 IL36G LCN2 IL11 IL13 HSPA8 IL16 OSMR IL31 IL34 OSM BATF PTPN11 IL18RAP IL4R SOD1 IL11RA IL36RN IL4 PIK3R1 CDC42 RALA PTPN6 MAPK8 CBL PTPN18 GSTA2 AIP MTAP TNFRSF12A TNFSF12 TNFRSF11A TNFRSF13C CD40LG AKT1 DUSP4 SP100 LTBR DUSP3 LTB NUP214 VRK3 DUSP6 PRKCD DUSP7 USP18 MAPK7 YWHAZ CAMK2B IL27 CAMK2D JUN MAPKAPK2 IL27RA IL12A CAMK2A SOD2 SERPINB2 LMNB1 LCP1 IL6ST EBI3 CAMK2G BOLA2B HNRNPDL IL12RB2 PDCD4 CRLF1 CREB1 MAPK14 MAPK11 EIF4G1 CDKN1A CDKN1B MT2A TP53 FOS RBX1 HSPA9 HMGB1 CD36 PELI1 IL25 IL17RE IL17RC IL17RB IL17RA IL17F IL17C IL17A JAK3 IL6R IL1R1 BCL6 IFNAR1 STAT2 EIF4A2 IFITM3 EIF4A1 CASP1 IL1RL1 IFITM1 IL33 IFITM2 IFIT5 IFI35 IFIT1 IFI30 IFIT3 BIRC5 ICAM1 IFIT2 TRIM29 TRIM26 TRIM22 GBP6 GBP5 RSAD2 IFI27 TRIM17 PDE12 TRIM14 IL22 VIM TRIM10 IL20 HLA-DQA2 IL26 HLA-DQA1 IL24 IL20RA EGR1 IL20RB HLA-DRB5 IL22RA2 HLA-DRB4 BST2 IFNL2 HLA-DRB3 IFNL1 HLA-DRB1 HRAS IFNL3 TRIM8 IL10RB TRIM6 IL19 NFKBIA TRIM5 IFNLR1 RELA IL22RA1 TRIM2 TRIM3 NFKB2 ARIH1 HLA-DPA1 HLA-DQB2 NRAS HLA-DQB1 RNASEL IFI6 gag FLNB HLA-DPB1 MID1 TGFB1 PIK3R3 VCAM1 ISG20 HLA-DRA XAF1 EIF4G3 EIF4G2 CIITA EIF4E3 OASL TRIM68 TRIM62 HMOX1 MAP3K7 PPM1B HEDGEHOG LIGAND BIOGENESIS%REACTOME%R-HSA-5358346.1 Hedgehog ligand biogenesis GPC5 DERL2 ERLEC1 SHH OS9 HHAT DHH IHH SYVN1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 PSME3 PSME4 SEL1L PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 DISP2 PSMB1 SCUBE2 PSMF1 UBC PSMB8 P4HB PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ADAM17 NOTUM NCAM SIGNALING FOR NEURITE OUT-GROWTH%REACTOME%R-HSA-375165.3 NCAM signaling for neurite out-growth COL6A2 COL4A3 SPTBN4 COL6A1 SPTBN5 COL4A5 SOS1 COL9A1 COL6A3 COL9A3 COL6A6 COL9A2 COL6A5 SPTBN2 AGRN FYN MAPK1 RPS6KA5 MAPK3 ARTN GFRA1 GFRA2 GFRA4 ST8SIA4 CNTN2 NRTN SPTB ST8SIA2 CACNA1D NCAN CACNA1C SPTAN1 CACNA1H SPTBN1 CACNA1G CACNA1I CACNA1S PRNP PSPN GDNF CACNB1 CACNB2 CACNB3 CACNB4 NCAM1 PTK2 HRAS PTPRA NRAS CREB1 SPTA1 COL4A2 COL4A1 COL4A4 THE AIM2 INFLAMMASOME%REACTOME%R-HSA-844615.1 The AIM2 inflammasome PYCARD AIM2 CASP1 SHC-MEDIATED CASCADE:FGFR3%REACTOME%R-HSA-5654704.2 SHC-mediated cascade:FGFR3 FGF23 HRAS FGF16 FGF1 FGF18 FGF2 SOS1 FGF4 NRAS FGF9 FGF20 RNA POLYMERASE III TRANSCRIPTION%REACTOME%R-HSA-74158.2 RNA Polymerase III Transcription POU2F1 CRCP ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP BRF2 GTF3A GTF3C1 GTF3C2 GTF3C3 NFIX GTF3C4 SSB GTF3C5 NFIA GTF3C6 NFIB BRF1 NFIC BDP1 POLR1C POLR1D CYTOSOLIC SULFONATION OF SMALL MOLECULES%REACTOME DATABASE ID RELEASE 76%156584 Cytosolic sulfonation of small molecules SULT1C2 SULT1C4 BPNT2 BPNT1 PODXL2 SULT1A1 SLC26A1 SULT1E1 SULT1A4 SULT1A3 SULT6B1 SULT1A2 SULT4A1 SLC35B3 SLC26A2 SLC35B2 ABHD14B SULT2A1 SULT1B1 PAPSS2 TPST2 PAPSS1 TPST1 PI-3K CASCADE:FGFR4%REACTOME DATABASE ID RELEASE 76%5654720 PI-3K cascade:FGFR4 KLB GAB1 FGF1 FGF2 PIK3CA FGF4 FGF6 PTPN11 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF19 FGF18 FGFR4 INTERFERON ALPHA BETA SIGNALING%REACTOME%R-HSA-909733.4 Interferon alpha beta signaling OAS1 IRF4 IRF1 IP6K2 OAS2 IRF2 OAS3 IRF8 IRF5 IRF6 IRF9 SAMHD1 HLA-A GBP2 IFNB1 MX2 MX1 ABCE1 KPNA1 KPNB1 IFNA13 IFNA14 IFNA16 PTPN11 IFNA17 ISG15 IFNA10 IRF3 SOCS1 PTPN6 JAK1 IFNAR1 STAT2 IFNA21 IFITM3 IFITM1 IFITM2 IFIT5 IFI35 IRF7 IFIT1 TYK2 SOCS3 IFIT3 IFIT2 PTPN1 RSAD2 IFNA5 IFI27 IFNA4 IFNA7 HLA-H HLA-B IFNA6 HLA-C HLA-F EGR1 HLA-G HLA-E USP18 IFNA2 BST2 PSMB8 IFNA8 RNASEL IFI6 ADAR ISG20 XAF1 OASL SUMOYLATION OF DNA DAMAGE RESPONSE AND REPAIR PROTEINS%REACTOME%R-HSA-3108214.2 SUMOylation of DNA damage response and repair proteins BLM CBX8 NUP42 CBX4 CDKN2A PIAS1 NUP43 CBX2 RAE1 RANBP2 BMI1 SUMO1 SUMO3 SUMO2 NUP35 NUP37 BRCA1 CETN2 TDG RNF2 WRN SEC13 RPA1 NUP107 NUP188 HDAC7 SMC5 SMC6 SMC3 HERC2 NUP210 NSMCE3 PHC2 NSMCE2 NUP93 PHC1 NSMCE1 RING1 POM121 EID3 NUP205 RAD21 XRCC4 STAG1 STAG2 AAAS PHC3 NUP160 POM121C SMC1A NUP85 TPR NUP88 RNF168 NSMCE4A NUP155 SP100 PML NUP214 NUP153 RAD52 PARP1 NUP62 MDC1 NDC1 NUP133 PCGF2 PIAS4 XPC NUP50 NUP54 UBE2I RECYCLING PATHWAY OF L1%REACTOME%R-HSA-437239.1 Recycling pathway of L1 RPS6KA4 L1CAM SHTN1 KIF4B KIF4A AP2S1 RPS6KA6 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 EZR DNM1 DNM2 AP2B1 DNM3 SH3GL2 NUMB RDX MSN CLTA CLTC AP2A1 AP2A2 DPYSL2 AP2M1 METABOLISM OF LIPIDS%REACTOME%R-HSA-556833.7 Metabolism of lipids CREBBP ELOVL1 FADS2 ELOVL5 ACSL1 ELOVL2 ELOVL3 FADS1 TXNRD1 AGK RAB5A KPNB1 CDK8 PPP1CB LPGAT1 PITPNB CYP27B1 CPNE7 CPNE6 CYP24A1 MFSD2A STARD7 CYP2R1 RUFY1 CYP2C9 CYP2C8 PLA1A CYP2D6 MTMR8 PRKACA PLA2G3 CYP1A2 CYP2E1 MTMR9 LPCAT1 MTMR6 CYP3A4 MTMR7 PGS1 PTDSS2 GGT1 PTDSS1 PTPMT1 INPP5J INPP5K TMEM86B STARD10 DPEP2 PEMT DPEP1 CDS2 DGAT2L7P ASAH1 DPEP3 OSBPL10 TNFAIP8L1 TNFAIP8L3 CYP17A1 TNFAIP8L2 PCYT1B PCYT1A PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLAAT4 PLEKHA1 PNPLA8 PLEKHA2 PLEKHA5 PLEKHA6 PLEKHA3 PLEKHA4 PLEKHA8 LPCAT3 LPCAT2 ACLY PNPLA3 GGT5 TPTE2 ABHD4 ABHD3 PLD4 PLD3 OSBPL8 OSBPL5 DGAT2L6 CRLS1 PI4KB TNFAIP8 PIK3C2G PIK3C2B TPTE AWAT2 MBOAT7 GM2A MBOAT1 MBOAT2 SIN3A CHPT1 PIK3CD VAPA PIAS4 CPNE1 UBE2I CPNE3 VDR NR1H2 ARSA RORA ARSB RXRA SUMO2 PPARG PPARA HMGCL ACSS3 GLIPR1 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ALOX5 PTGS2 PLB1 EP300 PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLBD1 GPCPD1 ORMDL3 PTGES2 CUBN APOA2 ALAS1 APOA1 APOA5 ANGPTL4 ALDH3B1 SAR1B ABCB4 NRF1 DEGS1 ABCA1 MBTPS1 NR1H3 ALB MBTPS2 AGPAT2 SLC22A5 GLA ABCD1 ME1 PNPLA2 HSD3B2 HSD3B1 HDAC3 RAN GPX2 CSNK2A1 GPX1 GPX4 ALOX15 CSNK2A2 ALOX12 ALOX12B ALOXE3 CSNK2B PLD1 INPPL1 VAPB PPARGC1B MTMR4 SLC27A1 LHB SPHK1 ACADVL SLCO1B1 FAAH MED16 ACAA2 MED15 ACSM3 MED17 ECI1 MED12 SLCO1B3 ACSM6 MED14 ACAD11 MED13 HADH MED10 ACAD10 PTGES3 ACOT9 MECR GBA ACOT7 ACOT11 ACSL6 ACOT12 ACSL5 ACOT13 ACSL3 ACOT1 CGA SLCO1A2 MED27 SLC27A3 MED26 PTGES HACD1 MED23 HACD3 MED25 HILPDA HACD2 MED24 CIDEA HACD4 MED20 FITM1 THEM5 FITM2 HSD17B13 HTD2 CIDEC MORC2 DECR1 ACBD7 ACBD6 ACBD4 TECRL ACSF3 MCAT ALOX15B ACSF2 PRXL2B PPT1 PPT2 ACOT7L SLC25A1 GK3P TECR MOGAT3 PCTP PTPN13 MOGAT2 DBI MOGAT1 ACOXL MCEE ABHD5 FABP12 ACADM ACADS GK2 PPP1CC CBR1 LIPE ELOVL4 AGMO FAAH2 ELOVL7 GPAT2 PTGR1 DGAT2 PTGR2 GK ACSBG1 DGAT1 ACSBG2 FABP9 PPP1CA PON3 FABP1 PON2 FABP2 PON1 FABP3 HSD17B3 FABP4 HSD17B12 HEXB GPAM LTC4S FABP5 HSD17B8 HEXA AWAT1 GPD2 FABP7 CBR4 OLAH PNPLA4 PNPLA5 ALOX5AP PLIN1 LPIN1 LPIN2 LPIN3 MGLL PIK3CA PLA2G6 PIP5K1C MVD MED30 MED31 ACBD5 NEU2 NEU3 ARF3 NEU1 HSD11B1 ARF1 HSD11B2 SERPINA6 ACHE BCHE CTSA FASN SRD5A3 AGT GLB1 MMAA MMUT DHRS7B SLC44A5 SLC44A3 SLC44A4 SLC44A2 RGL1 PSAP BMX PNPLA7 GDE1 GDPD1 GDPD3 PNPLA6 ENPP6 GDPD5 PECR SCP2 NUDT19 RAB4A PHYH RXRB GNPAT ACOT2 SYNJ2 PLD6 SYNJ1 HACL1 HAO2 EPHX2 PIK3C2A CPT2 MID1IP1 THRSP LBR SLC25A20 CPT1B PPARD CROT TAZ CYP11B1 OCRL TRIB3 MED8 SLC25A17 ABCC1 MED4 PIK3R2 MED6 AGPS SEC23A MED7 ACOX3 LRP2 SEC24B SEC24A CAV1 RAB14 NUDT7 POMC CRAT SEC24D SEC24C ESYT1 HADHB HADHA ACADL PEX11A FHL2 ANKRD1 TNFRSF21 G0S2 GRHL1 MSMO1 NSDHL PLPP6 INSIG2 INSIG1 IDI2 ACAT2 INPP5E EBP SCAP DHCR24 ARV1 HSD17B7 GC CLOCK NPAS2 ARNTL PPARGC1A NR1D1 TIAM2 AGPAT1 TSPOAP1 ESRRA MED19 MED18 MED11 SMPD3 MED29 SMPD2 MED28 MED22 MED21 MED13L NCOA3 VAC14 MTMR10 MTMR12 MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F MED9 PI4K2A GLB1L PCCA INPP5D PCCB ACACA NCOA1 SBF1 MED1 SBF2 PIK3R4 NCOA2 CDK19 CPT1A PIK3CB SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 MTMR3 TGS1 CARM1 TBL1X THEM4 PTGDS MTMR14 FDXR CYP1B1 PIP4K2A SCD5 PIP4K2B SULT2A1 THRAP3 PIP4K2C FAM120B PIK3C3 CYP2U1 FDX1 FDX2 CHKB PCYT2 CHKA SELENOI PISD ETNPPL PHOSPHO1 ETNK2 ETNK1 CEPT1 PLA2G4A GSTM4 PLA2G2A CYP4F2 CYP4F3 CYP4F8 ALPI CYP1A1 PIP4P1 PRKAB2 CYP21A2 AHRR PRKAA2 PLIN3 PRKAG2 PLIN2 PTGS1 FAR1 PIK3R1 FAR2 ARNT2 AGPAT3 LGMN CHAT AHR HPGDS HPGD LTA4H CYP4F22 CYP2C19 CYP19A1 CYP11A1 PIP5K1A PIP5K1B CYP2J2 CYP4F11 MAPKAPK2 CYP11B2 GPS2 TBXAS1 CYP4A22 NCOR2 NCOR1 CYP4A11 ARNT IDI1 MVK ACACB TM7SF2 PMVK SC5D FDFT1 SLC44A1 FDPS NFYA HMGCS1 GGPS1 NFYB NFYC UGT1A9 CYP51A1 ELOVL6 PRKACG LSS PRKACB SREBF2 SQLE SCD SP1 CYP4B1 MTF1 DHCR7 ECHS1 HSD17B14 AKR1B1 HSD17B11 CD36 AKR1D1 HSD17B1 HSD17B4 HSD17B2 TSPO CYP46A1 STARD3 ABCB11 AGPAT5 STARD4 CYP7A1 PLA2G1B PLA2G5 OSBP SRD5A2 LCLAT1 OSBPL9 STARD3NL STARD6 ABCC3 AGPAT4 GPAT4 SRD5A1 HSD3B7 LIPI ACOT8 STAR EHHADH LIPH OSBPL7 DECR2 AKR1B15 ACOT6 OSBPL6 ACP6 GPAT3 ACAA1 PTGIS STARD5 ACOT4 PLA2G2F CDS1 SLC10A1 PLA2G2D PLA2G12A PITPNM1 AKR1C1 OSBPL3 PIK3R6 PITPNM3 PLA2G2E PIK3CG SLC10A2 PITPNM2 MIGA2 OSBPL2 PIK3R5 MIGA1 CDIPT DDHD2 AKR1C3 NR1H4 DDHD1 NDUFAB1 LPCAT4 AKR1C2 AKR1C4 GPD1 BAAT PLA2G10 PI4K2B CYP7B1 GPD1L MTMR2 PLA2R1 CYP8B1 GLTP SACM1L CYP27A1 CERK CYP39A1 PI4KA CH25H GBA3 GBA2 AMACR SPTLC1 ACOX2 SMPD4 FABP6 OSBPL1A STS SLC27A2 SPTLC2 SLC27A5 SPTLC3 SMPD1 ENPP7 CERS3 CERS4 CERS5 CERS6 SPHK2 ACAT1 PTEN SPNS2 SUMF2 SUMF1 PRKD3 CPTP PRKD2 PRKD1 PLPP3 PLPP2 CERS1 PLPP1 CSNK1G2 CERS2 ASAH2 SAMD8 SGMS1 PPM1L SGMS2 UGCG UGT8 ALDH3B2 SGPL1 ARSL ORMDL2 ARSJ ARSK ARSH ARSI SPTSSB B4GALNT1 ARSF SPTSSA ARSG KDSR ARSD B3GALNT1 ORMDL1 SGPP2 SGPP1 GALC ACER2 ACER1 FA2H ACER3 ESYT3 ESYT2 DEGS2 CCNC PIK3R3 PLD2 MTMR1 DEFECTIVE ALG1 CAUSES ALG1-CDG (CDG-1K)%REACTOME DATABASE ID RELEASE 76%4549380 Defective ALG1 causes ALG1-CDG (CDG-1k) ALG1 RHOA GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%8980692 RHOA GTPase cycle FARP1 STARD8 DIAPH1 DAAM1 IQGAP3 TRIO TFRC STARD13 ARHGDIA JUP MCF2L SNAP23 VAV3 ARHGAP9 PLEKHG3 ARHGAP8 ARHGAP1 ARHGAP39 ARHGAP4 VAV1 ARHGAP5 ARHGAP6 ARHGAP35 ARHGEF5 PREX1 GMIP PLD1 ARHGAP42 CIT KALRN OPHN1 HMOX2 STBD1 ARHGDIB PKN3 ERBIN VAPB LBR TMPO ARAP2 ARAP3 MYO9B PIK3R1 VAV2 BCR IQGAP1 TIAM1 ABCD3 VAMP3 PKN2 PIK3R2 ATP6AP1 PKN1 LMAN1 ARHGAP21 ABR PGRMC2 FAM13A RACGAP1 STK10 MYO9A SLK VANGL1 DEPDC1B TEX2 ARHGEF7 YKT6 DDRGK1 CAV1 MCAM STOM MCF2 ARHGAP26 ARHGAP11A ARHGAP11B ARHGAP32 TAGAP DIAPH3 ARHGEF28 PLEKHG4 PLEKHG6 FLOT2 SRGAP1 PLEKHG5 PCDH7 KTN1 TMEM87A ANLN FAF2 CCDC115 DOCK2 EMC3 BCAP31 SCFD1 CAVIN1 DLC1 TJP2 RTKN RASGRF2 ARHGAP44 ARHGAP40 ARHGAP45 ARHGEF40 FLOT1 ARHGEF25 ARHGAP19 ARHGAP18 ARHGAP22 ARHGAP20 OBSCN RHPN1 RHPN2 ACBD5 PREX2 NGEF ARHGAP29 MACO1 ARHGAP28 ARHGAP24 ARHGAP23 ARHGAP31 ARHGAP30 ECT2 NET1 FMNL3 ARHGEF10L ACTC1 AKAP13 C1QBP ARHGEF11 ARHGEF10 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGAP10 ARHGEF3 ARHGEF4 ROCK1 ARHGEF1 ROCK2 ARHGEF2 AAAS STX5 ARAP1 ARHGEF18 DEF6 RHOA SOWAHC FGFR3C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190372.3 FGFR3c ligand binding and activation FGF23 FGF16 FGF1 FGF18 FGF2 FGF4 GALNT3 FGF9 FGF20 REGULATION OF GENE EXPRESSION IN ENDOCRINE-COMMITTED (NEUROG3+) PROGENITOR CELLS%REACTOME%R-HSA-210746.1 Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells NEUROG3 NEUROD1 NKX2-2 PAX4 INSM1 REGULATION OF LIPID METABOLISM BY PPARALPHA%REACTOME DATABASE ID RELEASE 76%400206 Regulation of lipid metabolism by PPARalpha CREBBP HDAC3 ACSL1 FADS1 RXRB TXNRD1 CYP1A1 CPT2 PPARGC1B AHRR CDK8 PLIN2 ARNT2 SLC27A1 TRIB3 MED8 MED16 MED4 MED15 MED6 MED17 MED7 MED12 MED14 MED13 MED10 AHR MED27 MED26 MED23 MED25 MED24 MED20 PEX11A FHL2 GPS2 ANKRD1 ACADM TNFRSF21 G0S2 GRHL1 SIN3A NCOR2 NCOR1 CYP4A11 FABP1 ARNT NR1H2 RORA FDFT1 NFYA HMGCS1 CLOCK NFYB NFYC NPAS2 UGT1A9 ARNTL RXRA SREBF2 SP1 PPARG PPARGC1A MTF1 NR1D1 PPARA GLIPR1 CD36 HMGCS2 CYP7A1 TIAM2 MED30 MED31 EP300 NR1H4 ESRRA MED19 MED18 MED11 AGT MED29 MED28 APOA2 MED22 ALAS1 APOA1 MED21 APOA5 ANGPTL4 MED13L ABCB4 NRF1 NCOA3 MED9 ABCA1 NR1H3 NCOA1 MED1 NCOA2 CPT1A CDK19 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 RGL1 CARM1 TBL1X CCNC SULT2A1 ME1 THRAP3 FAM120B GILTERITINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702590 gilteritinib-resistant FLT3 mutants FLT3 VITAMIN B1 (THIAMIN) METABOLISM%REACTOME DATABASE ID RELEASE 76%196819 Vitamin B1 (thiamin) metabolism TPK1 THTPA SLC19A3 SLC19A2 SLC25A19 SIGNALING BY ERYTHROPOIETIN%REACTOME%R-HSA-9006335.3 Signaling by Erythropoietin CRKL STAT5A STAT5B HRAS IRS2 SHC1 PIK3CB GAB1 PIK3CA PLCG1 PIK3CG SOS1 PIK3R5 NRAS EPO PIK3CD PIK3R1 JAK2 EPOR RAPGEF1 VAV1 LYN PLCG2 SYNTHESIS OF UDP-N-ACETYL-GLUCOSAMINE%REACTOME DATABASE ID RELEASE 76%446210 Synthesis of UDP-N-acetyl-glucosamine UAP1 PGM3 GFPT2 GNPNAT1 GFPT1 AMDHD2 NAGK RENBP ALPHA-DEFENSINS%REACTOME%R-HSA-1462054.1 Alpha-defensins CD4 DEFA6 DEFA4 DEFA5 DEFA3 ART1 env DEFA1B PRSS3 PRSS2 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR2%REACTOME%R-HSA-5654221.2 Phospholipase C-mediated cascade; FGFR2 FGF1 FGF2 FGF3 PLCG1 FGF4 FGF6 FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P16INK4A DEFECTS%REACTOME DATABASE ID RELEASE 76%9632693 Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects CDK6 CDKN2A CDK4 SIGNALING BY ROBO RECEPTORS%REACTOME DATABASE ID RELEASE 76%376176 Signaling by ROBO receptors CXCL12 COL4A5 PAK3 ARHGAP39 MYO9B PRKACA RPL4 RPL5 RPL30 RPL3 HOXA2 RPL32 RPL31 RPL34 RPLP1 ISL1 RPL10L RPLP0 RPL10A RPL8 ABL1 RPL6 RPL7 FLRT3 UPF3A RPS4X RPS15 ABL2 RPL7A RPS14 RPS17 UPF2 RPS16 SRGAP2 RPL18A RPS19 ZSWIM8 RPS18 PAK4 RPL36AL RPL36 RPL35 RPLP2 MSI1 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 NCBP1 RPS8 SRGAP3 NCBP2 RPS5 UBB SRGAP1 RPL23 RPL22 RPS6 UBC RPL13A RPSA LHX3 RPS3A RPS27A RPL9P9 LHX2 RPL37A RPL24 RPL27 LHX4 CLASP1 LHX9 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RAC1 RPL10 RPL12 RPL11 RPL36A RPS27L EVL RPS4Y1 GSPT2 GSPT1 RPS15A RPL14 RPS3 RPL13 RPS2 SRC RPL15 RPL18 RPL17 RPL19 NELL2 RPL39L RPL41 DAG1 RPL35A RPL23A RPL3L RPS26 ELOB RPS25 ELOC RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU EIF4A3 RPS21 PFN1 CASC3 RPL26L1 RPS24 MAGOH PFN2 RPS23 VASP ROBO2 NRP1 ROBO1 CAP1 RBM8A ENAH AKAP5 PAK5 CAP2 UPF3B MAGOHB RNPS1 DCC PSMD8 PSMD9 NTN1 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 LDB1 PSME3 PSME4 PSME1 SOS2 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 SLIT1 PSMA7 PSMB10 SLIT3 PSMA8 PSMB6 SLIT2 PSMB7 PSMB4 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDC42 PAK1 NCK2 PAK6 NCK1 CUL2 USP33 PRKCA PABPC1 EIF4G1 GPC1 SOS1 PRKACG PRKACB RBX1 PRKAR2A CXCR4 RHOA PPP3CB CITRIC ACID CYCLE (TCA CYCLE)%REACTOME%R-HSA-71403.2 Citric acid cycle (TCA cycle) OGDH CS MDH2 ACO2 NNT IDH3B FAHD1 SDHC ME3 IDH3G SDHD ME2 SDHA IDH3A SDHB SUCLA2 SUCLG2 SUCLG1 DLD IDH2 FH DLST NEGATIVE REGULATION OF MET ACTIVITY%REACTOME%R-HSA-6807004.1 Negative regulation of MET activity SH3KBP1 UBB HGF EPS15 SH3GL2 UBC SH3GL1 HGS LRIG1 RPS27A PTPN2 PTPN1 STAM2 UBA52 PTPRJ MET USP8 STAM SH3GL3 CBL SIGNALING BY NTRK2 (TRKB)%REACTOME DATABASE ID RELEASE 76%9006115 Signaling by NTRK2 (TRKB) HRAS GAB1 PIK3CA PLCG1 FRS3 SOS1 NRAS PTPN11 CDK5 RAC1 PIK3R1 NTF4 BDNF TIAM1 FRS2 GRIN2B DOCK3 SRC CDK5R1 NTRK2 NTF3 ABC-FAMILY PROTEINS MEDIATED TRANSPORT%REACTOME DATABASE ID RELEASE 76%382556 ABC-family proteins mediated transport DERL1 DERL2 RNF5 ERLEC1 OS9 PEX19 KCNJ11 ABCA10 ABCB1 ABCB7 ABCB5 ABCB8 ABCG4 ABCB9 ABCA2 ABCA5 ABCA6 ABCA4 ABCA9 ABCA7 ABCA8 EIF2S2 EIF2S1 ABCD2 EIF2S3 ABCD3 ABCC10 ABCC11 ABCC4 ABCC1 ABCC5 PEX3 ABCB10 UBA52 ABCF1 UBB UBC RPS27A CFTR ABCC3 ABCA12 PSMD8 PSMD9 PSMD6 APOA1 PSMD7 ABCG8 PSMD4 ABCG5 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 VCP PSMA3 PSMA4 ABCG1 PSMA1 ABCB6 PSMA2 PSME3 ABCB4 PSME4 SEL1L PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 ABCA3 PSMB6 ERLIN1 PSMB7 PSMB4 ERLIN2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 RNF185 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABCD1 ABCC2 ABCC6 ABCC9 DERL3 PKB-MEDIATED EVENTS%REACTOME%R-HSA-109703.4 PKB-mediated events PDE3B AKT2 SENSORY PROCESSING OF SOUND BY INNER HAIR CELLS OF THE COCHLEA%REACTOME DATABASE ID RELEASE 76%9662360 Sensory processing of sound by inner hair cells of the cochlea CLIC5 RIPOR2 CIB2 PJVK ESPN EPS8 TPRN PLS1 TMC1 KCNMA1 CAPZA1 MYO7A CAPZA2 TMC2 PCLO MYO3B BSN CASK MYO3A CACNA2D2 KCNQ4 SYP FSCN2 SYN1 EZR PCDH15 CABP2 USH1C CABP1 TWF2 LRRC52 TWF1 OTOF ESPNL EPB41L1 EPB41L3 KCNMB1 CDH23 XIRP2 EPS8L2 GRXCR1 GRXCR2 STX1A WHRN RDX MYH9 LHFPL5 MSN ATP2B1 TMIE USH1G MYO15A STRC CACNA1D SPTAN1 SPTBN1 VAMP2 MYO1C CACNB2 SNAP25 RAB3A CAPZB DNAJC5 SLC17A8 DEFECTIVE MISMATCH REPAIR ASSOCIATED WITH MSH2%REACTOME DATABASE ID RELEASE 76%5632928 Defective Mismatch Repair Associated With MSH2 MSH3 MSH6 MSH2 METALLOPROTEASE DUBS%REACTOME%R-HSA-5689901.2 Metalloprotease DUBs H2AC17 H2AC12 MYSM1 BRCC3 BARD1 H2AC21 UBA52 H2AW NLRP3 PSMD14 BABAM1 BABAM2 STAM BRCA1 UIMC1 ABRAXAS1 ABRAXAS2 H2AC20 H2AC19 UBB H2AC14 UBC STAMBPL1 EP300 RPS27A H2AC8 H2AC6 H2AC7 KAT2B H2AC1 STAMBP NEGATIVE REGULATION OF FGFR1 SIGNALING%REACTOME DATABASE ID RELEASE 76%5654726 Negative regulation of FGFR1 signaling BRAF MKNK1 SPRY2 UBA52 MAPK1 MAPK3 PPP2CA PPP2CB UBB UBC FGF1 RPS27A FGF2 FGF3 FGF4 FGF6 PTPN11 ANOS1 FGF9 FGF20 PPP2R1A FGF23 FGF22 FRS2 CBL FGF10 TRAF6 MEDIATED NF-KB ACTIVATION%REACTOME%R-HSA-933542.1 TRAF6 mediated NF-kB activation IFIH1 SAA1 IKBKB RNF135 MAVS CHUK DDX58 NFKBIA RELA TRIM25 NFKB2 IKBKG MAP3K1 TRAF2 HMGB1 APP AGER NFKB1 S100A12 NKIRAS1 S100B NKIRAS2 TRAF6 NFKBIB HSF1-DEPENDENT TRANSACTIVATION%REACTOME%R-HSA-3371571.1 HSF1-dependent transactivation CREBBP HSBP1 DNAJB1 HSPA1L HSF1 PTGES3 CAMK2B HSP90AA1 HSPA2 MTOR CAMK2D HSPA8 CAMK2A EP300 FKBP4 CRYAB HSPA1B AKT1S1 CAMK2G RPTOR HSPA1A MLST8 HSPB8 HSP90AB1 MPS I - HURLER SYNDROME%REACTOME DATABASE ID RELEASE 76%2206302 MPS I - Hurler syndrome IDUA RNA POLYMERASE II PROMOTER ESCAPE%REACTOME%R-HSA-73776.3 RNA Polymerase II Promoter Escape GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 NEGATIVE REGULATION OF FLT3%REACTOME%R-HSA-9706369.1 Negative regulation of FLT3 SOCS6 UBB CSK UBC ABL2 RPS27A FLT3 SH2B3 UBA52 FLT3LG SLA SLA2 PTPRJ SOCS2 CBL CARGO CONCENTRATION IN THE ER%REACTOME%R-HSA-5694530.1 Cargo concentration in the ER LMAN1 COL7A1 CD59 LMAN2L TGFA F8 SEC24B SEC24A SAR1B F5 CNIH1 SEC24D SEC24C FOLR1 LMAN2 CNIH2 STX5 CNIH3 MCFD2 CTSZ MIA2 MIA3 TMED2 CTSC SERPINA1 LMAN1L TMED10 GRIA1 AREG GOSR2 SEC22B PREB SEC23A TRANSCRIPTIONAL ACTIVATION OF MITOCHONDRIAL BIOGENESIS%REACTOME%R-HSA-2151201.2 Transcriptional activation of mitochondrial biogenesis HDAC3 CREBBP HCFC1 RXRA MEF2D PPARGC1A PPARA NR1D1 MEF2C PPARGC1B SIRT3 ESRRA CALM1 TFB1M CYCS ALAS1 MTERF1 GABPA TWNK ATP5F1B SIRT4 SIRT5 PPRC1 POLG2 PERM1 TFAM NRF1 TFB2M POLRMT IDH2 NCOA1 SSBP1 MED1 NCOA2 SOD2 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X CREB1 NCOR1 CAMK4 GLUD1 GLUD2 ATF2 CRTC2 CRTC3 CRTC1 ACSS2 BIOSYNTHESIS OF EPA-DERIVED SPMS%REACTOME%R-HSA-9018679.1 Biosynthesis of EPA-derived SPMs ALOX5 LTA4H PTGS2 ALOX15 HPGD GLYCOGEN BREAKDOWN (GLYCOGENOLYSIS)%REACTOME%R-HSA-70221.3 Glycogen breakdown (glycogenolysis) GAA GYG1 PGM2L1 AGL PHKA1 PHKA2 GYG2 PYGM PHKB PHKG1 PYGB PHKG2 PYGL CALM1 PGM2 METHYLATION OF MESEH FOR EXCRETION%REACTOME%R-HSA-2408552.2 Methylation of MeSeH for excretion INMT L13A-MEDIATED TRANSLATIONAL SILENCING OF CERULOPLASMIN EXPRESSION%REACTOME DATABASE ID RELEASE 76%156827 L13a-mediated translational silencing of Ceruloplasmin expression EIF2S2 EIF2S1 EIF2S3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF4H EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 EIF4A1 EIF4E EIF4B CREATION OF C4 AND C2 ACTIVATORS%REACTOME%R-HSA-166786.2 Creation of C4 and C2 activators V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 V5-6 IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 IGLV1-51 IGLV2-23 IGKV3-20 FCN1 FCN2 IGHV4-34 FCN3 IGHV1-2 IGHV4-39 IGKV2-29 MASP1 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 MBL2 IGKV2-30 IGHV2-70 IGHV2-5 C1QB IGHV3-48 CRP IGLV3-1 C1QA COLEC11 COLEC10 IGKV1-39 C1S IGKV1-33 C1R IGHV3-53 IGLC7 IGKV5-2 IGLC6 C1QC IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 ARMS-MEDIATED ACTIVATION%REACTOME%R-HSA-170984.4 ARMS-mediated activation NGF BRAF YWHAB CRK NTRK1 RAP1A KIDINS220 NORC NEGATIVELY REGULATES RRNA EXPRESSION%REACTOME DATABASE ID RELEASE 76%427413 NoRC negatively regulates rRNA expression CCNH POLR2E POLR2F POLR2H H2AX H2AB1 POLR2K H2AC19 POLR2L GTF2H1 TTF1 GTF2H2 H2AC14 H2BC21 GTF2H3 GTF2H4 H2BU1 H3-3B GTF2H5 H3C8 CDK7 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 TAF1D H3C15 TAF1B TAF1C ARID4B TAF1A H2BS1 SAP130 SAP30BP SAP30 DNMT1 BAZ2A H2AZ1 SUDS3 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 SIN3B DNMT3B H2BC3 SMARCA5 H2BC1 H2AC20 SAP30L SAP18 MBD2 SIN3A UBTF DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE%REACTOME%R-HSA-9670621.1 Defective Inhibition of DNA Recombination at Telomere DAXX ATRX REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN%REACTOME%R-HSA-170822.3 Regulation of Glucokinase by Glucokinase Regulatory Protein NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 GCK NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 GCKR NUP155 NUP214 NUP153 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 CA ACTIVATED K+ CHANNELS%REACTOME DATABASE ID RELEASE 76%1296052 Ca activated K+ channels KCNN2 KCNMB1 KCNMB2 KCNMA1 KCNMB3 KCNMB4 KCNN1 KCNN3 KCNN4 DEFECTIVE SLC33A1 CAUSES SPASTIC PARAPLEGIA 42 (SPG42)%REACTOME DATABASE ID RELEASE 76%5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) SLC33A1 SIGNALING BY CSF3 (G-CSF)%REACTOME%R-HSA-9674555.1 Signaling by CSF3 (G-CSF) SHC1 ELOB GRB2 ELOC KRAS SOCS3 TYK2 SYK RNF7 UBA52 STAT3 HCK LYN UBB STAT5A STAT5B STAT1 UBC UBE2D2 UBE2D3 RPS27A CUL5 PTPN11 CSF3R UBE2D1 JAK2 GAB2 SOCS1 JAK1 CSF3 ABC TRANSPORTER DISORDERS%REACTOME DATABASE ID RELEASE 76%5619084 ABC transporter disorders DERL1 DERL2 CFTR RNF5 ERLEC1 OS9 KCNJ11 ABCB11 ABCA12 PSMD8 PSMD9 PSMD6 APOA1 PSMD7 ABCG8 PSMD4 ABCG5 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 VCP PSMA4 PSMA1 PSMA2 ABCB6 PSME3 ABCB4 PSME4 SEL1L PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 ABCA1 PSMA8 PSMB6 ABCA3 PSMB7 ERLIN1 PSMB4 PSMB5 ERLIN2 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 RNF185 ABCD4 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 ABCD1 ABCC2 ABCC8 ABCC6 ABCC9 DERL3 METABOLISM OF INGESTED H2SEO4 AND H2SEO3 INTO H2SE%REACTOME%R-HSA-2408550.2 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se PAPSS2 PAPSS1 TXNRD1 APC C-MEDIATED DEGRADATION OF CELL CYCLE PROTEINS%REACTOME%R-HSA-174143.1 APC C-mediated degradation of cell cycle proteins CCNA1 CDK2 SKP2 FZR1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 BTRC ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 SKP1 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 FBXO5 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 AURKA PSMB6 PSMB7 PSMB4 CCNB1 PSMB5 PSMB2 UBB RB1 PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 CDC14A PSMB9 RPS27A SEM1 PTTG1 AURKB PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 CDK1 CCNA2 SUMOYLATION OF TRANSCRIPTION COFACTORS%REACTOME%R-HSA-3899300.5 SUMOylation of transcription cofactors CREBBP PARK7 CBX8 DDX5 CBX4 DDX17 CBX2 PIAS1 PHC2 PHC1 MRTFA BMI1 RING1 SUMO1 CTBP1 SUMO3 SUMO2 NRIP1 PPARGC1A PHC3 ZNF131 NPM1 SAFB ING2 TRIM28 UHRF2 CASP8AP2 MBD1 NCOA1 NCOA2 EP300 TOPORS ZNF350 DAXX HIPK2 SIN3A NCOR2 RNF2 PCGF2 PIAS4 PIAS3 UBE2I ANTAGONISM OF ACTIVIN BY FOLLISTATIN%REACTOME DATABASE ID RELEASE 76%2473224 Antagonism of Activin by Follistatin FSTL3 FST INHBB INHBA LATE PHASE OF HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 76%162599 Late Phase of HIV Life Cycle NUP42 VTA1 rev NUP43 gag-pol RAE1 vif RANBP2 NMT2 vpr vpu RAN NUP35 CHMP2B NUP37 CHMP2A NEDD4L env CHMP3 VPS37C VPS37D VPS37A CHMP6 VPS37B CHMP7 CHMP5 VPS4B VPS4A MVB12B MVB12A UBA52 XPO1 RANGAP1 NCBP1 NUP214 NCBP2 UBB UBC RPS27A CCNK CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP nef NELFE SUPT16H GTF2A1 ELOA3P VPS28 tat GTF2A2 GTF2B ELOA2 TAF9 SSRP1 CDK9 TAF1L CCNH GTF2E1 GTF2E2 RNMT TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 CCNT2 TAF4B PDCD6IP POLR2I POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 RNGTT TAF3 GTF2H1 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 RCC1 TBP ERCC2 MNAT1 SEC13 NUP107 NUP188 FURIN NUP210 NUP93 PPIA POM121 NUP205 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 UBAP1 CHMP4C CHMP4B CHMP4A NMT1 NUP62 gag NDC1 TSG101 NUP133 RANBP1 TCEA1 NUP50 NUP54 G PROTEIN GATED POTASSIUM CHANNELS%REACTOME%R-HSA-1296059.2 G protein gated Potassium channels KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 GABBR2 GABBR1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 RUNX2 REGULATES GENES INVOLVED IN DIFFERENTIATION OF MYELOID CELLS%REACTOME DATABASE ID RELEASE 76%8941333 RUNX2 regulates genes involved in differentiation of myeloid cells CBFB RUNX1 LGALS3 SIGNALLING TO P38 VIA RIT AND RIN%REACTOME%R-HSA-187706.2 Signalling to p38 via RIT and RIN NGF BRAF RIT1 RIT2 NTRK1 RHO GTPASES ACTIVATE FORMINS%REACTOME%R-HSA-5663220.1 RHO GTPases Activate Formins PPP2R1B PPP2R5E NUP43 RANBP2 MRTFA DIAPH1 DAAM1 PPP2R5B CDCA8 ITGB1 PPP2R5A SKA1 PPP2R5D SKA2 PPP2R5C NUP37 NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU PPP2R1A CENPH CENPI TAOK1 CDC42 CENPK CENPL CENPM CENPN DYNLL2 CENPO CENPP CENPQ CENPS DYNLL1 SRGAP2 CKAP5 CLIP1 KIF18A MAD1L1 MAPRE1 DVL1 NDC80 DVL3 PAFAH1B1 DIAPH3 DYNC1I2 SPDL1 XPO1 ACTG1 CENPF RANGAP1 SRF NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 RAC1 NDE1 DSN1 PLK1 SCAI RCC2 ZWINT EVL AHCTF1 ZW10 NDEL1 KIF2A RHOD KIF2C MIS12 KIF2B RPS27 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L CENPE PFN1 ZWILCH PFN2 RHOC KNTC1 RHOB SGO1 SGO2 PMF1 ACTB BUB1B BUB3 SEC13 MAD2L1 BUB1 NUP107 FMNL3 FMNL1 FMNL2 DYNC1I1 BIRC5 ITGB3BP NUP160 NUP85 CLASP2 NUP133 RHOA DVL2 ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING%REACTOME%R-HSA-451326.3 Activation of kainate receptors upon glutamate binding PLCB3 PLCB1 PLCB2 GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 DLG1 NCALD DLG3 GNG10 DLG4 GRIK5 GRIK4 GRIK1 GNG12 GRIK2 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GRIK3 GNGT2 CALM1 RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2+%REACTOME%R-HSA-76005.2 Response to elevated platelet cytosolic Ca2+ PRKCB FN1 ACTN1 LEFTY2 F8 BRPF3 VCL APP PECAM1 THBS1 GAS6 PDGFB CYB5R1 HGF A1BG FLNA SOD1 SERPINA3 CALM1 ABCC4 POTEKP ISLR HABP4 FAM3C CHID1 SERPINF2 PRKCG ACTN4 GTPBP2 SYTL4 TMX3 CD109 SELENOP TAGLN2 NHLRC2 TEX264 EGF TUBA4A STXBP2 ENDOD1 APOH VTI1B ITGA2B RARRES2 CYRIB LAMP2 MANF PPBP SELP SCCPDH MAGED2 HRG FERMT3 LGALS3BP ECM1 WDR1 PLEK CFL1 OLA1 CTSW SERPINA4 TMSB4X TIMP3 PRKCA PHACTR2 SRGN ANXA5 VEGFB MMRN1 TOR4A PCDH7 VEGFC ITIH4 VEGFD ITIH3 CLEC3B VEGFA CDC37L1 LY6G6F LHFPL2 PCYOX1L ITGB3 SERPINE1 TGFB2 TGFB3 STXBP3 A2M TTN TLN1 PFN1 ACTN2 HSPA5 ORM1 RAB27B ORM2 CD36 TF TIMP1 CAP1 ALDOA SERPINA1 CD63 IGF1 IGF2 PLG PROS1 F13A1 APOA1 FGB PF4 FGA APLP2 PPIA VWF SCG3 FGG CLU F5 CD9 APOOL SERPING1 CALU STX4 QSOX1 AHSG ALB KNG1 CFD SPARC TGFB1 PSAP SPP2 CELL JUNCTION ORGANIZATION%REACTOME%R-HSA-446728.2 Cell junction organization ACTN1 PATJ CTNNA1 CLDN2 CLDN1 CDH9 CTNNB1 CDH8 CDH7 CDH6 ITGB1 CDH3 LAMC2 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 JUP CLDN7 FBLIM1 CDH24 CADM2 SDK1 VASP SDK2 CLDN22 CLDN20 CLDN23 PRKCI CLDN5 ANG CLDN11 CLDN10 CLDN15 CLDN14 CDH10 CLDN12 CDH11 CLDN19 CDH12 CLDN18 CDH13 CLDN17 CLDN16 CDH17 CDH18 FLNA PARD6G PARD6B CTNND1 FLNC MPP5 CDH4 LIMS2 CRB3 LAMA3 CDH15 LAMB3 CDH2 DST CDH5 PXN ARHGEF6 TESK1 PARVB RSU1 ILK FERMT2 LIMS1 PARVA CDH1 ITGB4 CADM3 CADM1 ITGA6 NECTIN4 PLEC NECTIN3 PVR CD151 NECTIN2 NECTIN1 F11R COL17A1 PARD6A PARD3 RETINOID METABOLISM AND TRANSPORT%REACTOME%R-HSA-975634.2 Retinoid metabolism and transport GPC5 APOA1 GPC4 APOA4 LRP2 GPC6 SDC1 AGRN LPL APOE LDLR GPIHBP1 APOC3 LRP8 LRP1 RETSAT PLB1 APOC2 TTR APOM RDH11 APOB LRAT BCO2 AKR1C1 BCO1 RBP4 AKR1C3 CLPS AKR1B10 RBP2 AKR1C4 RBP1 LRP10 PNLIP LRP12 HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 APOA2 TRNA AMINOACYLATION%REACTOME DATABASE ID RELEASE 76%379724 tRNA Aminoacylation LARS2 PPA2 TARS2 AARS2 HARS2 AARS1 QARS1 FARS2 HARS1 YARS1 WARS1 IARS1 GARS1 NARS1 PPA1 FARSA CARS1 TARS1 EEF1E1 FARSB YARS2 VARS1 NARS2 RARS2 LARS1 CARS2 VARS2 KARS1 MARS2 DARS2 SARS2 IARS2 WARS2 MARS1 DARS1 SARS1 AIMP1 AIMP2 RARS1 EPRS1 PARS2 EARS2 METABOLISM OF SEROTONIN%REACTOME%R-HSA-380612.3 Metabolism of serotonin MAOA ALDH2 ION CHANNEL TRANSPORT%REACTOME DATABASE ID RELEASE 76%983712 Ion channel transport ATP2A1 ATP6V1G3 ATP6V0E2 TRPC7 PDZD11 FKBP1B TRPC6 TRPC3 ATP1B3 ATP1B2 TTYH3 ATP1B1 TTYH2 TRPC4AP ATP6V1H SCNN1G SCNN1D CLCNKB SCNN1B NEDD4L SCNN1A CLCNKA ATP6V1A SRI NALCN ASIC4 ASIC5 ASIC2 ATP6V1D ASIC3 ATP2B4 ATP6V1F SGK1 ATP2B3 ASIC1 ATP2B2 TRPV2 FXYD4 TRPV3 ATP2B1 TRPV1 FXYD3 TRPV6 FXYD2 TRPV4 FXYD1 TRPV5 FXYD7 FXYD6 CALM1 ATP6AP1 TRDN ATP6V1B2 ATP6V1B1 STOML3 ATP1A4 ATP1A3 ATP1A2 ANO10 ATP1A1 ATP2C2 SLC17A3 CLCN3 WWP1 ATP2C1 CLCN2 OSTM1 ATP8A2 ATP8A1 BEST2 CLCN1 ATP12A SLC9C1 BEST3 UBA52 STOM SLC9C2 BEST1 ATP13A1 BEST4 SLN CLCN7 CLCN6 CLCN5 CLCN4 ATP13A4 ATP13A5 ATP13A2 UBB CAMK2B CAMK2D UBC ATP11C CAMK2A ATP11B ATP11A RPS27A SLC9B1 SLC9B2 CAMK2G CLCA2 CLCA1 CLCA4 ATP8B4 ATP8B3 ATP8B2 ATP8B1 TCIRG1 UNC80 ATP7B TRPC5 TRPC4 TRPC1 ASPH ATP10D ATP10B ATP10A PLN BSND ATP9B ATP9A MCOLN3 TRPA1 CLCA3P MCOLN1 MCOLN2 TPCN2 TPCN1 UNC79 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6V0D1 ATP6V0D2 WNK4 TRPM1 TRPM2 ATP6V0A2 ATP6V0A4 TRPM7 TRPM8 TRPM5 TRPM6 ATP6V1C1 TRPM3 ATP6V0A1 ATP6V1C2 TRPM4 ATP4B ATP4A WNK1 ATP7A WNK2 WNK3 CUTC RYR1 RYR2 RYR3 CLIC2 ATP6V0B RAF1 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 ATP6V0C ATP2A3 SGK2 ATP2A2 INACTIVATION OF APC C VIA DIRECT INHIBITION OF THE APC C COMPLEX%REACTOME DATABASE ID RELEASE 76%141430 Inactivation of APC C via direct inhibition of the APC C complex CDC20 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 TOLL-LIKE RECEPTOR CASCADES%REACTOME DATABASE ID RELEASE 76%168898 Toll-like Receptor Cascades GSDMD TAB1 UBE2V1 PPP2R1B MAP2K6 CASP8 RIPK1 FADD PPP2R5D APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DNM1 DNM2 PPP2CA CD180 PPP2CB LY86 DNM3 LBP APOB PTPN11 PPP2R1A BTRC RIPK3 NFKB1 NKIRAS1 SKP1 NKIRAS2 MAPK8 TLR3 NFKBIB TLR8 FBXW11 CNPY3 LGMN EEA1 UBA52 MAP2K1 CUL1 DUSP4 DUSP3 VRK3 DUSP6 UBB DUSP7 MAPK7 MAPKAPK2 UBC JUN ITGAM ITGB2 RPS27A CREB1 MAPK14 MAPK11 RBSN ATF2 GSDME FOS S100A1 CTSS HMGB1 TIRAP mip BTK UNC93B1 porB TLR6 CTSL CD36 CTSK TANK PELI1 CTSB UBE2D2 UBE2D3 TBK1 IKBKE UBE2D1 IRF3 TRAF3 SOCS1 TLR7 fliC TLR10 IRAK4 TLR5 SAA1 MYD88 TICAM2 LY96 FGB FGA TICAM1 CD14 TLR4 IRF7 FGG HSP90B1 BIRC2 BIRC3 PTPN4 ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR IKBKB MAPKAPK3 MAP2K7 PIK3R4 ECSIT CHUK TNIP2 NFKBIA IRAK3 PELI3 RELA PELI2 NFKB2 IKBKG MAPK9 MAP3K1 MAPK10 TLR1 BPI S100A9 S100A8 NOD1 TLR2 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 TLR9 PIK3C3 S100B TRAF6 UBE2N PLCG2 TAB3 MAP3K7 TAB2 DEFECTIVE SLC1A1 IS IMPLICATED IN SCHIZOPHRENIA 18 (SCZD18) AND DICARBOXYLIC AMINOACIDURIA (DCBXA)%REACTOME%R-HSA-5619067.1 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) SLC1A1 TRANSLOCATION OF SLC2A4 (GLUT4) TO THE PLASMA MEMBRANE%REACTOME%R-HSA-1445148.2 Translocation of SLC2A4 (GLUT4) to the plasma membrane STXBP3 RAB4A ASPSCR1 MYO5A SLC2A4 SNAP23 KIF3A YWHAQ SFN YWHAH C2CD5 LNPEP TBC1D1 PRKAB2 YWHAE TBC1D4 PRKAA2 PRKAG1 KIFAP3 PRKAG2 PRKAB1 MYH9 PRKAG3 RHOQ RALA RAB8A YWHAG CALM1 EXOC8 EXOC7 KIF3B EXOC4 EXOC3 RAB11A EXOC6 EXOC5 EXOC2 VAMP2 RAB10 EXOC1 MYO1C RAB14 YWHAB RAB13 AKT2 AKT1 STX4 YWHAZ RALGAPA2 RALGAPB RAC1 DEFECTIVE INHIBITION OF DNA RECOMBINATION AT TELOMERE DUE TO DAXX MUTATIONS%REACTOME%R-HSA-9670613.1 Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations DAXX ATRX TIGHT JUNCTION INTERACTIONS%REACTOME%R-HSA-420029.1 Tight junction interactions PATJ CLDN2 CLDN1 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 CLDN7 CLDN22 CLDN20 CLDN23 PRKCI CLDN5 CLDN11 CLDN10 CLDN15 CLDN14 CLDN12 CLDN19 CLDN18 CLDN17 CLDN16 PARD6G PARD6B MPP5 CRB3 F11R PARD6A PARD3 FORMATION OF APOPTOSOME%REACTOME%R-HSA-111458.3 Formation of apoptosome XIAP MAPK1 AVEN CASP9 APAF1 DIABLO MAPK3 APIP UACA CARD8 CYCS CALNEXIN CALRETICULIN CYCLE%REACTOME%R-HSA-901042.2 Calnexin calreticulin cycle DERL2 RNF5 OS9 RNF139 SEL1L UGGT2 UGGT1 MARCHF6 UBA52 EDEM3 PDIA3 EDEM1 AMFR RNF103 PRKCSH TRIM13 CALR SYVN1 GANAB UBB UBC RNF185 RPS27A EDEM2 CANX MAN1B1 ADENOSINE P1 RECEPTORS%REACTOME%R-HSA-417973.1 Adenosine P1 receptors ADORA3 ADORA2A ADORA2B ADORA1 NA+ CL- DEPENDENT NEUROTRANSMITTER TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%442660 Na+ Cl- dependent neurotransmitter transporters SLC6A20 SLC6A5 SLC6A19 SLC6A18 SLC6A14 SLC6A2 SLC6A3 SLC6A6 SLC6A9 SLC6A12 SLC6A11 SLC22A2 SLC22A1 SLC6A1 SLC6A7 SLC18A1 SLC18A2 SLC6A15 SLC6A13 FRUCTOSE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%5652227 Fructose biosynthesis SORD AKR1B1 BETA OXIDATION OF HEXANOYL-COA TO BUTANOYL-COA%REACTOME DATABASE ID RELEASE 76%77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA HADHB HADH HADHA ECHS1 ACADS TRANSCRIPTION-COUPLED NUCLEOTIDE EXCISION REPAIR (TC-NER)%REACTOME%R-HSA-6781827.1 Transcription-Coupled Nucleotide Excision Repair (TC-NER) POLD2 ELL XRCC1 POLE4 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RBX1 PCNA CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RFC5 GTF2H1 GTF2H2 RFC3 RFC4 GTF2H3 EP300 RFC2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RPA1 RPA2 RPA3 GPS1 UBA52 COPS4 COPS2 ERCC6 UBB UBC POLK ISY1 POLE RPS27A PRPF19 HMGN1 LIG1 USP7 AQR RFC1 DDB1 PPIE ZNF830 XPA LIG3 COPS7B COPS7A CUL4A COPS3 XAB2 COPS6 COPS5 UVSSA ERCC8 TCEA1 COPS8 POLD3 CUL4B POLD4 POLD1 LESTAURTINIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702596 lestaurtinib-resistant FLT3 mutants FLT3 DEFECTIVE SLC17A5 CAUSES SALLA DISEASE (SD) AND ISSD%REACTOME DATABASE ID RELEASE 76%5619035 Defective SLC17A5 causes Salla disease (SD) and ISSD SLC17A5 SDK INTERACTIONS%REACTOME DATABASE ID RELEASE 76%373756 SDK interactions SDK1 SDK2 CLASS I PEROXISOMAL MEMBRANE PROTEIN IMPORT%REACTOME%R-HSA-9603798.2 Class I peroxisomal membrane protein import FIS1 PEX26 PEX3 ACBD5 PEX19 PXMP4 PEX16 ATAD1 PEX12 ABCD1 GDAP1 ABCD2 PEX11B ABCD3 PEX13 PEX14 PEX2 PXMP2 SLC25A17 NUCLEAR SIGNALING BY ERBB4%REACTOME DATABASE ID RELEASE 76%1251985 Nuclear signaling by ERBB4 PSEN1 PSENEN NRG1 NRG2 NRG3 NCSTN ESR1 NRG4 CXCL12 PGR HBEGF APOE STAT5A PSEN2 APH1A APH1B GFAP NCOR1 SPARC CSN2 WWOX STMN1 ADAP1 ADAM17 MXD4 EREG BTC YAP1 S100B SRC TAB2 REVERSE TRANSCRIPTION OF HIV RNA%REACTOME DATABASE ID RELEASE 76%162589 Reverse Transcription of HIV RNA gag rev gag-pol vif PPIA vpr vpu ACTIVATION OF RAS IN B CELLS%REACTOME DATABASE ID RELEASE 76%1169092 Activation of RAS in B cells RASGRP3 HRAS NRAS RASGRP1 POST-TRANSCRIPTIONAL SILENCING BY SMALL RNAS%REACTOME DATABASE ID RELEASE 76%426496 Post-transcriptional silencing by small RNAs TNRC6A AGO3 TNRC6B AGO4 AGO1 AGO2 TNRC6C LISTERIA MONOCYTOGENES ENTRY INTO HOST CELLS%REACTOME DATABASE ID RELEASE 76%8876384 Listeria monocytogenes entry into host cells SH3KBP1 UBB EPS15 SH3GL2 UBC SH3GL1 HGS CDH1 RPS27A CTNNB1 CTNND1 inlA STAM2 CBLL1 UBA52 MET STAM SH3GL3 inlB CBL SRC 2-LTR CIRCLE FORMATION%REACTOME%R-HSA-164843.2 2-LTR circle formation BANF1 rev gag-pol vif vpr PSIP1 vpu gag XRCC4 XRCC6 XRCC5 LIG4 HMGA1 METABOLISM OF WATER-SOLUBLE VITAMINS AND COFACTORS%REACTOME%R-HSA-196849.3 Metabolism of water-soluble vitamins and cofactors PDZD11 CYB5R3 SHMT2 GSTO2 GSTO1 NT5E TCN1 SLC2A3 ABCC1 BTD MTRR PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 TCN2 PARP8 PRSS1 SHMT1 CD320 CTRB2 CTRB1 SLC23A2 SLC23A1 NADSYN1 PNPO SLC19A3 NADK SLC19A2 ACACB NAMPT CTRC MOCS2 MOCS3 QPRT GPHN THTPA NADK2 NMRK2 NAXE NMRK1 RNLS SLC22A13 CD38 AOX1 NAXD NUDT12 SLC25A19 CYB5A TPK1 MOCOS BST1 NMNAT3 NMNAT2 NMNAT1 PTGS2 PTGIS PANK4 PANK2 PANK3 PANK1 PPCDC COASY SLC46A1 SLC5A6 SLC25A16 CYP8B1 VNN1 VNN2 PPCS FASN ENPP2 MMAB ENPP1 ENPP3 AASDHPPT CUBN MMADHC AMN NNMT MMAA MMUT LMBRD1 DHFR2 ALDH1L1 MTHFR MTHFS ALDH1L2 DHFR MTHFD1L MTHFD1 MTHFD2 MTHFD2L MCCC2 SLC25A32 PC FOLR2 PRSS3 SLC19A1 PCCA HLCS MTR NAPRT MCCC1 PCCB ACACA PDXK ABCD4 SLC2A1 MMACHC SLC5A8 FLAD1 CBLIF SLC52A2 RFK SLC52A3 ACP5 SLC52A1 ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS%REACTOME%R-HSA-983695.4 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGHV3-53 IGLC7 IGKV2D-40 IGHV3-11 IGKV5-2 IGLC6 IGHV3-13 IGHV1-46 SOS1 IGHV TRPC1 SYK STIM1 FYN BTK ORAI2 ORAI1 VAV1 IGLV3-19 ITPR1 ITPR2 ITPR3 SH3KBP1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-5 PIK3R1 IGLV PTPN6 CALM1 IGKV1D-39 NCK1 IGKV1D-33 PIK3AP1 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 DAPP1 IGLV2-14 CD79B IGLV1-44 CD79A IGKV3-15 IGKV3-11 CD22 IGHM BLNK IGHD AHCYL1 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN IGHV3-23 IGLV1-51 IGLV2-23 IGLV2-8 IGKV3-20 IGHV4-34 IGKV1-16 IGHV1-2 IGHV4-39 IGKV1-17 IGKV1-12 IGHV3-7 IGKV2-29 IGHV3-9 IGKV2-28 IGLC3 IGHV3-30 IGLC1 IGLC2 IGHV3-33 PIK3CD BLK IGKV2D-28 IGKV4-1 IGHV7-81 IGKV3D-20 IGKV2D-30 IGKV2-30 IGHV2-70 IGHV2-5 IGHV1-69 IGHV3-48 IGLV3-1 IGKV1-39 PLCG2 CD19 IGKV1-33 RNA POLYMERASE II TRANSCRIPTION ELONGATION%REACTOME%R-HSA-75955.2 RNA Polymerase II Transcription Elongation CTDP1 RTF1 ELL MLLT3 CCNT1 SUPT6H SUPT4H1 IWS1 ELOA3DP LEO1 ELOA EAF1 NELFB EAF2 ELOB PAF1 ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 NCBP1 NCBP2 CCNK TCEA1 AFF4 CDC73 CTR9 WDR61 MLLT1 GLUCONEOGENESIS%REACTOME DATABASE ID RELEASE 76%70263 Gluconeogenesis FBP1 GAPDH SLC25A11 GPI FBP2 PCK2 SLC37A1 MDH1 PGK2 MDH2 G6PC2 ENO1 ALDOB GOT1 GOT2 PGK1 GAPDHS PC SLC25A1 ALDOC ALDOA SLC37A4 G6PC3 SLC25A10 SLC25A12 PCK1 SLC25A13 G6PC1 ENO2 ENO3 PGAM1 TPI1 PGAM2 DISEASES OF MISMATCH REPAIR (MMR)%REACTOME DATABASE ID RELEASE 76%5423599 Diseases of Mismatch Repair (MMR) MSH3 MSH6 PMS2 MSH2 MLH1 TRKA ACTIVATION BY NGF%REACTOME%R-HSA-187042.1 TRKA activation by NGF NGF NTRK1 DEFECTIVE ALG8 CAUSES ALG8-CDG (CDG-1H)%REACTOME DATABASE ID RELEASE 76%4724325 Defective ALG8 causes ALG8-CDG (CDG-1h) ALG8 GAP-FILLING DNA REPAIR SYNTHESIS AND LIGATION IN TC-NER%REACTOME DATABASE ID RELEASE 76%6782210 Gap-filling DNA repair synthesis and ligation in TC-NER POLD2 XRCC1 POLE4 POLE2 POLE3 RBX1 PCNA CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RFC5 GTF2H1 GTF2H2 RFC3 RFC4 GTF2H3 EP300 RFC2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RPA1 RPA2 RPA3 UBA52 ERCC6 UBB UBC POLK ISY1 POLE RPS27A PRPF19 HMGN1 LIG1 USP7 AQR RFC1 DDB1 PPIE ZNF830 LIG3 CUL4A XAB2 UVSSA ERCC8 TCEA1 POLD3 CUL4B POLD4 POLD1 DEFECTIVE CYP11B2 CAUSES CMO-1 DEFICIENCY%REACTOME DATABASE ID RELEASE 76%5579009 Defective CYP11B2 causes CMO-1 deficiency CYP11B2 INTRACELLULAR OXYGEN TRANSPORT%REACTOME%R-HSA-8981607.2 Intracellular oxygen transport NGB MB CYGB BIOTIN TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 76%196780 Biotin transport and metabolism PCCB ACACA SLC5A6 PDZD11 MCCC2 PC PCCA HLCS BTD MCCC1 ACACB TRANSLATION OF STRUCTURAL PROTEINS%REACTOME%R-HSA-9694635.1 Translation of structural proteins ST3GAL3 3a SUMO1 ST6GALNAC2 RPN2 PRKCSH TUSC3 RPN1 MAGT1 FUT8 GANAB S MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS M DDOST MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 GALNT1 PARP10 PARP6 GSK3B PARP4 PARP16 PARP9 UBA52 PARP14 N PARP8 E UBB UBC RPS27A UBE2I DEFECTIVE ACTH CAUSES OBESITY AND POMCD%REACTOME%R-HSA-5579031.4 Defective ACTH causes obesity and POMCD MC2R POMC DEFECTIVE CSF2RA CAUSES SMDP4%REACTOME DATABASE ID RELEASE 76%5688890 Defective CSF2RA causes SMDP4 SFTPA2 SFTPA1 SFTPC CSF2RB SFTPB SFTPD CSF2RA SFTA3 DEFECTIVE GALNT3 CAUSES FAMILIAL HYPERPHOSPHATEMIC TUMORAL CALCINOSIS (HFTC)%REACTOME DATABASE ID RELEASE 76%5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) MUC4 MUC6 MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 GALNT3 MUC19 MUC20 MUC21 MUCL1 MUC5B MUC5AC MUC1 MUC2 MUC13 MUC7 SCF(SKP2)-MEDIATED DEGRADATION OF P27 P21%REACTOME%R-HSA-187577.3 SCF(Skp2)-mediated degradation of p27 p21 CCNA1 CCNE2 CCNE1 CDK2 SKP2 SKP1 CKS1B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 CCND1 RPS27A SEM1 PSMC5 CDK4 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 CDKN1A CDKN1B CCNA2 SHC1 EVENTS IN EGFR SIGNALING%REACTOME%R-HSA-180336.2 SHC1 events in EGFR signaling HBEGF HRAS AREG SHC1 TGFA EGFR EREG BTC SOS1 NRAS EGF EPGN GENERIC TRANSCRIPTION PATHWAY%REACTOME DATABASE ID RELEASE 76%212436 Generic Transcription Pathway CREBBP CSF2 CBFB PRKCB RUNX1 IHH MAPK1 BGLAP MAPK3 MYL9 ITGA2B PLXNA4 ITGA5 MET CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 GRIN2B H2AX EHMT2 H2AB1 H2AC19 CHD4 CHD3 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 CHEK1 H2AJ KAT2A H2BC15 H2BC11 HDAC2 HDAC1 H3C15 RBBP4 H2BS1 RBBP7 MTA2 LDB1 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 CBX3 H2BC3 H2BC1 DEK GATAD2B GATAD2A H2AC20 CASP10 HNF4G HDAC3 GCK CSNK2A1 CSNK2A2 CSNK2B NFKB1 MEN1 FKBP5 NOTCH2 NOTCH3 NOTCH4 TNFRSF10B TNFRSF10A YES1 TNFRSF10D VEGFA DAXX BLK ELF1 ELF2 PAX5 GPAM AGO3 AGO4 AGO1 AGO2 SKP2 FZR1 FASLG FAS SOCS3 PTPN1 PRKAA1 FOXO1 RPTOR STK11 AKT2 MLST8 SLC38A9 TSC2 TSC1 MTOR PPM1A RRAGA RRAGC RHEB RRAGB OCLN RRAGD LAMTOR2 LAMTOR1 LAMTOR4 LAMTOR3 LAMTOR5 IRAK1 COL1A1 NOP2 HSPD1 TFAP2A TFAP2B TFAP2C CGB8 ATAD2 YY1 KIT MEF2C STAT1 LBR PPARD CEBPB SPI1 TAL1 DDIT3 KMT2A CDC25C HDAC6 TPX2 MYBL2 JAG1 CAV1 PML RB1 CCND3 TFDP1 CDK6 CCND2 TFDP2 CCND1 CDK4 E2F1 MAML2 MAML1 RBPJ ITGAL MYC CCN2 TEAD1 TEAD2 TEAD3 TEAD4 BRD2 ITGA4 RUNX3 ATF2 MAML3 YAP1 NOTCH1 SRC TCF7 SERPINE1 LEF1 FOXO3 BCL2L11 HES1 SIRT1 WWTR1 TCF7L2 SMAD4 TCF7L1 ZFHX3 SMAD3 SMURF2 SNW1 CTNNB1 KRAS MAMLD1 PPARGC1A TAF9 TAF1L NR1D1 TAF7L TAF9B TAF15 TAF12 TAF13 TAF10 TAF11 TAF7 TAF4B TAF6 TAF5 USP2 TAF4 TAF3 TAF2 TAF1 UBE2D3 PIN1 CASP2 GP1BA MED1 SREBF1 SMARCD3 TBL1XR1 FOXO6 CARM1 NR4A1 TBL1X MRE11 TP53RK EHMT1 PRDM1 NOC2L KAT5 PIP4K2A PIP4K2B NBN KMT5A PIP4K2C TP63 HUS1 KAT6A MAPKAPK5 DNA2 RHNO1 L3MBTL1 BLM MEAF6 PPP2R1B MAPKAP1 BRIP1 NUAK1 SMYD2 TP53BP2 ATRIP BANP MAP2K6 TRPC3 BARD1 PLK3 BRPF1 BRPF3 JMY RAD17 PPP2R5C RAD9B TP73 ATR RAD9A PRR5 DYRK2 PPP1R13B SETD9 BRCA1 ING5 ING2 PIP4P1 EXO1 PPP1R13L PPP2CA TOPBP1 RFC5 PPP2CB PRMT5 RMI2 BRD1 RFC3 RFC4 RFC2 RMI1 PDPK1 TOP3A SGK1 RNF34 WRN PTPN11 TP53INP1 RBBP8 RICTOR RFFL BRD7 RPA1 RPA2 HIPK1 POU4F1 POU4F2 RAD50 TTC5 CALM1 RPA3 CCNG1 RAD1 CDK5R1 GLS GAMT EZH2 SIN3B EED SUZ12 JUN SOD2 PRDX2 PRDX1 RAD51D RAD51 MDC1 CCNK MT-CO1 TP53AIP1 COX7A2L SCO1 SCO2 DDIT4 MT-CO2 MT-CO3 TXN PRELID3A PRELID1 SURF1 CRADD GADD45A PLK2 CDK12 CDK13 GPI BTG2 COX7B COX7C BBC3 AIFM2 TNKS1BP1 COX8A CNOT6L PRMT1 FOS DDB2 PCNA COX5B COX5A PLAGL1 BDNF PERP PMS2 BID TIGAR NPM1 MLH1 COX6C LRPPRC STEAP3 CCNT2 TACO1 COX6A1 SESN3 SESN2 BNIP3L G6PD IGFBP3 COX6B1 MSH2 FANCD2 COX19 COX16 COX18 NDRG1 PMAIP1 COX11 COX14 BCL2L14 ZNF420 FANCI TNFRSF10C CNOT10 FANCC CNOT4 CNOT6 RGCC CNOT7 TP53I3 BCL6 CNOT1 CNOT11 CNOT2 CNOT3 CYCS CNOT8 CNOT9 COX20 COX4I1 PTEN TRIAP1 PIDD1 CASP6 CASP1 APAF1 RABGGTB RABGGTA RBL2 RBL1 RRM2B TMEM219 BIRC5 NLRC4 E2F4 E2F7 E2F8 NDUFA4 ARID3A BAX NPPA TBX5 NKX2-5 HDAC10 HDAC11 TXNIP CCNC GLS2 HEY1 HEY2 TXNRD1 ERBB2 MYB YWHAE ESR2 CDK8 PPP2R1A ZFPM1 PRKACA HDAC5 GATA4 GATA3 YWHAG HDAC8 HDAC9 GATA2 SKP1 DLL1 GATA1 HDAC7 ABL1 NFE2 CBX5 CDK5 UBA52 CUL1 AURKA IL6 CCNB1 UBB UBC RPS27A SIN3A CENPJ CRH CDK1 CR1 HDAC4 UBE2I THRB VDR NR1H2 RORA NR3C1 NR2C1 ESR1 NR4A2 NR5A1 AR RXRA SUMO1 RARA PPARG PGR PPARA CCNH POLR2A POLR2B POLR2C POLR2D GRIA2 POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J GRIN2A POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 STUB1 ANAPC15 ANAPC16 BTG1 ANAPC7 MSTN UBE2C CITED2 UBE2E1 IGFBP1 UBE2D1 TRIM63 SIRT3 ANAPC10 CAT ANAPC11 CDC23 RETN PCK1 UBE2S CDC26 KLF4 FBXO32 CDC16 G6PC1 CDC27 ANAPC4 PINK1 ANAPC5 CCNG2 AGRP ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 APOE PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 USP7 PSMC4 PSMC1 PSMC2 TCEA1 SMAD2 TNFRSF18 GPX2 ZNF287 ZNF17 ZNF18 ZNF19 ZNF285 RBFOX1 ZNF282 NEDD4L ZNF10 ZNF12 ZNF14 CLDN5 ZNF28 ZNF274 ZNF273 ZNF20 ZNF23 ZNF25 ZNF26 ZNF268 ZNF267 ABCA6 PPARGC1B ZNF266 ZNF264 ZNF263 NR2F1 ZNF34 NR0B2 NR2F6 ZNF30 ZNF257 ZNF256 ZNF254 ZNF496 ZNF253 ZNF493 ZNF250 ZNF492 UCMA ZNF490 ZNF43 ZNF45 MED16 MED15 MED17 MED12 MED14 MED13 MED10 ZNF41 CTLA4 ZNF248 ZNF486 ZNF485 ZNF484 ZNF483 ACTL6B RING1 WWP1 ZNF480 CGA MED27 MED26 MED23 MED25 MED24 MED20 ZNF479 ZNF235 ZNF234 ZNF233 ZNF473 ZNF230 SERPINB13 ZNF471 ZNF470 ZNF227 ZNF226 ZNF468 ZNF225 ZNF224 ZNF223 ZNF222 ZNF221 ZNF461 ZNF460 ZNF77 ZNF79 SKI ZNF70 ZNF71 ZNF74 ZNF699 ZNF215 ZNF214 ZNF697 ZNF213 ZNF696 ZNF454 ZNF212 ZNF211 ZNF692 ZNF691 RORC RORB ZNF208 ZNF689 ZNF205 ZNF688 ZNF446 PITX2 AKT3 ZNF445 ZNF202 ZNF443 ZNF684 ZNF442 ZNF200 ZNF441 ZNF682 ZNF440 ZNF681 ZNF680 ZFP69B FOXP3 MAF ZNF439 ZNF679 ZNF678 ZNF436 ZNF677 ZNF676 ZNF675 ZNF433 PVALB ZNF432 ZNF431 KMT2E ZNF430 SFN ZNF671 KMT2D ZNF670 DLX5 DLX6 KMT2C KMT2B ZNF840P MED30 MOBP ZKSCAN7 ZNF429 MED31 ZKSCAN8 ZNF669 NPY ZKSCAN3 ZNF668 ZNF426 ZNF667 ZNF425 ZKSCAN5 ZKSCAN4 ZNF665 ZNF664 SOCS4 ZKSCAN1 CHM ZNF662 ZNF660 ZNF419 ZNF418 ZNF417 ZNF658 ZNF416 ZNF415 ZNF655 SP7 ZNF649 DGCR8 YAF2 NKX3-2 ZNF641 HAND2 ZNF875 PPM1D ZNF627 PF4 ZNF626 ZNF625 ZNF624 ZNF621 E2F6 ZNF620 ZNF860 MGA ZNF619 IL2RA ZNF616 ZNF615 ZNF614 ZNF613 ZNF611 PTPN4 ZNF610 EGFR TRIM33 SMARCB1 UXT ZNF729 TRIM28 ZNF727 ZNF726 ZNF724 EPC1 ZNF721 ZNF720 SMARCC1 SMARCC2 ZFP1 ZFP2 ZNF718 ZNF717 ZNF716 ZNF714 ZNF713 ZNF711 ZNF710 KCTD15 ZNF324B L3MBTL2 ZNF709 ZNF708 ZNF707 ZNF706 ZNF704 ZNF703 ZNF701 ZNF700 HIVEP3 SMARCA2 SMARCA4 ITGBL1 BMI1 HNF4A PBRM1 SATB2 RXRB ZFP14 ZNF585B RXRG ZNF585A GAD1 GAD2 ZFP28 PRDM7 ARID2 MSX2 ZNF99 GPRIN1 TFAP2D TFAP2E AUTS2 IL2 IL3 BMP2 TCF3 DPY30 TGIF1 RBM14 ZNF75CP TGIF2 RNF2 OPRM1 RRM2 ZNF804B ZNF175 ZSCAN32 ZNF169 JUNB SLC2A3 ZNF705F ZNF705G ZNF705D ZNF705E ZNF160 MED8 ZNF705A MED4 MED6 MED7 ZSCAN25 ZNF157 ZNF398 ZNF155 ZNF154 ZNF394 NR2C2AP PHC2 PHC1 ZNF383 ZNF141 ZNF382 ZNF140 SETD1B SETD1A OPRK1 NFATC2 NR1D2 CDC7 PHC3 ZNF37A ZNF702P POMC ZNF138 SST ZNF136 ZNF135 ZNF133 RARG ASH2L RSPO3 ZNF124 ZIK1 TCF12 RARB ZNF599 ZNF114 ZNF597 ZNF112 ZNF596 ZNF595 RNF111 ZNF350 ZNF347 ZNF589 PARP1 ZNF587 ZNF586 ZIM2 ZNF343 ACTL6A ZIM3 ZNF101 ZNF100 ZNF584 WWOX ZNF583 PCGF6 CDKN2B ZNF582 PCGF5 PCGF2 ZNF33B ZNF33A RYBP ZNF337 ZNF577 ZNF334 ZNF333 ZNF331 ZNF573 ZNF571 ZNF570 YEATS4 ZFP30 TGFA ZNF569 ZNF568 ZNF567 ZNF324 ZNF566 ZFP37 ZNF565 ZNF564 ZNF563 ZNF562 ZNF320 ZNF561 ZNF560 NRBP1 ZNF559 ZNF317 ZNF558 CTSL ZNF557 ZNF799 CTSK ZNF556 ZNF555 ZNF554 ZNF311 ZNF552 ZNF551 ZNF793 ZNF550 CSF1R ZNF792 ZNF791 ZNF790 KRBA1 KRBOX4 ZNF767P ZNF549 ZNF548 ZNF547 ZNF546 ZNF304 ZNF544 MMP13 ZNF302 ZNF786 ZNF543 ZNF785 SKIL ZNF300 ZNF782 ESRRA ZNF540 ZNF658B IFNG ESRRB ESRRG ZFP69 ZNF778 ZNF777 SPP1 ZNF776 ZNF775 ZNF774 ZNF773 ZNF772 ZNF530 ZNF771 ZNF770 ZNF529 ZNF528 WDR5 ZNF764 TJP1 ZNF521 ZNF761 ZNF75D ZNF75A ZFP90 ZNF519 ZNF517 ZNF514 ZNF510 ZNF750 SMARCD1 SMARCD2 ZNF749 RBBP5 ZNF506 ZNF747 ZNF746 ZNF500 ZNF740 SMARCE1 ZNF738 ZNF737 ZNF736 ZNF735 ZNF732 ZNF730 SOX2 ZNF607 ZNF606 ZNF605 SOX9 ZNF600 ZNF839 TWIST2 TWIST1 ZNF726P1 CITED1 CITED4 VENTX PRMT6 ZNF2 ZNF3 ZNF354A ZNF354C ZNF354B LMO1 LMO2 KCTD1 ATP1B4 LIFR KCTD6 CBX8 CBX6 CBX4 CBX2 SMAD6 NR4A3 KDM5B THRA NR2E1 ARID1A ARID1B ZNF197 ZNF195 NR2C2 THBS1 YWHAQ ZNF286A ZNF189 ZNF184 YWHAH ZNF180 PRKAB2 PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 INS FOXO4 ATXN3 USP9X SMAD1 SMAD7 GSK3B AXIN1 YWHAB AKT1 YWHAZ CAMK2B CAMK2D FOXG1 CAMK2A GPS2 HTT AURKB CAMK2G HIPK2 NCOR2 TNRC6C MOV10 CREB1 NCOR1 CAMK4 TNRC6A TNRC6B MAPK14 MAPK11 PRKCQ CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 CCNA1 CCNE2 CCNE1 TP53 PCBP4 NFYA CDKN2A CDK2 MDM2 NFYB ATM NFYC MDM4 RBX1 SP1 MAX E2F5 GLI3 GLI2 ITCH RELA TGFB1 SMURF1 LGALS3 REGULATION OF GENE EXPRESSION IN LATE STAGE (BRANCHING MORPHOGENESIS) PANCREATIC BUD PRECURSOR CELLS%REACTOME%R-HSA-210744.2 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells CREBBP HES1 NEUROG3 EP300 SNW1 MAML2 MAMLD1 MAML1 RBPJ ONECUT3 ONECUT1 KAT2B KAT2A MAML3 HNF1B NOTCH1 METABOLISM%REACTOME%R-HSA-1430728.10 Metabolism CREBBP ENO1 PGK1 RAB5A KPNB1 CYP26A1 LPGAT1 PITPNB CYP27B1 CPNE7 CYP26B1 CPNE6 CYP24A1 MFSD2A CYP26C1 CYP2R1 STARD7 RUFY1 CYP2C9 CYP2C8 PLA1A CYP2D6 MTMR8 PLA2G3 CYP1A2 CYP2E1 MTMR9 CYP3A4 MTMR6 MTMR7 RPL4 PGS1 RPL5 RPL30 PTDSS2 RPL3 PTDSS1 RPL32 PTPMT1 RPL31 INPP5J RPL34 INPP5K RPLP1 TMEM86B STARD10 RPL10L RPLP0 PEMT RPL10A CDS2 DGAT2L7P RPL8 OSBPL10 RPL6 RPL7 TNFAIP8L1 RPS4X TNFAIP8L3 RPS15 TNFAIP8L2 PCYT1B RPL7A PCYT1A RPS14 RPS17 PLAAT1 RPS16 PLAAT3 RPL18A PLAAT2 RPS19 PLAAT5 RPS18 PLAAT4 RPL36AL PLEKHA1 PNPLA8 RPL36 PLEKHA2 RPL35 RPLP2 PLEKHA5 PLEKHA6 RPL38 PLEKHA3 RPL37 RPS11 PLEKHA4 PLEKHA8 RPL39 RPS10 LPCAT3 RPS13 LPCAT2 PNPLA3 RPS12 CACNB2 TPTE2 CACNB3 RPS9 ABHD4 RPS7 ABHD3 PLD4 RPL21 PLD3 OSBPL8 RPS8 OSBPL5 DGAT2L6 RPS5 CRLS1 RPL23 PI4KB RPL22 TNFAIP8 RPS6 PIK3C2G RPL13A PIK3C2B RPSA TPTE RPS3A AWAT2 RPL9P9 MBOAT7 RPL37A MBOAT1 RPL24 MBOAT2 RPL27 CHPT1 RPL26 RPL29 PIK3CD RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 PPA2 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 SRR PSAT1 PHGDH SERINC1 SERINC3 SERINC2 SERINC5 PSPH SERINC4 EP300 AKAP5 CACNA1D CACNA1C ALAS1 MT-ATP6 ATP5MC2 ATP5MC3 NRF1 ATP5MG ATP5MF ATP5ME DMAC2L ATP5PF ATP5PD ATP5PB IDH2 ATP5F1C ATP5F1D ATP5F1E MT-ATP8 ATP5PO SLC22A3 SLC22A5 GLO1 LDHC LDHB SLC22A2 LDHA SLC22A1 PDPR MPC1 MPC2 PDK4 ME1 PDK3 PDK2 PDK1 PDP1 PDP2 LDHAL6A LDHAL6B XDH HDAC3 CSNK2A1 CSNK2A2 CSNK2B GAPDHS GNG10 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 SPHK1 GBA GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 MAOA COMT SLC26A2 B4GALT1 SDC4 SDC2 HEXB SDC3 HEXA PRELP PAPSS2 GPC1 GPC3 GPC2 GPC5 GPC4 CHST14 GPC6 PFAS ATIC ST3GAL3 CHST6 GUK1 PPAT B3GAT3 TK2 LUM OMD NME2P1 NUDT13 KERA ADSL B3GALT6 EXT1 CAD EXT2 CTPS2 OGN NME3 SDC1 CTPS1 FMOD NME4 AGRN NME1 DCTD B4GALT7 CMPK1 UMPS GART DCTPP1 DTYMK AK1 AK2 GMPS AK4 GLRX AK5 AK6 AK7 AK8 AK9 LHPP RRM1 PAICS UCKL1 DHODH UCK2 ACBD5 UCK1 PUDP ADSS1 ADSS2 B4GALT2 PANK4 B4GALT3 PANK2 B3GNT7 PANK3 B3GNT4 PANK1 B3GNT3 CHST1 PPCDC COASY B3GNT2 SLC5A6 B4GALT6 CHST5 SLC25A16 VNN1 B4GALT4 CHST2 VNN2 PPCS B4GALT5 FASN ENPP2 ENPP1 ENPP3 AASDHPPT MMAA MMUT DHFR2 ALDH1L1 MTHFR MTHFS ALDH1L2 DHFR MTHFD1L STK11 MTHFD1 MTHFD2 MTHFD2L DHRS7B SLC25A32 FOLR2 SLC19A1 GYS1 GYG1 MAN2B2 MAN2C1 RGL1 BMX CEMIP STAB2 LYVE1 HAS1 HYAL2 HAS3 HAS2 CHP1 FBP1 SLC25A11 FBP2 PCK2 SLC37A1 MDH1 MDH2 G6PC2 PLCB4 PLD6 CPT2 MID1IP1 THRSP LBR SLC25A20 CPT1B PPARD OCRL PM20D1 PIK3R2 MLXIPL ADIPOQ ADIPOR1 ADIPOR2 CAV1 ESYT1 RHCE RHD GLYCTK ETFB HPSE2 XYLT2 XYLT1 SGSH IDS GUSB IDUA B3GAT2 B3GAT1 GLB1L MCCC2 HPSE PC PCCA INPP5D HLCS MCCC1 PCCB ACACA NCOA1 MED1 ECSIT NCOA2 CPT1A SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X ACSM5 ACSM4 AS3MT FDXR CYP1B1 FLAD1 CHAC2 SLC52A2 SULT2A1 GSTK1 RFK SLC52A3 CMBL ACP5 POR CYP2U1 SLC52A1 FDX1 FDX2 CES2 CES1 MAOB MTARC2 MTARC1 PPP2R1B MGST3 MGST1 PRKG2 MGST2 ADH7 ADH5 ADH6 SULT1A1 ADH4 CYB5R3 CYP2B6 GSTT2B SULT1A4 PLA2G4A SULT1A3 SULT1A2 PPP2R5D GSTM4 GSTM3 GLYATL3 GSTM2 GLYATL2 GSTM1 GLYATL1 CYP4F2 CYP4F3 CYP4F8 SULT1B1 ITPR1 CYP2S1 ITPR2 CYP1A1 ITPR3 GSTM5 ACY3 LRP8 ACY1 PPP2CA SULT1C2 PPP2CB SULT1C4 GSTO2 GSTO1 AKR1A1 UGDH CYP21A2 APOB AHRR NOS3 ADH1C ADH1B ADH1A GSTP1 PTGS1 SULT1E1 CYP2A13 CYP2F1 CBR3 AOC3 ARNT2 NQO2 AOC1 AOC2 GSS FMO1 FMO2 CYP2W1 CALM1 GSTA5 GSTA4 AADAC GSTA3 PNMT DMGDH GCHFR GSTA2 MTRR GSTA1 GCH1 PTS GGT3P GLDC GLS UGT1A10 TPMT GCSH IL4I1 AHR HYKK CNDP2 AKR7A2 TDO2 CKMT1B ABHD10 HPGDS GLUL AKR7A3 SEPHS2 UGT2B10 GAMT UGT2B11 PDHX SDS UGT2B15 TSTD1 AIP SECISBP2 UGT2B17 SLC6A12 ALDH3A1 SULT6B1 SLC6A11 GSTT2 HOGA1 GSTT1 ASRGL1 GLYAT GCAT MTAP CYP4F22 LARS1 CYP2C19 CYP2C18 ETHE1 IDO2 CYP19A1 CYP11A1 ALDH7A1 IDO1 ESD GCDH UGT3A2 LIPT1 UGT3A1 TPH2 CYP2J2 SLC45A2 GGT7 TPH1 GGT6 SHMT1 EPHX1 SDSL CYP4F11 LIAS CYP4F12 OAZ1 GGCT OAZ2 GCLC NAT1 SLC5A5 NAT2 ACMSD OAZ3 CYP11B2 AFMID TBXAS1 GCLM NAALAD2 PODXL2 ASL CYP4A22 HAO1 RIMKLA ACSM2A OPLAH RIMKLB PYCR1 ALDH2 PYCR2 CYP4V2 UGT2A3 PYCR3 UGT2A2 TYR UGT2A1 ACADSB AIMP1 SULT4A1 UGT1A1 GLUD1 AIMP2 CYP4A11 HAL CYP3A43 SLC23A2 ALDH6A1 ARNT SLC23A1 ABHD14B GLUD2 BHMT CYP2A7 NADSYN1 CYP2A6 PNPO SLC6A7 ALDH1A1 SLC19A3 SLC6A8 NADK UGT2B4 EPRS1 UGT2B7 TH SLC19A2 ADI1 COQ9 ACSS2 UGT2B28 PAH COQ7 KYAT3 CYP3A5 COQ6 BPHL COQ5 OGDH KYAT1 CYP3A7 COQ3 HIBADH UGP2 CTRC MOCS2 SLC44A1 MAT2A MOCS3 GPT ALDH1B1 CSAD UGT1A5 QPRT UGT1A4 GPHN ADO THTPA AUH BPNT2 NADK2 QARS1 BPNT1 NMRK2 UGT1A3 DLAT ENOPH1 NMRK1 UGT1A9 CD38 AASS ACSS1 UGT1A8 ACAD8 AOX1 UGT1A7 ARG2 SLC25A19 UGT1A6 PDSS2 ARG1 BHMT2 PDSS1 CYB5B SLC7A5 CYP4B1 CYB5A TPK1 AKR7L IVD EEF1E1 MOCOS DLD NMNAT3 OCA2 NMNAT2 ECHS1 KCNG2 NMNAT1 OAT AHCY HSD17B14 KARS1 AKR1B1 HDC HSD17B11 HSD17B1 HAAO ODC1 HSD17B2 TSPO DLST PAPSS1 STARD3 DUOX1 STARD4 RIDA SRD5A2 CARNS1 STARD3NL CKB STARD6 DUOX2 SRD5A1 STAR NQO1 CKM AKR1B15 AADAT CBSL SQOR BBOX1 FAH AGMAT GNMT ALDH4A1 GATM NDUFAB1 OTC KCNC2 FOLH1B HNMT SAT1 TXN2 IYD SLC25A44 RARS1 HGD DIO1 DIO2 PIPOX DIO3 MAT1A KMO FOLH1 SMS NNMT ASMT MRI1 ACAT1 TPO AANAT AMDHD1 PRODH MPST EEFSEC PDHA2 KCNB1 PDHA1 GOT1 AGXT2 GOT2 ASNS AZIN2 NMRAL1 AZIN1 QDPR KCNS3 SEPSECS GRHPR DAO CPS1 PXMP2 SLC25A2 TAT AMD1 GADL1 APIP MTR DBH FTCD DHTKD1 KYNU DBT HIBCH PSTK BCKDHA BCKDHB XYLB MARS1 PHKA1 AMT PHKA2 PRODH2 DARS1 ABO PYGM INMT SLC25A15 FUT1 PHKB SARS1 TST CRYL1 DCT SORD CHDH LALBA PHKG1 ASPG PHKG2 SLC25A10 SLC25A12 CCNC MARCKS BCAT1 NAT8L AGXT ASPA SLC25A13 BCAT2 ALDH9A1 PAOX DDC CARNMT1 GLS2 TYRP1 SLC3A2 PPM1K PDHB HSD17B10 DDO SRM CKMT2 CBS TDH SLC25A21 PCBD1 IARS1 CRYM SLC36A4 TXNRD1 SUOX ASS1 BCKDK GSTZ1 TMLHE UROC1 CTH SARDH NAGS SCLY AGK CDO1 CDK8 SIN3A ITPK1 ALDOB HMGCL ACSS3 BDH2 BDH1 OXCT1 OXCT2 HMGCS2 HMGCLL1 AACS ALOX5 PTGS2 PLA2G15 PLA2G4F PLA2G4D PLA2G4E PLA2G4B PLA2G4C PLBD1 GPCPD1 PCK1 G6PC1 CUBN AMN APOA2 APOA1 APOA4 APOA5 ANGPTL4 CES3 SAR1B LPL APOE LDLR GPIHBP1 ABCA1 MBTPS1 APOC3 NR1H3 APOC2 ALB MBTPS2 PNPLA2 NUDT11 NUDT10 PPIP5K1 PPIP5K2 IP6K3 NUDT3 NUDT4 GPX2 GPX1 GPX4 ALOX15 ALOX12 ALOX12B ALOXE3 ST3GAL4 ST3GAL1 ST3GAL2 PPARGC1B SLC35B3 SLC35B2 SLC27A1 SLC35D1 SLC35D2 SLCO1B1 MED16 MED15 MED17 MED12 SLCO1B3 MED14 MED13 MED10 SLCO1A2 MED27 MED26 MED23 MED25 MED24 MED20 PTPN13 FMO3 PLA2G6 GNS PIP5K1C MED30 MED31 ARF3 ARF1 VAMP2 RAB4A RXRB SYNJ2 SYNJ1 PIK3C2A RRM2 MED8 MED4 SEC23A MED6 MED7 LRP2 SEC24B SEC24A RAB14 SEC24D SEC24C PEX11A FHL2 ANKRD1 TNFRSF21 G0S2 GRHL1 MSMO1 NSDHL PLPP6 INSIG2 INSIG1 IDI2 ACAT2 EBP SCAP DHCR24 ARV1 HSD17B7 GC SEC13 ESRRA INPP5B PLCZ1 PLCE1 ITPKB ITPKC ITPKA PLCH1 PLCH2 PLCD3 PLCD4 PLCD1 MT-ND6 MT-ND4 NDUFA13 MT-ND5 NDUFA11 NDUFA12 NDUFA10 MT-ND2 MT-ND3 MT-ND1 SDHC SDHD SDHA SDHB UQCRC1 SUCLG2 SUCLG1 UQCRC2 TMEM126B NDUFB10 UQCRB NDUFB11 UQCRH NDUFV3 NDUFV2 NDUFV1 TRAP1 COA1 NDUFAF6 NDUFAF7 UQCRQ NDUFAF4 SBF1 NDUFAF5 SBF2 NDUFAF2 NDUFAF3 NDUFAF1 MT-CYB ETFA TMEM186 NNT IDH3B UQCRFS1 ME3 ME2 IDH3A ACAD9 NDUFC1 COQ10B COQ10A NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 NDUFB9 FH NDUFB7 NDUFB6 NDUFB5 NDUFB4 NDUFB3 ETFDH NDUFB2 NDUFB1 UQCR11 UQCR10 NDUFA9 NDUFA8 NDUFA7 TIMMDC1 NDUFA6 FAHD1 NUBPL NDUFA3 NDUFA2 NDUFA1 SUCLA2 DNM2 BLVRB BLVRA FAR1 FAR2 UROD MINPP1 UROS ALAS2 COX15 COX10 AGPAT3 SYT5 INS CA3 CA7 LGMN CA6 PPOX HMBS ISCA2 ISCA1 ISYNA1 LYRM4 SLC25A28 SLC25A37 INPP1 CPOX GLRX5 IMPA1 IMPA2 MIOX HPGD LTA4H FECH INPP5A CA12 CA14 CA13 CA5B CA5A SLC9A1 GPS2 NCOR2 NCOR1 HS3ST3A1 HS6ST1 HS6ST2 HS2ST1 HS6ST3 NDST2 NDST1 NDST4 NDST3 HS3ST3B1 GLCE HS3ST5 HS3ST6 HS3ST4 HS3ST1 HS3ST2 CD36 AKR1D1 HSD17B4 CYP46A1 ABCB11 CYP7A1 CA9 OSBP OSBPL9 ABCC3 HSD3B7 ACOT8 OSBPL7 OSBPL6 PTGIS STARD5 SLC10A1 AKR1C1 OSBPL3 SLC10A2 OSBPL2 ADHFE1 AKR1C3 NR1H4 D2HGDH L2HGDH AKR1C2 AKR1C4 BAAT CYP7B1 CYP8B1 CYP27A1 CYP39A1 CH25H AMACR ACOX2 FABP6 OSBPL1A SLC27A2 SLC27A5 TK1 TYMS SLC5A8 PLCB3 PLCB1 PLCB2 SAMHD1 CDA TCN1 PYGB LPCAT1 PYGL PGAM1 ASAH1 AGL ACLY SNAP25 ALAD GM2A PGM1 NDUFC2 PFKL VAPA CPNE1 CPNE3 ARSA ARSB BST1 GLIPR1 MANBA VKORC1L1 GAA UBIAD1 LRP1 NME2 RETSAT PLB1 TTR APOM RDH11 TTPA LRAT ALDOC BCO2 BCO1 VKORC1 ALDOA RBP4 CLPS AKR1B10 RBP2 RBP1 LRP10 ORMDL3 PNLIP LRP12 N6AMT1 PTGES2 TRMT112 NUP107 NUP188 NUP210 NUP93 POM121 NUP205 ALDH3B1 ABCB4 AAAS MAN2B1 DEGS1 NUP160 POM121C NUP85 TPR NUP88 GCKR NUP155 HK3 NAPRT NUP153 PDXK ABCD4 AGPAT2 SLC2A1 SLC2A2 HK1 GLA NUP62 ABCD1 NDC1 ABCC2 NUP133 ABCC8 HYAL1 DSE HYAL3 NUP50 DSEL NUP54 UST NUP42 NUP43 RAE1 RANBP2 SLC16A1 KCNJ11 GCK NUP35 NUP37 CACNA2D2 NDUFS3 SHMT2 PLD1 INPPL1 NDUFA5 VAPB MTMR4 HSP90AB1 PTGES3 HILPDA CIDEA FITM1 FITM2 HSD17B13 CIDEC GK3P MOGAT3 MOGAT2 MOGAT1 ABHD5 FABP12 GK2 PPP1CC LIPE AGMO GPAT2 DGAT2 GK DGAT1 FABP9 PPP1CA FABP1 FABP2 FABP3 FABP4 GPAM FABP5 GPD2 FABP7 PNPLA4 PNPLA5 PLIN1 LPIN1 LPIN2 LPIN3 MGLL PIK3CA PLCG1 MVD ST6GALNAC6 NEU2 NEU3 NEU1 ST3GAL6 CTSA SRD5A3 GLB1 GMPR2 ADK GMPR AMPD1 AMPD2 AMPD3 DCK APRT ADAL DGUOK PNP HPRT1 ADA PNPLA7 GDE1 GDPD1 GDPD3 PNPLA6 ENPP6 GDPD5 PECR SCP2 NUDT19 PHYH GNPAT ACOT2 ATP5MC1 HACL1 TPST2 CYC1 TPST1 HAO2 EPHX2 CS COQ2 ACO2 HSCB CROT STX1A TAZ CYP11B1 TRIB3 CHAC1 SLC25A17 AGPS ACOX3 FXN NDUFB8 HMMR ATP5F1A ATP5F1B IDH3G NUDT7 CRAT RTEL1 CIAO3 NUBP1 NUBP2 CIAO1 NDOR1 MMS19 CIAPIN1 CIAO2B INPP5E NAMPT CLOCK NPAS2 ARNTL PPARGC1A NR1D1 GDA DPYS NT5C2 NUDT5 DNPH1 TYMP TIAM2 NT5C UPP2 NT5M NUDT16 UPP1 NUDT15 ENTPD2 ENTPD3 ENTPD4 ENTPD6 ENTPD7 ENTPD8 UPB1 NT5C1A NT5C1B DPYD ADPRM ITPA MED19 MED18 MED11 SMPD3 MED29 SMPD2 MED28 MED22 MED21 MED13L NCOA3 MED9 CDK19 PTGDS PIP4K2A SCD5 PIP4K2B THRAP3 FAM120B PIP4K2C CHKB PCYT2 CHKA SELENOI PISD ETNPPL PHOSPHO1 ETNK2 BRIP1 ETNK1 CEPT1 ALPI PIP4P1 FUT10 FUT11 B3GALT4 B3GALT5 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 FUT9 B3GALT2 B3GALT1 B4GALNT2 PIP5K1A PIP5K1B MT-CO1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 TXN SURF1 GPI COX7B COX7C COX8A PPA1 COX5B COX5A COX6C LRPPRC TACO1 COX6A1 G6PD COX6B1 COX19 COX16 COX18 PIK3R6 PIK3CG PIK3R5 COX11 COX14 PI4K2B MTMR2 SACM1L PI4KA CYCS COX20 COX4I1 PTEN RRM2B NDUFA4 AHCYL1 ENTPD1 ENTPD5 PLCG2 HMOX1 ELOVL1 FADS2 ELOVL5 ACSL1 ELOVL2 ELOVL3 FADS1 B4GAT1 GNAI1 GNAI2 HSP90AA1 NT5E PPP1CB G6PC3 GCG PPP2R1A PRKACA GGT1 BTD DPEP2 KHK DPEP1 DPEP3 CYP17A1 GALK1 GALT UBA52 GALE TCN2 GGT5 UBB GLP1R PRKAR2B CD320 UBC GBE1 RPS27A PIAS4 UBE2I VDR NR1H2 RORA RXRA SUMO2 PPARG PPARA ERCC2 EPM2A PRPS2 PRPS1 RPEL1 RPE TALDO1 PGD MMAB DERA RPIA SHPK PGM2 PGLS PPP1R3C TKT PSMD8 MMADHC PRPS1L1 PSMD9 RBKS PSMD6 PSMD7 NAGLU PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LMBRD1 PSMA2 PSME3 NHLRC1 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 GYG2 PSMC3 PSMC4 PSMC1 PSMC2 RAP1A SLC37A4 RAPGEF3 MMACHC RAPGEF4 CBLIF GYS2 DCXR HSD3B2 HSD3B1 SLC25A27 UCP3 UCP2 UCP1 SLC25A14 RAN ACSM1 ACSM2B ABCB1 ABCB7 HMOX2 LHB ACADVL FAAH ACAA2 ACSM3 ECI1 ACSM6 ACAD11 HADH ACAD10 ACOT9 MECR ACOT7 ACOT11 ACSL6 ACOT12 ACSL5 ACOT13 ACSL3 CGA ACOT1 SLC27A3 PTGES HACD1 HACD3 HACD2 HACD4 THEM5 HTD2 MORC2 DECR1 ACBD7 ACBD6 ACBD4 TECRL SLC16A8 ACSF3 MCAT ALOX15B ACSF2 PRXL2B PPT1 SLC16A3 PPT2 ACOT7L SLC25A1 TECR PCTP DBI ACOXL MCEE ACADM ACADS CBR1 SLC26A1 ELOVL4 FAAH2 ELOVL7 PTGR1 PTGR2 FFAR1 ACSBG1 ACSBG2 PON3 PON2 PON1 HSD17B3 HSD17B12 LTC4S HSD17B8 AWAT1 CBR4 OLAH ALOX5AP NAXE RNLS SLC22A13 NAXD NUDT12 HSD11B1 HSD11B2 SERPINA6 ACHE BCHE SLC46A1 AGT VDAC1 CHRM3 CYSLTR2 SLC44A5 SLC44A3 SLC44A4 SLC44A2 PSAP ABCG2 TSHB ADRA2C ADRA2A SLC2A3 CA1 CA2 TKFC CA4 NOSIP ABCC1 ABCC5 CYGB POMC PRSS1 HADHB HADHA ACADL BSG PHYKPL CTRB2 CTRB1 HSPG2 BCAN POLD1 MLX AGPAT1 DCN TSPOAP1 CD44 ADPGK ENO2 ENO3 HK2 ACAN TPI1 PGAM2 BPGM PGM2L1 PGP GAPDH PFKFB2 PFKFB1 PFKFB4 PFKFB3 PGK2 GNPDA1 GNPDA2 PFKM PFKP VAC14 MTMR10 MTMR12 MTM1 INPP4A FIG4 INPP4B PIKFYVE INPP5F PI4K2A PRSS3 PIK3R4 PIK3CB MTMR3 THEM4 MTMR14 PIK3C3 IPPK IPMK IP6K1 IP6K2 PDZD11 PLA2G2A STXBP1 PRKAB2 PRKAA2 PLIN3 PRKAG2 PLIN2 WASL PIK3R1 IQGAP1 CHAT CACNA1A CACNA1E PARP10 PARP6 PARP4 PARP16 PARP9 PARP14 PARP8 AKT1 NUP214 MAT2B PRKCA MAPKAPK2 IDH1 IDI1 MVK ACACB TM7SF2 PMVK SC5D FDFT1 FDPS NFYA HMGCS1 GGPS1 NFYB NFYC CYP51A1 ELOVL6 PRKACG LSS PRKACB SREBF2 SQLE SCD SP1 MTF1 ADCY9 DHCR7 PRKAR1B PRKAR1A PRKAR2A NOSTRIN AGPAT5 PLA2G1B PLA2G5 GNAS LCLAT1 AGPAT4 GPAT4 LIPI EHHADH DECR2 LIPH ACP6 ACOT6 GPAT3 ACAA1 PLA2G2F ACOT4 PLA2G2D CDS1 PITPNM1 PLA2G12A PITPNM3 PLA2G2E PITPNM2 ADCY4 MIGA2 MIGA1 CDIPT ADCY3 DDHD2 ADCY2 DDHD1 ADCY1 LPCAT4 ADCY8 GPD1 ADCY7 PLA2G10 GPD1L ADCY6 PLA2R1 ADCY5 GLTP CERK GBA3 CSGALNACT1 GBA2 CHST7 SPTLC1 SMPD4 CHPF STS CHPF2 NCAN SPTLC2 CSGALNACT2 SPTLC3 SMPD1 BGN ENPP7 VCAN CERS3 CHSY1 CERS4 CHST11 CERS5 CHST12 IMPDH1 CERS6 CHST15 IMPDH2 SPHK2 CSPG5 CSPG4 SPNS2 CHSY3 SUMF2 SUMF1 CHST13 CHST3 PRKD3 CPTP PRKD2 PRKD1 PLPP3 PLPP2 CERS1 PLPP1 CSNK1G2 CERS2 ASAH2 SAMD8 SGMS1 PPM1L SGMS2 UGCG UGT8 ALDH3B2 SGPL1 ARSL ORMDL2 ARSJ ARSK ARSH ARSI SPTSSB B4GALNT1 ARSF SPTSSA ARSG KDSR ARSD B3GALNT1 ORMDL1 SGPP2 SGPP1 GALC ACER2 ACER1 FA2H ACER3 ESYT3 ESYT2 DEGS2 PIK3R3 PLD2 LYPLA1 SPR DDAH1 DDAH2 ZDHHC21 MTMR1 DEFECTIVE SLC1A3 CAUSES EPISODIC ATAXIA 6 (EA6)%REACTOME DATABASE ID RELEASE 76%5619062 Defective SLC1A3 causes episodic ataxia 6 (EA6) SLC1A3 CONSTITUTIVE SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 76%2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B MIB2 MIB1 HEYL EP300 PSEN2 CDK8 APH1A APH1B KAT2B KAT2A HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 JAG1 UBA52 CUL1 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 PTEN REGULATION%REACTOME%R-HSA-6807070.2 PTEN Regulation HDAC3 CBX8 CBX6 CBX4 CBX2 BMI1 NR2E1 CSNK2A1 CSNK2A2 MAPK1 TRIM27 CSNK2B MAPK3 KDM1A RNF2 HDAC5 HDAC7 PHC2 PHC1 RING1 UBA52 EZH2 PHC3 RCOR1 EED AKT1 SNAI1 PML SNAI2 MECOM UBB ATN1 MAF1 SUZ12 UBC JUN RPS27A TNRC6C MOV10 TNRC6A TNRC6B ATF2 AKT3 TP53 PPARG AGO3 AGO4 AGO1 AGO2 CHD4 CHD3 PREX2 USP13 WWP2 RNF146 NEDD4 MKRN1 STUB1 FRK OTUD3 PSMD8 PSMD9 PSMD6 REST PSMD7 HDAC2 PSMD4 HDAC1 PSMD5 PTEN PSMD2 PSMD3 MTA1 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 PSMA4 RBBP7 PSMA1 MTA2 PSMA2 PSME3 MTA3 PSME4 PSME1 PSME2 MBD3 PSMD10 PSMB11 PSMD12 PSMD11 RPTOR PSMD14 XIAP PSMD13 AKT2 MLST8 PSMA7 PSMB10 SLC38A9 PSMA8 GATAD2B PSMB6 GATAD2A PSMB7 EGR1 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 MTOR PSMF1 RRAGA PSMB8 RRAGC PSMB9 SEM1 RHEB RRAGB PSMC5 PSMC6 SALL4 USP7 RRAGD PSMC3 PSMC4 LAMTOR2 PSMC1 LAMTOR1 PSMC2 LAMTOR4 LAMTOR3 LAMTOR5 TNKS2 TNKS APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 76%111465 Apoptotic cleavage of cellular proteins CLSPN CASP6 BCAP31 TJP1 CTNNB1 CASP8 ROCK1 ADD1 TJP2 BIRC2 CASP3 VIM DSP PRKCD PTK2 APC LMNB1 CDH1 CASP7 GSN OCLN DBNL GAS2 DSG1 MAPT SATB1 FNTA PLEC PKP1 BMX STK24 STK26 PRKCQ DSG2 DSG3 ACIN1 SPTAN1 LACTOSE SYNTHESIS%REACTOME%R-HSA-5653890.1 Lactose synthesis LALBA B4GALT1 SLC2A1 GLI PROTEINS BIND PROMOTERS OF HH RESPONSIVE GENES TO PROMOTE TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%5635851 GLI proteins bind promoters of Hh responsive genes to promote transcription GLI1 GLI3 GLI2 TRANSPORT OF CONNEXONS TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 76%190872 Transport of connexons to the plasma membrane GJB2 GJA1 DEFECTIVE RHAG CAUSES REGULATOR TYPE RH-NULL HEMOLYTIC ANEMIA (RHN)%REACTOME%R-HSA-5619042.1 Defective RHAG causes regulator type Rh-null hemolytic anemia (RHN) RHAG BRANCHED-CHAIN AMINO ACID CATABOLISM%REACTOME DATABASE ID RELEASE 76%70895 Branched-chain amino acid catabolism HIBADH PPM1K ACAT1 DBT HSD17B10 HIBCH BCKDHA BCKDHB AUH ACAD8 ACADSB IVD BCKDK DLD ECHS1 BCAT1 SLC25A44 ALDH6A1 BCAT2 MCCC2 MCCC1 SIGNALING BY NOTCH1 IN CANCER%REACTOME DATABASE ID RELEASE 76%2644603 Signaling by NOTCH1 in Cancer HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B MIB2 MIB1 HEYL EP300 PSEN2 CDK8 APH1A APH1B KAT2B KAT2A HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 JAG1 UBA52 CUL1 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 NUCLEOBASE BIOSYNTHESIS%REACTOME%R-HSA-8956320.1 Nucleobase biosynthesis IMPDH1 LHPP IMPDH2 PFAS PAICS ATIC DHODH PPAT ADSS1 ADSL ADSS2 CAD UMPS GART GMPS RELEASE OF APOPTOTIC FACTORS FROM THE MITOCHONDRIA%REACTOME DATABASE ID RELEASE 76%111457 Release of apoptotic factors from the mitochondria GSDMD BAK1 BAX DIABLO GSDME CYCS APOPTOTIC EXECUTION PHASE%REACTOME DATABASE ID RELEASE 76%75153 Apoptotic execution phase BCAP31 CTNNB1 CASP8 TJP2 HMGB1 CASP3 KPNA1 KPNB1 GSN DSG2 SPTAN1 CLSPN CASP6 TJP1 ROCK1 ADD1 BIRC2 VIM DSP PRKCD PTK2 APC H1-1 PAK2 H1-0 H1-3 LMNB1 H1-2 CDH1 H1-5 H1-4 CASP7 OCLN DFFB DFFA DBNL GAS2 DSG1 MAPT SATB1 FNTA PLEC PKP1 BMX STK24 STK26 HMGB2 PRKCQ DNM1L DSG3 ACIN1 PI3K EVENTS IN ERBB2 SIGNALING%REACTOME%R-HSA-1963642.3 PI3K events in ERBB2 signaling NRG1 NRG2 NRG3 NRG4 ERBB2 GAB1 PIK3CA EGF PIK3R1 HBEGF EGFR EREG BTC HIV INFECTION%REACTOME DATABASE ID RELEASE 76%162906 HIV Infection AP1M2 AP1M1 FYN ATP6V1H HCK KPNA1 KPNB1 AP1G1 VPS37C VPS37D VPS37A VPS37B BTRC SKP1 VPS4B VPS4A UBA52 NCBP1 NCBP2 UBB UBC RPS27A LIG1 RAC1 AP1B1 LIG4 CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA DOCK2 NELFB ELOB ELOC NELFCD NELFA ELOA3BP nef B2M NELFE HLA-A SUPT16H ELOA3P CD8B GTF2A1 tat LCK GTF2A2 PACS1 GTF2B ELOA2 CD28 TAF9 SSRP1 CDK9 TAF1L CCNH GTF2E1 RNMT GTF2E2 TAF7L POLR2A TAF9B POLR2B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 TAF4B POLR2I POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 RNGTT TAF3 GTF2H1 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 SEC13 AP2A1 AP2A2 NUP107 NUP188 FURIN AP2M1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 BANF1 PSMD3 NUP210 PSMD1 PSMA5 NUP93 PSMA6 PPIA PSMA3 POM121 PSMA4 PSIP1 NUP205 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 XRCC6 PSMD10 AAAS PSMB11 XRCC5 PSMD12 AP2S1 PSMD11 NUP160 POM121C PSMD14 NUP85 PSMD13 TPR NUP88 PSMA7 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 PSMB4 NUP153 PSMB5 PSMB2 AP2B1 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CHMP4C PSMC4 CHMP4B CUL5 PSMC1 PSMC2 NMT1 CHMP4A NUP62 NDC1 TSG101 NUP133 RANBP1 TCEA1 NUP50 FEN1 NUP54 NUP42 rev VTA1 NUP43 gag-pol RAE1 vif RANBP2 NMT2 vpr vpu RAN NUP35 CHMP2B NUP37 CHMP2A NEDD4L env CD4 CHMP3 CHMP6 CHMP7 CHMP5 MVB12B MVB12A SLC25A5 XRCC4 SLC25A4 SLC25A6 XPO1 RANGAP1 NUP214 CCNK CCR5 AP1S2 AP1S1 AP1S3 VPS28 RBX1 NPM1 HMGA1 CCNT2 PDCD6IP CXCR4 RCC1 ARF1 ELMO1 UBAP1 gag AMPLIFICATION OF SIGNAL FROM UNATTACHED KINETOCHORES VIA A MAD2 INHIBITORY SIGNAL%REACTOME%R-HSA-141444.2 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal PPP2R1B KIF2C MIS12 PPP2R5E KIF2B NUP43 RANBP2 RPS27 DYNC1LI1 DYNC1LI2 B9D2 PPP2R5B SPC24 CDCA8 PPP2R5A SPC25 ERCC6L PPP2R5D SKA1 CENPE PPP2R5C SKA2 NUP37 ZWILCH KNTC1 NUF2 SGO1 NUDC SGO2 PPP2CA PMF1 PPP2CB INCENP CENPA CENPC BUB1B CENPT BUB3 CENPU SEC13 MAD2L1 PPP2R1A CENPH CENPI TAOK1 CENPK CENPL BUB1 CENPM NUP107 CENPN DYNLL2 CENPO CENPP CENPQ CENPS DYNC1I1 DYNLL1 CKAP5 CLIP1 KIF18A MAD1L1 BIRC5 MAPRE1 NDC80 ITGB3BP NUP160 PAFAH1B1 DYNC1I2 NUP85 SPDL1 XPO1 CENPF RANGAP1 CLASP2 NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 RCC2 NUP133 ZWINT AHCTF1 ZW10 NDEL1 KIF2A E2F-ENABLED INHIBITION OF PRE-REPLICATION COMPLEX FORMATION%REACTOME DATABASE ID RELEASE 76%113507 E2F-enabled inhibition of pre-replication complex formation ORC5 ORC4 ORC6 ORC1 ORC3 CDK1 ORC2 MCM8 CCNB1 RETINOID METABOLISM DISEASE EVENTS%REACTOME%R-HSA-6809583.1 Retinoid metabolism disease events RBP4 AXIN MISSENSE MUTANTS DESTABILIZE THE DESTRUCTION COMPLEX%REACTOME%R-HSA-5467340.1 AXIN missense mutants destabilize the destruction complex PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 SIGNALING BY RETINOIC ACID%REACTOME%R-HSA-5362517.2 Signaling by Retinoic Acid PDHB DLAT ADH4 PDHA2 RXRA PDHX PDHA1 CRABP1 DHRS3 CRABP2 RXRB ALDH1A3 RARA SDR16C5 DHRS9 RXRG ALDH1A2 RDH10 DLD RDH16 RDH5 RDH14 DHRS4 RDH13 ALDH8A1 RARG RARB RDH11 CPT1A CPT1B ADH1C PPARD ADH1A CYP26A1 AKR1C3 CYP26B1 CYP26C1 PDK4 PDK3 PDK2 FABP5 PDK1 ALDH1A1 CONSTITUTIVE SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS%REACTOME%R-HSA-2894862.1 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B MIB2 MIB1 HEYL EP300 PSEN2 CDK8 APH1A APH1B KAT2B KAT2A HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 JAG1 UBA52 CUL1 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-264642.4 Acetylcholine Neurotransmitter Release Cycle CHAT SNAP25 SYT1 UNC13B RAB3A CPLX1 RIMS1 SLC5A7 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 VAMP2 PPFIA2 SLC18A3 DRUG RESISTANCE IN ERBB2 TMD JMD MUTANTS%REACTOME DATABASE ID RELEASE 76%9665737 Drug resistance in ERBB2 TMD JMD mutants HSP90AA1 CDC37 ERBB2 ERBIN LIGAND-RECEPTOR INTERACTIONS%REACTOME DATABASE ID RELEASE 76%5632681 Ligand-receptor interactions CDON SHH HHIP DHH IHH BOC PTCH1 GAS1 DOWNREGULATION OF TGF-BETA RECEPTOR SIGNALING%REACTOME%R-HSA-2173788.1 Downregulation of TGF-beta receptor signaling SMAD7 SMAD3 SMURF2 UBA52 USP15 NEDD4L XPO1 UCHL5 UBB UBC RPS27A MTMR4 PMEPA1 PPP1CC BAMBI PPP1CB STRAP STUB1 PPP1R15A TGFB1 PPP1CA SMURF1 TGFBR1 TGFBR2 SMAD2 DEFECTS IN COBALAMIN (B12) METABOLISM%REACTOME%R-HSA-3296469.1 Defects in cobalamin (B12) metabolism MTRR CD320 ABCD4 MMAA LMBRD1 MMUT MMACHC CBLIF TCN2 MMAB CUBN AMN MTR MMADHC SMAD2 SMAD3:SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%2173796 SMAD2 SMAD3:SMAD4 heterotrimer regulates transcription CCNT1 HDAC1 WWTR1 SMAD7 SMAD4 MEN1 SMAD3 SNW1 RBL1 SP1 E2F4 CDK9 UBA52 E2F5 CCNT2 UBB TFDP1 UBC TFDP2 RPS27A RNF111 TGIF1 CDK8 TGIF2 MYC CCNK CCNC JUNB CDKN2B SMAD2 SERPINE1 ATP1B4 DISEASES OF TELOMERE MAINTENANCE%REACTOME%R-HSA-9673013.1 Diseases of Telomere Maintenance DAXX ATRX HATS ACETYLATE HISTONES%REACTOME%R-HSA-3214847.1 HATs acetylate histones KAT8 CREBBP KAT7 TRRAP SUPT20H ATXN7L3 MEAF6 H2AC17 H2AC12 KAT14 HCFC1 TADA2A ZZZ3 BRPF1 BRPF3 TADA2B H2AC21 SGF29 H2AW ING4 ING3 PAX3 SUPT3H ING5 TAF6L BRD8 ELP1 ELP2 ELP3 ELP4 BRD1 ELP5 ELP6 JADE1 JADE3 JADE2 SUPT7L MORF4L1 KAT6B MORF4L2 HAT1 ENY2 TAF5L MBIP DMAP1 DR1 MRGBP YEATS2 TADA1 H2AC1 VPS72 MSL2 MSL3 MSL1 ATXN7 KANSL1 KANSL2 KANSL3 TADA3 OGT SAP130 H2BC18 RUVBL1 USP22 ACTL6A ATF2 PHF20 MCRS1 YEATS4 CLOCK EP400 TAF9 TAF12 TAF10 H2AC19 ACTB H2AC14 H2BC21 EP300 H2BU1 RUVBL2 H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 KAT2A H2BC15 H2BC11 H3C15 WDR5 RBBP7 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 EPC1 NCOA1 NCOA2 KAT5 KAT6A RNA POLYMERASE III TRANSCRIPTION INITIATION%REACTOME DATABASE ID RELEASE 76%76046 RNA Polymerase III Transcription Initiation POU2F1 CRCP ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP BRF2 GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 BRF1 BDP1 POLR1C POLR1D TAT-MEDIATED HIV ELONGATION ARREST AND RECOVERY%REACTOME DATABASE ID RELEASE 76%167243 Tat-mediated HIV elongation arrest and recovery CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 TCEA1 COBALAMIN (CBL, VITAMIN B12) TRANSPORT AND METABOLISM%REACTOME DATABASE ID RELEASE 76%196741 Cobalamin (Cbl, vitamin B12) transport and metabolism MTRR CTRC CD320 ABCD4 MMAA LMBRD1 MMUT TCN1 CTRB2 CTRB1 MMACHC CBLIF TCN2 MMAB CUBN ABCC1 PRSS3 AMN PRSS1 MTR MMADHC RESPIRATORY ELECTRON TRANSPORT, ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING, AND HEAT PRODUCTION BY UNCOUPLING PROTEINS.%REACTOME%R-HSA-163200.1 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. NDUFB4 SLC25A27 NDUFB3 UCP3 ETFDH UCP2 UCP1 NDUFB2 SLC25A14 NDUFB1 UQCR11 UQCR10 NDUFA9 NDUFA8 NDUFA7 TIMMDC1 NDUFA6 NUBPL NDUFA3 NDUFA2 NDUFA1 ATP5MC1 NDUFS3 CYC1 NDUFA5 PM20D1 NDUFB8 ATP5F1A ATP5F1B NDUFC2 MT-CO1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 SURF1 COX7B COX7C COX8A COX5B COX5A COX6C LRPPRC TACO1 COX6A1 COX6B1 COX19 COX16 COX18 ETFB COX11 COX14 NDUFAB1 CYCS COX20 MT-ND6 COX4I1 MT-ATP6 MT-ND4 NDUFA13 MT-ND5 NDUFA11 NDUFA12 NDUFA10 MT-ND2 MT-ND3 MT-ND1 SDHC ATP5MC2 SDHD ATP5MC3 SDHA SDHB UQCRC1 ATP5MG ATP5MF ATP5ME UQCRC2 DMAC2L TMEM126B ATP5PF NDUFA4 NDUFB10 ATP5PD UQCRB NDUFB11 ATP5PB UQCRH NDUFV3 NDUFV2 NDUFV1 ATP5F1C TRAP1 ATP5F1D COA1 ATP5F1E NDUFAF6 MT-ATP8 NDUFAF7 UQCRQ ATP5PO NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 ECSIT NDUFAF1 MT-CYB ETFA TMEM186 UQCRFS1 ACAD9 NDUFC1 COQ10B COQ10A NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 VPR-MEDIATED NUCLEAR IMPORT OF PICS%REACTOME%R-HSA-180910.2 Vpr-mediated nuclear import of PICs BANF1 NUP42 NUP210 NUP43 rev RAE1 gag-pol vif RANBP2 NUP93 vpr POM121 PSIP1 vpu NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR HMGA1 NUP88 NUP155 KPNA1 NUP214 NUP153 SEC13 gag NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 INFLAMMASOMES%REACTOME%R-HSA-622312.1 Inflammasomes fljB BCL2 prgJ BCL2L1 CASP1 SUGT1 NLRC4 APP NLRP1 NLRP3 AIM2 PANX1 hly RELA PSTPIP1 NFKB2 P2RX7 TXNIP PYCARD NFKB1 MEFV TXN HSP90AB1 fliC HMOX1 DEFECTIVE SLC6A18 MAY CONFER SUSCEPTIBILITY TO IMINOGLYCINURIA AND OR HYPERGLYCINURIA%REACTOME%R-HSA-5659729.1 Defective SLC6A18 may confer susceptibility to iminoglycinuria and or hyperglycinuria SLC6A18 AQUAPORIN-MEDIATED TRANSPORT%REACTOME%R-HSA-445717.2 Aquaporin-mediated transport MIP AQP11 PRKACG PRKACB AVP ADCY9 PRKAR1B PRKAR1A PRKAR2A GNG10 GNAS GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 ADCY4 GNB3 AVPR2 ADCY3 ADCY2 GNB5 ADCY1 ADCY8 ADCY7 GNGT1 ADCY6 ADCY5 GNGT2 PRKACA GNG3 RAB11A GNG2 GNG5 GNG4 GNG7 RAB11FIP2 GNG8 MYO5B PRKAR2B AQP12A AQP8 AQP10 AQP9 AQP6 AQP7 AQP4 AQP5 AQP2 AQP3 AQP1 SYNTHESIS OF KETONE BODIES%REACTOME%R-HSA-77111.5 Synthesis of Ketone Bodies ACAT1 HMGCL ACSS3 BDH2 BDH1 HMGCS2 HMGCLL1 AACS G BETA:GAMMA SIGNALLING THROUGH BTK%REACTOME DATABASE ID RELEASE 76%8964315 G beta:gamma signalling through BTK GNG12 GNG11 GNG13 GNB2 GNB1 GNG3 GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 GNGT1 GNGT2 BTK GNG10 P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-372708.1 p130Cas linkage to MAPK signaling for integrins PTK2 FN1 FGB FGA CRK VWF ITGB3 FGG RAP1B RAP1A TLN1 ITGA2B APBB1IP BCAR1 SRC SIGNALING BY FGFR3 POINT MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%8853338 Signaling by FGFR3 point mutants in cancer HRAS GAB1 FGF1 FGF2 PIK3CA PLCG1 FGF4 SOS1 NRAS FGFR3 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF18 KIT MUTANTS BIND TKIS%REACTOME%R-HSA-9669921.1 KIT mutants bind TKIs KIT DEFECTIVE SLC2A2 CAUSES FANCONI-BICKEL SYNDROME (FBS)%REACTOME DATABASE ID RELEASE 76%5619098 Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) SLC2A2 DEFECTIVE ABCA1 CAUSES TGD%REACTOME DATABASE ID RELEASE 76%5682113 Defective ABCA1 causes TGD APOA1 ABCA1 S PHASE%REACTOME%R-HSA-69242.2 S Phase RFC5 RFC3 RFC4 RFC2 RPA1 RPA2 RPA3 SKP1 CDC25B SMC3 LIN54 RAD21 LIN52 GSK3B STAG1 UBA52 STAG2 LIN37 LIN9 SMC1A CUL1 AKT1 UBB RB1 TFDP1 UBC TFDP2 CCND1 POLE RPS27A CDK4 LIG1 E2F1 RFC1 MYC CDKN1A CDKN1B POLD3 POLD4 AKT3 CCNA2 POLD1 CCNA1 POLD2 CCNE2 CCNE1 POLE4 CDK2 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 CABLES1 RBX1 PCNA WEE1 CCNH MAX E2F5 MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDK7 CDC6 MNAT1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 CDC25A ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 CKS1B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 RBL2 PSMA4 PSMA1 PSMA2 GINS1 PSME3 GINS2 PSME4 CDC45 PSME1 GINS3 PSME2 E2F4 GINS4 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 AKT2 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 ESCO1 CDCA5 PDS5B ESCO2 PDS5A WAPL FEN1 DNA2 SIGNALING BY TYPE 1 INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR (IGF1R)%REACTOME%R-HSA-2404192.2 Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GAB1 PIK3CA FLT3 SOS1 CILP AKT2 IRS4 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 NRAS FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 IGF1 FLT3LG FRS2 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 IGF2 PIK3C3 IGF1R FGFR4 PIK3R2 FGF10 DISEASES OF DNA REPAIR%REACTOME%R-HSA-9675135.4 Diseases of DNA repair NEIL3 MSH3 MSH6 PMS2 MSH2 NEIL1 OGG1 NTHL1 MLH1 BRCA1 BARD1 GAMMA CARBOXYLATION, HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION%REACTOME DATABASE ID RELEASE 76%163841 Gamma carboxylation, hypusine formation and arylsulfatase activation ARSA SUMF2 F2 SUMF1 F10 F8 ARSB F7 FN3KRP PROC F9 ARSL GGCX BGLAP ARSJ ICMT TPST2 PROZ ARSK TPST1 ARSH GAS6 ARSI EIF5A EIF5A2 DHPS ARSF DOHH ARSG ARSD FN3K EEF2 DPH1 FURIN STS DPH2 DPH3 DPH5 PROS1 DNAJC24 DPH6 DPH7 IRE1ALPHA ACTIVATES CHAPERONES%REACTOME DATABASE ID RELEASE 76%381070 IRE1alpha activates chaperones KDELR3 SHC1 GSK3A PPP2R5B CUL7 FKBP14 SULT1A3 SEC31A TLN1 CXXC1 MYDGF EXTL2 EXTL1 TATDN2 HSPA5 DNAJB9 SSR1 EXTL3 TSPYL2 LMNA KLHDC3 ZBTB17 DDX11 SYVN1 WIPI1 PDIA5 YIF1A CTDSP2 DNAJB11 SRPRA SRPRB HDGF TPP1 PLA2G4B SERP1 HYOU1 ARFGAP1 GFPT1 DCTN1 GOSR2 ACADVL ATP6V0D1 PDIA6 ADD1 WFS1 EDEM1 DNAJC3 ERN1 PREB APC C:CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C:CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1%REACTOME%R-HSA-174178.3 APC C:Cdh1 mediated degradation of Cdc20 and other APC C:Cdh1 targeted proteins in late mitosis early G1 SKP2 FZR1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 AURKA PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB RB1 PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PTTG1 AURKB PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 PRE-NOTCH PROCESSING IN GOLGI%REACTOME DATABASE ID RELEASE 76%1912420 Pre-NOTCH Processing in Golgi ATP2A1 ST3GAL4 ST3GAL3 TMED2 SEL1L ST3GAL6 B4GALT1 NOTCH2 LFNG NOTCH3 NOTCH4 FURIN NOTCH1 MFNG RFNG ATP2A3 RAB6A ATP2A2 DEFECTIVE INTRINSIC PATHWAY FOR APOPTOSIS DUE TO P14ARF LOSS OF FUNCTION%REACTOME%R-HSA-9645722.2 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function C1QBP CDKN2A SARS-COV-1 INFECTION%REACTOME DATABASE ID RELEASE 76%9678108 SARS-CoV-1 Infection ACE2 TMPRSS2 ST3GAL3 7a 3a GSK3A SUMO1 CHMP2B CHMP2A ST6GALNAC2 PRKCSH CTSL GANAB S ST3GAL4 MGAT1 ST3GAL1 ST3GAL2 ST6GAL1 MAP1LC3B MOGS M CHMP3 CANX CHMP6 ST6GALNAC3 CHMP7 ST6GALNAC4 8b ZCRB1 DDX5 VHL 9b UVRAG VCP GALNT1 PARP10 PARP6 GSK3B PARP4 PARP16 PARP9 UBA52 PARP14 N PARP8 BECN1 E 1a rep UBB RB1 PIK3R4 UBC RPS27A CHMP4C CHMP4B CHMP4A PIK3C3 UBE2I POTASSIUM TRANSPORT CHANNELS%REACTOME%R-HSA-1296067.2 Potassium transport channels KCNJ16 KCNJ1 KCNJ10 DEFECTIVE RFT1 CAUSES RFT1-CDG (CDG-1N)%REACTOME%R-HSA-4570571.1 Defective RFT1 causes RFT1-CDG (CDG-1n) RFT1 THYROXINE BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%209968 Thyroxine biosynthesis DUOX2 TPO IYD SLC5A5 DIO1 TSHB DIO2 DIO3 CGA DUOX1 ADORA2B MEDIATED ANTI-INFLAMMATORY CYTOKINES PRODUCTION%REACTOME DATABASE ID RELEASE 76%9660821 ADORA2B mediated anti-inflammatory cytokines production GPR15 GPR27 GPR25 RLN2 GPR20 RLN3 ADM PTH1R GPR32 PTH2R HTR4 RXFP1 RAMP2 RXFP2 GNG10 RAMP3 GPR45 PTH HTR6 GNAI3 HTR7 GNG12 PRKX GNG11 GNAI1 GNG13 GNAI2 GNB2 INSL3 PTGDR GNB1 TSHB TAAR8 GNB4 PTGIR GPR150 TAAR9 TAAR6 GNB3 AVPR2 TAAR5 TAAR2 GNB5 SCTR GCG TAAR1 GHRH GNGT1 ADM2 RAMP1 PRKACA GNGT2 ADORA2A LHB ADORA2B ADCYAP1 ADCYAP1R1 IAPP MC2R GNAZ CALCA CALCB CALCRL GNG3 GPR83 GPR84 GNG2 CGA CALCR GNG5 GNG4 GNG7 GNG8 TSHR MC1R POMC IL6 GLP1R PRKAR2B MC4R CREB1 GLP2R GIP CRH GPR39 PTH2 PTHLH FSHB GPBAR1 MC3R ADRB3 VIP PRKACG FSHR PRKACB AVP PTGER4 NPSR1 ADCY9 PRKAR1B PRKAR1A PRKAR2A PTGER2 GNAS NPS ADCY4 ADCY3 ADCY2 ADCY1 GPHA2 ADCY8 ADCY7 ADCY6 ADCY5 P2RY11 MC5R GPHB5 CYSLTR2 VIPR1 VIPR2 LHCGR SCT GPR176 GNAT3 ADRB1 ADRB2 TAAR3P HRH2 GIPR DRD1 CRHR1 CRHR2 DRD5 GHRHR SIGNALING PATHWAYS%REACTOME%R-HSA-162582.11 Signaling Pathways CREBBP FAM169A CSF2 TOR1AIP1 AKAP12 CBFB PRKCB BAIAP2L2 RUNX1 BASP1 SHH POTEE HHAT FARP1 ACTN1 DHH IHH RHOF SENP1 DIAPH1 GSK3A DIAPH2 ADAM12 DUSP16 LAMC3 ATP6V1H MAPK1 TRIM27 ITGA3 MAPK3 LAMA4 TWF1 SFPQ HGS RAB7A CYP26A1 CYP26B1 CYP26C1 MYL6 MYL9 FLRT3 RET FARP2 PLXND1 ITGA2B MAP2K1 MAP2K2 SHC3 NCBP1 PLXNA1 SRGAP3 NCBP2 SRGAP1 RPS6 PTPRA CHD8 ITGB3 CBY1 PIK3CD SOX3 SOX17 ITGAV SOX6 SOX7 ITGA2 SOX4 BCL9L CTNNBIP1 EVL SOX13 PYGO1 MET PYGO2 BCL9 SIRT6 ELF3 MFNG RFNG RPS27 TLN1 PFN1 PFN2 GRB7 MYL12B ARTN H2AX H2AB1 H2AC19 NRP1 CHD4 CHD3 ACTB GFRA1 GFRA3 H2AC14 H2BC21 GFRA2 EP300 GFRA4 H2BU1 H3-3B H3C8 H2AC8 TBP H2AC6 PAK5 H2AC7 TERT H2BC17 RANBP9 H2BC12 NRTN H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 H2BC11 HDAC2 MYH14 HDAC1 MYH11 MYH10 H3C15 MTA1 PSPN RBBP4 H2BS1 GDNF RBBP7 FES CNTN1 MTA2 RND1 MTA3 H2AZ1 H2BC9 MBD3 H2AZ2 H4C9 H2BC8 H2BC5 LAMA1 H2BC3 H2BC1 GATAD2B NCAM1 GATAD2A H2AC20 CLASP2 MAPK12 MAPK13 IKBKB SFRP1 SFRP2 HECW1 CHUK CCDC88C CASP10 WIF1 KLHL12 CASP9 IKBKG SOST DACT1 PPP3CC CXXC4 UACA PDK4 PDK3 PDK2 PDK1 NGFR HDAC3 PRDM4 NGF STMN2 MYLK WDR91 EPSTI1 ANKFY1 STARD8 MRTFA FRS3 RGS9 WDR81 RGS6 DAAM1 RGS7 CDCA8 IQGAP3 SKA1 CSNK2A1 SKA2 RHOT2 STARD13 JUP CSNK2A2 FAM135A CDC42SE2 ARHGAP9 ARHGAP8 CSNK2B OSBPL11 ARHGAP4 LRRC1 ARL2 NUF2 GNG10 NUDC RRAS2 GMIP LRRC41 CIT GNG12 CDC42EP5 GNG11 INCENP GNG13 CDC42EP3 CCT6A GNB2 CDC42EP2 PKN3 GNAQ CENPA GNB1 CENPC GNB4 FGD5 CHN2 GNB3 CHN1 FLNA CENPT CENPU GNB5 KIDINS220 WDR11 TMEM59 CENPH GNGT1 CENPI SHKBP1 TUBA1B TAOK1 GNGT2 CENPK CENPL CENPM SPHK1 GOPC PKN2 FILIP1 CENPN PKN1 CENPO CENPP CENPQ CENPS UHRF1BP1L FAM13B FAM13A MSI2 GNA14 STK10 SLK GNG3 MEN1 SHB GOLGA8R GNA15 RALGAPA1 CDH5 GNG2 FAM91A1 SH2D2A PTK2B TEX2 GNG5 CLIP1 AXL GNG4 PHIP ZDHHC7 CRABP2 GNG7 MAD1L1 GREB1 GNA11 RHOBTB2 GNG8 DDRGK1 NR5A2 NDC80 TFF3 NSFL1C TFF1 ZNF217 NF2 EBAG9 ARHGAP11A ARHGAP11B FOXA1 TAGAP PPID STAT3 CAV2 EFHD2 RGS11 SPDL1 CHD1 PLEKHG4 CXXC5 USF2 PLEKHG1 USF1 PLEKHG6 TNFSF10 RANGAP1 TNFRSF10B NIPSNAP2 TNFRSF10A PPP1R12B SRF CFLAR NSL1 TNFRSF10D FLT1 SH3BP1 CSK FLT4 WHAMM VEGFB KDR PPP1R14A PCDH7 VEGFC VEGFD CDC42BPB PGF CDC42BPA MYO19 VEGFA PRC1 CPNE8 GOLGA3 KNL1 SPATA13 ROPN1 TMEM87A KLK3 DSN1 SCAI RCC2 ZWINT B4GALT1 IGF2BP1 ANLN AHCTF1 FAF2 KIF14 HINT2 SH3PXD2A NDEL1 CCDC115 RHOH RHOD GPC5 RHOJ TAX1BP3 RHOU MIS12 ST3GAL3 TRAK1 TRAK2 PLEKHG4B EMC3 CTNNA1 BCAP31 CAVIN1 DLC1 B9D2 SPC24 TJP2 SPC25 ERCC6L RTKN PRAG1 AGO3 ZWILCH SYDE2 AGO4 ARHGAP44 AGO1 ARHGAP40 AGO2 KNTC1 RALBP1 KCTD3 ARHGAP45 ALDH3A2 SGO1 SGO2 ARHGEF25 ARHGAP19 ARHGAP18 PMF1 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 ARHGAP30 DNMBP RND2 ZAP70 GFOD1 CCDC187 RAP1GDS1 FASN TACC3 MOSPD2 BUB1 KDM4C FMNL3 FMNL1 FMNL2 ACTC1 IRAK4 MYD88 FASLG FAS RASGRP3 PRKAA1 CAB39 CAB39L RPTOR STK11 EEF2K AKT2 MLST8 EIF4EBP1 ICMT SLC38A9 EIF4E ABHD17C EIF4B ZDHHC9 STRADA ABHD17B STRADB ABHD17A FNTB TSC2 TSC1 MTOR FST PPM1A RRAGA RPS6KB1 RRAGC RHEB RRAGB WDR83 AKT1S1 PAQR3 RRAGD RGL3 LAMTOR2 RGL1 LAMTOR1 RGL2 LAMTOR4 PEA15 LAMTOR3 DUSP5 LAMTOR5 DUSP2 DUSP1 FNTA IL17RD RAPGEF2 RASGEF1A ANGPT1 TEK PTPN7 PTPN3 COL4A2 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 COL4A5 COL6A3 ACTA2 COL6A6 MDK COL6A5 FCER2 ITGB1 GNAT1 GAST VCL CYFIP1 NCKAP1 PLCB4 RGSL1 TRIO TFRC PPP1R1B NCF1 PDE3A CCL4L2 NCF2 SNAP23 RGS4 NCF4 RGS5 ARHGAP1 RGS2 RGS3 BRK1 RGS1 ARHGAP39 ARHGAP5 PDE8B ARHGAP6 RGS8 ARHGAP35 PDE8A PCP2 DOCK10 GRK5 PREX1 PDGFB GRK6 SYDE1 CRKL GPSM1 ARHGAP42 GPSM2 BAIAP2L1 PDGFRB OPHN1 STAT1 PDE4B STBD1 PDE4A ARHGDIB GPSM3 RAC3 PDE4D LBR PDE4C CPT1B EMD RGS18 PPARD TMPO RGS17 SWAP70 RGS19 ARAP2 RGS14 ARAP3 RGS13 CYBB RGS16 CYBA RGS21 CD86 OCRL RGS20 VRK2 CD80 RGS22 LEMD3 RGS10 VAV2 RGS12 BCR PDE7B TIAM1 PDE7A RAPGEF1 EPOR CDC42EP1 DSG2 VAMP3 GARRE1 AMIGO2 NOXO1 ARHGAP17 PIK3R2 SLC1A5 ARHGAP15 LMAN1 ARHGAP21 HDAC6 ABR PGRMC2 RACGAP1 DDX5 SLITRK3 NHS SLITRK5 ABL2 NCKAP1L WASF1 SRGAP2 WASF2 YKT6 PAK4 IL32 JAG1 UBE2M CAV1 MCAM MCF2 BAIAP2 ARHGAP26 MPP7 ARHGAP32 DIAPH3 ABI2 TAOK3 ABI1 NOXA1 NOX3 ESYT1 NOX1 FERMT2 CCND3 TFDP1 HNRNPM TFDP2 HNRNPF CCND1 CDK4 E2F1 E2F3 MAML2 MAML1 RBPJ HNRNPH1 MYC RUNX3 MAML3 YAP1 NOTCH1 SRC TCF7 LEF1 FOXO3 BCL2L11 HES1 WWTR1 TCF7L2 SMAD4 TCF7L1 SMAD3 SMURF2 SNW1 CTNNB1 KRAS MAMLD1 GTF2A1 GTF2A2 UBE2D3 TNFAIP3 YBX1 PTBP1 CYLD TAX1BP1 PIN1 C1QBP HNRNPA1 FGB FGA VWF FGG F3 ATF1 NCOA1 MAPKAPK3 MED1 NCOA2 CPT1A TBL1XR1 FOXO6 CARM1 NR4A1 RPS6KB2 TBL1X ATP2A3 ATP2A2 ATP2A1 PPP2R1B PPP2R5E PRKG2 TRPC7 ADH4 TRPC6 TRPC3 PPP2R5B PLA2G4A PPP2R5A PPP2R5D PPP2R5C PDE1B PDE1A ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB PDE11A NOS3 ADH1C PDE2A ADH1A PTPN11 PTPRO PDE10A DNER DLGAP5 WWC1 PTPN6 DTX1 CALM1 DTX2 MAPK8 PTCRA DLK1 DYNLL2 PTPN18 MATK PDHX TPH1 CDC14A ALDH1A1 UGT1A3 DLAT NTF4 DLD BDNF CKB PDHA2 PDHA1 MTR DBT HDAC10 HDAC11 ARAF CCNC DKK1 DKK2 DKK4 CD19 BRAP JAG2 FN1 PDHB FZD8 BRAF STRN HEY1 HEY2 KREMEN1 KREMEN2 DUSP8 DUSP9 PAG1 CNKSR2 APBB1IP CNKSR1 MRAS AMER1 KANK1 NEURL1B SHOC2 SYVN1 MIB2 MIB1 HEYL PEBP1 KDM1A RNF43 DOCK11 HGF PORCN KIF5B KIF5A MARK3 MYB WNT3A ESR2 CDK8 DUSP10 KSR1 KSR2 ESRP1 HDAC5 LRP5 GATA3 HDAC8 HDAC9 KLC1 DLL1 HDAC7 LRP6 KLC4 DLL4 HES5 KLC3 KLC2 TRAT1 NEURL1 PIK3AP1 ABL1 PRKCG WNT5B ROR1 ROR2 PTPRK PRICKLE1 LRIG1 WNT1 SPRY1 CDC14B WNT4 RAG2 FZD1 RAG1 RYK ETV4 MAPK6 KIF18A MAPK4 SEPTIN7 CDK5 AMHR2 ZFYVE16 GDF2 SMAD9 SMAD5 BMPR1B RCOR1 BMPR1A DOCK6 ACVRL1 BMPR2 DOCK5 NOG GREM2 DOCK4 IRS4 DOCK3 DOCK9 DOCK8 DOCK7 DISP2 SCUBE2 CAPZB RAC1 JAK2 HHIP ULK3 DZIP1 EFCAB7 BOC IQCE EVC GAS1 KIF2A SPOPL GAS8 SPOP EVC2 KIF2C KIF2B DOCK2 DOCK1 MFN1 MFN2 SH2B3 SH2B2 CENPE LEP FRAT1 FRAT2 TLE4 TLE3 TLE2 TLE1 TLE5 CLTA AP2A1 PCSK6 AP2A2 PCSK5 PCK1 AP2M1 MYLIP ANGPTL3 ABCG1 CETP AP2S1 APOE ABCA1 APOC4 NR1H3 CHRDL1 AP2B1 APOC2 APOC1 P4HB VGF USP7 FSTL1 FSTL3 LAMB2 NOTUM CDC73 SMAD2 FOXH1 ACVR1B ACVR2B ACVR2A LEO1 DRAP1 ACVR1C CER1 ST3GAL4 APOD RING1 DDX4 TNFAIP1 RND3 FLOT2 MUC13 FAM83B DSP ANKRD26 PLEKHG5 TMOD3 SEMA4F SCRIB PTPN13 CKAP4 SKI KTN1 NISCH CCDC88A VANGL2 UBXN11 CPD KCTD13 DSG1 PKP4 PICALM ITSN1 FNBP1L GJA1 AKT3 FNBP1 DYNC1LI1 DYNC1LI2 SFN PIP5K1C KMT2D FZD4 ARPC1A CLTB AREG EPS15L1 IL2RA HBEGF ARF6 EGFR TRIM33 GGA3 STX5 RHOBTB3 DVL2 SMARCA4 RAB6A RAB4A BMI1 RXRB ARPC4 RXRG ARPC5 ARPC2 ARPC3 ARRB1 ARRB2 IL2 IL3 BMP2 TGIF1 TGIF2 RNF2 ACTR2 ARFGAP3 SPTB JUNB ARFGAP2 PHC2 PTPN2 PHC1 TIAL1 TIA1 RBFOX2 ESRP2 FGFBP1 FGFBP2 FGFBP3 PHC3 RARG ASH2L RSPO3 TCF12 RARB WWOX CDKN2B PLAT EREG BTC THBS4 ZW10 THBS3 PDGFD CFTR SPTBN4 SPTBN5 TGFA SCFD1 SPTBN2 STAM SH3KBP1 TMED2 SEC13 FLRT2 FLRT1 SKIL CTTN RHOQ NEDD8 EPS15 DYNC1I1 CD55 TJP1 EPGN TRIP10 RAB9A RAB9B RBBP5 SH3GL3 SH3GL2 SH3GL1 SOX2 WNT5A SOX9 STAM2 CITED1 SPTA1 GRK3 GRK2 ATP1B4 KCTD6 CBX8 CBX6 POU2F1 CBX4 CBX2 SMAD6 NR2E1 THBS1 YWHAQ YWHAH EPN1 DNM1 DNM2 DNM3 ALS2 MYH9 CSN2 STMN1 ADAP1 MXD4 RALA CBL INS SMC3 EGF RAD21 STAG1 STAG2 CILP WLS SMC1A AMOTL2 AMOTL1 VPS29 FGFRL1 DTX4 DUSP4 VPS35 DUSP3 TMED5 VRK3 SAV1 DUSP6 NPHP4 DUSP7 VPS26A MAPK7 MOB1B MOB1A CAMK2B STK4 CAMK2D STK3 LATS1 CAMK2A GPS2 LATS2 AURKB CAMK2G NCOR2 TNRC6C MOV10 EPO CREB1 NCOR1 CAMK4 TNRC6A TNRC6B ID1 BTK KDM4A KDM4B PPP5C AKR1C3 CDON FABP6 TAS2R60 TAS2R7 TAS2R9 TAS2R40 TAS2R8 TAS2R41 TAS2R20 TAS2R42 TAS2R43 TAS2R45 TAS2R46 GRM1 GRM3 GPRC6A GRM2 GRM5 GRM4 GRM7 GRM6 GRM8 TAS1R2 TAS2R1 TAS1R1 TAS2R3 TAS1R3 TAS2R5 TAS2R4 TAS2R50 GABBR2 CASR GABBR1 TAS2R30 TAS2R31 TAS2R10 EGR1 TAS2R13 TAS2R14 TAS2R16 TAS2R38 TAS2R39 TAS2R19 PDGFRA NFKBIA RELA DOK1 PTK6 ARAP1 TNKS2 TNKS PPP3CA PPP3CB GNAT2 MAP3K7 PRKG1 PLCB3 PLCB1 PLCB2 NLK PPP3R1 WNT11 PDE6B PDE6A FZD3 FZD5 PDE6G FZD6 NFATC1 GNAO1 FYN PAK3 RAB4B GOLGA7 CCNT1 NELFB CDK9 ACTN2 RASGRF2 RASGRF1 GRIN2B PTPRJ GRIN1 GRIN2D DLG1 DLG2 DLG3 LRRC7 DLG4 NEFL RDH11 CHEK1 NUP107 ABCG8 ABCG5 VCP SEL1L AAAS NUP160 NUP85 ADGRE5 ADGRE3 NUP133 KDM3A ARL4C DERL2 EEPD1 GNAL ERLEC1 OS9 NUP43 RANBP2 NUP37 ANKLE2 ARHGDIG ARHGDIA MCF2L VAV3 PLEKHG3 ARHGEF16 RHOG VAV1 NDUFS3 ELMO2 ARHGEF5 ARHGEF26 SHMT2 PLD1 RNF41 IQGAP2 KALRN IL5RA NDUFA5 CSF2RB IL2RG HSPE1 LETM1 CSF2RA VAPB IL5 IL2RB MAP3K11 IL3RA MTMR4 PMEPA1 BAMBI STRAP ANOS1 H3-4 NFKB1 HSP90AB1 STIP1 DNAJB1 PTGES3 FKBP4 FKBP5 TYK2 NOTCH2 LFNG NOTCH3 NOTCH4 ARHGEF28 ARPC1B ACTG1 CFL1 LYN YES1 LIMK2 LIMK1 PTK2 CDC20 PPP1CC PPP1CA GPAM FABP5 FABP7 PLIN1 MGLL SHC1 GAB1 PIK3CA PLCG1 SOS1 CTBP2 CTBP1 ST3GAL6 LRRK2 PELP1 NRG1 NRG2 NRG3 NRG4 ELMO1 CRK KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN HIF1A SOCS3 GPNMB STAP2 PTPN1 SRMS BCAR1 FOXO1 STAT5A STAT5B IRAK1 RIPK2 S100B TRAF6 TAB3 TAB2 TAB1 KPNA2 GNA13 AAMP YY1 KIT MEF2A MEF2C ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 NTRK3 NTF3 PPP1R15A GRB10 TRIB3 CDC25C DHRS4 CENPF PML ARL13B PDE6D ATF2 SERPINE1 NRIP1 MEF2D SPPL2B SPPL2A TNF ARHGEF40 UL36 PRKCI USP4 USP2 OMG CLIP3 TIAM2 MAG OBSCN RBCK1 SQSTM1 NGEF NSMAF BEX3 MAGED1 PSEN2 RTN4 APH1A BAG4 APH1B SHARPIN ECT2 CRMA ARHGEF33 ARHGEF35 ARHGEF37 PBX1 ARHGEF39 ARHGEF38 NET1 SPI-2 OTUD7B ARHGEF10L AATF SMPD3 SMPD2 AKAP13 RACK1 CASP2 PSENEN NAB1 ARHGEF11 NAB2 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 SRY TRAF1 SORCS3 EGR2 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 NCOA3 ARHGEF2 SOS2 BIRC2 ITGB3BP BIRC3 ARHGEF6 LAMA2 RNF31 XIAP FGD1 FGD2 FGD3 FGD4 LINGO1 USP21 BAD OTULIN PHB WNT10B SALL4 AMH KAT5 PIP4K2A PIP4K2B PIP4K2C MAPKAPK5 MAPKAP1 GRAP2 PRR5 HGFAC PDPK1 SGK1 RICTOR CDK5R1 NTRK1 NTRK2 ADCYAP1 ADCYAP1R1 MEMO1 VHL POGLUT1 POFUT1 CRABP1 DHRS3 ALDH1A3 SDR16C5 DHRS9 ALDH1A2 RDH10 EZH2 RDH16 RDH5 RDH14 RDH13 ALDH8A1 EED IER3 PIP5K1A PIP5K1B SNAI1 SNAI2 MECOM PHLPP2 PHLPP1 ATN1 MAF1 SUZ12 JUN LMNB1 BMP10 CCNK PRMT1 FOS FZD10 CRHBP WNT10A FZD9 UCN3 UCN2 WNT9B WNT9A WNT8A STEAP3 WNT8B CCNT2 WNT7B WNT7A WNT6 WNT2 WNT3 PTCH2 UCN WNT2B ADGRE1 ADGRE2 WNT16 PDE1C PIK3R6 PIK3CG PIK3R5 CTNND1 PTEN RBL1 BIRC5 E2F4 BAX CYFIP2 VIPR1 VIPR2 AHCYL1 SCT WIPF1 WIPF2 WIPF3 GPR176 GNAT3 GIPR CRHR1 CRHR2 GHRHR PLCG2 GPR15 FZD7 GPR27 GPR25 GPR20 ADM PTH1R TNS4 TNS3 SYK GPR32 PTH2R RAMP2 RAMP3 GPR45 PTH GNAI3 WAS PRKX GNAI1 GNAI2 HSP90AA1 CDC37 ERBB2 ERBIN YWHAE GPR150 CCP110 PPP1CB SCTR MYO9B GCG PPP2R1A GHRH ADM2 RAMP1 BTRC PRKACA YWHAG SKP1 OFD1 PPP1R12A IAPP GNAZ CALCA CALCB CALCRL CSNK1E GPR83 DYNLL1 GPR84 CKAP5 NCKIPSD CALCR MUC20 MAPRE1 DVL1 UBA52 DVL3 PAFAH1B1 DYNC1I2 CUL1 IL6 UBB GLP1R PRKAR2B UBC RPS27A CLASP1 DYNC1H1 NDE1 PLK1 GLP2R GIP CRH CDK1 PTH2 HDAC4 PTHLH NR1H2 WASF3 NR3C1 ESR1 VIP AR FLT3 RXRA RARA LCK PPARG PGR CD28 CAMKK1 CAMKK2 POLR2A THBS2 POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H LIN7B POLR2I POLR2J POLR2K POLR2L NBEA GTF2F1 PREX2 GTF2F2 USP13 WWP2 RNF146 NEDD4 MKRN1 STUB1 FRK OTUD3 UBE2D1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 ARHGAP10 PSMA3 PSMA4 PSMA1 PSMA2 GALNT3 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 ZRANB1 PSMB5 PSMB2 PSMB3 APC PSMB1 PSMF1 PAK2 PSMB8 PSMB9 PRKCE SEM1 PSMC5 PTPN12 PSMC6 PSMC3 RASGRP2 PSMC4 RASGRP1 CUL5 PSMC1 RAP1B PSMC2 RAP1A RAF1 RAPGEF3 RAPGEF4 TNFRSF1A CASP8 TRADD RIPK1 TRAF2 FADD NPFFR2 APP OXTR NPFFR1 RXFP4 RRH HTR4 NEDD4L GRPR RXFP1 RXFP2 RXFP3 EDNRA HTR6 EDNRB HTR7 C3AR1 HMOX2 OXER1 RRAD PROK2 PROK1 ASCL1 LYL1 PTGDR CMKLR1 JUND EGR3 UTS2R EGR4 TAAR8 TAAR9 FOSL1 TAAR6 ARC NPFF ID2 TAAR5 ID4 TAAR2 FOSB GPR37L1 ID3 TRIB1 PDYN TAAR1 CDK5R2 TRHR UTS2B KEL AGTR1 AGTR2 PTGFR LHB LPAR1 FPR1 LPAR2 LPAR3 FPR3 LPAR4 FPR2 C3 NLN MC2R C5 GALR3 GALR2 GALR1 NPBWR1 PENK NPBWR2 PPY HCRT WWP1 CGA CCR10 NTSR1 NTSR2 CCR1 GPR17 NMB XCR1 PPBP NMBR MC1R LPAR5 LPAR6 NMS GPR183 PNOC NMU GNRH2 GNRH1 GPR18 PTGDR2 QRFP CX3CL1 MLN BRS3 MC4R GPR132 CCKAR OPN1LW CCR9 FFAR4 GNRHR CCR8 FFAR3 CCR7 FFAR2 FFAR1 CCR6 CCR5 CCR4 CCR3 OXGR1 CCR2 GPR39 EDN1 EDN2 ANXA1 GPR37 EDN3 AVPR1B GPR35 FSHB TACR2 GPBAR1 GPR31 PTPRS TACR3 TCIRG1 AVPR1A TACR1 F2 MC3R GAL ADRB3 CCKBR OPN1MW FSHR AVP RGR PTGER4 NPSR1 OPRD1 CCL13 NPB CCL11 PLPPR1 PLPPR2 GRP PTGER1 PLPPR3 PTGER2 PLPPR4 PTAFR PTGER3 PLPPR5 CXCR5 CXCR4 CXCR6 NPS PROKR1 PROKR2 UHMK1 NPW CXCR1 CXCR3 NPY CXCR2 KISS1R RHO CCL19 PRLH CCL17 GPHA2 CCL16 CCL25 P2RY12 IGF1 P2RY13 P2RY10 SHC2 CCL22 RALGDS P2RY11 DNAL4 CCL21 ATP6V1E1 RALB CCL20 RIT1 P2RY14 ATP6V1E2 RIT2 GPR55 ATP6V1G1 IGF2 GPR4 ATP6V1G2 IGF1R AGT ATP6V0E1 GPR143 XK MT-RNR2 MC5R SAA1 F2RL1 CCL28 ATP6V0D1 CCL27 ATP6V0D2 F2RL2 PF4 F2RL3 GPHB5 CHRM2 CHRM3 CHRM1 ATP6V0A2 GPR68 ATP6V0A4 CHRM4 GPR65 NPY2R CHRM5 PMCH CXCL13 ATP6V1C1 CXCL16 CYSLTR1 CYSLTR2 ATP6V0A1 ADORA3 ATP6V1C2 CCRL2 ADORA1 GHSR LHCGR F2R NPY1R MTNR1A LTB4R2 MTNR1B APLNR UTS2 SUCNR1 CCL3L3 C5AR2 C5AR1 ADRB1 ADRB2 NTS MCHR1 MCHR2 KNG1 HCAR2 HCAR3 TAAR3P HRH1 ATP6V0B HCAR1 HRH3 TBXA2R HRH2 PSAP HRH4 TAC3 DRD1 DRD2 TAC1 DRD3 DRD4 DRD5 ATP6V0C OPN4 OPN3 HTR1E HTR1F SOCS6 HTR1D HTR1A HTR1B ATP6V1G3 OPN5 ATP6V0E2 CXCL10 PYY CXCL11 CXCL12 RLN2 RLN3 NMUR2 NMUR1 CXCL6 CXCL9 CXCL8 MLNR HTR2B HTR2C OXT ECE1 ADRA1D CXCL1 HTR2A ECE2 TRH CXCL3 ADRA1B CXCL2 ADRA1A ATP6V1A CXCL5 LTB4R HEBP1 GPER1 BDKRB2 PRLHR BDKRB1 INSL3 QRFPR INSL5 TSHB ATP6V1D PTGIR NPY5R GNRHR2 ATP6V1F AVPR2 OPRM1 SSTR1 SSTR2 ADRA2C SSTR3 ADRA2B SSTR4 ADRA2A ABCD3 SSTR5 CORT ADORA2A ADORA2B XCL2 XCL1 CX3CR1 NPY4R ATP6AP1 OPRL1 P2RY6 CCL7 CNR2 P2RY4 ATP6V1B2 CNR1 ATP6V1B1 CCL5 P2RY2 CCL4 P2RY1 CCL3 S1PR1 CCL2 ADD3 CCL1 S1PR3 S1PR2 S1PR5 S1PR4 OPRK1 CCK HTR5A HCRTR2 STOM TSHR APLN HCRTR1 KISS1 SLC4A7 POMC OPN1SW SST ACKR4 ACKR3 ACKR2 ACKR1 RUVBL1 CDH1 RNF111 PARP1 ADAM10 ADAM17 KLK2 PSEN1 NCSTN COL9A1 COL9A3 COL9A2 LAMC2 LAMC1 PTPRU FER TEC GRAP CASP3 DDX39B CTSD RANBP10 MMP7 MMP2 MMP3 MMP9 INHBB INHBA LAMA5 SOCS1 LAMA3 FURIN PLG JAK1 SPP1 LAMB3 CMA1 LAMB1 BCL2 BCL2L1 MKNK1 SPRY2 STAT6 ZNRF3 RSPO2 RSPO1 LGR6 LGR5 LGR4 KLB RSPO4 IRS1 PDE3B PIK3R4 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 FGF20 GFAP THEM4 FGF23 FGF22 S100A9 INSR FLT3LG S100A8 FRS2 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 GABRB3 GABRB2 TRRAP GABRB1 GABRG3 GABRG2 GABRQ GABRA1 SNX3 RHOT1 RCE1 UCHL5 PRKAB2 PRKAA2 PRKAG1 PLIN3 PRKAG2 PRKAB1 PRKAG3 ZNF512B USP17L2 CLTC WASL PIK3R1 IQGAP1 SH3RF1 KDM1B ARHGAP12 CDC42 PAK1 USP8 NCK2 PAK6 WDR6 CEP97 SPTAN1 GIT1 SPTBN1 FOXO4 NCK1 GIT2 TPM4 DST USP9X SMAD1 TPM3 SMAD7 TXNL1 MYO9A VANGL1 DEPDC1B PEAK1 USP34 DLG5 RHOV ARHGEF7 EPHA2 GSK3B AXIN1 AXIN2 YWHAB HSPB1 USP15 XPO1 AKT1 PRKCD PRKCA YWHAZ MAPKAPK2 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH MAPK14 DGKZ RASGRP4 MAPK11 DGKQ PRKCQ EIF4G1 DAGLB DGKK CDKN1A DGKI CDKN1B DGKH CCNE1 TP53 CDK2 MDM2 IFT172 PRKACG PRKACB DYNC2H1 RPGRIP1L SCD SP1 RBX1 IFT88 ADCY9 PRKAR1B SMO E2F5 PRKAR1A GPR161 RHOC INTU RHOB GNA12 KIF3A TTC21B PLXNB1 PRKAR2A PTCH1 IFT122 FLOT1 FUZ ADCY10 GNAS MKS1 GLI1 GZMB GLI3 GLI2 IFT52 SUFU IFT57 IFT140 KIF7 WDR35 NUMB ADCY4 TULP3 BUB1B ADCY3 ADCY2 BUB3 ADCY1 MAD2L1 NRP2 ADCY8 ADCY7 ADCY6 ADCY5 CSNK1A1 WDR19 JAK3 ITCH IL6R REST MAP2K5 SPINT1 MST1 HPN IL1RL1 MST1R SPINT2 IL33 SPEN RNF20 CCT2 CPSF7 ROCK1 ROCK2 CSNK1G2 CUL3 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 MYO6 PDE5A RBBP6 VIM HNRNPC CCT7 RBMX DBN1 SPRED3 SPRED2 SPRED1 SYNGAP1 HRAS RASA3 RASA4 RASA1 RASA2 RASAL1 RASAL2 RASAL3 NRAS DAB2IP NF1 KBTBD7 RAC2 ARMCX3 CDC42EP4 SPARC TGFB1 PIK3R3 SMURF1 PLD2 ARHGEF18 CGN SAMM50 F11R MTX1 PRKCZ DEF6 LYPLA1 TGFBR1 RHOA TGFBR2 FKBP1A ZDHHC21 PARD6A PARD3 MTMR1 SOWAHC IL-6-TYPE CYTOKINE RECEPTOR LIGAND INTERACTIONS%REACTOME%R-HSA-6788467.3 IL-6-type cytokine receptor ligand interactions LIF IL11 OSMR IL31 IL6ST OSM TYK2 IL11RA CRLF1 CNTFR CNTF JAK2 IL31RA CTF1 CLCF1 JAK1 LIFR G BETA:GAMMA SIGNALLING THROUGH PLC BETA%REACTOME DATABASE ID RELEASE 76%418217 G beta:gamma signalling through PLC beta GNG12 PLCB3 GNG11 PLCB1 GNG13 PLCB2 GNB2 GNB1 GNG3 GNB4 GNG2 GNB3 GNG5 GNG4 GNB5 GNG7 GNG8 GNGT1 GNGT2 GNG10 VITAMINS B6 ACTIVATION TO PYRIDOXAL PHOSPHATE%REACTOME%R-HSA-964975.1 Vitamins B6 activation to pyridoxal phosphate PDXK PNPO AOX1 TRANSLATION INITIATION COMPLEX FORMATION%REACTOME%R-HSA-72649.3 Translation initiation complex formation RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 FAU RPS21 RPS24 RPS23 EIF4H EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 RPS4X RPS15 EIF4A1 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 EIF4E EIF4B RPS8 RPS5 RPS6 RPSA PABPC1 RPS3A RPS27A RPS4Y2 RPS27L RPS4Y1 EIF4G1 RPS15A RPS3 RPS2 NTF3 ACTIVATES NTRK2 (TRKB) SIGNALING%REACTOME DATABASE ID RELEASE 76%9025046 NTF3 activates NTRK2 (TRKB) signaling NTRK2 NTF3 DEFECTIVE F8 ACCELERATES DISSOCIATION OF THE A2 DOMAIN%REACTOME DATABASE ID RELEASE 76%9672387 Defective F8 accelerates dissociation of the A2 domain F8 OLFACTORY SIGNALING PATHWAY%REACTOME%R-HSA-381753.3 Olfactory Signaling Pathway OR11H2 OR11H1 OR2M7 OR11H4 OR2M5 OR2M4 OR2M3 OR4K17 OR1K1 OR2M2 OR4Q3 OR4Q2 OR10AC1 OR1F12 OR2AE1 OR11H6 OR11H7 OR2L8 OR1J4 OR11G2 OR2L5 OR1J2 OR2L3 OR1J1 OR4P4 OR2L2 OR10AD1 OR6T1 OR4K15 OR4K14 OR4K13 OR13J1 OR7A2P OR1I1 OR2K2 OR6S1 OR5M11 OR5M10 OR2I1P OR10D3 OR8B12 OR14K1 OR4N5 OR2J3 OR4N4 OR2J2 OR2J1 OR4N2 OR5P3 OR5P2 OR10C1 OR10J1 OR11L1 OR10J3 OR10J5 OR10J4 OR5W2 OR6Y1 OR52B2 OR52B6 OR9A1P OR1N2 OR1N1 OR5V1 OR6X1 OR52A1 OR52A5 OR10H1 OR10H3 OR10H2 OR10H5 OR10H4 OR1M1 OR4S2 OR4S1 OR2AG1 OR2AG2 OR1F2P OR14A16 OR10G2 OR1L8 OR10G4 OR1L6 OR10G3 OR1L4 OR1L3 OR1L1 OR5T3 OR5T2 OR5T1 OR6V1 OR10G6 OR10G8 OR10G7 OR10G9 OR52W1 OR1S2 OR1S1 OR13D1 OR14C36 OR5AS1 OR4A4P OR2T8 OR2T7 OR2T6 OR2T5 OR2T4 OR2T3 OR2T2 OR13C9 OR2T1 OR13C8 OR4X2 OR4X1 OR2L13 OR9A4 OR51T1 OR9A2 OR13C3 OR13C2 OR13C5 OR13C4 OR5AR1 OR2S2 OR1Q1 GNAL OR51S1 OR4A47 OR5B21 REEP1 OR1P1 REEP5 REEP4 REEP3 REEP2 REEP6 OR8G2P OR13A1 OR7E24 OR7A10 OR14J1 OR13H1 OR56B1 OR2Y1 OR8D4 OR8D2 OR56B4 OR8D1 OR7A17 OR6C70 OR6C76 OR6C75 OR6C74 OR13G1 OR14I1 OR10A7 OR56A5 OR7A5 GNG13 OR10A2 OR56A4 OR52Z1 OR10A4 GNB1 OR56A3 OR10A3 OR10A6 OR56A1 OR10A5 OR6C65 OR8B8 OR2W3 OR2W1 OR8B4 OR8B3 OR6C68 OR13F1 OR8B2 OR12D3 OR12D2 OR5AU1 OR51V1 OR2V2 OR2V1 OR8A1 OR11A1 OR7G2 OR7G1 OR8I2 OR9K2 OR52N1 OR52N5 OR52N4 OR52N2 OR51L1 OR5D18 OR10W1 OR52L2P OR2A42 OR5D16 OR5B3 OR5B2 OR5D14 OR8H3 OR5AL1 OR5D13 OR8H2 OR8H1 OR56B2P OR52M1 OR10V1 OR2AT4 OR4C12 OR6C6 OR4C11 OR6C4 OR5A2 OR8G5 OR6C3 OR4C16 OR5AK2 OR6C2 OR5A1 OR4C15 OR6C1 OR4C13 OR8G1 OR9I1 OR10T2 OR51J1 OR52L1 OR7D4 OR6B3 OR6B2 OR6B1 OR7D2 OR2A25 OR51I2 OR10S1 OR52K2 OR51I1 OR52K1 OR9G9 OR4D11 OR2A12 OR4D10 OR2Z1 OR6A2 OR9G4 OR7C2 OR7C1 OR9G1 OR2A14 OR5G3 OR4E2 OR4E1 OR3A4P OR51Q1 OR4D9 OR5AP2 OR5B12 OR4D6 OR10D4P OR4D5 OR5B17 OR4D2 OR2B8P OR4D1 OR5F1 OR10Z1 OR52R1 OR4C6 OR4C5 OR3A3 OR14A2 OR4C3 OR3A2 OR4A15 OR3A1 OR4A16 OR8K5 OR8K3 OR8K1 OR4C45 OR5AN1 OR4C46 OR4B1 OR8J3 OR6F1 OR8J2 OR8J1 OR51M1 OR10X1 OR4A8 OR4A5 OR7G3 OR5C1 OR1C1 OR5K4 OR5K3 OR5K2 OR51D1 OR5K1 OR6M1 OR2W6P OR2T12 OR2T10 OR2T11 OR5H15 OR5H14 OR52A4P OR2D3 OR2D2 OR1B1 OR52E4 OR5J2 OR52E2 OR52E1 OR2W5P OR52P1P OR5AC2 OR5AC1 OR52E8 OR52E6 OR52E5 OR2C3 OR1A2 OR6K6 OR14L1P OR1A1 OR2C1 OR6K3 OR51B2 OR6K2 OR5I1 OR52D1 OR9Q2 OR9Q1 OR2AK2 OR51B6 OR51B5 OR51B4 OR2B6 OR4F6 OR2B3 OR4F5 OR5H6 OR2B2 OR10K2 OR4F4 OR10K1 OR4F3 OR5H2 OR5H1 OR6J1 OR2AJ1 OR51A4 OR2A7 OR51A2 OR2A5 OR2A4 OR51A7 OR2A2 RTP4 RTP5 RTP2 OR52J3 RTP3 OR51H1 RTP1 OR8U9 OR1G1 OR8U8 OR4M2 OR4M1 OR10R2 OR10AG1 OR6Q1 OR8U3 OR8U1 OR51G2 OR52I2 OR51G1 OR52I1 OR1F1 OR2H2 OR2H1 OR4L1 OR6P1 OR10Q1 OR2AP1 OR2B11 OR51F2 OR51F1 OR5M9 OR2G6 OR52H1 OR5M8 OR1E3 OR1E2 OR4K5 OR2G3 OR1E1 OR2G2 OR4K3 OR4K2 OR5M3 OR4K1 OR5M1 OR10P1 OR8S1 OR2T34 OR2T35 OR2T33 OR5AK3P OR4F21 OR2T27 OR51E1 OR1D5 OR1D4 OR10J6P OR1D2 OR2F2 OR2F1 OR2T29 OR51E2 OR5L2 OR6N2 OR5L1 OR6N1 OR4F17 OR4F15 REGULATION OF FOXO TRANSCRIPTIONAL ACTIVITY BY ACETYLATION%REACTOME DATABASE ID RELEASE 76%9617629 Regulation of FOXO transcriptional activity by acetylation CREBBP FOXO3 KAT2B TXNIP SIRT1 FOXO1 SIRT3 EP300 TXN FOXO4 DEFECTIVE B4GALT1 CAUSES B4GALT1-CDG (CDG-2D)%REACTOME%R-HSA-3656244.2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) B4GALT1 LUM OMD KERA PRELP ACAN OGN FMOD CLASS B 2 (SECRETIN FAMILY RECEPTORS)%REACTOME%R-HSA-373080.2 Class B 2 (Secretin family receptors) FZD8 SHH FZD7 WNT11 DHH IHH FZD3 VIP FZD5 ADM PTH1R FZD6 FZD10 SMO CRHBP PTH2R WNT10A FZD9 UCN3 UCN2 WNT9B WNT9A RAMP2 PTCH1 RAMP3 WNT8A GNG10 WNT8B PTH FZD4 WNT7B WNT7A GNAS WNT6 WNT2 GNG12 WNT3 GNG11 PTCH2 GNG13 UCN WNT2B GNB2 ADGRE1 ADGRE2 GNB1 WNT16 WNT3A GNB4 GNB3 SCTR GNB5 GCG GHRH GNGT1 ADM2 RAMP1 GNGT2 ADCYAP1 ADCYAP1R1 IAPP CALCA CALCB CD55 CALCRL GNG3 WNT1 WNT4 GNG2 FZD1 CALCR GNG5 GNG4 GNG7 GNG8 CYSLTR2 VIPR1 VIPR2 SCT ADGRE5 ADGRE3 GLP1R WNT10B WNT5A GLP2R GIP CRH GIPR CRHR1 PTH2 PTHLH GHRHR SPRY REGULATION OF FGF SIGNALING%REACTOME DATABASE ID RELEASE 76%1295596 Spry regulation of FGF signaling PPP2CA PPP2CB UBB BRAF UBC RPS27A PTPN11 MKNK1 SPRY2 PPP2R1A UBA52 MAPK1 CBL MAPK3 PP2A-MEDIATED DEPHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 76%163767 PP2A-mediated dephosphorylation of key metabolic factors PPP2CA PPP2R1A PPP2R5D PPP2CB PPP2R1B PFKFB1 MLXIPL BINDING AND ENTRY OF HIV VIRION%REACTOME DATABASE ID RELEASE 76%173107 Binding and entry of HIV virion CD4 CXCR4 gag CCR5 rev gag-pol vif env PPIA vpr nef vpu HOMOLOGY DIRECTED REPAIR%REACTOME%R-HSA-5693538.2 Homology Directed Repair RHNO1 BLM BRIP1 ATRIP BRCC3 BARD1 RAD17 RAD9B ATR RAD9A BABAM1 BABAM2 BRCA1 UIMC1 EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 RMI1 TOP3A WRN RBBP8 RPA1 H3-4 RPA2 RAD50 PPP4R2 TIPIN RPA3 TIMELESS PPP4C POLQ RAD1 POLH CLSPN ABL1 HERC2 TP53BP1 UBA52 RNF168 ABRAXAS1 UBB RTEL1 RAD52 UBC POLK POLE RPS27A BRCA2 RAD51AP1 PARP1 XRCC2 RFC1 XRCC3 PARP2 PALB2 RAD51D RAD51 MDC1 LIG3 UBE2V2 SIRT6 PIAS4 RAD51B POLD3 RAD51C UBE2I POLD4 CCNA2 POLD1 CCNA1 POLD2 RNF4 XRCC1 POLE4 ERCC4 ERCC1 CDK2 POLE2 POLE3 ATM SUMO1 SUMO2 PCNA H2AX RNF8 NSD2 MUS81 H2BC21 SLX4 EME1 H2BU1 EME2 GEN1 SLX1B SPIDR H2BC17 H2BC12 H2BC13 CHEK1 H2BC14 H2BC15 H2BC11 H2BS1 H2BC9 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 MRE11 KAT5 NBN HUS1 UBE2N FEN1 DNA2 ASPARAGINE N-LINKED GLYCOSYLATION%REACTOME%R-HSA-446203.4 Asparagine N-linked glycosylation COL7A1 TRAPPC2 ANKRD28 TRAPPC3 SEC16B F8 TRAPPC1 TRAPPC4 SEC16A TRAPPC5 TRAPPC9 CNIH1 SYVN1 CNIH2 CNIH3 MCFD2 PPP6C PPP6R1 PPP6R3 FUCA1 ACTR1A ARFGAP3 SPTB ARFGAP1 CHST10 BET1L CHST8 ARFGAP2 ALG8 SEC22B ALG9 SEC22A ALG6 SEC22C ALG3 RAB1A ALG1 SEC23A LMAN1 RAB1B CSNK1D DYNLL1 UBXN1 YKT6 SEC24B NGLY1 SEC24A RNF139 MLEC UGGT2 UGGT1 UBA52 MARCHF6 EDEM3 PDIA3 EDEM1 AMFR RNF103 DYNC1I2 TRIM13 DCTN2 CALR SEC24D ENGASE DCTN3 SEC24C FOLR1 BET1 KDELR1 GOLGA2 UBB UBC RPS27A CAPZB COG8 COG7 COG6 DYNC1H1 LMAN1L COG5 COG4 COG3 COG2 COG1 RAD23B ANK2 ALG14 ANK3 ALG13 ANK1 ALG12 ALG11 PREB KDELR2 KDELR3 SPTBN4 SPTBN5 LMAN2L TGFA SCFD1 SEC31A RFT1 SPTBN2 CAPZA1 CAPZA2 CTSZ MIA2 MIA3 TMED3 TMED2 TMED7 CTSC SEC13 TMED9 NAPA NAPB STX17 NAPG CD59 DPAGT1 DYNC1I1 CD55 GBF1 VCP SEC23IP ALG10B SAR1B CAPZA3 SEL1L F5 ASGR1 ASGR2 COPG2 COPG1 ACTR10 NSF RNF185 TRAPPC2L TBC1D20 PSMC1 MPDU1 COPB2 COPA TMED10 COPB1 SPTA1 MAN2A2 DERL1 DERL2 RNF5 OS9 UMOD TMEM115 COPE ST6GALNAC2 RPN2 PRKCSH TUSC3 MAN1A2 RPN1 MAN1A1 MAGT1 FUT8 ALG10 GANAB MAN2A1 MGAT5 ST3GAL4 MGAT1 MGAT2 TRAPPC6A ST3GAL1 ST3GAL2 ST6GAL1 EDEM2 MOGS DDOST TRAPPC6B GORASP1 MGAT4C DAD1 MGAT4A MGAT4B CANX STT3A MAN1B1 ST6GALNAC3 ST6GALNAC4 DCTN6 DCTN5 LHB DCTN1 GOSR2 DCTN4 GOSR1 SPTAN1 FUT3 DYNLL2 SPTBN1 INS B4GALNT2 SLC35A1 SLC35C1 MAN1C1 CGA ALG2 MANEA B4GALT1 TFG ST3GAL3 DYNC1LI1 DYNC1LI2 ST6GALNAC1 CMAS MPI GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 GFUS NANS NUDT14 ST6GAL2 ALG5 RENBP DPM1 DPM2 DPM3 MVD ST6GALNAC5 GNE ST6GALNAC6 UAP1 NPL FUOM NEU2 NEU3 NEU4 ARF3 GMDS AMDHD2 B4GALT2 NEU1 ARF4 B4GALT3 ST8SIA4 ARF1 ST3GAL5 SERPINA1 ST8SIA5 ST8SIA6 ST3GAL6 CTSA B4GALT6 PMM1 ST8SIA1 B4GALT4 ST8SIA2 AREG GFPT2 B4GALT5 GFPT1 PMM2 ST8SIA3 SRD5A3 DOLK NUS1 NAGK DHDDS FCSK GLB1 COPZ2 DOLPP1 COPZ1 ARF5 USO1 LMAN2 MGAT3 STX5 TRAPPC10 ARCN1 SLC17A5 GRIA1 WNT5A-DEPENDENT INTERNALIZATION OF FZD4%REACTOME%R-HSA-5099900.1 WNT5A-dependent internalization of FZD4 AP2B1 PRKCA ARRB2 PRKCB PRKCG WNT5A CLTA CLTC AP2A1 CLTB AP2A2 AP2S1 AP2M1 DVL2 FZD4 CRISTAE FORMATION%REACTOME%R-HSA-8949613.2 Cristae formation MICOS13 MICOS10 MT-ATP6 CHCHD6 CHCHD3 ATP5F1A ATP5F1B ATP5MC2 MTX2 ATP5MC3 APOO ATP5MG ATP5MF ATP5ME HSPA9 ATP5MC1 DMAC2L ATP5PF ATP5PD APOOL ATP5PB DNAJC11 IMMT ATP5F1C ATP5F1D ATP5F1E MT-ATP8 TMEM11 ATP5PO SAMM50 MTX1 ACTIVATION OF GABAB RECEPTORS%REACTOME%R-HSA-991365.4 Activation of GABAB receptors GNAL KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 ADCY9 GABBR2 GABBR1 GNG10 GNAI3 GNG12 GNAI1 GNG11 GNAI2 GNG13 GNAT3 GNB2 GNB1 GNB4 ADCY4 GNB3 ADCY3 ADCY2 GNB5 ADCY1 ADCY8 ADCY7 ADCY6 GNGT1 ADCY5 GNGT2 SNRNP ASSEMBLY%REACTOME DATABASE ID RELEASE 76%191859 snRNP Assembly NUP42 NUP43 RAE1 RANBP2 NUP35 SNRPG NUP37 SNRPE SNRPF SNRPB GEMIN2 WDR77 CLNS1A GEMIN4 GEMIN5 PRMT5 GEMIN6 GEMIN7 GEMIN8 DDX20 SMN2 SNUPN SEC13 PHAX NUP107 NUP188 NUP210 NUP93 POM121 NUP205 SNRPD2 AAAS SNRPD1 SNRPD3 NUP160 POM121C NUP85 TPR NUP88 NUP155 NCBP1 NUP214 NUP153 NCBP2 TGS1 NUP62 NDC1 NUP133 NUP50 NUP54 MIDOSTAURIN-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702600 midostaurin-resistant FLT3 mutants FLT3 INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1%REACTOME DATABASE ID RELEASE 76%113501 Inhibition of replication initiation of damaged DNA by RB1 E2F1 PPP2CA PPP2CB RB1 PPP2R1B TFDP1 TFDP2 PRIM2 E2F1 PRIM1 POLA1 POLA2 PPP2R1A PPP2R3B BMAL1:CLOCK,NPAS2 ACTIVATES CIRCADIAN GENE EXPRESSION%REACTOME%R-HSA-1368108.4 BMAL1:CLOCK,NPAS2 activates circadian gene expression CREBBP DBP NAMPT KLF15 CLOCK ARNTL2 NPAS2 ARNTL RXRA AVP NOCT PPARA F7 BHLHE40 NCOA1 MED1 NCOA2 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X SERPINE1 BHLHE41 BLOOD GROUP SYSTEMS BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%9033658 Blood group systems biosynthesis FUT9 B3GALT2 B3GALT1 ST3GAL4 B4GALNT2 ST6GALNAC6 ST3GAL3 ABO FUT1 RHCE RHD ST3GAL6 FUT10 FUT11 B3GALT4 B3GALT5 FUT2 FUT4 FUT3 FUT6 FUT5 FUT7 NONCANONICAL ACTIVATION OF NOTCH3%REACTOME DATABASE ID RELEASE 76%9017802 Noncanonical activation of NOTCH3 PSEN1 PSENEN NCSTN NOTCH3 PSEN2 YBX1 APH1A APH1B SYNTHESIS OF CL%REACTOME%R-HSA-1483076.2 Synthesis of CL CRLS1 RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASES%REACTOME DATABASE ID RELEASE 76%388844 Receptor-type tyrosine-protein phosphatases PTPRS PTPRF PTPRD SLITRK3 LRRC4B SLITRK5 PPFIA1 PPFIA4 PPFIA3 PPFIA2 IL1RAPL2 IL1RAPL1 SLITRK2 SLITRK1 PPFIBP1 SLITRK4 NTRK3 PPFIBP2 SLITRK6 INLB-MEDIATED ENTRY OF LISTERIA MONOCYTOGENES INTO HOST CELL%REACTOME DATABASE ID RELEASE 76%8875360 InlB-mediated entry of Listeria monocytogenes into host cell SH3KBP1 UBB EPS15 SH3GL2 UBC SH3GL1 HGS RPS27A STAM2 UBA52 MET STAM SH3GL3 inlB CBL DEFECTIVE DOLK CAUSES DOLK-CDG (CDG-1M)%REACTOME DATABASE ID RELEASE 76%4755583 Defective DOLK causes DOLK-CDG (CDG-1m) DOLK DEFECTIVE SLC35A1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2F (CDG2F)%REACTOME%R-HSA-5663020.1 Defective SLC35A1 causes congenital disorder of glycosylation 2F (CDG2F) SLC35A1 GLYCOSAMINOGLYCAN METABOLISM%REACTOME%R-HSA-1630316.2 Glycosaminoglycan metabolism HAS2 CHP1 B4GAT1 ST3GAL4 ST3GAL1 ST3GAL2 SLC35B3 SLC35B2 SLC35D2 ABCC5 HMMR SLC9A1 SLC26A1 SLC26A2 HSPG2 B4GALT1 BCAN SDC4 SDC2 HEXB SDC3 HEXA PRELP PAPSS2 GPC1 GPC3 GPC2 GPC5 GPC4 HS3ST3A1 CHST14 HS6ST1 GPC6 HS6ST2 ST3GAL3 HS2ST1 CHST6 HS6ST3 B3GAT3 NDST2 LUM NDST1 OMD NDST4 KERA NDST3 B3GALT6 ARSB EXT1 HS3ST3B1 GLCE EXT2 OGN HS3ST5 SDC1 HS3ST6 HS3ST4 FMOD HS3ST1 AGRN GNS B4GALT7 HS3ST2 PAPSS1 B4GALT2 DCN B4GALT3 B3GNT7 B3GNT4 B3GNT3 CHST1 ST3GAL6 B3GNT2 B4GALT6 CHST5 B4GALT4 CHST2 CD44 B4GALT5 CSGALNACT1 CHST7 CHPF CHPF2 NCAN CSGALNACT2 BGN ACAN VCAN GLB1 CHSY1 CHST11 NAGLU CHST12 CHST15 CSPG5 CSPG4 CHSY3 CHST13 CHST3 HPSE2 XYLT2 XYLT1 SGSH IDS GUSB IDUA B3GAT2 B3GAT1 GLB1L HPSE CEMIP HYAL1 STAB2 DSE HYAL3 LYVE1 DSEL HAS1 UST HYAL2 HAS3 SIGNALING BY NOTCH1 HD DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%2691230 Signaling by NOTCH1 HD Domain Mutants in Cancer UBB JAG2 NEURL1 UBC RPS27A JAG1 UBA52 ADAM10 NEURL1B ADAM17 DLL1 NOTCH1 MIB2 MIB1 DLL4 MITOCHONDRIAL UNCOUPLING%REACTOME DATABASE ID RELEASE 76%166187 Mitochondrial Uncoupling SLC25A27 UCP3 UCP2 UCP1 SLC25A14 PM20D1 SIGNALING BY TGF-BETA RECEPTOR COMPLEX%REACTOME%R-HSA-170834.1 Signaling by TGF-beta Receptor Complex CCNT1 WWTR1 SMAD4 SMAD3 SMURF2 SNW1 SP1 CDK9 E2F5 NEDD4L CCNT2 UCHL5 UBE2D3 TGIF1 MTMR4 PMEPA1 CDK8 BAMBI PPP1CB TGIF2 STRAP STUB1 PPP1R15A UBE2D1 SKIL JUNB FURIN CBL NEDD8 HDAC1 USP9X SMAD7 MEN1 RBL1 UBE2M E2F4 UBA52 USP15 TRIM33 XPO1 UBB PPM1A TFDP1 UBC TFDP2 RPS27A SKI RNF111 PPP1CC PARP1 NCOR2 NCOR1 MYC CCNK TGFB1 PPP1CA CCNC SMURF1 ARHGEF18 CGN F11R CDKN2B PRKCZ TGFBR1 RHOA TGFBR2 FKBP1A PARD6A SMAD2 SERPINE1 ATP1B4 PARD3 RECOGNITION AND ASSOCIATION OF DNA GLYCOSYLASE WITH SITE CONTAINING AN AFFECTED PURINE%REACTOME%R-HSA-110330.3 Recognition and association of DNA glycosylase with site containing an affected purine H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 MPG H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 NEIL3 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 MPS VII - SLY SYNDROME%REACTOME%R-HSA-2206292.3 MPS VII - Sly syndrome GUSB DEFECTIVE CHST6 CAUSES MCDC1%REACTOME DATABASE ID RELEASE 76%3656225 Defective CHST6 causes MCDC1 CHST6 LUM OMD KERA PRELP ACAN OGN FMOD RPIA DEFICIENCY: FAILED CONVERSION OF R5P TO RU5P%REACTOME%R-HSA-5659996.2 RPIA deficiency: failed conversion of R5P to RU5P RPIA ADRENALINE,NORADRENALINE INHIBITS INSULIN SECRETION%REACTOME%R-HSA-400042.2 Adrenaline,noradrenaline inhibits insulin secretion GNG3 GNG2 GNG5 GNG4 GNG7 GNG8 CACNA2D2 CACNB2 CACNB3 GNG10 GNG12 GNAI1 GNG11 GNAI2 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 ADRA2C ADCY6 GNGT1 ADCY5 ADRA2A GNGT2 CACNA1D CACNA1C DEFECTIVE GGT1 IN AFLATOXIN DETOXIFICATION CAUSES GLUTH%REACTOME%R-HSA-9035968.2 Defective GGT1 in aflatoxin detoxification causes GLUTH GGT1 SHC-MEDIATED CASCADE:FGFR2%REACTOME%R-HSA-5654699.1 SHC-mediated cascade:FGFR2 HRAS FGF1 FGF2 FGF3 FGF4 SOS1 FGF6 NRAS FGF7 FGF9 FGF20 FGF23 FGF22 FGF16 FGF18 FGF10 RESISTANCE OF ERBB2 KD MUTANTS TO AFATINIB%REACTOME DATABASE ID RELEASE 76%9665249 Resistance of ERBB2 KD mutants to afatinib HSP90AA1 CDC37 ERBB2 ERBIN COENZYME A BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%196783 Coenzyme A biosynthesis PPCDC COASY SLC25A16 PPCS PANK4 PANK2 PANK3 PANK1 TRANSLESION SYNTHESIS BY POLK%REACTOME%R-HSA-5655862.1 Translesion synthesis by POLK REV3L RFC5 UBB RFC3 UBC RFC4 POLK RFC2 RPS27A RFC1 PCNA RPA1 UBA52 RPA2 RPA3 REV1 MAD2L2 SEMA4D INDUCED CELL MIGRATION AND GROWTH-CONE COLLAPSE%REACTOME%R-HSA-416572.3 Sema4D induced cell migration and growth-cone collapse SEMA4D LIMK2 LIMK1 MYL6 MYH14 MYH11 ARHGEF11 MYL9 MYH10 ERBB2 ARHGEF12 MYH9 ROCK1 ROCK2 RND1 RHOC MYL12B RHOB PLXNB1 RHOA BIOSYNTHESIS OF PROTECTINS%REACTOME DATABASE ID RELEASE 76%9018681 Biosynthesis of protectins LTA4H ALOX15 CYP1A2 CYP1A1 SIGNALING BY CYTOSOLIC FGFR1 FUSION MUTANTS%REACTOME%R-HSA-1839117.2 Signaling by cytosolic FGFR1 fusion mutants STAT5A CUX1 STAT5B STAT1 CPSF6 ZMYM2 PIK3CA LRRFIP1 MYO18A PIK3R1 BCR GAB2 FGFR1OP2 STAT3 TRIM24 CEP43 DEFECTIVE ALG9 CAUSES ALG9-CDG (CDG-1L)%REACTOME DATABASE ID RELEASE 76%4720454 Defective ALG9 causes ALG9-CDG (CDG-1l) ALG9 SULFIDE OXIDATION TO SULFATE%REACTOME%R-HSA-1614517.2 Sulfide oxidation to sulfate SUOX SLC25A10 ETHE1 SQOR TSTD1 TST UPTAKE AND FUNCTION OF DIPHTHERIA TOXIN%REACTOME DATABASE ID RELEASE 76%5336415 Uptake and function of diphtheria toxin HSP90AA1 HBEGF CD9 EEF2 HSP90AB1 TXNRD1 TOXICITY OF BOTULINUM TOXIN TYPE D (BOTD)%REACTOME%R-HSA-5250955.2 Toxicity of botulinum toxin type D (botD) botD SV2C SV2B SV2A VAMP1 VAMP2 MET ACTIVATES STAT3%REACTOME%R-HSA-8875791.1 MET activates STAT3 HGF STAT3 MET TCR SIGNALING%REACTOME%R-HSA-202403.5 TCR signaling UBE2V1 TRAC CD3E GRAP2 TRBC1 PAG1 CDC34 TRBV12-3 TRAV29DV5 TRBV7-9 PAK3 TRAV19 BCL10 TRAV8-4 WAS CD4 PDPK1 PTPN22 CD101 PIK3R1 BTRC LAT PAK1 NFKB1 SKP1 PIK3R2 NCK1 FBXW11 TRAT1 ITK UBA52 CUL1 UBB CSK PTPRC UBC RPS27A CARD11 MALT1 EVL PRKCQ PIK3CA PLCG1 LCK PTPRJ VASP UBE2D2 CD3G LCP2 CD3D ENAH UBE2D1 ZAP70 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PTEN PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 INPP5D HLA-DQA2 PSMB6 HLA-DQA1 PSMB7 PSMB4 HLA-DRB5 PSMB5 HLA-DRB4 PSMB2 IKBKB PSMB3 HLA-DRB3 PSMB1 PSMF1 HLA-DRB1 CHUK PAK2 NFKBIA PSMB8 PIK3CB RELA PSMB9 SEM1 IKBKG PSMC5 PSMC6 HLA-DPA1 PSMC3 HLA-DQB2 PSMC4 HLA-DQB1 PSMC1 PSMC2 HLA-DPB1 FYB1 HLA-DRA RIPK2 TRAF6 UBE2N PLCG2 MAP3K7 TAB2 PHOSPHO-PLA2 PATHWAY%REACTOME%R-HSA-111995.1 phospho-PLA2 pathway MAPK1 PLA2G4A T41 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME%R-HSA-5358752.1 T41 mutants of beta-catenin aren't phosphorylated PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 BIOSYNTHESIS OF DPA-DERIVED SPMS%REACTOME%R-HSA-9018683.1 Biosynthesis of DPA-derived SPMs ALOX5 PTGS2 ALOX15 ALOX12 RHOU GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013420 RHOU GTPase cycle GIT2 DST RHOU USP9X TXNL1 VANGL1 DEPDC1B PEAK1 DLG5 SRGAP2 ARHGEF7 EPHA2 PAK4 ARHGEF6 PAK3 MYO6 STAM PAK2 HGS WWP2 CLTC ARHGAP30 STAM2 PIK3R1 IQGAP1 CDC42 PAK1 NCK2 WDR6 SPTAN1 PIK3R2 GIT1 SPTBN1 NCK1 SYNTHESIS OF PS%REACTOME DATABASE ID RELEASE 76%1483101 Synthesis of PS PTDSS2 PTDSS1 HUR (ELAVL1) BINDS AND STABILIZES MRNA%REACTOME%R-HSA-450520.2 HuR (ELAVL1) binds and stabilizes mRNA TNFSF13 PRKCD PRKCA SET ANP32A ELAVL1 XPO1 NUP214 METAL ION SLC TRANSPORTERS%REACTOME%R-HSA-425410.2 Metal ion SLC transporters SLC39A10 SLC39A14 SLC31A1 SLC11A2 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC30A2 SLC30A5 SLC30A1 SLC39A6 SLC39A5 SLC39A8 SLC30A10 SLC39A7 SLC41A2 SLC39A2 SLC41A1 SLC39A1 CP SLC39A3 SLC11A1 SLC40A1 HEPH SLC39A4 REMOVAL OF THE FLAP INTERMEDIATE FROM THE C-STRAND%REACTOME DATABASE ID RELEASE 76%174437 Removal of the Flap Intermediate from the C-strand POLD2 ACD TINF2 WRN TERF1 TERF2 PCNA RPA1 RPA2 POT1 TERF2IP RPA3 POLD3 FEN1 POLD4 POLD1 DNA2 PHASE II - CONJUGATION OF COMPOUNDS%REACTOME DATABASE ID RELEASE 76%156580 Phase II - Conjugation of compounds MGST3 MGST1 MGST2 SULT1A1 GSTT2B SULT1A4 SULT1A3 SULT1A2 ACSM1 GSTM4 GSTM3 ACSM2B GLYATL3 GSTZ1 GSTM2 GLYATL2 GSTM1 GLYATL1 SULT1B1 TPST2 TPST1 GSTM5 SULT1C2 SULT1C4 GSTO2 GSTO1 AKR1A1 UGDH GSTP1 SULT1E1 SLC35B3 SLC35B2 CYP1A2 GSS CHAC1 SLC35D1 GGT1 GSTA5 GSTA4 GSTA3 GSTA2 MTRR GSTA1 GGT3P UGT1A10 TPMT CNDP2 ABHD10 HPGDS UGT2B10 UGT2B11 UGT2B15 UGT2B17 SULT6B1 GSTT2 GSTT1 GLYAT ESD GGT5 UGT3A2 UGT3A1 COMT GGT7 GGT6 MAT2B GGCT GCLC NAT1 NAT2 GCLM PODXL2 ACSM2A SLC26A1 OPLAH UGT2A3 UGT2A2 UGT2A1 SULT4A1 UGT1A1 SLC26A2 ABHD14B UGT2B4 UGT2B7 PAPSS2 UGT2B28 UGP2 MAT2A UGT1A5 UGT1A4 BPNT2 BPNT1 UGT1A3 UGT1A9 UGT1A8 UGT1A7 UGT1A6 AHCY PAPSS1 N6AMT1 TRMT112 MAT1A NNMT MTR ACSM5 ACSM4 AS3MT CHAC2 SULT2A1 GSTK1 VITAMIN E%REACTOME DATABASE ID RELEASE 76%8877627 Vitamin E TTPA RHOT1 GTPASE CYCLE%REACTOME%R-HSA-9013425.1 RHOT1 GTPase cycle TRAK1 TRAK2 RAP1GDS1 MYO19 RHOT1 TOXICITY OF BOTULINUM TOXIN TYPE G (BOTG)%REACTOME%R-HSA-5250989.2 Toxicity of botulinum toxin type G (botG) SYT1 botG VAMP1 VAMP2 DEFECTIVE SRD5A3 CAUSES SRD5A3-CDG (CDG-1Q) AND KHRZ%REACTOME DATABASE ID RELEASE 76%4755579 Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ SRD5A3 ASSEMBLY OF THE ORC COMPLEX AT THE ORIGIN OF REPLICATION%REACTOME DATABASE ID RELEASE 76%68616 Assembly of the ORC complex at the origin of replication ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 RESISTANCE OF ERBB2 KD MUTANTS TO LAPATINIB%REACTOME DATABASE ID RELEASE 76%9665251 Resistance of ERBB2 KD mutants to lapatinib HSP90AA1 CDC37 ERBB2 ERBIN DEFECTIVE GALE CAN CAUSE EPIMERASE-DEFICIENCY GALACTOSEMIA (EDG)%REACTOME%R-HSA-5609977.2 Defective GALE can cause Epimerase-deficiency galactosemia (EDG) GALE REGULATION OF THYROID HORMONE ACTIVITY%REACTOME%R-HSA-350864.2 Regulation of thyroid hormone activity DIO1 DIO2 DIO3 UBIQUINOL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%2142789 Ubiquinol biosynthesis COQ5 COQ3 COQ2 COQ9 PDSS2 COQ7 PDSS1 COQ6 SIGNALING BY FGFR%REACTOME%R-HSA-190236.2 Signaling by FGFR BRAF GAB1 PIK3CA PLCG1 FRS3 SOS1 POLR2A POLR2B POLR2C MAPK1 POLR2D POLR2E POLR2F POLR2G POLR2H MAPK3 POLR2I POLR2J POLR2K PPP2CA POLR2L PPP2CB GTF2F1 GTF2F2 ANOS1 PTPN11 PTBP1 PPP2R1A PIK3R1 FLRT2 FLRT1 ESRP1 CBL HNRNPA1 FLRT3 TIAL1 TIA1 RBFOX2 ESRP2 MKNK1 FGFBP1 GALNT3 SPRY2 FGFBP2 FGFBP3 UBA52 FGFRL1 NCBP1 NCBP2 SPRED2 UBB KLB SPRED1 HRAS UBC HNRNPM FGF1 RPS27A HNRNPF FGF2 FGF3 FGF4 FGF6 NRAS FGF7 FGF9 FGF20 HNRNPH1 FGF23 FGF22 FRS2 FGF16 FGF19 FGF18 FGFR4 FGF10 MRNA CAPPING%REACTOME%R-HSA-72086.3 mRNA Capping CCNH RNMT POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 RNGTT GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 VIRAL MESSENGER RNA SYNTHESIS%REACTOME DATABASE ID RELEASE 76%168325 Viral Messenger RNA Synthesis NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 NUP35 NUP37 AAAS POLR2A NUP160 POLR2B POM121C POLR2C NUP85 POLR2D TPR POLR2E POLR2F NUP88 POLR2G POLR2H NUP155 POLR2I POLR2J POLR2K NUP214 NUP153 POLR2L PA PB2 NP GTF2F1 GTF2F2 PB1 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 PREGNENOLONE BIOSYNTHESIS%REACTOME%R-HSA-196108.2 Pregnenolone biosynthesis STARD3NL STARD6 STAR FDXR CYP11A1 AKR1B1 FDX1 TSPO TSPOAP1 STARD3 FDX2 STARD4 ETHANOL OXIDATION%REACTOME%R-HSA-71384.2 Ethanol oxidation ALDH1B1 ADH7 ADH5 ADH6 ADH1C ADH4 ADH1B ALDH1A1 ADH1A ACSS1 ACSS2 ALDH2 DEFECTIVE B3GALTL CAUSES PETERS-PLUS SYNDROME (PPS)%REACTOME DATABASE ID RELEASE 76%5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) SBSPON ADAMTS16 ADAMTS18 SSPOP SEMA5A B3GLCT ADAMTS12 ADAMTS10 ADAMTS4 THBS2 ADAMTS15 ADAMTS5 ADAMTS14 ADAMTSL1 ADAMTS13 THBS1 ADAMTSL5 ADAMTS1 ADAMTS19 ADAMTSL4 ADAMTSL3 ADAMTS17 ADAMTSL2 ADAMTS2 ADAMTS8 ADAMTS3 ADAMTS9 ADAMTS6 ADAMTS7 THSD1 THSD4 CFP SEMA5B ADAMTS20 THSD7B THSD7A SPON2 SPON1 CELL CYCLE%REACTOME%R-HSA-1640170.3 Cell Cycle PRKCB NOP10 MAPK1 HSP90AA1 CEP57 YWHAE KPNB1 CETN2 CEP164 CCP110 PPP1CB PCM1 ACTR1A TUBA1A PPP2R1A KIF20A CNTRL CEP250 NEK2 BTRC PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 SKP1 OFD1 PPP1R12A CEP135 BORA FBXW11 TUBB CEP131 ABL1 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 KIF18A AKAP9 CEP63 MAPRE1 SFI1 UBA52 AJUBA OPTN IST1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 CUL1 AURKA CCNB2 CCNB1 HAUS8 UBB HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 JAK2 TUBB4B TUBB4A NEDD1 CENPJ KIF23 ALMS1 CDK1 CEP41 CEP43 PIAS4 RAD51C KIF2A UBE2I KIF2C KIF2B RPS27 SUMO1 CABLES1 CENPE WEE1 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I H2AX POLR2J POLR2K H2AB1 H2AC19 POLR2L H2AC14 H2BC21 EP300 H2BU1 DSCC1 HJURP H3-3B RUVBL2 CDK7 H3C8 OIP5 H2AC8 SHQ1 PIF1 MNAT1 H2AC6 ANAPC15 CHTF8 H2AC7 ANAPC16 TERT CTC1 ANAPC7 H2BC17 RSF1 UBE2C H2BC12 UBE2E1 CHTF18 H2BC13 UBE2D1 MIS18BP1 ANAPC10 CHEK1 H2BC14 STN1 ANAPC11 CENPW CDC25A H2AJ CENPX CDC23 UBE2S H2BC15 TEN1 CDC26 MIS18A NUP107 CDC16 CDC27 NUP188 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 H3C15 BANF1 PSMD3 NUP210 PSMD1 PSMA5 RBBP4 NUP93 PSMA6 PSMA3 H2BS1 POM121 PSMA4 RBBP7 NUP205 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 H2AZ2 PSMD10 AAAS H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 POM121C PSMD14 NUP85 H2BC3 PSMD13 TPR SMARCA5 NUP88 PSMA7 H2BC1 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 H2AC20 PSMB4 NUP153 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NUP62 NDC1 ESCO1 CDCA5 NUP133 PDS5B ESCO2 PDS5A WAPL NUP50 NUP54 TUBB6 NEK9 TUBB3 NEK6 NUP42 TUBB1 NEK7 NUP43 VRK1 RAE1 CTDNEP1 RANBP2 CNEP1R1 RAN CDCA8 NUP35 SKA1 CSNK2A1 SKA2 NUP37 ANKLE2 CSNK2A2 TUBA4B CSNK2B NUF2 NUDC INCENP PRDM9 CENPA CENPC ACD CENPT TINF2 TERF1 CENPU TERF2 TUBA8 WRAP53 CENPH TUBA1C CENPI H3-4 TUBA1B POT1 TAOK1 TERF2IP CENPK CENPL CENPM TUBB2B TUBB2A CENPN CENPO HSP90AB1 CENPP CENPQ CENPS TUBAL3 HSPA2 TUBA3E TUBA3D TUBA3C CLIP1 MAD1L1 NDC80 SPDL1 RANGAP1 LYN NSL1 CDC20 DAXX PPP1CC ATRX KNL1 DSN1 RCC2 ZWINT AHCTF1 NDEL1 AKT3 LPIN1 LPIN2 LPIN3 MIS12 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 SFN MCM7 MCM8 SGO1 SKP2 SGO2 MCM3 MCM4 MCM5 MCM6 PMF1 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 BUB1 MSH4 MSH5 SIRT2 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SPO11 SYCP1 SYNE2 SYNE1 SUN2 SUN1 TEX12 TEX15 SMC1B E2F6 DMC1 PSMC3IP MND1 GINS1 MLH3 REC8 GINS2 CDC45 SYCP3 GINS3 GINS4 DHFR USO1 AKT2 MAU2 NIPBL UBE2N ANKRD28 FKBP6 PPP6C LBR EMD PPP6R3 RRM2 LEMD3 PPP2R2A RAB1A PPME1 PHLDA1 GTSE1 FKBPL RAB1B CDC25C VPS4A CDC25B TUBGCP2 HMMR PKMYT1 TPX2 TUBGCP5 TUBGCP6 TUBGCP3 TUBGCP4 FBXL7 LIN54 FOXM1 MYBL2 LIN52 TUBG2 MZT2B CDC7 MZT2A NME7 LIN37 LIN9 LCMT1 CDK11A FBXL18 PPP2R3B CDK11B MZT1 CENPF CDKN1C GOLGA2 RB1 RTEL1 CCND3 TFDP1 RUVBL1 CDK6 CCND2 TFDP2 CCND1 POLE CDK4 E2F1 LIG1 E2F2 RFC1 E2F3 MYC UBE2V2 CDKN2B ZW10 POLD3 POLD4 POLD1 POLD2 POLE4 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 RAB2A GORASP2 BLZF1 SEC13 NCAPG NCAPD2 SMC4 NCAPH SMC2 DYNC1I1 ITGB3BP CHMP4C CHMP4B CHMP4A MRE11 KAT5 NBN KMT5A HUS1 FEN1 DNA2 RHNO1 BLM PPP2R1B PPP2R5E BRIP1 ATRIP BARD1 BRCC3 PPP2R5B PPP2R5A PPP2R5D RAD17 CHMP2B PPP2R5C RAD9B CHMP2A ATR RAD9A BABAM1 BABAM2 YWHAQ BRCA1 UIMC1 YWHAH EXO1 PPP2CA TOPBP1 RFC5 PPP2CB RMI2 RFC3 RFC4 RFC2 RMI1 TOP3A GORASP1 WRN CHMP3 RBBP8 CHMP6 RPA1 CHMP7 RPA2 RAD50 RPA3 RAD1 DYNLL2 CLSPN SMC3 TUBB8 HERC2 SPAST TUBB8B LEMD2 CC2D1B RAD21 TP53BP1 GSK3B STAG1 STAG2 YWHAB SMC1A RNF168 XPO1 ABRAXAS1 AKT1 TNPO1 NUP214 PRKCA ARPP19 NCAPH2 YWHAZ NCAPG2 ENSA NCAPD3 CDC14A LMNB1 SET ESPL1 PTTG1 AURKB BRCA2 MASTL MCPH1 CDKN2D PPP2R2D CDKN2C RAD51 MDC1 EML4 NUMA1 CDKN1A CDKN1B PHF20 CHEK2 ZNF385A CCNA2 CCNA1 CCNE2 CCNE1 TP53 COP1 PCBP4 CDKN2A CDK2 MDM2 ATM MDM4 RBX1 PCNA TOP2A MAX E2F5 NPM1 MLH1 RNF8 NSD2 RCC1 BUB1B BUB3 MAD2L1 CKS1B GMNN FBXO5 DYRK1A MCM10 TK1 DBF4 TYMS RPA4 RBL2 RBL1 BIRC5 E2F4 DKC1 NHP2 PTK6 GAR1 PHENYLALANINE METABOLISM%REACTOME%R-HSA-8964208.1 Phenylalanine metabolism KYAT1 ASRGL1 QDPR IL4I1 PCBD1 PAH PAOS OXIDISE POLYAMINES TO AMINES%REACTOME%R-HSA-141334.2 PAOs oxidise polyamines to amines PAOX BETA OXIDATION OF OCTANOYL-COA TO HEXANOYL-COA%REACTOME%R-HSA-77348.2 Beta oxidation of octanoyl-CoA to hexanoyl-CoA HADHB HADH HADHA ECHS1 ACADM SUMOYLATION OF UBIQUITINYLATION PROTEINS%REACTOME DATABASE ID RELEASE 76%3232142 SUMOylation of ubiquitinylation proteins VHL NUP42 NUP210 NUP43 PIAS1 RAE1 MDM2 RANBP2 NUP93 POM121 SUMO1 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TRIM27 TPR NUP88 NUP155 PML NUP214 NUP153 SEC13 NUP62 NDC1 NUP133 NUP107 NUP188 PIAS4 NUP50 NUP54 UBE2I XENOBIOTICS%REACTOME%R-HSA-211981.1 Xenobiotics CYP3A7 AHR AHRR CYP2B6 CYP2A13 CYP2F1 CYP2C9 ARNT2 CYP2C8 CYP2D6 CYP3A43 CYP2C19 CYP1A2 ARNT CYP2C18 CYP2E1 CYP3A4 CYP2A7 CYP2A6 CYP2W1 CYP2J2 CYP2S1 CYP1A1 CYP3A5 FRS-MEDIATED FGFR1 SIGNALING%REACTOME%R-HSA-5654693.3 FRS-mediated FGFR1 signaling HRAS FGF1 FGF2 FGF3 FRS3 FGF4 SOS1 FGF6 NRAS PTPN11 FGF9 FGF20 FGF23 FGF22 FRS2 FGF10 NRIF SIGNALS CELL DEATH FROM THE NUCLEUS%REACTOME%R-HSA-205043.1 NRIF signals cell death from the nucleus PSEN1 UBB PSENEN NGF NCSTN UBC SQSTM1 RPS27A PSEN2 APH1A APH1B UBA52 ITGB3BP MAPK8 TRAF6 NGFR PDGFR MUTANTS BIND TKIS%REACTOME%R-HSA-9674428.1 PDGFR mutants bind TKIs PDGFRA IRAK1 RECRUITS IKK COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME DATABASE ID RELEASE 76%975144 IRAK1 recruits IKK complex upon TLR7 8 or 9 stimulation UBE2V1 IKBKB CHUK IRAK1 PELI3 PELI2 IKBKG TRAF6 UBE2N PELI1 ATTACHMENT AND ENTRY%REACTOME DATABASE ID RELEASE 76%9678110 Attachment and Entry ACE2 TMPRSS2 7a N 3a CTSL M E VCP S ESCAPE OF MTB FROM THE PHAGOCYTE%REACTOME%R-HSA-9637679.1 Escape of Mtb from the phagocyte cpnT NEUROPHILIN INTERACTIONS WITH VEGF AND VEGFR%REACTOME%R-HSA-194306.1 Neurophilin interactions with VEGF and VEGFR NRP2 NRP1 FLT1 KDR RNA POLYMERASE III ABORTIVE AND RETRACTIVE INITIATION%REACTOME DATABASE ID RELEASE 76%749476 RNA Polymerase III Abortive And Retractive Initiation POU2F1 CRCP ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP BRF2 GTF3A GTF3C1 GTF3C2 GTF3C3 NFIX GTF3C4 SSB GTF3C5 NFIA GTF3C6 NFIB BRF1 NFIC BDP1 POLR1C POLR1D EML4 AND NUDC IN MITOTIC SPINDLE FORMATION%REACTOME DATABASE ID RELEASE 76%9648025 EML4 and NUDC in mitotic spindle formation PPP2R1B KIF2C MIS12 PPP2R5E KIF2B NEK9 NEK6 NUP43 NEK7 RANBP2 RPS27 DYNC1LI1 DYNC1LI2 B9D2 PPP2R5B SPC24 CDCA8 PPP2R5A SPC25 ERCC6L PPP2R5D SKA1 CENPE PPP2R5C SKA2 NUP37 ZWILCH KNTC1 NUF2 SGO1 NUDC SGO2 PPP2CA PMF1 PPP2CB INCENP CENPA CENPC BUB1B CENPT BUB3 CENPU SEC13 MAD2L1 PPP2R1A CENPH CENPI TAOK1 CENPK CENPL BUB1 CENPM NUP107 CENPN DYNLL2 CENPO CENPP CENPQ CENPS DYNC1I1 DYNLL1 CKAP5 CLIP1 KIF18A MAD1L1 BIRC5 MAPRE1 NDC80 ITGB3BP NUP160 PAFAH1B1 DYNC1I2 NUP85 SPDL1 XPO1 CENPF RANGAP1 CLASP2 NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 EML4 RCC2 NUP133 ZWINT AHCTF1 ZW10 NDEL1 KIF2A DEFECTIVE B3GALT6 CAUSES EDSP2 AND SEMDJL1%REACTOME%R-HSA-4420332.1 Defective B3GALT6 causes EDSP2 and SEMDJL1 GPC5 GPC4 CSPG5 GPC6 CSPG4 B3GALT6 DCN SDC1 AGRN HSPG2 SDC4 BCAN SDC2 SDC3 NCAN BGN GPC1 VCAN GPC3 GPC2 TRANSPORT OF NUCLEOTIDE SUGARS%REACTOME%R-HSA-727802.1 Transport of nucleotide sugars SLC35A2 SLC35A1 SLC35B3 SLC35A3 SLC35B2 SLC35C1 SLC35B4 SLC35D1 SLC35D2 ANTIVIRAL MECHANISM BY IFN-STIMULATED GENES%REACTOME DATABASE ID RELEASE 76%1169410 Antiviral mechanism by IFN-stimulated genes OAS1 OAS2 OAS3 KPNA7 KPNA4 NUP42 KPNA5 USP41 NUP43 KPNA2 EIF4E2 RAE1 KPNA3 RANBP2 PLCG1 EIF2AK2 NUP35 EIF4A3 NUP37 MX2 MX1 ABCE1 MAPK3 KPNA1 STAT1 UBA7 NS KPNB1 UBE2L6 NEDD4 HERC5 FLNA SEC13 UBE2E1 ISG15 IRF3 NUP107 PIN1 NUP188 JAK1 EIF4A2 NUP210 EIF4A1 NUP93 POM121 IFIT1 NUP205 UBA52 AAAS NUP160 POM121C NUP85 TPR PDE12 NUP88 NUP155 EIF4E NUP214 NUP153 USP18 UBB UBC DDX58 TRIM25 RPS27A ARIH1 RNASEL NUP62 gag FLNB NDC1 NUP133 EIF4G3 EIF4G1 EIF4G2 EIF4E3 OASL NUP50 NUP54 UBE2N PPM1B PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS%REACTOME DATABASE ID RELEASE 76%202427 Phosphorylation of CD3 and TCR zeta chains TRAC CD3E TRBC1 LCK PAG1 TRBV12-3 TRAV29DV5 TRBV7-9 PTPRJ TRAV19 TRAV8-4 HLA-DQA2 HLA-DQA1 HLA-DRB5 CD4 HLA-DRB4 CSK HLA-DRB3 PTPRC HLA-DRB1 CD3G CD3D PTPN22 HLA-DPA1 HLA-DQB2 HLA-DQB1 HLA-DPB1 HLA-DRA DEFECTIVE GCK CAUSES MATURITY-ONSET DIABETES OF THE YOUNG 2 (MODY2)%REACTOME DATABASE ID RELEASE 76%5619073 Defective GCK causes maturity-onset diabetes of the young 2 (MODY2) GCK DISEASES ASSOCIATED WITH SURFACTANT METABOLISM%REACTOME%R-HSA-5687613.2 Diseases associated with surfactant metabolism SFTPA2 SFTPA1 SLC34A2 SFTPC CSF2RB SFTPB SFTPD CSF2RA ABCA3 SFTA3 NEUROTRANSMITTER CLEARANCE%REACTOME DATABASE ID RELEASE 76%112311 Neurotransmitter clearance ACHE LRTOMT BCHE SLC22A2 SLC22A1 SLC6A4 MAOA COMT SLC6A3 ALDH2 BLOCH PATHWAY%REACTOME%R-HSA-6807047.1 Bloch pathway SC5D DHCR7 EBP DHCR24 SYNTHESIS OF LIPOXINS (LX)%REACTOME DATABASE ID RELEASE 76%2142700 Synthesis of Lipoxins (LX) ALOX5 ALOX12 LTC4S ALOX5AP HPGD PTGR1 APC C:CDC20 MEDIATED DEGRADATION OF SECURIN%REACTOME DATABASE ID RELEASE 76%174154 APC C:Cdc20 mediated degradation of Securin ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PTTG1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DEFECTIVE SLC12A6 CAUSES AGENESIS OF THE CORPUS CALLOSUM, WITH PERIPHERAL NEUROPATHY (ACCPN)%REACTOME%R-HSA-5619039.1 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) SLC12A6 BUTYRATE RESPONSE FACTOR 1 (BRF1) BINDS AND DESTABILIZES MRNA%REACTOME DATABASE ID RELEASE 76%450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 DCP2 ZFP36L1 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A AKT1 DEFECTIVE GALNT12 CAUSES COLORECTAL CANCER 1 (CRCS1)%REACTOME%R-HSA-5083636.1 Defective GALNT12 causes colorectal cancer 1 (CRCS1) MUC4 MUC6 MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 MUC19 MUC20 MUC21 MUCL1 MUC5B MUC5AC MUC1 GALNT12 MUC2 MUC13 MUC7 RETINOID CYCLE DISEASE EVENTS%REACTOME%R-HSA-2453864.2 Retinoid cycle disease events TTR ABCA4 OPN1LW LRAT OPN1MW RBP4 NAPEPLD STRA6 RBP1 RLBP1 RDH5 OPN1SW RDH12 SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)%REACTOME DATABASE ID RELEASE 76%162710 Synthesis of glycosylphosphatidylinositol (GPI) PIGO PIGN PIGP PIGZ PIGW PIGV PIGY PIGX PIGC PIGB PIGA PIGM PIGL PIGG PIGF PIGH DPM2 INSULIN EFFECTS INCREASED SYNTHESIS OF XYLULOSE-5-PHOSPHATE%REACTOME DATABASE ID RELEASE 76%163754 Insulin effects increased synthesis of Xylulose-5-Phosphate TALDO1 TKT DEFECTIVE DNA DOUBLE STRAND BREAK RESPONSE DUE TO BRCA1 LOSS OF FUNCTION%REACTOME DATABASE ID RELEASE 76%9663199 Defective DNA double strand break response due to BRCA1 loss of function BRCA1 BARD1 GDP-FUCOSE BIOSYNTHESIS%REACTOME%R-HSA-6787639.1 GDP-fucose biosynthesis FPGT SLC35C1 FUOM GFUS GMDS FCSK OTHER INTERLEUKIN SIGNALING%REACTOME%R-HSA-449836.10 Other interleukin signaling CD4 PTPRZ1 STX4 CSF1R IFNL1 SNAP25 IL10RB IFNLR1 IL16 IL34 STX1A STXBP2 TYK2 SDC1 IL32 PRTN3 VAMP2 CSF3R STX3 CASP3 TXLNA JAK1 CSF1 CSF3 RAS GTPASE CYCLE MUTANTS%REACTOME%R-HSA-9649913.1 RAS GTPase cycle mutants HRAS NRAS KRAS DEFECTIVE SLC7A9 CAUSES CYSTINURIA (CSNU)%REACTOME DATABASE ID RELEASE 76%5660883 Defective SLC7A9 causes cystinuria (CSNU) SLC3A1 SLC7A9 DEFECTIVE SLC6A2 CAUSES ORTHOSTATIC INTOLERANCE (OI)%REACTOME%R-HSA-5619109.1 Defective SLC6A2 causes orthostatic intolerance (OI) SLC6A2 CELL-CELL JUNCTION ORGANIZATION%REACTOME DATABASE ID RELEASE 76%421270 Cell-cell junction organization PATJ CTNNA1 CLDN2 CLDN1 CDH9 CTNNB1 CDH8 CDH7 CDH6 CDH3 CLDN6 CLDN4 CLDN3 CLDN9 CLDN8 JUP CLDN7 CDH24 CADM2 SDK1 SDK2 CLDN22 CLDN20 CLDN23 PRKCI CLDN5 ANG CLDN11 CLDN10 CLDN15 CLDN14 CDH10 CLDN12 CDH11 CLDN19 CDH12 CLDN18 CDH13 CLDN17 CLDN16 CDH17 CDH18 PARD6G PARD6B CTNND1 MPP5 CDH4 CRB3 CDH15 CDH2 CDH5 CDH1 CADM3 CADM1 NECTIN4 NECTIN3 PVR NECTIN2 NECTIN1 F11R PARD6A PARD3 INTRA-GOLGI TRAFFIC%REACTOME DATABASE ID RELEASE 76%6811438 Intra-Golgi traffic CYTH2 CYTH4 CUX1 MAN1C1 CYTH1 RGP1 YKT6 ALPP TRIP11 RAB39A VPS45 VTI1A MAN1A2 MAN1A1 STX6 STX5 MAN2A1 RIC1 GOLGA5 NSF GOLIM4 RAB41 SNAP29 COG8 ARF1 COG7 COG6 RAB30 COG5 COG4 COG3 RAB36 RAB33B COG2 COG1 BET1L NAPA NAPB GOSR2 MAN2A2 GOSR1 STX16 NAPG CYTH3 MPS VI - MAROTEAUX-LAMY SYNDROME%REACTOME DATABASE ID RELEASE 76%2206285 MPS VI - Maroteaux-Lamy syndrome ARSB PLATELET CALCIUM HOMEOSTASIS%REACTOME%R-HSA-418360.1 Platelet calcium homeostasis ATP2A1 SLC8A1 SLC8A2 TRPC7 TRPC6 TRPC3 STIM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 SRI ATP2B4 ATP2B3 ATP2B2 ATP2B1 P2RX7 SLC8A3 P2RX6 P2RX5 P2RX4 P2RX3 P2RX2 P2RX1 CALM1 ATP2A3 ATP2A2 ROS SENSING BY NFE2L2%REACTOME DATABASE ID RELEASE 76%8932339 ROS sensing by NFE2L2 KEAP1 RBX1 CSNK2A1 CSNK2A2 CSNK2B NFE2L2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PRKCD PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SIGNALING BY MET%REACTOME%R-HSA-6806834.2 Signaling by MET GAB1 RAB4A PIK3CA SOS1 TNS4 TNS3 ITGB1 LAMC2 LAMC1 LAMC3 PTPRJ STAM ITGA3 LAMA4 SH3KBP1 CRKL HGF RANBP10 HGS HGFAC PTPN11 RANBP9 PIK3R1 RAPGEF1 LAMA5 USP8 LAMA3 CBL LAMB3 LAMB1 EPS15 SPINT1 CRK HPN LRIG1 PTPN2 SPINT2 MUC20 PTPN1 UBA52 ARF6 LAMA2 LAMA1 STAT3 SH3GL3 GGA3 DOCK7 UBB RAB4B PTK2 HRAS SH3GL2 SH3GL1 UBC RPS27A NRAS RAP1B RAP1A RAC1 STAM2 ITGA2 MET LAMB2 SRC VPR-MEDIATED INDUCTION OF APOPTOSIS BY MITOCHONDRIAL OUTER MEMBRANE PERMEABILIZATION%REACTOME DATABASE ID RELEASE 76%180897 Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization SLC25A5 SLC25A4 SLC25A6 vpr SIGNALING BY RECEPTOR TYROSINE KINASES%REACTOME%R-HSA-9006934.5 Signaling by Receptor Tyrosine Kinases PRKCB BRAF DIAPH1 TNS4 ADAM12 TNS3 PAG1 FYN LAMC3 PAK3 ATP6V1H MAPK1 ITGA3 MAPK3 LAMA4 HSP90AA1 HGF CDC37 ERBB2 ERBIN HGS PPP2R1A PRKACA ESRP1 FLRT3 PTPRK LRIG1 SPRY1 MUC20 CDK5 UBA52 MAP2K1 MAP2K2 IRS4 SHC3 DOCK3 NCBP1 NCBP2 RAB4B UBB DOCK7 UBC RPS27A ITGB3 ITGAV RAC1 JAK2 ITGA2 MET WASF3 ESR1 NELFB DOCK1 FLT3 SH2B3 SH2B2 LCK PGR GRB7 POLR2A THBS2 GRIN2B POLR2B PTPRJ POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I DLG4 POLR2J POLR2K POLR2L NRP1 CHD4 GTF2F1 EP300 GTF2F2 NEDD4 STUB1 CLTA AP2A1 RANBP9 PCSK6 CHEK1 AP2A2 PCSK5 AP2M1 FES GALNT3 AP2S1 APOE LAMA1 MAPK12 AP2B1 MAPK13 PAK2 VGF PRKCE PTPN12 CUL5 RAP1B RAP1A LAMB2 NGF FRS3 JUP VAV3 VAV1 ELMO2 RNF41 RRAD ASCL1 LYL1 JUND EGR3 EGR4 FOSL1 ARC ID2 ANOS1 ID4 FOSB KIDINS220 ID3 TRIB1 CDK5R2 SPHK1 SHB CDH5 WWP1 SH2D2A PTK2B AXL STAT3 LYN YES1 SRF FLT1 PTK2 FLT4 CSK VEGFB KDR VEGFC VEGFD PGF VEGFA AKT3 PTPRS TCIRG1 SHC1 GAB1 CTNNA1 PIK3CA PLCG1 SOS1 IGF1 SHC2 AREG RALGDS DNAL4 ATP6V1E1 RALB RIT1 ATP6V1E2 RIT2 ATP6V1G1 IGF2 ATP6V1G2 IGF1R ATP6V0E1 EPS15L1 NRG1 NRG2 NRG3 ATP6V0D1 NRG4 ATP6V0D2 ELMO1 CRK ATP6V0A2 PXN ATP6V0A4 PTPN1 HBEGF BCAR1 ATP6V1C1 ARF6 ATP6V0A1 ATP6V1C2 EGFR AKT2 MLST8 GGA3 STAT5A MTOR STAT5B ATP6V0B PTPN3 S100B ATP6V0C COL4A2 COL4A1 COL4A4 TAB2 SOCS6 COL6A2 COL4A3 ATP6V1G3 ATP6V0E2 COL6A1 RAB4A CXCL12 COL4A5 COL6A3 AAMP COL6A6 COL6A5 ITGB1 CYFIP1 NCKAP1 NCF1 KIT MEF2A NCF2 MEF2C ELK1 NCF4 RPS6KA3 BRK1 RPS6KA5 RPS6KA2 RPS6KA1 NTRK3 ATP6V1A NTF3 PDGFB CRKL PDGFRB STAT1 ATP6V1D ATP6V1F CYBB CYBA VAV2 TIAM1 JUNB RAPGEF1 GRB10 ADORA2A TRIB3 PIK3R2 ATP6AP1 ATP6V1B2 ATP6V1B1 PTPN2 NCKAP1L WASF1 TIAL1 TIA1 RBFOX2 WASF2 ESRP2 FGFBP1 FGFBP2 FGFBP3 CAV1 BAIAP2 ABI2 ABI1 TCF12 HNRNPM HNRNPF HNRNPH1 WWOX ADAM10 ADAM17 EREG PLAT ATF2 BTC THBS4 YAP1 THBS3 PDGFD SRC PSEN1 NCSTN TGFA COL9A1 CTNNB1 COL9A3 COL9A2 MEF2D LAMC2 LAMC1 PTPRU FER TEC STAM GRAP SH3KBP1 RANBP10 MMP9 PSEN2 APH1A PTBP1 APH1B FLRT2 FLRT1 LAMA5 SOCS1 LAMA3 FURIN PLG SPP1 LAMB3 CMA1 PSENEN NAB1 LAMB1 NAB2 HNRNPA1 EPS15 EGR2 MKNK1 EPGN SPRY2 F3 STAT6 LAMA2 SH3GL3 ATF1 KLB IRS1 MAPKAPK3 SH3GL2 PDE3B PIK3R4 SH3GL1 IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 GFAP FGF20 THEM4 STAM2 FGF23 FGF22 INSR FLT3LG FRS2 GAB2 FGF16 FGF19 FGF18 TLR9 PIK3C3 FGFR4 FGF10 GABRB3 GABRB2 GABRB1 PPP2R1B MAPKAP1 GABRG3 GABRG2 GABRQ GABRA1 GRAP2 PPP2R5D PRR5 THBS1 ITPR1 ITPR2 ITPR3 EPN1 DNM1 PPP2CA DNM2 PPP2CB DNM3 HGFAC NOS3 PDPK1 SGK1 PTPN11 CLTC RICTOR PTPRO PIK3R1 CSN2 STMN1 ADAP1 CDC42 PAK1 MXD4 RALA USP8 NCK2 PTPN6 CALM1 CBL PTPN18 CDK5R1 NTRK1 MATK INS NCK1 NTRK2 ADCYAP1 ADCYAP1R1 MEMO1 ARHGEF7 EGF CILP YWHAB HSPB1 FGFRL1 AKT1 DUSP4 TPH1 DUSP3 VRK3 DUSP6 PRKCD DUSP7 PRKCA MAPK7 MAPKAPK2 CREB1 NCOR1 MAPK14 MAPK11 ID1 PRKACG PRKACB FOS NTF4 BDNF CTNND1 NRP2 ITCH REST MAP2K5 SPINT1 MST1 HPN MST1R SPINT2 ROCK1 ROCK2 BAX CYFIP2 AHCYL1 EGR1 SPRED2 SPRED1 HRAS PDGFRA RASA1 NRAS PTK6 SPARC PIK3R3 PRKCZ RHOA POLYMERASE SWITCHING ON THE C-STRAND OF THE TELOMERE%REACTOME%R-HSA-174411.4 Polymerase switching on the C-strand of the telomere POLD2 PRIM2 PRIM1 POLA1 POLA2 PCNA RFC5 RFC3 RFC4 RFC2 DSCC1 ACD RFC1 TINF2 CHTF8 TERF1 TERF2 CTC1 CHTF18 STN1 POT1 TERF2IP TEN1 POLD3 POLD4 POLD1 UBIQUITIN-DEPENDENT DEGRADATION OF CYCLIN D%REACTOME%R-HSA-75815.3 Ubiquitin-dependent degradation of Cyclin D PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 GSK3B PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 CCND1 RPS27A SEM1 PSMC5 CDK4 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SIGNALING BY RHO GTPASES%REACTOME DATABASE ID RELEASE 76%194315 Signaling by Rho GTPases FAM169A TOR1AIP1 AKAP12 PRKCB BAIAP2L2 BASP1 POTEE FARP1 ACTN1 RHOF SENP1 DIAPH1 DIAPH2 PAK3 MAPK1 MAPK3 TWF1 WAS KDM1A HSP90AA1 DOCK11 CDC37 KIF5B ERBIN KIF5A HGS YWHAE CCP110 RAB7A PPP1CB MYO9B PPP2R1A YWHAG KLC1 PPP1R12A KLC4 KLC3 KLC2 MYL6 MYL9 ABL1 DYNLL1 CKAP5 NCKIPSD FARP2 KIF18A PLXND1 MAPRE1 DVL1 DVL3 PAFAH1B1 DOCK6 DYNC1I2 DOCK5 DOCK4 DOCK3 PLXNA1 DOCK9 SRGAP3 DOCK8 SRGAP1 DOCK7 CAPZB CLASP1 DYNC1H1 NDE1 RAC1 PLK1 EVL KIF2A WASF3 KIF2C KIF2B DOCK2 DOCK1 AR RPS27 LCK CENPE PFN1 PFN2 RASGRF2 GRB7 MYL12B LIN7B H2AX DLG4 H2AB1 H2AC19 ACTB H2AC14 H2BC21 PREX2 H2BU1 WWP2 H3-3B H3C8 H2AC8 PAK5 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 NUP107 H2BC11 MYH14 MYH11 MYH10 H3C15 ARHGAP10 H2BS1 VCP RND1 H2AZ1 H2BC9 H2AZ2 AAAS H4C9 H2BC8 H2BC5 NUP160 NUP85 H2BC3 H2BC1 H2AC20 CLASP2 PAK2 UACA NUP133 STMN2 MYLK WDR91 EPSTI1 NUP43 ANKFY1 STARD8 RANBP2 MRTFA FRS3 WDR81 DAAM1 CDCA8 IQGAP3 SKA1 SKA2 NUP37 ANKLE2 STARD13 ARHGDIG JUP ARHGDIA FAM135A MCF2L CDC42SE2 VAV3 ARHGAP9 PLEKHG3 ARHGAP8 ARHGEF16 OSBPL11 RHOG ARHGAP4 VAV1 LRRC1 NDUFS3 NUF2 ELMO2 NUDC ARHGEF5 RRAS2 ARHGEF26 SHMT2 GMIP PLD1 IQGAP2 CIT CDC42EP5 KALRN HMOX2 INCENP NDUFA5 CDC42EP3 CCT6A HSPE1 CDC42EP2 LETM1 PKN3 VAPB CENPA MAP3K11 CENPC FGD5 CHN2 CHN1 FLNA CENPT CENPU KIDINS220 WDR11 TMEM59 CENPH CENPI TUBA1B SHKBP1 TAOK1 CENPK CENPL CENPM GOPC PKN2 FILIP1 CENPN PKN1 CENPO HSP90AB1 CENPP STIP1 CENPQ CENPS UHRF1BP1L FAM13B FAM13A MSI2 STK10 SLK MEN1 GOLGA8R RALGAPA1 FAM91A1 TEX2 CLIP1 PHIP MAD1L1 RHOBTB2 DDRGK1 NDC80 NSFL1C NF2 ARHGAP11A ARHGAP11B TAGAP EFHD2 SPDL1 PLEKHG4 DDX4 ARHGEF28 ARPC1B PLEKHG1 TNFAIP1 PLEKHG6 ACTG1 RND3 CFL1 RANGAP1 FLOT2 NIPSNAP2 MUC13 PPP1R12B FAM83B DSP SRF LIMK2 ANKRD26 NSL1 LIMK1 PLEKHG5 SH3BP1 PTK2 CSK CDC20 TMOD3 WHAMM SEMA4F SCRIB PPP1R14A PCDH7 PTPN13 CDC42BPB CKAP4 KTN1 CDC42BPA NISCH PRC1 CCDC88A VANGL2 PPP1CC CPNE8 GOLGA3 UBXN11 CPD KNL1 SPATA13 KCTD13 DSG1 ROPN1 PKP4 TMEM87A KLK3 PICALM DSN1 SCAI RCC2 ZWINT ANLN AHCTF1 ITSN1 FAF2 FNBP1L KIF14 HINT2 GJA1 SH3PXD2A NDEL1 CCDC115 RHOH RHOD RHOJ TAX1BP3 RHOU MIS12 PLEKHG4B EMC3 FNBP1 CTNNA1 PIK3CA BCAP31 CAVIN1 DYNC1LI1 SOS1 DLC1 DYNC1LI2 B9D2 SPC24 TJP2 SPC25 ERCC6L RTKN PRAG1 ZWILCH SYDE2 ARHGAP44 ARHGAP40 KNTC1 RALBP1 KCTD3 SFN ARHGAP45 ALDH3A2 SGO1 SGO2 ARHGEF25 ARHGAP19 ARHGAP18 PMF1 ARHGAP22 ARHGAP20 RHPN1 RHPN2 ACBD5 ARHGAP29 MACO1 ARHGAP28 ARHGAP27 ARHGAP25 ARHGAP24 ARHGAP23 ARHGAP33 ARHGAP31 ARPC1A ARHGAP30 DNMBP RND2 ZAP70 GFOD1 CCDC187 MOSPD2 BUB1 KDM4C FMNL3 FMNL1 FMNL2 ACTC1 STX5 LAMTOR1 DVL2 GNA13 ITGB1 CYFIP1 NCKAP1 TRIO ARPC4 TFRC NCF1 NCF2 ARPC5 SNAP23 NCF4 ARHGAP1 BRK1 ARHGAP39 ARHGAP5 ARPC2 ARHGAP6 ARPC3 ARHGAP35 DOCK10 PREX1 SYDE1 ARHGAP42 BAIAP2L1 OPHN1 STBD1 ARHGDIB RAC3 LBR EMD TMPO SWAP70 ARAP2 ARAP3 CYBB ACTR2 CYBA OCRL VRK2 LEMD3 VAV2 BCR ARFGAP3 TIAM1 ABCD3 RAPGEF1 CDC42EP1 DSG2 VAMP3 ARFGAP2 GARRE1 AMIGO2 NOXO1 ARHGAP17 PIK3R2 ATP6AP1 SLC1A5 ARHGAP15 LMAN1 CDC25C ARHGAP21 ABR PGRMC2 RACGAP1 SLITRK3 NHS SLITRK5 ABL2 NCKAP1L WASF1 ADD3 SRGAP2 WASF2 YKT6 PAK4 IL32 JAG1 CAV1 MCAM MCF2 STOM BAIAP2 ARHGAP26 MPP7 ARHGAP32 SLC4A7 DIAPH3 ABI2 TAOK3 ABI1 CENPF NOXA1 NOX3 ESYT1 NOX1 FERMT2 CDH1 ARL13B ZW10 KLK2 CFTR SCFD1 CTNNB1 STAM ARHGEF40 DDX39B TIAM2 OBSCN NGEF SEC13 ECT2 CTTN ARHGEF39 RHOQ NET1 PIN1 ARHGEF10L AKAP13 C1QBP ARHGEF11 ARHGEF10 PLEKHG2 DYNC1I1 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 TRIP10 SOS2 ITGB3BP ARHGEF6 FGD1 FGD2 FGD3 FGD4 PIK3R4 NCOA2 STAM2 S100A9 S100A8 FRS2 PIK3C3 PPP2R1B PPP2R5E PPP2R5B PPP2R5A PPP2R5D PPP2R5C YWHAQ YWHAH PPP2CA PPP2CB PDPK1 ALS2 MYH9 ZNF512B CLTC WASL PIK3R1 IQGAP1 SH3RF1 ARHGAP12 CDC42 PAK1 NCK2 PAK6 WDR6 CALM1 CEP97 SPTAN1 DYNLL2 GIT1 SPTBN1 NCK1 GIT2 TPM4 DST USP9X TPM3 TXNL1 MYO9A VANGL1 DEPDC1B PEAK1 DLG5 RHOV ARHGEF7 EPHA2 YWHAB XPO1 PRKCD PRKCA YWHAZ LMNB1 AURKB MAPK14 MAPK11 CDKN1B BTK RHOC RHOB STEAP3 FLOT1 CKB BUB1B BUB3 MAD2L1 SPEN RNF20 CCT2 CPSF7 ROCK1 ROCK2 CUL3 BIRC5 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 CYFIP2 MYO6 PDE5A RBBP6 VIM HNRNPC WIPF1 CCT7 WIPF2 MTR RBMX DBN1 WIPF3 DBT RASAL2 RAC2 ARAP1 ARMCX3 CDC42EP4 PIK3R3 PLD2 ARHGEF18 SAMM50 MTX1 PRKCZ DEF6 RHOA PARD6A MTMR1 SOWAHC PROLONGED ERK ACTIVATION EVENTS%REACTOME%R-HSA-169893.1 Prolonged ERK activation events CRKL NGF BRAF CRK KIDINS220 RAP1A MAP2K1 FRS2 RAPGEF1 MAP2K2 YWHAB MAPK1 MAPK3 NTRK1 REVERSIBLE HYDRATION OF CARBON DIOXIDE%REACTOME%R-HSA-1475029.1 Reversible hydration of carbon dioxide CA7 CA6 CA12 CA14 CA13 CA5B CA5A CA1 CA2 CA4 CA3 CA9 MATURATION OF NUCLEOPROTEIN%REACTOME DATABASE ID RELEASE 76%9694631 Maturation of nucleoprotein GSK3B PARP4 PARP16 PARP9 PARP14 N PARP8 SUMO1 PARP10 UBE2I PARP6 BASE EXCISION REPAIR%REACTOME%R-HSA-73884.2 Base Excision Repair POLD2 XRCC1 POLE4 POLE2 POLE3 PCNA MPG H2AX H2AB1 H2AC19 RFC5 H2AC14 RFC3 H2BC21 RFC4 RFC2 OGG1 H2BU1 NTHL1 TDG H2AC8 MBD4 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 SMUG1 H2BC12 NEIL3 H2BC13 NEIL2 RPA1 H3-4 H2BC14 POT1 RPA2 H2AJ TERF2IP NEIL1 H2BC15 PARG APEX1 ADPRS RPA3 H2BC11 POLB H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 PNKP H2AC20 POLE LIG1 PARP1 RFC1 PARP2 LIG3 POLD3 FEN1 POLD4 POLD1 ACTIVATION OF NOXA AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111448.2 Activation of NOXA and translocation to mitochondria TP53 TFDP1 TFDP2 E2F1 PMAIP1 INWARDLY RECTIFYING K+ CHANNELS%REACTOME DATABASE ID RELEASE 76%1296065 Inwardly rectifying K+ channels KCNJ1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 KCNJ8 GNG2 KCNJ11 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ14 KCNJ15 GNG8 KCNJ16 GABBR2 GABBR1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 ABCC8 ABCC9 IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION%REACTOME%R-HSA-975163.1 IRAK2 mediated activation of TAK1 complex upon TLR7 8 or 9 stimulation TAB1 UBB TICAM2 UBC LY96 TICAM1 RPS27A CD14 TLR4 UBA52 IRAK2 TRAF6 TAB3 TAB2 MAP3K7 ION TRANSPORT BY P-TYPE ATPASES%REACTOME%R-HSA-936837.3 Ion transport by P-type ATPases ATP2A1 ATP7B PDZD11 ATP1B3 ATP1B2 ATP10D ATP1B1 ATP10B ATP10A PLN SRI ATP9B ATP9A ATP2B4 ATP2B3 ATP2B2 FXYD4 ATP2B1 FXYD3 FXYD2 FXYD1 FXYD7 FXYD6 CALM1 ATP1A4 ATP1A3 ATP1A2 ATP1A1 ATP2C2 ATP2C1 ATP8A2 ATP8A1 ATP12A ATP13A1 SLN ATP4B ATP4A ATP7A ATP13A4 ATP13A5 ATP13A2 CUTC CAMK2B CAMK2D ATP11C CAMK2A ATP11B ATP11A CAMK2G ATP8B4 ATP8B3 ATP8B2 ATP8B1 ATP2A3 ATP2A2 NUCLEAR EVENTS (KINASE AND TRANSCRIPTION FACTOR ACTIVATION)%REACTOME DATABASE ID RELEASE 76%198725 Nuclear Events (kinase and transcription factor activation) PPP2R1B ID1 FOS PPP2R5D MEF2D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 DNM2 PPP2CA CHD4 PPP2CB RRAD ASCL1 LYL1 EP300 JUND EGR3 EGR4 FOSL1 ARC SGK1 ID2 ID4 FOSB ID3 PPP2R1A TRIB1 CDK5R2 JUNB CDK5R1 REST NAB1 NAB2 EGR2 F3 CDK5 SH3GL3 DUSP4 ATF1 DUSP3 TPH1 VRK3 EGR1 DUSP6 SRF TCF12 DUSP7 MAPK7 MAPKAPK2 VGF CREB1 MAPK14 MAPK11 ATF2 ACETYLCHOLINE BINDING AND DOWNSTREAM EVENTS%REACTOME DATABASE ID RELEASE 76%181431 Acetylcholine binding and downstream events CHRNA6 CHRNB4 CHRND CHRNA9 CHRNG CHRNE CHRNB2 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 LOSS OF FUNCTION OF SMAD2 3 IN CANCER%REACTOME%R-HSA-3304349.2 Loss of Function of SMAD2 3 in Cancer TGFB1 SMAD4 SMAD3 TGFBR1 TGFBR2 SMAD2 TYPE I HEMIDESMOSOME ASSEMBLY%REACTOME%R-HSA-446107.1 Type I hemidesmosome assembly LAMC2 LAMB3 ITGA6 DST PLEC CD151 ITGB4 LAMA3 COL17A1 INTERLEUKIN-21 SIGNALING%REACTOME DATABASE ID RELEASE 76%9020958 Interleukin-21 signaling STAT5A IL21 STAT5B STAT1 IL21R IL2RG JAK3 STAT3 STAT4 JAK1 DEFECTIVE F8 SULFATION AT Y1699%REACTOME%R-HSA-9674519.1 Defective F8 sulfation at Y1699 F8 TPST2 TPST1 SUMOYLATION OF DNA METHYLATION PROTEINS%REACTOME DATABASE ID RELEASE 76%4655427 SUMOylation of DNA methylation proteins CBX8 CBX4 CBX2 PHC2 PHC1 RING1 BMI1 SUMO1 RNF2 DNMT1 PHC3 DNMT3B PCGF2 UBE2I INHIBITION OF HOST MRNA PROCESSING AND RNA SILENCING%REACTOME DATABASE ID RELEASE 76%168315 Inhibition of Host mRNA Processing and RNA Silencing PABPN1 NS CPSF4 ANCHORING OF THE BASAL BODY TO THE PLASMA MEMBRANE%REACTOME DATABASE ID RELEASE 76%5620912 Anchoring of the basal body to the plasma membrane B9D2 RPGRIP1L RAB3IP MKS1 HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 CEP97 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 RAB11A DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 NPHP4 HAUS7 PRKAR2B CEP70 CEP72 CEP192 C2CD3 TCTN3 PCNT TCTN2 CEP76 TCTN1 CLASP1 CC2D2A CEP78 IQCB1 PLK4 KIF24 DYNC1H1 TMEM216 ODF2 FBF1 CEP152 TTBK2 NDE1 TMEM67 PLK1 NPHP1 TUBB4B MARK4 TUBB4A SEPTIN2 NEDD1 SCLT1 CENPJ AHI1 ALMS1 CDK1 CEP83 CEP162 CEP41 B9D1 CEP43 CEP89 SIGNALING BY FGFR2%REACTOME%R-HSA-5654738.2 Signaling by FGFR2 BRAF GAB1 PIK3CA PLCG1 FRS3 SOS1 POLR2A POLR2B POLR2C MAPK1 POLR2D POLR2E POLR2F POLR2G POLR2H MAPK3 POLR2I POLR2J POLR2K PPP2CA POLR2L PPP2CB GTF2F1 GTF2F2 PTPN11 PTBP1 PPP2R1A PIK3R1 ESRP1 CBL HNRNPA1 TIAL1 TIA1 RBFOX2 ESRP2 MKNK1 FGFBP1 SPRY2 FGFBP2 FGFBP3 UBA52 NCBP1 NCBP2 UBB HRAS UBC HNRNPM FGF1 RPS27A HNRNPF FGF2 FGF3 FGF4 FGF6 NRAS FGF7 FGF9 FGF20 HNRNPH1 FGF23 FGF22 FRS2 FGF16 FGF18 FGF10 DEFECTIVE SLC35D1 CAUSES SCHBCKD%REACTOME%R-HSA-5579020.2 Defective SLC35D1 causes SCHBCKD SLC35D1 INTERLEUKIN-18 SIGNALING%REACTOME%R-HSA-9012546.2 Interleukin-18 signaling ALOX5 IL4 IL37 IL18 IL18BP IL13 IL18R1 IL18RAP NTRK2 ACTIVATES RAC1%REACTOME%R-HSA-9032759.1 NTRK2 activates RAC1 RAC1 BDNF DOCK3 NTRK2 TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT%REACTOME DATABASE ID RELEASE 76%159231 Transport of Mature mRNA Derived from an Intronless Transcript FIP1L1 NUP42 NUP210 NUP43 RAE1 CPSF1 RANBP2 NUP93 CPSF4 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 EIF4E CPSF3 NCBP1 CPSF2 NUP214 NUP153 NCBP2 SYMPK NXF1 SEC13 WDR33 NUP62 NDC1 ALYREF NUP133 NUP107 NUP188 NUP50 NUP54 DOWNSTREAM SIGNALING OF ACTIVATED FGFR3%REACTOME%R-HSA-5654708.1 Downstream signaling of activated FGFR3 HRAS GAB1 FGF1 FGF2 PIK3CA PLCG1 FRS3 FGF4 SOS1 NRAS PTPN11 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF18 CD22 MEDIATED BCR REGULATION%REACTOME DATABASE ID RELEASE 76%5690714 CD22 mediated BCR regulation IGHV3-53 IGLC7 IGKV2D-40 IGHV3-11 IGKV5-2 IGLC6 IGHV3-13 IGHV1-46 IGHV IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 IGKV1-5 IGLV PTPN6 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 CD79B IGLV1-44 CD79A IGKV3-15 IGKV3-11 CD22 IGHM IGHD IGLV7-43 IGKV1D-16 IGKV1D-12 LYN IGHV3-23 IGLV1-51 IGLV2-23 IGLV2-8 IGKV3-20 IGHV4-34 IGKV1-16 IGHV1-2 IGHV4-39 IGKV1-17 IGKV1-12 IGHV3-7 IGKV2-29 IGHV3-9 IGKV2-28 IGLC3 IGHV3-30 IGLC1 IGLC2 IGHV3-33 IGKV2D-28 IGKV4-1 IGHV7-81 IGKV3D-20 IGKV2D-30 IGKV2-30 IGHV2-70 IGHV2-5 IGHV1-69 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 ACTIVATED NTRK2 SIGNALS THROUGH CDK5%REACTOME%R-HSA-9032845.1 Activated NTRK2 signals through CDK5 CDK5 RAC1 BDNF TIAM1 CDK5R1 NTRK2 SIGNALING BY GSK3BETA MUTANTS%REACTOME%R-HSA-5339716.3 Signaling by GSK3beta mutants PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 HYALURONAN UPTAKE AND DEGRADATION%REACTOME%R-HSA-2160916.3 Hyaluronan uptake and degradation CHP1 HMMR CD44 GUSB HEXB SLC9A1 HYAL1 HEXA STAB2 HYAL3 LYVE1 HYAL2 MOLYBDENUM COFACTOR BIOSYNTHESIS%REACTOME%R-HSA-947581.1 Molybdenum cofactor biosynthesis MOCOS MOCS2 MOCS3 GPHN PYROPHOSPHATE HYDROLYSIS%REACTOME%R-HSA-71737.2 Pyrophosphate hydrolysis PPA2 PPA1 METABOLIC DISORDERS OF BIOLOGICAL OXIDATION ENZYMES%REACTOME%R-HSA-5579029.3 Metabolic disorders of biological oxidation enzymes TPMT CYP17A1 UGT1A4 CYP4F22 AHCY CYP19A1 CYP11A1 MAOA ACY1 GCLC CYP11B2 CYP21A2 TBXAS1 GCLM OPLAH CYP27B1 CYP11B1 CYP26B1 CYP24A1 CYP26C1 CYP2R1 FMO3 CYP7B1 UGT1A1 FDXR CYP27A1 CYP1B1 GSS SLC35D1 GGT1 CYP2U1 MAT1A FDX1 FDX2 OXIDATIVE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559580.4 Oxidative Stress Induced Senescence TP53 CBX8 CBX6 CBX4 CDKN2A CBX2 MDM2 MINK1 MDM4 BMI1 MAP2K6 MAP4K4 IFNB1 FOS AGO3 AGO4 AGO1 MAPK1 MAPK3 H2AX H2AB1 H2AC19 KDM6B H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 RNF2 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 MAPK8 H3C15 RBBP4 PHC2 PHC1 RING1 H2BS1 RBBP7 H2AZ1 H2BC9 UBA52 H2AZ2 EZH2 H4C9 PHC3 H2BC8 H2BC5 H2BC3 EED H2BC1 H2AC20 MAP2K3 MAP2K4 UBB MAPKAPK3 SUZ12 TFDP1 MAP2K7 MAPKAPK2 UBC JUN CDK6 TFDP2 RPS27A MAPK9 CDK4 E2F1 E2F2 MAPK10 E2F3 CDKN2D CDKN2C TNRC6C MOV10 MAP3K5 TNIK TNRC6A TNRC6B MAPK14 MAPK11 CDKN2B TXN MAPKAPK5 PACKAGING OF TELOMERE ENDS%REACTOME%R-HSA-171306.3 Packaging Of Telomere Ends H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 LATENT INFECTION - OTHER RESPONSES OF MTB TO PHAGOCYTOSIS%REACTOME DATABASE ID RELEASE 76%1222499 Latent infection - Other responses of Mtb to phagocytosis Rv1281c msrA irtB lpdC irtA sodC sodB ahpE ahpD ahpC katG secY secF secE Rv1280c secA1 secG secD secA2 Rv2895c MT2748 bfr dlaT mscR Rv1283c trx-2 Rv1282c glbN fgd1 ggt-1 trxA bfrB tpx trxB LTF CDC20:PHOSPHO-APC C MEDIATED DEGRADATION OF CYCLIN A%REACTOME%R-HSA-174184.2 Cdc20:Phospho-APC C mediated degradation of Cyclin A CCNA1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDK1 CCNA2 SIGNALING BY PTK6%REACTOME DATABASE ID RELEASE 76%8848021 Signaling by PTK6 CCNE1 NR3C1 DOCK1 CDK2 ELMO2 ARHGAP35 ERBB2 SFPQ CBL LRRK2 PELP1 NRG1 NRG2 NRG3 NRG4 ELMO1 CRK KHDRBS1 KHDRBS2 KHDRBS3 EPAS1 PXN EGF HIF1A SOCS3 GPNMB STAP2 PTPN1 SRMS UBA52 HBEGF BCAR1 STAT3 EGFR AKT1 UBB HRAS UBC RASA1 CCND1 RPS27A CDK4 NRAS DOK1 PTK6 RAC1 ARAP1 EREG RHOA BTC CDKN1B POU5F1 (OCT4), SOX2, NANOG ACTIVATE GENES RELATED TO PROLIFERATION%REACTOME%R-HSA-2892247.3 POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation ZIC3 DPPA4 SOX2 STAT3 NANOG FGF2 TDGF1 SALL1 SALL4 POU5F1 FOXD3 EPHA1 VARIANT SLC6A20 CONTRIBUTES TOWARDS HYPERGLYCINURIA (HG) AND IMINOGLYCINURIA (IG)%REACTOME%R-HSA-5660686.1 Variant SLC6A20 contributes towards hyperglycinuria (HG) and iminoglycinuria (IG) SLC6A20 INTERLEUKIN-36 PATHWAY%REACTOME%R-HSA-9014826.1 Interleukin-36 pathway IL1RL2 IL36RN IL36A IL36B IL1F10 IL36G ACTIVATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME DATABASE ID RELEASE 76%2485179 Activation of the phototransduction cascade GNGT1 CNGA1 SAG GNB1 PDE6B PDE6A PDE6G RHO SLC24A1 CNGB1 GNAT1 INTEGRATION OF ENERGY METABOLISM%REACTOME DATABASE ID RELEASE 76%163685 Integration of energy metabolism PLCB3 PLCB1 PPP2R1B PLCB2 KCNJ11 PPP2R5D STXBP1 CACNA2D2 ITPR1 ITPR2 GNG10 ITPR3 PPP2CA GNG12 PPP2CB GNG11 GNAI1 GNG13 GNAI2 GNB2 GNAQ PRKAB2 GNB1 PRKAA2 GNB4 STX1A GNB3 PRKAG2 GNB5 PPP2R1A ADRA2C GCG GNGT1 IQGAP1 ADRA2A PRKACA GNGT2 SYT5 INS CACNA1A CACNA1E GNA14 MLXIPL GNG3 ADIPOQ GNA15 ADIPOR1 ACSL3 ADIPOR2 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 CACNB2 ACLY CACNB3 PRKCA GLP1R PRKAR2B SNAP25 FFAR1 ACACB PRKACG PRKACB ADCY9 PRKAR1B KCNG2 PRKAR1A CD36 PRKAR2A GNAS MLX AGPAT1 ADCY4 AKAP5 ADCY3 ADCY2 ADCY1 KCNC2 ADCY8 ADCY7 ADCY6 ADCY5 TALDO1 FASN CACNA1D CACNA1C TKT PFKFB1 CHRM3 KCNB1 VAMP2 KCNS3 CYSLTR2 STK11 AHCYL1 ACACA SLC2A1 SLC2A2 RAP1A RAPGEF3 RAPGEF4 MARCKS ABCC8 NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9675108.2 Nervous system development EPHB6 MYL12A EFNB2 EFNB1 SDCBP EFNB3 FYN PAK3 EPHB2 MAPK1 EPHB1 EPHB4 EPHB3 EZR MAPK3 HSP90AA1 ERBB2 RDX MSN MYO9B ALCAM PRKACA DPYSL4 DPYSL5 RPL4 SCN11A RPL5 DPYSL2 RPL30 DPYSL3 RPL3 HOXA2 RPL32 UNC5A RPL31 UNC5B RPL34 UNC5C UNC5D RPLP1 ISL1 RPL10L MYL6 RPLP0 SCN10A RPL10A RPL8 MYL9 ABL1 RPL6 AGAP2 RPL7 FLRT3 UPF3A RPS4X L1CAM RPS15 RET RPL7A CHL1 RPS14 UPF2 RPS17 LYPLA2 RPS16 DSCAML1 RPL18A ZSWIM8 RPS19 FARP2 RPS18 SEMA5A RPL36AL RPL36 PLXND1 CDK5 RPL35 ITGA2B KIF4B RPLP2 MSI1 RPL38 UBA52 PLXNC1 KIF4A RPL37 MAP2K1 SEMA6A RPS11 RPL39 MAP2K2 SEMA6D RPS10 CACNB1 RPS13 CACNB2 RPS12 CACNB3 RPS9 CACNB4 RPS7 SEMA7A RPL21 SHC3 PLXNA2 NCBP1 RPS8 PLXNA1 SRGAP3 NCBP2 RPS5 SRGAP1 UBB RPL23 PLXNA4 RPL22 PLXNA3 RPS6 PTPRC DAB1 RPL13A UBC RPSA LHX3 PTPRA RPS3A RPS27A LHX2 RPL9P9 ITGA10 RPL37A RPL24 PLXNB3 RPL27 LHX4 CLASP1 LHX9 ETF1 RPL26 CNTNAP1 RPL29 ITGB3 RPL28 PIK3CD RPS4Y2 TREM2 RPL10 ITGAV RAC1 RPL12 NEO1 RPL11 ITGA2 ITGA1 RPL36A RPS27L EVL RPS4Y1 ITGA5 MET GSPT2 ITGA9 GSPT1 RPS15A SEMA3A RPL14 NTN4 RPS3 SEMA3E RPL13 ABLIM1 RPS2 ABLIM2 RPL15 ABLIM3 RPL18 SEMA4A RPL17 SEMA4D RPL19 NELL2 NFASC RPL39L RPL41 RPS6KA4 MYO10 RPL35A DAG1 RPL23A SCN1B RPL3L SCN1A DOCK1 ELOB EPHA5 RPS26 ELOC EPHA4 RPS25 EPHA7 RPS28 EPHA6 RPS27 EPHA8 RPS29 SHTN1 RPL27A RPL22L1 KCNQ2 KCNQ3 RPS20 EPHA1 FAU TLN1 RPS21 PFN1 RPL26L1 EPHA3 RPS24 PFN2 RPS23 GRB7 EPHA10 GRIN2B MYL12B RPS6KA6 RRAS GRIN1 SCN3B SCN3A DLG1 VASP SIAH1 DLG3 ARTN CD24 DLG4 SCN2A SCN2B ROBO2 NRP1 ROBO1 CAP1 ACTB GFRA1 GFRA3 RGMB GFRA2 GFRA4 RGMA ENAH AKAP5 RELN PAK5 CAP2 CLTA CD72 AP2A1 RANBP9 SCN9A VLDLR NRTN DSCAM AP2A2 DOK2 TYROBP DOK4 DOK5 DOK6 SCN8A CACNA1D AP2M1 CACNA1C EFNA5 EFNA4 PSMD8 CACNA1H PSMD9 CACNA1G PSMD6 CACNA1I PSMD7 HDAC2 MYH14 PSMD4 MYH11 CACNA1S PSMD5 MYH10 PSMD2 PRNP PSMD3 PSPN PSMD1 CNTN6 PSMA5 EFNA1 PSMA6 EFNA3 EFNA2 PSMA3 GDNF PSMA4 FES PSMA1 CNTN1 PSMA2 LDB1 PSME3 RND1 PSME4 HJV PSME1 SCN5A PSME2 GAP43 PSMD10 DCX SCN4A PSMB11 PSMD12 SHANK3 AP2S1 PSMD11 SCN4B PSMD14 LAMA1 PSMD13 CRMP1 SLIT1 PSMA7 SCN7A PSMB10 SLIT3 PSMA8 NCAM1 PSMB6 SLIT2 PSMB7 PDLIM7 PSMB4 CLASP2 PSMB5 MAPK12 PSMB2 AP2B1 MAPK13 PSMB3 PSMB1 PSMF1 PAK2 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 RAP1GAP PSMC2 CSNK2A1 CSNK2A2 VAV3 CSNK2B KALRN HSP90AB1 ARHGEF28 ARPC1B ACTG1 CFL1 LYN YES1 LIMK2 LIMK1 PTK2 SDC2 ITSN1 GPC1 SHC1 GAB1 PIK3CA PLCG1 TRPC5 SOS1 TRPC4 TRPC1 AGRN PIP5K1C CXCR4 ST8SIA4 ARPC1A CLTB ST8SIA2 EGFR CLTCL1 COL4A2 SMARCA4 COL4A1 COL4A4 COL6A2 COL4A3 COL6A1 CXCL12 COL4A5 COL6A3 COL6A6 COL6A5 ITGB1 TRIO ARPC4 ARPC5 RPS6KA3 RPS6KA5 RPS6KA2 ARHGAP39 ARPC2 RPS6KA1 ARPC3 ARHGAP35 ACTR2 VAV2 TIAM1 SPTB GRB10 PIK3R2 ABL2 SRGAP2 PAK4 TEAD1 ADAM10 ANK2 ANK3 ANK1 YAP1 SRC PSEN1 WWTR1 SPTBN4 NCSTN SPTBN5 COL9A1 COL9A3 COL9A2 EIF4A3 SPTBN2 CASC3 LAMC1 MAGOH SH3KBP1 MAG NGEF MMP2 RBM8A MMP9 PSEN2 APH1A APH1B UPF3B MAGOHB RNPS1 DCC PITPNA NTN1 PSENEN NAB1 ARHGEF11 LAMB1 NAB2 UTRN ARHGEF12 MBP ADGRV1 EGR2 MPZ SOS2 POU3F1 POU3F2 ADGRG6 LAMA2 HMGCR SOX10 SH3GL2 IRS2 PIK3CB PRX DRP2 FRS2 GAB2 SCD5 SPTA1 PMP22 TRPC7 TRPC6 TRPC3 SIAH2 DNM1 DNM2 DNM3 HSPA8 PTPN11 MYH9 CLTC WASL PIK3R1 CDC42 PAK1 NCK2 PAK6 MAPK8 SPTAN1 GIT1 CDK5R1 SPTBN1 NCK1 CUL2 USP33 ARHGEF7 EPHA2 GSK3B PRKCA MAPK7 PABPC1 CREB1 MAPK14 MAPK11 PRKCQ EIF4G1 CYP51A1 PRKACG PRKACB SREBF2 RBX1 RHOC RHOB PLXNB1 PRKAR2A NUMB NRP2 CNTN2 NRCAM NCAN ROCK1 ROCK2 HRAS RASA1 NRAS DOK1 PIK3R3 RHOA PPP3CB FGFRL1 MODULATION OF FGFR1 SIGNALING%REACTOME%R-HSA-5658623.3 FGFRL1 modulation of FGFR1 signaling SPRED2 FGF23 SPRED1 FGF22 FGF18 FGF2 FGF3 FGF4 FGFRL1 FGF10 INTERLEUKIN-6 FAMILY SIGNALING%REACTOME%R-HSA-6783589.6 Interleukin-6 family signaling STAT1 LIF IL11 OSMR IL31 IL6ST OSM PTPN11 TYK2 SOCS3 IL11RA CRLF1 CNTFR CNTF JAK2 IL31RA CTF1 STAT3 IL6R CLCF1 CBL JAK1 IL6 LIFR RESOLUTION OF AP SITES VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME DATABASE ID RELEASE 76%110381 Resolution of AP sites via the single-nucleotide replacement pathway LIG3 XRCC1 APEX1 POLB GLI3 IS PROCESSED TO GLI3R BY THE PROTEASOME%REACTOME%R-HSA-5610785.1 GLI3 is processed to GLI3R by the proteasome PRKACG PRKACB RBX1 GLI3 SUFU BTRC CSNK1A1 PRKACA SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 GSK3B PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TP53 REGULATES TRANSCRIPTION OF ADDITIONAL CELL CYCLE GENES WHOSE EXACT ROLE IN THE P53 PATHWAY REMAIN UNCERTAIN%REACTOME DATABASE ID RELEASE 76%6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CNOT8 PLK2 CDC25C CNOT9 TP53 BTG2 TNKS1BP1 CNOT6L PLK3 CNOT10 PLAGL1 CNOT4 CNOT6 CENPJ RGCC NPM1 CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 REELIN SIGNALLING PATHWAY%REACTOME%R-HSA-8866376.2 Reelin signalling pathway SH3KBP1 VLDLR DAB1 FYN RELN FORMATION OF EDITOSOMES BY ADAR PROTEINS%REACTOME DATABASE ID RELEASE 76%77042 Formation of editosomes by ADAR proteins ADAR ADARB1 LINOLEIC ACID (LA) METABOLISM%REACTOME%R-HSA-2046105.1 Linoleic acid (LA) metabolism ABCD1 ELOVL1 FADS2 ELOVL5 ACSL1 ELOVL2 ELOVL3 FADS1 RNA POLYMERASE II TRANSCRIBES SNRNA GENES%REACTOME%R-HSA-6807505.2 RNA polymerase II transcribes snRNA genes ELL RPRD1B INTS4 CCNT1 RPRD1A INTS7 SUPT4H1 INTS6 INTS9 POU2F1 INTS8 INTS11 INTS12 INTS13 INTS14 POU2F2 INTS10 SNAPC5 GTF2A1 SNAPC1 GTF2A2 GTF2B SNAPC2 SP1 SNAPC3 TAF9 SNAPC4 CDK9 GTF2E1 GTF2E2 POLR2A POLR2B POLR2C ICE1 POLR2D ICE2 POLR2E TAF13 POLR2F POLR2G TAF11 SSU72 POLR2H CCNT2 POLR2I POLR2J TAF6 POLR2K TAF5 POLR2L SUPT5H GTF2F1 NABP2 NABP1 GTF2F2 CDK7 TBP TAF8 PHAX ZC3H8 ZNF143 ELL2 ELL3 NCBP1 NCBP2 RPRD2 PCF11 RPAP2 CCNK SRRT INTS1 INTS3 INTS2 INTS5 JNK (C-JUN KINASES) PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1%REACTOME DATABASE ID RELEASE 76%450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TAB1 MAP2K4 UBE2V1 MAP2K7 MAPK9 IKBKG MAPK10 NOD1 NOD2 IRAK1 IRAK2 RIPK2 MAPK8 TRAF6 UBE2N TAB3 TAB2 MAP3K7 GRB2:SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTEGRINS%REACTOME%R-HSA-354194.1 GRB2:SOS provides linkage to MAPK signaling for Integrins PTK2 FN1 FGB FGA VWF SOS1 ITGB3 FGG RAP1B RAP1A TLN1 ITGA2B APBB1IP SRC DEFECTIVE C1GALT1C1 CAUSES TN POLYAGGLUTINATION SYNDROME (TNPS)%REACTOME DATABASE ID RELEASE 76%5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) MUC4 MUC6 MUC12 MUC15 MUC3A MUC3B MUC16 MUC17 MUC19 MUC20 MUC21 MUCL1 MUC5B MUC5AC C1GALT1C1 MUC1 C1GALT1 MUC2 MUC13 MUC7 CALMODULIN INDUCED EVENTS%REACTOME%R-HSA-111933.1 Calmodulin induced events PRKCG KPNA2 PRKACG PRKACB ADCY9 CAMKK1 PRKAR1B CAMKK2 PRKAR1A PDE1B PDE1A PRKAR2A PRKX PRKCD PRKCA CAMK2B PRKAR2B CAMK2D NBEA CAMK2A PDE1C CAMK2G ADCY4 ADCY3 ADCY2 ADCY1 CREB1 ADCY8 ADCY7 CAMK4 ADCY6 ADCY5 PRKACA GRK2 CALM1 DEFECTIVE ABCC9 CAUSES CMD10, ATFB12 AND CANTU SYNDROME%REACTOME%R-HSA-5678420.2 Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome ABCC9 KCNJ11 TGFBR2 KINASE DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%3645790 TGFBR2 Kinase Domain Mutants in Cancer TGFB1 TGFBR1 TGFBR2 RECYCLING OF EIF2:GDP%REACTOME DATABASE ID RELEASE 76%72731 Recycling of eIF2:GDP EIF2S2 EIF2S1 EIF2S3 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 INTERFERON GAMMA SIGNALING%REACTOME%R-HSA-877300.3 Interferon gamma signaling MT2A OAS1 FCGR1A IRF4 IRF1 OAS2 IRF2 OAS3 IRF8 IRF5 IRF6 PIAS1 IRF9 TRIM46 SUMO1 B2M TRIM48 HLA-A GBP2 FCGR1B GBP1 GBP4 GBP3 TRIM45 TRIM35 TRIM38 TRIM31 TRIM34 PTAFR PTPN11 CD44 IRF3 SOCS1 IFNG PTPN6 IFNGR1 IFNGR2 JAK1 TRIM21 IRF7 IFI30 SOCS3 ICAM1 PTPN1 TRIM29 TRIM26 TRIM22 GBP6 GBP5 TRIM17 TRIM14 HLA-H TRIM10 NCAM1 HLA-B SP100 HLA-DQA2 PML HLA-C HLA-DQA1 HLA-F HLA-G HLA-DRB5 PRKCD HLA-E HLA-DRB4 CAMK2B HLA-DRB3 CAMK2D HLA-DRB1 TRIM8 TRIM6 CAMK2A TRIM5 TRIM2 TRIM25 TRIM3 CAMK2G HLA-DPA1 HLA-DQB2 HLA-DQB1 HLA-DPB1 JAK2 MID1 VCAM1 HLA-DRA CIITA OASL TRIM68 TRIM62 DEFECTIVE NTHL1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 76%9630221 Defective NTHL1 substrate processing NTHL1 DEFECTIVE SLC29A3 CAUSES HISTIOCYTOSIS-LYMPHADENOPATHY PLUS SYNDROME (HLAS)%REACTOME DATABASE ID RELEASE 76%5619063 Defective SLC29A3 causes histiocytosis-lymphadenopathy plus syndrome (HLAS) SLC29A3 MATURATION OF SPIKE PROTEIN%REACTOME%R-HSA-9683686.2 Maturation of spike protein MGAT1 PRKCSH MOGS GANAB S CANX ACTIVATED PKN1 STIMULATES TRANSCRIPTION OF AR (ANDROGEN RECEPTOR) REGULATED GENES KLK2 AND KLK3%REACTOME DATABASE ID RELEASE 76%5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 H3C15 AR H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 KDM1A H2AC14 NCOA2 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 KLK3 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 KDM4C H2BC11 PKN1 KLK2 REGORAFENIB-RESISTANT PDGFR MUTANTS%REACTOME%R-HSA-9674403.1 Regorafenib-resistant PDGFR mutants PDGFRA REGULATION BY TREX1%REACTOME DATABASE ID RELEASE 76%3248023 Regulation by TREX1 TREX1 SODIUM-COUPLED PHOSPHATE COTRANSPORTERS%REACTOME%R-HSA-427652.1 Sodium-coupled phosphate cotransporters SLC34A3 SLC20A1 SLC34A2 SLC34A1 SLC20A2 WAX AND PLASMALOGEN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%8848584 Wax and plasmalogen biosynthesis GNPAT FAR1 FAR2 AWAT2 AWAT1 DHRS7B AGPS DEFECTIVE FACTOR VIII CAUSES HEMOPHILIA A%REACTOME%R-HSA-9662001.1 Defective factor VIII causes hemophilia A F2 F9 F8 F10 VWF TPST2 TPST1 ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION%REACTOME%R-HSA-450302.2 activated TAK1 mediates p38 MAPK activation MAP2K3 TAB1 UBE2V1 MAPKAPK3 MAPKAPK2 IKBKG MAP2K6 NOD1 NOD2 MAPK14 MAPK11 IRAK1 IRAK2 RIPK2 TRAF6 UBE2N TAB3 TAB2 MAP3K7 MECP2 REGULATES TRANSCRIPTION OF NEURONAL LIGANDS%REACTOME DATABASE ID RELEASE 76%9022702 MECP2 regulates transcription of neuronal ligands HDAC1 BDNF CRH SST DLL1 SIN3A CREB1 THE ACTIVATION OF ARYLSULFATASES%REACTOME%R-HSA-1663150.1 The activation of arylsulfatases ARSA ARSF ARSG SUMF2 SUMF1 ARSD ARSB STS ARSL ARSJ ARSK ARSH ARSI ABERRANT REGULATION OF MITOTIC EXIT IN CANCER DUE TO RB1 DEFECTS%REACTOME DATABASE ID RELEASE 76%9687136 Aberrant regulation of mitotic exit in cancer due to RB1 defects RB1 FZR1 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 SKP2 ANAPC1 TRANS-GOLGI NETWORK VESICLE BUDDING%REACTOME DATABASE ID RELEASE 76%199992 trans-Golgi Network Vesicle Budding AP1S2 AP1M2 AP1S1 AP1M1 TXNDC5 AP1S3 TGOLN2 SNX2 AP4B1 SNX9 SNX5 IGF2R GNS TBC1D8B M6PR CHMP2A TFRC ACBD3 APP BLOC1S4 BLOC1S6 SNAP23 BLOC1S1 BLOC1S3 PUM1 SNAPIN DNM2 ARRB1 CTSZ PIK3C2A AP4E1 AP4M1 HSPA8 HGS AP1G2 AP1G1 ARF1 SH3D19 CLTA OCRL CLTC DNASE2 CLTB AP3B1 GAK CLINT1 AP3S1 NAPA DNAJC6 VAMP8 CLVS2 VAMP7 SORT1 GBF1 CLVS1 DTNBP1 VAMP2 HIP1R TPD52L1 YIPF6 NECAP1 STX4 SH3GL2 FTH1 TPD52 CPD PICALM AP1B1 FTL RAB5C AP4S1 SMAC(DIABLO)-MEDIATED DISSOCIATION OF IAP:CASPASE COMPLEXES%REACTOME DATABASE ID RELEASE 76%111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes XIAP CASP9 APAF1 CASP7 CASP3 DIABLO CYCS AGMATINE BIOSYNTHESIS%REACTOME%R-HSA-351143.1 Agmatine biosynthesis AZIN2 AGMAT SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE%REACTOME DATABASE ID RELEASE 76%1660514 Synthesis of PIPs at the Golgi membrane PIK3C2A PI4KB PIK3R4 PIK3C2G TPTE ARF3 ARF1 OCRL PI4K2B VAC14 INPP5E SACM1L PI4KA FIG4 PIKFYVE TPTE2 PIK3C3 PI4K2A REGULATION OF INSULIN SECRETION%REACTOME%R-HSA-422356.4 Regulation of insulin secretion PLCB3 PLCB1 PLCB2 PRKACG KCNJ11 PRKACB PRKAR1B KCNG2 PRKAR1A STXBP1 CD36 CACNA2D2 PRKAR2A ITPR1 ITPR2 GNG10 ITPR3 GNAS GNG12 GNAI1 GNG11 GNAI2 GNG13 GNB2 GNAQ GNB1 GNB4 STX1A AKAP5 GNB3 GNB5 KCNC2 ADRA2C ADCY8 GCG GNGT1 ADCY6 IQGAP1 ADCY5 ADRA2A GNGT2 PRKACA CACNA1D CACNA1C INS SYT5 CACNA1A CACNA1E GNA14 GNG3 GNA15 CHRM3 ACSL3 GNG2 KCNB1 GNG5 GNG4 VAMP2 GNG7 GNA11 GNG8 KCNS3 CACNB2 CACNB3 AHCYL1 GLP1R PRKCA PRKAR2B SNAP25 SLC2A1 SLC2A2 RAP1A FFAR1 RAPGEF3 RAPGEF4 MARCKS ABCC8 ACYL CHAIN REMODELLING OF PS%REACTOME%R-HSA-1482801.3 Acyl chain remodelling of PS OSBPL5 OSBPL10 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G4D PLA2G2E PLA2G4E MBOAT1 PLA2G4B PLAAT3 PLA2G4A LPCAT4 PLA2G10 PLA2G2A PLA2R1 PLA1A LPCAT3 PLA2G1B OSBPL8 PLA2G5 SIGNALING BY MAPK MUTANTS%REACTOME DATABASE ID RELEASE 76%9652817 Signaling by MAPK mutants DUSP10 DUSP9 DUSP6 DUSP7 MAPK1 DUSP16 DUSP8 DEFECTIVE MTRR CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLE%REACTOME%R-HSA-3359467.1 Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE MTRR MTR DEFECTIVE CYP21A2 CAUSES AH3%REACTOME%R-HSA-5579021.2 Defective CYP21A2 causes AH3 CYP21A2 BIOSYNTHESIS OF THE N-GLYCAN PRECURSOR (DOLICHOL LIPID-LINKED OLIGOSACCHARIDE, LLO) AND TRANSFER TO A NASCENT PROTEIN%REACTOME%R-HSA-446193.1 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein ST3GAL3 ST6GALNAC1 CMAS RFT1 MPI GMPPB NANP FPGT GMPPA PGM3 GNPNAT1 ST6GALNAC2 GFUS NANS NUDT14 ST6GAL2 ALG5 RENBP DPM1 ALG10 DPM2 DPM3 MVD ST6GALNAC5 GNE ST3GAL4 ST6GALNAC6 UAP1 NPL ST3GAL1 FUOM ST3GAL2 ST6GAL1 NEU2 NEU3 NEU4 GMDS AMDHD2 NEU1 ST8SIA4 ST3GAL5 ST8SIA5 ST8SIA6 ST3GAL6 ST6GALNAC3 CTSA ST6GALNAC4 PMM1 ST8SIA1 ST8SIA2 GFPT2 GFPT1 PMM2 ST8SIA3 ALG8 SRD5A3 ALG9 DOLK ALG6 NUS1 NAGK ALG3 DHDDS FCSK ALG1 GLB1 DOLPP1 SLC35A1 DPAGT1 SLC35C1 ALG10B MPDU1 ALG2 ALG14 SLC17A5 ALG13 ALG12 ALG11 GAP JUNCTION TRAFFICKING%REACTOME DATABASE ID RELEASE 76%190828 Gap junction trafficking GJA4 GJA9 GJD2 GJA8 GJD4 GJD3 GJA10 GJC1 GJC2 MYO6 DAB2 DNM1 DNM2 GJB2 GJB1 GJB4 GJB3 GJB6 GJB5 GJB7 CLTA CLTC CLTB GJA1 CLTCL1 AP2M1 GJA3 GJA5 VISUAL PHOTOTRANSDUCTION%REACTOME%R-HSA-2187338.1 Visual phototransduction PDE6B PDE6A NMT2 PDE6G NAPEPLD GNAT1 CNGA1 MYO7A SAG RDH12 SLC24A1 LRP8 APOB ABCA4 GNB1 GNGT1 RLBP1 RCVRN CALM1 METAP1 METAP2 LRP2 DHRS3 DHRS9 RDH10 RDH16 RDH5 OPN1SW PRKCA OPN1LW AWAT2 CNGB1 CYP4V2 HSPG2 SDC4 PRKCQ SDC2 SDC3 RPE65 GPC1 GPC3 GPC2 GPC5 GPC4 GPC6 RDH8 OPN1MW SDC1 AGRN RBP3 HSD17B1 LRP1 RETSAT PLB1 GUCY2D TTR APOM HSD17B6 RDH11 GUCY2F LRAT BCO2 AKR1C1 BCO1 RHO RBP4 CLPS AKR1C3 AKR1B10 RBP2 RBP1 AKR1C4 LRP10 PNLIP LRP12 CAMKMT SDR9C7 APOA2 APOA1 APOA4 RGS9BP LPL APOE LDLR GPIHBP1 APOC3 GRK1 GUCA1B FNTB GUCA1A GRK7 GUCA1C APOC2 STRA6 NMT1 FNTA PPEF1 KW2449-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702569 KW2449-resistant FLT3 mutants FLT3 ACTIVATION OF CA-PERMEABLE KAINATE RECEPTOR%REACTOME%R-HSA-451308.2 Activation of Ca-permeable Kainate Receptor GRIK4 GRIK1 GRIK2 GRIK3 DLG1 CALM1 NCALD DLG3 DLG4 GRIK5 CREB1 PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII CAMKK CAMKIV CASCASDE%REACTOME%R-HSA-442729.3 CREB1 phosphorylation through the activation of CaMKII CaMKK CaMKIV cascasde CAMK4 CAMK2B CAMKK1 CAMKK2 KPNA2 CALM1 CAMK2G CREB1 G ALPHA (S) SIGNALLING EVENTS%REACTOME%R-HSA-418555.9 G alpha (s) signalling events GPR15 GPR27 GPR25 RLN2 GPR20 RLN3 ADM PTH1R GPR32 PDE3A PTH2R HTR4 PDE1B PDE1A RXFP1 PDE8B RAMP2 RXFP2 GNG10 RAMP3 PDE8A GPR45 PTH HTR6 GRK5 GNAI3 GRK6 HTR7 GNG12 ARRB1 GNG11 ARRB2 GNAI1 PDE11A GNG13 GNAI2 PDE4A GNB2 INSL3 PTGDR PDE4D GNB1 PDE4C TSHB TAAR8 PDE2A GNB4 PTGIR GPR150 TAAR9 TAAR6 GNB3 AVPR2 TAAR5 TAAR2 GNB5 SCTR GCG TAAR1 GHRH GNGT1 ADM2 PDE7B RAMP1 PDE7A GNGT2 PDE10A ADORA2A LHB ADORA2B ADCYAP1 ADCYAP1R1 IAPP MC2R GNAZ CALCA CALCB CALCRL GNG3 GPR83 GPR84 GNG2 CGA CALCR GNG5 GNG4 GNG7 GNG8 TSHR MC1R POMC GLP1R MC4R GLP2R GIP CRH GPR39 PTH2 SRC PTHLH FSHB GPBAR1 MC3R ADRB3 VIP FSHR AVP PTGER4 NPSR1 ADCY9 PTGER2 GNAS NPS ADCY4 ADCY3 ADCY2 ADCY1 GPHA2 ADCY8 ADCY7 ADCY6 ADCY5 P2RY11 MC5R GPHB5 CYSLTR2 VIPR1 VIPR2 LHCGR SCT GPR176 GNAT3 PDE3B ADRB1 ADRB2 TAAR3P HRH2 GIPR DRD1 GRK3 GRK2 CRHR1 CRHR2 DRD5 GHRHR ACTIVATION OF APC C AND APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME%R-HSA-176814.3 Activation of APC C and APC C:Cdc20 mediated degradation of mitotic proteins CCNA1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CCNB1 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PTTG1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 CDK1 CCNA2 LOSS OF NLP FROM MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 76%380259 Loss of Nlp from mitotic centrosomes HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 SARS-COV-1 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9679514.2 SARS-CoV-1 Genome Replication and Transcription GSK3B RB1 ZCRB1 DDX5 VHL N GSK3A 1a rep RSK ACTIVATION%REACTOME%R-HSA-444257.3 RSK activation RPS6KA6 MAPK1 RPS6KA3 PDPK1 RPS6KA2 RPS6KA1 MAPK3 TALDO1 DEFICIENCY: FAILED CONVERSION OF SH7P, GA3P TO FRU(6)P, E4P%REACTOME DATABASE ID RELEASE 76%6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P TALDO1 RHOT2 GTPASE CYCLE%REACTOME%R-HSA-9013419.1 RHOT2 GTPase cycle RHOT2 TRAK1 TRAK2 RAP1GDS1 MFN1 MFN2 MYO19 TP53 REGULATES TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-6791312.3 TP53 Regulates Transcription of Cell Cycle Genes CCNA1 GADD45A CCNE2 PLK2 CCNE1 TP53 BTG2 PCBP4 CDK2 TNKS1BP1 CNOT6L PRMT1 PLK3 PCNA PLAGL1 NPM1 SFN EP300 CNOT10 CNOT4 CNOT6 RGCC CNOT7 CNOT1 CNOT11 CNOT2 CNOT3 CNOT8 CDC25C CNOT9 RBL2 RBL1 E2F4 E2F7 E2F8 ARID3A BAX AURKA CCNB1 TFDP1 TFDP2 E2F1 CARM1 CENPJ CDK1 CDKN1A CDKN1B ZNF385A CCNA2 DEFECTIVE SLC35C1 CAUSES CONGENITAL DISORDER OF GLYCOSYLATION 2C (CDG2C)%REACTOME%R-HSA-5619078.1 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) SLC35C1 MITOCHONDRIAL TRANSCRIPTION TERMINATION%REACTOME%R-HSA-163316.3 Mitochondrial transcription termination MTERF1 NUCLEAR PORE COMPLEX (NPC) DISASSEMBLY%REACTOME DATABASE ID RELEASE 76%3301854 Nuclear Pore Complex (NPC) Disassembly NEK9 NUP42 NUP210 NEK6 NUP43 NEK7 RAE1 RANBP2 NUP93 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 CCNB2 CCNB1 NUP214 NUP153 SEC13 NUP62 NDC1 NUP133 CDK1 NUP107 NUP188 NUP50 NUP54 DEFECTIVE UGT1A4 CAUSES HYPERBILIRUBINEMIA%REACTOME DATABASE ID RELEASE 76%5579016 Defective UGT1A4 causes hyperbilirubinemia UGT1A4 BIOSYNTHESIS OF MARESINS%REACTOME DATABASE ID RELEASE 76%9018682 Biosynthesis of maresins ALOX5 EPHX2 CYP2C9 CYP2C8 CYP2D6 CYP1A2 CYP2E1 CYP3A4 DEFECTIVE DPM2 CAUSES DPM2-CDG (CDG-1U)%REACTOME%R-HSA-4719377.1 Defective DPM2 causes DPM2-CDG (CDG-1u) DPM1 DPM2 DPM3 HDL CLEARANCE%REACTOME%R-HSA-8964011.1 HDL clearance APOA1 CUBN HDLBP AMN GLUCAGON-LIKE PEPTIDE-1 (GLP1) REGULATES INSULIN SECRETION%REACTOME%R-HSA-381676.3 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion GNG3 GNG2 KCNB1 PRKACG GNG5 PRKACB GNG4 GNG7 GNG8 PRKAR1B KCNS3 KCNG2 PRKAR1A PRKAR2A ITPR1 ITPR2 GNG10 ITPR3 GNAS GNG12 GLP1R GNG11 PRKAR2B GNG13 GNB2 GNB1 GNB4 AKAP5 GNB3 GNB5 RAP1A KCNC2 ADCY8 GCG ADCY6 GNGT1 RAPGEF3 IQGAP1 ADCY5 RAPGEF4 GNGT2 PRKACA CREB PHOSPHORYLATION%REACTOME%R-HSA-199920.1 CREB phosphorylation MAPKAPK2 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 ATF1 CREB1 A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS%REACTOME%R-HSA-1971475.2 A tetrasaccharide linker sequence is required for GAG synthesis GPC5 GPC4 GPC6 CSPG5 CSPG4 B3GAT3 B3GALT6 SDC1 AGRN B4GALT7 XYLT2 XYLT1 B3GAT2 B3GAT1 DCN HSPG2 SDC4 BCAN SDC2 SDC3 NCAN GPC1 BGN GPC3 VCAN GPC2 CDC6 ASSOCIATION WITH THE ORC:ORIGIN COMPLEX%REACTOME%R-HSA-68689.2 CDC6 association with the ORC:origin complex ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 E2F1 E2F2 CDC6 MCM8 E2F3 DISSOLUTION OF FIBRIN CLOT%REACTOME DATABASE ID RELEASE 76%75205 Dissolution of Fibrin Clot SERPINF2 PLAUR ANXA2 SERPINB2 HRG PLAT SERPINE2 PLG SERPINB8 S100A10 SERPINE1 SERPINB6 PLAU MET ACTIVATES PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 76%8851907 MET activates PI3K AKT signaling PIK3R1 HGF MET GAB1 PIK3CA T(4;14) TRANSLOCATIONS OF FGFR3%REACTOME%R-HSA-2033515.1 t(4;14) translocations of FGFR3 FGFR3 INTERLEUKIN-35 SIGNALLING%REACTOME%R-HSA-8984722.3 Interleukin-35 Signalling STAT1 JAK2 IL27RA IL12A STAT3 IL6ST EBI3 STAT4 JAK1 IL12RB2 TYK2 CANX DEGRADATION OF GLI2 BY THE PROTEASOME%REACTOME DATABASE ID RELEASE 76%5610783 Degradation of GLI2 by the proteasome PRKACG PRKACB RBX1 GLI2 SUFU BTRC CSNK1A1 PRKACA SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 GSK3B PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PI-3K CASCADE:FGFR1%REACTOME%R-HSA-5654689.2 PI-3K cascade:FGFR1 GAB1 FGF1 FGF2 PIK3CA FGF3 FGF4 FGF6 PTPN11 FGF9 FGF20 FGF23 PIK3R1 FGF22 FRS2 FGF10 CHOLESTEROL BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%191273 Cholesterol biosynthesis TM7SF2 MVD PMVK SC5D FDFT1 FDPS HMGCS1 GGPS1 LBR CYP51A1 MSMO1 LSS NSDHL SQLE PLPP6 IDI2 ACAT2 DHCR7 EBP DHCR24 ARV1 HSD17B7 IDI1 MVK SYNTHESIS OF 5-EICOSATETRAENOIC ACIDS%REACTOME DATABASE ID RELEASE 76%2142688 Synthesis of 5-eicosatetraenoic acids GPX2 ALOX5 GPX1 GPX4 PON3 PON2 PON1 LTC4S ALOX5AP NEUROTRANSMITTER RECEPTORS AND POSTSYNAPTIC SIGNAL TRANSMISSION%REACTOME%R-HSA-112314.8 Neurotransmitter receptors and postsynaptic signal transmission GABRB3 PLCB3 GNAL GABRB2 PLCB1 PRKCB GABRB1 PLCB2 GABRR3 GABRR2 GABRR1 NPTN KPNA2 GABRG3 GABRG2 GABRQ GABRA2 GABRA1 GABRA6 GABRA5 GABRA4 GABRA3 MAPK1 RPS6KA3 RPS6KA2 TSPAN7 RPS6KA1 GNG10 MAPK3 GRIK5 GNAI3 GRIK4 EPB41L1 GNG12 GRIK1 PRKX GNG11 GRIK2 GNAI1 GNG13 GNAI2 GNB2 PRKAB2 GNB1 CACNG8 PRKAA2 GNB4 PRKAG1 PDPK1 CACNG2 CACNG3 GNB3 PRKAG2 PICK1 CACNG4 PRKAB1 CHRND GNB5 PRKAG3 GLRA1 GLRA2 GLRA3 CHRNG GNGT1 CHRNE GRIP1 PRKACA GNGT2 CHRNB2 CHRNB3 GRIP2 CHRNA1 CALM1 CHRNA3 CHRNA2 CHRNA5 GIT1 CHRNA4 CHRNA7 CHRNA6 PRKCG GNG3 HTR3E GNG2 HTR3C HTR3D GNG5 HTR3A GNG4 HTR3B GNG7 GNG8 NCALD PRKCA PRKAR2B CAMK2B GLRB CAMK2D CAMK2A CAMK2G CREB1 RAC1 CAMK4 SRC MDM2 PRKACG PRKACB ADCY9 CAMK1 ACTN2 PRKAR1B CAMKK1 RASGRF2 CAMKK2 PRKAR1A RASGRF1 KIF17 GRIN2B NRGN RPS6KA6 GRIN1 CASK GRIN2D GRIA2 DLG1 LIN7A PRKAR2A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIN2A GRIA3 GRIA4 GRIN2C GRIN3B GRIN3A NBEA APBA1 ADCY4 AKAP5 ADCY3 ADCY2 ADCY1 CHRNA9 AP2A1 ADCY8 ADCY7 ADCY6 GRIK3 ADCY5 NRG1 CHRNB4 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ10 ARHGEF9 KCNJ9 KCNJ12 KCNJ15 KCNJ16 PRKAA1 MYO6 GABBR2 GABBR1 GNAT3 HRAS NSF NRAS GRIA1 FGFR2C LIGAND BINDING AND ACTIVATION%REACTOME%R-HSA-190375.3 FGFR2c ligand binding and activation FGF23 FGF16 FGF1 FGF18 FGF2 FGF4 FGF6 FGF9 FGF20 SIGNALING BY NOTCH1 HD+PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%2894858 Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B MIB2 MIB1 HEYL EP300 PSEN2 CDK8 APH1A APH1B KAT2B KAT2A HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 JAG1 UBA52 CUL1 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 THREONINE CATABOLISM%REACTOME%R-HSA-8849175.2 Threonine catabolism SDSL GCAT TDH SDS RIDA RND1 GTPASE CYCLE%REACTOME%R-HSA-9696273.1 RND1 GTPase cycle DST STMN2 TXNL1 EPSTI1 VANGL1 DEPDC1B DLG5 FRS3 EPHA2 RND1 CAV1 TFRC GRB7 FAM135A ARHGAP5 ALDH3A2 ARHGAP35 FLOT2 MUC13 RRAS2 RBMX PLXNA1 FAM83B DSP ANKRD26 PLEKHG5 PTPN13 RASAL2 CCDC88A VANGL2 UBXN11 CPD KIDINS220 PKP4 LEMD3 TMEM59 PIK3R1 FRS2 KIF14 WDR6 PIK3R2 STIP1 SYNTHESIS OF ACTIVE UBIQUITIN: ROLES OF E1 AND E2 ENZYMES%REACTOME%R-HSA-8866652.2 Synthesis of active ubiquitin: roles of E1 and E2 enzymes USP9X UBE2B UBE2Z UBE2L3 UBE2Q2 UBE2E3 CDC34 UBA52 UBE2R2 UBA6 UBE2H UBE2G1 UBE2A UCHL3 UBE2G2 OTULIN UBE2W UBB UBE2T UBA1 UBC UBE2D2 RPS27A USP7 UBE2C UBE2E1 UBE2D1 UBE2S USP5 UBE2K METHYLATION%REACTOME DATABASE ID RELEASE 76%156581 Methylation NNMT MTRR MAT2B TPMT MAT2A GSTO1 AS3MT CYP1A2 N6AMT1 AHCY TRMT112 MAT1A COMT MTR COLLAGEN FORMATION%REACTOME%R-HSA-1474290.3 Collagen formation COL5A3 COL7A1 COL6A2 COL4A3 PLOD3 COL5A2 PLOD2 COL6A1 PLOD1 COL20A1 COL8A2 COL4A6 COL4A5 COL21A1 BMP1 COL8A1 COL9A1 COL6A3 COL9A3 COL6A6 PPIB COL9A2 COL18A1 COL6A5 COL14A1 CRTAP LAMC2 P4HA1 P4HA2 CTSS P4HA3 MMP20 COLGALT2 ADAMTS14 CTSL COLGALT1 PCOLCE2 CTSB MMP7 COL25A1 MMP3 MMP9 MMP13 COL15A1 LAMA3 COL19A1 COL26A1 LAMB3 TLL2 TLL1 COL16A1 ADAMTS2 COL12A1 ADAMTS3 P4HB ITGB4 LOXL3 LOXL4 LOXL1 LOXL2 PCOLCE LOX PXDN ITGA6 COL11A1 PLEC COL11A2 COL10A1 COL23A1 CD151 COL28A1 COL27A1 COL24A1 P3H2 COL22A1 P3H1 COL1A1 P3H3 COL3A1 COL2A1 SERPINH1 COL1A2 COL17A1 COL5A1 COL4A2 COL13A1 COL4A1 COL4A4 SYNTHESIS OF WYBUTOSINE AT G37 OF TRNA(PHE)%REACTOME DATABASE ID RELEASE 76%6782861 Synthesis of wybutosine at G37 of tRNA(Phe) TYW1 LCMT2 TRMT12 TRMT5 TYW5 TYW3 MET ACTIVATES RAP1 AND RAC1%REACTOME%R-HSA-8875555.1 MET activates RAP1 and RAC1 DOCK7 RAC1 CRKL HGF RAPGEF1 MET CRK GAB1 RAP1B RAP1A CELL-EXTRACELLULAR MATRIX INTERACTIONS%REACTOME%R-HSA-446353.1 Cell-extracellular matrix interactions ILK FERMT2 LIMS1 PARVA ACTN1 PXN FLNA ITGB1 FLNC LIMS2 ARHGEF6 FBLIM1 VASP TESK1 PARVB RSU1 TOLERANCE BY MTB TO NITRIC OXIDE PRODUCED BY MACROPHAGES%REACTOME%R-HSA-1222538.3 Tolerance by Mtb to nitric oxide produced by macrophages MT2748 mscR Rv1283c Rv1282c glbN ggt-1 trxA Rv1281c msrA tpx ahpE ahpC Rv1280c DUAL INCISION IN GG-NER%REACTOME DATABASE ID RELEASE 76%5696400 Dual Incision in GG-NER POLD2 POLE4 ERCC4 ERCC1 POLE2 POLE3 ERCC5 DDB2 PCNA RBX1 UBA52 UBB RFC5 GTF2H1 GTF2H2 UBC RFC3 POLK RFC4 GTF2H3 RFC2 GTF2H4 RPS27A POLE GTF2H5 PARP1 ERCC3 RFC1 ERCC2 PARP2 DDB1 XPA RPA1 CUL4A RPA2 CHD1L RPA3 POLD3 CUL4B POLD4 POLD1 FORMATION OF XYLULOSE-5-PHOSPHATE%REACTOME%R-HSA-5661270.2 Formation of xylulose-5-phosphate SORD AKR1A1 XYLB DCXR CRYL1 C6 DEAMINATION OF ADENOSINE%REACTOME DATABASE ID RELEASE 76%75102 C6 deamination of adenosine ADAR ADARB1 SIGNALING BY JUXTAMEMBRANE DOMAIN KIT MUTANTS%REACTOME%R-HSA-9669935.1 Signaling by juxtamembrane domain KIT mutants KIT APC C:CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS%REACTOME DATABASE ID RELEASE 76%176409 APC C:Cdc20 mediated degradation of mitotic proteins CCNA1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CCNB1 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PTTG1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDK1 CCNA2 ESTROGEN-DEPENDENT GENE EXPRESSION%REACTOME DATABASE ID RELEASE 76%9018519 Estrogen-dependent gene expression KCTD6 CREBBP CBFB RUNX1 POU2F1 KPNA2 CXCL12 YY1 KANK1 KDM1A HSP90AA1 MYB JUND FOSB GATA3 HSP90AB1 PTGES3 SMC3 DDX5 FKBP4 RAD21 GREB1 NR5A2 STAG1 TFF3 STAG2 AXIN1 TFF1 ZNF217 EBAG9 FOXA1 SMC1A CHD1 CXXC5 USF2 USF1 JUN CCND1 TNRC6C MOV10 MYC TNRC6A TNRC6B GPAM ATF2 CCNT1 ESR1 TGFA PRMT1 FOS GTF2A1 GTF2A2 NRIP1 SP1 PGR CDK9 AGO3 AGO4 POLR2A AGO1 POLR2B AGO2 POLR2C POLR2D POLR2E TLE3 POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L CTSD H2AC14 GTF2F1 H2BC21 KDM4B EP300 H2BU1 GTF2F2 H3-3B H3C8 H2AC8 TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ H2BC15 H2BC11 HDAC1 BCL2 H3C15 H2BS1 NCOA3 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 NCOA1 MED1 NCOA2 CARM1 CITED1 KAT5 TRANSMISSION ACROSS CHEMICAL SYNAPSES%REACTOME DATABASE ID RELEASE 76%112315 Transmission across Chemical Synapses PLCB3 PLCB1 PRKCB PLCB2 KPNA2 GAD1 GAD2 MAPK1 RPS6KA3 RPS6KA2 RPS6KA1 MAPK3 GNAI3 SLC1A2 EPB41L1 PRKX GNAI1 GNAI2 SLC1A6 SLC1A7 CACNG8 CACNG2 CACNG3 STX1A CACNG4 PRKACA PRKCG CACNB1 CACNB2 CACNB3 CACNB4 PRKAR2B SNAP25 RAC1 DNAJC5 SRC CAMK1 ACTN2 CAMKK1 CAMKK2 RASGRF2 KIF17 RASGRF1 GRIN2B NRGN RPS6KA6 GRIN1 GRIN2D CASK GRIA2 DLG1 LIN7A DLG2 LIN7C DLG3 LRRC7 PPM1E LIN7B DLG4 NEFL PPM1F GRIN2A GRIA3 GRIA4 GRIN2C GRIN3B GRIN3A NBEA UNC13B APBA1 SYN3 CPLX1 SYN2 RIMS1 AKAP5 PPFIA1 TSPOAP1 PPFIA4 PPFIA3 PPFIA2 AP2A1 CHRNA9 CHRNB4 SLC5A7 ARHGEF9 SLC1A1 SLC1A3 NSF SLC6A3 SLC22A2 SLC22A1 GABRB3 GABRB2 GNAL GABRB1 GABRR3 SYT1 GABRR2 GABRR1 NPTN GABRG3 GABRG2 GABRQ GABRA2 GABRA1 GABRA6 GABRA5 GABRA4 GABRA3 ABAT ARL6IP5 CACNA2D1 CACNA2D3 CACNA2D2 TSPAN7 SYN1 GNG10 GRIK5 GRIK4 GNG12 GRIK1 GNG11 GRIK2 GNG13 SLC6A4 GNB2 HSPA8 PRKAB2 GNB1 PRKAA2 PRKAG1 GNB4 PDPK1 ALDH5A1 PRKAG2 PICK1 GNB3 PRKAB1 CHRND PRKAG3 GLRA1 GNB5 GLRA2 GLRA3 CHRNG GNGT1 CHRNE SLC6A1 GNGT2 GRIP1 CHRNB2 CHRNB3 GRIP2 NAAA CALM1 SLC18A2 CHRNA1 CHRNA3 CHRNA2 GIT1 CHRNA5 CHRNA4 CHRNA7 CHRNA6 CHAT GLS CACNA1B CACNA1A CACNA1E GLUL GNG3 HTR3E GNG2 HTR3C HTR3D GNG5 HTR3A GNG4 SLC6A12 HTR3B GNG7 SLC6A11 LRTOMT GNG8 NCALD MAOA COMT PRKCA CAMK2B GLRB SLC38A1 CAMK2D CAMK2A CAMK2G ALDH2 CREB1 CAMK4 SLC38A2 MDM2 PRKACG PRKACB ADCY9 PRKAR1B PRKAR1A PRKAR2A ADCY4 ADCY3 ADCY2 ADCY1 ACHE ADCY8 ADCY7 BCHE ADCY6 GRIK3 ADCY5 SLC18A3 SLC6A13 NRG1 KCNJ2 KCNJ3 KCNJ4 KCNJ5 KCNJ6 KCNJ10 KCNJ9 KCNJ12 VAMP2 KCNJ15 KCNJ16 PRKAA1 MYO6 GABBR2 GABBR1 GNAT3 HRAS RAB3A NRAS SLC32A1 GRIA1 SLC17A7 GLS2 PYRIMIDINE BIOSYNTHESIS%REACTOME%R-HSA-500753.3 Pyrimidine biosynthesis UMPS DHODH CAD ELEVATION OF CYTOSOLIC CA2+ LEVELS%REACTOME%R-HSA-139853.3 Elevation of cytosolic Ca2+ levels TRPC7 TRPC6 TRPC3 P2RX7 P2RX6 P2RX5 STIM1 P2RX4 P2RX3 ORAI2 P2RX2 ORAI1 P2RX1 ITPR1 ITPR2 ITPR3 VIRAL RNP COMPLEXES IN THE HOST CELL NUCLEUS%REACTOME%R-HSA-168330.3 Viral RNP Complexes in the Host Cell Nucleus PA PB2 NP NS M HSPA1A PB1 INTERLEUKIN-1 PROCESSING%REACTOME%R-HSA-448706.1 Interleukin-1 processing GSDMD IL18 RELA IL1A CASP1 IL1B NFKB1 NFKB2 CTSG MAPK FAMILY SIGNALING CASCADES%REACTOME DATABASE ID RELEASE 76%5683057 MAPK family signaling cascades BRAP CSF2 FN1 BRAF DUSP16 DUSP8 DUSP9 VCL CNKSR2 APBB1IP CNKSR1 MRAS KIT FYN PAK3 MAPK1 SHOC2 MAPK3 PDGFB PEBP1 ARRB1 PDGFRB IL2 ARRB2 HGF IL3 ERBB2 MARK3 PPP1CB PPP2R1A DUSP10 KSR1 KSR2 PRKACA SPTB PIK3R2 RET CDC14B RAG2 RAG1 ETV4 MAPK6 MAPK4 SEPTIN7 ITGA2B UBA52 MAP2K1 MAP2K2 SHC3 IL6 UBB CCND3 UBC PTPRA RPS27A ITGB3 MYC RAC1 JAK2 PDE6D MET CDK1 EREG BTC SRC GOLGA7 FOXO3 SPTBN4 SPTBN5 TGFA FLT3 KRAS TLN1 SPTBN2 ACTN2 RASGRF2 RASGRF1 GRIN2B GRIN1 GRIN2D DLG1 DLG2 DLG3 ARTN LRRC7 DLG4 NEFL GFRA1 GFRA3 GFRA2 GFRA4 RANBP9 NRTN JAK1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSPN BCL2L1 FGB PSMD1 FGA PSMA5 PSMA6 VWF PSMA3 GDNF PSMA4 PSMA1 PSMA2 EPGN FGG PSME3 NCOA3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 NCAM1 PSMB6 PSMB7 PSMB4 PSMB5 MAPK12 PSMB2 PSMB3 KLB PSMB1 IRS1 PHB PSMF1 PAK2 PSMB8 IRS2 PSMB9 PIK3CB FGF1 SEM1 PSMC5 FGF2 PSMC6 FGF3 PSMC3 FGF4 PSMC4 FGF6 RASGRP1 PSMC1 FGF7 PSMC2 FGF9 RAP1B RAP1A FGF20 RAF1 FGF23 FGF22 FLT3LG FRS2 SPTA1 FGF16 FGF19 FGF18 FGFR4 FGF10 MAPKAPK5 PPP2R1B PPP2R5E PRKG2 FRS3 PPP2R5B RCE1 PPP2R5A PPP2R5D PPP2R5C ARL2 PPP2CA PPP2CB KALRN CDC42EP5 IL5RA CSF2RB CDC42EP3 IL2RG CDC42EP2 CSF2RA IL5 MAP3K11 IL2RB IL3RA PTPN11 USP17L2 PIK3R1 IQGAP1 CDC42 PAK1 CALM1 SPTAN1 SPTBN1 DNAJB1 EGF TYK2 YWHAB HSPB1 XPO1 DUSP4 DUSP6 DUSP7 PTK2 CAMK2B CSK CAMK2D JUN CAMK2A CDC14A CAMK2G PPP1CC TNRC6C MOV10 TNRC6A TNRC6B RASGRP4 IGF2BP1 PRKCQ SHC1 PIK3CA SOS1 PRKACG PRKACB RBX1 AGO3 AGO4 AGO1 AGO2 PPP5C SHC2 RALGDS AREG JAK3 IL6R NRG1 NRG2 NRG3 NRG4 CUL3 IL2RA RASGRP3 HBEGF FOXO1 EGFR ICMT ABHD17C ZDHHC9 ABHD17B SPRED3 ABHD17A FNTB SPRED2 SPRED1 SYNGAP1 HRAS PDGFRA RASA3 RASA4 RASA1 RASA2 RASAL1 WDR83 RASAL2 PAQR3 RASAL3 RGL3 NRAS LAMTOR2 RGL1 DAB2IP RGL2 NF1 PEA15 KBTBD7 LAMTOR3 DUSP5 DUSP2 DUSP1 FNTA ARAF IL17RD RAPGEF2 RASGEF1A ANGPT1 TEK PTPN7 LYPLA1 PTPN3 RAB GEFS EXCHANGE GTP FOR GDP ON RABS%REACTOME%R-HSA-8876198.3 RAB GEFs exchange GTP for GDP on RABs RAB6B RIN1 RIN2 TRAPPC2 DENND4B TRAPPC3 DENND4A DENND4C GAPVD1 TRAPPC1 CCZ1 ANKRD27 TRAPPC4 TRAPPC5 HPS1 HPS4 RAB39A TRAPPC8 RAB27A RAB39B TRAPPC9 RAB27B MON1A CCZ1B MON1B RAB3IP GDI1 GDI2 TRAPPC6A YWHAE RAB5A ALS2 DENND1C TRAPPC6B DENND1B RAB7A RAB8B DENND1A CHM RAB7B RAB8A DENND2D DENND2C DENND2B RAB1A DENND2A RAB3IL1 RAB1B ALS2CL DENND3 RAB21 RGP1 RAB10 RAB3GAP2 RAB9A RAB14 RAB12 RAB13 RAB9B AKT2 RAB18 RAB3GAP1 DENND5B AKT1 TRAPPC12 TRAPPC11 DENND5A TRAPPC13 CHML SBF1 RIC1 SBF2 TRAPPC10 RINL RAB3A TRAPPC2L RAB32 DENND6B DENND6A RAB31 RAB35 RAB38 RAB5B RAB5C RABGEF1 ULK1 RIN3 RAB6A AKT3 ACTIVATION OF THE TFAP2 (AP-2) FAMILY OF TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 76%8866907 Activation of the TFAP2 (AP-2) family of transcription factors CREBBP TFAP2C TFAP2E CITED2 CITED1 CITED4 WWOX YEATS4 EP300 TFAP2A TFAP2B TFAP2D INTERCONVERSION OF POLYAMINES%REACTOME%R-HSA-351200.1 Interconversion of polyamines SAT1 PAOX MISCELLANEOUS TRANSPORT AND BINDING EVENTS%REACTOME DATABASE ID RELEASE 76%5223345 Miscellaneous transport and binding events SLC66A1 AZGP1 LRRC8A NIPA2 LRRC8B MRS2 LRRC8E DMTN ADD3 ANKH CTNS ADD1 MMGT1 ADD2 NIPAL4 NIPAL1 NIPAL2 NIPAL3 TUSC3 MAGT1 LRRC8C NIPA1 PIP LRRC8D PTEN LOSS OF FUNCTION IN CANCER%REACTOME%R-HSA-5674404.1 PTEN Loss of Function in Cancer PTEN DEFECTIVE CYP11A1 CAUSES AICSR%REACTOME DATABASE ID RELEASE 76%5579026 Defective CYP11A1 causes AICSR FDXR CYP11A1 FDX1 FDX2 RHOC GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9013106 RHOC GTPase cycle CAVIN1 DIAPH1 DLC1 DAAM1 TJP2 IQGAP3 RTKN TFRC STARD13 ARHGDIA JUP MCF2L RHOC ARHGAP1 ARHGAP39 ARHGAP5 ARHGEF40 FLOT1 ARHGAP35 ARHGEF5 ARHGEF25 PREX1 ARHGAP18 CIT OPHN1 PKN3 ACBD5 ERBIN VAPB LBR MACO1 TMPO MYO9B VAV2 PIK3R1 BCR IQGAP1 ABCD3 CCDC187 VAMP3 FMNL3 PKN2 ARHGEF10L FMNL2 PKN1 AKAP13 LMAN1 ARHGAP21 ABR C1QBP ARHGEF11 ARHGEF10 RACGAP1 STK10 ARHGEF12 SLK VANGL1 ARHGEF17 DEPDC1B ROCK1 ARHGEF1 ROCK2 CAV1 MCAM STOM MCF2 ARHGAP26 ARHGAP32 DIAPH3 ARHGEF28 FLOT2 STX5 ANLN RHOA PHAGOCYTE CELL DEATH CAUSED BY CYTOSOLIC MTB%REACTOME DATABASE ID RELEASE 76%9637698 Phagocyte cell death caused by cytosolic Mtb cpnT DUAL INCISION IN TC-NER%REACTOME DATABASE ID RELEASE 76%6782135 Dual incision in TC-NER POLD2 POLE4 ERCC4 ERCC1 POLE2 POLE3 ERCC5 RBX1 PCNA CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L RFC5 GTF2H1 GTF2H2 RFC3 RFC4 GTF2H3 EP300 RFC2 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RPA1 RPA2 RPA3 UBA52 ERCC6 UBB UBC POLK ISY1 POLE RPS27A PRPF19 HMGN1 USP7 AQR RFC1 DDB1 PPIE ZNF830 XPA CUL4A XAB2 UVSSA ERCC8 TCEA1 POLD3 CUL4B POLD4 POLD1 THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514856.1 The phototransduction cascade METAP2 PDE6B PDE6A NMT2 PDE6G RGS9BP GNAT1 CNGA1 SAG SLC24A1 GRK1 GUCA1B FNTB GUCA1A GRK7 PRKCA GUCY2D GUCA1C GUCY2F GNB1 RHO CNGB1 NMT1 GNGT1 FNTA PRKCQ RCVRN CALM1 CAMKMT PPEF1 METAP1 DEFECTIVE AVP DOES NOT BIND AVPR2 AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-9036092.2 Defective AVP does not bind AVPR2 and causes neurohypophyseal diabetes insipidus (NDI) AVPR2 AVP MELANIN BIOSYNTHESIS%REACTOME%R-HSA-5662702.2 Melanin biosynthesis DCT TYRP1 TYR OCA2 SLC45A2 DISEASES OF CELLULAR RESPONSE TO STRESS%REACTOME DATABASE ID RELEASE 76%9675132 Diseases of cellular response to stress CDK6 CDKN2A CDK4 DEFECTIVE MAT1A CAUSES MATD%REACTOME DATABASE ID RELEASE 76%5579024 Defective MAT1A causes MATD MAT1A COMPLEX I BIOGENESIS%REACTOME%R-HSA-6799198.1 Complex I biogenesis NDUFB4 NDUFB3 NDUFB2 NDUFB1 NDUFA9 NDUFA8 NDUFA7 TIMMDC1 NDUFA6 NUBPL NDUFA3 NDUFA2 NDUFA1 NDUFS3 NDUFA5 NDUFAB1 NDUFB8 MT-ND6 MT-ND4 NDUFA13 MT-ND5 NDUFA11 NDUFA12 NDUFA10 MT-ND2 MT-ND3 MT-ND1 TMEM126B NDUFB10 NDUFB11 NDUFV3 NDUFV2 NDUFV1 COA1 NDUFAF6 NDUFAF7 NDUFAF4 NDUFAF5 NDUFAF2 ECSIT NDUFAF3 NDUFAF1 TMEM186 NDUFC2 ACAD9 NDUFC1 NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 BETAKLOTHO-MEDIATED LIGAND BINDING%REACTOME%R-HSA-1307965.1 betaKlotho-mediated ligand binding KLB FGF19 FGFR4 VLDL CLEARANCE%REACTOME%R-HSA-8964046.1 VLDL clearance APOBR LSR VLDLR APOC1 APOB APOC4 AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE%REACTOME%R-HSA-352230.3 Amino acid transport across the plasma membrane SLC3A2 SLC43A1 SLC3A1 SLC7A6 SLC6A19 SLC7A8 SLC7A1 SLC6A18 SLC7A3 SLC6A14 SLC36A1 SLC36A4 SLC6A12 SLC7A5 SLC25A29 SLC1A4 SLC6A20 SLC38A1 SLC7A11 SLC7A10 SLC16A10 SLC6A6 SLC38A3 SLC38A2 SLC36A2 SLC38A5 SLC38A4 SLC7A7 SLC7A9 SLC1A5 SLC6A15 SLC43A2 MET PROMOTES CELL MOTILITY%REACTOME%R-HSA-8875878.1 MET promotes cell motility LAMB3 LAMB1 CRK GAB1 TNS4 TNS3 ITGB1 LAMC2 LAMC1 LAMC3 LAMA2 LAMA1 ITGA3 LAMA4 DOCK7 CRKL PTK2 HGF RAP1B RAP1A RAC1 ITGA2 RAPGEF1 LAMA5 LAMB2 MET LAMA3 SRC DEGRADATION OF DVL%REACTOME%R-HSA-4641258.2 Degradation of DVL RBX1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 PSME1 PSME2 DVL1 UBA52 PSMD10 PSMB11 PSMD12 DVL3 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 HECW1 UBC PSMB8 PSMB9 KLHL12 RPS27A SEM1 PSMC5 DACT1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 DVL2 DISEASES ASSOCIATED WITH O-GLYCOSYLATION OF PROTEINS%REACTOME DATABASE ID RELEASE 76%3906995 Diseases associated with O-glycosylation of proteins ADAMTS16 DAG1 ADAMTS18 POMGNT1 POMT2 POMT1 B3GLCT ADAMTS12 ADAMTS4 ADAMTS10 ADAMTS5 THBS2 ADAMTS15 ADAMTS14 ADAMTS13 ADAMTS1 THBS1 MUC1 ADAMTS19 MUC2 ADAMTS17 B4GAT1 ADAMTS8 MUC7 MUC4 ADAMTS9 MUC6 CFP MUC5AC ADAMTS20 THSD7B C1GALT1C1 THSD7A SPON2 SPON1 SBSPON MUC12 MUC15 SSPOP MUC3A MUC3B MUC16 MUC17 GALNT3 MUC19 SEMA5A MUC20 MUC21 MUC5B NOTCH2 ADAMTSL1 LFNG ADAMTSL5 NOTCH3 ADAMTSL4 NOTCH4 ADAMTSL3 ADAMTSL2 MUC13 LARGE1 ADAMTS2 ADAMTS3 ADAMTS6 ADAMTS7 THSD1 THSD4 SEMA5B MUCL1 C1GALT1 GALNT12 NOTCH1 EGFR DOWNREGULATION%REACTOME%R-HSA-182971.6 EGFR downregulation EPS15L1 EPS15 PTPRK TGFA SPRY1 EGF ARHGEF7 EPGN SPRY2 UBA52 HBEGF EGFR STAM SH3GL3 EPN1 SH3KBP1 UBB SH3GL2 UBC SH3GL1 HGS RPS27A PTPN12 STAM2 AREG CDC42 EREG PTPN3 BTC CBL EPH-EPHRIN SIGNALING%REACTOME%R-HSA-2682334.1 EPH-Ephrin signaling PSEN1 NCSTN EPHA5 EPHA4 EPHA7 EPHA6 EPHA8 EPHB6 EPHA1 MYL12A EFNB2 EPHA3 EFNB1 ARPC4 SDCBP EFNB3 EPHA10 FYN ARPC5 VAV3 MYL12B PAK3 GRIN2B EPHB2 GRIN1 EPHB1 EPHB4 EPHB3 ARPC2 ARPC3 DNM1 KALRN ACTB MMP2 NGEF MMP9 PSEN2 MYH9 APH1A ACTR2 CLTA APH1B CLTC ARPC1A AP2A1 CLTB WASL VAV2 AP2A2 TIAM1 CDC42 PAK1 NCK2 AP2M1 EFNA5 GIT1 EFNA4 MYL6 MYH14 PSENEN MYH11 MYL9 MYH10 EFNA1 EFNA3 EFNA2 ARHGEF7 EPHA2 ROCK1 ROCK2 AP2S1 ARHGEF28 ARPC1B ACTG1 CFL1 LYN YES1 LIMK2 LIMK1 AP2B1 PTK2 HRAS PAK2 RASA1 RAC1 ADAM10 SDC2 ITSN1 RHOA CLTCL1 GSD II%REACTOME DATABASE ID RELEASE 76%5357609 GSD II GAA GYG1 NEUREXINS AND NEUROLIGINS%REACTOME%R-HSA-6794361.4 Neurexins and neuroligins SYT2 SYT1 SYT9 HOMER3 EPB41 GRIN2B STXBP1 GRIN1 CASK EPB41L5 GRIN2D EPB41L2 LIN7A DLG2 LIN7C HOMER1 DLG3 HOMER2 LIN7B DLG4 GRIN2A EPB41L1 EPB41L3 GRIN2C SIPA1L1 DLGAP1 APBA1 DLGAP3 DLGAP2 DLGAP4 STX1A BEGAIN SHARPIN APBA3 APBA2 SYT7 LRRTM3 GRM1 LRRTM4 LRRTM1 LRRTM2 GRM5 SHANK2 SHANK1 NLGN3 SHANK3 NLGN1 NLGN2 NRXN1 NRXN3 NRXN2 PDLIM5 NLGN4Y NLGN4X SYT12 SYT10 DBNL DEFECTIVE SLC20A2 CAUSES IDIOPATHIC BASAL GANGLIA CALCIFICATION 1 (IBGC1)%REACTOME%R-HSA-5619111.1 Defective SLC20A2 causes idiopathic basal ganglia calcification 1 (IBGC1) SLC20A2 ATF4 ACTIVATES GENES IN RESPONSE TO ENDOPLASMIC RETICULUM STRESS%REACTOME DATABASE ID RELEASE 76%380994 ATF4 activates genes in response to endoplasmic reticulum stress NFYA NFYB CCL2 NFYC CXCL8 ASNS KHSRP DIS3 ATF6 HERPUD1 DCP2 PARN EXOSC7 EXOSC6 EXOSC5 CEBPB EXOSC4 EXOSC9 CEBPG EXOSC8 EXOSC3 IGFBP1 EXOSC2 EXOSC1 DDIT3 ATF3 ATF4 DEFECTIVE OGG1 SUBSTRATE PROCESSING%REACTOME DATABASE ID RELEASE 76%9656256 Defective OGG1 Substrate Processing OGG1 CONJUGATION OF CARBOXYLIC ACIDS%REACTOME%R-HSA-159424.1 Conjugation of carboxylic acids ACSM1 ACSM5 ACSM4 ACSM2B GLYATL3 GLYAT GLYATL2 GLYATL1 ACSM2A SIGNALING BY ERBB2%REACTOME%R-HSA-1227986.7 Signaling by ERBB2 NRG1 NRG2 MEMO1 NRG3 NRG4 SHC1 GAB1 PIK3CA PLCG1 DIAPH1 SOS1 EGF UBA52 HBEGF GRB7 FYN EGFR AKT2 AKT1 YES1 RNF41 UBB PRKCD PRKCA HSP90AA1 HRAS CDC37 UBC ERBB2 ERBIN RPS27A PRKCE PTPN12 CUL5 NRAS STUB1 PTK6 PIK3R1 USP8 EREG RHOA BTC SRC PTPN18 MATK AKT3 RAF ACTIVATION%REACTOME%R-HSA-5673000.2 RAF activation BRAP PPP2R1B PPP2R5E BRAF PPP2R5B PPP2R5A PPP2R5D PPP2R5C MAP2K1 MRAS MAP2K2 YWHAB SHOC2 PPP2CA PPP2CB CAMK2B PHB CAMK2D HRAS CAMK2A MARK3 MAP3K11 CAMK2G PPP1CC PPP1CB NRAS PPP2R1A RAF1 KSR1 ARAF JAK2 CALM1 SRC MECP2 REGULATES TRANSCRIPTION OF GENES INVOLVED IN GABA SIGNALING%REACTOME DATABASE ID RELEASE 76%9022927 MECP2 regulates transcription of genes involved in GABA signaling GAD1 GAD2 SIGNALING BY FGFR4 IN DISEASE%REACTOME%R-HSA-5655291.1 Signaling by FGFR4 in disease PIK3R1 HRAS FRS2 GAB1 PIK3CA PLCG1 SOS1 NRAS FGFR4 POST-TRANSLATIONAL MODIFICATION: SYNTHESIS OF GPI-ANCHORED PROTEINS%REACTOME DATABASE ID RELEASE 76%163125 Post-translational modification: synthesis of GPI-anchored proteins LYPD8 LYPD6B PIGS PIGU PIGT PIGO PIGN OTOA PIGP RAET1G PIGZ VNN3 PIGW RAET1L PIGV IZUMO1R PIGY PIGX CEACAM7 PIGC NRN1L PIGB CEACAM5 PIGA PIGK PIGM LY6G6C BST1 PIGL LY6G6D LSAMP PIGG PIGF PIGH ALPI DPM1 DPM2 DPM3 NTM ULBP2 OPCML LY6K NEGR1 XPNPEP2 LY6D LY6H LY6E SPRN SPACA4 MDGA2 MDGA1 RECK NRN1 ART3 ART4 NTNG1 NTNG2 VNN1 GPAA1 VNN2 CD52 PRND CNTN5 ALPL CNTN3 CNTN4 ALPG TEX101 CD109 GPLD1 GP2 PRSS21 GPIHBP1 MELTF FOLR2 MSLN PRSS41 PLAUR FCGR3B TECTA TECTB PLET1 CPM PSCA RTN4RL2 RTN4RL1 PGAP1 LYPD1 LYPD2 LYPD3 LYPD4 THY1 LYPD5 MITOPHAGY%REACTOME DATABASE ID RELEASE 76%5205647 Mitophagy TOMM22 TOMM40 VDAC1 MFN1 MFN2 CSNK2A1 UBA52 CSNK2A2 CSNK2B TOMM7 TOMM5 TOMM6 TOMM70 UBB PRKN UBC SQSTM1 RPS27A MAP1LC3B MTERF3 ATG5 ATG12 MAP1LC3A TOMM20 FUNDC1 PINK1 ULK1 DRUG RESISTANCE IN ERBB2 KD MUTANTS%REACTOME DATABASE ID RELEASE 76%9665230 Drug resistance in ERBB2 KD mutants HSP90AA1 CDC37 ERBB2 ERBIN BETA OXIDATION OF LAUROYL-COA TO DECANOYL-COA-COA%REACTOME DATABASE ID RELEASE 76%77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA HADHB HADH HADHA ACADL ECHS1 ERYTHROPOIETIN ACTIVATES RAS%REACTOME%R-HSA-9027284.1 Erythropoietin activates RAS CRKL JAK2 HRAS RAPGEF1 EPOR IRS2 SHC1 VAV1 SOS1 NRAS LYN EPO ERYTHROPOIETIN ACTIVATES PHOSPHOINOSITIDE-3-KINASE (PI3K)%REACTOME%R-HSA-9027276.1 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) PIK3R1 JAK2 EPOR IRS2 PIK3CB GAB1 PIK3CA PIK3CG PIK3R5 LYN EPO PIK3CD SHC-MEDIATED CASCADE:FGFR1%REACTOME DATABASE ID RELEASE 76%5654688 SHC-mediated cascade:FGFR1 HRAS FGF1 FGF2 FGF3 FGF4 SOS1 FGF6 NRAS FGF9 FGF20 FGF23 FGF22 FGF10 ABASIC SUGAR-PHOSPHATE REMOVAL VIA THE SINGLE-NUCLEOTIDE REPLACEMENT PATHWAY%REACTOME%R-HSA-73930.2 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway APEX1 POLB TAT-MEDIATED ELONGATION OF THE HIV-1 TRANSCRIPT%REACTOME DATABASE ID RELEASE 76%167246 Tat-mediated elongation of the HIV-1 transcript CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P tat ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 TCEA1 TRANSMISSION ACROSS ELECTRICAL SYNAPSES%REACTOME DATABASE ID RELEASE 76%112307 Transmission across Electrical Synapses GJC1 GJD2 PANX2 PANX1 GJA10 TELOMERE MAINTENANCE%REACTOME DATABASE ID RELEASE 76%157579 Telomere Maintenance CCNA1 POLD2 BLM NOP10 ANKRD28 CDK2 PRIM2 PRIM1 POLA1 POLA2 PCNA POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L RFC5 H2AC14 RFC3 H2BC21 RFC4 PPP6C RFC2 DSCC1 H2BU1 H3-3B RUVBL2 PPP6R3 H2AC8 SHQ1 ACD H2AC6 TINF2 PIF1 WRN H2AC7 TERF1 CHTF8 TERF2 TERT H2BC17 CTC1 H2BC12 WRAP53 CHTF18 H2BC13 RPA1 H3-4 H2BC14 POT1 STN1 RPA2 H2AJ TERF2IP H2BC15 TEN1 RPA3 H2BC11 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RTEL1 RUVBL1 DAXX LIG1 ATRX DKC1 RFC1 NHP2 GAR1 POLD3 FEN1 POLD4 CCNA2 DNA2 POLD1 RHO GTPASES ACTIVATE CIT%REACTOME DATABASE ID RELEASE 76%5625900 RHO GTPases activate CIT CIT MYL6 MYH14 MYH11 MYL9 MYH10 PRC1 PPP1CB MYH9 RAC1 RHOC MYL12B RHOB KIF14 RHOA CDKN1B PPP1R12A DLG4 PPP1R12B SCAVENGING BY CLASS H RECEPTORS%REACTOME%R-HSA-3000497.1 Scavenging by Class H Receptors SPARC STAB1 APOB STAB2 DEFECTIVE CYP1B1 CAUSES GLAUCOMA%REACTOME DATABASE ID RELEASE 76%5579000 Defective CYP1B1 causes Glaucoma CYP1B1 TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3:SMAD4 HETEROTRIMER%REACTOME%R-HSA-2173793.2 Transcriptional activity of SMAD2 SMAD3:SMAD4 heterotrimer CCNT1 HDAC1 WWTR1 USP9X SMAD7 SMAD4 MEN1 SMAD3 SMURF2 SNW1 RBL1 SP1 E2F4 CDK9 UBA52 E2F5 TRIM33 NEDD4L CCNT2 UBB PPM1A TFDP1 UBC TFDP2 UBE2D3 RPS27A SKI RNF111 TGIF1 PARP1 CDK8 TGIF2 NCOR2 NCOR1 MYC CCNK UBE2D1 CCNC SKIL JUNB CDKN2B SMAD2 SERPINE1 ATP1B4 PYRUVATE METABOLISM AND CITRIC ACID (TCA) CYCLE%REACTOME DATABASE ID RELEASE 76%71406 Pyruvate metabolism and Citric Acid (TCA) cycle OGDH PDHB MDH2 DLAT RXRA SLC16A1 FAHD1 SUCLA2 DLD GSTZ1 DLST CS PPARD ACO2 ADHFE1 D2HGDH L2HGDH VDAC1 PDHA2 PDHX PDHA1 SDHC SDHD IDH3G SDHA SDHB SUCLG2 SUCLG1 IDH2 SLC16A8 SLC16A3 NNT BSG IDH3B ME3 ME2 IDH3A GLO1 LDHC LDHB LDHA PDPR MPC1 MPC2 PDK4 ME1 PDK3 PDK2 PDK1 PDP1 FH PDP2 LDHAL6A LDHAL6B DNA REPLICATION PRE-INITIATION%REACTOME%R-HSA-69002.2 DNA Replication Pre-Initiation POLE4 POLE2 CDK2 POLE3 PRIM2 PRIM1 POLA1 POLA2 MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 RPA1 RPA2 RPA3 GMNN PSMD8 PSMD9 PSMD6 MCM10 PSMD7 PSMD4 DBF4 PSMD5 PSMD2 RPA4 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CDC45 PSME1 PSME2 CDC7 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 POLE RPS27A SEM1 PSMC5 E2F1 PSMC6 E2F2 PSMC3 E2F3 PSMC4 PSMC1 PSMC2 ASSEMBLY OF VIRAL COMPONENTS AT THE BUDDING SITE%REACTOME DATABASE ID RELEASE 76%168316 Assembly of Viral Components at the Budding Site NP NA HA M CALR CANX FGFR1C AND KLOTHO LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190374 FGFR1c and Klotho ligand binding and activation FGF23 CONSTITUTIVE SIGNALING BY NOTCH1 HD DOMAIN MUTANTS%REACTOME DATABASE ID RELEASE 76%2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants UBB JAG2 NEURL1 UBC RPS27A JAG1 UBA52 ADAM10 NEURL1B ADAM17 DLL1 NOTCH1 MIB2 MIB1 DLL4 KANDUTSCH-RUSSELL PATHWAY%REACTOME DATABASE ID RELEASE 76%6807062 Kandutsch-Russell pathway SC5D DHCR7 EBP DHCR24 INFLUENZA VIRUS INDUCED APOPTOSIS%REACTOME DATABASE ID RELEASE 76%168277 Influenza Virus Induced Apoptosis TGFB1 NA SLC25A6 PB1 DEFECTIVE MMAB CAUSES METHYLMALONIC ACIDURIA TYPE CBLB%REACTOME DATABASE ID RELEASE 76%3359471 Defective MMAB causes methylmalonic aciduria type cblB MMAB SIGNALING BY FGFR3%REACTOME DATABASE ID RELEASE 76%5654741 Signaling by FGFR3 BRAF GAB1 PIK3CA PLCG1 FRS3 SOS1 MKNK1 GALNT3 SPRY2 UBA52 MAPK1 MAPK3 PPP2CA PPP2CB UBB HRAS UBC FGF1 RPS27A FGF2 FGF4 NRAS PTPN11 FGF9 FGF20 PPP2R1A FGF23 PIK3R1 FRS2 FGF16 FGF18 CBL DEFECTIVE ALG11 CAUSES ALG11-CDG (CDG-1P)%REACTOME DATABASE ID RELEASE 76%4551295 Defective ALG11 causes ALG11-CDG (CDG-1p) ALG11 GRB2 EVENTS IN EGFR SIGNALING%REACTOME DATABASE ID RELEASE 76%179812 GRB2 events in EGFR signaling HBEGF HRAS AREG TGFA EGFR EREG BTC SOS1 NRAS EGF EPGN FGFR3 LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190239 FGFR3 ligand binding and activation FGF23 FGF16 FGF1 FGF18 FGF2 FGF4 GALNT3 FGF9 FGF20 TRISTETRAPROLIN (TTP, ZFP36) BINDS AND DESTABILIZES MRNA%REACTOME%R-HSA-450513.2 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA DIS3 XRN1 MAPKAPK2 DCP2 EXOSC7 EXOSC6 EXOSC5 EXOSC4 EXOSC9 EXOSC8 EXOSC3 EXOSC2 EXOSC1 YWHAB DCP1A ZFP36 TNPO1 ACTIVATED NTRK2 SIGNALS THROUGH PLCG1%REACTOME DATABASE ID RELEASE 76%9026527 Activated NTRK2 signals through PLCG1 NTF4 BDNF PLCG1 NTRK2 ESR-MEDIATED SIGNALING%REACTOME%R-HSA-8939211.3 ESR-mediated signaling KCTD6 CREBBP CBFB RUNX1 POU2F1 KPNA2 CXCL12 STRN YY1 KANK1 ELK1 MAPK1 GNG10 MAPK3 GNAI3 KDM1A GNG12 GNG11 GNAI1 GNG13 HSP90AA1 GNAI2 GNB2 MYB JUND GNB1 NOS3 ESR2 GNB4 PDPK1 GNB3 GNB5 FOSB PIK3R1 GNGT1 GNGT2 GATA3 SPHK1 CALM1 PIK3R2 HSP90AB1 PTGES3 SMC3 DDX5 FKBP4 GNG3 FKBP5 GNG2 S1PR3 EGF GNG5 ZDHHC7 RAD21 GNG4 GNG7 GREB1 CAV1 NR5A2 GNG8 STAG1 TFF3 STAG2 AXIN1 TFF1 ZNF217 EBAG9 FOXA1 PPID CAV2 SMC1A CHD1 CXXC5 XPO1 USF2 USF1 AKT1 SRF PTK2 JUN CCND1 TNRC6C MOV10 CREB1 MYC TNRC6A TNRC6B GPAM EREG ATF2 BTC CDKN1B SRC AKT3 FOXO3 CCNT1 ESR1 TGFA PIK3CA PRMT1 FOS GTF2A1 GTF2A2 NRIP1 SP1 PGR CDK9 AGO3 AGO4 POLR2A AGO1 POLR2B AGO2 POLR2C POLR2D POLR2E TLE3 POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L CTSD MMP7 H2AC14 GTF2F1 UHMK1 H2BC21 KDM4B EP300 MMP2 H2BU1 GTF2F2 MMP3 H3-3B H3C8 MMP9 H2AC8 PPP5C TBP H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ AREG H2BC15 H2BC11 IGF1R HDAC1 BCL2 H3C15 H2BS1 EPGN NCOA3 H2AZ1 H2BC9 HBEGF H2AZ2 H4C9 H2BC8 H2BC5 EGFR H2BC3 AKT2 H2BC1 H2AC20 NCOA1 MED1 GNAT3 HRAS NCOA2 NRAS CARM1 CITED1 PIK3R3 KAT5 PRKCZ ZDHHC21 PTK6 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 76%8849472 PTK6 Down-Regulation PTK6 PTPN1 SRMS SYNTHESIS OF IP2, IP, AND INS IN THE CYTOSOL%REACTOME%R-HSA-1855183.5 Synthesis of IP2, IP, and Ins in the cytosol ISYNA1 INPP1 IMPA1 IMPA2 MIOX OCRL INPP5A MTMR9 INPP4A MTMR7 INPP5B INPP4B SYNJ1 INPP5J INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS%REACTOME DATABASE ID RELEASE 76%141405 Inhibition of the proteolytic activity of APC C required for the onset of anaphase by mitotic spindle checkpoint components CDC20 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 HCMV EARLY EVENTS%REACTOME DATABASE ID RELEASE 76%9609690 HCMV Early Events HDAC3 H2AC17 H2AC12 NUP42 NUP43 RAE1 RANBP2 SCP ITGB1 NUP35 CVC2 CVC1 NUP37 H2AC21 H2AW ELK1 NEC1 NEC2 US12 US11 US10 US28 US27 US26 US24 US34 US30 US19 US18 US17 US16 US14 US13 US23 US22 US20 NFKB1 H2AC1 DYNLL2 UL103 UL102 DYNLL1 UL104 EZH2 H2BC18 DYNC1I2 EED PML NUP214 SUZ12 GPS2 UL119/UL118 UL11 DAXX UL17 NCOR2 UL16 UL13 DYNC1H1 UL32 CREB1 NCOR1 HELI UL38 UL37 UL35 UL34 UL27 UL26 UL25 UL24 UL23 UL54 DBP CBX1 UL44 UL43 UL48 UL47 UL76 UL74 UL71 DYNC1LI1 DYNC1LI2 UL79 UL78 UL131A UL69 UL112/UL113 UL99 UL98 UL97 UL96 UL36 UL95 UL94 RIR1 H2AC19 UL88 H2AC14 UL84 H2BC21 UL83 UL82 H2BU1 UL4 H3C8 H2AC8 UL5 H2AC6 H2AC7 SEC13 H2BC17 US3 H2BC12 US2 H2BC13 US9 US8 H2BC14 MCP H2BC15 DUT NUP107 RL11 NUP188 RL10 H2BC11 US33A US34A H3C15 DYNC1I1 NUP210 RBBP4 NUP93 POM121 RBBP7 NUP205 UL130 H2BC9 UL132 UL133 AAAS H4C9 UL138 H2BC8 NUP160 H2BC5 POM121C NUP85 EGFR H2BC3 TPR NUP88 H2BC1 TRIM28 NUP155 gB gH gL NUP153 H2AC20 gM gN UL114 IRS1 UL123 UL122 UL124 TRS1 TBL1XR1 RL1 TBL1X NUP62 TRX1 NDC1 TRX2 UL111A NUP133 UL21A NUP50 NUP54 O-GLYCOSYLATION OF TSR DOMAIN-CONTAINING PROTEINS%REACTOME DATABASE ID RELEASE 76%5173214 O-glycosylation of TSR domain-containing proteins SBSPON ADAMTS16 ADAMTS18 SSPOP SEMA5A B3GLCT ADAMTS12 ADAMTS10 ADAMTS4 THBS2 ADAMTS15 ADAMTS5 ADAMTS14 ADAMTSL1 ADAMTS13 THBS1 ADAMTSL5 ADAMTS1 ADAMTS19 ADAMTSL4 ADAMTSL3 ADAMTS17 ADAMTSL2 ADAMTS2 ADAMTS8 ADAMTS3 ADAMTS9 ADAMTS6 ADAMTS7 THSD1 THSD4 POFUT2 CFP SEMA5B ADAMTS20 THSD7B THSD7A SPON2 SPON1 SCAVENGING BY CLASS B RECEPTORS%REACTOME%R-HSA-3000471.2 Scavenging by Class B Receptors APOA1 SAA1 SSC5D APOB CD36 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN DIFFERENTIATION OF KERATINOCYTES%REACTOME DATABASE ID RELEASE 76%8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes CBFB SOCS4 RUNX1 SERPINB13 CTSL CTSK SOCS3 TERMINATION OF O-GLYCAN BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%977068 Termination of O-glycan biosynthesis MUC12 MUC15 ST3GAL3 MUC3A MUC3B MUC16 MUC17 MUC19 MUC20 MUC21 MUC5B ST6GALNAC2 MUC1 MUC2 MUC13 MUC7 MUC4 MUC6 ST3GAL4 ST3GAL1 ST3GAL2 ST6GAL1 ST6GALNAC3 ST6GALNAC4 MUCL1 MUC5AC SYNTHESIS OF DNA%REACTOME DATABASE ID RELEASE 76%69239 Synthesis of DNA RFC5 RFC3 RFC4 RFC2 RPA1 RPA2 RPA3 SKP1 UBA52 CUL1 UBB UBC POLE RPS27A LIG1 RFC1 POLD3 POLD4 CCNA2 POLD1 CCNA1 POLD2 CCNE2 CCNE1 POLE4 CDK2 POLE2 POLE3 PRIM2 PRIM1 POLA1 POLA2 RBX1 PCNA MCM7 MCM8 SKP2 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 FZR1 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 GINS1 PSME3 GINS2 PSME4 CDC45 PSME1 GINS3 PSME2 GINS4 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 FEN1 DNA2 STIMULI-SENSING CHANNELS%REACTOME%R-HSA-2672351.4 Stimuli-sensing channels TRPC7 FKBP1B TRPC6 TRPC3 TTYH3 TTYH2 TRPC4AP SCNN1G SCNN1D CLCNKB SCNN1B NEDD4L SCNN1A CLCNKA SRI NALCN ASIC4 ASIC5 ASIC2 ASIC3 SGK1 ASIC1 TRPV2 TRPV3 TRPV1 TRPV6 TRPV4 TRPV5 CALM1 TRDN STOML3 ANO10 SLC17A3 CLCN3 WWP1 CLCN2 OSTM1 BEST2 CLCN1 SLC9C1 BEST3 UBA52 STOM SLC9C2 BEST1 BEST4 CLCN7 CLCN6 CLCN5 CLCN4 UBB UBC RPS27A SLC9B1 SLC9B2 CLCA2 CLCA1 CLCA4 UNC80 TRPC5 TRPC4 TRPC1 ASPH BSND MCOLN3 TRPA1 CLCA3P MCOLN1 MCOLN2 TPCN2 TPCN1 UNC79 WNK4 TRPM1 TRPM2 TRPM7 TRPM8 TRPM5 TRPM6 TRPM3 TRPM4 WNK1 WNK2 WNK3 RYR1 RYR2 RYR3 CLIC2 RAF1 TSC22D3 ANO8 ANO9 ANO6 ANO7 ANO4 ANO5 ANO2 ANO3 ANO1 SGK3 SGK2 THE NLRP1 INFLAMMASOME%REACTOME DATABASE ID RELEASE 76%844455 The NLRP1 inflammasome NLRP1 BCL2 BCL2L1 RHO GTPASES ACTIVATE PKNS%REACTOME DATABASE ID RELEASE 76%5625740 RHO GTPases activate PKNs AR RHOC MYL12B RHOB YWHAQ SFN YWHAH H2AX H2AB1 H2AC19 KDM1A H2AC14 H2BC21 PKN3 YWHAE H2BU1 H3-3B PDPK1 H3C8 H2AC8 PPP1CB H2AC6 MYH9 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 PAK1 YWHAG KDM4C PKN2 H2BC11 PPP1R12A PKN1 CDC25C MYL6 MYH14 MYH11 MYL9 MYH10 H3C15 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 YWHAB H2BC3 H2BC1 PPP1R12B H2AC20 YWHAZ NCOA2 PPP1R14A RAC1 KLK3 RHOA KLK2 STAT5 ACTIVATION%REACTOME DATABASE ID RELEASE 76%9645135 STAT5 Activation STAT5A STAT5B FLT3LG GAB2 FLT3 PTPN11 ROLE OF ABL IN ROBO-SLIT SIGNALING%REACTOME DATABASE ID RELEASE 76%428890 Role of ABL in ROBO-SLIT signaling ROBO1 CAP1 ABL1 ABL2 CLASP1 SLIT2 CAP2 CLASP2 ARYL HYDROCARBON RECEPTOR SIGNALLING%REACTOME%R-HSA-8937144.2 Aryl hydrocarbon receptor signalling PTGES3 ARNT2 AHR ARNT AHRR AIP HSP90AB1 METAL SEQUESTRATION BY ANTIMICROBIAL PROTEINS%REACTOME DATABASE ID RELEASE 76%6799990 Metal sequestration by antimicrobial proteins S100A9 S100A8 LCN2 S100A7A LTF S100A7 SYNTHESIS OF PROSTAGLANDINS (PG) AND THROMBOXANES (TX)%REACTOME DATABASE ID RELEASE 76%2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) PTGS2 PTGES3 PTGIS TBXAS1 HPGDS CBR1 AKR1C3 PTGS1 PTGES HPGD PTGR2 PTGDS CYP8B1 PTGES2 PRXL2B RNA POLYMERASE II TRANSCRIPTION TERMINATION%REACTOME%R-HSA-73856.4 RNA Polymerase II Transcription Termination CSTF2 PABPN1 PAPOLA CPSF1 CPSF4 EIF4A3 SNRPG CASC3 LSM10 LSM11 MAGOH SNRPE THOC1 SNRPF THOC3 THOC2 THOC5 CDC40 THOC7 SNRPB THOC6 DDX39A DDX39B ZC3H11A CPSF3 SARNP CPSF2 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SLU7 SRSF9 FYTTD1 LUZP4 RBM8A POLDIP3 SRSF1 U2AF1 U2AF1L4 U2AF2 DHX38 SRSF11 CHTOP ALYREF UPF3B MAGOHB RNPS1 CSTF2T FIP1L1 CPSF7 SRRM1 SNRPD3 ZNF473 SLBP CSTF3 NCBP1 NCBP2 CSTF1 SYMPK PCF11 WDR33 NUDT21 CLP1 MECP2 REGULATES TRANSCRIPTION FACTORS%REACTOME DATABASE ID RELEASE 76%9022707 MECP2 regulates transcription factors PPARG MEF2C RBFOX1 CREB1 NICOTINATE METABOLISM%REACTOME%R-HSA-196807.3 Nicotinate metabolism NNMT NAMPT QPRT NADK2 NAXE NMRK2 NMRK1 RNLS SLC22A13 CD38 NAXD NUDT12 PARP10 PARP6 PARP4 PARP16 NMNAT3 PARP9 BST1 NMNAT2 PARP14 NMNAT1 PARP8 NAPRT PTGS2 NT5E PTGIS CYP8B1 SLC5A8 NADSYN1 NADK AXONAL GROWTH INHIBITION (RHOA ACTIVATION)%REACTOME%R-HSA-193634.2 Axonal growth inhibition (RHOA activation) OMG MAG MCF2 ARHGDIA RHOA LINGO1 RTN4 NGFR NADE MODULATES DEATH SIGNALLING%REACTOME%R-HSA-205025.1 NADE modulates death signalling CASP2 NGF YWHAE BEX3 CASP3 NGFR DISEASES OF THE NEURONAL SYSTEM%REACTOME%R-HSA-9675143.2 Diseases of the neuronal system TTR ABCA4 OPN1LW LRAT OPN1MW RBP4 NAPEPLD STRA6 RBP1 RLBP1 RDH5 OPN1SW RDH12 DEFECTIVE SLCO1B3 CAUSES HYPERBILIRUBINEMIA, ROTOR TYPE (HBLRR)%REACTOME%R-HSA-5619058.2 Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR) SLCO1B3 REGULATION OF ORNITHINE DECARBOXYLASE (ODC)%REACTOME%R-HSA-350562.2 Regulation of ornithine decarboxylase (ODC) ODC1 NQO1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 AZIN1 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 OAZ1 PSMB3 OAZ2 PSMB1 PSMF1 OAZ3 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 VIRION ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 76%9679509 Virion Assembly and Release 7a N 3a M E S DNA REPAIR%REACTOME%R-HSA-73894.3 DNA Repair KPNA2 FTO ALKBH2 ALKBH5 YY1 MSH3 CETN2 PPP4R2 TIPIN TIMELESS PPP4C POLQ POLH ABL1 UBXN1 UBA52 UBB RTEL1 MSH6 RUVBL1 UBC POLK NFRKB RPS27A POLE RNF111 LIG1 PARP1 RFC1 PARP2 ACTR5 USP45 ACTL6A LIG3 RAD23A ACTR8 CHD1L RAD23B UBE2V2 INO80C LIG4 INO80B INO80E SIRT6 INO80D XPC RAD51B PIAS4 POLD3 RAD51C PIAS3 TFPT UBE2I POLD4 POLD1 POLD2 ELL MCRS1 RNF4 XRCC1 RCHY1 INO80 POLE4 ERCC4 PCLAF ERCC1 PIAS1 USP43 POLE2 POLE3 ERCC5 SUMO1 SUMO3 SUMO2 CCNH POLR2A MPG POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L GTF2H1 GTF2H2 ACTB H2AC14 GTF2H3 UBA7 H2BC21 GTF2H4 EP300 H2BU1 GTF2H5 CDK7 UBE2L6 H2AC8 ERCC3 ERCC2 H2AC6 MNAT1 H2AC7 BAZ1B H2BC17 H2BC12 ISG15 H2BC13 CHEK1 H2BC14 H2AJ CENPX H2BC15 H2BC11 PAXIP1 H2BS1 VCP PRKDC H2AZ1 H2BC9 XRCC6 H2AZ2 H4C9 XRCC5 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 H2AC20 ERCC6 TRIM25 ISY1 PRPF19 HMGN1 USP7 AQR DDB1 PPIE ZNF830 ALKBH3 XPA MRE11 COPS7B ASCC1 COPS7A ASCC2 ASCC3 CUL4A COPS3 KAT5 XAB2 COPS6 COPS5 NBN UVSSA ERCC8 TCEA1 COPS8 HUS1 CUL4B FEN1 DNA2 RHNO1 BLM USP1 UBE2B BRIP1 DTL RAD18 ATRIP BRCC3 BARD1 RAD17 RAD9B BAP1 ATR WDR48 RAD9A BABAM1 BABAM2 BRCA1 UIMC1 UFD1 EXO1 TOPBP1 UBE2T RFC5 RMI2 RFC3 RFC4 RFC2 OGG1 RMI1 NTHL1 TOP3A TDG MBD4 ACD TINF2 WRN TERF1 TERF2 RBBP8 SMUG1 NEIL3 NEIL2 RPA1 H3-4 POT1 RPA2 TERF2IP NEIL1 RAD50 RPA3 MAPK8 RAD1 CENPS CLSPN MGMT HERC2 POLB TP53BP1 XRCC4 USP10 RNF168 ABRAXAS1 PNKP RAD52 BRCA2 RAD51AP1 XRCC2 XRCC3 NPLOC4 SPRTN PALB2 RAD51D RAD51 MDC1 CHEK2 FAAP100 REV1 NHEJ1 MAD2L2 CCNA2 TDP2 REV3L CCNA1 TDP1 FAAP24 TP53 FAAP20 DCLRE1B DCLRE1A DCLRE1C RIF1 CDK2 FANCM ATM FANCL FANCA FANCB FANCE FANCG FANCF DDB2 POLL PCNA RBX1 FAN1 POLN POLM PMS2 MLH1 RNF8 NSD2 APBB1 KDM4A MSH2 MUS81 KDM4B SLX4 FANCD2 EYA1 EME1 EYA2 EME2 EYA3 GEN1 EYA4 PPP5C SLX1B SPIDR FANCI FANCC PARG APEX1 ADPRS GPS1 COPS4 COPS2 POLI UBE2N SIGNALING BY ERBB4%REACTOME%R-HSA-1236394.4 Signaling by ERBB4 PSEN1 GABRB3 GABRB2 GABRB1 NCSTN ESR1 SHC1 GABRG3 CXCL12 GABRG2 PIK3CA GABRQ SOS1 GABRA1 PGR DLG4 PSEN2 NEDD4 APH1A APH1B PIK3R1 CSN2 STMN1 ADAP1 ITCH MXD4 PSENEN NRG1 NRG2 NRG3 NRG4 WWP1 EGF UBA52 HBEGF APOE EGFR UBB STAT5A HRAS UBC RPS27A NRAS GFAP NCOR1 SPARC WWOX ADAM17 EREG BTC YAP1 S100B SRC TAB2 ERYTHROCYTES TAKE UP OXYGEN AND RELEASE CARBON DIOXIDE%REACTOME%R-HSA-1247673.1 Erythrocytes take up oxygen and release carbon dioxide RHAG HBB HBA2 CA1 CA2 CA4 SLC4A1 AQP1 NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-112310.5 Neurotransmitter release cycle SYT1 ABAT ARL6IP5 GAD1 GAD2 CASK LIN7A SYN1 LIN7C LIN7B SLC1A2 SLC1A6 SLC1A7 UNC13B HSPA8 APBA1 SYN3 CPLX1 SYN2 RIMS1 ALDH5A1 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 PPFIA2 SLC6A1 SLC18A3 NAAA SLC18A2 SLC6A13 CHAT GLS SLC5A7 SLC6A12 VAMP2 SLC6A11 SLC1A1 SLC1A3 MAOA SNAP25 RAB3A SLC32A1 DNAJC5 SLC22A2 SLC22A1 SLC38A2 SLC17A7 GLS2 ALKBH2 MEDIATED REVERSAL OF ALKYLATION DAMAGE%REACTOME DATABASE ID RELEASE 76%112122 ALKBH2 mediated reversal of alkylation damage ALKBH2 DEFECTIVE MOGS CAUSES MOGS-CDG (CDG-2B)%REACTOME%R-HSA-4793954.1 Defective MOGS causes MOGS-CDG (CDG-2b) MOGS BIOSYNTHESIS OF DPAN-3-DERIVED 13-SERIES RESOLVINS%REACTOME DATABASE ID RELEASE 76%9026403 Biosynthesis of DPAn-3-derived 13-series resolvins ALOX5 ERYTHROPOIETIN ACTIVATES STAT5%REACTOME DATABASE ID RELEASE 76%9027283 Erythropoietin activates STAT5 STAT5A STAT5B JAK2 EPOR IRS2 LYN EPO DEFECTIVE MMADHC CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLD%REACTOME DATABASE ID RELEASE 76%3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD MMACHC MMADHC DEFECTIVE SLC36A2 CAUSES IMINOGLYCINURIA (IG) AND HYPERGLYCINURIA (HG)%REACTOME DATABASE ID RELEASE 76%5619041 Defective SLC36A2 causes iminoglycinuria (IG) and hyperglycinuria (HG) SLC36A2 FANCONI ANEMIA PATHWAY%REACTOME%R-HSA-6783310.3 Fanconi Anemia Pathway CENPS FAAP24 FAAP20 USP1 DCLRE1B DCLRE1A ERCC4 ERCC1 FANCM ATRIP FANCL FANCA FANCB FANCE FANCG FANCF FAN1 POLN UBA52 ATR WDR48 UBB UBE2T UBC MUS81 SLX4 FANCD2 EME1 RPS27A EME2 SLX1B FANCI RPA1 RPA2 FANCC CENPX RPA3 FAAP100 TYSND1 CLEAVES PEROXISOMAL PROTEINS%REACTOME DATABASE ID RELEASE 76%9033500 TYSND1 cleaves peroxisomal proteins TYSND1 SCP2 ACAA1 PHYH HSD17B4 ACOX1 AGPS REGULATION OF KIT SIGNALING%REACTOME%R-HSA-1433559.1 Regulation of KIT signaling SOCS6 PRKCA SH2B3 SOS1 SH2B2 LCK KIT FYN SOCS1 PTPN6 CBL LYN YES1 DEFECTIVE ABCG5 CAUSES SITOSTEROLEMIA%REACTOME%R-HSA-5679096.1 Defective ABCG5 causes sitosterolemia ABCG8 ABCG5 MAP KINASE ACTIVATION%REACTOME%R-HSA-450294.3 MAP kinase activation TAB1 UBE2V1 PPP2R1B MAP2K6 FOS PPP2R5D MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 PPP2CA PPP2CB PPP2R1A BTRC NFKB1 SKP1 MAPK8 FBXW11 UBA52 MAP2K1 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 CHUK MAPKAPK2 UBC JUN TNIP2 RPS27A IKBKG MAPK9 MAPK10 CREB1 NOD1 NOD2 MAPK14 MAPK11 IRAK1 IRAK2 ATF2 RIPK2 TRAF6 UBE2N TAB3 MAP3K7 TAB2 CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION%REACTOME%R-HSA-69202.3 Cyclin E associated events during G1 S transition CCNA1 CCNE2 CCNE1 CDK2 CABLES1 WEE1 CCNH MAX E2F5 SKP2 CDK7 MNAT1 CDC25A SKP1 CKS1B PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 RBBP4 PSMA6 PSMA3 LIN54 RBL2 PSMA4 PSMA1 PSMA2 LIN52 PSME3 PSME1 PSME2 E2F4 UBA52 PSMD10 LIN37 PSMD12 LIN9 PSMD11 PSMD14 PSMD13 AKT2 PSMA7 PSMB10 CUL1 AKT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB RB1 PSMB3 PSMB1 TFDP1 PSMF1 UBC PSMB8 TFDP2 PSMB9 CCND1 RPS27A SEM1 PSMC5 CDK4 E2F1 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PTK6 MYC CDKN1A CDKN1B AKT3 CCNA2 RETROGRADE NEUROTROPHIN SIGNALLING%REACTOME DATABASE ID RELEASE 76%177504 Retrograde neurotrophin signalling DNM2 AP2B1 NGF DNM3 SH3GL2 CLTA CLTC AP2A1 AP2A2 AP2S1 DNAL4 AP2M1 NTRK1 DNM1 CREB3 FACTORS ACTIVATE GENES%REACTOME DATABASE ID RELEASE 76%8874211 CREB3 factors activate genes CREBRF DCSTAMP MBTPS2 CREB3L3 CREB3 CREB3L4 MBTPS1 CREB3L1 CREB3L2 SIGNALING BY NOTCH1 PEST DOMAIN MUTANTS IN CANCER%REACTOME DATABASE ID RELEASE 76%2644602 Signaling by NOTCH1 PEST Domain Mutants in Cancer HDAC3 PSEN1 CREBBP HES1 JAG2 NCSTN HEY1 SNW1 HEY2 MAMLD1 RBX1 NEURL1B MIB2 MIB1 HEYL EP300 PSEN2 CDK8 APH1A APH1B KAT2B KAT2A HDAC5 HDAC8 HDAC9 SKP1 DLL1 HDAC7 DLL4 HES5 HDAC2 PSENEN HDAC1 HDAC6 NEURL1 JAG1 UBA52 CUL1 UBB UBC RPS27A TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 CCNC ADAM10 ADAM17 MAML3 HDAC4 NOTCH1 DETOXIFICATION OF REACTIVE OXYGEN SPECIES%REACTOME%R-HSA-3299685.5 Detoxification of Reactive Oxygen Species NOX4 TXNRD1 GPX2 GPX1 NCF1 NCF2 NCF4 ATP7A ERO1A ATOX1 NUDT2 PRDX3 PRDX6 NOX5 GPX3 GPX6 GPX5 SOD2 P4HB GPX8 PRDX2 GPX7 PRDX1 GSTP1 TXNRD2 CYBB SOD3 CYBA SOD1 CCS TXN2 CAT AQP8 TXN CYCS POST NMDA RECEPTOR ACTIVATION EVENTS%REACTOME DATABASE ID RELEASE 76%438064 Post NMDA receptor activation events KPNA2 PRKACG PRKACB CAMK1 ACTN2 PRKAR1B CAMKK1 RASGRF2 CAMKK2 RASGRF1 PRKAR1A NRGN GRIN2B RPS6KA6 MAPK1 GRIN1 RPS6KA3 GRIN2D GRIA2 DLG1 RPS6KA2 PRKAR2A DLG2 RPS6KA1 DLG3 LRRC7 MAPK3 DLG4 NEFL GRIN2A PRKX GRIN2C PRKAB2 PRKAA2 PRKAG1 PDPK1 PRKAG2 PRKAB1 PRKAG3 ADCY1 ADCY8 PRKACA CALM1 GIT1 NRG1 PRKAA1 CAMK2B PRKAR2B HRAS CAMK2D CAMK2A CAMK2G NRAS CREB1 RAC1 CAMK4 GRIA1 SRC MET RECEPTOR RECYCLING%REACTOME DATABASE ID RELEASE 76%8875656 MET receptor recycling RAB4B CRKL HGF ARF6 MET CRK RAB4A GAB1 GGA3 NEF MEDIATED CD8 DOWN-REGULATION%REACTOME DATABASE ID RELEASE 76%182218 Nef Mediated CD8 Down-regulation AP2A1 AP2B1 AP2A2 AP2S1 ATP6V1H AP2M1 nef CD8B PROCESSING OF CAPPED INTRONLESS PRE-MRNA%REACTOME%R-HSA-75067.2 Processing of Capped Intronless Pre-mRNA CSTF2T FIP1L1 CSTF2 PABPN1 PAPOLA CPSF1 CPSF4 CPSF7 SNRPG LSM10 LSM11 SNRPE SNRPF SNRPD3 ZNF473 SNRPB SLBP CSTF3 CPSF3 NCBP1 CPSF2 NCBP2 CSTF1 SYMPK PCF11 WDR33 NUDT21 CLP1 TWIK RELATED POTASSIUM CHANNEL (TREK)%REACTOME DATABASE ID RELEASE 76%1299503 TWIK related potassium channel (TREK) KCNK2 KCNK4 KCNK10 HIV LIFE CYCLE%REACTOME DATABASE ID RELEASE 76%162587 HIV Life Cycle NUP42 VTA1 rev NUP43 gag-pol RAE1 vif RANBP2 NMT2 vpr vpu RAN NUP35 CHMP2B NUP37 CHMP2A NEDD4L env KPNA1 CD4 CHMP3 VPS37C VPS37D VPS37A CHMP6 VPS37B CHMP7 CHMP5 VPS4B VPS4A MVB12B MVB12A XRCC4 UBA52 XPO1 RANGAP1 NCBP1 NUP214 NCBP2 UBB UBC RPS27A LIG1 CCNK CCR5 LIG4 CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP nef NELFE SUPT16H GTF2A1 ELOA3P VPS28 tat GTF2A2 GTF2B ELOA2 TAF9 SSRP1 CDK9 TAF1L CCNH GTF2E1 GTF2E2 RNMT TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 HMGA1 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 CCNT2 TAF4B PDCD6IP POLR2I POLR2J TAF6 POLR2K TAF5 CXCR4 POLR2L TAF4 RNGTT TAF3 GTF2H1 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 RCC1 TBP ERCC2 MNAT1 SEC13 NUP107 NUP188 FURIN BANF1 NUP210 NUP93 PPIA POM121 PSIP1 NUP205 XRCC6 AAAS XRCC5 NUP160 POM121C NUP85 TPR NUP88 NUP155 NUP153 UBAP1 CHMP4C CHMP4B CHMP4A NMT1 NUP62 gag NDC1 TSG101 NUP133 RANBP1 TCEA1 NUP50 FEN1 NUP54 RMTS METHYLATE HISTONE ARGININES%REACTOME DATABASE ID RELEASE 76%3214858 RMTs methylate histone arginines H2AC17 H2AC12 H3C15 WDR5 ACTL6B RBBP7 PBRM1 PRMT1 H2AZ1 H2AC21 H2AZ2 ARID1A H2AW H4C9 ARID1B SMARCD1 PRMT7 SMARCD2 PRMT3 SMARCB1 ARID2 H2AX WDR77 H2AB1 SMARCE1 H2AC20 H2AC19 PRMT5 SMARCC1 SMARCC2 H2AC14 SMARCD3 CCND1 CDK4 H3C8 H2AC8 H2AC6 CARM1 H2AC7 ACTL6A JAK2 PRMT6 H2AJ COPRS H2AC1 RPS2 SMARCA2 SMARCA4 SIGNALLING TO ERKS%REACTOME DATABASE ID RELEASE 76%187687 Signalling to ERKs NGF BRAF SHC1 CRK SOS1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 SHC3 MAPK12 CRKL MAPK13 MAPKAPK3 HRAS MAPKAPK2 NRAS RAP1A KIDINS220 SHC2 FRS2 MAPK14 RAPGEF1 RALGDS MAPK11 RALA RALB RIT1 RIT2 NTRK1 PRE-NOTCH TRANSCRIPTION AND TRANSLATION%REACTOME DATABASE ID RELEASE 76%1912408 Pre-NOTCH Transcription and Translation CREBBP TP53 RUNX1 SNW1 MAMLD1 AGO3 AGO4 AGO1 AGO2 H2AX PRKCI H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 KAT2B H2BC14 H2AJ KAT2A H2BC15 H2BC11 H3C15 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 NOTCH2 H2BC5 NOTCH3 H2BC3 NOTCH4 H2BC1 H2AC20 TFDP1 JUN TFDP2 CCND1 E2F1 E2F3 MAML2 TNRC6C MAML1 MOV10 RBPJ TNRC6A TNRC6B SIRT6 MAML3 ELF3 NOTCH1 CONSTITUTIVE SIGNALING BY EGFRVIII%REACTOME DATABASE ID RELEASE 76%5637810 Constitutive Signaling by EGFRvIII HSP90AA1 CDC37 HRAS SHC1 GAB1 PIK3CA PLCG1 SOS1 EGF NRAS PIK3R1 EGFR CBL AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1%REACTOME%R-HSA-349425.2 Autodegradation of the E3 ubiquitin ligase COP1 TP53 COP1 ATM PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SEPARATION OF SISTER CHROMATIDS%REACTOME DATABASE ID RELEASE 76%2467813 Separation of Sister Chromatids PPP2R1B PPP2R5E NUP43 RANBP2 PPP2R5B CDCA8 PPP2R5A SKA1 PPP2R5D SKA2 PPP2R5C NUP37 NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU PPP2R1A CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN DYNLL2 CENPO CENPP CENPQ CENPS SMC3 DYNLL1 CKAP5 CLIP1 RAD21 KIF18A MAD1L1 MAPRE1 NDC80 STAG1 UBA52 STAG2 PAFAH1B1 SMC1A DYNC1I2 SPDL1 XPO1 CENPF RANGAP1 UBB NSL1 CDC20 UBC ESPL1 RPS27A PTTG1 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 RCC2 ZWINT AHCTF1 ZW10 NDEL1 KIF2A KIF2C MIS12 KIF2B RPS27 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L CENPE ZWILCH KNTC1 SGO1 SGO2 PMF1 BUB1B ANAPC15 BUB3 ANAPC16 SEC13 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 BUB1 NUP107 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DYNC1I1 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 BIRC5 PSME1 PSME2 PSMD10 ITGB3BP PSMB11 PSMD12 PSMD11 NUP160 PSMD14 PSMD13 NUP85 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDCA5 NUP133 PDS5B PDS5A WAPL DEFECTIVE MAN1B1 CAUSES MRT15%REACTOME%R-HSA-4793950.2 Defective MAN1B1 causes MRT15 MAN1B1 ER TO GOLGI ANTEROGRADE TRANSPORT%REACTOME%R-HSA-199977.4 ER to Golgi Anterograde Transport COL7A1 TRAPPC2 ANKRD28 TRAPPC3 SEC16B F8 TRAPPC1 TRAPPC4 SEC16A TRAPPC5 TMEM115 COPE TRAPPC9 CNIH1 CNIH2 CNIH3 MCFD2 TRAPPC6A PPP6C PPP6R1 TRAPPC6B PPP6R3 GORASP1 ACTR1A ARFGAP3 SPTB DCTN6 ARFGAP1 DCTN5 BET1L ARFGAP2 DCTN1 GOSR2 SEC22B DCTN4 SEC22A GOSR1 SPTAN1 SEC22C DYNLL2 RAB1A SPTBN1 SEC23A INS RAB1B LMAN1 CSNK1D DYNLL1 YKT6 SEC24B SEC24A DYNC1I2 DCTN2 SEC24D DCTN3 SEC24C FOLR1 BET1 KDELR1 GOLGA2 CAPZB COG8 COG7 COG6 DYNC1H1 LMAN1L COG5 COG4 COG3 COG2 COG1 ANK2 ANK3 ANK1 TFG PREB KDELR2 KDELR3 SPTBN4 SPTBN5 LMAN2L TGFA SCFD1 DYNC1LI1 DYNC1LI2 SEC31A SPTBN2 CAPZA1 CAPZA2 CTSZ MIA2 MIA3 ARF3 TMED3 TMED2 ARF4 TMED7 ARF1 CTSC SERPINA1 SEC13 TMED9 AREG NAPA NAPB STX17 COPZ2 NAPG COPZ1 CD59 DYNC1I1 CD55 GBF1 SEC23IP SAR1B CAPZA3 ARF5 F5 COPG2 COPG1 USO1 ACTR10 LMAN2 STX5 TRAPPC10 ARCN1 NSF TRAPPC2L TBC1D20 COPB2 COPA TMED10 GRIA1 COPB1 SPTA1 RAF-INDEPENDENT MAPK1 3 ACTIVATION%REACTOME%R-HSA-112409.2 RAF-independent MAPK1 3 activation DUSP6 DUSP7 DUSP16 PTPN11 TYK2 DUSP8 PEA15 DUSP5 DUSP9 DUSP10 DUSP2 DUSP1 JAK2 MAP2K1 MAP2K2 MAPK1 IL6R CDK1 MAPK3 JAK1 DUSP4 IL6 DNA DAMAGE REVERSAL%REACTOME DATABASE ID RELEASE 76%73942 DNA Damage Reversal ALKBH3 ASCC1 ASCC2 ASCC3 MGMT FTO ALKBH2 ALKBH5 CARGO RECOGNITION FOR CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME DATABASE ID RELEASE 76%8856825 Cargo recognition for clathrin-mediated endocytosis SYT2 SYT1 TOR1A SYT9 SYT8 IGF2R M6PR TFRC TOR1B DAB2 SLC2A8 AAK1 EPN1 CD4 ARRB1 EPN2 ARRB2 HGS APOB AVPR2 SGIP1 CLTC AGTR1 VAMP3 CBL LRP2 REPS2 FCHO1 FCHO2 REPS1 UBQLN1 UBQLN2 EGF NECAP2 UBA52 NECAP1 SYT11 UBB UBC RPS27A AGFG1 PICALM ITSN2 ITSN1 EREG BTC CFTR TACR1 TGFA TGOLN2 AVP STAM SNAP91 TF FZD4 SH3KBP1 CD3G CD3D CLTA AP2A1 CLTB STON1 STON2 AP2A2 AREG SLC18A3 LDLRAP1 AP2M1 NEDD8 EPS15L1 VAMP8 EPS15 VAMP7 CHRM2 VAMP4 EPGN VAMP2 GPS1 HBEGF COPS4 COPS2 AP2S1 EGFR LDLR SCARB2 SH3GL3 AP2B1 SH3GL2 SH3GL1 ADRB2 WNT5A STAM2 COPS7B COPS7A COPS3 COPS6 COPS5 GRK3 GRK2 CLTCL1 COPS8 DVL2 KIAA0319 PROCESSING OF DNA DOUBLE-STRAND BREAK ENDS%REACTOME%R-HSA-5693607.1 Processing of DNA double-strand break ends CCNA1 RHNO1 RNF4 BLM BRIP1 CDK2 ATRIP ATM SUMO1 BRCC3 BARD1 SUMO2 RAD17 RAD9B ATR RAD9A BABAM1 BABAM2 BRCA1 UIMC1 H2AX EXO1 TOPBP1 RFC5 RNF8 RMI2 NSD2 RFC3 H2BC21 RFC4 RFC2 H2BU1 RMI1 TOP3A WRN RBBP8 H2BC17 H2BC12 H2BC13 RPA1 H3-4 CHEK1 H2BC14 RPA2 H2BC15 RAD50 PPP4R2 TIPIN RPA3 H2BC11 TIMELESS PPP4C RAD1 CLSPN HERC2 H2BS1 TP53BP1 H2BC9 UBA52 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 RNF168 ABRAXAS1 UBB UBC RPS27A MRE11 MDC1 KAT5 UBE2V2 NBN SIRT6 PIAS4 HUS1 UBE2N UBE2I CCNA2 DNA2 INTERLEUKIN-6 SIGNALING%REACTOME DATABASE ID RELEASE 76%1059683 Interleukin-6 signaling STAT1 JAK2 STAT3 IL6R IL6ST CBL JAK1 PTPN11 SOCS3 IL6 TYK2 TRYPTOPHAN CATABOLISM%REACTOME%R-HSA-71240.2 Tryptophan catabolism SLC3A2 KYAT1 KYNU AADAT ACMSD TDO2 AFMID SLC36A4 SLC7A5 IDO2 IDO1 HAAO KMO KYAT3 METABOLISM OF NITRIC OXIDE: NOS3 ACTIVATION AND REGULATION%REACTOME DATABASE ID RELEASE 76%202131 Metabolism of nitric oxide: NOS3 activation and regulation DNM2 HSP90AA1 NOS3 CYGB CAV1 WASL LYPLA1 SPR CALM1 NOSIP DDAH1 DDAH2 NOSTRIN ZDHHC21 AKT1 FIBRONECTIN MATRIX FORMATION%REACTOME DATABASE ID RELEASE 76%1566977 Fibronectin matrix formation FN1 CEACAM1 ITGA5 CEACAM6 CEACAM8 ITGB1 STABILIZATION OF P53%REACTOME DATABASE ID RELEASE 76%69541 Stabilization of p53 TP53 COP1 CDKN2A MDM2 ATM MDM4 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PHF20 CHEK2 SIGNALING BY AXIN MUTANTS%REACTOME DATABASE ID RELEASE 76%4839735 Signaling by AXIN mutants PPP2CA PPP2CB APC PPP2R1B PPP2R5E PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%390471 Association of TriC CCT with target proteins during biosynthesis HDAC3 CCNE2 CCNE1 USP11 DCAF7 TP53 GBA CCT6B AP3M1 FBXO4 LONP2 FBXO6 CCT2 FBXW4 FBXW5 FBXW10 CCT8 FBXW7 CCT5 FBXW9 CCT4 NOP56 ARFGEF2 FBXW2 STAT3 XRN2 GAPDHS FKBP9 CCT7 CCT6A SKIV2L FBXL3 FBXL5 WRAP53 KIF13A CCT3 SPHK1 TCP1 CLATHRIN-MEDIATED ENDOCYTOSIS%REACTOME%R-HSA-8856828.3 Clathrin-mediated endocytosis PACSIN1 SYT2 SYT1 TOR1A SYT9 SYT8 IGF2R M6PR ARPC4 TFRC SYNJ2 ARPC5 TOR1B DAB2 SLC2A8 SYNJ1 ARPC2 ARPC3 AAK1 EPN1 DNM1 DNM2 CD4 ARRB1 EPN2 ARRB2 DNM3 PIK3C2A HSPA8 HGS APOB RAB5A AVPR2 ACTR2 OCRL SGIP1 CLTC WASL AGTR1 ARFGAP1 VAMP3 DNAJC6 CBL LRP2 REPS2 FCHO1 FCHO2 REPS1 UBQLN1 UBQLN2 EGF HIP1R NECAP2 UBA52 NECAP1 SYT11 UBB UBC RPS27A AGFG1 PICALM ITSN2 ITSN1 FNBP1L EREG BTC CFTR TACR1 FNBP1 TGFA TGOLN2 GAPVD1 BIN1 SNX9 AVP STAM SNAP91 PIP5K1C TF FZD4 HIP1 SH3KBP1 CD3G CD3D CLTA ARPC1A AP2A1 CLTB STON1 STON2 AP2A2 GAK CTTN AREG SLC18A3 LDLRAP1 AP2M1 NEDD8 EPS15L1 VAMP8 EPS15 VAMP7 CHRM2 VAMP4 EPGN VAMP2 TRIP10 GPS1 HBEGF COPS4 ARF6 COPS2 AP2S1 EGFR LDLR SCARB2 SH3GL3 AP2B1 SH3GL2 SH3GL1 SNX18 ADRB2 WNT5A AMPH STAM2 COPS7B COPS7A COPS3 COPS6 RAB5B COPS5 RAB5C GRK3 GRK2 CLTCL1 PACSIN2 COPS8 DVL2 PACSIN3 KIAA0319 MAPK3 (ERK1) ACTIVATION%REACTOME DATABASE ID RELEASE 76%110056 MAPK3 (ERK1) activation JAK2 MAP2K1 IL6R CDK1 MAPK3 JAK1 PTPN11 IL6 TYK2 GABA SYNTHESIS%REACTOME DATABASE ID RELEASE 76%888568 GABA synthesis GAD1 GAD2 TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION%REACTOME%R-HSA-381340.2 Transcriptional regulation of white adipocyte differentiation HDAC3 CREBBP RXRA SREBF2 PPARG PPARGC1A PPARA LEP SLC2A4 CD36 TNF MED30 MED31 EP300 CDK8 CEBPB CEBPA NR2F2 PCK1 MED19 KLF4 NFKB1 KLF5 MED18 MED11 MED8 MED16 MED15 MED4 MED29 MED17 MED6 MED28 MED12 MED7 MED22 MED14 MED21 MED13 ZNF467 MED10 ADIPOQ ZNF638 WNT1 ANGPTL4 EGR2 MED27 MED13L MED26 NCOA3 MED23 MED25 MED24 LPL MED20 MED9 NCOA1 CCND3 MED1 NCOA2 WNT10B CDK19 SMARCD3 RELA CHD9 NCOA6 CDK4 HELZ2 TBL1XR1 NCOR2 TGS1 CARM1 TBL1X CEBPD NCOR1 EBF1 ADIRF TGFB1 CCNC FABP4 THRAP3 FAM120B PLIN1 MITOCHONDRIAL FATTY ACID BETA-OXIDATION OF SATURATED FATTY ACIDS%REACTOME DATABASE ID RELEASE 76%77286 mitochondrial fatty acid beta-oxidation of saturated fatty acids HADHB HADH HADHA ACADL MECR ECHS1 ACADM ACADVL ACADS ACSM3 ACSM6 CROSSLINKING OF COLLAGEN FIBRILS%REACTOME%R-HSA-2243919.3 Crosslinking of collagen fibrils PXDN TLL2 BMP1 LOXL3 TLL1 LOXL4 LOXL1 LOXL2 PCOLCE LOX SYNTHESIS OF DOLICHYL-PHOSPHATE-GLUCOSE%REACTOME%R-HSA-480985.2 Synthesis of dolichyl-phosphate-glucose NUDT14 ALG5 DISEASES OF BASE EXCISION REPAIR%REACTOME DATABASE ID RELEASE 76%9605308 Diseases of Base Excision Repair NEIL3 NEIL1 OGG1 NTHL1 HEDGEHOG 'ON' STATE%REACTOME%R-HSA-5632684.1 Hedgehog 'on' state SPOP EVC2 SHH DHH IHH SMURF2 RBX1 SMO GPR161 KIF3A PTCH1 ARRB1 GLI1 ARRB2 GLI3 GLI2 SUFU KIF7 NUMB CDON CSNK1A1 ITCH PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 SMURF1 HHIP ULK3 DZIP1 EFCAB7 GRK2 BOC IQCE CDC73 EVC GAS1 SPOPL GAS8 REGULATION OF APC C ACTIVATORS BETWEEN G1 S AND EARLY ANAPHASE%REACTOME DATABASE ID RELEASE 76%176408 Regulation of APC C activators between G1 S and early anaphase CCNA1 CDK2 FZR1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 BTRC ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 SKP1 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 FBXO5 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 CCNB1 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PLK1 CDK1 CCNA2 FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC%REACTOME DATABASE ID RELEASE 76%389960 Formation of tubulin folding intermediates by CCT TriC TUBAL3 CCT6B TUBB6 TUBA3E TUBB3 TUBB1 TUBA3D TUBA3C CCT2 TUBA4A CCT8 CCT5 CCT4 TUBA4B CCT7 CCT6A TUBA1A TUBA8 TUBA1C TUBB4B TUBA1B TUBB4A CCT3 TUBB2B TUBB2A TCP1 TOXICITY OF BOTULINUM TOXIN TYPE C (BOTC)%REACTOME%R-HSA-5250971.2 Toxicity of botulinum toxin type C (botC) SNAP25 STX1B STX1A RESOLUTION OF AP SITES VIA THE MULTIPLE-NUCLEOTIDE PATCH REPLACEMENT PATHWAY%REACTOME%R-HSA-110373.2 Resolution of AP sites via the multiple-nucleotide patch replacement pathway POLD2 POLE4 POLE2 POLE3 POLB PCNA RFC5 RFC3 RFC4 RFC2 POLE LIG1 PARP1 RFC1 PARP2 RPA1 RPA2 PARG APEX1 RPA3 ADPRS POLD3 FEN1 POLD4 POLD1 FORMATION OF THE EDITOSOME%REACTOME%R-HSA-75094.2 Formation of the Editosome APOBEC1 APOBEC3C APOBEC2 APOBEC4 APOBEC3H A1CF APOBEC3A APOBEC3B ZINC EFFLUX AND COMPARTMENTALIZATION BY THE SLC30 FAMILY%REACTOME DATABASE ID RELEASE 76%435368 Zinc efflux and compartmentalization by the SLC30 family SLC30A2 SLC30A5 SLC30A1 SLC30A7 SLC30A6 SLC30A8 SLC30A3 HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS%REACTOME%R-HSA-629594.3 Highly calcium permeable postsynaptic nicotinic acetylcholine receptors CHRNA6 CHRNA9 CHRNB4 CHRNB2 CHRNB3 CHRNA1 CHRNA3 CHRNA2 CHRNA5 CHRNA4 CHRNA7 MITOTIC PROPHASE%REACTOME DATABASE ID RELEASE 76%68875 Mitotic Prophase PPP2R1B PRKCB NEK9 NEK6 NUP42 NEK7 NUP43 VRK1 RAE1 CTDNEP1 RANBP2 CNEP1R1 NUP35 NUP37 MAPK1 PPP2CA PPP2CB EMD GORASP1 PPP2R1A LEMD3 H3-4 RAB1A RAB1B LEMD2 CCNB2 NUP214 CCNB1 GOLGA2 RB1 PRKCA ARPP19 NCAPH2 NCAPG2 ENSA NCAPD3 LMNB1 SET MASTL MCPH1 PPP2R2D PLK1 NUMA1 CDK1 LPIN1 LPIN2 LPIN3 H2AX H2AB1 H2AC19 RAB2A GORASP2 BLZF1 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 SEC13 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 NUP107 NUP188 H2BC11 SMC4 SMC2 BANF1 H3C15 NUP210 NUP93 H2BS1 POM121 NUP205 H2AZ1 H2BC9 H2AZ2 AAAS H4C9 H2BC8 NUP160 H2BC5 POM121C USO1 NUP85 H2BC3 TPR NUP88 H2BC1 NUP155 NUP153 H2AC20 NUP62 NDC1 NUP133 KMT5A NUP50 NUP54 EXPORT OF VIRAL RIBONUCLEOPROTEINS FROM NUCLEUS%REACTOME DATABASE ID RELEASE 76%168274 Export of Viral Ribonucleoproteins from Nucleus NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 RAN NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 XPO1 NUP155 NUP214 NUP153 PA PB2 NP NS M PB1 SEC13 NUP62 NDC1 NUP133 NUP107 HSPA1A NUP188 NUP50 NUP54 DEFECTIVE CYP27B1 CAUSES VDDR1A%REACTOME%R-HSA-5579014.3 Defective CYP27B1 causes VDDR1A CYP27B1 PTK6 ACTIVATES STAT3%REACTOME%R-HSA-8849474.1 PTK6 Activates STAT3 PTK6 STAP2 STAT3 SOCS3 RRNA PROCESSING IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-8868773.3 rRNA processing in the nucleus and cytosol RCL1 TBL3 MPHOSPH10 NOL11 NOP10 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 CSNK1D RPS4X RPS15 CSNK1E RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 SNU13 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA RPS3A RPS27A RPL9P9 RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A RPL23A RPL3L RPS26 MTREX RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 TRMT112 DDX21 RPP30 RPP38 RPP21 RPP25 RPP14 RPP40 XRN2 NOP56 RRP1 LAS1L DIS3 NOP58 RIOK2 RIOK1 TEX10 GNL3 NIP7 EXOSC10 RIOK3 EXOSC7 WDR18 EXOSC6 WDR12 EXOSC5 BYSL EXOSC4 TSR1 EXOSC9 FTSJ3 EXOSC8 EBNA1BP2 EXOSC3 NCL EXOSC2 ISG20L2 EXOSC1 NOB1 C1D LTV1 ERI1 NOL12 NOL9 PES1 BOP1 MPHOSPH6 RBM28 SENP3 PELP1 DDX49 DDX47 WDR3 FCF1 NAT10 THUMPD1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 DIMT1 WDR75 IMP4 DDX52 UTP18 DIEXF DKC1 NHP2 TSR3 HEATR1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 GAR1 RRP36 UTP20 DCAF13 UTP6 NOP2 NOP14 UTP4 PNO1 KRR1 UTP3 GLYCINE DEGRADATION%REACTOME%R-HSA-6783984.2 Glycine degradation GLDC GCSH DLD AMT CILIUM ASSEMBLY%REACTOME%R-HSA-5617833.3 Cilium Assembly HSP90AA1 CEP57 YWHAE CETN2 KIFAP3 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL SSTR3 CEP250 NEK2 PRKACA NINL CEP290 CCT3 RAB8A YWHAG CDK5RAP2 CEP97 OFD1 TCP1 DYNLL2 CEP135 KIF3B TUBB CEP131 HDAC6 HAUS4 KIF3C HAUS3 CSNK1D HAUS6 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 TTC26 MAPRE1 DYNC2I1 SFI1 CCT8 TRAF3IP1 CCT5 DYNLT2B CCT4 HSPB11 DYNC2LI1 SDCCAG8 PAFAH1B1 IFT74 DYNLT5 DYNC1I2 DYNLT2 DCTN2 IFT80 SSNA1 IFT20 DCTN3 IFT22 IFT43 PKD2 TNPO1 TTC30B IFT81 PKD1 NPHP4 CNGA2 HAUS8 TTC30A IFT27 BBS9 DYNLRB2 CNGA4 HAUS7 PRKAR2B DYNLRB1 BBS7 CEP70 BBS5 IFT46 BBS4 CLUAP1 CEP72 MKKS CYS1 CEP192 LZTFL1 C2CD3 TCTN3 BBS10 PCNT CEP76 TCTN2 RP2 TCTN1 BBS12 CLASP1 CEP78 CC2D2A CNGB1 UNC119B PLK4 IQCB1 ARL6 KIF24 DYNC1H1 ARL3 ODF2 TMEM216 FBF1 ASAP1 CEP152 TTBK2 ARL13B NDE1 INPP5E PLK1 TMEM67 NPHP1 PDE6D TUBB4B NPHP3 MARK4 TUBB4A RAB11FIP3 SEPTIN2 NEDD1 BBS2 SCLT1 CENPJ BBS1 AHI1 ALMS1 BBIP1 CDK1 CEP83 TTC8 CEP162 CEP41 B9D1 CEP43 CEP89 IFT172 B9D2 DYNC2H1 RPGRIP1L IFT88 ATAT1 SMO KIF17 KIF3A TTC21B IFT122 RAB3IP MKS1 IFT52 IFT57 IFT140 WDR35 RHO ARF4 WDR19 EXOC8 EXOC7 EXOC4 GBF1 EXOC3 RAB11A EXOC6 EXOC5 CCT2 EXOC2 EXOC1 TRIP11 MCHR1 INTRA-GOLGI AND RETROGRADE GOLGI-TO-ER TRAFFIC%REACTOME DATABASE ID RELEASE 76%6811442 Intra-Golgi and retrograde Golgi-to-ER traffic RAB6B IGF2R PLA2G4A ALPP M6PR COPE USE1 RABEPK MAN1A2 MAN1A1 NAA30 KIF28P MAN2A1 KIF5C BICD1 KIF5B BICD2 KIF5A KIF21A KIF21B KIFAP3 PLIN3 SNAP29 ACTR1A NAA35 KIF16B KIF20A NAA38 KIF20B ARFGAP3 DCTN6 ARFGAP1 DCTN5 BET1L ARFGAP2 VAMP3 DCTN1 GOSR2 KLC1 SEC22B DCTN4 GOSR1 DYNLL2 RAB1A AGPAT3 KLC4 KLC3 CYTH3 KLC2 RAB1B CYTH2 KIF3B CYTH4 RACGAP1 KIF3C BNIP1 VPS51 MAN1C1 VPS53 CYTH1 VPS52 DYNLL1 VPS54 GALNT2 YKT6 GALNT1 KIF18A KIF18B KIF4B KIF4A PAFAH1B1 DYNC1I2 DCTN2 RAB18 DCTN3 KDELR1 GCC2 GCC1 GOLGA4 GOLGA5 KIF12 GOLGA1 KIF11 ARFIP2 KIF15 KIF19 CAPZB COG8 COG7 KIF13B COG6 DYNC1H1 KIF1C COG5 KIF1B COG4 COG3 KIF1A COG2 COG1 KIF25 USP6NL KIF23 SCOC KIF22 KIF6 KIF27 ZW10 KIF9 KIF2A KDELR2 KIFC2 KDELR3 KIFC1 KIF2C KIF2B TGOLN2 DYNC1LI1 DYNC1LI2 PLA2G6 CENPE SURF4 KIF26A RAB39A KIF26B CAPZA1 CAPZA2 VPS45 KIF3A VTI1A ARF3 TMED3 TMED2 ARF4 TMED7 ARF1 TMED9 RAB33B NAPA NAPB STX16 STX18 COPZ2 NAPG STX10 COPZ1 CUX1 DYNC1I1 GBF1 VAMP4 RGP1 PAFAH1B3 CAPZA3 PAFAH1B2 ARF5 TRIP11 RAB3GAP2 RAB9A NBAS COPG2 TMF1 COPG1 ACTR10 RAB9B RAB3GAP1 ARFRP1 SYS1 STX6 STX5 RIC1 ARCN1 NSF GOLIM4 RAB43 RAB41 RINT1 RAB30 RAB36 COPB2 COPA TMED10 COPB1 ARL1 RHOBTB3 MAN2A2 RAB6A SUMO E3 LIGASES SUMOYLATE TARGET PROTEINS%REACTOME%R-HSA-3108232.5 SUMO E3 ligases SUMOylate target proteins CREBBP BLM CBX8 CBX4 NUP42 CBX2 NUP43 RAE1 RANBP2 MRTFA BMI1 CDCA8 SATB2 TFAP2B NUP35 TFAP2C NUP37 TRIM27 BRCA1 ING2 INCENP CETN2 TDG RNF2 WRN RPA1 HDAC7 SMC5 PARK7 SMC6 SMC3 DDX5 VHL HERC2 DDX17 NSMCE3 PHC2 CBX5 NSMCE2 PHC1 NSMCE1 MITF RING1 HIC1 EID3 RAD21 DNMT1 ZBED1 TP53BP1 XRCC4 STAG1 STAG2 PHC3 SP3 ZNF131 FOXL2 DNMT3B SMC1A SAFB RNF168 NSMCE4A RANGAP1 SP100 AURKA PML UHRF2 NUP214 CASP8AP2 NOP58 MBD1 RAD52 SUZ12 HNRNPK ZNF350 AURKB DAXX PARP1 HIPK2 SIN3A NCOR2 MDC1 PCGF2 PIAS4 XPC HDAC4 PIAS3 UBE2I THRB VDR NR1H2 RORA NR3C1 TP53 NR2C1 ESR1 NR3C2 CDKN2A PIAS1 NR4A2 MDM2 NR5A1 AR RXRA SUMO1 CTBP1 SUMO3 SUMO2 RARA NRIP1 PPARG PCNA PGR PPARGC1A PPARA TOP2A NPM1 CHD3 EP300 SEC13 IKBKE NUP107 NUP188 HDAC2 HDAC1 NUP210 MTA1 NUP93 POM121 NUP205 BIRC5 AAAS H4C9 NUP160 POM121C NUP85 TPR NUP88 TRIM28 NUP155 HNRNPC NUP153 NCOA1 NCOA2 NFKBIA RELA TOPORS NFKB2 IKBKG TOP2B L3MBTL2 NUP62 TOP1 SATB1 NDC1 NUP133 NUP50 NUP54 IRS ACTIVATION%REACTOME%R-HSA-74713.2 IRS activation IRS1 INSR GRB10 IRS2 INS SUNITINIB-RESISTANT PDGFR MUTANTS%REACTOME DATABASE ID RELEASE 76%9674401 Sunitinib-resistant PDGFR mutants PDGFRA APC:CDC20 MEDIATED DEGRADATION OF CELL CYCLE PROTEINS PRIOR TO SATISFATION OF THE CELL CYCLE CHECKPOINT%REACTOME%R-HSA-179419.2 APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint CCNA1 BUB1B ANAPC15 BUB3 ANAPC16 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 NEK2 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CDK1 CCNA2 DEFECTIVE CYP4F22 CAUSES ARCI5%REACTOME%R-HSA-5579005.3 Defective CYP4F22 causes ARCI5 CYP4F22 REGORAFENIB-RESISTANT KIT MUTANTS%REACTOME%R-HSA-9669929.1 Regorafenib-resistant KIT mutants KIT SYNTHESIS OF IPS IN THE ER LUMEN%REACTOME%R-HSA-1855231.2 Synthesis of IPs in the ER lumen MINPP1 CHYLOMICRON REMODELING%REACTOME%R-HSA-8963901.1 Chylomicron remodeling APOA1 LPL APOA4 APOC2 APOA5 APOE APOB GPIHBP1 APOC3 APOA2 NOTCH2 ACTIVATION AND TRANSMISSION OF SIGNAL TO THE NUCLEUS%REACTOME%R-HSA-2979096.1 NOTCH2 Activation and Transmission of Signal to the Nucleus PSEN1 UBB PSENEN JAG2 NEURL1 NCSTN UBC RPS27A PSEN2 APH1A MDK CNTN1 APH1B JAG1 UBA52 ADAM10 NOTCH2 NEURL1B DLL1 MIB2 MIB1 DLL4 FATTY ACIDS BOUND TO GPR40 (FFAR1) REGULATE INSULIN SECRETION%REACTOME%R-HSA-434316.3 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion GNA11 FFAR1 PLCB3 PLCB1 PLCB2 GNA14 GNAQ GNA15 RUNX2 REGULATES BONE DEVELOPMENT%REACTOME DATABASE ID RELEASE 76%8941326 RUNX2 regulates bone development HDAC3 CBFB HDAC6 HES1 ABL1 SMAD1 WWTR1 SMAD4 IHH SMAD6 HEY1 AR HEY2 ZNF521 MAF SATB2 MAPK1 BGLAP MAPK3 YES1 RB1 GLI3 GLI2 RBM14 UCMA COL1A1 YAP1 HDAC4 SRC SP7 DEFECTIVE SLCO2A1 CAUSES PRIMARY, AUTOSOMAL RECESSIVE HYPERTROPHIC OSTEOARTHROPATHY 2 (PHOAR2)%REACTOME%R-HSA-5619095.1 Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2) SLCO2A1 RUNX2 REGULATES CHONDROCYTE MATURATION%REACTOME%R-HSA-8941284.1 RUNX2 regulates chondrocyte maturation CBFB GLI2 IHH HDAC4 TRANSCRIPTIONAL REGULATION BY RUNX2%REACTOME DATABASE ID RELEASE 76%8878166 Transcriptional regulation by RUNX2 ITGBL1 HDAC3 CBFB RUNX1 IHH SMAD6 HEY1 HEY2 SATB2 MAPK1 MSX2 BGLAP MAPK3 STAT1 BMP2 PPARGC1B RBM14 UCMA SKP1 HDAC6 ABL1 SMAD1 WWP1 GSK3B UBA52 CUL1 AKT1 CCNB1 YES1 UBB RB1 UBC CCND1 RPS27A CDK4 ITGA5 CDK1 CDKN1A YAP1 HDAC4 SRC AKT3 HES1 NR3C1 WWTR1 SMAD4 ESR1 AR MAF RBX1 PPARGC1A SKP2 DLX5 DLX6 GLI3 GLI2 STUB1 MMP13 ESRRA SP7 PSMD8 PSMD9 PSMD6 PSMD7 NKX3-2 PSMD4 HAND2 PSMD5 PSMD2 PPM1D PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 ZNF521 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 BAX PSMD13 AKT2 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 SOX9 PSMC3 PSMC4 PSMC1 TWIST2 PSMC2 TWIST1 SMURF1 COL1A1 HIVEP3 LGALS3 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH OGG1%REACTOME%R-HSA-9656249.2 Defective Base Excision Repair Associated with OGG1 OGG1 ACYL CHAIN REMODELLING OF PE%REACTOME%R-HSA-1482839.2 Acyl chain remodelling of PE PLAAT1 PLAAT3 PLAAT2 PLAAT5 PLA2G4A PLAAT4 PLA2G6 PNPLA8 PLA2G2A LPCAT3 ABHD4 PLA2G1B PLA2G5 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G4D PLA2G2E PLA2G4E MBOAT1 PLA2G4B MBOAT2 PLA2G4C PLBD1 LPCAT4 PLA2G10 PLA2R1 PLA2G3 M PHASE%REACTOME%R-HSA-68886.3 M Phase PRKCB MAPK1 HSP90AA1 CEP57 LBR EMD YWHAE CETN2 KPNB1 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A KIF20A CNTRL LEMD3 CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 PPP2R2A OFD1 RAB1A CEP135 RAB1B TUBB VPS4A CEP131 TUBGCP2 HAUS4 HAUS3 CSNK1D HAUS6 TUBGCP5 HAUS5 CSNK1E TUBGCP6 TUBG1 TUBGCP3 DYNLL1 TUBGCP4 CKAP5 HAUS2 TUBA4A KIF18A HAUS1 AKAP9 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 UBA52 NME7 SDCCAG8 IST1 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 MZT1 DCTN3 CENPF CCNB2 CCNB1 HAUS8 GOLGA2 UBB RB1 HAUS7 PRKAR2B CEP70 UBC CEP72 CEP192 RPS27A PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 KIF23 CENPJ ALMS1 CDK1 CEP41 CEP43 ZW10 KIF2A UBE2I KIF2C KIF2B RPS27 SUMO1 CENPE H2AX H2AB1 H2AC19 RAB2A GORASP2 BLZF1 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 ANAPC15 H2AC7 ANAPC16 SEC13 ANAPC7 H2BC17 UBE2C H2BC12 UBE2E1 H2BC13 UBE2D1 ANAPC10 H2BC14 ANAPC11 H2AJ CDC23 UBE2S H2BC15 CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 H2BC11 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 NCAPG PSMD7 NCAPD2 SMC4 PSMD4 NCAPH SMC2 PSMD5 PSMD2 H3C15 DYNC1I1 BANF1 PSMD3 NUP210 PSMD1 PSMA5 NUP93 PSMA6 PSMA3 H2BS1 POM121 PSMA4 NUP205 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 PSMD10 ITGB3BP H2AZ2 AAAS H4C9 PSMB11 H2BC8 PSMD12 H2BC5 PSMD11 NUP160 POM121C PSMD14 NUP85 H2BC3 PSMD13 TPR NUP88 PSMA7 H2BC1 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 H2AC20 PSMB4 NUP153 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CHMP4C PSMC4 CHMP4B PSMC1 PSMC2 CHMP4A NUP62 NDC1 CDCA5 NUP133 PDS5B PDS5A WAPL KMT5A NUP50 NUP54 PPP2R1B PPP2R5E TUBB6 NEK9 TUBB3 NEK6 NUP42 TUBB1 NEK7 NUP43 RAE1 VRK1 RANBP2 CTDNEP1 CNEP1R1 RAN PPP2R5B CDCA8 PPP2R5A NUP35 SKA1 PPP2R5D CSNK2A1 SKA2 CHMP2B PPP2R5C NUP37 ANKLE2 CHMP2A CSNK2A2 TUBA4B CSNK2B NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC GORASP1 CENPT CENPU CHMP3 TUBA8 CENPH CHMP6 TUBA1C CENPI CHMP7 H3-4 TUBA1B TAOK1 CENPK CENPL CENPM TUBB2B TUBB2A CENPN DYNLL2 CENPO CENPP CENPQ CENPS TUBAL3 SMC3 TUBA3E TUBB8 SPAST TUBB8B LEMD2 CC2D1B TUBA3D TUBA3C CLIP1 RAD21 MAD1L1 STAG1 NDC80 STAG2 SMC1A SPDL1 XPO1 RANGAP1 TNPO1 NUP214 NSL1 PRKCA ARPP19 CDC20 NCAPH2 NCAPG2 ENSA NCAPD3 LMNB1 SET ESPL1 PTTG1 AURKB MASTL PPP1CC MCPH1 PPP2R2D KNL1 DSN1 EML4 RCC2 ZWINT NUMA1 AHCTF1 NDEL1 LPIN1 LPIN2 LPIN3 MIS12 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 SGO1 SGO2 PMF1 RCC1 BUB1B BUB3 MAD2L1 BUB1 SIRT2 FBXO5 BIRC5 USO1 MAU2 NIPBL ASSEMBLY AND CELL SURFACE PRESENTATION OF NMDA RECEPTORS%REACTOME%R-HSA-9609736.3 Assembly and cell surface presentation of NMDA receptors ACTN2 KIF17 GRIN2B GRIN1 CASK GRIN2D DLG1 LIN7A DLG2 LIN7C DLG3 LRRC7 LIN7B DLG4 NEFL GRIN2A GRIN2C CAMK2B GRIN3B CAMK2D GRIN3A NBEA CAMK2A APBA1 CAMK2G DEFECTIVE SLC5A2 CAUSES RENAL GLUCOSURIA (GLYS1)%REACTOME%R-HSA-5658208.2 Defective SLC5A2 causes renal glucosuria (GLYS1) SLC5A2 SCF-BETA-TRCP MEDIATED DEGRADATION OF EMI1%REACTOME%R-HSA-174113.3 SCF-beta-TrCP mediated degradation of Emi1 FZR1 BTRC SKP1 PSMD8 PSMD9 FBXO5 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 CDC20 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY DVL-INTERACTING PROTEINS%REACTOME DATABASE ID RELEASE 76%5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins DVL1 DVL3 CCDC88C CXXC4 DVL2 FATTY ACIDS%REACTOME DATABASE ID RELEASE 76%211935 Fatty acids CYP4F11 CYP4F12 CYP4A22 CYP2B6 CYP2A13 CYP4B1 CYP2F1 CYP4A11 CYP4F22 CYP2D6 CYP4F2 CYP2A7 CYP4F3 CYP4F8 CYP2J2 SIGNALING BY CYTOSOLIC PDGFRA AND PDGFRB FUSION PROTEINS%REACTOME%R-HSA-9673766.1 Signaling by cytosolic PDGFRA and PDGFRB fusion proteins FIP1L1 WDR48 STRN PLASMA LIPOPROTEIN CLEARANCE%REACTOME%R-HSA-8964043.1 Plasma lipoprotein clearance APOA1 NR1H2 LSR SOAT1 NPC1 SOAT2 NPC2 CES3 AP2S1 APOE LDLR APOC4 NR1H3 APOBR AP2B1 NCEH1 APOC1 APOB HDLBP PCSK9 CLTA CLTC AP2A1 VLDLR AP2A2 LIPA LIPC LDLRAP1 AP2M1 CUBN MYLIP AMN WAX BIOSYNTHESIS%REACTOME%R-HSA-9640463.1 Wax biosynthesis FAR1 FAR2 AWAT2 AWAT1 DISEASES OF IMMUNE SYSTEM%REACTOME%R-HSA-5260271.2 Diseases of Immune System IRAK4 TLR5 MYD88 LY96 FGB FGA TICAM1 CD14 TLR4 FGG S100A1 HMGB1 TIRAP mip UNC93B1 BTK porB TLR6 CD36 IKBKB CHUK NFKBIA RELA IKBKG NFKB2 TLR1 S100A9 S100A8 TLR2 TRAF3 NFKB1 TLR3 fliC TLR10 FORMATION OF HIV ELONGATION COMPLEX IN THE ABSENCE OF HIV TAT%REACTOME DATABASE ID RELEASE 76%167152 Formation of HIV elongation complex in the absence of HIV Tat CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 CCNK TCEA1 SIGNALING BY FGFR3 IN DISEASE%REACTOME DATABASE ID RELEASE 76%5655332 Signaling by FGFR3 in disease HRAS GAB1 FGF1 FGF2 PIK3CA PLCG1 FGF4 SOS1 NRAS FGFR3 FGF9 FGF20 FGF23 PIK3R1 FRS2 FGF16 FGF18 MECP2 REGULATES NEURONAL RECEPTORS AND CHANNELS%REACTOME DATABASE ID RELEASE 76%9022699 MECP2 regulates neuronal receptors and channels HDAC2 HDAC1 FKBP5 TRPC3 SIN3A OPRM1 OPRK1 CREB1 PTPN1 SLC2A3 GRIN2B PTPN4 MET GRIA2 GPRIN1 GRIN2A IKBKG DEFICIENCY CAUSES ANHIDROTIC ECTODERMAL DYSPLASIA WITH IMMUNODEFICIENCY (EDA-ID) (VIA TLR)%REACTOME%R-HSA-5603027.1 IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IKBKB CHUK IKBKG DEFECTIVE AVP DOES NOT BIND AVPR1A,B AND CAUSES NEUROHYPOPHYSEAL DIABETES INSIPIDUS (NDI)%REACTOME%R-HSA-5619099.3 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI) AVPR1A AVPR1B AVP ONCOGENIC MAPK SIGNALING%REACTOME%R-HSA-6802957.6 Oncogenic MAPK signaling ATG7 BCL2L11 BRAP FN1 TRAK1 BRAF DUSP16 KRAS AGTRAP DUSP8 DUSP9 TLN1 VCL CNKSR2 APBB1IP CNKSR1 MRAS MAPK1 LMNA SHOC2 AGK MAPK3 PAPSS1 AGGF1 PEBP1 ARRB1 ARRB2 FAM114A2 MARK3 MAP3K11 QKI PPP1CB TENT4A KIAA1549 DUSP10 AP3B1 KSR1 KSR2 IQGAP1 ESRP1 KDM7A CALM1 FAM131B FGB FGA VWF FGG AKAP9 ITGA2B MAP2K1 MAP2K2 YWHAB CLCN6 SPRED3 DUSP6 SPRED2 DUSP7 SPRED1 CAMK2B PHB CSK HRAS CAMK2D CAMK2A CAMK2G PPP1CC NRAS ITGB3 RAP1B NF1 RAP1A RAF1 ARAF JAK2 MPRIP TRIM24 SND1 SRC ZC3HAV1 FXR1 ATP SENSITIVE POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 76%1296025 ATP sensitive Potassium channels ABCC8 ABCC9 KCNJ8 KCNJ11 MUCOPOLYSACCHARIDOSES%REACTOME DATABASE ID RELEASE 76%2206281 Mucopolysaccharidoses HGSNAT NAGLU GNS SGSH IDS GUSB IDUA HYAL1 ARSB GALNS GLB1 SIGNALING BY PDGFRA EXTRACELLULAR DOMAIN MUTANTS%REACTOME%R-HSA-9673770.1 Signaling by PDGFRA extracellular domain mutants PIK3R1 STAT1 HRAS PDGFRA STAT3 PIK3CB PIK3CA SOS1 NRAS PIK3R2 RNA POLYMERASE II TRANSCRIPTION INITIATION%REACTOME%R-HSA-75953.2 RNA Polymerase II Transcription Initiation GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 BIOSYNTHESIS OF E-SERIES 18(R)-RESOLVINS%REACTOME%R-HSA-9023661.1 Biosynthesis of E-series 18(R)-resolvins ALOX5 LTA4H ALOX15 CLOSTRIDIUM NEUROTOXICITY%REACTOME%R-HSA-168799.1 Clostridium neurotoxicity SYT2 SNAP25 SYT1 botG STX1B tetX ntnha botE botD botF botA SV2C botB STX1A SV2B SV2A VAMP1 ha17 VAMP2 HA-33 ha70 CONDENSATION OF PROPHASE CHROMOSOMES%REACTOME DATABASE ID RELEASE 76%2299718 Condensation of Prophase Chromosomes SMC4 SMC2 H3C15 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AX H2AB1 CCNB1 H2AC20 H2AC19 RB1 NCAPH2 NCAPG2 H2AC14 H2BC21 NCAPD3 SET H2BU1 H3-3B H3C8 H2AC8 MCPH1 H2AC6 H2AC7 H2BC17 H2BC12 PLK1 H2BC13 H3-4 H2BC14 H2AJ H2BC15 CDK1 KMT5A H2BC11 DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR (BCR)%REACTOME%R-HSA-1168372.3 Downstream signaling events of B Cell Receptor (BCR) PRKCB PPP3R1 NFATC1 BCL10 BTRC NFKB1 CALM1 SKP1 NFKBIB PSMD8 PSMD9 PSMD6 FBXW11 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PPIA PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 NFATC2 PSME1 PSME2 RASGRP3 UBA52 PSMD10 PSMB11 PSMD12 REL PSMD11 NFKBIE PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB IKBKB PSMB3 PSMB1 HRAS PSMF1 CHUK UBC PSMB8 NFKBIA RELA PSMB9 RPS27A SEM1 IKBKG PSMC5 CARD11 PSMC6 PSMC3 RASGRP1 NRAS NFATC3 PSMC4 PSMC1 MALT1 PSMC2 PPP3CA FKBP1A PPP3CB MAP3K7 HEME BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%189451 Heme biosynthesis ALAS1 PPOX HMBS ALB ALAD CPOX FECH UROD UROS ALAS2 COX15 COX10 ABCG2 CROSS-PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS (ENDOSOMES)%REACTOME%R-HSA-1236978.1 Cross-presentation of soluble exogenous antigens (endosomes) FCGR1A FCGR1B CD207 MRC2 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 MRC1 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CD28 DEPENDENT PI3K AKT SIGNALING%REACTOME DATABASE ID RELEASE 76%389357 CD28 dependent PI3K Akt signaling MTOR MAPKAP1 PDPK1 PIK3CA CD86 LCK MAP3K14 CD80 THEM4 RICTOR CD28 PIK3R1 PIK3R3 FYN PRR5 TRIB3 AKT2 MLST8 PIK3R2 AKT1 AKT3 MAP3K8 WNT LIGAND BIOGENESIS AND TRAFFICKING%REACTOME DATABASE ID RELEASE 76%3238698 WNT ligand biogenesis and trafficking WNT5B WNT11 WNT1 WNT4 SNX3 WNT10A WLS WNT9B VPS29 WNT9A WNT8A WNT8B VPS35 TMED5 WNT7B WNT7A WNT6 VPS26A WNT2 WNT3 WNT2B PORCN WNT10B WNT3A WNT5A WNT16 PINK1-PRKN MEDIATED MITOPHAGY%REACTOME DATABASE ID RELEASE 76%5205685 PINK1-PRKN Mediated Mitophagy TOMM22 UBB PRKN TOMM40 VDAC1 UBC SQSTM1 MFN1 RPS27A MAP1LC3B MFN2 MTERF3 ATG5 ATG12 UBA52 MAP1LC3A TOMM20 TOMM7 TOMM5 PINK1 TOMM6 TOMM70 DNA DAMAGE TELOMERE STRESS INDUCED SENESCENCE%REACTOME%R-HSA-2559586.3 DNA Damage Telomere Stress Induced Senescence CCNA1 CCNE2 CCNE1 TP53 CDK2 ATM HIRA EP400 HMGA1 HMGA2 H2AX CABIN1 H2AB1 H2AC19 H2AC14 H2BC21 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 RAD50 H2BC11 H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 RB1 ASF1A H1-1 H1-0 H1-3 LMNB1 H1-2 H1-5 H1-4 UBN1 MRE11 KAT5 NBN CDKN1A CDKN1B CCNA2 REGULATION OF HMOX1 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 76%9707587 Regulation of HMOX1 expression and activity KEAP1 RBX1 CSNK2A1 CSNK2A2 CSNK2B SKP2 NFE2L2 HM13 FBXL17 BACH1 SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 MAFK PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PRKCD PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 HMOX1 DEFECTIVE F9 ACTIVATION%REACTOME%R-HSA-9673221.1 Defective F9 activation GP5 GP9 F9 GP1BB F11 GP1BA METABOLISM OF COFACTORS%REACTOME%R-HSA-8978934.4 Metabolism of cofactors GCH1 COQ5 PTS COQ3 HSP90AA1 PRKG2 COQ2 NOS3 PDSS2 PDSS1 DHFR SPR CALM1 IDH1 COQ9 AKT1 COQ7 COQ6 GCHFR CONSTITUTIVE SIGNALING BY ABERRANT PI3K IN CANCER%REACTOME%R-HSA-2219530.1 Constitutive Signaling by Aberrant PI3K in Cancer ESR1 GAB1 TGFA STRN PIK3CA FLT3 LCK CD28 KIT FYN RHOG VAV1 PDGFB PDGFRB HGF ERBB2 ESR2 PTPN11 CD86 CD80 PIK3R1 AREG PIK3R2 TRAT1 NRG1 NRG2 PIK3AP1 NRG3 NRG4 EGF EPGN HBEGF EGFR KLB IRS1 PDGFRA IRS2 PIK3CB FGF1 FGF2 FGF3 FGF4 FGF6 FGF7 FGF9 PIK3CD FGF20 RAC2 RAC1 FGF23 FGF22 FLT3LG PIK3R3 FRS2 GAB2 MET FGF16 FGF19 EREG FGF18 BTC FGFR4 SRC FGF10 CD19 PKA ACTIVATION IN GLUCAGON SIGNALLING%REACTOME%R-HSA-164378.3 PKA activation in glucagon signalling PRKAR2B ADCY4 PRKACG ADCY3 PRKACB ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY9 ADCY5 PRKAR1B PRKAR1A PRKACA PRKAR2A GNAS TGFBR1 KD MUTANTS IN CANCER%REACTOME%R-HSA-3656532.2 TGFBR1 KD Mutants in Cancer TGFB1 SMAD3 TGFBR1 TGFBR2 SMAD2 LAMININ INTERACTIONS%REACTOME DATABASE ID RELEASE 76%3000157 Laminin interactions LAMB3 NID1 LAMB1 ITGB4 COL18A1 NID2 ITGB1 LAMC2 LAMC1 ITGAV ITGA6 ITGA2 ITGA1 LAMC3 HSPG2 LAMA5 LAMA2 LAMA1 LAMB2 LAMA3 ITGA3 ITGA7 LAMA4 INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 76%176033 Interactions of Vpr with host cellular proteins BANF1 NUP42 NUP210 NUP43 rev RAE1 gag-pol vif RANBP2 NUP93 vpr POM121 PSIP1 vpu NUP205 NUP35 SLC25A5 NUP37 SLC25A4 AAAS NUP160 SLC25A6 POM121C NUP85 TPR HMGA1 NUP88 NUP155 KPNA1 NUP214 NUP153 SEC13 gag NUP62 NDC1 NUP133 NUP107 NUP188 NUP50 NUP54 TRANSFERRIN ENDOCYTOSIS AND RECYCLING%REACTOME DATABASE ID RELEASE 76%917977 Transferrin endocytosis and recycling ATP6V1B2 ATP6V1B1 TCIRG1 ATP6V1G3 ATP6V0D1 ATP6V0E2 ATP6V0D2 HFE ATP6V0A2 ATP6V0A4 TFR2 TFRC ATP6V1C1 ATP6V0A1 ATP6V1H ATP6V1C2 TF STEAP2 STEAP3 ATP6V1A ATP6V1D ATP6V1F MCOLN1 ATP6V0B ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6AP1 ATP6V0C ESSENTIAL PENTOSURIA%REACTOME%R-HSA-5662853.2 Essential pentosuria DCXR ABACAVIR METABOLISM%REACTOME%R-HSA-2161541.3 Abacavir metabolism GUK1 PCK1 ADH1A ADAL NT5C2 NADPH REGENERATION%REACTOME DATABASE ID RELEASE 76%389542 NADPH regeneration IDH1 ACTIVATION OF SMO%REACTOME DATABASE ID RELEASE 76%5635838 Activation of SMO EVC2 ARRB1 ARRB2 SHH DHH IHH CSNK1A1 SMO CDON KIF3A EFCAB7 GRK2 BOC PTCH1 IQCE EVC GAS1 GAS8 TP53 REGULATES TRANSCRIPTION OF GENES INVOLVED IN CYTOCHROME C RELEASE%REACTOME%R-HSA-6803204.1 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release CREBBP BNIP3L TP53 TRIAP1 BBC3 TP53BP2 AIFM2 ATM PMAIP1 TP53INP1 ZNF420 TP73 TP53AIP1 BID BAX PPP1R13B TP63 STEAP3 PRELID3A PRELID1 TRANSPORT OF FATTY ACIDS%REACTOME%R-HSA-804914.1 Transport of fatty acids APOD LCN9 SLC27A1 SLC27A4 LCN15 LCN1 LCN12 SLC27A6 INTERACTION BETWEEN PHLDA1 AND AURKA%REACTOME%R-HSA-8854521.2 Interaction between PHLDA1 and AURKA AURKA PHLDA1 DEFECTIVE EXT2 CAUSES EXOSTOSES 2%REACTOME%R-HSA-3656237.2 Defective EXT2 causes exostoses 2 GPC5 GPC4 GPC6 EXT1 EXT2 SDC1 AGRN HSPG2 SDC4 SDC2 SDC3 GPC1 GPC3 GPC2 ACTIVATION OF BAD AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111447.2 Activation of BAD and translocation to mitochondria YWHAZ PPP3R1 BCL2 YWHAE PPP3CC BID YWHAB YWHAQ AKT2 YWHAG SFN YWHAH AKT1 BAD AKT3 SYNTHESIS AND PROCESSING OF GAG, GAGPOL POLYPROTEINS%REACTOME%R-HSA-174495.1 Synthesis And Processing Of GAG, GAGPOL Polyproteins UBB MVB12B UBC UBAP1 MVB12A RPS27A NMT2 VPS28 VPS37C gag VPS37D VPS37A VPS37B UBA52 TSG101 PLC BETA MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 76%112043 PLC beta mediated events PLCB3 PLCB1 PLCB2 KPNA2 PRKACG PRKACB PLA2G4A PLCB4 ADCY9 PRKAR1B CAMKK1 CAMKK2 PRKAR1A MAPK1 PDE1B PDE1A PRKAR2A ITPR1 ITPR2 ITPR3 PRKX NBEA GNAQ PDE1C ADCY4 ADCY3 ADCY2 ADCY1 ADCY8 ADCY7 ADCY6 ADCY5 PRKACA CALM1 PRKCG GNA14 GNA15 GNA11 AHCYL1 PRKCD PRKCA CAMK2B PRKAR2B CAMK2D CAMK2A CAMK2G CREB1 CAMK4 GRK2 NON-INTEGRIN MEMBRANE-ECM INTERACTIONS%REACTOME%R-HSA-3000171.3 Non-integrin membrane-ECM interactions LAMB3 LAMB1 DAG1 ACTN1 TRAPPC4 SDC1 ITGB1 LAMC2 AGRN LAMC1 DMD LAMC3 LAMA2 LAMA1 NRXN1 THBS1 CASK LAMA4 PDGFB PRKCA TTR ITGB4 FGF2 ITGB3 VTN ITGAV ITGA6 TGFB1 ITGA2 HSPG2 LAMA5 SDC4 SDC2 LAMB2 SDC3 LAMA3 NTN4 PDGFA DDR1 ITGB5 TNC DDR2 FOXO-MEDIATED TRANSCRIPTION OF CELL CYCLE GENES%REACTOME%R-HSA-9617828.1 FOXO-mediated transcription of cell cycle genes GADD45A FOXO3 SMAD4 FOXG1 PCBP4 SMAD3 RBL2 BTG1 MSTN CAV1 FOXO1 KLF4 CDKN1A CDKN1B CCNG2 SMAD2 FOXO4 INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING%REACTOME DATABASE ID RELEASE 76%6785807 Interleukin-4 and Interleukin-13 signaling SOCS5 IRF4 TNFRSF1B FN1 POU2F1 IL10 FCER2 ITGB1 CXCL8 ALOX15 IL18 ZEB1 IL1A IL1B IL13RA2 IL13RA1 FSCN1 NDN MCL1 PIM1 NOS2 HGF LIF LBP HSP90AA1 STAT1 IL2RG LCN2 HSPA8 IL13 OSM BATF OPRM1 IL4R IL4 PIK3R1 JUNB IGHG4 IGHG1 GATA3 S1PR1 CCL2 IL23A IL23R IL12B TYK2 STAT3 POMC MAOA AKT1 IL6 ITGAM IL12A ITGB2 CCND1 VEGFA ITGAX MYC JAK2 RORC CDKN1A ANXA1 FOXO3 RORA RHOU TP53 IGHE FOS OPRD1 CCL11 MUC1 CD36 TNF TIMP1 ALOX5 PTGS2 MMP1 MMP2 MMP3 MMP9 IL17F IL17A CCL22 JAK3 LAMA5 IL6R NANOG SOCS1 BCL6 JAK1 F13A1 SAA1 BCL2 BCL2L1 FASLG HIF1A SOCS3 ICAM1 HSP90B1 BIRC5 STAT6 FOXO1 VIM SOX2 FGF2 TWIST1 CEBPD TGFB1 VCAM1 COL1A2 HMOX1 MPS IIIA - SANFILIPPO SYNDROME A%REACTOME DATABASE ID RELEASE 76%2206307 MPS IIIA - Sanfilippo syndrome A SGSH APOBEC3G MEDIATED RESISTANCE TO HIV-1 INFECTION%REACTOME%R-HSA-180689.1 APOBEC3G mediated resistance to HIV-1 infection gag BANF1 rev gag-pol vif HMGA1 PPIA vpr PSIP1 vpu SIGNALING BY HIPPO%REACTOME DATABASE ID RELEASE 76%2028269 Signaling by Hippo NPHP4 MOB1B WWTR1 MOB1A STK4 STK3 LATS1 LATS2 YWHAE TJP1 TJP2 YWHAB WWC1 AMOTL2 CASP3 AMOTL1 YAP1 DVL2 SAV1 NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION%REACTOME DATABASE ID RELEASE 76%164940 Nef mediated downregulation of MHC class I complex cell surface expression PACS1 AP1S2 AP1M2 AP1S1 AP1M1 AP1B1 AP1S3 AP1G1 nef B2M HLA-A DEFECTIVE SLC5A1 CAUSES CONGENITAL GLUCOSE GALACTOSE MALABSORPTION (GGM)%REACTOME DATABASE ID RELEASE 76%5656364 Defective SLC5A1 causes congenital glucose galactose malabsorption (GGM) SLC5A1 P2Y RECEPTORS%REACTOME DATABASE ID RELEASE 76%417957 P2Y receptors GPR17 P2RY4 P2RY12 P2RY13 P2RY10 P2RY2 P2RY11 P2RY1 LPAR6 P2RY14 P2RY6 LPAR4 DEFECTIVE SLC35A3 CAUSES ARTHROGRYPOSIS, MENTAL RETARDATION, AND SEIZURES (AMRS)%REACTOME%R-HSA-5619083.1 Defective SLC35A3 causes arthrogryposis, mental retardation, and seizures (AMRS) SLC35A3 DEFECTIVE DPAGT1 CAUSES DPAGT1-CDG (CDG-1J) AND CMSTA2%REACTOME%R-HSA-4549356.1 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 DPAGT1 MMR%REACTOME DATABASE ID RELEASE 76%5358508 MMR POLD2 MSH3 MSH6 MSH2 LIG1 PCNA RPA1 RPA2 PMS2 MLH1 RPA3 POLD3 POLD4 EXO1 POLD1 LXRS REGULATE GENE EXPRESSION TO CONTROL BILE ACID HOMEOSTASIS%REACTOME DATABASE ID RELEASE 76%9623433 LXRs regulate gene expression to control bile acid homeostasis NCOR1 NR1H2 NCOA1 FABP6 UGT1A3 RXRA NCOR2 RXRB NR1H3 NEGATIVE EPIGENETIC REGULATION OF RRNA EXPRESSION%REACTOME%R-HSA-5250941.2 Negative epigenetic regulation of rRNA expression SIRT1 CCNH POLR2E POLR2F POLR2H H2AX H2AB1 POLR2K H2AC19 POLR2L GTF2H1 TTF1 GTF2H2 H2AC14 H2BC21 GTF2H3 GTF2H4 H2BU1 H3-3B GTF2H5 H3C8 CDK7 H2AC8 ERCC3 TBP ERCC2 H2AC6 MNAT1 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 POLR1A POLR1B POLR1C H2BC11 POLR1D POLR1E POLR1F POLR1G POLR1H HDAC2 HDAC1 TAF1D H3C15 TAF1B TAF1C ARID4B TAF1A RRP8 H2BS1 SAP130 SAP30BP SAP30 DNMT1 BAZ2A H2AZ1 SUDS3 H2BC9 H2AZ2 SUV39H1 H4C9 H2BC8 H2BC5 SIN3B DNMT3B H2BC3 SMARCA5 H2BC1 H2AC20 SAP30L SAP18 MBD2 SIN3A UBTF ZINC INFLUX INTO CELLS BY THE SLC39 GENE FAMILY%REACTOME DATABASE ID RELEASE 76%442380 Zinc influx into cells by the SLC39 gene family SLC39A10 SLC39A1 SLC39A14 SLC39A3 SLC39A6 SLC39A5 SLC39A8 SLC39A7 SLC39A2 SLC39A4 RUNX3 REGULATES IMMUNE RESPONSE AND CELL MIGRATION%REACTOME%R-HSA-8949275.1 RUNX3 Regulates Immune Response and Cell Migration ITGAL CBFB ITGA4 RUNX3 SPP1 RESISTANCE OF ERBB2 KD MUTANTS TO SAPITINIB%REACTOME DATABASE ID RELEASE 76%9665244 Resistance of ERBB2 KD mutants to sapitinib HSP90AA1 CDC37 ERBB2 ERBIN EXTRA-NUCLEAR ESTROGEN SIGNALING%REACTOME DATABASE ID RELEASE 76%9009391 Extra-nuclear estrogen signaling FOXO3 ESR1 TGFA STRN PIK3CA PRMT1 FOS ELK1 MAPK1 GNG10 MAPK3 GNAI3 GNG12 GNAI1 GNG11 HSP90AA1 GNAI2 GNG13 MMP7 UHMK1 GNB2 MMP2 GNB1 MMP3 NOS3 PDPK1 ESR2 GNB4 MMP9 GNB3 GNB5 GNGT1 PIK3R1 GNGT2 AREG SPHK1 CALM1 IGF1R PIK3R2 BCL2 GNG3 GNG2 S1PR3 EGF GNG5 ZDHHC7 GNG4 EPGN GNG7 GNG8 CAV1 HBEGF EGFR CAV2 AKT2 XPO1 AKT1 SRF PTK2 GNAT3 HRAS CCND1 NRAS CREB1 PIK3R3 PRKCZ EREG BTC CDKN1B SRC ZDHHC21 AKT3 DEFECTIVE AMN CAUSES HEREDITARY MEGALOBLASTIC ANEMIA 1%REACTOME%R-HSA-3359462.1 Defective AMN causes hereditary megaloblastic anemia 1 CBLIF CUBN AMN DEFECTIVE ABCB11 CAUSES PFIC2 AND BRIC2%REACTOME%R-HSA-5678520.2 Defective ABCB11 causes PFIC2 and BRIC2 ABCB11 ACTIVATION OF NA-PERMEABLE KAINATE RECEPTORS%REACTOME%R-HSA-451307.3 Activation of Na-permeable kainate receptors GRIK1 GRIK2 NGF-INDEPENDANT TRKA ACTIVATION%REACTOME DATABASE ID RELEASE 76%187024 NGF-independant TRKA activation ADCYAP1 ADCYAP1R1 ADORA2A NTRK1 NTRK2 EPH-EPHRIN MEDIATED REPULSION OF CELLS%REACTOME%R-HSA-3928665.3 EPH-ephrin mediated repulsion of cells PSEN1 PSENEN NCSTN EPHA5 EPHA4 EFNA1 EPHA7 EFNA3 EPHA6 EFNA2 EPHA8 EPHA2 EPHB6 EPHA1 EFNB2 EFNB1 EPHA3 EFNB3 EPHA10 FYN AP2S1 VAV3 EPHB2 EPHB1 EPHB4 EPHB3 LYN YES1 DNM1 AP2B1 MMP2 MMP9 PSEN2 APH1A CLTA APH1B CLTC AP2A1 CLTB RAC1 VAV2 AP2A2 ADAM10 TIAM1 CLTCL1 AP2M1 EFNA5 EFNA4 REGULATION OF IGF ACTIVITY BY IGFBP%REACTOME DATABASE ID RELEASE 76%381426 Regulation of IGF Activity by IGFBP FN1 APP PRKCSH GAS6 BPIFB2 APOB MGAT4A C3 MEN1 PENK IL6 CKAP4 PAPPA2 C4A IGFALS KTN1 IGFBP2 IGFBP6 PAPPA KLK1 KLK3 ADAM10 SDC2 GPC3 KLK2 F2 TGOLN2 KLK13 LAMC1 TF CTSG GZMH TIMP1 IGFBP3 MMP1 MIA3 MMP2 SERPINA1 PCSK9 IGFBP1 IGF1 IGF2 PLG SERPINC1 CSF1 VCAN TNC APOA2 SPP1 DMP1 APOA1 LGALS1 CDH2 EVA1A APOA5 LAMB1 CCN1 CHGB IGFBP5 IGFBP4 FGA APLP2 SERPIND1 SHISA5 PDIA6 MXRA8 SPARCL1 SCG3 SCG2 FGG LTBP1 HSP90B1 STC2 IGFBP7 F5 AMELX WFS1 AMBN FUCA2 PROC APOE TMEM132A BMP4 HRC CALU MELTF FBN1 MBTPS1 SERPINA10 MSLN CHRDL1 PRSS23 CP BMP15 QSOX1 AHSG MEPE ALB DNAJC3 RCN1 P4HB VGF ENAM AMTN VWA1 KNG1 FAM20C FAM20A MFGE8 MATN3 ITIH2 AFP FGF23 FSTL1 ANO8 FSTL3 CST3 SPP2 APOL1 GOLM1 LAMB2 NUCB1 NOTUM PNPLA2 DNA DAMAGE RECOGNITION IN GG-NER%REACTOME DATABASE ID RELEASE 76%5696394 DNA Damage Recognition in GG-NER MCRS1 INO80 DDB2 RBX1 GPS1 YY1 UBA52 COPS4 COPS2 UBB ACTB UBC RUVBL1 NFRKB RPS27A CETN2 PARP1 PARP2 DDB1 ACTR5 ACTL6A COPS7B COPS7A RAD23A ACTR8 CUL4A COPS3 RAD23B COPS6 INO80C COPS5 INO80B INO80E INO80D XPC COPS8 CUL4B TFPT LGK974 INHIBITS PORCN%REACTOME DATABASE ID RELEASE 76%5340573 LGK974 inhibits PORCN PORCN GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE%REACTOME%R-HSA-210500.4 Glutamate Neurotransmitter Release Cycle SLC1A2 GLS SLC1A6 SNAP25 SYT1 SLC1A7 UNC13B RAB3A CPLX1 RIMS1 PPFIA1 STX1A TSPOAP1 PPFIA4 PPFIA3 VAMP2 PPFIA2 SLC1A1 SLC1A3 ARL6IP5 SLC38A2 SLC17A7 GLS2 DEFECTIVE GAMMA-CARBOXYLATION OF F9%REACTOME%R-HSA-9673240.1 Defective gamma-carboxylation of F9 F9 GGCX GAP JUNCTION ASSEMBLY%REACTOME DATABASE ID RELEASE 76%190861 Gap junction assembly GJA4 GJB2 GJD2 GJB1 GJA9 GJB4 GJD4 GJB3 GJA8 GJD3 GJB6 GJB5 GJB7 GJA10 GJC1 GJC2 GJA1 GJA3 GJA5 PHENYLALANINE AND TYROSINE METABOLISM%REACTOME%R-HSA-8963691.1 Phenylalanine and tyrosine metabolism KYAT1 ASRGL1 QDPR GSTZ1 IL4I1 HGD FAH TAT PCBD1 PAH RIPK1-MEDIATED REGULATED NECROSIS%REACTOME DATABASE ID RELEASE 76%5213460 RIPK1-mediated regulated necrosis 3a OGT FASLG FAS CASP8 TRADD RIPK1 TRAF2 FADD BIRC2 SDCBP UBA52 BIRC3 XIAP FLOT1 UL36 TNFSF10 FLOT2 PDCD6IP TNFRSF10B RIR1 TNFRSF10A PELI1 UBB MLKL HSP90AA1 CDC37 UBC NS RPS27A STUB1 CRMA RIPK3 SPI-2 AXONAL GROWTH STIMULATION%REACTOME%R-HSA-209563.2 Axonal growth stimulation NGF ARHGDIA RHOA NGFR REMOVAL OF AMINOTERMINAL PROPEPTIDES FROM GAMMA-CARBOXYLATED PROTEINS%REACTOME DATABASE ID RELEASE 76%159782 Removal of aminoterminal propeptides from gamma-carboxylated proteins F7 PROC F2 F9 F10 FURIN BGLAP PROS1 PROZ GAS6 FCGR ACTIVATION%REACTOME%R-HSA-2029481.1 FCGR activation V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV V5-4 V5-1 SYK FGR FYN V5-6 HCK IGLV3-19 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 IGLV IGHG3 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN YES1 IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 FCGR2A CD3G IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 SIGNALING BY FGFR1%REACTOME DATABASE ID RELEASE 76%5654736 Signaling by FGFR1 FLRT3 BRAF GAB1 PIK3CA PLCG1 FRS3 SOS1 MKNK1 SPRY2 UBA52 MAPK1 FGFRL1 MAPK3 PPP2CA SPRED2 PPP2CB UBB SPRED1 HRAS UBC FGF1 RPS27A FGF2 FGF3 FGF4 FGF6 NRAS PTPN11 ANOS1 FGF9 FGF20 PPP2R1A FGF23 PIK3R1 FGF22 FLRT2 FLRT1 FRS2 FGF18 CBL FGF10 INTERLEUKIN-1 FAMILY SIGNALING%REACTOME DATABASE ID RELEASE 76%446652 Interleukin-1 family signaling GSDMD TAB1 UBE2V1 MAP2K6 APP IL18 IL1A IL1B IL36A IL36B IL36G IL13 IL18RAP PTPN11 IL36RN IL4 TOLLIP BTRC NFKB1 PTPN6 NKIRAS1 SKP1 NKIRAS2 MAPK8 NFKBIB PTPN18 FBXW11 IL37 PTPN20 PTPN23 PTPN14 IL18BP PTPN9 PTPN5 PTPN2 IL18R1 UBA52 MAP2K1 STAT3 CUL1 UBB UBC PTPN13 RPS27A SMAD3 RBX1 IL1RL2 IL1RAPL1 IL1F10 HMGB1 CTSG PELI1 ALOX5 SQSTM1 TBK1 IL1RN IL1R2 MAP3K3 IL1R1 PSMD8 PSMD9 PSMD6 IRAK4 PSMD7 SAA1 PSMD4 MYD88 PSMD5 PSMD2 PSMD3 PSMD1 CASP1 PSMA5 IL1RL1 PSMA6 IL33 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PTPN4 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 MAP3K8 PSMB4 PSMB5 MAP2K4 PSMB2 SIGIRR IKBKB PSMB3 PSMB1 PSMF1 CHUK TNIP2 NFKBIA IRAK3 PSMB8 PELI3 RELA PSMB9 SEM1 PELI2 NFKB2 IKBKG PTPN12 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NOD1 NOD2 AGER IRAK1 IRAK2 PTPN7 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 BUDDING AND MATURATION OF HIV VIRION%REACTOME%R-HSA-162588.2 Budding and maturation of HIV virion VPS4A MVB12B MVB12A rev VTA1 gag-pol vif PPIA nef vpr vpu VPS28 CHMP2B CHMP2A UBA52 NEDD4L env PDCD6IP UBB UBC UBAP1 RPS27A CHMP4C CHMP4B CHMP3 CHMP4A gag VPS37C VPS37D VPS37A CHMP6 VPS37B CHMP7 CHMP5 TSG101 VPS4B NEUROFASCIN INTERACTIONS%REACTOME%R-HSA-447043.1 Neurofascin interactions NFASC NRCAM SDCBP DCX ANK1 CNTNAP1 CNTN1 AKT PHOSPHORYLATES TARGETS IN THE NUCLEUS%REACTOME DATABASE ID RELEASE 76%198693 AKT phosphorylates targets in the nucleus FOXO3 FOXO1 AKT2 FOXO6 NR4A1 AKT1 RPS6KB2 CREB1 AKT3 FOXO4 LDL REMODELING%REACTOME%R-HSA-8964041.1 LDL remodeling APOF APOB LPA CETP AURKA ACTIVATION BY TPX2%REACTOME%R-HSA-8854518.3 AURKA Activation by TPX2 HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 HAUS3 HMMR CSNK1D HAUS6 TPX2 HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 SFI1 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 AURKA HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 TFAP2 (AP-2) FAMILY REGULATES TRANSCRIPTION OF OTHER TRANSCRIPTION FACTORS%REACTOME%R-HSA-8866906.2 TFAP2 (AP-2) family regulates transcription of other transcription factors TFAP2C CITED2 TFAP2A PITX2 IMMUNE SYSTEM%REACTOME DATABASE ID RELEASE 76%168256 Immune System CREBBP CSF2 PRKCB RHOF DIAPH1 RNF213 ATP6V1H MAPK1 ITGB7 MAPK3 KPNA1 NOS2 CD180 LY86 LBP KPNB1 GSN RAB7A MSN RPLP0 MAP2K1 PLD4 PLD3 PTPRC PIK3CD TREM2 ITGAV EVL NFASC VASP SIAH1 CAP1 ACTB LCP2 EP300 H3C8 ENAH TYROBP POLR1C POLR1D H3C15 NCAM1 MAPK12 IFIH1 MAPK13 IKBKB RNF135 MAVS CHUK DDX58 CASP10 TRIM25 CASP9 IKBKG ADAR BTNL9 BTNL8 BTN3A1 BTN2A2 BTN2A1 CD209 BTN1A1 BTN3A3 BTNL2 BTN3A2 PPL XDH CSF3 FBXO4 FBXO6 FBXW4 FBXW5 FBXW10 FBXW7 FBXW9 JUP FBXW2 ARHGAP9 CSNK2B LRRC41 FLNA FBXL3 FBXL5 BRWD1 TCP1 STK10 PTK2B CCT8 NF2 STAT3 MAOA CSK VEGFA BLK DSN1 B4GALT1 HEXB FAF2 RHOU SDC1 ARHGAP45 SKP2 FZR1 ZAP70 VNN1 MOSPD2 fliC TLR10 IRAK4 TLR5 MYD88 TICAM2 LY96 FASLG TICAM1 CD14 TLR4 DAPP1 RASGRP3 CD79B CAB39 CD79A REL NFKBIE CD22 IGHM AKT2 BLNK IGHD MLST8 EIF4E GYG1 MTOR LAMTOR2 LAMTOR1 DBNL LAMTOR3 PKP1 PTPN7 COL1A2 ITGB5 ANXA2 FCER2 ITGB1 VCL CYFIP1 NCKAP1 NCF1 NCF2 SNAP23 NCF4 BRK1 CRKL STAT1 STBD1 CYBB CYBA CD86 CD80 CSF3R VAV2 RAPGEF1 VAMP3 PIK3R2 RACGAP1 ABL2 NCKAP1L WASF1 WASF2 RELB STXBP2 UBA3 IL32 MAP3K14 UBE2M BAIAP2 ABI2 ABI1 HNRNPF CCND1 TIFA ALPK1 ITGAL MYC IL21 IL21R LGALS9 HAVCR2 IL15RA ITGA4 IL15 HNRNPA2B1 FOXO3 BCL2L11 SMAD3 SMURF2 CTNNB1 KRAS OTUD5 NLRX1 UBA7 UBE2D2 UBE2D3 NLRC5 TNFAIP3 UBE2L6 HERC5 TBK1 RNF216 PCBP2 IKBKE ATG5 ISG15 ATG12 CYLD RNF125 IRF3 TRAF3 TAX1BP1 PIN1 UBE2K SNRPA1 PROS1 F13A1 PRCP CD177 FGB FGA FGG GUSB SERPING1 HPSE INPP5D ATF1 MAP3K8 MAP2K3 MAP2K4 SIGIRR MAPKAPK3 MAP2K7 ECSIT IRAK3 PELI3 PELI2 MAPK9 MAP3K1 MAPK10 EEF1A1 EEF2 PPP2R1B PPP2R5E MGST1 NOS1 CYB5R3 PPP2R5B PPP2R5A PPP2R5D PPP2R5C FGR STIM1 PECAM1 ORAI2 ORAI1 ITPR1 ITPR2 ITPR3 PPP2CA PPP2CB GSTO1 PLPP5 APOB PLPP4 NOS3 GSTP1 PTPN11 P2RX7 LAT AOC1 P2RX1 PTPN6 CALM1 MAPK8 DYNLL2 PTPN18 GSTA2 KLRK1 fljB EEA1 KIR3DS1 prgJ FCER1A NCR2 MS4A2 KIR2DS2 KIR2DS4 KIR2DS5 ITK AIP CD300LB TREM1 TXK SIGLEC16 SIGLEC15 CD300E MTAP NLRP1 KLRC2 KLRD1 AIM2 TNFRSF12A TNFSF12 TNFRSF11A TNFRSF13C CD40LG LTBR LTB PVR NECTIN2 ARG1 IL25 IL17RE IL17RC IL17RB IL17RA IL17F IL17C IL17A COLEC12 KCNAB2 CXADR CD74 JAML CD99 IL22 IL20 IL26 IL24 IL20RA IL20RB IL22RA2 IFNL2 IFNL1 IFNL3 IL10RB IL19 IFNLR1 IL22RA1 FYB1 TREML1 TREML4 TREML2 HCST HLA-DMA HLA-DMB KIR3DL1 BIN2 KIR3DL2 SIGLEC1 SIGLEC8 CD19 ATG7 SIGLEC7 SIGLEC6 HN FN1 HLA-DOA HLA-DOB LAG3 PIANP RILP GRB2 FCGR2B CD226 CD1D CD1C CD1B CD1A SLAMF7 SLAMF6 PAG1 PILRB PILRA CD200 CTSO CTSF CTSE NCR1 NCR3 MICA MICB NPDC1 MIB2 CD96 CD8A KIR2DL1 KIR2DL2 KIR2DL3 PIM1 KIR2DL4 CRTAM HGF KIR2DS1 KIF5C CD200R1 KIF5B CLEC4G CD300LD KIF5A CD300LF CD300LG CD160 PTPN22 KIFAP3 IFNA13 CLEC2B IFNA14 CLEC2D IFNA16 CD101 IFNA17 cd21 SIGLEC12 SIGLEC11 KIF20A SIGLEC10 SH2D1A SH2D1B IFNA10 RAET1E LILRA6 LILRA1 LILRA2 LILRA4 GATA3 LILRA5 KLC1 NCR3LG1 LAIR2 GLYCAM1 LILRB1 KLC4 LILRB4 KLC3 LILRB5 KLC2 KLRF1 TRAT1 KIF3B CD300C KLRB1 PIK3AP1 ABL1 KLRC1 KIF3C ULBP1 IFNA21 ULBP3 KLRG1 RAG2 RAG1 KIF18A MLEC KIF4B KIF4A PDIA3 IFNA5 CALR IFNA4 HLA-H IFNA7 HLA-B HLA-C IFNA6 HLA-F HLA-G HLA-E IFNA2 FCN1 HBB FCN2 FCN3 CD81 C4BPA KIF11 IFNA8 C4BPB C4A KIF15 MASP1 CPB2 CFH CAPZB CFI C4B_2 C2 VTN C6 RAC1 C7 C9 JAK2 C8B SLA C8A SLA2 C8G MBL2 KIF23 CR2 KIF22 CR1 RBSN CD46 C1QB CRP C1QA COLEC11 COLEC10 KIF2A C1S C1R CPN2 IRF1 CPN1 IRF2 CFHR2 KIF2C CFHR1 KIF2B CFHR4 DOCK2 CFHR3 DOCK1 CFHR5 C1QC LAT2 IGHE SH2B3 IFNB1 CENPE KIF26A CAPZA1 CAPZA2 TANK ALOX5 PTGS2 NS HA CLTA AP2A1 TRIM63 AP2A2 CAT RETN FBXO32 AP2M1 MYLIP CSF1 NPC2 SAR1B HSP90B1 FUCA2 AP2S1 AP2B1 QSOX1 AHSG DNAJC3 P4HB PPIE CST3 ALOX15 PRKCSH MAGT1 DDOST CANX CTLA4 SLCO4C1 MUC13 DSP PTPN13 CKAP4 DSG1 RORC AKT3 AP1S2 AP1S1 AP1S3 DYNC1LI1 DYNC1LI2 PLA2G6 GNS LNPEP ARF1 SERPINA1 ARPC1A VAMP8 VAMP7 VAMP2 PAFAH1B2 IL2RA PTPN4 STX4 RAB3A RAB31 FTL RAB5B RAB5C SMARCA4 RAB6A AP1M2 AP1M1 TXNDC5 TRAPPC1 ARPC4 ARPC5 ARPC2 ARPC3 IL2 IL3 AP1G1 SNAP29 ACTR2 JUNB SEC22B SEC23A IL37 PTPN20 PTPN23 PTPN14 IL18BP PTPN9 PTPN5 PTPN2 IL18R1 SEC24B SEC24A NFATC2 RAB10 MYO1C RAB14 RAB18 SEC24D SEC24C FTH1 TBC1D10C AP1B1 TSLP IL7 CRLF2 SEC31A SPTBN2 SURF4 MYO5A RAB27A SH3KBP1 CTSZ CSF1R GDI2 CD3G CD3D CTSC SEC13 IL1RN IL1R2 MAP3K3 CD59 DYNC1I1 CD55 CAPZA3 ACTR10 RAB9B SH3GL2 SOX2 TWIST1 COPB1 LIFR KCTD6 POU2F1 IGF2R CNTFR CNTF IL31RA ZEB1 CTF1 STX3 IL10RA CLCF1 IL13RA2 IL13RA1 TXLNA FSCN1 NDN MCL1 DNM1 DNM2 PTPRZ1 IL36A PRDX6 IL36B DNM3 LIF IL36G IL11 IL13 IL16 OSMR IL31 IL34 OSM BATF MYH9 IL18RAP IL4R SOD1 IL11RA IL36RN IL4 DCTN6 DCTN5 RALA DCTN1 DCTN4 TSPAN14 CBL TLR8 CNPY3 LGMN HERC2 LTA4H ZBP1 NLRP4 DTX4 DUSP4 SP100 DUSP3 VRK3 DUSP6 DUSP7 MAPK7 CAMK2B CAMK2D CAMK2A CAMK2G CREB1 MT2A S100A1 HMGB1 HSPA9 TIRAP HSPA5 mip BTK porB TLR6 HSPA6 CD36 OSBPL1A SLC27A2 EIF4A2 IFITM3 EIF4A1 IFITM1 IFITM2 IFIT5 IFI35 IFIT1 IFI30 IFIT3 ICAM1 IFIT2 TRIM29 TRIM26 TRIM22 GBP6 GBP5 RSAD2 IFI27 TRIM17 PDE12 TRIM14 TRIM10 HLA-DQA2 HLA-DQA1 EGR1 HLA-DRB5 HLA-DRB4 BST2 HLA-DRB3 HLA-DRB1 TRIM8 TRIM6 NFKBIA RELA TRIM5 TRIM2 NFKB2 TRIM3 ARIH1 HLA-DPA1 HLA-DQB2 HLA-DQB1 RNASEL IFI6 gag FLNB HLA-DPB1 MID1 VCAM1 ISG20 HLA-DRA XAF1 EIF4G3 EIF4G2 CIITA EIF4E3 PPP3CA OASL TRIM68 PPP3CB TRIM62 MAP3K7 PPM1B OAS1 IRF4 OAS2 OAS3 IRF8 IRF5 PPP3R1 IRF6 USP41 EIF4E2 IRF9 SAMHD1 TRIM46 TRIM48 NFATC1 GBP2 FCGR1B GBP1 GBP4 GBP3 TRIM45 MX2 SDCBP MX1 FYN TRIM35 TRIM38 PAK3 ABCE1 TRIM31 TRIM34 CDA FRMPD3 GMFG ABCA13 NHLRC3 MCEMP1 ARMC8 SCAMP1 RNASE2 UNC13D FLG2 PADI2 A1BG CFP PLAC8 CRACR2A PRDX4 S100A11 FUCA1 PA2G4 AZU1 HRNR TCN1 TOLLIP SERPINA3 PYGB PIGR SIGLEC9 LPCAT1 PYGL OLR1 SERPINB3 SERPINB1 NFAM1 PGAM1 TMC6 SERPINB6 PLEKHO2 SERPINB10 SERPINB12 GRN ASAH1 METTL7A AGA AGL ERP44 LRG1 YPEL5 SIGLEC5 GHDC TMEM179B RAB3D HP EPX RAB44 LAMP1 CLEC5A LAMP2 TOM1 KCMF1 IST1 OLFM4 ILF2 ACLY CLEC4C CLEC4D RAB37 DSC1 ARL8A BRI3 UBR4 RAB4B PTPRB NIT2 SNAP25 ITGAM ITGB2 FCAR ALAD FCGR3B GM2A ITGAX ACP3 PGM1 RNASET2 NDUFC2 PKM DNAJC5 TMBIM1 CANT1 FGL2 RAB24 CPPED1 PFKL CHIT1 MGAM VAPA MNDA FOLR3 VPS35L CALML5 ANPEP CPNE1 CPNE3 GOLGA7 ARSA C6orf120 KRT1 MIF SLPI CRISPLD2 TMEM63A ELOB MMTAG2 ELOC SYNGR1 COMMD9 ARSB VAT1 PTPRN2 SIGLEC14 STK11IP PRG2 NBEAL2 PRG3 BST1 CYSTM1 ORM1 PTPRJ ORM2 GLIPR1 ACTR1B CTSH CD33 LRRC7 CD53 MANBA FCER1G MME GAA NME2 COMMD3 CEACAM3 RAP2C TTR CEACAM1 RAP2B CEACAM6 ALDOC CEACAM8 CD47 ALDOA DNASE1L1 CSTB CD63 LILRA3 PGRMC1 CREG1 ORMDL3 CD58 LAIR1 GCA PTGES2 APEH HUWE1 LILRB2 NUP107 LILRB3 NUP188 SVIP QPCT CD68 SRP14 PLAU COTL1 SIRPA ENPP4 OSTF1 CHRNB4 CD93 CD300A IRAG2 NUP210 ATAD3B OSCAR NUP93 DOK3 PPIA ADGRG3 VCP CNN2 POM121 NUP205 DPP7 ALDH3B1 GGH ADA2 DNAJC13 SELL TARM1 AAAS MAN2B1 DEGS1 NUP160 MS4A3 POM121C DDX3X TNFAIP6 NUP85 TPR CRISP3 NUP88 SIRPB1 HEBP2 NUP155 HK3 ADGRE5 NAPRT NUP153 ADGRE3 HGSNAT DYNLT1 ATP6AP2 PLAUR CHI3L1 PDXK CLEC12A MVP AGPAT2 TMEM30A CMTM6 PDAP1 GALNS PTX3 S100P GLA NUP62 NDC1 NUP133 NUP50 NUP54 UBE2B NUP42 NUP43 RAE1 RANBP2 TAP2 NUP35 TAP1 CD207 SEC61A2 NUP37 MRC2 SEC61A1 SEC61G SEC61B TAPBP VAV3 RHOG VAV1 ELMO2 PLD1 RNF41 INPPL1 IQGAP2 IL5RA CSF2RB IL2RG CSF2RA IL5 IL2RB IL3RA RIPK3 DHX9 NFKB1 NKIRAS1 NKIRAS2 TLR3 NFKBIB HSP90AB1 HSPA1B IL23A IL23R STAT4 IL12B TYK2 IL12RB1 ARPC1B ACTG1 CFL1 LYN YES1 LIMK1 PTK2 CDC20 DGAT1 FABP5 SHC1 PIK3CA PLCG1 SOS1 NEU1 CTSA GLB1 ELMO1 CRK HIF1A SOCS3 PTPN1 FOXO1 AMPD3 APRT PNP STAT5A STAT5B CSH1 PRL PRLR GHR GH1 NOD1 NOD2 AGER IRAK1 IRAK2 S100A12 RIPK2 S100B TRAF6 UBE2N TAB3 TAB2 TAB1 UBE2V1 LPO MPO KPNA7 KPNA4 KPNA5 KPNA2 KPNA3 EIF2AK2 AAMP MEF2A MEF2C ELK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 STX1A GRB10 TRIB3 FBXL7 FBXL18 PML ATF2 UNC93B1 SLC2A5 PANX1 TNF hly RBCK1 SQSTM1 NANOG CASP2 SOS2 BIRC2 BIRC3 CEBPD MRE11 MAPKAP1 MAP2K6 TRAC CD3E GRAP2 TRBC1 ICOSLG PDCD1LG2 CD274 TRBV12-3 TRAV29DV5 TRBV7-9 BTLA PRR5 TRAV19 TRAV8-4 PDPK1 RNF34 RICTOR CUL2 VHL CARD9 IL27 JUN IL27RA IL12A SOD2 LMNB1 SERPINB2 LCP1 IL6ST EBI3 BOLA2B HNRNPDL IL12RB2 PDCD4 CRLF1 TXN CDK13 GPI FOS BCL6 PTEN CASP1 APAF1 BIRC5 NLRC4 CYFIP2 AHCYL1 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 TXNIP V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 MEFV PLCG2 HMOX1 GSDMD V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV IL10 SIKE1 V5-4 V5-1 SYK IL18 V5-6 HCK IL1A IL1B IGLV3-19 WAS HSP90AA1 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 ACTR1A MYO9B PPP2R1A IGLV BTRC PRKACA MUC5AC IGHG3 PYCARD CEP290 IGHG4 IGHG1 IGHG2 V3-4 SKP1 V3-3 V3-2 IGKV1D-39 IGKV1D-33 FBXW11 TUBB MUC12 MUC15 MUC3A IGHV4-59 MUC3B DYNLL1 GPR84 IGLV2-11 NCKIPSD MUC16 MUC17 MUC19 IGLV1-40 MUC20 IGLV1-47 MUC21 IGLV6-57 IGLV2-14 IGLV1-44 UBA52 MUC5B IGKV3-15 NLRP3 IGKV3-11 DYNC1I2 V2-8 DCTN2 DCTN3 IGLV7-43 IGKV1D-16 CUL1 IGKV1D-12 IL6 IGLV1-51 IGLV2-23 UBB IGKV3-20 IGHV4-34 IGHV1-2 IGHV4-39 UBC FCGR3A PSTPIP1 RPS27A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 DYNC1H1 V1-7 V1-5 V1-3 TUBB4B IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A WASF3 IGHV3-53 RORA IGLC7 MYO10 IGKV5-2 IGLC6 PIAS1 FCGR2A SUGT1 FLT3 SUMO1 B2M HLA-A CD8B LCK CD28 MUC1 POLR2E POLR2F MUC2 POLR2H POLR2K MUC7 POLR2L MUC4 MUC6 UL83 NEDD4 MKRN1 STUB1 FRK ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 TALDO1 UBE2S CDC26 CDC16 DERA CDC27 ANAPC4 PGM2 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 HVCN1 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 TNIP2 PAK2 PSMB8 PSMB9 PRKCE SEM1 PSMC5 PTPN12 PSMC6 RAP1GAP2 PSMC3 RASGRP2 PSMC4 RASGRP1 CUL5 PSMC1 RAP1GAP RAP1B PSMC2 RAP1A TNFRSF6B RAF1 EDA SIPA1 TNFRSF13B RAPGEF3 TNFRSF11B RAPGEF4 EDA2R TNFSF13B MUCL1 TNFSF11 TNFRSF17 TNFRSF8 TNFRSF14 TNFRSF4 TNFSF18 EDARADD TNFSF14 TNFSF15 CD70 TNFRSF18 TNFRSF9 TNFSF13 TNFRSF1B TNFRSF1A EDAR TNFSF6 TNFSF4 LTA CD27 TNFSF9 TNFRSF25 UBE2Z TNFSF8 CASP8 UBE2L3 UBE2Q2 RIPK1 TRAF2 UBE2E3 FADD CDC34 UBE2R2 APP UBA6 BCL10 UBE2J2 NEDD4L UBE2H UBE2G1 UBE2A UBE2G2 UBE2W C3AR1 UBA1 HMOX2 FPR1 FPR2 C3 C5 WWP1 ATP8A1 CCR1 PPBP ATP11B ATP11A CCR6 CCR5 SLC15A4 CCR2 ATP8B4 ANXA1 TCIRG1 F2 CUL7 TRPC1 OPRD1 CCL11 PTAFR CXCR1 CXCR2 CCL19 CCL22 ATP6V1E1 CCL20 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 LRR1 CCNF SAA1 FBXO7 ATP6V0D1 FBXO9 ATP6V0D2 WSB1 FBXO2 TRPM2 ATP6V0A2 ATP6V0A4 FBXL8 FBXL4 ATP6V1C1 ATP6V0A1 ATP6V1C2 GAN KLHL2 KLHL3 KLHL9 SPSB2 SPSB1 KBTBD6 CCL3L3 KLHL5 C5AR2 C5AR1 KBTBD8 SPSB4 FBXO27 SLC44A2 FBXO21 FBXO22 FBXW12 CISH FBXW8 FBXO17 FBXO15 ATP6V0B LMO7 FBXO10 FBXO11 KLHL41 ANO6 PSAP KCTD7 KLHL42 KLHL11 KLHL13 FBXO44 FBXO41 SOCS2 FBXO40 BTBD1 ATP6V0C SOCS6 SOCS5 UBE2F ATP6V1G3 KLHL25 ATP6V0E2 ZBTB16 CXCL10 KLHL21 KLHL22 BTBD6 FBXO30 FBXO31 KLHL20 KBTBD13 CXCL8 ASB13 ASB14 ASB11 RNF7 ASB12 ASB17 ASB18 CXCL1 FBXL22 FBXL21P ASB15 ASB16 FBXL20 CXCL2 ASB10 ATP6V1A FBXL19 FBXL15 FBXL16 FBXL13 FBXL14 FBXL12 ATP6V1D ASB8 ATP6V1F ASB9 ASB6 OPRM1 ASB7 ASB4 ASB5 ASB2 ASB3 ASB1 SLC2A3 CA1 DHX58 TKFC CBLB DCAF1 HERC4 RNF115 HERC3 ATP6V1B2 RNF114 HERC1 ATP6V1B1 CCL5 HERC6 CCL4 RNF126 HECW2 CCL3 CBLL2 TRIM11 S1PR1 ANAPC13 CCL2 UBE2J1 RNF217 HACE1 MEX3C UBAC1 DZIP3 RNF220 DET1 CAND1 LRSAM1 TRIM9 STOM TRIM4 ARIH2 RNF144B RNF138 POMC RNF130 RLIM TRIP12 UBE2D4 UBE3C UBE3D LTN1 RNF19B UBE3A UBE3B NPEPPS RNF19A AREL1 UBE2E2 UBE4A TRAIP UBA5 CDH1 UBR2 RNF111 UBR1 LONRF1 GLMN UBOX5 CAPN1 UBE2U PRSS2 RNF182 UBE2O TPP2 BLMH TRIM71 ADAM10 RNF14 UFL1 UBE2V2 UBE2Q1 TRIM69 ADAM17 UNKL DTX3L PJA2 PJA1 ADAM8 TRAF7 THOP1 TRIM50 MGRN1 RNF6 PSEN1 RNF4 RCHY1 ZNRF1 ZNRF2 NCSTN HECTD1 HECTD2 HECTD3 TRIM41 ERAP2 ELANE RNF25 ERAP1 TRIM39 LNX1 TRIM36 GSDME TRIM37 IL1RL2 EIF4A3 IL1RAPL1 IL1F10 CTSS IL9 IL9R MMP25 TEC CTSL CASP3 CTSK TIMP2 CTSG TIMP1 CTSD CTSB MMP1 MMP2 MMP3 MMP8 MMP9 CD44 LAMA5 SOCS1 IFNG IFNGR1 IFNGR2 JAK1 PITPNA BCL2 BCL2L1 CRCP CGAS DDX41 LRRFIP1 TRIM21 PGLYRP4 IRF7 PGLYRP3 TRIM56 PRKDC DEFB105B PGLYRP2 NLRC3 LEAP2 IFI16 DEFB1 DHX36 CLU STAT6 XRCC6 HTN1 DEFB109B POLR3GL XRCC5 HTN3 S100A7A TREX1 POLR3A BPIFA1 GNLY STING1 POLR3B BPIFA2 POLR3C EPPIN PGLYRP1 POLR3D POLR3E ATP7A PRSS3 POLR3F CAMP POLR3G POLR3H DEFB106B POLR3K DEFB119 TRIM32 DCD DEFB118 IRS1 DEFB117 DEFB116 PIK3R4 SLC11A1 IRS2 DEFB115 PIK3CB DEFB114 RNASE6 FGF2 DEFB113 DEFB112 RNASE3 DEFB110 TLR1 BPI PRTN3 THEM4 DEFB130A DEFB130B DEFB4B S100A9 FLT3LG S100A8 TLR2 GAB2 LTF S100A7 REG3A DEFB103B TLR9 DEFB129 PIK3C3 DEFB131A DEFB128 DEFB127 DEFB126 ITLN1 DEFB125 IP6K2 DEFB124 DEFB123 REG3G KEAP1 DEFB121 DEFB107B ART1 PDZD11 SSA1 RNASE8 SSA2 RNASE7 RNF123 DEFA1B PI3 CHGA DEFB104B DEFA6 SIAH2 DEFA4 DEFA5 PLA2G2A DEFB136 DEFA3 DEFB135 DEFB134 DEFB133 env DEFB108B LYZ DEFB132 TOMM70 DEFB108C ATOX1 BPIFB2 CD4 BPIFB1 BPIFB4 PRKN BPIFB6 SEMG1 LCN2 HSPA8 CLTC WASL PIK3R1 IQGAP1 SH3RF1 CDC42 PAK1 SPTAN1 NCK1 YWHAB AKT1 NUP214 PRKCD USP18 YWHAZ CLEC10A MAPKAPK2 ICAM2 ICAM3 CLEC4A CLEC4E CARD11 CLEC7A NFATC3 CLEC6A MALT1 MAPK14 RASGRP4 MAPK11 PRKCQ EIF4G1 HSPA1A CDKN1A CDKN1B IDH1 TP53 PRKACG PRKACB RBX1 KIF3A CASP4 PELI1 ACAA1 JAK3 ITCH IL6R IL1R1 TLR7 IFNAR1 STAT2 IMPDH1 IMPDH2 PDCD1 IL1RL1 IL33 CCT2 ROCK1 CUL3 MRC1 RBBP6 VIM HRAS NRAS KBTBD7 CFD GZMM RAC2 CFB TGFB1 ICAM4 PIK3R3 SMURF1 ICAM5 PLD2 RHOA FKBP1A LGALS3 DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 76%5693532 DNA Double-Strand Break Repair RHNO1 BLM BRIP1 KPNA2 ATRIP BRCC3 BARD1 RAD17 RAD9B BAP1 ATR RAD9A BABAM1 BABAM2 BRCA1 UIMC1 EXO1 TOPBP1 RFC5 RMI2 RFC3 RFC4 RFC2 RMI1 TOP3A WRN RBBP8 RPA1 H3-4 RPA2 RAD50 PPP4R2 TIPIN RPA3 TIMELESS MAPK8 PPP4C POLQ RAD1 POLH CLSPN ABL1 HERC2 UBXN1 TP53BP1 XRCC4 UBA52 RNF168 ABRAXAS1 UBB RTEL1 RAD52 UBC POLK POLE RPS27A BRCA2 RAD51AP1 PARP1 XRCC2 RFC1 XRCC3 PARP2 PALB2 RAD51D RAD51 MDC1 LIG3 UBE2V2 LIG4 SIRT6 PIAS4 RAD51B POLD3 CHEK2 RAD51C UBE2I POLD4 NHEJ1 CCNA2 POLD1 TDP2 CCNA1 POLD2 TDP1 RNF4 XRCC1 TP53 POLE4 ERCC4 DCLRE1C ERCC1 RIF1 CDK2 POLE2 POLE3 ATM SUMO1 SUMO2 POLL PCNA POLM H2AX RNF8 NSD2 APBB1 KDM4A MUS81 H2BC21 KDM4B SLX4 EYA1 EME1 H2BU1 EYA2 EME2 EYA3 GEN1 EYA4 SLX1B PPP5C SPIDR BAZ1B H2BC17 H2BC12 H2BC13 CHEK1 H2BC14 H2BC15 H2BC11 PAXIP1 H2BS1 PRKDC H2BC9 XRCC6 H4C9 XRCC5 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 MRE11 KAT5 NBN HUS1 UBE2N FEN1 DNA2 DEFECTIVE F8 BINDING TO THE CELL MEMBRANE%REACTOME%R-HSA-9672395.1 Defective F8 binding to the cell membrane F8 DNA REPLICATION INITIATION%REACTOME%R-HSA-68952.2 DNA replication initiation POLE4 POLE2 POLE3 POLE PRIM2 PRIM1 POLA1 POLA2 ABERRANT REGULATION OF MITOTIC CELL CYCLE DUE TO RB1 DEFECTS%REACTOME%R-HSA-9687139.2 Aberrant regulation of mitotic cell cycle due to RB1 defects CCNE2 CCNE1 CDK2 SKP2 CDKN1C RB1 CCND3 TFDP1 FZR1 CDK6 CCND2 TFDP2 CCND1 CDK4 E2F1 E2F2 E2F3 ANAPC15 ANAPC16 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 CDC16 CDKN1A CDC27 CDKN1B ANAPC4 ANAPC5 ANAPC1 INHIBITION OF NITRIC OXIDE PRODUCTION%REACTOME DATABASE ID RELEASE 76%9636249 Inhibition of nitric oxide production NOS2 PPE2 KPNB1 KPNA1 POLO-LIKE KINASE MEDIATED EVENTS%REACTOME DATABASE ID RELEASE 76%156711 Polo-like kinase mediated events CDC25C PKMYT1 EP300 RBBP4 LIN54 FOXM1 MYBL2 LIN52 WEE1 PLK1 LIN37 LIN9 CDC25A CENPF CCNB2 CCNB1 GLUTATHIONE SYNTHESIS AND RECYCLING%REACTOME DATABASE ID RELEASE 76%174403 Glutathione synthesis and recycling GGT3P GGCT GCLC CNDP2 GCLM OPLAH CHAC2 GSS CHAC1 GGT5 GGT1 GGT7 GGT6 DEFECTIVE BASE EXCISION REPAIR ASSOCIATED WITH NEIL3%REACTOME%R-HSA-9629232.2 Defective Base Excision Repair Associated with NEIL3 NEIL3 TRANSPORT OF THE SLBP INDEPENDENT MATURE MRNA%REACTOME DATABASE ID RELEASE 76%159227 Transport of the SLBP independent Mature mRNA NUP42 NUP210 NUP43 RAE1 RANBP2 NUP93 POM121 NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 EIF4E NCBP1 NUP214 NUP153 NCBP2 NXF1 SEC13 NUP62 NDC1 ALYREF NUP133 NUP107 NUP188 NUP50 NUP54 ACTIVATION OF C3 AND C5%REACTOME%R-HSA-174577.3 Activation of C3 and C5 C3 CFB C5 C4A C4B_2 C2 UPTAKE AND ACTIONS OF BACTERIAL TOXINS%REACTOME%R-HSA-5339562.3 Uptake and actions of bacterial toxins SYT2 SYT1 botG tetX botE cya botD lef botA pagA botB GUCY2C PDZD3 TXNRD1 sta1 VAMP2 HA-33 HBEGF MAP2K1 CD9 MAP2K2 PDCD6IP MAP2K4 HSP90AA1 SNAP25 MAP2K7 STX1B ntnha botF SV2C STX1A SV2B SV2A VAMP1 ha17 EEF2 ha70 FURIN CALM1 HSP90AB1 TP53 REGULATES METABOLIC GENES%REACTOME%R-HSA-5628897.4 TP53 Regulates Metabolic Genes TP53 GPI COX7B COX7C COX8A TXNRD1 GPX2 COX5B COX5A AGO3 AGO4 AGO1 TIGAR AGO2 YWHAQ SFN COX6C LRPPRC YWHAH TACO1 COX6A1 SESN3 SESN2 G6PD COX6B1 PRKAB2 YWHAE COX19 PRKAA2 PRKAG1 COX16 COX18 PRKAG2 PRKAB1 COX11 PRKAG3 COX14 YWHAG CYCS GLS COX20 COX4I1 PTEN RRM2B PRKAA1 NDUFA4 RPTOR YWHAB AKT2 MLST8 SLC38A9 AKT1 TSC2 TSC1 YWHAZ MTOR RRAGA RRAGC PRDX2 RHEB RRAGB PRDX1 RRAGD LAMTOR2 TNRC6C LAMTOR1 MOV10 LAMTOR4 LAMTOR3 LAMTOR5 TNRC6A MT-CO1 TNRC6B COX7A2L SCO1 SCO2 DDIT4 MT-CO2 MT-CO3 TP63 TXN SURF1 AKT3 GLS2 PROCESSING AND ACTIVATION OF SUMO%REACTOME%R-HSA-3215018.2 Processing and activation of SUMO SENP5 SENP2 SENP1 RWDD3 SUMO1 SUMO3 UBA2 UBE2I SUMO2 SAE1 LINIFANIB-RESISTANT FLT3 MUTANTS%REACTOME DATABASE ID RELEASE 76%9702998 linifanib-resistant FLT3 mutants FLT3 LOSS OF FUNCTION OF MECP2 IN RETT SYNDROME%REACTOME DATABASE ID RELEASE 76%9005891 Loss of function of MECP2 in Rett syndrome NCOR1 HDAC3 CAMK4 HDAC1 PRKACA GPS2 CALM1 TBL1XR1 NCOR2 SIN3A TBL1X FCGAMMA RECEPTOR (FCGR) DEPENDENT PHAGOCYTOSIS%REACTOME%R-HSA-2029480.1 Fcgamma receptor (FCGR) dependent phagocytosis V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV CYFIP1 V5-4 NCKAP1 V5-1 ARPC4 SYK FGR ARPC5 FYN VAV3 V5-6 HCK MAPK1 BRK1 VAV1 IGLV3-19 ITPR1 ARPC2 ELMO2 ITPR2 ARPC3 MAPK3 ITPR3 PLD1 WAS HSP90AA1 IGLV3-25 PLPP5 IGLV3-27 PLPP4 IGKC IGLV3-21 V4-6 V4-2 V4-1 MYH9 IGKV1-5 ACTR2 MYO9B WASL PIK3R1 VAV2 IGLV IGHG3 CDC42 IGHG4 PAK1 IGHG1 IGHG2 V3-4 V3-3 V3-2 PIK3R2 IGKV1D-39 HSP90AB1 IGKV1D-33 NCK1 ABL1 IGHV4-59 NCKAP1L WASF1 IGLV2-11 NCKIPSD WASF2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MYO1C IGKV3-15 NF2 BAIAP2 IGKV3-11 V2-8 ABI2 IGLV7-43 ARPC1B ABI1 ACTG1 IGKV1D-16 CFL1 PLD4 IGKV1D-12 PLD3 LYN YES1 IGLV1-51 IGLV2-23 PRKCD IGKV3-20 LIMK1 PTK2 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 FCGR1A WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 FCGR2A PIK3CA PLCG1 PLA2G6 MYO5A BTK ACTB CD3G ARPC1A ELMO1 CRK CYFIP2 AHCYL1 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 PIK3CB IGHV3-9 PRKCE IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 PLD2 V1-16 V1-13 IGHV1-69 PLCG2 HEMOSTASIS%REACTOME DATABASE ID RELEASE 76%109582 Hemostasis JAM2 V1-20 SLC3A2 JAM3 PRKCB FN1 IGKV2D-40 IGHV3-11 IGHV3-13 ACTN1 F8 IGHV1-46 IGHV V5-4 V5-1 APBB1IP SYK FYN V5-6 MAPK1 IGLV3-19 ITGA3 MAPK3 GAS6 GNAI3 KIF28P KDM1A NOS2 JMJD1C GNAI1 GNAI2 DOCK11 HGF IGLV3-25 KIF5C KIF5B A1BG IGLV3-27 KIF5A MYB IGKC IGLV3-21 RAB5A KIF21A KIF21B V4-6 KIFAP3 V4-2 IFNA13 V4-1 IFNA14 IFNA16 IGKV1-5 IFNA17 HBE1 PPP2R1A KIF16B KIF20A SERPINA3 KIF20B ZFPM1 IFNA10 IGLV PRKACA GATA6 GATA5 AK3 GATA4 OLR1 GATA3 KLC1 GATA2 V3-4 GATA1 V3-3 V3-2 PHF21A SERPINB6 IGKV1D-39 KLC4 IGKV1D-33 KLC3 KLC2 KIF3B MICAL1 ABL1 PRKCG KIF3C IFNA21 CARMIL1 NFE2 L1CAM IGHV4-59 CBX5 HBG2 HBG1 EHD1 IGLV2-11 EHD2 EHD3 TUBA4A IGLV1-40 KIF18A IGLV1-47 KIF18B CDK5 IGLV6-57 ITGA2B IGLV2-14 KIF4B MAFG LAMP2 IGLV1-44 KIF4A MAFF IGKV3-15 MAFK RCOR1 IGKV3-11 DOCK6 V2-8 IFNA5 DOCK5 IFNA4 IGLV7-43 DOCK4 IGKV1D-16 IFNA7 IGKV1D-12 DOCK3 IFNA6 IGLV1-51 DOCK9 IGLV2-23 DOCK8 IGKV3-20 DOCK7 IFNA2 PRKAR2B IGHV4-34 HBB IGHV1-2 KIF12 ITGAM IGHV4-39 HBD ITGB2 KIF11 IFNA8 KIF15 IGKV2-29 ITGA10 AKAP10 IGKV2-28 KIF19 IGLC3 CAPZB ITGAX IGLC1 SIN3A IGLC2 V1-9 KIF13B ITGB3 HMG20B V1-7 V1-5 KIF1C V1-3 KIF1B ITGAV RAC1 KIF1A JAK2 ITGA2 IGKV3D-20 ITPK1 ITGA1 KIF25 ITGA5 KIF23 KIF22 IGKV2-30 RBSN IGHV2-70 IGHV2-5 KIF6 IGHV3-48 KIF27 RAD51B IGLV3-1 KIF9 RAD51C KIF2A IGKV1-39 KIFC2 IGKV1-33 KIFC1 IRF1 IGHV3-53 IRF2 KIF2C IGLC7 MIF KIF2B DOCK2 IGKV5-2 DOCK1 IGLC6 AKAP1 MFN1 MFN2 SH2B3 SH2B2 SH2B1 IFNB1 CABLES1 LCK CABLES2 CENPE TLN1 PFN1 WEE1 KIF26A ACTN2 KIF26B GRB7 CAPZA1 ORM1 CAPZA2 VPS45 ORM2 FCER1G CAP1 CEACAM3 CEACAM1 MPL THPO LCP2 CEACAM6 H3-3B CEACAM8 H3C8 CD47 ALDOA CD63 CD58 DOK2 PLAU APOA1 SIRPA HDAC2 HDAC1 H3C15 APLP2 PPIA SCG3 SELL CD9 APOOL CALU QSOX1 AHSG PLAUR ALB PRKCE RASGRP2 RASGRP1 RAP1B RAP1A RAF1 RAPGEF3 RAPGEF4 SPP2 SLC7A7 SLC7A9 LEFTY2 SLC16A1 APP VAV3 RHOG VAV1 GNG10 CYB5R1 GNG12 GNG11 GNG13 GNB2 GNAQ GNB1 GNB4 GNB3 FLNA GNB5 GNGT1 GNGT2 SLC7A6 SLC7A8 GNA14 GNG3 GNA15 GNG2 GNG5 GNG4 GNG7 GNA11 GNG8 PPBP SLC16A8 CFL1 LYN TNFRSF10B TNFRSF10A YES1 SLC16A3 TNFRSF10D PTK2 CSK VEGFB PCDH7 VEGFC VEGFD VEGFA SDC4 SDC2 SDC3 GPC1 MGLL F2 SHC1 PIK3CA PLCG1 SOS1 SDC1 SERPINA1 P2RY12 IGF1 IGF2 F2RL2 PF4 CRK F2RL3 PTPN1 BCAR1 IGHM F2R STX4 SPN PPIL2 SLC7A11 SLC7A10 KNG1 ITGA6 TBXA2R PSAP ANGPT1 TEK ANXA2 GNA13 AAMP ITGB1 VCL ATP1B3 ATP1B2 ATP1B1 DOCK10 PDGFB ARRB1 ARRB2 PTGIR ADRA2C ADRA2B VAV2 ADRA2A ABCC4 PIK3R2 POTEKP ISLR HABP4 FAM3C CHID1 SERPINF2 ACTN4 RACGAP1 GTPBP2 SYTL4 P2RY1 TMX3 CD109 SELENOP TAGLN2 NHLRC2 TEX264 STXBP2 ENDOD1 APOH VTI1B RARRES2 CAV1 CYRIB MANF SELP SCCPDH MAGED2 HRG FERMT3 LGALS3BP ECM1 WDR1 PLEK OLA1 IGHA1 CTSW IGHA2 SERPINA4 TMSB4X TIMP3 JCHAIN PHACTR2 SRGN ANXA5 MMRN1 TOR4A ITIH4 ITIH3 CLEC3B CDC37L1 BSG LY6G6F LHFPL2 PCYOX1L ITGAL ITGA4 PLAT SRC SERPINE1 STXBP3 A2M TTN RAB27B TF TIMP1 MAG MMP1 CD44 SERPINE2 PLG SERPINC1 PROS1 F13A1 PRCP TFPI SERPINA5 THBD C1QBP PF4V1 CD177 FGB FGA SERPIND1 F10 VWF KLKB1 GP1BB F12 F11 FGG GP1BA F3 GP5 F5 CLU F7 PROCR GP9 PROC F9 SERPING1 F13B INPP5D PIK3CB PRTN3 GUCY1B2 GUCY1B1 ATP2A3 ATP2A2 ATP2A1 SLC8A1 SLC8A2 PPP2R1B PPP2R5E PRKG2 NOS1 TRPC7 GUCY1A2 GUCY1A1 TRPC6 TRPC3 IRAG1 PPP2R5B PLA2G4A BRPF3 PPP2R5A PPP2R5D CEACAM5 PPP2R5C FGR STIM1 KCNMA1 PECAM1 ORAI2 ORAI1 PDE9A THBS1 PDE1B PDE1A TSPAN7 ITPR1 ITPR2 ITPR3 SRI LRP8 PPP2CA PPP2CB PDE11A KCNMB1 KCNMB2 KCNMB3 KCNMB4 APOB NOS3 PDE2A PDPK1 ATP2B4 PICK1 ATP2B3 ATP2B2 PTPN11 ATP2B1 SOD1 PAFAH2 P2RX7 SLC8A3 P2RX6 PIK3R1 PDPN P2RX5 MPIG6B GP6 P2RX4 LAT PDE10A CDC42 P2RX3 P2RX2 P2RX1 PTPN6 CALM1 EGF TREM1 AKT1 PRKCD PRKCA YWHAZ SERPINB2 DGKG DGKE DAGLA DGKD DGKB DGKA ABHD6 ABHD12 PRKCH DGKZ MAPK14 DGKQ PRKCQ CLEC1B DAGLB DGKK DGKI DGKH SERPINB8 S100A10 TGFB2 TGFB3 TP53 CDK2 PRKACG PRKACB SLC7A5 PRKAR1B HSPA5 PRKAR1A RHOB KIF3A GNA12 CD36 PRKAR2A GNAS PIK3R6 PIK3CG PIK3R5 VPREB3 VPREB1 CXADR PSG1 PSG3 PSG2 FCAMR PSG9 PSG8 PSG5 PSG4 PSG7 PSG6 GYPA GYPC GYPB CD99L2 GLG1 piiC PF3D7_1301600 CD48 SELPLG EPCAM CD74 ebl-1 IGLL1 CD84 SIRPG GRB14 JAML PSG11 CD99 SELE ESAM opaD PDE5A opaE opaF opaG opaA opaB IGHV3-23 opaC opaH opaI IGLV2-8 opaJ IGKV1-16 opaK GNAT3 ANGPT4 HRAS IGKV1-17 ANGPT2 IGKV1-12 MERTK IGHV3-7 CD2 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 NRAS V2-15 V2-19 CFD IGKV2D-28 IGKV4-1 RAC2 IGHV7-81 SPARC TGFB1 V1-11 PIK3R3 IGKV2D-30 F11R V1-16 PRKCZ V1-13 IGHV1-69 RHOA PLCG2 METALLOTHIONEINS BIND METALS%REACTOME%R-HSA-5661231.2 Metallothioneins bind metals MT2A MT1A MT1F MT1G MT1H MT1B MT1E MT4 MT3 MT1M MT1X SMAC, XIAP-REGULATED APOPTOTIC RESPONSE%REACTOME DATABASE ID RELEASE 76%111469 SMAC, XIAP-regulated apoptotic response XIAP CASP9 APAF1 CASP7 CASP3 DIABLO CYCS MEIOTIC RECOMBINATION%REACTOME DATABASE ID RELEASE 76%912446 Meiotic recombination BLM CDK2 ATM MLH1 BRCA1 H2AX H2AB1 H2AC19 H2AC14 PRDM9 H2BC21 H2BU1 H3-3B H3C8 TOP3A H2AC8 H2AC6 H2AC7 RBBP8 H2BC17 H2BC12 H2BC13 RPA1 H3-4 H2BC14 RPA2 H2AJ H2BC15 RAD50 RPA3 MSH4 H2BC11 MSH5 SPO11 H3C15 TEX15 DMC1 H2BS1 PSMC3IP MND1 MLH3 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 H2BC1 H2AC20 CDK4 BRCA2 MRE11 RAD51 NBN RAD51C NEGATIVE REGULATION OF TCF-DEPENDENT SIGNALING BY WNT LIGAND ANTAGONISTS%REACTOME%R-HSA-3772470.2 Negative regulation of TCF-dependent signaling by WNT ligand antagonists SFRP1 SFRP2 WIF1 WNT3A WNT5A SOST WNT4 KREMEN1 KREMEN2 LRP5 DKK1 DKK2 WNT9A DKK4 LRP6 TERMINAL PATHWAY OF COMPLEMENT%REACTOME%R-HSA-166665.3 Terminal pathway of complement C6 C7 C9 CLU C5 C8B C8A C8G COPII-MEDIATED VESICLE TRANSPORT%REACTOME%R-HSA-204005.4 COPII-mediated vesicle transport COL7A1 TRAPPC2 ANKRD28 TRAPPC3 LMAN2L SEC16B TGFA F8 SCFD1 TRAPPC1 TRAPPC4 SEC16A TRAPPC5 SEC31A TRAPPC9 CNIH1 CNIH2 CNIH3 MCFD2 CTSZ TRAPPC6A PPP6C PPP6R1 TRAPPC6B PPP6R3 TMED2 GORASP1 CTSC SERPINA1 SEC13 AREG NAPA NAPB GOSR2 SEC22B SEC22A STX17 SEC22C RAB1A SEC23A NAPG RAB1B LMAN1 CD59 CSNK1D YKT6 SEC24B SEC23IP SEC24A SAR1B F5 USO1 SEC24D SEC24C FOLR1 LMAN2 BET1 STX5 GOLGA2 TRAPPC10 NSF TRAPPC2L TBC1D20 LMAN1L TMED10 GRIA1 TFG PREB PRE-MRNA SPLICING%REACTOME%R-HSA-72163.2 pre-mRNA splicing CSTF2 PABPN1 CPSF1 CPSF4 HSPA8 DHX9 DDX5 HNRNPU HNRNPR CCAR1 SNRPD2 SNRPD1 SNRPD3 SRRM2 CRNKL1 ELAVL1 CD2BP2 SF1 CSTF3 SNU13 NCBP1 PCBP1 NCBP2 CSTF1 SYMPK PRPF38A HNRNPL HNRNPM HNRNPK HNRNPF SUGP1 PQBP1 PCF11 DHX15 DHX16 PRPF40A WDR33 GCFC2 HNRNPH1 HNRNPH2 SF3B4 SF3B5 SF3B2 SF3B3 SF3B6 SRRT SRSF10 SF3A3 SF3A1 SF3A2 NUDT21 PHF5A HNRNPA2B1 PRPF31 CWC25 CWC27 EFTUD2 CWC22 PAPOLA MTREX TXNL4A SNRPN SNW1 WBP11 PRPF4 PRPF6 HNRNPUL1 PRPF3 EIF4A3 SNRPG CASC3 SNRNP27 PPIH MAGOH SNRPE SNRPF POLR2A SNRPC POLR2B SNRNP200 POLR2C CDC40 SNRPA POLR2D SNRPB POLR2E PRPF8 POLR2F POLR2G FUS POLR2H CPSF3 POLR2I CPSF2 POLR2J SRSF2 CWC15 POLR2K SRSF3 LSM5 POLR2L SRSF4 LSM4 SRSF5 LSM3 SRSF6 LSM2 SRSF7 CHERP GTF2F1 LSM8 SLU7 SRSF9 LSM7 LSM6 GTF2F2 DDX46 RBM8A DDX42 PPWD1 YBX1 SRSF1 USP39 U2AF1 ELAVL2 U2AF1L4 PTBP1 PCBP2 SART1 U2AF2 DHX38 SNRNP70 SRSF11 RBM5 ALYREF BCAS2 UPF3B CTNNBL1 MAGOHB RBM17 BUD31 RNPS1 TFIP11 PLRG1 SYF2 SNRPA1 DNAJC8 RBM22 WBP4 DDX23 PRCC CSTF2T PUF60 FIP1L1 SNRPB2 HNRNPA1 SMNDC1 HNRNPA0 HNRNPA3 PPIL1 GPKOW CDC5L U2SURP CPSF7 SNRNP40 SF3B1 PPIL3 PPIL4 PPIL6 SRRM1 TRA2B HNRNPC RBMX ISY1 PRPF19 AQR PPIE XAB2 CLP1 ACTIVATION OF NF-KAPPAB IN B CELLS%REACTOME DATABASE ID RELEASE 76%1169091 Activation of NF-kappaB in B cells PRKCB BCL10 BTRC NFKB1 SKP1 NFKBIB PSMD8 PSMD9 PSMD6 FBXW11 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 REL PSMD11 NFKBIE PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB IKBKB PSMB3 PSMB1 PSMF1 CHUK UBC PSMB8 NFKBIA RELA PSMB9 RPS27A SEM1 IKBKG PSMC5 CARD11 PSMC6 PSMC3 PSMC4 PSMC1 MALT1 PSMC2 MAP3K7 RETROGRADE TRANSPORT AT THE TRANS-GOLGI-NETWORK%REACTOME DATABASE ID RELEASE 76%6811440 Retrograde transport at the Trans-Golgi-Network RAB6B TGOLN2 IGF2R M6PR RABEPK VTI1A NAA30 PLIN3 NAA35 NAA38 VAMP3 NAPA NAPB STX16 NAPG STX10 VPS51 VPS53 VPS52 VPS54 VAMP4 RGP1 RAB9A TMF1 RAB9B ARFRP1 SYS1 STX6 GCC2 GCC1 GOLGA4 RIC1 GOLGA1 NSF ARFIP2 RAB43 COG8 COG7 COG6 COG5 COG4 COG3 COG2 COG1 USP6NL SCOC ARL1 RHOBTB3 RAB6A DARPP-32 EVENTS%REACTOME%R-HSA-180024.3 DARPP-32 events PPP2CA PPP2CB PPP2R1B PRKAR2B PDE4B PDE4A PPP3R1 PDE4D PDE4C PPP3CC PRKACG PRKACB PPP2R5D CDK5 PPP2R1A PPP1CA PRKAR1B PPP1R1B PRKAR1A PRKACA PRKAR2A CALM1 PPP3CA PPP3CB ACTIVATION OF BIM AND TRANSLOCATION TO MITOCHONDRIA%REACTOME%R-HSA-111446.2 Activation of BIM and translocation to mitochondria BCL2L11 DYNLL1 MAPK8 APOPTOSIS%REACTOME%R-HSA-109581.3 Apoptosis GSDMD PPP3R1 TP53BP2 CASP8 TRADD RIPK1 TRAF2 FADD TP73 MAPK1 PPP1R13B YWHAQ YWHAH MAPK3 KPNA1 YWHAE KPNB1 GSN DSG2 YWHAG MAPK8 UNC5A BMF SPTAN1 UNC5B DYNLL2 CLSPN DYNLL1 ADD1 UBA52 YWHAB STAT3 TNFSF10 AKT1 TNFRSF10B TNFRSF10A DSP PRKCD UBB PTK2 YWHAZ TFDP1 UBC LMNB1 TFDP2 CDH1 RPS27A E2F1 DSG1 PRKCQ AKT3 BCL2L11 TP53 CDKN2A BBC3 BCAP31 CTNNB1 GSDME TJP2 HMGB1 BID SFN CASP3 BAK1 GZMB MAGED1 PMAIP1 DCC PSMD8 PSMD9 CYCS PSMD6 PSMD7 PSMD4 OPA1 C1QBP MC159L PSMD5 ORF71 PSMD2 TICAM2 BCL2 PSMD3 LY96 BCL2L1 PSMD1 FASLG CASP6 TICAM1 PSMA5 APAF1 PSMA6 FAS CD14 ARHGAP10 PSMA3 TLR4 TJP1 PSMA4 PSMA1 PSMA2 ROCK1 PSME3 PSME4 PSME1 PSME2 BIRC2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 XIAP BAX PSMD13 AKT2 OMA1 PSMA7 PSMB10 VIM PSMA8 APIP PSMB6 PSMB7 BAD PSMB4 PSMB5 DAPK1 PSMB2 DAPK2 PSMB3 APC DAPK3 PSMB1 PSMF1 H1-1 H1-0 PAK2 H1-3 PSMB8 H1-2 PSMB9 SEM1 H1-5 AVEN H1-4 CASP9 PSMC5 OCLN CASP7 PSMC6 PPP3CC APPL1 PSMC3 DIABLO DFFB PSMC4 DFFA UACA PSMC1 DBNL CARD8 PSMC2 NMT1 GAS2 MAPT SATB1 FNTA PLEC PKP1 BMX STK24 STK26 HMGB2 DNM1L DSG3 ACIN1 TP63 TLR3 DEFICIENCY - HSE%REACTOME%R-HSA-5602410.1 TLR3 deficiency - HSE TLR3 HYALURONAN BIOSYNTHESIS AND EXPORT%REACTOME DATABASE ID RELEASE 76%2142850 Hyaluronan biosynthesis and export HAS2 CEMIP HAS1 ABCC5 HAS3 ACTIVATION OF MATRIX METALLOPROTEINASES%REACTOME%R-HSA-1592389.2 Activation of Matrix Metalloproteinases CMA1 ELANE KLKB1 COL18A1 MMP25 MMP24 CTSK TIMP2 CTSG PRSS1 TIMP1 TPSAB1 MMP7 MMP1 MMP2 MMP3 MMP8 MMP9 MMP10 PRSS2 MMP11 MMP14 MMP13 CTRB2 MMP16 CTRB1 MMP15 MMP17 FURIN PLG SPOCK3 KLK2 TERMINATION OF TRANSLESION DNA SYNTHESIS%REACTOME DATABASE ID RELEASE 76%5656169 Termination of translesion DNA synthesis POLD2 POLE4 PCLAF USP43 POLE2 POLE3 PCNA UBA52 USP10 UBB RFC5 UBC RFC3 UBA7 POLK RFC4 POLI RFC2 TRIM25 RPS27A POLE UBE2L6 RFC1 ISG15 RPA1 RPA2 RPA3 POLD3 POLH POLD4 REV1 POLD1 HCN CHANNELS%REACTOME DATABASE ID RELEASE 76%1296061 HCN channels HCN2 HCN4 HCN1 HCN3 L1CAM INTERACTIONS%REACTOME%R-HSA-373760.2 L1CAM interactions ITGB1 CSNK2A1 SDCBP CSNK2A2 EPHB2 MAPK1 RPS6KA3 CSNK2B RPS6KA5 RPS6KA2 RPS6KA1 EZR MAPK3 DNM1 DNM2 DNM3 HSPA8 RDX MSN CLTC VAV2 ALCAM SPTB PAK1 SCN11A DPYSL2 SPTAN1 SPTBN1 SCN10A L1CAM CHL1 LYPLA2 ITGA2B KIF4B KIF4A MAP2K1 MAP2K2 ITGA10 CNTNAP1 ITGB3 ITGAV RAC1 ITGA2 ITGA1 ANK2 ITGA5 ANK3 ANK1 ITGA9 NFASC RPS6KA4 SPTBN4 SCN1B SPTBN5 SCN1A SHTN1 KCNQ2 KCNQ3 SPTBN2 LAMC1 RPS6KA6 SCN3B SCN3A DLG1 DLG3 DLG4 CD24 SCN2A SCN2B NRP1 NUMB CLTA NRP2 AP2A1 RANBP9 SCN9A CNTN2 NRCAM AP2A2 SCN8A AP2M1 NCAN LAMB1 CNTN6 CNTN1 SCN5A GAP43 DCX SCN4A SCN4B AP2S1 LAMA1 EGFR SCN7A NCAM1 AP2B1 SH3GL2 SPTA1 FLT3 SIGNALING IN DISEASE%REACTOME DATABASE ID RELEASE 76%9682385 FLT3 signaling in disease NOX4 BCL2L1 GRB2 ZMYM2 PIK3CA FLT3 SOS1 TRIP11 UBA52 UBB PIM1 STAT5A STAT5B HRAS UBC RPS27A NRAS PTPN11 MYO18A PIK3R1 FLT3LG ETV6 GAB2 CDKN1A CBL SPTBN1 SIGNALING BY RAF1 MUTANTS%REACTOME DATABASE ID RELEASE 76%9656223 Signaling by RAF1 mutants FN1 BRAF FGB FGA VWF FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 ARRB1 ARRB2 CAMK2B CSK CAMK2D HRAS CAMK2A MARK3 CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 JAK2 KSR2 CALM1 SRC DEFECTS IN BIOTIN (BTN) METABOLISM%REACTOME%R-HSA-3323169.1 Defects in biotin (Btn) metabolism PCCB ACACA MCCC2 PC PCCA HLCS BTD MCCC1 MITOCHONDRIAL IRON-SULFUR CLUSTER BIOGENESIS%REACTOME DATABASE ID RELEASE 76%1362409 Mitochondrial iron-sulfur cluster biogenesis FXN ISCA2 FDXR ISCA1 LYRM4 SLC25A28 SLC25A37 HSCB GLRX5 FDX1 FDX2 INTERACTION WITH CUMULUS CELLS AND THE ZONA PELLUCIDA%REACTOME%R-HSA-2534343.2 Interaction With Cumulus Cells And The Zona Pellucida B4GALT1 ZP1 ADAM21 ZP3 ADAM20 ZP2 OVGP1 SPAM1 ZP4 ADAM30 ADAM2 DEFECTIVE NEU1 CAUSES SIALIDOSIS%REACTOME DATABASE ID RELEASE 76%4341670 Defective NEU1 causes sialidosis CTSA NEU1 GLB1 PHOSPHOLIPASE C-MEDIATED CASCADE: FGFR1%REACTOME%R-HSA-5654219.2 Phospholipase C-mediated cascade: FGFR1 FGF23 FGF22 FGF1 FGF2 PLCG1 FGF3 FGF4 FGF6 FGF10 FGF9 FGF20 P75NTR SIGNALS VIA NF-KB%REACTOME%R-HSA-193639.1 p75NTR signals via NF-kB UBB NGF IKBKB MYD88 UBC NFKBIA SQSTM1 RELA RPS27A UBA52 IRAK1 NFKB1 RIPK2 TRAF6 PRKCI NGFR MASTL FACILITATES MITOTIC PROGRESSION%REACTOME%R-HSA-2465910.2 MASTL Facilitates Mitotic Progression PPP2CA PPP2R1A PPP2CB ARPP19 PPP2R1B ENSA CDK1 MASTL PPP2R2D CCNB1 GSD IV%REACTOME DATABASE ID RELEASE 76%3878781 GSD IV GBE1 GYS2 GYG2 MITOCHONDRIAL FATTY ACID BETA-OXIDATION%REACTOME%R-HSA-77289.5 Mitochondrial Fatty Acid Beta-Oxidation ACAD11 HADH ACAD10 ACOT9 MECR ACOT7 ACOT11 ACOT12 ACOT13 MMAA ACOT1 MMUT ACOT2 THEM5 ECHS1 DECR1 ACBD7 ACBD6 MCAT PCCA ACSF2 PCCB HADHB HADHA ACOT7L ACADL PCTP DBI MCEE ACADM ACADS NDUFAB1 THEM4 ACADVL ACAA2 ACSM3 ECI1 ACSM6 FCERI MEDIATED CA+2 MOBILIZATION%REACTOME%R-HSA-2871809.1 FCERI mediated Ca+2 mobilization V1-20 IGKV2D-40 IGHV3-11 PPP3R1 IGHV3-13 IGHV1-46 NFATC1 IGHV GRAP2 V5-4 V5-1 SYK VAV3 V5-6 VAV1 IGLV3-19 ITPR1 ITPR2 ITPR3 IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 IGKV1-5 VAV2 IGLV CALM1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 IGHV4-59 IGLV2-11 ITK IGLV1-40 IGLV1-47 TXK IGLV6-57 NFATC2 IGLV2-14 IGLV1-44 IGKV3-15 IGKV3-11 V2-8 IGLV7-43 IGKV1D-16 IGKV1D-12 LYN IGLV1-51 IGLV2-23 IGKV3-20 IGHV4-34 IGHV1-2 IGHV4-39 IGKV2-29 IGKV2-28 IGLC3 IGLC1 NFATC3 IGLC2 V1-9 V1-7 V1-5 V1-3 IGKV3D-20 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 IGHV3-53 IGLC7 IGKV5-2 IGLC6 PLCG1 IGHE SOS1 BTK TEC LCP2 AHCYL1 IGHV3-23 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 PPP3CA PPP3CB PLCG2 MEIOTIC SYNAPSIS%REACTOME%R-HSA-1221632.1 Meiotic synapsis ATR BRCA1 H2AX H2AB1 FKBP6 H2AC19 H2AC14 H2BC21 H2BU1 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 H2BC12 H2BC13 H3-4 H2BC14 POT1 H2AJ TERF2IP H2BC15 H2BC11 SYCE3 SYCE2 SYCE1 STAG3 SYCP2 SYCP1 HSPA2 SYNE2 SMC3 SYNE1 SUN2 SUN1 TEX12 SMC1B H2BS1 RAD21 REC8 H2AZ1 SYCP3 H2BC9 STAG1 H2AZ2 STAG2 H4C9 H2BC8 H2BC5 SMC1A H2BC3 H2BC1 H2AC20 LMNB1 UBE2I IRON UPTAKE AND TRANSPORT%REACTOME DATABASE ID RELEASE 76%917937 Iron uptake and transport ACO1 FTMT TCIRG1 ATP6V1G3 ATP6V0E2 HFE TFR2 TFRC ATP6V1H STEAP2 TF STEAP3 ABCG2 ATP6V1A HMOX2 LCN2 ATP6V1D ATP6V1F MCOLN1 FBXL5 SLC46A1 ATP6V1E1 ATP6V1E2 SKP1 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6AP1 GLRX3 NEDD8 ATP6V1B2 ATP6V1B1 ATP6V0D1 ATP6V0D2 SLC11A2 ATP6V0A2 ATP6V0A4 CAND1 UBA52 ATP6V1C1 ATP6V0A1 ATP6V1C2 CUL1 UBB CP FTH1 UBC RPS27A SLC40A1 SLC22A17 IREB2 HEPH ATP6V0B FTL ATP6V0C CYBRD1 HMOX1 SIGNALING BY NTRK3 (TRKC)%REACTOME%R-HSA-9034015.2 Signaling by NTRK3 (TRKC) PTPRS IRS1 HRAS NELFB PIK3CA PLCG1 SOS1 NRAS PTPRO PIK3R1 BAX SRC NTRK3 NTF3 PKA-MEDIATED PHOSPHORYLATION OF KEY METABOLIC FACTORS%REACTOME DATABASE ID RELEASE 76%163358 PKA-mediated phosphorylation of key metabolic factors PFKFB1 PRKACA MLXIPL PRKACG PRKACB SCAVENGING BY CLASS A RECEPTORS%REACTOME DATABASE ID RELEASE 76%3000480 Scavenging by Class A Receptors APOA1 FTH1 APOB MASP1 SCARA5 HSP90B1 MSR1 MARCO SCGB3A2 FTL COLEC12 APOE COL1A1 COL3A1 CALR COL1A2 COLEC11 COL4A2 COL4A1 BREAKDOWN OF THE NUCLEAR LAMINA%REACTOME DATABASE ID RELEASE 76%352238 Breakdown of the nuclear lamina CASP6 LMNB1 ROS AND RNS PRODUCTION IN PHAGOCYTES%REACTOME%R-HSA-1222556.9 ROS and RNS production in phagocytes LPO ATP6V1B2 MPO ATP6V1B1 TCIRG1 ATP6V1G3 ATP6V0D1 ATP6V0E2 ATP6V0D2 HVCN1 NOS1 ATP6V0A2 ATP6V0A4 ATP6V1C1 NCF1 NCF2 ATP6V0A1 ATP6V1H ATP6V1C2 NCF4 ATP6V1A NOS2 SLC11A1 NOS3 ATP6V1D ATP6V1F CYBB CYBA ATP6V0B RAC2 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 ATP6V0C ACYL CHAIN REMODELLING OF PI%REACTOME%R-HSA-1482922.2 Acyl chain remodelling of PI PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G4D MBOAT7 PLA2G2E PLA2G4E PLAAT3 PLA2G4C PLBD1 PLA2G4A PLA2G10 PLA2G2A PLA2R1 PLA2G1B PLA2G5 GENE SILENCING BY RNA%REACTOME%R-HSA-211000.3 Gene Silencing by RNA NUP42 NUP43 RAE1 RANBP2 RAN NUP35 PIWIL2 NUP37 TDRKH PIWIL1 PIWIL4 PLD6 HENMT1 ASZ1 MAEL MOV10L1 MYBL1 TDRD9 TDRD6 TDRD1 ANG TDRD12 FKBP6 HSP90AA1 DDX4 NUP214 TNRC6C TNRC6A TNRC6B TSNAX AGO3 PRKRA AGO4 POLR2A AGO1 POLR2B AGO2 POLR2C DICER1 POLR2D TSN POLR2E POLR2F TARBP2 POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 POLR2K H2AC19 POLR2L H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 IPO8 H2AC7 SEC13 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 NUP107 NUP188 H2BC11 DGCR8 H3C15 NUP210 NUP93 H2BS1 POM121 NUP205 H2AZ1 H2BC9 H2AZ2 AAAS H4C9 H2BC8 NUP160 H2BC5 POM121C NUP85 H2BC3 TPR NUP88 H2BC1 NUP155 NUP153 H2AC20 BCDIN3D XPO5 ELAC2 DROSHA NUP62 NDC1 NUP133 NUP50 NUP54 CYTOPROTECTION BY HMOX1%REACTOME%R-HSA-9707564.1 Cytoprotection by HMOX1 CREBBP HDAC3 KEAP1 CSNK2A1 CSNK2A2 CSNK2B HMOX2 NFE2L2 BLVRB BLVRA HM13 SKP1 ABCC1 UBA52 MAFK NLRP3 STAT3 CUL1 PRKCD UBB HBB UBC RPS27A SIN3A NCOR2 NCOR1 MT-CO1 FABP1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 SURF1 COX7B COX7C COX8A RXRA RBX1 COX5B PPARA COX5A COX6C LRPPRC SKP2 TACO1 COX6A1 COX6B1 COX19 COX16 COX18 FBXL17 BACH1 COX11 COX14 PSMD8 PSMD9 CYCS PSMD6 PSMD7 PSMD4 COX20 COX4I1 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 CUL3 STAP2 PSME1 PSME2 PSMD10 PSMB11 PSMD12 NDUFA4 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 NCOA1 PSMB3 MED1 PSMB1 PSMF1 ALB NCOA2 PSMB8 SMARCD3 PSMB9 SEM1 CHD9 NCOA6 PSMC5 HELZ2 PSMC6 TBL1XR1 PSMC3 TGS1 PSMC4 CARM1 PSMC1 TBL1X PSMC2 PTK6 TXNIP HBA2 HMOX1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 76%193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol NCOA1 HSD3B7 ACOT8 NCOA2 PTGIS AKR1C1 RXRA AKR1C3 NR1H4 AKR1C2 AKR1C4 BAAT CYP7B1 CYP8B1 CYP27A1 AMACR ACOX2 AKR1D1 HSD17B4 SLC27A2 SLC27A5 ABCB11 CYP7A1 RHOBTB3 ATPASE CYCLE%REACTOME%R-HSA-9706019.2 RHOBTB3 ATPase cycle CUL3 LRRC41 CCNE1 RAB9A VHL HGS RAB9B RHOBTB3 PLIN3 INSERTION OF TAIL-ANCHORED PROTEINS INTO THE ENDOPLASMIC RETICULUM MEMBRANE%REACTOME DATABASE ID RELEASE 76%9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane PRNP UBL4A EMD STX1A SERP1 SGTA VAMP2 GET1 GET3 GET4 APP CAMLG SEC61G SEC61B BAG6 VAPA OTOF HMOX1 STX5 PI METABOLISM%REACTOME DATABASE ID RELEASE 76%1483255 PI Metabolism RAB4A PIK3CA SYNJ2 SYNJ1 PIP5K1C PIP4P1 INPPL1 PIK3C2A RAB5A ARF3 MTMR4 PIK3R6 PIK3CG PIK3R5 ARF1 PITPNB OCRL PI4K2B RUFY1 PIK3R1 MTMR2 SACM1L MTMR8 PI4KA MTMR9 MTMR6 MTMR7 PIK3R2 INPP5J INPP5K PTEN TNFAIP8L1 TNFAIP8L3 TNFAIP8L2 PLEKHA1 PLEKHA2 VAC14 PLEKHA5 MTMR10 PLEKHA6 MTMR12 PLEKHA3 MTM1 PLEKHA4 RAB14 INPP4A PLEKHA8 FIG4 INPP4B PIKFYVE TPTE2 INPP5F PI4K2A PIP5K1A PIP5K1B INPP5D SBF1 SBF2 PI4KB TNFAIP8 PIK3C2G PIK3R4 PIK3C2B PTPN13 PIK3CB TPTE MTMR3 PIK3CD MTMR14 INPP5E PIK3R3 BMX PIP4K2A PIP4K2B PNPLA7 GDE1 GDPD1 PIP4K2C GDPD3 PIK3C3 PNPLA6 ENPP6 GDPD5 MTMR1 PORPHYRIN METABOLISM%REACTOME DATABASE ID RELEASE 76%189445 Porphyrin metabolism ALAS1 GSTA1 PPOX HMBS UGT1A4 CPOX FECH ABCG2 HMOX2 ALB ALAD BLVRB BLVRA ABCC2 UGT1A1 FABP1 UROD UROS ALAS2 SLCO1B1 COX15 ABCC1 COX10 SLCO1B3 HMOX1 TBC RABGAPS%REACTOME%R-HSA-8854214.1 TBC RABGAPs RAB6B TBC1D15 TBC1D16 GABARAPL2 RAB4A SYTL1 RAB11A RAB11B GABARAP ARF6 OPTN GGA2 GGA1 GGA3 TSC2 TSC1 TBC1D2 RABEP1 TBC1D10C TBC1D3 RAB5A MAP1LC3B TBC1D10A TBC1D20 TBC1D24 TBC1D10B RAB7A TBC1D7 RAB8B RAB33A RAB33B RAB35 RAB7B RAB5B RAB5C RAB8A RABGAP1 RABGEF1 TBC1D13 ULK1 TBC1D14 RAB6A TBC1D17 INTRINSIC PATHWAY OF FIBRIN CLOT FORMATION%REACTOME DATABASE ID RELEASE 76%140837 Intrinsic Pathway of Fibrin Clot Formation SERPINA5 C1QBP F2 SERPIND1 A2M F10 F8 VWF GP1BB KNG1 KLKB1 F12 F11 GP1BA GP5 GP9 PROC F9 SERPING1 SERPINE2 SERPINC1 PROS1 PRCP NR1D1 (REV-ERBA) REPRESSES GENE EXPRESSION%REACTOME%R-HSA-1368071.3 NR1D1 (REV-ERBA) represses gene expression NCOR1 HDAC3 NR1D1 DNA DAMAGE BYPASS%REACTOME DATABASE ID RELEASE 76%73893 DNA Damage Bypass POLD2 REV3L RCHY1 USP1 UBE2B POLE4 DTL PCLAF RAD18 USP43 POLE2 POLE3 VCP PCNA RBX1 UBA52 WDR48 USP10 UFD1 UBB RFC5 UBC RFC3 UBA7 POLK RFC4 POLI RFC2 TRIM25 RPS27A POLE UBE2L6 RFC1 DDB1 NPLOC4 SPRTN ISG15 RPA1 CUL4A RPA2 RPA3 POLD3 CUL4B POLH POLD4 REV1 POLD1 MAD2L2 INTERACTIONS OF REV WITH HOST CELLULAR PROTEINS%REACTOME DATABASE ID RELEASE 76%177243 Interactions of Rev with host cellular proteins NUP42 NUP210 NUP43 rev RAE1 RANBP2 NUP93 POM121 RAN NUP205 NUP35 NUP37 AAAS NUP160 POM121C NUP85 NPM1 TPR NUP88 XPO1 NUP155 RANGAP1 NUP214 NUP153 KPNB1 RCC1 SEC13 NUP62 NDC1 NUP133 RANBP1 NUP107 NUP188 NUP50 NUP54 BASE-EXCISION REPAIR, AP SITE FORMATION%REACTOME DATABASE ID RELEASE 76%73929 Base-Excision Repair, AP Site Formation H2BS1 H2AZ1 H2BC9 H2AZ2 H4C9 H2BC8 MPG H2BC5 H2BC3 H2BC1 H2AX H2AB1 H2AC20 H2AC19 H2AC14 H2BC21 OGG1 H2BU1 NTHL1 TDG MBD4 H2AC8 ACD H2AC6 TINF2 H2AC7 TERF1 TERF2 H2BC17 SMUG1 H2BC12 NEIL3 H2BC13 NEIL2 H3-4 H2BC14 POT1 H2AJ TERF2IP NEIL1 H2BC15 H2BC11 CELLULAR HEXOSE TRANSPORT%REACTOME%R-HSA-189200.4 Cellular hexose transport SLC2A9 MFSD4B SLC45A3 SLC2A1 SLC2A2 SLC5A9 SLC5A1 SLC2A3 SLC2A4 SLC5A2 SLC50A1 SLC2A6 SLC2A10 SLC2A7 SLC2A8 SLC5A10 FGF21 SLC2A14 SLC2A11 SLC2A12 SLC5A4 DISEASES OF DNA DOUBLE-STRAND BREAK REPAIR%REACTOME DATABASE ID RELEASE 76%9675136 Diseases of DNA Double-Strand Break Repair BRCA1 BARD1 NGF PROCESSING%REACTOME DATABASE ID RELEASE 76%167060 NGF processing NGF PCSK6 PCSK5 FURIN CD28 CO-STIMULATION%REACTOME%R-HSA-389356.3 CD28 co-stimulation MAPKAP1 PIK3CA GRAP2 LCK MAP3K14 CD28 FYN PRR5 PAK3 AKT2 MLST8 VAV1 AKT1 LYN MAP3K8 YES1 MTOR PAK2 PDPK1 CD86 CD80 THEM4 RICTOR RAC1 PIK3R1 PIK3R3 CDC42 PAK1 TRIB3 PIK3R2 AKT3 DEFECTIVE CYP2U1 CAUSES SPG56%REACTOME DATABASE ID RELEASE 76%5579011 Defective CYP2U1 causes SPG56 CYP2U1 INTEGRIN SIGNALING%REACTOME DATABASE ID RELEASE 76%354192 Integrin signaling FN1 FGB SHC1 FGA CRK VWF SOS1 FGG TLN1 ITGA2B PTPN1 SYK APBB1IP BCAR1 AKT1 PTK2 CSK PDPK1 RASGRP2 RASGRP1 ITGB3 RAP1B RAP1A RAPGEF3 RAPGEF4 SRC TRANSPORT AND SYNTHESIS OF PAPS%REACTOME DATABASE ID RELEASE 76%174362 Transport and synthesis of PAPS SLC35B3 SLC26A2 SLC35B2 SLC26A1 PAPSS2 PAPSS1 PTK6 REGULATES RHO GTPASES, RAS GTPASE AND MAP KINASES%REACTOME%R-HSA-8849471.2 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases HRAS ELMO1 DOCK1 RASA1 CRK PXN NRAS PTK6 RAC1 BCAR1 RHOA ELMO2 ARHGAP35 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646304.2 Evasion of Oxidative Stress Induced Senescence Due to p14ARF Defects CDKN2A NEF MEDIATED DOWNREGULATION OF CD28 CELL SURFACE EXPRESSION%REACTOME%R-HSA-164939.1 Nef mediated downregulation of CD28 cell surface expression CD28 AP2M1 nef RUNX2 REGULATES OSTEOBLAST DIFFERENTIATION%REACTOME%R-HSA-8940973.1 RUNX2 regulates osteoblast differentiation HDAC3 RB1 CBFB GLI3 HDAC6 HES1 WWTR1 ABL1 AR HEY1 HEY2 MAF ZNF521 SATB2 MAPK1 UCMA COL1A1 YAP1 BGLAP MAPK3 SRC SP7 YES1 CYTOCHROME P450 - ARRANGED BY SUBSTRATE TYPE%REACTOME DATABASE ID RELEASE 76%211897 Cytochrome P450 - arranged by substrate type CYP3A7 CYP51A1 RXRA CYP2B6 CYP4B1 CYP4F2 CYP4F3 CYP4F8 CYP46A1 CYP2S1 CYP1A1 CYP7A1 PTGIS CYP21A2 AHRR CYP26A1 CYP27B1 CYP11B1 CYP26B1 NR1H4 CYP2A13 CYP24A1 CYP26C1 CYP2F1 CYP2R1 CYP7B1 CYP2C9 ARNT2 CYP8B1 CYP2C8 CYP2D6 CYP27A1 CYP39A1 CYP1A2 CYP2E1 CYP3A4 CYP2W1 AHR CYP4F22 CYP2C19 CYP2C18 CYP19A1 POMC CYP11A1 CYP2J2 CYP4F11 CYP4F12 NCOA1 NCOA2 CYP11B2 TBXAS1 CYP4A22 CYP4V2 FDXR CYP4A11 CYP1B1 CYP3A43 ARNT CYP2A7 CYP2A6 POR CYP2U1 FDX1 FDX2 CYP3A5 INSULIN PROCESSING%REACTOME DATABASE ID RELEASE 76%264876 Insulin processing EXOC4 EXOC3 EXOC6 SLC30A7 EXOC5 PCSK1 SLC30A6 SLC30A8 EXOC2 VAMP2 SLC30A5 EXOC1 MYO5A RAB27A ERO1A KIF5C KIF5B KIF5A STX1A PCSK2 ERO1B MYRIP CLTRN CPE EXOC8 EXOC7 INS FORMATION OF THE HIV-1 EARLY ELONGATION COMPLEX%REACTOME%R-HSA-167158.2 Formation of the HIV-1 Early Elongation Complex CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RESOLUTION OF D-LOOP STRUCTURES%REACTOME DATABASE ID RELEASE 76%5693537 Resolution of D-Loop Structures BLM BRIP1 ATM BARD1 BRCA1 EXO1 RTEL1 RMI2 MUS81 SLX4 EME1 RMI1 EME2 BRCA2 GEN1 TOP3A RAD51AP1 SLX1B XRCC2 SPIDR WRN XRCC3 PALB2 RBBP8 RAD51D MRE11 RAD51 KAT5 NBN RAD50 RAD51B RAD51C DNA2 TRANSLATION OF REPLICASE AND ASSEMBLY OF THE REPLICATION TRANSCRIPTION COMPLEX%REACTOME%R-HSA-9679504.2 Translation of Replicase and Assembly of the Replication Transcription Complex 8b PIK3R4 9b UVRAG MAP1LC3B CHMP4C CHMP4B CHMP3 CHMP4A CHMP2B CHMP2A CHMP6 CHMP7 BECN1 1a PIK3C3 rep BIOSYNTHESIS OF DPAN-6 SPMS%REACTOME%R-HSA-9025106.1 Biosynthesis of DPAn-6 SPMs ALOX15 ALOX12 DEFECTIVE ABCD4 CAUSES MAHCJ%REACTOME%R-HSA-5683329.2 Defective ABCD4 causes MAHCJ ABCD4 CHAPERONE MEDIATED AUTOPHAGY%REACTOME DATABASE ID RELEASE 76%9613829 Chaperone Mediated Autophagy UBB HDAC6 HSP90AA1 HBB PARK7 CFTR UBC HSPA8 RPS27A PCNT PLIN3 RNASE1 PLIN2 GFAP EEF1A1 CETN1 IFT88 ARL13B LAMP2 UBA52 HSP90AB1 DAP12 SIGNALING%REACTOME%R-HSA-2424491.2 DAP12 signaling KLRK1 PIK3CA PLCG1 SOS1 B2M GRAP2 LCK SYK FYN KLRC2 VAV3 BTK KLRD1 HLA-E HRAS PIK3CB LCP2 NRAS TREM2 RAC1 PIK3R1 VAV2 TYROBP PIK3R2 PLCG2 CYP2E1 REACTIONS%REACTOME DATABASE ID RELEASE 76%211999 CYP2E1 reactions CYP2F1 CYP2C9 CYP2C8 CYP2D6 CYP2C19 CYP2E1 CYP2A7 CYP2A6 CYP2B6 CYP2S1 CYP2A13 STIMULATION OF THE CELL DEATH RESPONSE BY PAK-2P34%REACTOME DATABASE ID RELEASE 76%211736 Stimulation of the cell death response by PAK-2p34 PAK2 CASP3 EARLY PHASE OF HIV LIFE CYCLE%REACTOME%R-HSA-162594.2 Early Phase of HIV Life Cycle CXCR4 CD4 BANF1 rev gag-pol vif LIG1 PPIA nef vpr PSIP1 vpu gag XRCC4 CCR5 XRCC6 XRCC5 LIG4 HMGA1 env FEN1 KPNA1 SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 27-HYDROXYCHOLESTEROL%REACTOME DATABASE ID RELEASE 76%193807 Synthesis of bile acids and bile salts via 27-hydroxycholesterol NCOA1 HSD3B7 NCOA2 PTGIS AKR1C1 RXRA AKR1C3 NR1H4 AKR1C2 AKR1C4 CYP7B1 CYP8B1 CYP27A1 AKR1D1 CYP7A1 INACTIVATION, RECOVERY AND REGULATION OF THE PHOTOTRANSDUCTION CASCADE%REACTOME%R-HSA-2514859.2 Inactivation, recovery and regulation of the phototransduction cascade METAP2 PDE6B PDE6A NMT2 PDE6G RGS9BP GNAT1 CNGA1 SAG GRK1 GUCA1B FNTB GUCA1A GRK7 PRKCA GUCY2D GUCA1C GUCY2F GNB1 RHO CNGB1 NMT1 GNGT1 FNTA PRKCQ RCVRN CALM1 CAMKMT PPEF1 METAP1 REGULATION OF EXPRESSION OF SLITS AND ROBOS%REACTOME DATABASE ID RELEASE 76%9010553 Regulation of expression of SLITs and ROBOs COL4A5 RPL4 RPL5 RPL30 RPL3 HOXA2 RPL32 RPL31 RPL34 RPLP1 RPL10L ISL1 RPLP0 RPL10A RPL8 RPL6 CUL2 RPL7 UPF3A RPS4X RPS15 USP33 RPL7A RPS14 RPS17 UPF2 RPS16 RPL18A RPS19 ZSWIM8 RPS18 RPL36AL RPL36 RPL35 MSI1 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 NCBP1 RPS8 NCBP2 RPS5 UBB RPL23 RPL22 RPS6 UBC RPL13A RPSA LHX3 PABPC1 RPS3A RPL9P9 LHX2 RPS27A RPL37A RPL24 RPL27 LHX4 LHX9 ETF1 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 GSPT2 GSPT1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 DAG1 RPL35A RPL23A RPL3L RPS26 ELOB RPS25 ELOC RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU EIF4A3 RBX1 RPS21 CASC3 RPL26L1 RPS24 MAGOH RPS23 ROBO2 ROBO1 RBM8A UPF3B MAGOHB RNPS1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 LDB1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 SLIT1 PSMA7 PSMB10 PSMA8 PSMB6 SLIT2 PSMB7 PSMB4 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 NONHOMOLOGOUS END-JOINING (NHEJ)%REACTOME DATABASE ID RELEASE 76%5693571 Nonhomologous End-Joining (NHEJ) TDP2 TDP1 DCLRE1C RIF1 ATM SUMO1 BRCC3 BARD1 POLL POLM BABAM1 BABAM2 BRCA1 UIMC1 H2AX RNF8 NSD2 H2BC21 H2BU1 H2BC17 H2BC12 H2BC13 H3-4 H2BC14 H2BC15 RAD50 H2BC11 HERC2 PAXIP1 H2BS1 PRKDC TP53BP1 H2BC9 XRCC4 XRCC6 H4C9 H2BC8 XRCC5 H2BC5 H2BC3 H2BC1 RNF168 ABRAXAS1 MRE11 MDC1 KAT5 UBE2V2 NBN LIG4 PIAS4 UBE2N NHEJ1 CAP-DEPENDENT TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 76%72737 Cap-dependent Translation Initiation EIF2S2 EIF2S1 EIF2S3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A EIF5 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF5B EIF4H EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 EIF4A1 EIF4EBP1 EIF4E EIF4B ORGANELLE BIOGENESIS AND MAINTENANCE%REACTOME DATABASE ID RELEASE 76%1852241 Organelle biogenesis and maintenance CREBBP CHCHD3 ATP5MC1 MEF2C HSP90AA1 CEP57 YWHAE CETN2 KIFAP3 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL SSTR3 CEP250 NEK2 PRKACA NINL CEP290 RAB8A YWHAG CDK5RAP2 TFB1M OFD1 CEP135 TUBB KIF3B CEP131 HDAC6 HAUS4 KIF3C HAUS3 CSNK1D ATP5F1A HAUS6 ATP5F1B HAUS5 CSNK1E TUBG1 DYNLL1 CKAP5 HAUS2 MTX2 TUBA4A HAUS1 AKAP9 CEP63 MAPRE1 TTC26 DYNC2I1 SFI1 TRAF3IP1 DYNLT2B HSPB11 DYNC2LI1 SDCCAG8 PAFAH1B1 IFT74 DYNC1I2 DYNLT5 DYNLT2 DCTN2 IFT80 SSNA1 IFT20 DCTN3 IFT22 IFT43 TTC30B PKD2 IFT81 PKD1 TTC30A CNGA2 HAUS8 BBS9 IFT27 DYNLRB2 CNGA4 HAUS7 PRKAR2B BBS7 DYNLRB1 CEP70 BBS5 IFT46 BBS4 CLUAP1 CEP72 MKKS CEP192 CYS1 LZTFL1 BBS10 PCNT CEP76 RP2 BBS12 CLASP1 CEP78 CNGB1 UNC119B PLK4 DYNC1H1 ARL6 ARL3 ODF2 ASAP1 CEP152 NDE1 ARL13B INPP5E PLK1 TUBB4B PDE6D TUBB4A NPHP3 RAB11FIP3 NEDD1 BBS2 CENPJ BBS1 ALMS1 BBIP1 CDK1 TTC8 CEP41 ATF2 CEP43 CRTC2 CRTC3 CRTC1 RXRA MEF2D PPARGC1A NR1D1 PPARA KIF17 SIRT3 ESRRA ALAS1 MICOS13 MICOS10 MT-ATP6 CHCHD6 MTERF1 GABPA TWNK SIRT4 GBF1 SIRT5 RAB11A PPRC1 POLG2 PERM1 ATP5MC2 ATP5MC3 TFAM NRF1 APOO TFB2M POLRMT ATP5MG TRIP11 ATP5MF ATP5ME DMAC2L ATP5PF ATP5PD APOOL ATP5PB IDH2 DNAJC11 IMMT ATP5F1C ATP5F1D ATP5F1E MT-ATP8 TMEM11 MAPK12 ATP5PO NCOA1 SSBP1 MED1 NCOA2 SMARCD3 CHD9 NCOA6 HELZ2 TBL1XR1 TGS1 CARM1 TBL1X HDAC3 HCFC1 PRKAB2 PPARGC1B PRKAA2 PRKAG1 PRKAG2 PRKAB1 PRKAG3 CCT3 CALM1 CEP97 TCP1 DYNLL2 CCT8 CCT5 CCT4 TNPO1 NPHP4 SOD2 C2CD3 TCTN3 TCTN2 TCTN1 CC2D2A IQCB1 KIF24 CREB1 TMEM216 FBF1 NCOR1 TTBK2 CAMK4 TMEM67 GLUD1 NPHP1 MARK4 SEPTIN2 MAPK14 SCLT1 MAPK11 GLUD2 AHI1 CEP83 CEP162 B9D1 CEP89 ACSS2 IFT172 B9D2 DYNC2H1 RPGRIP1L IFT88 ATAT1 HSPA9 SMO KIF3A TTC21B IFT122 RAB3IP MKS1 IFT52 IFT57 IFT140 WDR35 RHO ARF4 WDR19 EXOC8 EXOC7 CYCS EXOC4 EXOC3 EXOC6 EXOC5 CCT2 EXOC2 EXOC1 MCHR1 SAMM50 MTX1 ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS%REACTOME DATABASE ID RELEASE 76%2122948 Activated NOTCH1 Transmits Signal to the Nucleus PSEN1 PSENEN JAG2 NEURL1 NCSTN CNTN1 JAG1 UBA52 NEURL1B DTX4 MIB2 MIB1 ARRB1 UBB ARRB2 UBC RPS27A NUMB PSEN2 APH1A APH1B ADAM10 DNER ITCH ADAM17 DTX1 DTX2 DLL1 NOTCH1 DLK1 DLL4 TIE2 SIGNALING%REACTOME DATABASE ID RELEASE 76%210993 Tie2 Signaling ANGPT4 HRAS ANGPT2 SHC1 PIK3CB PIK3CA SOS1 NRAS PTPN11 PIK3R1 GRB14 GRB7 DOK2 ANGPT1 TEK PIK3R2 TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE%REACTOME%R-HSA-202430.5 Translocation of ZAP-70 to Immunological synapse TRAC CD3E TRBC1 LCK TRBV12-3 TRAV29DV5 TRBV7-9 TRAV19 TRAV8-4 HLA-DQA2 HLA-DQA1 HLA-DRB5 CD4 HLA-DRB4 HLA-DRB3 HLA-DRB1 CD3G CD3D PTPN22 HLA-DPA1 HLA-DQB2 HLA-DQB1 HLA-DPB1 ZAP70 HLA-DRA GLYCOSPHINGOLIPID METABOLISM%REACTOME DATABASE ID RELEASE 76%1660662 Glycosphingolipid metabolism ARSA ASAH1 GBA SUMF2 SUMF1 CPTP ARSB ASAH2 UGCG UGT8 ARSL GLB1L ARSJ ARSK ARSH ESYT1 ARSI B4GALNT1 ARSF ARSG ARSD NEU2 B3GALNT1 NEU3 GM2A GALC NEU1 GLA ESYT3 ESYT2 CTSA GLTP PSAP CERK GBA3 GBA2 HEXB SMPD4 HEXA STS SMPD3 SMPD1 SMPD2 ENPP7 GLB1 NETRIN-1 SIGNALING%REACTOME%R-HSA-373752.2 Netrin-1 signaling MYO10 DOCK1 TRPC7 TRPC6 PLCG1 TRPC5 TRPC3 TRPC4 TRPC1 SIAH2 TRIO EZR SIAH1 ROBO1 RGMB RGMA PTPN11 WASL DSCAM CDC42 PAK1 MAPK8 UNC5A DCC UNC5B PITPNA UNC5C NCK1 UNC5D NTN1 AGAP2 DSCAML1 HJV SLIT1 SLIT3 SLIT2 MAPK12 MAPK13 PTK2 RAC1 NEO1 MAPK14 MAPK11 PRKCQ NTN4 ABLIM1 SRC ABLIM2 ABLIM3 RNA POLYMERASE II PRE-TRANSCRIPTION EVENTS%REACTOME DATABASE ID RELEASE 76%674695 RNA Polymerase II Pre-transcription Events CTDP1 RTF1 ELL MLLT3 CCNT1 SUPT6H SUPT4H1 IWS1 ELOA3DP LEO1 ELOA EAF1 NELFB EAF2 ELOB PAF1 ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H GTF2A1 ELOA3P GTF2A2 GTF2B ELOA2 TAF9 SSRP1 TAF1L CDK9 CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 CCNT2 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 NCBP1 NCBP2 CCNK TCEA1 AFF4 CDC73 CTR9 WDR61 MLLT1 DEFECTIVE TCN2 CAUSES HEREDITARY MEGALOBLASTIC ANEMIA%REACTOME%R-HSA-3359454.1 Defective TCN2 causes hereditary megaloblastic anemia TCN2 ACTIVATION OF G PROTEIN GATED POTASSIUM CHANNELS%REACTOME DATABASE ID RELEASE 76%1296041 Activation of G protein gated Potassium channels KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 GABBR2 GABBR1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 VEGFR2 MEDIATED CELL PROLIFERATION%REACTOME DATABASE ID RELEASE 76%5218921 VEGFR2 mediated cell proliferation PRKCD PRKCA PRKCB HRAS KDR RASA1 PDPK1 PLCG1 NRAS PRKCZ SPHK1 CALM1 AHCYL1 ITPR1 ITPR2 ITPR3 CLEARANCE OF SERATONIN%REACTOME%R-HSA-380615.4 Clearance of seratonin SLC6A4 MAOA ALDH2 SARS-COV-2 GENOME REPLICATION AND TRANSCRIPTION%REACTOME%R-HSA-9694682.1 SARS-CoV-2 Genome Replication and Transcription GSK3B RB1 ZCRB1 DDX5 VHL N GSK3A rep GASTRIN-CREB SIGNALLING PATHWAY VIA PKC AND MAPK%REACTOME DATABASE ID RELEASE 76%881907 Gastrin-CREB signalling pathway via PKC and MAPK PRKCA MAPK7 HRAS MMP3 CCKBR SOS1 NRAS CREB1 GAST HBEGF MAPK1 EGFR RPS6KA3 RPS6KA2 RPS6KA1 MAPK3 PHOSPHOLIPASE C-MEDIATED CASCADE; FGFR3%REACTOME DATABASE ID RELEASE 76%5654227 Phospholipase C-mediated cascade; FGFR3 FGF23 FGF16 FGF1 FGF18 FGF2 PLCG1 FGF4 FGF9 FGF20 ABO BLOOD GROUP BIOSYNTHESIS%REACTOME DATABASE ID RELEASE 76%9033807 ABO blood group biosynthesis FUT2 ABO FUT1 SYNDECAN INTERACTIONS%REACTOME DATABASE ID RELEASE 76%3000170 Syndecan interactions PRKCA ACTN1 ITGB4 FGF2 TRAPPC4 ITGB3 SDC1 ITGB1 VTN ITGAV ITGA6 TGFB1 ITGA2 SDC4 SDC2 CASK THBS1 SDC3 ITGB5 TNC EVASION OF ONCOGENE INDUCED SENESCENCE DUE TO P14ARF DEFECTS%REACTOME%R-HSA-9646303.2 Evasion of Oncogene Induced Senescence Due to p14ARF Defects CDKN2A DISORDERS OF DEVELOPMENTAL BIOLOGY%REACTOME%R-HSA-9675151.2 Disorders of Developmental Biology NCOR1 HDAC3 CAMK4 HDAC1 PRKACA GPS2 CALM1 TBL1XR1 NCOR2 SIN3A TBL1X INTERLEUKIN-10 SIGNALING%REACTOME DATABASE ID RELEASE 76%6783783 Interleukin-10 signaling CSF2 TNFRSF1B CCL5 TNFRSF1A CCL4 CXCL10 CCL3 CCL2 IL12B IL10 TYK2 FCER2 CXCL8 ICAM1 CCR1 IL18 CXCL1 STAT3 IL10RA IL1A IL1B TNF PTAFR CXCL2 TIMP1 IL6 PTGS2 CCL3L3 LIF IL10RB IL12A CCL19 CD86 CD80 CCR5 IL1RN CCL22 CCR2 IL1R2 CCL20 IL1R1 FPR1 JAK1 CSF1 CSF3 INTERLEUKIN-15 SIGNALING%REACTOME DATABASE ID RELEASE 76%8983432 Interleukin-15 signaling STAT5A STAT5B IL2RG SHC1 IL2RB GRB2 SOS1 SOS2 GAB2 JAK3 IL15RA STAT3 IL15 JAK1 CELL DEATH SIGNALLING VIA NRAGE, NRIF AND NADE%REACTOME DATABASE ID RELEASE 76%204998 Cell death signalling via NRAGE, NRIF and NADE PSEN1 BCL2L11 NGF NCSTN SOS1 GNA13 TRIO RASGRF2 MCF2L VAV3 ARHGEF16 CASP3 VAV1 ARHGEF40 ARHGEF5 ARHGEF26 PREX1 TIAM2 KALRN OBSCN SQSTM1 NGEF YWHAE BEX3 MAGED1 PSEN2 APH1A APH1B ECT2 VAV2 ARHGEF33 TIAM1 ARHGEF35 ARHGEF37 ARHGEF39 ARHGEF38 NET1 ARHGEF10L MAPK8 AATF AKAP13 CASP2 PSENEN ABR ARHGEF11 ARHGEF10 PLEKHG2 ARHGEF12 ARHGEF15 ARHGEF17 ARHGEF19 ARHGEF9 ARHGEF7 ARHGEF3 ARHGEF4 ARHGEF1 ARHGEF2 SOS2 UBA52 ITGB3BP MCF2 ARHGEF6 FGD1 FGD2 FGD3 FGD4 BAD UBB PLEKHG5 UBC RPS27A RAC1 ARHGEF18 ITSN1 TRAF6 NGFR SIGNALING BY FLT3 ITD AND TKD MUTANTS%REACTOME%R-HSA-9703648.1 Signaling by FLT3 ITD and TKD mutants PIM1 STAT5A STAT5B HRAS NOX4 BCL2L1 GRB2 PIK3CA FLT3 SOS1 NRAS PTPN11 PIK3R1 GAB2 CDKN1A RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER%REACTOME DATABASE ID RELEASE 76%76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter POU2F1 CRCP ZNF143 SNAPC5 SNAPC1 SNAPC2 SNAPC3 SNAPC4 POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP BRF2 BDP1 POLR1C POLR1D PREVENTION OF PHAGOSOMAL-LYSOSOMAL FUSION%REACTOME DATABASE ID RELEASE 76%9636383 Prevention of phagosomal-lysosomal fusion secA2 UBB VPS33B lprG UBC HGS RPS27A RAB5A RAB7A CORO1A lpdC esxH esxG UBA52 Rv1410c sapM ndkA ptpA DEFECTIVE SLC40A1 CAUSES HEMOCHROMATOSIS 4 (HFE4) (MACROPHAGES)%REACTOME DATABASE ID RELEASE 76%5619049 Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages) CP SLC40A1 ENZYMATIC DEGRADATION OF DOPAMINE BY COMT%REACTOME%R-HSA-379397.4 Enzymatic degradation of dopamine by COMT LRTOMT MAOA COMT ERYTHROCYTES TAKE UP CARBON DIOXIDE AND RELEASE OXYGEN%REACTOME%R-HSA-1237044.3 Erythrocytes take up carbon dioxide and release oxygen CYB5R2 RHAG CYB5R1 CYB5R4 HBB CYB5RL HBA2 CA1 CA2 CA4 SLC4A1 AQP1 RET SIGNALING%REACTOME%R-HSA-8853659.4 RET signaling PSPN SHC1 RET GAB1 PIK3CA PLCG1 GDNF SOS1 PRKACG PRKACB GRB7 SHANK3 ARTN SHC3 PDLIM7 MAPK7 PRKCA GFRA1 GFRA3 IRS2 PIK3CB GFRA2 GFRA4 RAP1GAP PTPN11 PIK3CD DOK1 PIK3R1 NRTN PIK3R3 DOK2 PRKACA FRS2 GRB10 GAB2 DOK4 DOK5 DOK6 PIK3R2 DEFECTIVE F9 VARIANT DOES NOT ACTIVATE FX%REACTOME%R-HSA-9673202.1 Defective F9 variant does not activate FX F9 F8 F10 LDL CLEARANCE%REACTOME DATABASE ID RELEASE 76%8964038 LDL clearance AP2B1 LSR NCEH1 SOAT1 NPC1 SOAT2 NPC2 APOB CES3 PCSK9 CLTA CLTC AP2A1 AP2A2 LIPA AP2S1 LDLR LDLRAP1 AP2M1 TRIF(TICAM1)-MEDIATED TLR4 SIGNALING%REACTOME DATABASE ID RELEASE 76%937061 TRIF(TICAM1)-mediated TLR4 signaling TAB1 UBE2V1 PPP2R1B MAP2K6 CASP8 FOS RIPK1 PPP2R5D FADD HMGB1 APP MEF2A MEF2C ELK1 MAPK1 RPS6KA3 RPS6KA5 RPS6KA2 RPS6KA1 MAPK3 TANK PPP2CA PPP2CB UBE2D2 UBE2D3 TBK1 PTPN11 PPP2R1A IKBKE UBE2D1 BTRC IRF3 RIPK3 TRAF3 NFKB1 NKIRAS1 NKIRAS2 SKP1 MAPK8 NFKBIB FBXW11 SAA1 TICAM2 LY96 TICAM1 CD14 TLR4 IRF7 BIRC2 UBA52 MAP2K1 BIRC3 CUL1 DUSP4 ATF1 DUSP3 MAP3K8 VRK3 MAP2K3 DUSP6 MAP2K4 DUSP7 UBB IKBKB MAPK7 MAPKAPK3 MAP2K7 CHUK MAPKAPK2 UBC JUN TNIP2 NFKBIA RELA RPS27A IKBKG MAPK9 NFKB2 MAPK10 CREB1 NOD1 NOD2 MAPK14 AGER MAPK11 IRAK1 IRAK2 S100A12 ATF2 RIPK2 S100B TRAF6 UBE2N TAB3 MAP3K7 TAB2 THE CANONICAL RETINOID CYCLE IN RODS (TWILIGHT VISION)%REACTOME%R-HSA-2453902.4 The canonical retinoid cycle in rods (twilight vision) TTR HSD17B6 RDH11 ABCA4 RDH8 LRAT RHO RBP4 NAPEPLD CYP4V2 STRA6 RBP1 DHRS9 RDH10 RLBP1 RDH16 MYO7A RDH5 RBP3 RDH12 RPE65 HSD17B1 SDR9C7 TRANSCRIPTION OF THE HIV GENOME%REACTOME DATABASE ID RELEASE 76%167172 Transcription of the HIV genome CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H GTF2A1 ELOA3P tat GTF2A2 GTF2B ELOA2 TAF9 SSRP1 TAF1L CDK9 CCNH GTF2E1 RNMT GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 CCNT2 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 RNGTT TAF3 GTF2H1 TAF2 GTF2H2 TAF1 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 NCBP1 NCBP2 CCNK TCEA1 POLYMERASE SWITCHING%REACTOME%R-HSA-69091.2 Polymerase switching POLD2 RFC5 RFC3 RFC4 RFC2 PRIM2 PRIM1 RFC1 POLA1 POLA2 PCNA POLD3 POLD4 POLD1 FORMATION OF THE EARLY ELONGATION COMPLEX%REACTOME%R-HSA-113418.3 Formation of the Early Elongation Complex CTDP1 SUPT4H1 NELFB NELFCD NELFA NELFE CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J NCBP1 POLR2K POLR2L NCBP2 GTF2H1 GTF2H2 SUPT5H GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 RUNX1 REGULATES ESTROGEN RECEPTOR MEDIATED TRANSCRIPTION%REACTOME%R-HSA-8931987.1 RUNX1 regulates estrogen receptor mediated transcription KCTD6 CBFB AXIN1 RUNX1 ESR1 GPAM RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES%REACTOME DATABASE ID RELEASE 76%380320 Recruitment of NuMA to mitotic centrosomes HSP90AA1 CEP57 YWHAE CETN2 CEP164 CCP110 PCM1 ACTR1A TUBA1A PPP2R1A CNTRL CEP250 NEK2 PRKACA NINL CEP290 YWHAG CDK5RAP2 OFD1 CEP135 TUBB CEP131 HAUS4 TUBGCP2 HAUS3 CSNK1D HAUS6 HAUS5 TUBGCP5 CSNK1E TUBGCP6 TUBG1 TUBGCP3 DYNLL1 TUBGCP4 CKAP5 HAUS2 TUBA4A HAUS1 AKAP9 TUBG2 CEP63 MZT2B MAPRE1 MZT2A SFI1 NME7 SDCCAG8 PAFAH1B1 DYNC1I2 DCTN2 SSNA1 DCTN3 MZT1 HAUS8 HAUS7 PRKAR2B CEP70 CEP72 CEP192 PCNT CEP76 CLASP1 CEP78 PLK4 DYNC1H1 ODF2 CEP152 NDE1 PLK1 TUBB4B TUBB4A NUMA1 NEDD1 CENPJ ALMS1 CDK1 CEP41 CEP43 P53-INDEPENDENT G1 S DNA DAMAGE CHECKPOINT%REACTOME DATABASE ID RELEASE 76%69613 p53-Independent G1 S DNA damage checkpoint CHEK1 CDC25A PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 CHEK2 NOTCH2 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME DATABASE ID RELEASE 76%2197563 NOTCH2 intracellular domain regulates transcription GZMB HES1 NOTCH2 EP300 MAML3 MAML2 MAMLD1 FCER2 MAML1 CREB1 RBPJ HES5 SIGNALING BY NOTCH3%REACTOME DATABASE ID RELEASE 76%9012852 Signaling by NOTCH3 PSEN1 CREBBP HES1 PSENEN JAG2 NEURL1 NCSTN HEY1 SNW1 HEY2 EGF MAMLD1 PLXND1 JAG1 UBA52 NEURL1B NOTCH3 EGFR MIB2 MIB1 HEYL UBB STAT1 UBC EP300 RPS27A WWP2 PSEN2 YBX1 MAML2 APH1A MAML1 RBPJ APH1B KAT2B ADAM10 PBX1 KAT2A DLGAP5 TACC3 WWC1 MAML3 DLL1 PTCRA FABP7 NOTCH1 DLL4 HES5 DEPOSITION OF NEW CENPA-CONTAINING NUCLEOSOMES AT THE CENTROMERE%REACTOME DATABASE ID RELEASE 76%606279 Deposition of new CENPA-containing nucleosomes at the centromere NPM1 H2AX H2AB1 H2AC19 H2AC14 H2BC21 CENPA H2BU1 CENPC HJURP OIP5 H2AC8 H2AC6 CENPT H2AC7 CENPU H2BC17 RSF1 H2BC12 H2BC13 CENPH MIS18BP1 CENPI H2BC14 H2AJ CENPW CENPX CENPK H2BC15 CENPL MIS18A CENPM H2BC11 CENPN CENPO CENPP CENPQ CENPS RBBP4 H2BS1 RBBP7 H2AZ1 H2BC9 ITGB3BP H2AZ2 H4C9 H2BC8 H2BC5 H2BC3 SMARCA5 H2BC1 H2AC20 RUVBL1 KNL1 TGFBR2 MSI FRAMESHIFT MUTANTS IN CANCER%REACTOME%R-HSA-3642279.1 TGFBR2 MSI Frameshift Mutants in Cancer TGFB1 TGFBR2 RNA POLYMERASE II TRANSCRIPTION PRE-INITIATION AND PROMOTER OPENING%REACTOME%R-HSA-73779.2 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening GTF2A1 GTF2A2 GTF2B TAF9 TAF1L CCNH GTF2E1 GTF2E2 TAF7L POLR2A POLR2B TAF9B POLR2C TAF15 POLR2D TAF12 POLR2E TAF13 POLR2F TAF10 POLR2G TAF11 POLR2H TAF7 POLR2I TAF4B POLR2J TAF6 POLR2K TAF5 POLR2L TAF4 TAF3 GTF2H1 TAF2 GTF2H2 TAF1 GTF2F1 GTF2H3 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 TBP ERCC2 MNAT1 MATURATION OF REPLICASE PROTEINS%REACTOME DATABASE ID RELEASE 76%9684325 Maturation of replicase proteins 1a rep FOXO-MEDIATED TRANSCRIPTION OF OXIDATIVE STRESS, METABOLIC AND NEURONAL GENES%REACTOME DATABASE ID RELEASE 76%9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO3 ATXN3 HDAC2 HDAC1 NR3C1 SMAD4 SMAD3 GCK PPARGC1A FOXO1 POMC PLXNA4 SREBF1 ABCA6 SOD2 NPY FOXO6 SIN3A IGFBP1 TRIM63 SIRT3 CAT RETN PCK1 FBXO32 G6PC1 SMAD2 AGRP INS FOXO4 RUNX1 REGULATES TRANSCRIPTION OF GENES INVOLVED IN INTERLEUKIN SIGNALING%REACTOME DATABASE ID RELEASE 76%8939247 RUNX1 regulates transcription of genes involved in interleukin signaling ELF1 CBFB IL3 RUNX1 LIFR ERK1 ERK2 PATHWAY%REACTOME%R-HSA-5684996.4 ERK1 ERK2 pathway BRAP CSF2 FN1 BRAF DUSP16 DUSP8 DUSP9 VCL CNKSR2 APBB1IP CNKSR1 MRAS KIT FYN MAPK1 SHOC2 MAPK3 PDGFB PEBP1 ARRB1 PDGFRB IL2 ARRB2 HGF IL3 ERBB2 MARK3 PPP1CB PPP2R1A DUSP10 KSR1 KSR2 SPTB PIK3R2 RET ITGA2B UBA52 MAP2K1 MAP2K2 SHC3 IL6 UBB UBC PTPRA RPS27A ITGB3 JAK2 PDE6D MET CDK1 EREG BTC SRC GOLGA7 SPTBN4 SPTBN5 TGFA FLT3 KRAS TLN1 SPTBN2 ACTN2 RASGRF2 RASGRF1 GRIN2B GRIN1 GRIN2D DLG1 DLG2 DLG3 ARTN LRRC7 DLG4 NEFL GFRA1 GFRA3 GFRA2 GFRA4 RANBP9 NRTN JAK1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSPN BCL2L1 FGB PSMD1 FGA PSMA5 PSMA6 VWF PSMA3 GDNF PSMA4 PSMA1 PSMA2 EPGN FGG PSME3 PSME4 PSME1 PSME2 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 NCAM1 PSMB6 PSMB7 PSMB4 PSMB5 MAPK12 PSMB2 PSMB3 KLB PSMB1 IRS1 PHB PSMF1 PSMB8 IRS2 PSMB9 PIK3CB FGF1 SEM1 PSMC5 FGF2 PSMC6 FGF3 PSMC3 FGF4 PSMC4 FGF6 RASGRP1 PSMC1 FGF7 PSMC2 FGF9 RAP1B RAP1A FGF20 RAF1 FGF23 FGF22 FLT3LG FRS2 SPTA1 FGF16 FGF19 FGF18 FGFR4 FGF10 PPP2R1B PPP2R5E PRKG2 FRS3 PPP2R5B RCE1 PPP2R5A PPP2R5D PPP2R5C ARL2 PPP2CA PPP2CB IL5RA CSF2RB IL2RG CSF2RA IL5 MAP3K11 IL2RB IL3RA PTPN11 USP17L2 PIK3R1 IQGAP1 CALM1 SPTAN1 SPTBN1 EGF TYK2 YWHAB DUSP4 DUSP6 DUSP7 PTK2 CAMK2B CSK CAMK2D CAMK2A CAMK2G PPP1CC RASGRP4 PRKCQ SHC1 PIK3CA SOS1 RBX1 PPP5C SHC2 RALGDS AREG JAK3 IL6R NRG1 NRG2 NRG3 NRG4 CUL3 IL2RA RASGRP3 HBEGF EGFR ICMT ABHD17C ZDHHC9 ABHD17B SPRED3 ABHD17A FNTB SPRED2 SPRED1 SYNGAP1 HRAS PDGFRA RASA3 RASA4 RASA1 RASA2 RASAL1 WDR83 RASAL2 PAQR3 RASAL3 RGL3 NRAS LAMTOR2 RGL1 DAB2IP RGL2 NF1 PEA15 KBTBD7 LAMTOR3 DUSP5 DUSP2 DUSP1 FNTA ARAF IL17RD RAPGEF2 RASGEF1A ANGPT1 TEK PTPN7 LYPLA1 PTPN3 CELLULAR RESPONSE TO STARVATION%REACTOME DATABASE ID RELEASE 76%9711097 Cellular response to starvation ATP6V1G3 ATP6V0E2 ATP6V1H ATP6V1A ATP6V1D ATP6V1F CEBPB CEBPG EIF2S2 EIF2S1 EIF2S3 DDIT3 TRIB3 RPL4 RPL5 RPL30 ATF3 RPL3 ATF4 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A ATP6V1B2 RPL8 ATP6V1B1 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA EIF2AK4 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 RPS15A ATF2 IMPACT RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 TCIRG1 RPL35A RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 GCN1 RPS24 RPS23 SESN2 SEC13 ATP6V1E1 ATP6V1E2 ATP6V1G1 ATP6V1G2 ATP6V0E1 FLCN SESN1 C12orf66 SZT2 MIOS ITFG2 ATP6V0D1 KPTN ATP6V0D2 DEPDC5 SEH1L NPRL2 NPRL3 WDR24 SH3BP4 FNIP1 FNIP2 WDR59 CASTOR1 ASNS CASTOR2 BMT2 ATP6V1C1 ATP6V1C2 RPTOR MLST8 SLC38A9 MTOR RRAGA RRAGC RHEB RRAGB RRAGD LAMTOR2 LAMTOR1 LAMTOR4 ATP6V0B LAMTOR3 LAMTOR5 ATP6V0C TOLERANCE OF REACTIVE OXYGEN PRODUCED BY MACROPHAGES%REACTOME DATABASE ID RELEASE 76%1222387 Tolerance of reactive oxygen produced by macrophages secA2 sodC sodB ahpC katG secY secF secE secA1 secG secD JOSEPHIN DOMAIN DUBS%REACTOME DATABASE ID RELEASE 76%5689877 Josephin domain DUBs ATXN3 UBB PRKN RAD23A UBA52 UBC RAD23B ATXN3L RPS27A VCP JOSD2 JOSD1 INOSITOL PHOSPHATE METABOLISM%REACTOME%R-HSA-1483249.3 Inositol phosphate metabolism IP6K1 PLCD3 IP6K2 PLCB3 PLCD4 PLCB1 PLCD1 PLCB2 PTEN ISYNA1 NUDT11 NUDT10 INPP1 PPIP5K1 PLCG1 PPIP5K2 IP6K3 NUDT3 IMPA1 NUDT4 IMPA2 MIOX INPP5A PLCB4 INPP4A INPP4B SYNJ1 PLD4 INPP5D INPPL1 OCRL ITPK1 MTMR9 MTMR7 INPP5B PLCZ1 MINPP1 PLCE1 CALM1 ITPKB ITPKC INPP5J ITPKA IPPK PLCG2 PLCH1 IPMK PLCH2 RHOH GTPASE CYCLE%REACTOME%R-HSA-9013407.1 RHOH GTPase cycle VANGL1 RALGAPA1 VCP FAM91A1 ROCK1 PAK4 ROCK2 LCK CAV1 TFRC ARHGDIG STOM NSFL1C ARHGDIA JUP SLC4A7 OSBPL11 MTR NIPSNAP2 DBN1 DBT CSK ARHGDIB PAK2 RAB7A UACA PAK5 LAMTOR1 WDR11 TMEM59 ZAP70 TUBA1B PAK1 VAMP3 PAK6 SLC1A5 RHOH DRUG RESISTANCE OF KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9669937 Drug resistance of KIT mutants KIT DEFECTIVE ABCA3 CAUSES SMDP3%REACTOME%R-HSA-5683678.2 Defective ABCA3 causes SMDP3 ABCA3 PRC2 METHYLATES HISTONES AND DNA%REACTOME%R-HSA-212300.1 PRC2 methylates histones and DNA H3C15 RBBP4 H2BS1 RBBP7 DNMT1 H2AZ1 H2BC9 PHF19 H2AZ2 EZH2 H4C9 PHF1 H2BC8 H2BC5 DNMT3B H2BC3 JARID2 EED H2BC1 H2AX AEBP2 MTF2 H2AB1 H2AC20 H2AC19 SUZ12 H2AC14 H2BC21 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 H2BC14 H2AJ H2BC15 H2BC11 SLC-MEDIATED TRANSMEMBRANE TRANSPORT%REACTOME%R-HSA-425407.3 SLC-mediated transmembrane transport SLC20A1 SLC3A2 SLC43A1 RUNX1 MFSD4B SLC31A1 SLC30A7 SLC30A6 SLC30A8 SLC30A3 SLC36A4 SLC30A2 SLC30A5 SLC30A1 SLC24A2 SLC24A1 SLC24A4 SLC24A3 SLC8B1 SLC41A2 SLC1A2 SLC41A1 SLC1A4 SLC1A6 SLC1A7 SLC2A3 SLC2A6 SLC2A7 SLC1A5 SLC50A1 SLC4A7 SLC4A8 SLC4A9 BSG SLC6A20 SLC4A1 SLC4A4 SLC12A6 SLC39A4 SLC34A3 SLC34A2 SLC6A19 SLC6A18 SLC6A14 SLC11A2 SLC5A7 SLC1A1 SLC1A3 SLC5A1 SLC5A2 FGF21 CP SLC2A9 SLC6A5 SLC26A4 SLC11A1 ALB SLC26A3 SLC2A1 SLC40A1 SLC22A4 SLC2A2 SLC22A3 SLC6A2 RSC1A1 SLC6A3 SLC22A15 SLC22A5 SLC22A12 SLC22A16 HEPH SLC22A18 SLC22A2 SLC22A1 SLC36A2 SLC2A10 SLC7A7 SLC7A9 SLC20A2 SLC8A1 SLC8A2 SLC3A1 PDZD11 SLC12A3 SLC16A1 SLC4A2 SLC12A1 SLC4A3 SLC4A5 RHAG SLC5A9 SLC2A4 SLC2A8 ARL2 SLC30A10 SLC5A3 SRI SLC5A4 SLC16A10 SLC6A6 SLC6A9 SLC8A3 SLC35B3 SLC35B2 SLC6A1 LCN9 SLC27A1 SLC35B4 EMB SLC35D1 SLC18A1 SLC35D2 CALM1 SLC18A2 SLC2A14 SLCO1B1 LCN15 SLC2A11 SLC2A13 SLCO2B1 LCN12 SLC2A12 SLCO1B3 APOD SLC39A10 SLC16A2 SLC39A14 SLC35A2 SLC7A6 SLC35A1 SLC7A8 SLC35A3 SLC35C1 SLC7A1 SLC33A1 SLC7A3 SLCO1C1 ARL2BP RHBG SLCO4A1 SLCO4C1 SLCO2A1 SLCO1A2 LCN1 SLC27A6 SLC6A12 SLC29A4 SLC6A11 SLC25A5 SLC29A1 SLC9A2 SLC28A2 SLC9A3 SLC9A4 SLC25A4 SLC28A1 SLC9A5 SLC29A3 SLC9A6 SLC9A7 SLC25A6 SLC9A8 SLC27A4 SLC29A2 SLC39A6 SLC9A9 SLC28A3 SLC16A7 SLC9A1 SLC39A5 SLC16A8 SLC39A8 SLC26A11 SLC39A7 SLC39A2 SLC16A3 SLC39A1 SLC39A3 SLC15A1 SLC5A5 SLC38A1 SLC15A2 RHCG SLC26A1 SLC15A3 SLC38A3 SLC15A4 SLC38A2 SLC26A2 SLC38A5 SLC38A4 SLC14A1 SLC14A2 SLC6A7 SLC4A10 SLC26A7 SLC26A9 SLC44A1 SLC26A6 SLC13A1 SLC36A1 SLC13A2 SLC13A3 AVP SLC13A4 SLC7A5 SLC47A2 SLC47A1 SLC5A11 SLC5A12 SLC5A10 SLC25A26 SLC25A29 SLC13A5 SLC12A2 SLC12A4 SLC12A5 CTNS SLC5A6 AHCYL2 SLC12A7 SLC6A15 SLC6A13 SLC22A6 SLC45A3 SLC10A6 SLC22A8 SLC22A7 SLC44A5 SLC44A3 SLC44A4 SLC44A2 SLC7A11 SLC34A1 SLC7A10 SLC22A11 SLC32A1 SLC25A10 SLC5A8 SLC25A18 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A1 SLC25A22 SLC43A2 BETA OXIDATION OF BUTANOYL-COA TO ACETYL-COA%REACTOME DATABASE ID RELEASE 76%77352 Beta oxidation of butanoyl-CoA to acetyl-CoA HADH ECHS1 ACADS ACSM3 ACSM6 RESPIRATORY ELECTRON TRANSPORT%REACTOME%R-HSA-611105.3 Respiratory electron transport NDUFB4 NDUFB3 ETFDH NDUFB2 NDUFB1 UQCR11 UQCR10 NDUFA9 NDUFA8 NDUFA7 TIMMDC1 NDUFA6 NUBPL NDUFA3 NDUFA2 NDUFA1 NDUFS3 CYC1 NDUFA5 NDUFB8 NDUFC2 MT-CO1 COX7A2L SCO1 SCO2 MT-CO2 MT-CO3 SURF1 COX7B COX7C COX8A COX5B COX5A COX6C LRPPRC TACO1 COX6A1 COX6B1 COX19 COX16 COX18 ETFB COX11 COX14 NDUFAB1 CYCS COX20 MT-ND6 COX4I1 MT-ND4 NDUFA13 MT-ND5 NDUFA11 NDUFA12 NDUFA10 MT-ND2 MT-ND3 MT-ND1 SDHC SDHD SDHA SDHB UQCRC1 UQCRC2 TMEM126B NDUFA4 NDUFB10 UQCRB NDUFB11 UQCRH NDUFV3 NDUFV2 NDUFV1 TRAP1 COA1 NDUFAF6 NDUFAF7 UQCRQ NDUFAF4 NDUFAF5 NDUFAF2 NDUFAF3 ECSIT NDUFAF1 MT-CYB ETFA TMEM186 UQCRFS1 ACAD9 NDUFC1 COQ10B COQ10A NDUFS8 NDUFS7 NDUFS6 NDUFS5 NDUFS4 NDUFS2 NDUFS1 NDUFB9 NDUFB7 NDUFB6 NDUFB5 MITOTIC SPINDLE CHECKPOINT%REACTOME DATABASE ID RELEASE 76%69618 Mitotic Spindle Checkpoint PPP2R1B PPP2R5E NUP43 RANBP2 PPP2R5B CDCA8 PPP2R5A SKA1 PPP2R5D SKA2 PPP2R5C NUP37 NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU PPP2R1A CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN DYNLL2 CENPO CENPP CENPQ CENPS DYNLL1 CKAP5 CLIP1 KIF18A MAD1L1 MAPRE1 NDC80 PAFAH1B1 DYNC1I2 SPDL1 XPO1 CENPF RANGAP1 NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 RCC2 ZWINT AHCTF1 ZW10 NDEL1 KIF2A KIF2C MIS12 KIF2B RPS27 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L CENPE ZWILCH KNTC1 SGO1 SGO2 PMF1 BUB1B ANAPC15 BUB3 ANAPC16 SEC13 MAD2L1 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 BUB1 NUP107 CDC16 CDC27 ANAPC4 ANAPC5 ANAPC1 DYNC1I1 BIRC5 ITGB3BP NUP160 NUP85 CLASP2 NUP133 PYRIMIDINE SALVAGE%REACTOME DATABASE ID RELEASE 76%73614 Pyrimidine salvage TYMP TK1 UPP2 UCKL1 UCK2 UPP1 UCK1 TK2 PUDP CDA DCK TRANSCRIPTIONAL REGULATION BY E2F6%REACTOME%R-HSA-8953750.2 Transcriptional Regulation by E2F6 YAF2 RBBP4 CBX5 PHC1 APAF1 BMI1 E2F6 RING1 RBBP7 MGA CDC7 EZH2 MAX PHC3 CBX3 BRCA1 UXT EED EHMT2 EPC1 SUZ12 TFDP1 TFDP2 E2F1 RNF2 RRM2 RBBP8 L3MBTL2 RAD51 EHMT1 CHEK1 PCGF6 PCGF2 RYBP EUKARYOTIC TRANSLATION INITIATION%REACTOME DATABASE ID RELEASE 76%72613 Eukaryotic Translation Initiation EIF2S2 EIF2S1 EIF2S3 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 RPS4X RPS15 RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RPL21 RPS8 RPS5 RPL23 RPL22 RPS6 RPL13A RPSA PABPC1 RPS3A RPL9P9 RPS27A RPL37A RPL24 RPL27 RPL26 RPL29 RPL28 RPS4Y2 RPL10 RPL12 RPL11 RPL36A RPS27L RPS4Y1 EIF4G1 RPS15A RPL14 RPS3 RPL13 RPS2 RPL15 RPL18 RPL17 RPL19 RPL39L RPL41 RPL35A EIF5 RPL23A RPL3L RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 EIF2B5 EIF2B4 EIF2B3 EIF2B2 EIF2B1 EIF5B EIF4H EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B EIF4A2 EIF4A1 EIF4EBP1 EIF4E EIF4B SODIUM-COUPLED SULPHATE, DI- AND TRI-CARBOXYLATE TRANSPORTERS%REACTOME DATABASE ID RELEASE 76%433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters SLC13A5 SLC13A1 SLC13A2 SLC13A3 SLC13A4 HDL ASSEMBLY%REACTOME DATABASE ID RELEASE 76%8963896 HDL assembly APOA1 ZDHHC8 PRKACA A2M ABCA1 PRKACG PRKACB FBXL7 DOWN-REGULATES AURKA DURING MITOTIC ENTRY AND IN EARLY MITOSIS%REACTOME DATABASE ID RELEASE 76%8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RBX1 SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 FBXL7 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 FBXL18 PSMA7 PSMB10 CUL1 PSMA8 AURKA PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 S37 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 76%5358749 S37 mutants of beta-catenin aren't phosphorylated PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 SIGNALING BY PHOSPHORYLATED JUXTAMEMBRANE, EXTRACELLULAR AND KINASE DOMAIN KIT MUTANTS%REACTOME DATABASE ID RELEASE 76%9670439 Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5A STAT5B STAT1 HRAS PIK3CA SOS1 NRAS LCK PIK3R1 JAK2 PIK3R3 KIT FYN STAT3 PIK3R2 LYN YES1 DISORDERS OF NERVOUS SYSTEM DEVELOPMENT%REACTOME%R-HSA-9697154.1 Disorders of Nervous System Development NCOR1 HDAC3 CAMK4 HDAC1 PRKACA GPS2 CALM1 TBL1XR1 NCOR2 SIN3A TBL1X S33 MUTANTS OF BETA-CATENIN AREN'T PHOSPHORYLATED%REACTOME DATABASE ID RELEASE 76%5358747 S33 mutants of beta-catenin aren't phosphorylated PPP2CA PPP2CB APC PPP2R1B PPP2R5E CTNNB1 PPP2R5B PPP2R5A GSK3B PPP2R5D PPP2R1A PPP2R5C AXIN1 CSNK1A1 AMER1 ACYL CHAIN REMODELLING OF PG%REACTOME%R-HSA-1482925.1 Acyl chain remodelling of PG CRLS1 PLA2G2F PLA2G4F PLA2G2D PLA2G12A PLA2G4D PLA2G2E PLA2G4B LPGAT1 PLA2G4A LPCAT4 PLA2G10 PLA2G2A PLA2R1 PLA2G3 LPCAT1 PLA2G1B PLA2G5 SIGNALING DOWNSTREAM OF RAS MUTANTS%REACTOME%R-HSA-9649948.1 Signaling downstream of RAS mutants BRAP FN1 BRAF FGB FGA VWF KRAS FGG TLN1 VCL ITGA2B CNKSR2 APBB1IP CNKSR1 MAP2K1 MAP2K2 YWHAB MAPK1 MAPK3 PEBP1 ARRB1 ARRB2 CAMK2B PHB CSK CAMK2D HRAS CAMK2A MARK3 MAP3K11 CAMK2G NRAS ITGB3 RAP1B RAP1A RAF1 KSR1 ARAF IQGAP1 JAK2 KSR2 CALM1 SRC TRAF3-DEPENDENT IRF ACTIVATION PATHWAY%REACTOME DATABASE ID RELEASE 76%918233 TRAF3-dependent IRF activation pathway CREBBP IFIH1 RNF135 MAVS DDX58 EP300 TRIM25 IRF7 IFNB1 TBK1 SIKE1 IKBKE IRF3 TRAF3 SYNTHESIS OF 15-EICOSATETRAENOIC ACID DERIVATIVES%REACTOME%R-HSA-2142770.1 Synthesis of 15-eicosatetraenoic acid derivatives GPX2 GPX1 PTGS2 GPX4 ALOX15 ALOX15B TRAFFICKING OF GLUR2-CONTAINING AMPA RECEPTORS%REACTOME%R-HSA-416993.1 Trafficking of GluR2-containing AMPA receptors GRIA3 GRIA4 PRKCA PRKCB PRKCG NSF PICK1 AP2A1 GRIP1 GRIA1 GRIP2 GRIA2 TSPAN7 REGULATION OF SIGNALING BY CBL%REACTOME DATABASE ID RELEASE 76%912631 Regulation of signaling by CBL CRKL PIK3CB CRK PIK3CA PIK3CD SYK PIK3R1 PIK3R3 RAPGEF1 FYN HCK BLNK VAV1 CBL PIK3R2 LYN YES1 NFG AND PRONGF BINDS TO P75NTR%REACTOME DATABASE ID RELEASE 76%205017 NFG and proNGF binds to p75NTR NGF SORCS3 NGFR GAMMA-CARBOXYLATION OF PROTEIN PRECURSORS%REACTOME DATABASE ID RELEASE 76%159740 Gamma-carboxylation of protein precursors F7 PROC F2 F9 F10 GGCX BGLAP PROS1 PROZ GAS6 CONSTITUTIVE SIGNALING BY OVEREXPRESSED ERBB2%REACTOME DATABASE ID RELEASE 76%9634285 Constitutive Signaling by Overexpressed ERBB2 HSP90AA1 CDC37 HRAS ERBB2 ERBIN SHC1 PTPN12 SOS1 NRAS RESOLUTION OF SISTER CHROMATID COHESION%REACTOME DATABASE ID RELEASE 76%2500257 Resolution of Sister Chromatid Cohesion PPP2R1B PPP2R5E NUP43 RANBP2 PPP2R5B CDCA8 PPP2R5A SKA1 PPP2R5D SKA2 PPP2R5C NUP37 NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU PPP2R1A CENPH CENPI TAOK1 CENPK CENPL CENPM CENPN DYNLL2 CENPO CENPP CENPQ CENPS SMC3 DYNLL1 CKAP5 CLIP1 RAD21 KIF18A MAD1L1 MAPRE1 NDC80 STAG1 STAG2 PAFAH1B1 SMC1A DYNC1I2 SPDL1 XPO1 CENPF RANGAP1 CCNB2 CCNB1 NSL1 CDC20 AURKB PPP1CC CLASP1 KNL1 DYNC1H1 NDE1 DSN1 PLK1 RCC2 ZWINT AHCTF1 CDK1 ZW10 NDEL1 KIF2A KIF2C MIS12 KIF2B RPS27 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L CENPE ZWILCH KNTC1 SGO1 SGO2 PMF1 BUB1B BUB3 SEC13 MAD2L1 BUB1 NUP107 DYNC1I1 BIRC5 ITGB3BP NUP160 NUP85 CLASP2 CDCA5 NUP133 PDS5B PDS5A WAPL TRANSCRIPTIONAL REGULATION BY MECP2%REACTOME%R-HSA-8986944.2 Transcriptional Regulation by MECP2 HDAC3 TRPC3 PPARG BDNF AGO3 GAD1 PVALB GAD2 AGO4 MEF2C GRIN2B AGO1 AGO2 RBFOX1 GRIA2 GPRIN1 GRIN2A MOBP LBR SGK1 OPRM1 SLC2A3 PRKACA CALM1 DLL1 DGCR8 HDAC2 HDAC1 PTEN FKBP5 GAMT OPRK1 PTPN1 PTPN4 SST CAMK2B CAMK2D FOXG1 CAMK2A SOX2 GPS2 HTT AURKB CAMK2G TBL1XR1 HIPK2 SIN3A NCOR2 TNRC6C TBL1X MOV10 CREB1 NCOR1 CAMK4 TNRC6A TNRC6B CRH MET IRAK1 FRUCTOSE METABOLISM%REACTOME%R-HSA-5652084.6 Fructose metabolism SORD KHK GLYCTK AKR1B1 TKFC ALDH1A1 ALDOB TOXICITY OF BOTULINUM TOXIN TYPE E (BOTE)%REACTOME DATABASE ID RELEASE 76%5250992 Toxicity of botulinum toxin type E (botE) SNAP25 botE ntnha SV2B SV2A RNA POLYMERASE III TRANSCRIPTION INITIATION FROM TYPE 1 PROMOTER%REACTOME%R-HSA-76061.2 RNA Polymerase III Transcription Initiation From Type 1 Promoter CRCP POLR3GL POLR3A POLR2E POLR3B POLR2F POLR3C POLR3D POLR2H POLR3E POLR3F POLR3G POLR2K POLR3H POLR2L POLR3K TBP GTF3A GTF3C1 GTF3C2 GTF3C3 GTF3C4 GTF3C5 GTF3C6 BRF1 BDP1 POLR1C POLR1D ARACHIDONIC ACID METABOLISM%REACTOME%R-HSA-2142753.5 Arachidonic acid metabolism PLA2G4A GPX2 CYP4B1 GPX1 GPX4 ALOX15 ALOX12 ALOX12B ALOXE3 CYP4F2 CYP4F3 CYP4F8 CYP1A1 ALOX5 PTGS2 EPHX2 PTGIS PTGS1 AKR1C3 CYP2C9 CYP8B1 CYP2C8 CYP1A2 PTGES2 GGT1 FAAH ABCC1 DPEP2 DPEP1 PTGES3 DPEP3 HPGDS PTGES HPGD LTA4H CYP4F22 CYP2C19 GGT5 CYP2J2 ALOX15B PRXL2B CYP4F11 MAPKAPK2 TBXAS1 CYP4A22 CBR1 FAAH2 PTGR1 PTGDS PTGR2 PON3 CYP4A11 PON2 CYP1B1 PON1 LTC4S AWAT1 CYP2U1 ALOX5AP DEFECTIVE POMGNT1 CAUSES MDDGA3, MDDGB3 AND MDDGC3%REACTOME DATABASE ID RELEASE 76%5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 DAG1 POMGNT1 SYNTHESIS AND PROCESSING OF ENV AND VPU%REACTOME DATABASE ID RELEASE 76%171286 Synthesis and processing of ENV and VPU env FURIN vpu IRS-RELATED EVENTS TRIGGERED BY IGF1R%REACTOME%R-HSA-2428928.1 IRS-related events triggered by IGF1R GAB1 PIK3CA FLT3 SOS1 AKT2 IRS4 KLB IRS1 PDE3B HRAS PIK3R4 IRS2 PIK3CB FGF1 FGF2 PDPK1 FGF3 FGF4 FGF6 NRAS FGF7 PTPN11 FGF9 FGF20 THEM4 FGF23 PIK3R1 FGF22 IGF1 FLT3LG FRS2 GAB2 FGF16 TRIB3 FGF19 FGF18 TLR9 IGF2 PIK3C3 IGF1R FGFR4 PIK3R2 FGF10 NEGATIVE REGULATION OF NOTCH4 SIGNALING%REACTOME%R-HSA-9604323.1 Negative regulation of NOTCH4 signaling RBX1 TACC3 SKP1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME1 PSME2 UBA52 PSMD10 PSMD12 PSMD11 PSMD14 PSMD13 NOTCH4 PSMA7 PSMB10 CUL1 AKT1 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 YWHAZ PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 PAUSING AND RECOVERY OF HIV ELONGATION%REACTOME DATABASE ID RELEASE 76%167290 Pausing and recovery of HIV elongation CTDP1 ELL CCNT1 SUPT4H1 ELOA3DP ELOA NELFB ELOB ELOC NELFCD NELFA ELOA3BP NELFE SUPT16H ELOA3P ELOA2 SSRP1 CDK9 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J POLR2K POLR2L SUPT5H GTF2F1 GTF2F2 CCNK TCEA1 SYNTHESIS OF PC%REACTOME%R-HSA-1483191.4 Synthesis of PC CHKA STARD10 LPIN2 CHAT PEMT LPIN3 SLC44A1 PHOSPHO1 CEPT1 PCYT1B PCYT1A CSNK2A1 CSNK2A2 CSNK2B ABHD3 SLC44A5 PCTP SLC44A3 SLC44A4 SLC44A2 CHPT1 ACHE MFSD2A BCHE STARD7 LPCAT1 CHKB LPIN1 MITOCHONDRIAL TRANSLATION%REACTOME DATABASE ID RELEASE 76%5368287 Mitochondrial translation GFM2 MRRF MTFMT MRPS17 MRPS15 GFM1 MTRF1L MRPS16 MTIF2 MRPS14 MTIF3 MRPS11 MRPS12 MRPL38 MRPL39 MRPS10 MRPL36 MRPL37 MRPL34 MRPL35 MRPL32 MRPL33 MRPL4 MRPL41 MRPL42 MRPL3 MRPL2 MRPL1 MRPL40 MRPL9 CHCHD1 MRPS28 TSFM MRPS26 MRPS27 MRPS24 MRPS25 MRPS22 MRPS23 MRPS18B MRPL49 MRPS18A MRPS2 MRPS21 MRPL47 MRPL48 MRPL45 MRPS7 MRPL46 MRPS6 MRPL43 MRPS5 MRPL44 TUFM MRPS18C MRPL52 MRPL53 OXA1L MRPS9 MRPL50 MRPL51 AURKAIP1 DAP3 MRPS35 MRPS36 MRPL18 MRPS33 MRPS34 MRPL19 MRPL16 MRPS31 MRPL17 MRPL58 MRPL14 MRPL15 MRPS30 MRPL12 MRPL57 MRPL13 MRPL10 MRPL54 MRPL55 MRPL11 MRPL20 PTCD3 GADD45GIP1 MRPL27 MRPL28 ERAL1 MRPL23 MRPL24 MRPL21 MRPL22 MRPL30 LEISHMANIA PARASITE GROWTH AND SURVIVAL%REACTOME%R-HSA-9664433.1 Leishmania parasite growth and survival V1-20 GPR15 IGKV2D-40 IGHV3-11 IGHV3-13 GPR27 GPR25 GPR20 RLN2 IGHV1-46 RLN3 ADM PTH1R IGHV IL10 LPG1G2 V5-4 V5-1 SYK GPR32 PTH2R FYN V5-6 HCK IGLV3-19 RAMP2 RAMP3 GPR45 PTH GNAI3 PRKX GNAI1 GNAI2 IGLV3-25 INSL3 IGLV3-27 IGKC IGLV3-21 TSHB GPR150 PTGIR V4-6 V4-2 V4-1 AVPR2 IGKV1-5 SCTR GCG GHRH ADM2 RAMP1 IGLV PRKACA IGHG3 IGHG4 ADORA2A IGHG1 ADORA2B IGHG2 GGT1 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 DPEP2 DPEP1 IAPP DPEP3 GNAZ CALCA CALCB CALCRL IGHV4-59 GPR83 GPR84 IGLV2-11 CALCR IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 TSHR IGKV3-15 IGKV3-11 POMC V2-8 GGT5 CD163 IGLV7-43 IGKV1D-16 IGKV1D-12 IL6 IGLV1-51 IGLV2-23 IGKV3-20 GLP1R PRKAR2B IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RHBDF2 GLP2R IGKV3D-20 GIP CRH ADAM17 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 PTH2 PTHLH IGKV1-39 IGKV1-33 FCGR1A IGHV3-53 IGLC7 IGKV5-2 IGLC6 FCGR2A VIP CD3G FURIN FGR HTR4 RXFP1 ITPR1 RXFP2 GNG10 ITPR2 ITPR3 HTR6 HTR7 GNG12 GNG11 GNG13 GNB2 PTGDR GNB1 TAAR8 GNB4 TAAR9 TAAR6 GNB3 TAAR5 MYH9 TAAR2 GNB5 TAAR1 GNGT1 GNGT2 LHB CALM1 ADCYAP1 ADCYAP1R1 MC2R GNG3 GNG2 CGA GNG5 GNG4 GNG7 GNG8 MC1R LYN YES1 MC4R CREB1 MAPK14 GPR39 FSHB PLK2 GPBAR1 MC3R ADRB3 PLCG1 PRKACG FSHR PRKACB AVP PTGER4 NPSR1 ADCY9 PRKAR1B PRKAR1A PRKAR2A PTGER2 GNAS NPS ADCY4 ADCY3 ADCY2 ADCY1 GPHA2 ADCY8 ADCY7 ADCY6 ADCY5 P2RY11 MC5R GPHB5 CYSLTR1 CYSLTR2 VIPR1 VIPR2 LHCGR AHCYL1 SCT IGHV3-23 IGLV2-8 GPR176 IGKV1-16 GNAT3 IGKV1-17 IGKV1-12 ADRB1 IGHV3-7 ADRB2 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 TAAR3P V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 HRH2 V1-11 IGKV2D-30 GIPR V1-16 DRD1 V1-13 IGHV1-69 CRHR1 CRHR2 DRD5 GHRHR PLCG2 TANDEM OF PORE DOMAIN IN A WEAK INWARDLY RECTIFYING K+ CHANNELS (TWIK)%REACTOME DATABASE ID RELEASE 76%1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) KCNK1 KCNK6 KCNK7 INHIBITION OF VOLTAGE GATED CA2+ CHANNELS VIA GBETA GAMMA SUBUNITS%REACTOME%R-HSA-997272.1 Inhibition of voltage gated Ca2+ channels via Gbeta gamma subunits KCNJ2 KCNJ3 KCNJ4 KCNJ5 GNG3 KCNJ6 KCNJ10 GNG2 KCNJ9 GNG5 KCNJ12 GNG4 GNG7 KCNJ15 GNG8 KCNJ16 GABBR2 GABBR1 GNG10 GNG12 GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 GNGT1 GNGT2 PYROPTOSIS%REACTOME DATABASE ID RELEASE 76%5620971 Pyroptosis GSDMD IRF1 IRF2 TP53 CASP1 ELANE GSDME CHMP2B CHMP2A HMGB1 IL18 BAX IL1A IL1B CASP5 CASP3 CASP4 BAK1 GZMB CHMP4C CHMP4B CHMP3 CHMP4A CHMP6 CHMP7 TP63 CYCS DEFECTIVE LMBRD1 CAUSES METHYLMALONIC ACIDURIA AND HOMOCYSTINURIA TYPE CBLF%REACTOME DATABASE ID RELEASE 76%3359458 Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF LMBRD1 VIRION ASSEMBLY AND RELEASE%REACTOME DATABASE ID RELEASE 76%9694322 Virion Assembly and Release 7a N 3a M E S INHIBITION OF INTERFERON SYNTHESIS%REACTOME%R-HSA-168305.4 Inhibition of Interferon Synthesis NS NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION%REACTOME%R-HSA-2122947.3 NOTCH1 Intracellular Domain Regulates Transcription HDAC3 CREBBP HDAC2 HDAC1 HDAC6 HES1 HEY1 SNW1 HEY2 HIF1A MAMLD1 RBX1 UBA52 TLE4 TLE2 CUL1 TLE1 HEYL UBB UBC NBEA EP300 RPS27A CDK8 TBL1XR1 NCOR2 MAML2 MAML1 TBL1X RBPJ NCOR1 HDAC10 MYC HDAC11 KAT2B CCNC KAT2A HDAC5 HDAC8 HDAC9 MAML3 SKP1 HDAC4 NOTCH1 HDAC7 HES5 TRANSPORT OF HA TRIMER, NA TETRAMER AND M2 TETRAMER FROM THE ENDOPLASMIC RETICULUM TO THE GOLGI APPARATUS%REACTOME DATABASE ID RELEASE 76%168874 Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi Apparatus NA HA M ROBO RECEPTORS BIND AKAP5%REACTOME DATABASE ID RELEASE 76%9010642 ROBO receptors bind AKAP5 ROBO2 PRKCA PRKACA PRKAR2A AKAP5 PRKACG PPP3CB PRKACB ASSEMBLY OF THE PRE-REPLICATIVE COMPLEX%REACTOME%R-HSA-68867.5 Assembly of the pre-replicative complex MCM7 MCM8 MCM3 MCM4 MCM5 MCM6 MCM2 ORC5 ORC4 ORC6 ORC1 ORC3 ORC2 CDT1 CDC6 GMNN PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 PSMA4 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 E2F1 PSMC6 E2F2 PSMC3 E2F3 PSMC4 PSMC1 PSMC2 TP53 REGULATES TRANSCRIPTION OF DNA REPAIR GENES%REACTOME%R-HSA-6796648.3 TP53 Regulates Transcription of DNA Repair Genes CTDP1 ELL CCNT1 CDK12 TP53 SUPT4H1 CDK13 ELOA3DP ELOA NELFB ELOB ELOC NELFCD ATM NELFA ELOA3BP NELFE SUPT16H FOS ELOA3P DDB2 ELOA2 SSRP1 CDK9 CCNH ATR POLR2A PMS2 POLR2B POLR2C POLR2D POLR2E MLH1 BRCA1 POLR2F POLR2G POLR2H CCNT2 POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 SUPT5H GTF2F1 MSH2 GTF2H3 FANCD2 GTF2H4 GTF2F2 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 FANCI CHEK1 FANCC JUN RAD51D MDC1 CCNK ATF2 TCEA1 RESISTANCE OF ERBB2 KD MUTANTS TO TESEVATINIB%REACTOME DATABASE ID RELEASE 76%9665245 Resistance of ERBB2 KD mutants to tesevatinib HSP90AA1 CDC37 ERBB2 ERBIN SIGNALING BY FGFR1 IN DISEASE%REACTOME%R-HSA-5655302.2 Signaling by FGFR1 in disease CUX1 GAB1 ZMYM2 PIK3CA LRRFIP1 PLCG1 SOS1 STAT3 ERLIN2 STAT5A STAT5B STAT1 HRAS CPSF6 FGF1 FGF2 FGF4 FGF6 NRAS FGFR1 BAG4 FGF9 FGF20 MYO18A FGF23 PIK3R1 BCR FRS2 FGFR1OP2 GAB2 TRIM24 CEP43 DEFECTIVE ABCD1 CAUSES ALD%REACTOME DATABASE ID RELEASE 76%5684045 Defective ABCD1 causes ALD ABCD1 GAP JUNCTION DEGRADATION%REACTOME%R-HSA-190873.2 Gap junction degradation CLTC DNM2 CLTB DAB2 MYO6 GJA1 CLTCL1 AP2M1 CLTA DNM1 ACTIVATION OF HOX GENES DURING DIFFERENTIATION%REACTOME DATABASE ID RELEASE 76%5619507 Activation of HOX genes during differentiation HDAC3 CREBBP RXRA RARA YY1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F KMT2D POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 KMT2C POLR2K H2AC19 POLR2L H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 PKNOX1 H2BC14 H2AJ PBX1 CNOT6 H2BC15 CTCF HOXA2 H2BC11 CNOT9 PIAS2 H3C15 RBBP4 WDR5 PAXIP1 H2BS1 RBBP7 EGR2 NCOA3 H2AZ1 H2BC9 H2AZ2 EZH2 AJUBA H4C9 H2BC8 H2BC5 HOXA3 H2BC3 HOXA1 RBBP5 HOXA4 EED H2BC1 RARG ASH2L HOXB4 HOXB3 HOXB2 H2AC20 HOXB1 HOXD1 RARB SUZ12 HOXC4 JUN HOXD4 HOXD3 NCOA6 ZNF335 MAFB PAGR1 NCOR1 KDM6A PAX6 PCGF2 MEIS1 DEFECTIVE ABCB6 CAUSES MCOPCB7%REACTOME DATABASE ID RELEASE 76%5683371 Defective ABCB6 causes MCOPCB7 ABCB6 REPLICATION OF THE SARS-COV-2 GENOME%REACTOME DATABASE ID RELEASE 76%9694686 Replication of the SARS-CoV-2 genome GSK3B RB1 ZCRB1 DDX5 VHL N GSK3A rep FORMATION OF THE TERNARY COMPLEX, AND SUBSEQUENTLY, THE 43S COMPLEX%REACTOME%R-HSA-72695.2 Formation of the ternary complex, and subsequently, the 43S complex RPS26 RPS25 RPS28 RPS27 RPS29 RPS20 FAU RPS21 RPS24 RPS23 EIF2S2 EIF2S1 EIF2S3 EIF1AX EIF3M EIF3K EIF3L EIF3I EIF3J EIF3G EIF3H EIF3E EIF3F EIF3C EIF3D EIF3A EIF3B RPS4X RPS15 RPS14 RPS17 RPS16 RPS19 RPS18 RPS11 RPS10 RPS13 RPS12 RPS9 RPS7 RPS8 RPS5 RPS6 RPSA RPS3A RPS27A RPS4Y2 RPS27L RPS4Y1 RPS15A RPS3 RPS2 RHOBTB GTPASE CYCLE%REACTOME DATABASE ID RELEASE 76%9706574 RHOBTB GTPase Cycle MSI2 TXNL1 ACTN1 SPEN RNF20 CCT2 CPSF7 ROCK1 PHIP ROCK2 CUL3 RHOBTB2 GPS1 RHOBTB1 SRRM1 COPS4 TRA2B COPS2 STK38 MYO6 PDE5A RBBP6 VIM ACTG1 DDX39B HNRNPC CCT7 RBMX TWF1 DBN1 HSP90AA1 TMOD3 CCT6A CDC37 HSP90AB1 FUSION AND UNCOATING OF THE INFLUENZA VIRION%REACTOME DATABASE ID RELEASE 76%168270 Fusion and Uncoating of the Influenza Virion PA PB2 NP NA NS HA M PB1 PLATELET ADHESION TO EXPOSED COLLAGEN%REACTOME%R-HSA-75892.3 Platelet Adhesion to exposed collagen ITGA10 VWF GP1BB ITGB1 GP1BA GP5 ITGA2 ITGA1 GP6 GP9 FYN LYN FCER1G MISCELLANEOUS SUBSTRATES%REACTOME%R-HSA-211958.2 Miscellaneous substrates CYP4B1 CYP4F11 CYP2D6 CYP4A11 CYP4F22 CYP3A43 CYP4F2 CYP4F3 CYP2W1 CYP4A22 CYP2U1 CYP2S1 FGFR2B LIGAND BINDING AND ACTIVATION%REACTOME DATABASE ID RELEASE 76%190377 FGFR2b ligand binding and activation FGFBP3 FGF22 FGF1 FGF2 FGF3 FGF7 FGF10 FGFBP1 FGFBP2 CRMPS IN SEMA3A SIGNALING%REACTOME%R-HSA-399956.1 CRMPs in Sema3A signaling NRP1 PLXNA4 PLXNA3 FES GSK3B CDK5 FYN DPYSL4 DPYSL5 CRMP1 SEMA3A DPYSL2 DPYSL3 CDK5R1 PLXNA2 PLXNA1 DEGRADATION OF CYSTEINE AND HOMOCYSTEINE%REACTOME DATABASE ID RELEASE 76%1614558 Degradation of cysteine and homocysteine CSAD ADO SQOR MPST TSTD1 GOT2 TST SUOX TXN2 SLC25A10 ETHE1 CTH CDO1 GADL1 TRNA MODIFICATION IN THE NUCLEUS AND CYTOSOL%REACTOME%R-HSA-6782315.5 tRNA modification in the nucleus and cytosol FTSJ1 THADA OSGEP TRMT9B TRMT12 TRMT13 TRMT11 WDR4 NSUN2 NSUN6 QTRT1 DUS2 QTRT2 CTU2 CTU1 URM1 TYW1 LCMT2 TRDMT1 TRMT10A ADAT1 TPRKB TRMT1 ADAT3 ADAT2 TRMT5 TRMT6 TRMT61A TP53RK TRIT1 THG1L ALKBH8 TRMT112 TRMT44 PUS3 TYW5 EPRS1 METTL1 TYW3 CDKAL1 PUS7 PARASITE INFECTION%REACTOME%R-HSA-9664407.1 Parasite infection V1-20 IGKV2D-40 IGHV3-11 IGHV3-13 IGHV1-46 IGHV LPG1G2 CYFIP1 V5-4 NCKAP1 V5-1 ARPC4 SYK FGR ARPC5 FYN VAV3 V5-6 HCK MAPK1 BRK1 VAV1 IGLV3-19 ARPC2 ELMO2 ARPC3 MAPK3 WAS IGLV3-25 IGLV3-27 IGKC IGLV3-21 V4-6 V4-2 V4-1 MYH9 IGKV1-5 ACTR2 MYO9B WASL VAV2 IGLV IGHG3 CDC42 IGHG4 IGHG1 IGHG2 V3-4 V3-3 V3-2 IGKV1D-39 IGKV1D-33 NCK1 ABL1 IGHV4-59 NCKAP1L WASF1 IGLV2-11 NCKIPSD WASF2 IGLV1-40 IGLV1-47 IGLV6-57 IGLV2-14 IGLV1-44 MYO1C IGKV3-15 BAIAP2 IGKV3-11 V2-8 ABI2 IGLV7-43 ARPC1B ABI1 ACTG1 IGKV1D-16 IGKV1D-12 LYN YES1 IGLV1-51 IGLV2-23 IGKV3-20 PTK2 IGHV4-34 IGHV1-2 IGHV4-39 FCGR3A IGKV2-29 IGKV2-28 IGLC3 IGLC1 IGLC2 V1-9 V1-7 V1-5 V1-3 RAC1 IGKV3D-20 MYH2 IGKV2-30 IGHV2-70 IGHV2-5 IGHV3-48 IGLV3-1 IGKV1-39 IGKV1-33 WASF3 IGHV3-53 IGLC7 MYO10 IGKV5-2 DOCK1 IGLC6 MYO5A BTK ACTB CD3G ARPC1A ELMO1 CRK CYFIP2 WIPF1 WIPF2 IGHV3-23 WIPF3 IGLV2-8 IGKV1-16 IGKV1-17 IGKV1-12 IGHV3-7 IGHV3-9 IGHV3-30 V2-17 IGHV3-33 V2-15 V2-19 IGKV2D-28 IGKV4-1 IGHV7-81 V1-11 IGKV2D-30 V1-16 V1-13 IGHV1-69 DEFECTIVE CYP24A1 CAUSES HCAI%REACTOME DATABASE ID RELEASE 76%5579010 Defective CYP24A1 causes HCAI CYP24A1 MATURATION OF PROTEIN M%REACTOME DATABASE ID RELEASE 76%9683612 Maturation of protein M M ISG15 ANTIVIRAL MECHANISM%REACTOME DATABASE ID RELEASE 76%1169408 ISG15 antiviral mechanism KPNA7 KPNA4 NUP42 KPNA5 USP41 NUP43 KPNA2 EIF4E2 RAE1 KPNA3 RANBP2 PLCG1 EIF2AK2 NUP35 EIF4A3 NUP37 MX2 MX1 MAPK3 KPNA1 STAT1 UBA7 NS KPNB1 UBE2L6 NEDD4 HERC5 SEC13 UBE2E1 ISG15 IRF3 NUP107 PIN1 NUP188 JAK1 EIF4A2 NUP210 EIF4A1 NUP93 POM121 IFIT1 NUP205 UBA52 AAAS NUP160 POM121C NUP85 TPR NUP88 NUP155 EIF4E NUP214 NUP153 USP18 UBB UBC DDX58 TRIM25 RPS27A ARIH1 NUP62 gag FLNB NDC1 NUP133 EIF4G3 EIF4G1 EIF4G2 EIF4E3 NUP50 NUP54 UBE2N PPM1B MITOTIC METAPHASE AND ANAPHASE%REACTOME DATABASE ID RELEASE 76%2555396 Mitotic Metaphase and Anaphase LBR EMD KPNB1 TUBA1A PPP2R1A LEMD3 PPP2R2A VPS4A DYNLL1 CKAP5 TUBA4A KIF18A MAPRE1 UBA52 IST1 PAFAH1B1 DYNC1I2 CENPF CCNB2 CCNB1 UBB UBC RPS27A CLASP1 DYNC1H1 NDE1 PLK1 TUBB4B TUBB4A CDK1 ZW10 KIF2A UBE2I KIF2C KIF2B RPS27 SUMO1 CENPE ANAPC15 ANAPC16 SEC13 ANAPC7 UBE2C UBE2E1 UBE2D1 ANAPC10 ANAPC11 CDC23 UBE2S CDC26 NUP107 CDC16 CDC27 NUP188 ANAPC4 ANAPC5 ANAPC1 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 PSMD5 PSMD2 DYNC1I1 BANF1 PSMD3 PSMD1 PSMA5 NUP93 PSMA6 PSMA3 POM121 PSMA4 NUP205 PSMA1 PSMA2 PSME3 PSME4 PSME1 PSME2 PSMD10 ITGB3BP PSMB11 PSMD12 PSMD11 NUP160 PSMD14 NUP85 PSMD13 PSMA7 PSMB10 PSMA8 NUP155 PSMB6 PSMB7 PSMB4 CLASP2 PSMB5 PSMB2 PSMB3 PSMB1 PSMF1 PSMB8 PSMB9 SEM1 PSMC5 PSMC6 PSMC3 CHMP4C PSMC4 CHMP4B PSMC1 PSMC2 CHMP4A NUP62 NDC1 CDCA5 NUP133 PDS5B PDS5A WAPL NUP54 PPP2R1B PPP2R5E TUBB6 TUBB3 TUBB1 NUP43 VRK1 RANBP2 RAN PPP2R5B CDCA8 PPP2R5A NUP35 SKA1 PPP2R5D SKA2 CHMP2B PPP2R5C NUP37 ANKLE2 CHMP2A TUBA4B NUF2 NUDC PPP2CA PPP2CB INCENP CENPA CENPC CENPT CENPU CHMP3 TUBA8 CENPH CHMP6 TUBA1C CENPI CHMP7 TUBA1B TAOK1 CENPK CENPL CENPM TUBB2B TUBB2A CENPN DYNLL2 CENPO CENPP CENPQ CENPS TUBAL3 SMC3 TUBA3E TUBB8 SPAST TUBB8B LEMD2 CC2D1B TUBA3D TUBA3C CLIP1 RAD21 MAD1L1 STAG1 NDC80 STAG2 SMC1A SPDL1 XPO1 RANGAP1 TNPO1 NSL1 CDC20 LMNB1 ESPL1 PTTG1 AURKB PPP1CC KNL1 DSN1 RCC2 ZWINT AHCTF1 NDEL1 MIS12 DYNC1LI1 DYNC1LI2 B9D2 SPC24 SPC25 ERCC6L ZWILCH KNTC1 SGO1 SGO2 PMF1 RCC1 BUB1B BUB3 MAD2L1 BUB1 SIRT2 FBXO5 BIRC5 DEFECTIVE GALK1 CAN CAUSE GALACTOSEMIA II (GALCT2)%REACTOME%R-HSA-5609976.2 Defective GALK1 can cause Galactosemia II (GALCT2) GALK1 GAB1 SIGNALOSOME%REACTOME%R-HSA-180292.3 GAB1 signalosome CSK GAB1 TGFA PIK3CA EGF PXN PTPN11 EPGN PAG1 PIK3R1 HBEGF AREG EGFR EREG BTC SRC ATTACHMENT OF GPI ANCHOR TO UPAR%REACTOME%R-HSA-162791.2 Attachment of GPI anchor to uPAR PIGK PIGS PLAUR PIGU PIGT GPAA1 PGAP1 NUCLEOTIDE EXCISION REPAIR%REACTOME%R-HSA-5696398.2 Nucleotide Excision Repair YY1 RFC5 RFC3 RFC4 RFC2 CETN2 RPA1 RPA2 RPA3 UBA52 UBB RUVBL1 UBC POLK NFRKB POLE RPS27A RNF111 LIG1 PARP1 RFC1 PARP2 ACTR5 USP45 ACTL6A LIG3 RAD23A ACTR8 CHD1L RAD23B UBE2V2 INO80C INO80B INO80E INO80D XPC POLD3 PIAS3 TFPT UBE2I POLD4 POLD1 POLD2 ELL MCRS1 XRCC1 INO80 POLE4 ERCC4 ERCC1 PIAS1 POLE2 POLE3 ERCC5 SUMO1 SUMO3 SUMO2 DDB2 RBX1 PCNA CCNH POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR2L GTF2H1 GTF2H2 ACTB GTF2H3 EP300 GTF2H4 GTF2H5 CDK7 ERCC3 ERCC2 MNAT1 GPS1 COPS4 COPS2 ERCC6 ISY1 PRPF19 HMGN1 USP7 AQR DDB1 PPIE ZNF830 XPA COPS7B COPS7A CUL4A COPS3 XAB2 COPS6 COPS5 UVSSA ERCC8 TCEA1 COPS8 CUL4B UBE2N CHYLOMICRON ASSEMBLY%REACTOME DATABASE ID RELEASE 76%8963888 Chylomicron assembly MTTP APOA1 APOA4 APOC2 P4HB APOE APOB APOC3 SAR1B APOA2 DEFECTIVE B4GALT7 CAUSES EDS, PROGEROID TYPE%REACTOME DATABASE ID RELEASE 76%3560783 Defective B4GALT7 causes EDS, progeroid type GPC5 GPC4 CSPG5 GPC6 CSPG4 DCN SDC1 AGRN B4GALT7 HSPG2 SDC4 BCAN SDC2 SDC3 NCAN BGN GPC1 VCAN GPC3 GPC2 FUSION OF THE INFLUENZA VIRION TO THE HOST CELL ENDOSOME%REACTOME%R-HSA-168288.3 Fusion of the Influenza Virion to the Host Cell Endosome PA PB2 NP NA NS HA M PB1 EVASION OF OXIDATIVE STRESS INDUCED SENESCENCE DUE TO DEFECTIVE P16INK4A BINDING TO CDK4 AND CDK6%REACTOME%R-HSA-9632700.2 Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 CDK6 CDKN2A CDK4 REGULATION OF RUNX2 EXPRESSION AND ACTIVITY%REACTOME DATABASE ID RELEASE 76%8939902 Regulation of RUNX2 expression and activity CBFB NR3C1 ESR1 RBX1 PPARGC1A MSX2 SKP2 DLX5 DLX6 STAT1 BMP2 PPARGC1B STUB1 ESRRA SKP1 PSMD8 PSMD9 PSMD6 PSMD7 NKX3-2 PSMD4 PSMD5 PSMD2 PSMD3 PSMD1 PSMA5 PSMA6 PSMA3 WWP1 PSMA4 PSMA1 PSMA2 PSME3 GSK3B PSME4 PSME1 PSME2 UBA52 PSMD10 PSMB11 PSMD12 PSMD11 PSMD14 PSMD13 PSMA7 PSMB10 CUL1 PSMA8 PSMB6 PSMB7 PSMB4 PSMB5 PSMB2 UBB PSMB3 PSMB1 PSMF1 UBC PSMB8 PSMB9 RPS27A SEM1 PSMC5 PSMC6 PSMC3 PSMC4 PSMC1 PSMC2 TWIST1 SMURF1 HIVEP3 N-GLYCAN ANTENNAE ELONGATION%REACTOME%R-HSA-975577.1 N-Glycan antennae elongation MGAT5 ST3GAL4 ST6GAL1 B4GALT2 MGAT4C B4GALT3 MGAT4A MGAT4B ST8SIA6 B4GALT6 B4GALT4 B4GALT1 ST8SIA2 B4GALT5 ST8SIA3 CD209 (DC-SIGN) SIGNALING%REACTOME DATABASE ID RELEASE 76%5621575 CD209 (DC-SIGN) signaling CREBBP HRAS PAK2 ICAM2 ICAM3 RELA EP300 NRAS PRKACG RELB PRKACB RAF1 FYN PRKACA PAK3 PAK1 CD209 NFKB1 RPS6KA5 LYN MAJOR PATHWAY OF RRNA PROCESSING IN THE NUCLEOLUS AND CYTOSOL%REACTOME DATABASE ID RELEASE 76%6791226 Major pathway of rRNA processing in the nucleolus and cytosol RPP21 RCL1 RPP25 TBL3 MPHOSPH10 NOL11 RPP14 RPP40 XRN2 RPL4 RPL5 RPL30 RPL3 RPL32 RPL31 RPL34 RPLP1 RPL10L RPLP0 RPL10A RPL8 RPL6 RPL7 CSNK1D RPS4X RPS15 CSNK1E RPL7A RPS14 RPS17 RPS16 RPL18A RPS19 RPS18 RPL36AL RPL36 RPL35 RPLP2 RPL38 UBA52 RPL37 RPS11 NOP56 RPL39 RPS10 RPS13 RPS12 RPS9 RPS7 RRP1 RPL21 SNU13 LAS1L RPS8 DIS3 NOP58 RPS5 RPL23 RPL22 RPS6 RIOK2 RPL13A RPSA RIOK1 TEX10 RPS3A RPL9P9 GNL3 RPS27A RPL37A NIP7 RPL24 EXOSC10 RPL27 RIOK3 EXOSC7 WDR18 RPL26 EXOSC6 WDR12 RPL29 EXOSC5 BYSL RPL28 EXOSC4 TSR1 FTSJ3 RPS4Y2 EXOSC9 EBNA1BP2 RPL10 EXOSC8 NCL RPL12 EXOSC3 ISG20L2 RPL11 EXOSC2 NOB1 RPL36A EXOSC1 C1D RPS27L RPS4Y1 RPS15A LTV1 RPL14 ERI1 RPS3 NOL12 RPL13 NOL9 RPS2 PES1 RPL15 RPL18 BOP1 RPL17 MPHOSPH6 RBM28 RPL19 RPL39L SENP3 RPL41 RPL35A RPL23A RPL3L MTREX RPS26 RPS25 RPS28 RPS27 RPS29 RPL27A RPL22L1 RPS20 FAU RPS21 RPL26L1 RPS24 RPS23 PELP1 DDX21 DDX49 DDX47 WDR3 FCF1 PWP2 WDR46 WDR43 RRP9 FBL BUD23 UTP14A UTP14C UTP15 WDR36 UTP11 IMP3 WDR75 IMP4 DDX52 UTP18 DIEXF HEATR1 NOC4L NOL6 RRP7A EMG1 PDCD11 BMS1 DHX37 RRP36 UTP20 RPP30 DCAF13 UTP6 NOP14 UTP4 PNO1 KRR1 RPP38 UTP3 P75NTR REGULATES AXONOGENESIS%REACTOME DATABASE ID RELEASE 76%193697 p75NTR regulates axonogenesis OMG NGF MAG MCF2 ARHGDIA RHOA LINGO1 RTN4 NGFR APC TRUNCATION MUTANTS ARE NOT K63 POLYUBIQUITINATED%REACTOME DATABASE ID RELEASE 76%5467333 APC truncation mutants are not K63 polyubiquitinated APC RHO GTPASES ACTIVATE KTN1%REACTOME%R-HSA-5625970.1 RHO GTPases activate KTN1 KLC2 RAC1 KIF5B CDC42 KIF5A KTN1 RHOG KLC1 RHOA KLC4 KLC3 ABACAVIR TRANSPORT AND METABOLISM%REACTOME%R-HSA-2161522.2 Abacavir transport and metabolism SLC22A2 SLC22A1 ABCB1 GUK1 PCK1 SLC22A3 ADH1A ADAL ABCG2 NT5C2 SIGNALING BY WNT%REACTOME%R-HSA-195721.5 Signaling by WNT CREBBP PRKG1 PLCB3 PLCB1 PRKCB PLCB2 NLK FZD8 PPP3R1 FZD7 WNT11 PDE6B PDE6A FZD3 FZD5 PDE6G FZD6 KREMEN1 NFATC1 KREMEN2 GNAO1 AMER1 RNF43 ARRB2 PORCN RAC3 WNT3A PPP2R1A BTRC LRP5 SKP1 LRP6 PRKCG WNT5B ROR1 ROR2 CSNK1E PRICKLE1 WNT1 WNT4 FZD1 RYK CAV1 DVL1 UBA52 DVL3 CUL1 ASH2L RSPO3 UBB RUVBL1 UBC RPS27A CHD8 CBY1 SOX3 SOX17 MYC SOX6 RAC1 SOX7 SOX4 BCL9L CTNNBIP1 SOX13 PYGO1 PYGO2 RUNX3 BCL9 TCF7 LEF1 TCF7L2 TCF7L1 SMURF2 CTNNB1 PFN1 FRAT1 FRAT2 TLE4 TLE3 TLE2 TLE1 H2AX TLE5 H2AB1 H2AC19 H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 RNF146 H2AC8 H2AC6 H2AC7 TERT CLTA AP2A1 H2BC17 H2BC12 H2BC13 AP2A2 H2BC14 H2AJ H2BC15 AP2M1 H2BC11 PSMD8 PSMD9 PSMD6 PSMD7 PSMD4 HDAC1 PSMD5 PSMD2 H3C15 PSMD3 PSMD1 PSMA5 PSMA6 SRY PSMA3 H2BS1 PSMA4 PSMA1 PSMA2 PSME3 PSME4 H2AZ1 PSME1 H2BC9 PSME2 PSMD10 H2AZ2 H4C9 PSMB11 H2BC8 PSMD12 AP2S1 H2BC5 PSMD11 XIAP PSMD14 H2BC3 PSMD13 RBBP5 PSMA7 H2BC1 PSMB10 PSMA8 ZNRF3 RSPO2 PSMB6 RSPO1 PSMB7 H2AC20 PSMB4 LGR6 ZRANB1 PSMB5 LGR5 PSMB2 AP2B1 LGR4 RSPO4 PSMB3 APC SFRP1 PSMB1 SFRP2 PSMF1 HECW1 WNT10B CCDC88C PSMB8 SOX2 WIF1 PSMB9 WNT5A KLHL12 SEM1 PSMC5 SOST PSMC6 DACT1 SOX9 PSMC3 CXXC4 PSMC4 PSMC1 PSMC2 KAT5 CDC73 TRRAP PPP2R1B LEO1 PPP2R5E PRKG2 DAAM1 SNX3 PPP2R5B PPP2R5A PPP2R5D CSNK2A1 PPP2R5C CSNK2A2 CSNK2B ITPR1 GNG10 ITPR2 ITPR3 PPP2CA GNG12 PPP2CB GNG11 GNG13 GNB2 GNB1 GNB4 GNB3 GNB5 CLTC GNGT1 H3-4 GNGT2 USP8 CALM1 MEN1 GNG3 USP34 GNG2 GNG5 GNG4 GNG7 GSK3B GNG8 AXIN1 AXIN2 WLS VPS29 XPO1 PIP5K1B AKT1 VPS35 TMED5 VPS26A PRKCA YWHAZ SCRIB CAMK2A VANGL2 TNRC6C MOV10 TNRC6A TNRC6B CTBP2 CTBP1 RBX1 AGO3 AGO4 WNT10A AGO1 AGO2 WNT9B WNT9A KMT2D WNT8A WNT8B FZD4 WNT7B WNT7A WNT6 WNT2 WNT3 WNT2B WNT16 CLTB CSNK1A1 CSNK1G2 CUL3 AKT2 RAC2 TNKS2 TNKS SMURF1 DKK1 DKK2 RHOA DKK4 PPP3CA DVL2 PPP3CB PARD6A GNAT2 SMARCA4 MAP3K7 REACTIONS SPECIFIC TO THE COMPLEX N-GLYCAN SYNTHESIS PATHWAY%REACTOME DATABASE ID RELEASE 76%975578 Reactions specific to the complex N-glycan synthesis pathway MAN2A1 MGAT2 CHST10 CHST8 LHB MAN2A2 FUCA1 CGA FUT3 FUT8 ACTIVATION OF ANTERIOR HOX GENES IN HINDBRAIN DEVELOPMENT DURING EARLY EMBRYOGENESIS%REACTOME%R-HSA-5617472.2 Activation of anterior HOX genes in hindbrain development during early embryogenesis HDAC3 CREBBP RXRA RARA YY1 POLR2A POLR2B POLR2C POLR2D POLR2E POLR2F KMT2D POLR2G POLR2H H2AX POLR2I POLR2J H2AB1 KMT2C POLR2K H2AC19 POLR2L H2AC14 H2BC21 EP300 H2BU1 H3-3B H3C8 H2AC8 H2AC6 H2AC7 H2BC17 H2BC12 H2BC13 PKNOX1 H2BC14 H2AJ PBX1 CNOT6 H2BC15 CTCF HOXA2 H2BC11 CNOT9 PIAS2 H3C15 RBBP4 WDR5 PAXIP1 H2BS1 RBBP7 EGR2 NCOA3 H2AZ1 H2BC9 H2AZ2 EZH2 AJUBA H4C9 H2BC8 H2BC5 HOXA3 H2BC3 HOXA1 RBBP5 HOXA4 EED H2BC1 RARG ASH2L HOXB4 HOXB3 HOXB2 H2AC20 HOXB1 HOXD1 RARB SUZ12 HOXC4 JUN HOXD4 HOXD3 NCOA6 ZNF335 MAFB PAGR1 NCOR1 KDM6A PAX6 PCGF2 MEIS1 DEFECTIVE GFPT1 CAUSES CMSTA1%REACTOME%R-HSA-4085023.1 Defective GFPT1 causes CMSTA1 GFPT1 WIKIPATHWAYS-20210510-GMT-RATTUS_NORVEGICUS.GMT wikipathways-20210510-gmt-Rattus_norvegicus.gmt FILE File WIKIPATHWAYS-20210510-GMT-POPULUS_TRICHOCARPA.GMT wikipathways-20210510-gmt-Populus_trichocarpa.gmt WIKIPATHWAYS-20210510-GMT-HOMO_SAPIENS.GMT wikipathways-20210510-gmt-Homo_sapiens.gmt WIKIPATHWAYS-20210510-GMT-CAENORHABDITIS_ELEGANS.GMT wikipathways-20210510-gmt-Caenorhabditis_elegans.gmt FILE File FILE File WIKIPATHWAYS-20210510-GMT-CANIS_FAMILIARIS.GMT wikipathways-20210510-gmt-Canis_familiaris.gmt WIKIPATHWAYS-20210510-GMT-DROSOPHILA_MELANOGASTER.GMT wikipathways-20210510-gmt-Drosophila_melanogaster.gmt WIKIPATHWAYS-20210510-GMT-ORYZA_SATIVA.GMT wikipathways-20210510-gmt-Oryza_sativa.gmt
857 857 105,515 105,515 FILENAME Filename MAY 10 2021 5:06 AM May 10 2021 5:06 AM FILE File 61,461 61,461 MAY 10 2021 5:05 AM May 10 2021 5:05 AM 19,385 19,385 FILE File 15,265 15,265 161 161 WIKIPATHWAYS DATA WikiPathways Data MAY 10 2021 5:02 AM May 10 2021 5:02 AM 17,476 17,476 24,663 24,663
353 353
SIZE (BYTES) Size (bytes) 4,633 4,633 WIKIPATHWAYS-20210510-GMT-SACCHAROMYCES_CEREVISIAE.GMT wikipathways-20210510-gmt-Saccharomyces_cerevisiae.gmt 6,991 6,991 MAY 10 2021 5:05 AM May 10 2021 5:05 AM WIKIPATHWAYS-20210510-GMT-EQUUS_CABALLUS.GMT wikipathways-20210510-gmt-Equus_caballus.gmt FILE File MAY 10 2021 5:03 AM May 10 2021 5:03 AM WIKIPATHWAYS-20210510-GMT-ARABIDOPSIS_THALIANA.GMT wikipathways-20210510-gmt-Arabidopsis_thaliana.gmt 40,488 40,488 MAY 10 2021 5:03 AM May 10 2021 5:03 AM

WIKIPATHWAYS DATA DOWNLOADS

WikiPathways Data Downloads

84,706 84,706 MAY 10 2021 5:00 AM May 10 2021 5:00 AM MAY 10 2021 5:02 AM May 10 2021 5:02 AM FILE File --> --> FILE File WIKIPATHWAYS-20210510-GMT-DANIO_RERIO.GMT wikipathways-20210510-gmt-Danio_rerio.gmt 235,738 235,738 WIKIPATHWAYS-20210510-GMT-MUS_MUSCULUS.GMT wikipathways-20210510-gmt-Mus_musculus.gmt 7,051 7,051 MAY 10 2021 5:04 AM May 10 2021 5:04 AM FILE File FILE File 1,626 1,626 MAY 10 2021 5:01 AM May 10 2021 5:01 AM WIKIPATHWAYS-20210510-GMT-PAN_TROGLODYTES.GMT wikipathways-20210510-gmt-Pan_troglodytes.gmt WIKIPATHWAYS-20210510-GMT-SUS_SCROFA.GMT wikipathways-20210510-gmt-Sus_scrofa.gmt 17,112 17,112 WIKIPATHWAYS-20210510-GMT-BOS_TAURUS.GMT wikipathways-20210510-gmt-Bos_taurus.gmt MAY 10 2021 5:03 AM May 10 2021 5:03 AM MAY 10 2021 5:06 AM May 10 2021 5:06 AM